{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:58:30Z","timestamp":1790377110206,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Nantong Science and Technology Plan Project","award":["MSZ2025175"],"award-info":[{"award-number":["MSZ2025175"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"DOI":"10.1007\/s12013-026-02183-0","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:38:13Z","timestamp":1790329093000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["EphA2 Silencing Attenuates IL-1\u03b2-Induced Chondrocyte Ferroptosis and Extracellular Matrix Degradation In Vitro"],"prefix":"10.1007","author":[{"given":"Yan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"2183_CR1","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","volume":"392","author":"GBD 2017 Disease and Injury Incidence and Prevalence Collaborators","year":"2018","unstructured":"GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. (2018). Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017. The Lancet, 392, 1789\u20131858.","journal-title":"The Lancet"},{"key":"2183_CR2","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","volume":"393","author":"DJ Hunter","year":"2019","unstructured":"Hunter, D. J., & Bierma-Zeinstra, S. (2019). Osteoarthritis. The Lancet, 393, 1745\u20131759.","journal-title":"The Lancet"},{"key":"2183_CR3","doi-asserted-by":"publisher","first-page":"e40871","DOI":"10.1016\/j.heliyon.2024.e40871","volume":"10","author":"MN Ferrao Blanco","year":"2024","unstructured":"Ferrao Blanco, M. N., Lesage, R., Kops, N., Fahy, N., Bekedam, F. T., et al. (2024). A multi-model approach identifies ALW-II-41-27 as a promising therapy for osteoarthritis-associated inflammation and endochondral ossification. Heliyon, 10, e40871.","journal-title":"Heliyon"},{"key":"2183_CR4","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., et al. (2012). Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell, 149, 1060\u20131072.","journal-title":"Cell"},{"key":"2183_CR5","doi-asserted-by":"publisher","first-page":"1790918","DOI":"10.3389\/fimmu.2026.1790918","volume":"17","author":"L Zhou","year":"2026","unstructured":"Zhou, L., Ju, S., Wang, K., Fu, Z., Wu, R., et al. (2026). Research progress on the mechanism of chondrocyte ferroptosis in osteoarthritis. Frontiers in Immunology, 17, 1790918.","journal-title":"Frontiers in Immunology"},{"key":"2183_CR6","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","volume":"185","author":"BR Stockwell","year":"2022","unstructured":"Stockwell, B. R. (2022). Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. Cell, 185, 2401\u20132421.","journal-title":"Cell"},{"key":"2183_CR7","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jot.2020.09.006","volume":"27","author":"X Yao","year":"2020","unstructured":"Yao, X., Sun, K., Yu, S., Luo, J., Guo, J., et al. (2020). Chondrocyte ferroptosis contribute to the progression of osteoarthritis. Journal of Orthopaedic Translation, 27, 33\u201343.","journal-title":"Journal of Orthopaedic Translation"},{"key":"2183_CR8","doi-asserted-by":"publisher","first-page":"e13779","DOI":"10.1111\/cpr.13779","volume":"58","author":"Y Zhang","year":"2025","unstructured":"Zhang, Y., Li, J., Liu, J., Gao, Y., Li, K., et al. (2025). Ferroptosis in osteoarthritis: Towards novel therapeutic strategy. Cell Proliferation, 58, e13779.","journal-title":"Cell Proliferation"},{"key":"2183_CR9","doi-asserted-by":"publisher","first-page":"103248","DOI":"10.1016\/j.tice.2025.103248","volume":"99","author":"C Fan","year":"2026","unstructured":"Fan, C., Ma, J., Fan, F., Yi, R., & Wang, W. (2026). RBM15-mediated m6A modification upregulates KDM2A to promote ferroptosis in osteoarthritis cells. Tissue and Cell, 99, 103248.","journal-title":"Tissue and Cell"},{"key":"2183_CR10","doi-asserted-by":"publisher","first-page":"157789","DOI":"10.1016\/j.phymed.2026.157789","volume":"151","author":"Y Zhou","year":"2026","unstructured":"Zhou, Y., Xue, Y., Jiang, M., Weiyang, W., Chen, W., et al. (2026). Didymin halts knee osteoarthritis progression by targeting the GSK3B\/5-LOX\/11-HETE pathway to suppress chondrocyte ferroptosis. Phytomedicine, 151, 157789.","journal-title":"Phytomedicine"},{"key":"2183_CR11","doi-asserted-by":"publisher","first-page":"e71106","DOI":"10.1111\/jcmm.71106","volume":"30","author":"Q Yi","year":"2026","unstructured":"Yi, Q., Li, J., Luo, G., Li, J., Yang, D. et al. (2026). Targeting ferroptosis with natural products for the treatment of skeletal system disease: An updated review. Journal of Cellular and Molecular Medicine, 30, e71106.","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"2183_CR12","doi-asserted-by":"publisher","first-page":"1639458","DOI":"10.3389\/fmed.2025.1639458","volume":"12","author":"M Xiao","year":"2025","unstructured":"Xiao, M., Ji, L., Feng, S., & Qian, W. (2025). Serum levels of EphA2 are elevated in knee osteoarthritis and associated with disease severity. Frontiers in Medicine, 12, 1639458.","journal-title":"Frontiers in Medicine"},{"key":"2183_CR13","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1172\/JCI72522","volume":"124","author":"KR Amato","year":"2014","unstructured":"Amato, K. R., Wang, S., Hastings, A. K., Youngblood, V. M., Santapuram, P. R., et al. (2014). Genetic and pharmacologic inhibition of EPHA2 promotes apoptosis in NSCLC. Journal of Clinical Investigation, 124, 2037\u20132049.","journal-title":"Journal of Clinical Investigation"},{"key":"2183_CR14","doi-asserted-by":"publisher","first-page":"103161","DOI":"10.1016\/j.tice.2025.103161","volume":"98","author":"K Zhang","year":"2026","unstructured":"Zhang, K., Zeng, L., Min, H., Jiang, X., Li, Y., & Hu, K. (2026). Crosstalk between programmed cell death in chondrocytes-a molecular mechanism of osteoarthritis. Tissue and Cell, 98, 103161.","journal-title":"Tissue and Cell"},{"key":"2183_CR15","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","volume":"7","author":"M Kapoor","year":"2011","unstructured":"Kapoor, M., Martel-Pelletier, J., Lajeunesse, D., Pelletier, J. P., & Fahmi, H. (2011). Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nature Reviews Rheumatology, 7, 33\u201342.","journal-title":"Nature Reviews Rheumatology"},{"key":"2183_CR16","doi-asserted-by":"publisher","first-page":"26035","DOI":"10.3390\/ijms161125943","volume":"16","author":"HS Hwang","year":"2015","unstructured":"Hwang, H. S., & Kim, H. A. (2015). Chondrocyte apoptosis in the pathogenesis of osteoarthritis. International Journal of Molecular Sciences, 16, 26035\u201326054.","journal-title":"International Journal of Molecular Sciences"},{"key":"2183_CR17","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1097\/BOR.0b013e328349c2b1","volume":"23","author":"MB Goldring","year":"2011","unstructured":"Goldring, M. B., & Otero, M. (2011). Inflammation in osteoarthritis. Current Opinion in Rheumatology, 23, 471\u2013478.","journal-title":"Current Opinion in Rheumatology"},{"key":"2183_CR18","doi-asserted-by":"publisher","first-page":"7859","DOI":"10.1038\/sj.onc.1208937","volume":"24","author":"WB Fang","year":"2005","unstructured":"Fang, W. B., Brantley-Sieders, D. M., Parker, M. A., Reith, A. D., & Chen, J. (2005). A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis. Oncogene, 24, 7859\u20137868.","journal-title":"Oncogene"},{"key":"2183_CR19","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/nrc2806","volume":"10","author":"EB Pasquale","year":"2010","unstructured":"Pasquale, E. B. (2010). Eph receptors and ephrins in cancer: Bidirectional signalling and beyond. Nature Reviews Cancer, 10, 165\u2013180.","journal-title":"Nature Reviews Cancer"},{"key":"2183_CR20","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ccr.2009.04.009","volume":"16","author":"H Miao","year":"2009","unstructured":"Miao, H., Li, D. Q., Mukherjee, A., Guo, H., Petty, A., et al. (2009). EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. Cancer Cell, 16, 9\u201320.","journal-title":"Cancer Cell"},{"key":"2183_CR21","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1158\/1541-7786.MCR-10-0298","volume":"9","author":"ML Taddei","year":"2011","unstructured":"Taddei, M. L., Parri, M., Angelucci, A., Bianchini, F., Marconi, C., et al. (2011). EphA2 induces metastatic growth regulating amoeboid motility and clonogenic potential in prostate carcinoma cells. Molecular Cancer Research, 9, 149\u2013160.","journal-title":"Molecular Cancer Research"},{"key":"2183_CR22","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1038\/nature03369","volume":"434","author":"SS Glasson","year":"2005","unstructured":"Glasson, S. S., Askew, R., Sheppard, B., Carito, B., Blanchet, T., et al. (2005). Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature, 434, 644\u2013648.","journal-title":"Nature"},{"key":"2183_CR23","doi-asserted-by":"publisher","first-page":"3723","DOI":"10.1002\/art.25002","volume":"60","author":"CB Little","year":"2009","unstructured":"Little, C. B., Barai, A., Burkhardt, D., Smith, S. M., Fosang, A. J., et al. (2009). Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis & Rheumatism, 60, 3723\u20133733.","journal-title":"Arthritis & Rheumatism"},{"key":"2183_CR24","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.joca.2006.04.008","volume":"14","author":"JA Roman-Blas","year":"2006","unstructured":"Roman-Blas, J. A., & Jimenez, S. A. (2006). NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis. Osteoarthritis and Cartilage, 14, 839\u2013848.","journal-title":"Osteoarthritis and Cartilage"},{"key":"2183_CR25","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1016\/j.biocel.2013.08.018","volume":"45","author":"S Rigoglou","year":"2013","unstructured":"Rigoglou, S., & Papavassiliou, A. G. (2013). The NF-\u03baB signalling pathway in osteoarthritis. International Journal of Biochemistry & Cell Biology, 45, 2580\u20132584.","journal-title":"International Journal of Biochemistry & Cell Biology"},{"key":"2183_CR26","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1177\/19476035221142011","volume":"14","author":"W Xu","year":"2023","unstructured":"Xu, W., Zhang, B., Xi, C., Qin, Y., Lin, X., et al. (2023). Ferroptosis plays a role in human chondrocyte of osteoarthritis induced by IL-1\u03b2 in vitro. Cartilage, 14, 455\u2013466.","journal-title":"Cartilage"},{"key":"2183_CR27","doi-asserted-by":"publisher","first-page":"110148","DOI":"10.1016\/j.cbi.2022.110148","volume":"366","author":"X Wang","year":"2022","unstructured":"Wang, X., Liu, Z., Peng, P., Gong, Z., Huang, J., et al. (2022). Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes. Chemical Biology & Interactions, 366, 110148.","journal-title":"Chemical Biology & Interactions"},{"key":"2183_CR28","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13018-023-04483-0","volume":"19","author":"J Liu","year":"2024","unstructured":"Liu, J., Zhou, H., Chen, J., Zuo, Q., & Liu, F. (2024). Baicalin inhibits IL-1\u03b2-induced ferroptosis in human osteoarthritis chondrocytes by activating Nrf-2 signaling pathway. Journal of Orthopaedic Surgery and Research, 19, 23.","journal-title":"Journal of Orthopaedic Surgery and Research"},{"key":"2183_CR29","doi-asserted-by":"publisher","first-page":"1545339","DOI":"10.3389\/fimmu.2025.1545339","volume":"16","author":"D Sun","year":"2025","unstructured":"Sun, D., Wang, L., Wu, Y., Yu, Y., Yao, Y., et al. (2025). Lipid metabolism in ferroptosis: Mechanistic insights and therapeutic potential. Frontiers in Immunology, 16, 1545339.","journal-title":"Frontiers in Immunology"},{"key":"2183_CR30","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1007\/s00204-023-03476-6","volume":"97","author":"B Wang","year":"2023","unstructured":"Wang, B., Wang, Y., Zhang, J., Hu, C., Jiang, J., et al. (2023). ROS-induced lipid peroxidation modulates cell death outcome: Mechanisms behind apoptosis, autophagy, and ferroptosis. Archives of Toxicology, 97, 1439\u20131451.","journal-title":"Archives of Toxicology"},{"key":"2183_CR31","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","volume":"152","author":"F Ursini","year":"2020","unstructured":"Ursini, F., & Maiorino, M. (2020). Lipid peroxidation and ferroptosis: The role of GSH and GPx4. Free Radical Biology and Medicine, 152, 175\u2013185.","journal-title":"Free Radical Biology and Medicine"},{"key":"2183_CR32","doi-asserted-by":"publisher","first-page":"104258","DOI":"10.1016\/j.ebiom.2022.104258","volume":"84","author":"Z Lv","year":"2022","unstructured":"Lv, Z., Han, J., Li, J., Guo, H., Fei, Y., et al. (2022). Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an anti-ferroptotic target in osteoarthritis. EBioMedicine, 84, 104258.","journal-title":"EBioMedicine"},{"key":"2183_CR33","doi-asserted-by":"publisher","first-page":"1202436","DOI":"10.3389\/fimmu.2023.1202436","volume":"14","author":"S Cao","year":"2023","unstructured":"Cao, S., Wei, Y., Xu, H., Weng, J., Qi, T., et al. (2023). Crosstalk between ferroptosis and chondrocytes in osteoarthritis: A systematic review of in vivo and in vitro studies. Frontiers in Immunology, 14, 1202436.","journal-title":"Frontiers in Immunology"},{"key":"2183_CR34","doi-asserted-by":"publisher","first-page":"21592","DOI":"10.1038\/s41598-023-49089-y","volume":"13","author":"Y Xu","year":"2023","unstructured":"Xu, Y., Yang, Z., Dai, T., Xue, X., Xia, D., et al. (2023). Characteristics and time points to inhibit ferroptosis in human osteoarthritis. Scientific Reports, 13, 21592.","journal-title":"Scientific Reports"},{"key":"2183_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jot.2024.10.005","volume":"50","author":"S Cao","year":"2024","unstructured":"Cao, S., Wei, Y., Xiong, A., Yue, Y., Yang, J., et al. (2024). Paeonol inhibits ACSL4 to protect chondrocytes from ferroptosis and ameliorates osteoarthritis progression. Journal of Orthopaedic Translation, 50, 1\u201313.","journal-title":"Journal of Orthopaedic Translation"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-026-02183-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-026-02183-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-026-02183-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:02:01Z","timestamp":1790373721000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-026-02183-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":35,"alternative-id":["2183"],"URL":"https:\/\/doi.org\/10.1007\/s12013-026-02183-0","relation":{},"ISSN":["1559-0283"],"issn-type":[{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]},"assertion":[{"value":"7 September 2026","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2026","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved (2025-029) by the Nantong Second People\u2019s Hospital Ethics Committee. The authors envisaged all standard protocols in accordance with the 1964 Declaration of Helsinki.","order":1,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}