{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:17:59Z","timestamp":1791249479378,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,3,3]],"date-time":"2010-03-03T00:00:00Z","timestamp":1267574400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stem Cell Rev and Rep"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1007\/s12015-010-9125-6","type":"journal-article","created":{"date-parts":[[2010,3,2]],"date-time":"2010-03-02T05:53:59Z","timestamp":1267509239000},"page":"32-42","source":"Crossref","is-referenced-by-count":63,"title":["Human Bone Marrow Mesenchymal Stem Cells: A Systematic Reappraisal Via the Genostem Experience"],"prefix":"10.1007","volume":"7","author":[{"given":"Pierre","family":"Charbord","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erella","family":"Livne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"H\u00e4upl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno M.","family":"Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Marie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bianco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Jorgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,3,3]]},"reference":[{"key":"9125_CR1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/978-1-59745-443-8_4","volume":"140","author":"B Delorme","year":"2007","unstructured":"Delorme, B., & Charbord, P. (2007). Culture and characterization of human bone marrow mesenchymal stem cells. Methods in Molecular Medicine, 140, 67\u201381.","journal-title":"Methods in Molecular Medicine"},{"issue":"2","key":"9125_CR2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/14653240701851332","volume":"10","author":"H Dimitriou","year":"2008","unstructured":"Dimitriou, H., Linardakis, E., Martimianaki, G., et al. (2008). Properties and potential of bone marrow mesenchymal stromal cells from children with hematologic diseases. Cytotherapy, 10(2), 125\u2013133.","journal-title":"Cytotherapy"},{"issue":"5","key":"9125_CR3","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1002\/stem.34","volume":"27","author":"B Delorme","year":"2009","unstructured":"Delorme, B., Ringe, J., Pontikoglou, C., et al. (2009). Specific lineage-priming of bone marrow mesenchymal stem cells provides the molecular framework for their plasticity. Stem Cells, 27(5), 1142\u20131151.","journal-title":"Stem Cells"},{"issue":"4","key":"9125_CR4","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/sj.leu.2404589","volume":"21","author":"I Peiffer","year":"2007","unstructured":"Peiffer, I., Eid, P., Barbet, R., et al. (2007). A sub-population of high proliferative potential-quiescent human mesenchymal stem cells is under the reversible control of interferon alpha\/beta. Leukemia, 21(4), 714\u2013724.","journal-title":"Leukemia"},{"issue":"5","key":"9125_CR5","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1182\/blood-2007-07-099622","volume":"111","author":"B Delorme","year":"2008","unstructured":"Delorme, B., Ringe, J., Gallay, N., et al. (2008). Specific plasma membrane protein phenotype of culture-amplified and native human bone marrow mesenchymal stem cells. Blood, 111(5), 2631\u20132635.","journal-title":"Blood"},{"issue":"2","key":"9125_CR6","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cell.2007.08.025","volume":"131","author":"B Sacchetti","year":"2007","unstructured":"Sacchetti, B., Funari, A., Michienzi, S., et al. (2007). Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell, 131(2), 324\u2013336.","journal-title":"Cell"},{"issue":"9","key":"9125_CR7","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1634\/stemcells.2008-0304","volume":"26","author":"N Kaltz","year":"2008","unstructured":"Kaltz, N., Funari, A., Hippauf, S., et al. (2008). In vivo osteoprogenitor potency of human stromal cells from different tissues does not correlate with expression of POU5F1 or its pseudogenes. Stem Cells, 26(9), 2419\u20132424.","journal-title":"Stem Cells"},{"issue":"1","key":"9125_CR8","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1182\/blood.V82.1.66.bloodjournal82166","volume":"82","author":"MC Galmiche","year":"1993","unstructured":"Galmiche, M. C., Koteliansky, V. E., Briere, J., Herve, P., & Charbord, P. (1993). Stromal cells from human long-term marrow cultures are mesenchymal cells that differentiate following a vascular smooth muscle differentiation pathway. Blood, 82(1), 66\u201376.","journal-title":"Blood"},{"issue":"12","key":"9125_CR9","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1172\/JCI10413","volume":"105","author":"P Bianco","year":"2000","unstructured":"Bianco, P., & Gehron Robey, P. (2000). Marrow stromal stem cells. J Clin Invest, 105(12), 1663\u20131668.","journal-title":"J Clin Invest"},{"issue":"7","key":"9125_CR10","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1634\/stemcells.2005-0604","volume":"24","author":"L Song","year":"2006","unstructured":"Song, L., Webb, N. E., Song, Y., & Tuan, R. S. (2006). Identification and functional analysis of candidate genes regulating mesenchymal stem cell self-renewal and multipotency. Stem Cells, 24(7), 1707\u20131718.","journal-title":"Stem Cells"},{"issue":"7","key":"9125_CR11","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.cell.2007.04.028","volume":"129","author":"Y Takashima","year":"2007","unstructured":"Takashima, Y., Era, T., Nakao, K., et al. (2007). Neuroepithelial cells supply an initial transient wave of MSC differentiation. Cell, 129(7), 1377\u20131388.","journal-title":"Cell"},{"issue":"9","key":"9125_CR12","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1182\/blood-2006-04-016600","volume":"108","author":"M Ogawa","year":"2006","unstructured":"Ogawa, M., LaRue, A. C., & Drake, C. J. (2006). Hematopoietic origin of fibroblasts\/myofibroblasts: Its pathophysiologic implications. Blood, 108(9), 2893\u20132896.","journal-title":"Blood"},{"issue":"4","key":"9125_CR13","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.stem.2008.03.002","volume":"2","author":"P Bianco","year":"2008","unstructured":"Bianco, P., Robey, P. G., & Simmons, P. J. (2008). Mesenchymal stem cells: revisiting history, concepts, and assays. Cell Stem Cell, 2(4), 313\u2013319.","journal-title":"Cell Stem Cell"},{"issue":"4","key":"9125_CR14","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2217\/17460751.1.4.539","volume":"1","author":"PJ Marie","year":"2006","unstructured":"Marie, P. J., & Fromigue, O. (2006). Osteogenic differentiation of human marrow-derived mesenchymal stem cells. Regen Med, 1(4), 539\u2013548.","journal-title":"Regen Med"},{"issue":"11","key":"9125_CR15","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1096\/fj.08-106302","volume":"22","author":"Z Hamidouche","year":"2008","unstructured":"Hamidouche, Z., Hay, E., Vaudin, P., et al. (2008). FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt\/beta-catenin signaling-dependent Runx2 expression. Faseb Journal, 22(11), 3813\u20133822.","journal-title":"Faseb Journal"},{"key":"9125_CR16","doi-asserted-by":"crossref","unstructured":"Hamidouche, Z., Fromigue, O., Ringe, J., et al. (2009). Priming integrin {alpha}5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis. Proc Natl Acad Sci USA.","DOI":"10.1073\/pnas.0812334106"},{"issue":"3","key":"9125_CR17","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1089\/clo.2009.0013","volume":"11","author":"F Djouad","year":"2009","unstructured":"Djouad, F., Bony, C., Canovas, F., et al. (2009). Transcriptomic analysis identifies Foxo3A as a novel transcription factor regulating mesenchymal stem cell chrondrogenic differentiation. Cloning Stem Cells, 11(3), 407\u2013416.","journal-title":"Cloning Stem Cells"},{"issue":"2","key":"9125_CR18","doi-asserted-by":"crossref","first-page":"R33","DOI":"10.1186\/ar2153","volume":"9","author":"F Djouad","year":"2007","unstructured":"Djouad, F., Delorme, B., Maurice, M., et al. (2007). Microenvironmental changes during differentiation of mesenchymal stem cells towards chondrocytes. Arthritis Research and Therapy, 9(2), R33.","journal-title":"Arthritis Research and Therapy"},{"issue":"1","key":"9125_CR19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1089\/clo.2008.0070","volume":"11","author":"D Mrugala","year":"2009","unstructured":"Mrugala, D., Dossat, N., Ringe, J., et al. (2009). Gene expression profile of multipotent mesenchymal stromal cells: Identification of pathways common to TGFbeta3\/BMP2-induced chondrogenesis. Cloning Stem Cells, 11(1), 61\u201376.","journal-title":"Cloning Stem Cells"},{"issue":"2","key":"9125_CR20","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1197\/j.jht.2005.01.009","volume":"18","author":"MI Boyer","year":"2005","unstructured":"Boyer, M. I., Goldfarb, C. A., & Gelberman, R. H. (2005). Recent progress in flexor tendon healing. The modulation of tendon healing with rehabilitation variables. Journal of Hand Therapy, 18(2), 80\u201385. quiz 6.","journal-title":"Journal of Hand Therapy"},{"issue":"4","key":"9125_CR21","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1172\/JCI22689","volume":"116","author":"A Hoffmann","year":"2006","unstructured":"Hoffmann, A., Pelled, G., Turgeman, G., et al. (2006). Neotendon formation induced by manipulation of the Smad8 signalling pathway in mesenchymal stem cells. Journal of Clinical Investigation, 116(4), 940\u2013952.","journal-title":"Journal of Clinical Investigation"},{"issue":"3","key":"9125_CR22","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/mabi.200600233","volume":"7","author":"VM Correlo","year":"2007","unstructured":"Correlo, V. M., Pinho, E. D., Pashkuleva, I., Bhattacharya, M., Neves, N. M., & Reis, R. L. (2007). Water absorption and degradation characteristics of chitosan-based polyesters and hydroxyapatite composites. Macromolecular Bioscience, 7(3), 354\u2013363.","journal-title":"Macromolecular Bioscience"},{"issue":"6","key":"9125_CR23","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1089\/ten.tea.2007.0153","volume":"14","author":"AR Costa-Pinto","year":"2008","unstructured":"Costa-Pinto, A. R., Salgado, A. J., Correlo, V. M., et al. (2008). Adhesion, proliferation, and osteogenic differentiation of a mouse mesenchymal stem cell line (BMC9) seeded on novel melt-based chitosan\/polyester 3D porous scaffolds. Tissue Engineering Part A, 14(6), 1049\u20131057.","journal-title":"Tissue Engineering Part A"},{"issue":"10","key":"9125_CR24","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1089\/ten.tea.2007.0307","volume":"14","author":"JT Oliveira","year":"2008","unstructured":"Oliveira, J. T., Correlo, V. M., Sol, P. C., et al. (2008). Assessment of the suitability of chitosan\/polybutylene succinate scaffolds seeded with mouse mesenchymal progenitor cells for a cartilage tissue engineering approach. Tissue Engineering Part A, 14(10), 1651\u20131661.","journal-title":"Tissue Engineering Part A"},{"key":"9125_CR25","doi-asserted-by":"crossref","unstructured":"Costa-Pinto, A. R., Correlo, V. M., & Sol, P. C., et al. (2009).Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells Seeded on Melt Based Chitosan Scaffolds for Bone Tissue Engineering Applications. Biomacromolecules, 10(8), 2067\u20132073.","DOI":"10.1021\/bm9000102"},{"issue":"17","key":"9125_CR26","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1016\/j.biomaterials.2007.02.011","volume":"28","author":"I Roman","year":"2007","unstructured":"Roman, I., Vilalta, M., Rodriguez, J., et al. (2007). Analysis of progenitor cell-scaffold combinations by in vivo non-invasive photonic imaging. Biomaterials, 28(17), 2718\u20132728.","journal-title":"Biomaterials"},{"issue":"2","key":"9125_CR27","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s00223-008-9202-x","volume":"84","author":"S Srouji","year":"2009","unstructured":"Srouji, S., Kizhner, T., Ben David, D., Riminucci, M., Bianco, P., & Livne, E. (2009). The Schneiderian membrane contains osteoprogenitor cells: in vivo and in vitro study. Calcified Tissue International, 84(2), 138\u2013145.","journal-title":"Calcified Tissue International"},{"issue":"3","key":"9125_CR28","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1136\/ard.2007.076620","volume":"67","author":"D Mrugala","year":"2008","unstructured":"Mrugala, D., Bony, C., Neves, N., et al. (2008). Phenotypic and functional characterisation of ovine mesenchymal stem cells: application to a cartilage defect model. Annals of the Rheumatic Diseases, 67(3), 288\u2013295.","journal-title":"Annals of the Rheumatic Diseases"},{"key":"9125_CR29","doi-asserted-by":"crossref","unstructured":"Snedeker, J. G., Arav, A. B., Zilberman, Y., Pelled, G., & Gazit, D. (2009). Functional Fibered Confocal Microscopy: A Promising Tool for Assessing Tendon Regeneration. Tissue Eng Part C Methods, 15(3), 485\u2013491.","DOI":"10.1089\/ten.tec.2008.0612"},{"key":"9125_CR30","doi-asserted-by":"crossref","unstructured":"Snedeker, J. G., Pelled, G., Zilberman, Y., et al. (2008). An Analytical Model for Elucidating Tendon Tissue Structure and Biomechanical Function from in vivo Cellular Confocal Microscopy Images. Cells Tissues Organs, 190(2), 111\u2013119.","DOI":"10.1159\/000189211"},{"issue":"6","key":"9125_CR31","doi-asserted-by":"crossref","first-page":"064010","DOI":"10.1117\/1.2393153","volume":"11","author":"JG Snedeker","year":"2006","unstructured":"Snedeker, J. G., Pelled, G., Zilberman, Y., Gerhard, F., Muller, R., & Gazit, D. (2006). Endoscopic cellular microscopy for in vivo biomechanical assessment of tendon function. Journal of Biomedical Optics, 11(6), 064010.","journal-title":"Journal of Biomedical Optics"},{"issue":"4","key":"9125_CR32","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.stem.2007.09.014","volume":"1","author":"PH Jones","year":"2007","unstructured":"Jones, P. H., Simons, B. D., & Watt, F. M. (2007). Sic transit gloria: farewell to the epidermal transit amplifying cell? Cell Stem Cell, 1(4), 371\u2013381.","journal-title":"Cell Stem Cell"},{"issue":"6","key":"9125_CR33","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1634\/stemcells.2005-0030","volume":"23","author":"D Zipori","year":"2005","unstructured":"Zipori, D. (2005). The stem state: plasticity is essential, whereas self-renewal and hierarchy are optional. Stem Cells, 23(6), 719\u2013726.","journal-title":"Stem Cells"},{"issue":"5","key":"9125_CR34","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/bies.200800189","volume":"31","author":"S Huang","year":"2009","unstructured":"Huang, S. (2009). Reprogramming cell fates: reconciling rarity with robustness. Bioessays, 31(5), 546\u2013560.","journal-title":"Bioessays"},{"issue":"5732","key":"9125_CR35","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1126\/science.1110364","volume":"309","author":"M Dezawa","year":"2005","unstructured":"Dezawa, M., Ishikawa, H., Itokazu, Y., et al. (2005). Bone marrow stromal cells generate muscle cells and repair muscle degeneration. Science, 309(5732), 314\u2013317.","journal-title":"Science"},{"issue":"12","key":"9125_CR36","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1172\/JCI200420935","volume":"113","author":"M Dezawa","year":"2004","unstructured":"Dezawa, M., Kanno, H., Hoshino, M., et al. (2004). Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. Journal of Clinical Investigation, 113(12), 1701\u20131710.","journal-title":"Journal of Clinical Investigation"},{"issue":"1","key":"9125_CR37","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.stem.2007.05.012","volume":"1","author":"S Yamanaka","year":"2007","unstructured":"Yamanaka, S. (2007). Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell, 1(1), 39\u201349.","journal-title":"Cell Stem Cell"},{"issue":"5","key":"9125_CR38","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nrm2146","volume":"8","author":"JM Slack","year":"2007","unstructured":"Slack, J. M. (2007). Metaplasia and transdifferentiation: from pure biology to the clinic. Nature Reviews Molecular Cell Biology, 8(5), 369\u2013378.","journal-title":"Nature Reviews Molecular Cell Biology"},{"issue":"4","key":"9125_CR39","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","volume":"126","author":"AJ Engler","year":"2006","unstructured":"Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006). Matrix elasticity directs stem cell lineage specification. Cell, 126(4), 677\u2013689.","journal-title":"Cell"},{"issue":"8","key":"9125_CR40","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1002\/stem.103","volume":"27","author":"F Granero-Molto","year":"2009","unstructured":"Granero-Molto, F., Weis, J. A., Miga, M. I., et al. (2009). Regenerative effects of transplanted mesenchymal stem cells in fracture healing. Stem Cells, 27(8), 1887\u20131898.","journal-title":"Stem Cells"},{"issue":"12","key":"9125_CR41","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/01.CIR.0000124062.31102.57","volume":"109","author":"T Kinnaird","year":"2004","unstructured":"Kinnaird, T., Stabile, E., Burnett, M. S., et al. (2004). Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation, 109(12), 1543\u20131549.","journal-title":"Circulation"},{"issue":"9","key":"9125_CR42","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1634\/stemcells.2007-1122","volume":"26","author":"L Silva Meirelles da","year":"2008","unstructured":"da Silva Meirelles, L., Caplan, A. I., & Nardi, N. B. (2008). In search of the in vivo identity of mesenchymal stem cells. Stem Cells, 26(9), 2287\u20132299.","journal-title":"Stem Cells"},{"issue":"7","key":"9125_CR43","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.yexcr.2007.12.022","volume":"314","author":"D Noel","year":"2008","unstructured":"Noel, D., Caton, D., Roche, S., et al. (2008). Cell specific differences between human adipose-derived and mesenchymal-stromal cells despite similar differentiation potentials. Experimental Cell Research, 314(7), 1575\u20131584.","journal-title":"Experimental Cell Research"},{"issue":"4","key":"9125_CR44","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1172\/JCI28320","volume":"116","author":"DA Towler","year":"2006","unstructured":"Towler, D. A., & Gelberman, R. H. (2006). The alchemy of tendon repair: a primer for the (S)mad scientist. Journal of Clinical Investigation, 116(4), 863\u2013866.","journal-title":"Journal of Clinical Investigation"}],"container-title":["Stem Cell Reviews and Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-010-9125-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12015-010-9125-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-010-9125-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T19:16:49Z","timestamp":1590693409000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12015-010-9125-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,3]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["9125"],"URL":"https:\/\/doi.org\/10.1007\/s12015-010-9125-6","relation":{},"ISSN":["1550-8943","1558-6804"],"issn-type":[{"value":"1550-8943","type":"print"},{"value":"1558-6804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,3]]}}}