{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:47:27Z","timestamp":1791276447463,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stem Cell Rev and Rep"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1007\/s12015-010-9209-3","type":"journal-article","created":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T09:24:52Z","timestamp":1291109092000},"page":"331-341","source":"Crossref","is-referenced-by-count":64,"title":["A Cyclic AMP Analog, 8-Br-cAMP, Enhances the Induction of Pluripotency in Human Fibroblast Cells"],"prefix":"10.1007","volume":"7","author":[{"given":"Ying","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Adjaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,12,1]]},"reference":[{"issue":"4","key":"9209_CR1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","volume":"126","author":"K Takahashi","year":"2006","unstructured":"Takahashi, K., & Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126(4), 663\u2013676.","journal-title":"Cell"},{"issue":"10","key":"9209_CR2","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/nbt1335","volume":"25","author":"A Meissner","year":"2007","unstructured":"Meissner, A., Wernig, M., & Jaenisch, R. (2007). Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol, 25(10), 1177\u20131181.","journal-title":"Nat Biotechnol"},{"issue":"5","key":"9209_CR3","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","volume":"131","author":"K Takahashi","year":"2007","unstructured":"Takahashi, K., Tanabe, K., Ohnuki, M., et al. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 131(5), 861\u2013872.","journal-title":"Cell"},{"issue":"5858","key":"9209_CR4","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1126\/science.1151526","volume":"318","author":"J Yu","year":"2007","unstructured":"Yu, J., Vodyanik, M. A., Smuga-Otto, K., et al. (2007). Induced pluripotent stem cell lines derived from human somatic cells. Science, 318(5858), 1917\u20131920.","journal-title":"Science"},{"issue":"5893","key":"9209_CR5","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1126\/science.1158799","volume":"321","author":"JT Dimos","year":"2008","unstructured":"Dimos, J. T., Rodolfa, K. T., Niakan, K. K., et al. (2008). Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science, 321(5893), 1218\u20131221.","journal-title":"Science"},{"issue":"5","key":"9209_CR6","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.cell.2008.07.041","volume":"134","author":"IH Park","year":"2008","unstructured":"Park, I. H., Arora, N., Huo, H., et al. (2008). Disease-specific induced pluripotent stem cells. Cell, 134(5), 877\u2013886.","journal-title":"Cell"},{"issue":"7227","key":"9209_CR7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature07677","volume":"457","author":"AD Ebert","year":"2009","unstructured":"Ebert, A. D., Yu, J., Rose, F. F., Jr., et al. (2009). Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature, 457(7227), 277\u2013280.","journal-title":"Nature"},{"issue":"5","key":"9209_CR8","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.cell.2009.02.013","volume":"136","author":"F Soldner","year":"2009","unstructured":"Soldner, F., Hockemeyer, D., Beard, C., et al. (2009). Parkinson\u2019s disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell, 136(5), 964\u2013977.","journal-title":"Cell"},{"issue":"7251","key":"9209_CR9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature08129","volume":"460","author":"A Raya","year":"2009","unstructured":"Raya, A., Rodr\u00edguez-Piz\u00e0, I., Guenechea, G., et al. (2009). Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature, 460(7251), 53\u201359.","journal-title":"Nature"},{"issue":"11","key":"9209_CR10","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/cr.2009.107","volume":"19","author":"Z Song","year":"2009","unstructured":"Song, Z., Cai, J., Liu, Y., et al. (2009). Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res, 19(11), 1233\u20131242.","journal-title":"Cell Res"},{"issue":"1","key":"9209_CR11","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/hep.23354","volume":"51","author":"K Si-Tayeb","year":"2010","unstructured":"Si-Tayeb, K., Noto, F. K., Nagaoka, M., et al. (2010). Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. Hepatology, 51(1), 297\u2013305.","journal-title":"Hepatology"},{"issue":"1","key":"9209_CR12","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/hep.23335","volume":"51","author":"GJ Sullivan","year":"2010","unstructured":"Sullivan, G. J., Hay, D. C., Park, I. H., et al. (2010). Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology, 51(1), 329\u2013335.","journal-title":"Hepatology"},{"issue":"4","key":"9209_CR13","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1161\/CIRCRESAHA.108.192237","volume":"104","author":"J Zhang","year":"2009","unstructured":"Zhang, J., Wilson, G. F., Soerens, A. G., et al. (2009). Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res, 104(4), e30\u2013e41.","journal-title":"Circ Res"},{"issue":"4","key":"9209_CR14","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/cr.2009.28","volume":"19","author":"D Zhang","year":"2009","unstructured":"Zhang, D., Jiang, W., Liu, M., et al. (2009). Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res, 19(4), 429\u2013438.","journal-title":"Cell Res"},{"issue":"3","key":"9209_CR15","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1634\/stemcells.2008-0922","volume":"27","author":"KD Choi","year":"2009","unstructured":"Choi, K. D., Yu, J., Smuga-Otto, K., et al. (2009). Hematopoietic and endothelial differentiation of human induced pluripotent stem cells. Stem Cells, 27(3), 559\u2013567.","journal-title":"Stem Cells"},{"issue":"6","key":"9209_CR16","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.febslet.2009.02.031","volume":"583","author":"D Taura","year":"2009","unstructured":"Taura, D., Noguchi, M., Sone, M., et al. (2009). Adipogenic differentiation of human induced pluripotent stem cells: Comparison with that of human embryonic stem cells. FEBS Lett, 583(6), 1029\u20131033.","journal-title":"FEBS Lett"},{"issue":"3","key":"9209_CR17","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nbt.1529","volume":"27","author":"SM Chambers","year":"2009","unstructured":"Chambers, S. M., Fasano, C. A., Papapetrou, E. P., Tomishima, M., Sadelain, M., & Studer, L. (2009). Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotechnol, 27(3), 275\u2013280.","journal-title":"Nat Biotechnol"},{"issue":"7200","key":"9209_CR18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nature07056","volume":"454","author":"TS Mikkelsen","year":"2008","unstructured":"Mikkelsen, T. S., Hanna, J., Zhang, X., et al. (2008). Dissecting direct reprogramming through integrative genomic analysis. Nature, 454(7200), 49\u201355.","journal-title":"Nature"},{"issue":"7","key":"9209_CR19","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/nbt1418","volume":"26","author":"D Huangfu","year":"2008","unstructured":"Huangfu, D., Maehr, R., Guo, W., et al. (2008). Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol, 26(7), 795\u2013797.","journal-title":"Nat Biotechnol"},{"issue":"5","key":"9209_CR20","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.stem.2008.10.004","volume":"3","author":"Y Shi","year":"2008","unstructured":"Shi, Y., Desponts, C., Do, J. T., Hahm, H. S., Sch\u00f6ler, H. R., & Ding, S. (2008). Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell, 3(5), 568\u2013574.","journal-title":"Cell Stem Cell"},{"issue":"6","key":"9209_CR21","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.stem.2008.05.011","volume":"2","author":"Y Shi","year":"2008","unstructured":"Shi, Y., Do, J. T., Desponts, C., Hahm, H. S., Sch\u00f6ler, H. R., & Ding, S. (2008). A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell, 2(6), 525\u2013528.","journal-title":"Cell Stem Cell"},{"issue":"1","key":"9209_CR22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.stem.2009.12.001","volume":"6","author":"MA Esteban","year":"2010","unstructured":"Esteban, M. A., Wang, T., Qin, B., et al. (2010). Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell, 6(1), 71\u201379.","journal-title":"Cell Stem Cell"},{"issue":"2","key":"9209_CR23","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s12015-010-9137-2","volume":"6","author":"Y Wang","year":"2010","unstructured":"Wang, Y., Mah, N., Prigione, A., Wolfrum, K., Andrade-Navarro, M. A., & Adjaye, J. (2010). A transcriptional roadmap to the induction of pluripotency in somatic cells. Stem Cell Rev, 6(2), 282\u2013296.","journal-title":"Stem Cell Rev"},{"issue":"11","key":"9209_CR24","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/nbt.1502","volume":"26","author":"D Huangfu","year":"2008","unstructured":"Huangfu, D., Osafune, K., Maehr, R., et al. (2008). Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol, 26(11), 1269\u20131275.","journal-title":"Nat Biotechnol"},{"issue":"11","key":"9209_CR25","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nmeth.1393","volume":"6","author":"T Lin","year":"2009","unstructured":"Lin, T., Ambasudhan, R., Yuan, X., et al. (2009). A chemical platform for improved induction of human iPSCs. Nat Methods, 6(11), 805\u2013808.","journal-title":"Nat Methods"},{"issue":"2","key":"9209_CR26","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1634\/stemcells.2006-0426","volume":"25","author":"Y Babaie","year":"2007","unstructured":"Babaie, Y., Herwig, R., Greber, B., et al. (2007). Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells. Stem Cells, 25(2), 500\u2013510.","journal-title":"Stem Cells"},{"issue":"5","key":"9209_CR27","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.stem.2008.10.002","volume":"3","author":"Y Zhao","year":"2008","unstructured":"Zhao, Y., Yin, X., Qin, H., et al. (2008). Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell, 3(5), 475\u2013479.","journal-title":"Cell Stem Cell"},{"issue":"7259","key":"9209_CR28","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/nature08235","volume":"460","author":"H Hong","year":"2009","unstructured":"Hong, H., Takahashi, K., Ichisaka, T., et al. (2009). Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature, 460(7259), 1132\u20131135.","journal-title":"Nature"},{"issue":"7259","key":"9209_CR29","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/nature08290","volume":"460","author":"H Li","year":"2009","unstructured":"Li, H., Collado, M., Villasante, A., et al. (2009). The Ink4\/Arf locus is a barrier for iPS cell reprogramming. Nature, 460(7259), 1136\u20131139.","journal-title":"Nature"},{"issue":"7259","key":"9209_CR30","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/nature08311","volume":"460","author":"T Kawamura","year":"2009","unstructured":"Kawamura, T., Suzuki, J., Wang, Y. V., et al. (2009). Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature, 460(7259), 1140\u20131144.","journal-title":"Nature"},{"issue":"7259","key":"9209_CR31","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/nature08285","volume":"460","author":"J Utikal","year":"2009","unstructured":"Utikal, J., Polo, J. M., Stadtfeld, M., et al. (2009). Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature, 460(7259), 1145\u20131148.","journal-title":"Nature"},{"issue":"7259","key":"9209_CR32","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/nature08287","volume":"460","author":"RM Mari\u00f3n","year":"2009","unstructured":"Mari\u00f3n, R. M., Strati, K., Li, H., et al. (2009). A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature, 460(7259), 1149\u20131153.","journal-title":"Nature"},{"issue":"7175","key":"9209_CR33","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nature06534","volume":"451","author":"IH Park","year":"2008","unstructured":"Park, I. H., Zhao, R., West, J. A., et al. (2008). Reprogramming of human somatic cells to pluripotency with defined factors. Nature, 451(7175), 141\u2013146.","journal-title":"Nature"},{"issue":"4","key":"9209_CR34","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/stem.404","volume":"28","author":"A Prigione","year":"2010","unstructured":"Prigione, A., Fauler, B., Lurz, R., Lehrach, H., & Adjaye, J. (2010). The senescence-related mitochondrial\/oxidative stress pathway is repressed in human induced pluripotent stem cells. Stem Cells, 28(4), 721\u2013733.","journal-title":"Stem Cells"},{"issue":"1","key":"9209_CR35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1432-1033.1989.tb14689.x","volume":"181","author":"D Ogreid","year":"1989","unstructured":"Ogreid, D., Ekanger, R., Suva, R. H., Miller, J. P., & D\u00f8skeland, S. O. (1989). Comparison of the two classes of binding sites (A and B) of type I and type II cyclic-AMP-dependent protein kinases by using cyclic nucleotide analogs. Eur J Biochem, 181(1), 19\u201331.","journal-title":"Eur J Biochem"},{"issue":"2","key":"9209_CR36","first-page":"165","volume":"78","author":"TC Chen","year":"1998","unstructured":"Chen, T. C., Hinton, D. R., Zidovetzki, R., & Hofman, F. M. (1998). Up-regulation of the cAMP\/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab Invest, 78(2), 165\u2013174.","journal-title":"Lab Invest"},{"issue":"41","key":"9209_CR37","doi-asserted-by":"crossref","first-page":"6538","DOI":"10.3748\/wjg.v11.i41.6538","volume":"11","author":"HM Wang","year":"2005","unstructured":"Wang, H. M., Zheng, N. G., Wu, J. L., Gong, C. C., & Wang, Y. L. (2005). Dual effects of 8-Br-cAMP on differentiation and apoptosis of human esophageal cancer cell line Eca-109. World J Gastroenterol, 11(41), 6538\u20136542.","journal-title":"World J Gastroenterol"},{"key":"9209_CR38","doi-asserted-by":"crossref","unstructured":"Warren, L., Manos, P. D., Ahfeldt, T., et al. (2010). Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modifed mRNA. Cell Stem Cell. [Epub ahead of print].","DOI":"10.1016\/j.stem.2010.08.012"},{"issue":"6","key":"9209_CR39","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.stem.2008.05.010","volume":"2","author":"SC Desbordes","year":"2008","unstructured":"Desbordes, S. C., Placantonakis, D. G., Ciro, A., et al. (2008). High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell, 2(6), 602\u2013612.","journal-title":"Cell Stem Cell"},{"issue":"2","key":"9209_CR40","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/jcp.21967","volume":"222","author":"KA Becker","year":"2010","unstructured":"Becker, K. A., Ghule, P. N., Lian, J. B., Stein, J. L., van Wijnen, A. J., & Stein, G. S. (2010). Cyclin D2 and the CDK substrate p220 (NPAT) are required for self-renewal of human embryonic stem cells. J Cell Physiol, 222(2), 456\u2013464.","journal-title":"J Cell Physiol"}],"container-title":["Stem Cell Reviews and Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-010-9209-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12015-010-9209-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-010-9209-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T17:16:16Z","timestamp":1559841376000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12015-010-9209-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,1]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["9209"],"URL":"https:\/\/doi.org\/10.1007\/s12015-010-9209-3","relation":{},"ISSN":["1550-8943","1558-6804"],"issn-type":[{"value":"1550-8943","type":"print"},{"value":"1558-6804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,1]]}}}