{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:01:08Z","timestamp":1740142868810,"version":"3.37.3"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T00:00:00Z","timestamp":1483747200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS071956"],"award-info":[{"award-number":["R01NS071956"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Rev and Rep"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s12015-016-9716-y","type":"journal-article","created":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T06:04:02Z","timestamp":1483769042000},"page":"192-197","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Stem Cell Recipes of Bone Marrow and Fish: Just What the Stroke Doctors Ordered"],"prefix":"10.1007","volume":"13","author":[{"given":"Eleonora","family":"Napoli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar V.","family":"Borlongan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,1,7]]},"reference":[{"key":"9716_CR1","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1002\/stem.430","volume":"28","author":"JS Lee","year":"2010","unstructured":"Lee, J. S., Hong, J. M., Moon, G. J., et al. (2010). A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke. Stem Cells, 28, 1099\u20131106.","journal-title":"Stem Cells"},{"key":"9716_CR2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/ana.22458","volume":"70","author":"SI Savitz","year":"2011","unstructured":"Savitz, S. I., Misra, V., Kasam, M., et al. (2011). Intravenous autologous bone marrow mononuclear cells for ischemic stroke. Annals of Neurology, 70, 59\u201369.","journal-title":"Annals of Neurology"},{"key":"9716_CR3","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1161\/STROKEAHA.114.007028","volume":"45","author":"K Prasad","year":"2014","unstructured":"Prasad, K., Sharma, A., Garg, A., et al. (2014). Intravenous autologous bone marrow mononuclear stem cell therapy for ischemic stroke: a multicentric, randomized trial. Stroke, 45, 3618\u20133624.","journal-title":"Stroke"},{"key":"9716_CR4","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.5966\/sctm.2013-0178","volume":"3","author":"S Banerjee","year":"2014","unstructured":"Banerjee, S., Bentley, P., Hamady, M., et al. (2014). Intra-arterial immunoselected CD34+ stem cells for acute ischemic stroke. Stem Cell Transl Med, 3, 1322\u20131330.","journal-title":"Stem Cell Transl Med"},{"key":"9716_CR5","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0140-6736(16)30513-X","volume":"388","author":"D Kalladka","year":"2016","unstructured":"Kalladka, D., Sinden, J., Pollock, K., et al. (2016). Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study. Lancet, 388, 787\u2013796.","journal-title":"Lancet"},{"key":"9716_CR6","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1161\/STROKEAHA.116.012995","volume":"47","author":"GK Steinberg","year":"2016","unstructured":"Steinberg, G. K., Kondziolka, D., Wechsler, L. R., et al. (2016). Clinical outcomes of transplanted modified bone marrow-derived mesenchymal stem cells in stroke: a phase 1\/2A study. Stroke, 47, 1817\u20131824.","journal-title":"Stroke"},{"key":"9716_CR7","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/ana.21412","volume":"63","author":"SC Cramer","year":"2008","unstructured":"Cramer, S. C. (2008). Repairing the human brain after stroke. II. Restorative therapies. Annals of Neurology, 63, 549\u2013560.","journal-title":"Annals of Neurology"},{"key":"9716_CR8","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1038\/jcbfm.2014.94","volume":"34","author":"J Boltze","year":"2014","unstructured":"Boltze, J., Lukomska, B., Jolkkonen, J., et al. (2014). Mesenchymal stromal cells in stroke: improvement of motor recovery or functional compensation? Journal of Cerebral Blood Flow and Metabolism, 34, 1420\u20131421.","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"9716_CR9","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/ana.60000","volume":"52","author":"SI Savitz","year":"2002","unstructured":"Savitz, S. I., Rosenbaum, D. M., Dinsmore, J. H., Wechsler, L. R., & Caplan, L. R. (2002). Cell transplantation for stroke. Annals of Neurology, 52, 266\u2013275.","journal-title":"Annals of Neurology"},{"key":"9716_CR10","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1161\/STROKEAHA.110.601914","volume":"42","author":"SI Savitz","year":"2011","unstructured":"Savitz, S. I., Chopp, M., Deans, R., et al. (2011). Stem cell therapy as an emerging paradigm for stroke (STEPS) II. Stroke, 42, 825\u2013829.","journal-title":"Stroke"},{"key":"9716_CR11","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1161\/STROKEAHA.113.003379","volume":"45","author":"SI Savitz","year":"2014","unstructured":"Savitz, S. I., Cramer, S. C., Wechsler, L., et al. (2014). Stem cells as an emerging paradigm in stroke 3: enhancing the development of clinical trials. Stroke, 45, 634\u2013639.","journal-title":"Stroke"},{"key":"9716_CR12","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1161\/STROKEAHA.114.007105","volume":"46","author":"T Diamandis","year":"2015","unstructured":"Diamandis, T., & Borlongan, C. V. (2015). One, two, three steps toward cell therapy for stroke. Stroke, 46, 588\u2013591.","journal-title":"Stroke"},{"key":"9716_CR13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0043779","volume":"7","author":"N Tajiri","year":"2012","unstructured":"Tajiri, N., Acosta, S., Glover, L. E., et al. (2012). Intravenous grafts of amniotic fluid-derived stem cells induce endogenous cell proliferation and attenuate behavioral deficits in ischemic stroke rats. PloS One, 7, e43779.","journal-title":"PloS One"},{"key":"9716_CR14","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.pneurobio.2008.04.005","volume":"85","author":"K Hara","year":"2008","unstructured":"Hara, K., Yasuhara, T., Maki, M., et al. (2008). Neural progenitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke. Progress in Neurobiology, 85, 318\u2013334.","journal-title":"Progress in Neurobiology"},{"key":"9716_CR15","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1600-079X.2010.00837.x","volume":"50","author":"Y Kaneko","year":"2011","unstructured":"Kaneko, Y., Hayashi, T., Yu, S., et al. (2011). Human amniotic epithelial cells express melatonin receptor MT1, but not melatonin receptor MT2: a new perspective to neuroprotection. Journal of Pineal Research, 50, 272\u2013280.","journal-title":"Journal of Pineal Research"},{"key":"9716_CR16","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/stem.2206","volume":"34","author":"H Uchida","year":"2016","unstructured":"Uchida, H., Morita, T., Niizuma, K., et al. (2016). Transplantation of unique subpopulation of fibroblasts, muse cells, ameliorates experimental stroke possibly via robust neuronal differentiation. Stem Cells, 34, 160\u2013173.","journal-title":"Stem Cells"},{"key":"9716_CR17","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1089\/scd.2013.0182","volume":"23","author":"SP Liu","year":"2014","unstructured":"Liu, S. P., Fu, R. H., Wu, D. C., et al. (2014). Mouse-induced pluripotent stem cells generated under hypoxic conditions in the absence of viral infection and oncogenic factors and used for ischemic stroke therapy. Stem Cells and Development, 23, 421\u2013433.","journal-title":"Stem Cells and Development"},{"key":"9716_CR18","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1177\/1545968309335978","volume":"23","author":"P Stroemer","year":"2009","unstructured":"Stroemer, P., Patel, S., Hope, A., et al. (2009). The neural stem cell line CTX0E03 promotes behavioral recovery and endogenous neurogenesis after experimental stroke in a dose-dependent fashion. Neurorehabilitation and Neural Repair, 23, 895\u2013909.","journal-title":"Neurorehabilitation and Neural Repair"},{"key":"9716_CR19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0127302","volume":"10","author":"A Toyoshima","year":"2015","unstructured":"Toyoshima, A., Yasuhara, T., Kameda, M., et al. (2015). Intra-arterial transplantation of allogeneic mesenchymal stem cells mounts neuroprotective effects in a transient ischemic stroke model in rats: analyses of therapeutic time window and its mechanisms. PloS One, 10, e0127302.","journal-title":"PloS One"},{"key":"9716_CR20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.pneurobio.2011.08.005","volume":"95","author":"CV Borlongan","year":"2011","unstructured":"Borlongan, C. V., Glover, L. E., Tajiri, N., et al. (2011). The great migration of bone marrow-derived stem cells toward the ischemic brain: therapeutic implications for stroke and other neurological disorders. Progress in Neurobiology, 95, 213\u2013228.","journal-title":"Progress in Neurobiology"},{"key":"9716_CR21","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1038\/leu.2011.167","volume":"25","author":"CV Borlongan","year":"2011","unstructured":"Borlongan, C. V. (2011). Bone marrow stem cell mobilization in stroke: a \u2018bonehead\u2019 may be good after all! Leukemia, 25, 1674\u20131686.","journal-title":"Leukemia"},{"key":"9716_CR22","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1038\/jcbfm.2011.116","volume":"31","author":"H Xin","year":"2011","unstructured":"Xin, H., Li, Y., Shen, L. H., et al. (2011). Multipotent mesenchymal stromal cells increase tPA expression and concomitantly decrease PAI-1 expression in astrocytes through the sonic hedgehog signaling pathway after stroke (in vitro study). Journal of Cerebral Blood Flow and Metabolism, 31, 2181\u20132188.","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"9716_CR23","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1161\/STROKEAHA.115.009854","volume":"46","author":"SA Acosta","year":"2015","unstructured":"Acosta, S. A., Tajiri, N., Hoover, J., et al. (2015). Intravenous bone marrow stem cell grafts preferentially migrate to spleen and abrogate chronic inflammation in stroke. Stroke, 46, 2616\u20132627.","journal-title":"Stroke"},{"key":"9716_CR24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093735","volume":"9","author":"DR Yavagal","year":"2014","unstructured":"Yavagal, D. R., Lin, B., Raval, A. P., et al. (2014). Efficacy and dose-dependent safety of intra-arterial delivery of mesenchymal stem cells in a rodent stroke model. PloS One, 9, e93735.","journal-title":"PloS One"},{"key":"9716_CR25","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/jcbfm.2013.91","volume":"33","author":"MA Eckert","year":"2013","unstructured":"Eckert, M. A., Vu, Q., Xie, K., et al. (2013). Evidence for high translational potential of mesenchymal stromal cell therapy to improve recovery from ischemic stroke. Journal of Cerebral Blood Flow and Metabolism, 33, 1322\u20131334.","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"9716_CR26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/B978-0-444-59544-7.00005-6","volume":"201","author":"JD Kocsis","year":"2012","unstructured":"Kocsis, J. D., & Honmou, O. (2012). Bone marrow stem cells in experimental stroke. Progress in Brain Research, 201, 79\u201398.","journal-title":"Progress in Brain Research"},{"key":"9716_CR27","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1002\/jnr.22501","volume":"88","author":"H Xu","year":"2010","unstructured":"Xu, H., Miki, K., Ishibashi, S., et al. (2010). Transplantation of neuronal cells induced from human mesenchymal stem cells improves neurological functions after stroke without cell fusion. Journal of Neuroscience Research, 88, 3598\u20133609.","journal-title":"Journal of Neuroscience Research"},{"key":"9716_CR28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3389\/fncel.2014.00207","volume":"8","author":"CT Velthoven van","year":"2014","unstructured":"van Velthoven, C. T., Gonzalez, F., Vexler, Z. S., et al. (2014). Stem cells for neonatal stroke- the future is here. Frontiers in Cellular Neuroscience, 8, 207.","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"9716_CR29","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.pneurobio.2013.11.007","volume":"115","author":"X Liu","year":"2014","unstructured":"Liu, X., Ye, R., Yan, T., et al. (2014). Cell based therapies for ischemic stroke: from basic science to bedside. Progress in Neurobiology, 115, 92\u2013115.","journal-title":"Progress in Neurobiology"},{"key":"9716_CR30","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1038\/jcbfm.2014.94","volume":"34","author":"J Boltze","year":"2014","unstructured":"Boltze, J., Lukomska, B., Jolkkonen, J., & MEMS\u2013IRBI consortium. (2014). Mesenchymal stromal cells in stroke: improvement of motor recovery or functional compensation? Journal of Cerebral Blood Flow and Metabolism, 34, 1420\u20131421.","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"9716_CR31","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.5966\/sctm.2015-0078","volume":"4","author":"TR Doeppner","year":"2015","unstructured":"Doeppner, T. R., Herz, J., G\u00f6rgens, A., et al. (2015). Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression. Stem Cells Transl Med, 4, 1131\u20131143.","journal-title":"Stem Cells Transl Med"},{"key":"9716_CR32","first-page":"298","volume":"11","author":"Y Xiong","year":"2010","unstructured":"Xiong, Y., Mahmood, A., & Chopp, M. (2010). Angiogenesis, neurogenesis and brain recovery of function following injury. Current Opinion in Investigational Drugs, 11, 298\u2013308.","journal-title":"Current Opinion in Investigational Drugs"},{"key":"9716_CR33","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1161\/STROKEAHA.113.001943","volume":"44","author":"H Ishikawa","year":"2013","unstructured":"Ishikawa, H., Tajiri, N., Shinozuka, K., et al. (2013). Vasculogenesis in experimental stroke after human cerebral endothelial cell transplantation. Stroke, 44, 3473\u20133481.","journal-title":"Stroke"},{"key":"9716_CR34","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0140-6736(16)31259-4","volume":"388","author":"CV Borlongan","year":"2016","unstructured":"Borlongan, C. V. (2016). Age of PISCES: stem-cell clinical trials in stroke. Lancet, 388, 736\u2013738.","journal-title":"Lancet"},{"key":"9716_CR35","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.expneurol.2005.12.011","volume":"199","author":"K Pollock","year":"2006","unstructured":"Pollock, K., Stroemer, P., Patel, S., et al. (2006). A conditionally immortal clonal stem cell line from human cortical neuroepithelium for the treatment of ischemic stroke. Experimental Neurology, 199, 143\u2013155.","journal-title":"Experimental Neurology"},{"key":"9716_CR36","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/1742-2094-8-133","volume":"8","author":"MA Dao","year":"2011","unstructured":"Dao, M. A., Tate, C. C., Aizman, I., et al. (2011). Comparing the immunosuppressive potency of naive marrow stromal cells and notch-transfected marrow stromal cells. Journal of Neuroinflammation, 8, 133.","journal-title":"Journal of Neuroinflammation"},{"key":"9716_CR37","first-page":"1612","volume":"164","author":"B Sibbald","year":"2001","unstructured":"Sibbald, B. (2001). Death but one unintended consequence of gene-therapy trial. CMAJ, 164, 1612.","journal-title":"CMAJ"},{"key":"9716_CR38","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1089\/scd.2009.0011","volume":"18","author":"T Yasuhara","year":"2009","unstructured":"Yasuhara, T., Matsukawa, N., Hara, K., et al. (2009). Notch-induced rat and human bone marrow stromal cell grafts reduce ischemic cell loss and ameliorate behavioral deficits in chronic stroke animals. Stem Cells and Development, 18, 1501\u20131514.","journal-title":"Stem Cells and Development"},{"key":"9716_CR39","volume":"8","author":"N Tajiri","year":"2013","unstructured":"Tajiri, N., Kaneko, Y., Shinozuka, K., et al. (2013). Stem cell recruitment of newly formed host cells via a successful seduction? Filling the gap between neurogenic niche and injured brain site. PloS One, 8, e74857.","journal-title":"PloS One"},{"key":"9716_CR40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050444","volume":"7","author":"Z Hassani","year":"2012","unstructured":"Hassani, Z., O'Reilly, J., Pearse, Y., et al. (2012). Human neural progenitor cell engraftment increases neurogenesis and microglial recruitment in the brain of rats with stroke. PloS One, 7, e50444.","journal-title":"PloS One"},{"key":"9716_CR41","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1471-2202-10-86","volume":"10","author":"L Stevanato","year":"2009","unstructured":"Stevanato, L., Corteling, R. L., Stroemer, P., et al. (2009). C-MycERTAM transgene silencing in a genetically modified human neural stem cell line implanted into MCAo rodent brain. BMC Neuroscience, 10, 86.","journal-title":"BMC Neuroscience"},{"key":"9716_CR42","doi-asserted-by":"crossref","first-page":"973","DOI":"10.3727\/096368910X494885","volume":"19","author":"CC Tate","year":"2010","unstructured":"Tate, C. C., Fonck, C., McGrogan, M., & Case, C. C. (2010). Human mesenchymal stromal cells and their derivative, SB623 cells, rescue neural cells via trophic support following in vitro ischemia. Cell Transplantation, 19, 973\u2013984.","journal-title":"Cell Transplantation"},{"key":"9716_CR43","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s12975-016-0490-6","volume":"7","author":"E Napoli","year":"2016","unstructured":"Napoli, E., & Borlongan, C. V. (2016). Recent advances in stem cell-based therapeutics for stroke. Transl Stroke Res, 7, 452\u2013457.","journal-title":"Transl Stroke Res"},{"key":"9716_CR44","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s12015-014-9556-6","volume":"11","author":"H Ulrich","year":"2015","unstructured":"Ulrich, H., do Nascimento, I. C., Bocsi, J., & T\u00e1rnok, A. (2015). Immunomodulation in stem cell differentiation into neurons and brain repair. Stem Cell Reviews, 11, 474\u2013486.","journal-title":"Stem Cell Reviews"},{"key":"9716_CR45","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s12015-014-9535-y","volume":"10","author":"HS Kim","year":"2014","unstructured":"Kim, H. S., Choi, S. M., Yang, W., et al. (2014). PSA-NCAM(+) neural precursor cells from human embryonic stem cells promote neural tissue integrity and behavioral performance in a rat stroke model. Stem Cell Reviews, 10, 761\u2013771.","journal-title":"Stem Cell Reviews"}],"container-title":["Stem Cell Reviews and Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-016-9716-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12015-016-9716-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-016-9716-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T03:44:59Z","timestamp":1568691899000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12015-016-9716-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,7]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["9716"],"URL":"https:\/\/doi.org\/10.1007\/s12015-016-9716-y","relation":{},"ISSN":["1550-8943","1558-6804"],"issn-type":[{"type":"print","value":"1550-8943"},{"type":"electronic","value":"1558-6804"}],"subject":[],"published":{"date-parts":[[2017,1,7]]}}}