{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:41:07Z","timestamp":1768002067144,"version":"3.49.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T00:00:00Z","timestamp":1513209600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Rev and Rep"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s12015-017-9797-2","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T16:59:05Z","timestamp":1513270745000},"page":"277-285","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Identification of a Novel High Yielding Source of Multipotent Adult Human Neural Crest-Derived Stem Cells"],"prefix":"10.1007","volume":"14","author":[{"given":"Matthias","family":"Sch\u00fcrmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktoria","family":"Brotzmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlena","family":"B\u00fctow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Greiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"H\u00f6ving","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Kaltschmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Kaltschmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Sudhoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"key":"9797_CR1","doi-asserted-by":"crossref","unstructured":"Wagers, A. J., & Weissman, I. L. Plasticity of adult stem cells. Cell 2004;116:639 \u2013 48.","DOI":"10.1016\/S0092-8674(04)00208-9"},{"key":"9797_CR2","first-page":"7","volume":"4","author":"R Schofield","year":"1978","unstructured":"Schofield, R. (1978). The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells, 4, 7\u201325.","journal-title":"Blood Cells"},{"key":"9797_CR3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.cell.2005.05.010","volume":"122","author":"CA Collins","year":"2005","unstructured":"Collins, C. A., Olsen, I., Zammit, P. S., et al. (2005). Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche. Cell, 122, 289\u2013301.","journal-title":"Cell"},{"key":"9797_CR4","doi-asserted-by":"crossref","unstructured":"Clewes, O., Narytnyk, A., Gillinder, K. R., Loughney, A. D., Murdoch, A. P., & Sieber-Blum, M. Human epidermal neural crest stem cells (hepi-ncsc)-characterization and directed differentiation into osteocytes and melanocytes. Stem Cell Reviews 2011.","DOI":"10.1007\/s12015-011-9255-5"},{"key":"9797_CR5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ydbio.2012.02.035","volume":"366","author":"E Dupin","year":"2012","unstructured":"Dupin, E., & Sommer, L. (2012). Neural crest progenitors and stem cells: from early development to adulthood. Developmental Biology, 366, 83\u201395.","journal-title":"Developmental Biology"},{"key":"9797_CR6","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/dvdy.20360","volume":"233","author":"W Murrell","year":"2005","unstructured":"Murrell, W., Feron, F., Wetzig, A., et al. (2005). Multipotent stem cells from adult olfactory mucosa. Developmental Dynamics, 233, 496\u2013515.","journal-title":"Developmental Dynamics"},{"key":"9797_CR7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5966\/sctm.2014-0078","volume":"4","author":"J M\u00fcller","year":"2015","unstructured":"M\u00fcller, J., Ossig, C., Greiner, J. F., et al. (2015). Intrastriatal transplantation of adult human neural crest-derived stem cells improves functional outcome in Parkinsonian rats. Stem Cells Translational Medicine, 4, 31\u201343.014.","journal-title":"Stem Cells Translational Medicine"},{"key":"9797_CR8","doi-asserted-by":"crossref","DOI":"10.5962\/bhl.title.104964","volume-title":"Untersuchungen \u00fcber die erste Anlage des Wirbeltierleibes. Die erste Entwicklung des H\u00fchnchens im Ei","author":"W His","year":"1868","unstructured":"His, W. (1868). Untersuchungen \u00fcber die erste Anlage des Wirbeltierleibes. Die erste Entwicklung des H\u00fchnchens im Ei. Leipzig: Vogel."},{"key":"9797_CR9","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1007\/s12015-011-9340-9","volume":"8","author":"B Kaltschmidt","year":"2012","unstructured":"Kaltschmidt, B., Kaltschmidt, C., & Widera, D. (2012). Adult craniofacial stem cells: sources and relation to the neural crest. Stem Cell Reviews, 8, 658 \u2013 71.","journal-title":"Stem Cell Reviews"},{"key":"9797_CR10","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/ncb0901-778","volume":"3","author":"JG Toma","year":"2001","unstructured":"Toma, J. G., Akhavan, M., Fernandes, K. J., et al. (2001). Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nature Cell Biology, 3, 778 \u2013 84.","journal-title":"Nature Cell Biology"},{"key":"9797_CR11","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1089\/scd.2011.0419","volume":"21","author":"S Hauser","year":"2012","unstructured":"Hauser, S., Widera, D., Qunneis, F., et al. (2012). Isolation of novel multipotent neural crest-derived stem cells from adult human inferior turbinate. Stem Cells and Development, 21, 742 \u2013 56.","journal-title":"Stem Cells and Development"},{"key":"9797_CR12","doi-asserted-by":"crossref","unstructured":"Tabakow, P., Raisman, G., Fortuna, W., et al. Functional regeneration of supraspinal connections in a patient with transected spinal cord following transplantation of bulbar olfactory ensheathing cells with peripheral nerve bridging. Cell Transplantation 2014.","DOI":"10.3727\/096368914X685131"},{"key":"9797_CR13","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1634\/stemcells.2007-0979","volume":"26","author":"A Arthur","year":"2008","unstructured":"Arthur, A., Rychkov, G., Shi, S., Koblar, S. A., & Gronthos, S. (2008). Adult human dental pulp stem cells differentiate toward functionally active neurons under appropriate environmental cues. Stem Cells, 26, 1787\u20131795.","journal-title":"Stem Cells"},{"key":"9797_CR14","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1001\/archotol.1984.00800360013003","volume":"110","author":"T Nakashima","year":"1984","unstructured":"Nakashima, T., Kimmelman, C. P., & Snow, J. B. Jr. (1984). Structure of human fetal and adult olfactory neuroepithelium. Archives of Otolaryngology, 110, 641\u2013646.","journal-title":"Archives of Otolaryngology"},{"key":"9797_CR15","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1093\/brain\/awh657","volume":"128","author":"F Feron","year":"2005","unstructured":"Feron, F., Perry, C., Cochrane, J., et al. (2005). Autologous olfactory ensheathing cell transplantation in human spinal cord injury. Brain, 128, 2951\u20132960.","journal-title":"Brain"},{"key":"9797_CR16","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1634\/stemcells.2008-0074","volume":"26","author":"W Murrell","year":"2008","unstructured":"Murrell, W., Wetzig, A., Donnellan, M., et al. (2008). Olfactory mucosa is a potential source for autologous stem cell therapy for Parkinson\u2019s disease. Stem Cells, 26, 2183\u20132192.","journal-title":"Stem Cells"},{"key":"9797_CR17","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2302\/kjm.54.8","volume":"54","author":"A Mackay-Sim","year":"2005","unstructured":"Mackay-Sim, A. (2005). Olfactory ensheathing cells and spinal cord repair. The Keio Journal of Medicine, 54, 8\u201314.","journal-title":"The Keio Journal of Medicine"},{"key":"9797_CR18","doi-asserted-by":"crossref","first-page":"403","DOI":"10.22203\/eCM.v022a30","volume":"22","author":"JF Greiner","year":"2011","unstructured":"Greiner, J. F., Hauser, S., Widera, D., et al. (2011). Efficient animal-serum free 3D cultivation method for adult human neural crest-derived stem cell therapeutics. European Cell & Materials, 22, 403 \u2013 19.","journal-title":"European Cell & Materials"},{"key":"9797_CR19","doi-asserted-by":"crossref","first-page":"26716","DOI":"10.1038\/srep26716","volume":"6","author":"AD Hofemeier","year":"2016","unstructured":"Hofemeier, A. D., Hachmeister, H., Pilger, C., et al. (2016). Label-free nonlinear optical microscopy detects early markers for osteogenic differentiation of human stem cells. Scientific Reports, 6, 26716.","journal-title":"Scientific Reports"},{"key":"9797_CR20","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1042\/CS20160218","volume":"130","author":"J Muller","year":"2016","unstructured":"Muller, J., Greiner, J. F., Zeuner, M., et al. (2016). 1,8-Cineole potentiates IRF3-mediated antiviral response in human stem cells and in an ex vivo model of rhinosinusitis. Clinical Science (London), 130, 1339\u20131352.","journal-title":"Clinical Science (London)"},{"key":"9797_CR21","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1089\/scd.2009.0267","volume":"19","author":"B Delorme","year":"2010","unstructured":"Delorme, B., Nivet, E., Gaillard, J., et al. (2010). The human nose harbors a niche of olfactory ectomesenchymal stem cells displaying neurogenic and osteogenic properties. Stem Cells and Development, 19, 853 \u2013 66.","journal-title":"Stem Cells and Development"},{"key":"9797_CR22","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/chemse\/27.9.831","volume":"27","author":"M Damm","year":"2002","unstructured":"Damm, M., Vent, J., Schmidt, M., et al. (2002). Intranasal volume and olfactory function. Chemical Senses, 27, 831\u2013839.","journal-title":"Chemical Senses"},{"issue":"Pt 8","key":"9797_CR23","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1093\/brain\/123.8.1581","volume":"123","author":"SC Barnett","year":"2000","unstructured":"Barnett, S. C., Alexander, C. L., Iwashita, Y., et al. (2000). Identification of a human olfactory ensheathing cell that can effect transplant-mediated remyelination of demyelinated CNS axons. Brain, 123(Pt 8), 1581\u20131588.","journal-title":"Brain"},{"key":"9797_CR24","doi-asserted-by":"crossref","first-page":"21040","DOI":"10.1073\/pnas.1012248107","volume":"107","author":"P Barraud","year":"2010","unstructured":"Barraud, P., Seferiadis, A. A., Tyson, L. D., et al. (2010)Neural crest origin of olfactory ensheathing glia. Proceedings of the National Academy of Sciences of the United States of America ;107:21040\u20135.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"9797_CR25","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s10517-007-0385-3","volume":"144","author":"IV Viktorov","year":"2007","unstructured":"Viktorov, I. V., Savchenko, E. A., & Chekhonin, V. P. (2007). Spontaneous neural differentiation of stem cells in culture of human olfactory epithelium. Bulletin of Experimental Biology and Medicine, 144, 596\u2013601.","journal-title":"Bulletin of Experimental Biology and Medicine"},{"key":"9797_CR26","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/cne.21385","volume":"503","author":"A Jahed","year":"2007","unstructured":"Jahed, A., Rowland, J. W., McDonald, T., Boyd, J. G., Doucette, R., & Kawaja, M. D. (2007). Olfactory ensheathing cells express smooth muscle alpha-actin in vitro and in vivo. The Journal of Comparative Neurology, 503, 209 \u2013 23.","journal-title":"The Journal of Comparative Neurology"},{"key":"9797_CR27","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1172\/JCI44489","volume":"121","author":"E Nivet","year":"2011","unstructured":"Nivet, E., Vignes, M., Girard, S. D., et al. (2011). Engraftment of human nasal olfactory stem cells restores neuroplasticity in mice with hippocampal lesions. The Journal of Clinical Investigation, 121, 2808\u20132820.","journal-title":"The Journal of Clinical Investigation"},{"key":"9797_CR28","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1177\/0194599816644915","volume":"155","author":"A Dayal","year":"2016","unstructured":"Dayal, A., Rhee, J. S., & Garcia, G. J. (2016). Impact of middle versus inferior total turbinectomy on nasal aerodynamics. Otolaryngology\u2013Head and Neck Surgery: Official Journal of American Academy of Otolaryngology-Head and. Neck Surgery, 155, 518 \u2013 25.","journal-title":"Otolaryngology\u2013Head and Neck Surgery: Official Journal of American Academy of Otolaryngology-Head and. Neck Surgery"},{"key":"9797_CR29","first-page":"Doc03","volume":"9","author":"MO Scheithauer","year":"2010","unstructured":"Scheithauer, M. O. (2010). Surgery of the turbinates and \u201cempty nose\u201d syndrome. GMS Current Topics Otorhinolaryngol Head Neck Surgery, 9, Doc03.","journal-title":"GMS Current Topics Otorhinolaryngol Head Neck Surgery"},{"key":"9797_CR30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ejcts.2005.02.045","volume":"28","author":"P Modi","year":"2005","unstructured":"Modi, P., & Rahamim, J. (2005). Fibrin sealant treatment of splenic injuries during oesophagectomy. European Journal Cardiothoracic Surgery, 28, 167\u2013168.","journal-title":"European Journal Cardiothoracic Surgery"},{"key":"9797_CR31","doi-asserted-by":"crossref","unstructured":"Dahlstrom, K. K., Weis-Fogh, U. S., Medgyesi, S., Rostgaard, J., & Sorensen, H. The use of autologous fibrin adhesive in skin transplantation. Plastic and Reconstructive Surgery 1992;89:968 \u2013 72; discussion 73 \u2013 6.","DOI":"10.1097\/00006534-199205000-00034"},{"issue":"1","key":"9797_CR32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3727\/096368911X576018","volume":"21","author":"C Gerard","year":"2012","unstructured":"Gerard, C., Forest, M. A., Beauregard, G., Skuk, D., & Tremblay, J. P. (2012). Fibrin gel improves the survival of transplanted myoblasts. Cell Transplantation, 21(1), 127 \u2013 37.","journal-title":"Cell Transplantation"},{"key":"9797_CR33","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1089\/ten.2006.12.1587","volume":"12","author":"W Ho","year":"2006","unstructured":"Ho, W., Tawil, B., Dunn, J. C., & Wu, B. M. (2006). The behavior of human mesenchymal stem cells in 3D fibrin clots: dependence on fibrinogen concentration and clot structure. Tissue Engineering, 12, 1587\u20131595.","journal-title":"Tissue Engineering"},{"key":"9797_CR34","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/term.446","volume":"6","author":"A Peterbauer-Scherb","year":"2012","unstructured":"Peterbauer-Scherb, A., Danzer, M., Gabriel, C., van Griensven, M., Redl, H., & Wolbank, S. (2012). In vitro adipogenesis of adipose-derived stem cells in 3D fibrin matrix of low component concentration. Journal Tissue of Engineering and Regenerative Medicine, 6, 434 \u2013 42.","journal-title":"Journal Tissue of Engineering and Regenerative Medicine"},{"key":"9797_CR35","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/scrt422","volume":"5","author":"JF Greiner","year":"2014","unstructured":"Greiner, J. F., Grunwald, L. M., Muller, J., et al. (2014). Culture bag systems for clinical applications of adult human neural crest-derived stem cells. Stem Cell Research & Therapy, 5, 34.","journal-title":"Stem Cell Research & Therapy"}],"container-title":["Stem Cell Reviews and Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12015-017-9797-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-017-9797-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-017-9797-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T21:35:07Z","timestamp":1570484107000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12015-017-9797-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,14]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["9797"],"URL":"https:\/\/doi.org\/10.1007\/s12015-017-9797-2","relation":{},"ISSN":["1550-8943","1558-6804"],"issn-type":[{"value":"1550-8943","type":"print"},{"value":"1558-6804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,14]]}}}