{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:00:46Z","timestamp":1793059246620,"version":"4.5.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Rev and Rep"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s12015-020-10039-0","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T17:03:09Z","timestamp":1600102989000},"page":"1173-1184","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Human Female Reproductive System Organoids: Applications in Developmental Biology, Disease Modelling, and Drug Discovery"],"prefix":"10.1007","volume":"16","author":[{"given":"Yutong","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanqiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suwen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5929-5101","authenticated-orcid":false,"given":"Xiaotian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,14]]},"reference":[{"key":"10039_CR1","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41576-018-0051-9","volume":"19","author":"R Giuliana","year":"2018","unstructured":"Giuliana, R., Andrea, M., & Lutolf, M. P. (2018). Progress and potential in organoid research. Nature Reviews Genetics, 19, 671\u2013687.","journal-title":"Nature Reviews Genetics"},{"key":"10039_CR2","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.devcel.2016.08.014","volume":"38","author":"K Kai","year":"2016","unstructured":"Kai, K., & Hans, C. (2016). Organoids: Modeling development and the stem cell niche in a dish. Developmental Cell, 38, 590\u2013600.","journal-title":"Developmental Cell"},{"key":"10039_CR3","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/ncb3516","volume":"19","author":"MY Turco","year":"2017","unstructured":"Turco, M. Y., Lucy, G., Jasmine, H., et al. (2017). Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium. Nature Cell Biology, 19, 568\u2013577.","journal-title":"Nature Cell Biology"},{"key":"10039_CR4","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.stemcr.2018.07.004","volume":"11","author":"H Sandra","year":"2018","unstructured":"Sandra, H., Gudrun, M., Leila, S., et al. (2018). Self-renewing trophoblast organoids recapitulate the developmental program of the early human placenta. Stem Cell Reports, 11, 537\u2013551.","journal-title":"Stem Cell Reports"},{"key":"10039_CR5","doi-asserted-by":"crossref","first-page":"1247125","DOI":"10.1126\/science.1247125","volume":"345","author":"MA Lancaster","year":"2014","unstructured":"Lancaster, M. A., & Knoblich, J. A. (2014). Organogenesis in a dish: Modeling development and disease using organoid technologies. Science, 345, 1247125.","journal-title":"Science"},{"key":"10039_CR6","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","volume":"131","author":"T Kazutoshi","year":"2007","unstructured":"Kazutoshi, T., Koji, T., Mari, O., et al. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 131, 861\u2013872.","journal-title":"Cell"},{"key":"10039_CR7","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.cell.2008.07.041","volume":"134","author":"P In-Hyun","year":"2008","unstructured":"In-Hyun, P., Natasha, A., Hongguang, H., et al. (2008). Disease-specific induced pluripotent stem cells. Cell, 134, 877\u2013886.","journal-title":"Cell"},{"key":"10039_CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.pmbts.2018.07.009","volume":"160","author":"G Narasimman","year":"2018","unstructured":"Narasimman, G., Abdulrhman, A., Sheeja, R., et al. (2018). Adult stem cells for regenerative therapy. Progress in Molecular Biology and Translational Science, 160, 1\u201322.","journal-title":"Progress in Molecular Biology and Translational Science"},{"key":"10039_CR9","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3389\/fcell.2020.00084","volume":"8","author":"H Youssef","year":"2020","unstructured":"Youssef, H., & Anis, F. (2020). Organoid models of human endometrial development and disease. Frontiers in Cell and Developmental Biology, 8, 84.","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"10039_CR10","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","volume":"282","author":"JA Thomson","year":"1998","unstructured":"Thomson, J. A., Itskovitz-Eldor, J., Shapiro, S., et al. (1998). Embryonic stem cell lines derived from human blastocysts. Science, 282, 1145\u20131147.","journal-title":"Science"},{"key":"10039_CR11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature09941","volume":"472","author":"E Mototsugu","year":"2011","unstructured":"Mototsugu, E., Nozomu, T., Hiroki, I., et al. (2011). Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature, 472, 51\u201356.","journal-title":"Nature"},{"key":"10039_CR12","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature07935","volume":"459","author":"S Toshiro","year":"2009","unstructured":"Toshiro, S., Vries, R. G., Snippert, H. J., et al. (2009). Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature, 459, 262\u2013265.","journal-title":"Nature"},{"key":"10039_CR13","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/BF02620878","volume":"24","author":"CA Rinehart","year":"1988","unstructured":"Rinehart, C. A., Lyn-Cook, B. D., & Kaufman, D. G. (1988). Gland formation from human endometrial epithelial cells in vitro. In Vitro Cellular & Developmental Biology, 24, 1037\u20131041.","journal-title":"In Vitro Cellular & Developmental Biology"},{"key":"10039_CR14","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1093\/humrep\/deh722","volume":"20","author":"M Bl\u00e4uer","year":"2005","unstructured":"Bl\u00e4uer, M., Heinonen, P. K., Martikainen, P. M., Tom\u00e1s, E., & Ylikomi, T. (2005). A novel organotypic culture model for normal human endometrium: Regulation of epithelial cell proliferation by estradiol and medroxyprogesterone acetate. Human Reproduction, 20, 864\u2013871.","journal-title":"Human Reproduction"},{"key":"10039_CR15","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1093\/humrep\/dex289","volume":"32","author":"HPT Nguyen","year":"2017","unstructured":"Nguyen, H. P. T., Xiao, L., Deane, J. A., et al. (2017). N-cadherin identifies human endometrial epithelial progenitor cells by in vitro stem cell assays. Human Reproduction, 32, 2254\u20132268.","journal-title":"Human Reproduction"},{"key":"10039_CR16","doi-asserted-by":"crossref","first-page":"23132","DOI":"10.1073\/pnas.1915389116","volume":"116","author":"HC Fitzgerald","year":"2019","unstructured":"Fitzgerald, H. C., Dhakal, P., Behura, S. K., et al. (2019). Self-renewing endometrial epithelial organoids of the human uterus. Proceedings of the National Academy of Sciences of the United States of America, 116, 23132\u201323142.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10039_CR17","first-page":"2816","volume":"30","author":"AJ Valentijn","year":"2015","unstructured":"Valentijn, A. J., Saretzki, G., Tempest, N., Critchley, H. O., & Hapangama, D. K. (2015). Human endometrial epithelial telomerase is important for epithelial proliferation and glandular formation with potential implications in endometriosis. Human Reproduction, 30, 2816\u20132828.","journal-title":"Human Reproduction"},{"key":"10039_CR18","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.stem.2019.11.012","volume":"26","author":"SM Syed","year":"2020","unstructured":"Syed, S. M., Kumar, M., Ghosh, A., et al. (2020). Endometrial axin2 cells drive epithelial homeostasis, regeneration, and cancer following oncogenic transformation. Cell Stem Cell, 26, 64\u201380.e13.","journal-title":"Cell Stem Cell"},{"key":"10039_CR19","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1210\/en.2019-00314","volume":"160","author":"H Sandra","year":"2019","unstructured":"Sandra, H., Magdalena, G., Burkard, T. R., et al. (2019). Estrogen signaling drives ciliogenesis in human endometrial organoids. Endocrinology, 160, 2282\u20132297.","journal-title":"Endocrinology"},{"key":"10039_CR20","doi-asserted-by":"publisher","unstructured":"Murphy, A. R., Teerawat, W., Lu, Z., et al. (2019). Generation of multicellular human primary endometrial organoids. Journal of Visualized Experiments, 152. https:\/\/doi.org\/10.3791\/60384.","DOI":"10.3791\/60384"},{"key":"10039_CR21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3109\/07357907.2013.877479","volume":"32","author":"EA Bishop","year":"2014","unstructured":"Bishop, E. A., Stan, L., Elangovan, T., et al. (2014). Insulin exerts direct effects on carcinogenic transformation of human endometrial organotypic cultures. Cancer Investigation, 32, 63\u201370.","journal-title":"Cancer Investigation"},{"key":"10039_CR22","volume":"85","author":"\u0141 Pawe\u0142","year":"2017","unstructured":"Pawe\u0142, \u0141., Gomez, A., Hire, G., et al. (2017). Human three-dimensional endometrial epithelial cell model to study host interactions with vaginal bacteria and Neisseria gonorrhoeae. Infection and Immunity, 85, e01049-16.","journal-title":"Infection and Immunity"},{"key":"10039_CR23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4137\/GRSB.S344","volume":"2","author":"DM Benbrook","year":"2008","unstructured":"Benbrook, D. M., Stan, L., James, R.-M., et al. (2008). Gene expression analysis of biological systems driving an organotypic model of endometrial carcinogenesis and chemoprevention. Gene Regulation and Systems Biology, 2, 21\u201342.","journal-title":"Gene Regulation and Systems Biology"},{"key":"10039_CR24","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S0015-0282(02)03302-2","volume":"78","author":"S Kamelle","year":"2002","unstructured":"Kamelle, S., Sienko, A., & Benbrook, D. M. (2002). Retinoids and steroids regulate menstrual phase histological features in human endometrial organotypic cultures. Fertility and Sterility, 78, 596\u2013602.","journal-title":"Fertility and Sterility"},{"key":"10039_CR25","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.rbmo.2017.05.020","volume":"35","author":"M Fayazi","year":"2017","unstructured":"Fayazi, M., Salehnia, M., & Ziaei, S. (2017). In-vitro construction of endometrial-like epithelium using CD146 mesenchymal cells derived from human endometrium. Reproductive Biomedicine Online, 35, 241\u2013252.","journal-title":"Reproductive Biomedicine Online"},{"key":"10039_CR26","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.rbmo.2017.07.009","volume":"35","author":"MH Johnson","year":"2017","unstructured":"Johnson, M. H. (2017). First evidence that endometrial-like organoids can develop from the endometrial mesenchymal stem\/stromal cell population. Reproductive Biomedicine Online, 35, 239\u2013240.","journal-title":"Reproductive Biomedicine Online"},{"key":"10039_CR27","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1210\/clinem\/dgz100","volume":"105","author":"T Wiwatpanit","year":"2020","unstructured":"Wiwatpanit, T., Murphy, A. R., Lu, Z., et al. (2020). Scaffold-free endometrial organoids respond to excess androgens associated with polycystic ovarian syndrome. The Journal of Clinical Endocrinology and Metabolism, 105, 769\u2013780.","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10039_CR28","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/s41556-019-0360-z","volume":"21","author":"M Boretto","year":"2019","unstructured":"Boretto, M., Maenhoudt, N., Luo, X., et al. (2019). Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening. Nature Cell Biology, 21, 1041\u20131051.","journal-title":"Nature Cell Biology"},{"key":"10039_CR29","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s004410050743","volume":"287","author":"I Classen-Linke","year":"1997","unstructured":"Classen-Linke, I., Kusche, M., Knauthe, R., & Beier, H. M. (1997). Establishment of a human endometrial cell culture system and characterization of its polarized hormone responsive epithelial cells. Cell and Tissue Research, 287, 171\u2013185.","journal-title":"Cell and Tissue Research"},{"key":"10039_CR30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/emm.2002.11","volume":"34","author":"H Yang","year":"2002","unstructured":"Yang, H., Sungwon, H., Haekwon, K., et al. (2002). Expression of integrins, cyclooxygenases and matrix metalloproteinases in three-dimensional human endometrial cell culture system. Experimental & Molecular Medicine, 34, 75\u201382.","journal-title":"Experimental & Molecular Medicine"},{"key":"10039_CR31","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1038\/s41598-018-38376-8","volume":"9","author":"H Aur\u00e9lie","year":"2019","unstructured":"Aur\u00e9lie, H., Katharina, H., Matteo, B., et al. (2019). Functional expression of the mechanosensitive PIEZO1 channel in primary endometrial epithelial cells and endometrial organoids. Scientific Reports, 9, 1779.","journal-title":"Scientific Reports"},{"key":"10039_CR32","first-page":"1","volume-title":"Characterization of human endometrial glandular epithelium in vitro and in vivo","author":"FSV Barros","year":"2017","unstructured":"Barros, F. S. V. (2017). Characterization of human endometrial glandular epithelium in vitro and in vivo (pp. 1\u2013252). Warwick: Division of Biomedical Sciences Warwick Medical School University of Warwick."},{"key":"10039_CR33","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1242\/dev.148478","volume":"144","author":"M Boretto","year":"2017","unstructured":"Boretto, M., Cox, B., Noben, M., et al. (2017). Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability. Development, 144, 1775\u20131786.","journal-title":"Development"},{"key":"10039_CR34","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/humrep\/dey336","volume":"34","author":"DK Hapangama","year":"2019","unstructured":"Hapangama, D. K., Drury, J., Da Silva, L., et al. (2019). Abnormally located SSEA1+\/SOX9+ endometrial epithelial cells with a basalis-like phenotype in the eutopic functionalis layer may play a role in the pathogenesis of endometriosis. Human Reproduction, 34, 56\u201368.","journal-title":"Human Reproduction"},{"key":"10039_CR35","first-page":"347","volume":"2019","author":"P \u0141aniewski","year":"1997","unstructured":"\u0141aniewski, P., & Herbst-Kralovetz, M. M. (1997). Analysis of host responses to Neisseria gonorrhoeae using a human three-dimensional endometrial epithelial cell model. Methods in Molecular Biology, 2019, 347\u2013361.","journal-title":"Methods in Molecular Biology"},{"key":"10039_CR36","doi-asserted-by":"crossref","DOI":"10.1098\/rsfs.2019.0016","volume":"9","author":"SG Zambuto","year":"2019","unstructured":"Zambuto, S. G., Clancy, K. B. H., & Harley, B. A. C. (2019). A gelatin hydrogel to study endometrial angiogenesis and trophoblast invasion. Interface Focus, 9, 20190016.","journal-title":"Interface Focus"},{"key":"10039_CR37","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.stemcr.2018.10.002","volume":"11","author":"K Miyazaki","year":"2018","unstructured":"Miyazaki, K., Dyson, M. T., Coon, V., John, S., et al. (2018). Generation of progesterone-responsive endometrial stromal fibroblasts from human induced pluripotent stem cells: Role of the WNT\/CTNNB1 pathway. Stem Cell Reports, 11, 1136\u20131155.","journal-title":"Stem Cell Reports"},{"key":"10039_CR38","doi-asserted-by":"crossref","first-page":"8989","DOI":"10.1038\/ncomms9989","volume":"6","author":"M Kessler","year":"2015","unstructured":"Kessler, M., Hoffmann, K., Brinkmann, V., et al. (2015). The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids. Nature Communications, 6, 8989.","journal-title":"Nature Communications"},{"key":"10039_CR39","doi-asserted-by":"crossref","first-page":"10741","DOI":"10.1038\/s41598-017-05519-2","volume":"7","author":"N Yucer","year":"2017","unstructured":"Yucer, N., Holzapfel, M., Vogel, T. J., et al. (2017). Directed differentiation of human induced pluripotent stem cells into fallopian tube epithelium. Scientific Reports, 7, 10741.","journal-title":"Scientific Reports"},{"key":"10039_CR40","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2121-14-43","volume":"14","author":"K Lawrenson","year":"2013","unstructured":"Lawrenson, K., Notaridou, M., Lee, N., et al. (2013). In vitro three-dimensional modeling of fallopian tube secretory epithelial cells. BMC Cell Biology, 14, 43.","journal-title":"BMC Cell Biology"},{"key":"10039_CR41","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/s41467-019-09144-7","volume":"10","author":"M Kessler","year":"2019","unstructured":"Kessler, M., Hoffmann, K., Fritsche, K., et al. (2019). Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation. Nature Communications, 10, 1194.","journal-title":"Nature Communications"},{"key":"10039_CR42","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12929-019-0602-1","volume":"27","author":"C Yu-Hsun","year":"2020","unstructured":"Yu-Hsun, C., Tang-Yuan, C., & Dah-Ching, D. (2020). Human fallopian tube epithelial cells exhibit stemness features, self-renewal capacity, and Wnt-related organoid formation. Journal of Biomedical Science, 27, 32.","journal-title":"Journal of Biomedical Science"},{"key":"10039_CR43","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41586-018-0753-3","volume":"564","author":"MY Turco","year":"2018","unstructured":"Turco, M. Y., Gardner, L., Kay, R. G., et al. (2018). Trophoblast organoids as a model for maternal-fetal interactions during human placentation. Nature, 564, 263\u2013267.","journal-title":"Nature"},{"key":"10039_CR44","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.bbrc.2018.09.181","volume":"505","author":"Z Li","year":"2018","unstructured":"Li, Z., Kurosawa, O., & Iwata, H. (2018). Development of trophoblast cystic structures from human induced pluripotent stem cells in limited-area cell culture. Biochemical and Biophysical Research Communications, 505, 671\u2013676.","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10039_CR45","doi-asserted-by":"crossref","first-page":"15680","DOI":"10.1038\/ncomms15680","volume":"8","author":"J Dajung","year":"2017","unstructured":"Dajung, J., Xiong, J., Min, Y., et al. (2017). In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells. Nature Communications, 8, 15680.","journal-title":"Nature Communications"},{"key":"10039_CR46","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1365-2184.2009.00604.x","volume":"42","author":"K Lawrenson","year":"2009","unstructured":"Lawrenson, K., Benjamin, E., Turmaine, M., Jacobs, I., Gayther, S., & Dafou, D. (2009). In vitro three-dimensional modelling of human ovarian surface epithelial cells. Cell Proliferation, 42, 385\u2013393.","journal-title":"Cell Proliferation"},{"key":"10039_CR47","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0015-0282(98)00415-4","volume":"71","author":"H Ohtake","year":"1999","unstructured":"Ohtake, H., Katabuchi, H., Matsuura, K., et al. (1999). A novel in vitro experimental model for ovarian endometriosis: The three-dimensional culture of human ovarian surface epithelial cells in collagen gels. Fertility and Sterility, 71, 50\u201355.","journal-title":"Fertility and Sterility"},{"key":"10039_CR48","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1097\/IGC.0000000000001061","volume":"27","author":"E Girda","year":"2017","unstructured":"Girda, E., Huang, E. C., Leiserowitz, G. S., et al. (2017). The use of endometrial cancer patient-derived organoid culture for drug sensitivity testing is feasible. The International Journal of Gynecological Cancer, 27, 1701\u20131707.","journal-title":"The International Journal of Gynecological Cancer"},{"key":"10039_CR49","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.1038\/s41467-019-13116-2","volume":"10","author":"Z Shuang","year":"2019","unstructured":"Shuang, Z., Igor, D., Tao, Z., et al. (2019). Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma. Nature Communications, 10, 5367.","journal-title":"Nature Communications"},{"key":"10039_CR50","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1002\/stem.1207","volume":"30","author":"DY Paik","year":"2012","unstructured":"Paik, D. Y., Janzen, D. M., Schafenacker, A. M., et al. (2012). Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: A site for injury and serous cancer initiation. Stem Cells, 30, 2487\u20132497.","journal-title":"Stem Cells"},{"key":"10039_CR51","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2017.0131","volume":"14","author":"Y Abbas","year":"2017","unstructured":"Abbas, Y., Oefner, C. M., Polacheck, W. J., et al. (2017). A microfluidics assay to study invasion of human placental trophoblast cells. The Journal of the Royal Society Interface, 14, 20170131.","journal-title":"The Journal of the Royal Society Interface"},{"key":"10039_CR52","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/icb.2017.45","volume":"95","author":"L Ma","year":"2017","unstructured":"Ma, L., Li, G., Cao, G., et al. (2017). dNK cells facilitate the interaction between trophoblastic and endothelial cells via VEGF-C and HGF. Immunology and Cell Biology, 95, 695\u2013704.","journal-title":"Immunology and Cell Biology"},{"key":"10039_CR53","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1501462","volume":"2","author":"CA McConkey","year":"2016","unstructured":"McConkey, C. A., Delorme-Axford, E., Nickerson, C. A., et al. (2016). A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance. Science Advances, 2, e1501462.","journal-title":"Science Advances"},{"key":"10039_CR54","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.3390\/ijms19082322","volume":"19","author":"S Kotomi","year":"2018","unstructured":"Kotomi, S., Yasuhisa, M., Michiya, S., et al. (2018). Aggregation of human trophoblast cells into three-dimensional culture system enhances anti-inflammatory characteristics through cytoskeleton regulation. The International Journal of Molecular Sciences, 19, 2322.","journal-title":"The International Journal of Molecular Sciences"},{"key":"10039_CR55","volume":"13","author":"MK Wong","year":"2018","unstructured":"Wong, M. K., Shawky, S. A., Aryasomayajula, A., et al. (2018). Extracellular matrix surface regulates self-assembly of three-dimensional placental trophoblast spheroids. PLoS One, 13, e199632.","journal-title":"PLoS One"},{"key":"10039_CR56","doi-asserted-by":"crossref","first-page":"39885","DOI":"10.1038\/srep39885","volume":"7","author":"S Kalkunte","year":"2017","unstructured":"Kalkunte, S., Huang, Z., Lippe, E., et al. (2017). Polychlorinated biphenyls target Notch\/Dll and VEGF R2 in the mouse placenta and human trophoblast cell lines for their anti-angiogenic effects. Scientific Reports, 7, 39885.","journal-title":"Scientific Reports"},{"key":"10039_CR57","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s42003-019-0305-x","volume":"2","author":"P Nhan","year":"2019","unstructured":"Nhan, P., Hong, J. J., Tofig, B., et al. (2019). A simple high-throughput approach identifies actionable drug sensitivities in patient-derived tumor organoids. Communications Biology, 2, 78.","journal-title":"Communications Biology"},{"key":"10039_CR58","doi-asserted-by":"crossref","first-page":"955","DOI":"10.15252\/msb.20177697","volume":"13","author":"J Jabs","year":"2017","unstructured":"Jabs, J., Zickgraf, F. M., Park, J., et al. (2017). Screening drug effects in patient-derived cancer cells links organoid responses to genome alterations. Molecular Systems Biology, 13, 955.","journal-title":"Molecular Systems Biology"},{"key":"10039_CR59","first-page":"93","volume":"2018","author":"CA Moore","year":"1842","unstructured":"Moore, C. A., Shah, N. N., Smith, C. P., et al. (1842). 3D bioprinting and stem cells. Methods in Molecular Biology, 2018, 93\u2013103.","journal-title":"Methods in Molecular Biology"},{"key":"10039_CR60","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.biomaterials.2016.09.003","volume":"110","author":"YS Zhang","year":"2016","unstructured":"Zhang, Y. S., Arneri, A., Bersini, S., et al. (2016). Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip. Biomaterials, 110, 45\u201359.","journal-title":"Biomaterials"},{"key":"10039_CR61","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s13045-019-0832-4","volume":"12","author":"F Han","year":"2019","unstructured":"Han, F., Utkan, D., & Pu, C. (2019). Emerging organoid models: leaping forward in cancer research. Journal of Hematology & Oncology, 12, 142.","journal-title":"Journal of Hematology & Oncology"},{"key":"10039_CR62","doi-asserted-by":"crossref","first-page":"8352","DOI":"10.1002\/jcp.27729","volume":"234","author":"R Mittal","year":"2019","unstructured":"Mittal, R., Woo, F. W., Castro, C. S., et al. (2019). Organ-on-chip models: Implications in drug discovery and clinical applications. Journal of Cellular Physiology, 234, 8352\u20138380.","journal-title":"Journal of Cellular Physiology"}],"container-title":["Stem Cell Reviews and Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-020-10039-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12015-020-10039-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-020-10039-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T20:05:41Z","timestamp":1723579541000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12015-020-10039-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,14]]},"references-count":62,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10039"],"URL":"https:\/\/doi.org\/10.1007\/s12015-020-10039-0","relation":{},"ISSN":["2629-3269","2629-3277"],"issn-type":[{"value":"2629-3269","type":"print"},{"value":"2629-3277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,14]]},"assertion":[{"value":"7 September 2020","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2020","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest Disclosures"}}]}}