{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:56:21Z","timestamp":1786982181390,"version":"build-2736575974"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"publisher","award":["R21AA025723"],"award-info":[{"award-number":["R21AA025723"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"publisher","award":["R01HL136345"],"award-info":[{"award-number":["R01HL136345"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"publisher","award":["R01AA028527"],"award-info":[{"award-number":["R01AA028527"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"publisher","award":["UL1-TR002378"],"award-info":[{"award-number":["UL1-TR002378"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"national science foundation","doi-asserted-by":"publisher","award":["CBET 1926387"],"award-info":[{"award-number":["CBET 1926387"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Rev and Rep"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s12015-021-10267-y","type":"journal-article","created":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T17:02:36Z","timestamp":1632589356000},"page":"2314-2331","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Chronic Ethanol Exposure Induces Deleterious Changes in Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells"],"prefix":"10.1007","volume":"17","author":[{"given":"Rui","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangxu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence C.","family":"Armand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1748-0648","authenticated-orcid":false,"given":"Chunhui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,25]]},"reference":[{"key":"10267_CR1","doi-asserted-by":"crossref","unstructured":"Degenhardt, L., Chiu, W. T., Sampson, N., Kessler, R. C., Anthony, J. C., Angermeyer, M., Bruffaerts, R., de Girolamo, G., Gureje, O., Huang, Y., et al. (2008) Toward a global view of alcohol, tobacco, cannabis, and cocaine use: Findings from the WHO world mental health surveys. PLoS Med, 5(7), e141.","DOI":"10.1371\/journal.pmed.0050141"},{"key":"10267_CR2","unstructured":"World Health Organization. Global status report on alcohol and health. Available at: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/274603\/9789241565639-eng.pdf?ua=1 (Accessed 27 Feb 2021)."},{"issue":"2","key":"10267_CR3","doi-asserted-by":"publisher","first-page":"572","DOI":"10.3390\/nu12020572","volume":"12","author":"J Fernandez-Sola","year":"2020","unstructured":"Fernandez-Sola, J. (2020). The effects of ethanol on the heart: Alcoholic cardiomyopathy. Nutrients, 12(2), 572.","journal-title":"Nutrients"},{"key":"10267_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.drugalcdep.2015.08.023","volume":"156","author":"A Erol","year":"2015","unstructured":"Erol, A., & Karpyak, V. M. (2015). Sex and gender-related differences in alcohol use and its consequences: Contemporary knowledge and future research considerations. Drug and Alcohol Dependence, 156, 1\u201313.","journal-title":"Drug and Alcohol Dependence"},{"issue":"4","key":"10267_CR5","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1093\/alcalc\/agz050","volume":"54","author":"MF Mogos","year":"2019","unstructured":"Mogos, M. F., Salemi, J. L., Phillips, S. A., & Piano, M. R. (2019). Contemporary appraisal of sex differences in prevalence, correlates, and outcomes of alcoholic cardiomyopathy. Alcohol and Alcoholism, 54(4), 386\u2013395.","journal-title":"Alcohol and Alcoholism"},{"issue":"2","key":"10267_CR6","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1001\/jama.1995.03530020067034","volume":"274","author":"A Urbano-Marquez","year":"1995","unstructured":"Urbano-Marquez, A., Estruch, R., Fernandez-Sola, J., Nicolas, J. M., Pare, J. C., & Rubin, E. (1995). The greater risk of alcoholic cardiomyopathy and myopathy in women compared with men. JAMA, 274(2), 149\u2013154.","journal-title":"JAMA"},{"key":"10267_CR7","unstructured":"Centers for Disease Control and Prevention. Excessive alcohol use is a risk to women's health. Available at: https:\/\/www.cdc.gov\/alcohol\/fact-sheets\/womens-health.htm (Accessed 27 Feb 2021)."},{"key":"10267_CR8","unstructured":"Centers for Disease Control and Prevention. Fetal alcohol spectrum disorders. Available at: https:\/\/www.cdc.gov\/ncbddd\/fasd\/data.html (Accessed 1 Mar 2021)."},{"issue":"4","key":"10267_CR9","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1111\/j.1747-0803.2007.00105.x","volume":"2","author":"L Burd","year":"2007","unstructured":"Burd, L., Deal, E., Rios, R., Adickes, E., Wynne, J., & Klug, M. G. (2007). Congenital heart defects and fetal alcohol spectrum disorders. Congenital Heart Disease, 2(4), 250\u2013255.","journal-title":"Congenital Heart Disease"},{"issue":"7","key":"10267_CR10","doi-asserted-by":"publisher","first-page":"E740","DOI":"10.1152\/ajpendo.00465.2013","volume":"306","author":"MM El-Mas","year":"2014","unstructured":"El-Mas, M. M., & Abdel-Rahman, A. A. (2014). Nongenomic effects of estrogen mediate the dose-related myocardial oxidative stress and dysfunction caused by acute ethanol in female rats. American journal of physiology. Endocrinology and metabolism, 306(7), E740-747.","journal-title":"American journal of physiology. Endocrinology and metabolism"},{"issue":"2","key":"10267_CR11","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1002\/jcp.25934","volume":"233","author":"Z Zhu","year":"2018","unstructured":"Zhu, Z., Huang, Y., Lv, L., Tao, Y., Shao, M., Zhao, C., Xue, M., Sun, J., Niu, C., Wang, Y., et al. (2018). Acute ethanol exposure-induced autophagy-mediated cardiac injury via activation of the ROS-JNK-Bcl-2 pathway. Journal of Cellular Physiology, 233(2), 924\u2013935.","journal-title":"Journal of Cellular Physiology"},{"key":"10267_CR12","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.yjmcc.2018.02.002","volume":"116","author":"J Mustroph","year":"2018","unstructured":"Mustroph, J., Wagemann, O., Lebek, S., Tarnowski, D., Ackermann, J., Drzymalski, M., Pabel, S., Schmid, C., Wagner, S., Sossalla, S., et al. (2018). SR Ca(2+)-leak and disordered excitation-contraction coupling as the basis for arrhythmogenic and negative inotropic effects of acute ethanol exposure. Journal of Molecular and Cellular Cardiology, 116, 81\u201390.","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"1","key":"10267_CR13","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1093\/toxsci\/kfz038","volume":"169","author":"A Rampoldi","year":"2019","unstructured":"Rampoldi, A., Singh, M., Wu, Q., Duan, M., Jha, R., Maxwell, J. T., Bradner, J. M., Zhang, X., Saraf, A., Miller, G. W., et al. (2019). Cardiac toxicity from ethanol exposure in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicological Sciences, 169(1), 280\u2013292.","journal-title":"Toxicological Sciences"},{"key":"10267_CR14","doi-asserted-by":"crossref","unstructured":"Mouton, A. J., El Hajj, E. C., Ninh, V. K., Siggins, R. W., & Gardner, J. D. (2020). Inflammatory cardiac fibroblast phenotype underlies chronic alcohol-induced cardiac atrophy and dysfunction. Life Sciences, 245, 117330.","DOI":"10.1016\/j.lfs.2020.117330"},{"issue":"4","key":"10267_CR15","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1111\/bph.15340","volume":"178","author":"M Yang","year":"2021","unstructured":"Yang, M., Wang, S., Fu, S., Wu, N. N., Xu, X., Sun, S., Zhang, Y., & Ren, J. (2021). Deletion of the E3 ubiquitin ligase, Parkin, exacerbates chronic alcohol intake-induced cardiomyopathy through an Ambra1-dependent mechanism. British Journal of Pharmacology, 178(4), 964\u2013982.","journal-title":"British Journal of Pharmacology"},{"key":"10267_CR16","doi-asserted-by":"crossref","unstructured":"Nakashima, M. A., Silva, C. B. P., Gonzaga, N. A., Simplicio, J. A., Omoto, A. C. M., Tirapelli, L. F., Tanus-Santos, J. E., & Tirapelli, C. R. (2019). Chronic ethanol consumption increases reactive oxygen species generation and the synthesis of pro-inflammatory proteins in the heart through TNFR1-dependent mechanisms. Cytokine, 121, 154734.","DOI":"10.1016\/j.cyto.2019.154734"},{"key":"10267_CR17","doi-asserted-by":"crossref","unstructured":"Wang, W., Liu, T., Liu, Y., Yu, L., Yan, X., Weng, W., Lu, X., & Zhang, C. (2021). Astaxanthin attenuates alcoholic cardiomyopathy via inhibition of endoplasmic reticulum stress-mediated cardiac apoptosis. Toxicol and Applied Pharmacology, 412, 115378.","DOI":"10.1016\/j.taap.2020.115378"},{"key":"10267_CR18","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.toxlet.2019.08.010","volume":"315","author":"VK Ninh","year":"2019","unstructured":"Ninh, V. K., El Hajj, E. C., Ronis, M. J., & Gardner, J. D. (2019). N-acetylcysteine prevents the decreases in cardiac collagen I\/III ratio and systolic function in neonatal mice with prenatal alcohol exposure. Toxicology Letters, 315, 87\u201395.","journal-title":"Toxicology Letters"},{"key":"10267_CR19","doi-asserted-by":"crossref","unstructured":"Nguyen, V. B., Probyn, M. E., Campbell, F., Yin, K. V., Samuel, C. S., Zimanyi, M. A., Bertram, J. F., Black, M. J., & Moritz, K. M. (2014). Low-dose maternal alcohol consumption: Effects in the hearts of offspring in early life and adulthood. Physiological Reports, 2(7), e12087.","DOI":"10.14814\/phy2.12087"},{"issue":"1","key":"10267_CR20","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1093\/alcalc\/37.1.30","volume":"37","author":"J Ren","year":"2002","unstructured":"Ren, J., Wold, L. E., Natavio, M., Ren, B. H., Hannigan, J. H., & Brown, R. A. (2002). Influence of prenatal alcohol exposure on myocardial contractile function in adult rat hearts: Role of intracellular calcium and apoptosis. Alcohol and Alcoholism, 37(1), 30\u201337.","journal-title":"Alcohol and Alcoholism"},{"issue":"4","key":"10267_CR21","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3390\/toxics5040035","volume":"5","author":"S Sarmah","year":"2017","unstructured":"Sarmah, S., & Marrs, J. A. (2017). Embryonic ethanol exposure affects early- and late-added cardiac precursors and produces long-lasting heart chamber defects in zebrafish. Toxics, 5(4), 35.","journal-title":"Toxics"},{"issue":"1","key":"10267_CR22","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1186\/s12967-018-1649-6","volume":"16","author":"GR Guo","year":"2018","unstructured":"Guo, G. R., Chen, L., Rao, M., Chen, K., Song, J. P., & Hu, S. S. (2018). A modified method for isolation of human cardiomyocytes to model cardiac diseases. Journal of Translational Medicine, 16(1), 288.","journal-title":"Journal of Translational Medicine"},{"issue":"2","key":"10267_CR23","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/S0008-6363(98)00128-X","volume":"39","author":"JS Mitcheson","year":"1998","unstructured":"Mitcheson, J. S., Hancox, J. C., & Levi, A. J. (1998). Cultured adult cardiac myocytes: Future applications, culture methods, morphological and electrophysiological properties. Cardiovascular Research, 39(2), 280\u2013300.","journal-title":"Cardiovascular Research"},{"issue":"3","key":"10267_CR24","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.chembiol.2021.02.016","volume":"28","author":"AP Hnatiuk","year":"2021","unstructured":"Hnatiuk, A. P., Briganti, F., Staudt, D. W., & Mercola, M. (2021). Human iPSC modeling of heart disease for drug development. Cell Chemical Biology, 28(3), 271\u2013282.","journal-title":"Cell Chemical Biology"},{"issue":"3","key":"10267_CR25","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.stemcr.2021.01.018","volume":"16","author":"WE Knight","year":"2021","unstructured":"Knight, W. E., Cao, Y., Lin, Y. H., Chi, C., Bai, B., Sparagna, G. C., Zhao, Y., Du, Y., Londono, P., Reisz, J. A., et al. (2021). Maturation of pluripotent stem cell-derived cardiomyocytes enables modeling of human hypertrophic cardiomyopathy. Stem Cell Reports, 16(3), 519\u2013533.","journal-title":"Stem Cell Reports"},{"issue":"10","key":"10267_CR26","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1016\/j.jacc.2019.12.066","volume":"75","author":"F Kamdar","year":"2020","unstructured":"Kamdar, F., Das, S., Gong, W., Klaassen Kamdar, A., Meyers, T. A., Shah, P., Ervasti, J. M., Townsend, D., Kamp, T. J., Wu, J. C., et al. (2020). Stem cell-derived cardiomyocytes and beta-adrenergic receptor blockade in Duchenne muscular dystrophy cardiomyopathy. Journal of the American College of Cardiology, 75(10), 1159\u20131174.","journal-title":"Journal of the American College of Cardiology"},{"key":"10267_CR27","doi-asserted-by":"crossref","unstructured":"McDermott-Roe, C., Lv, W., Maximova, T., Wada, S., Bukowy, J., Marquez, M., Lai, S., Shehu, A., Benjamin, I., Geurts, A., et al. (2019). Investigation of a dilated cardiomyopathy-associated variant in BAG3 using genome-edited iPSC-derived cardiomyocytes. JCI Insight, 4(22), e128799.","DOI":"10.1172\/jci.insight.128799"},{"issue":"21","key":"10267_CR28","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.1161\/CIRCULATIONAHA.118.037357","volume":"139","author":"T Kitani","year":"2019","unstructured":"Kitani, T., Ong, S. G., Lam, C. K., Rhee, J. W., Zhang, J. Z., Oikonomopoulos, A., Ma, N., Tian, L., Lee, J., Telli, M. L., et al. (2019). Human induced pluripotent stem cell model of trastuzumab-induced cardiac dysfunction in breast cancer patients. Circulation, 139(21), 2451\u20132465.","journal-title":"Circulation"},{"issue":"1","key":"10267_CR29","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1186\/s13287-020-01984-1","volume":"11","author":"R Liu","year":"2020","unstructured":"Liu, R., Li, D., Sun, F., Rampoldi, A., Maxwell, J. T., Wu, R., Fischbach, P., Castellino, S. M., Du, Y., Fu, H., et al. (2020). Melphalan induces cardiotoxicity through oxidative stress in cardiomyocytes derived from human induced pluripotent stem cells. Stem Cell Research & Therapy, 11(1), 470.","journal-title":"Stem Cell Research & Therapy"},{"issue":"11","key":"10267_CR30","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1111\/acer.14471","volume":"44","author":"R Liu","year":"2020","unstructured":"Liu, R., Sun, F., Forghani, P., Armand, L. C., Rampoldi, A., Li, D., Wu, R., & Xu, C. (2020). Proteomic profiling reveals roles of stress response, Ca(2+) transient dysregulation, and novel signaling pathways in alcohol-induced cardiotoxicity. Alcoholism, Clinical and Experimental Research, 44(11), 2187\u20132199.","journal-title":"Alcoholism, Clinical and Experimental Research"},{"key":"10267_CR31","doi-asserted-by":"crossref","unstructured":"Rhee, J. W., Yi, H., Thomas, D., Lam, C. K., Belbachir, N., Tian, L., Qin, X., Malisa, J., Lau, E., Paik, D. T., et al. (2020). Modeling secondary iron overload cardiomyopathy with human induced pluripotent stem cell-derived cardiomyocytes. Cell Reports, 32(2), 107886.","DOI":"10.1016\/j.celrep.2020.107886"},{"key":"10267_CR32","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/978-1-4939-2572-8_9","volume":"1299","author":"R Jha","year":"2015","unstructured":"Jha, R., Xu, R. H., & Xu, C. (2015). Efficient differentiation of cardiomyocytes from human pluripotent stem cells with growth factors. Methods in Molecular Biology, 1299, 115\u2013131.","journal-title":"Methods in Molecular Biology"},{"issue":"9","key":"10267_CR33","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1038\/nbt1327","volume":"25","author":"MA Laflamme","year":"2007","unstructured":"Laflamme, M. A., Chen, K. Y., Naumova, A. V., Muskheli, V., Fugate, J. A., Dupras, S. K., Reinecke, H., Xu, C., Hassanipour, M., Police, S., et al. (2007). Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nature Biotechnology, 25(9), 1015\u20131024.","journal-title":"Nature Biotechnology"},{"key":"10267_CR34","doi-asserted-by":"publisher","first-page":"30956","DOI":"10.1038\/srep30956","volume":"6","author":"R Jha","year":"2016","unstructured":"Jha, R., Wu, Q., Singh, M., Preininger, M. K., Han, P., Ding, G., Cho, H. C., Jo, H., Maher, K. O., Wagner, M. B., et al. (2016). Simulated microgravity and 3D culture enhance induction, viability, proliferation and differentiation of cardiac progenitors from human pluripotent stem cells. Science and Reports, 6, 30956.","journal-title":"Science and Reports"},{"key":"10267_CR35","doi-asserted-by":"crossref","unstructured":"Brahm, J. (1983) Permeability of human red cells to a homologous series of aliphatic alcohols. Limitations of the continuous flow-tube method. Journal of General Physiology, 81(2), 283\u2013304.","DOI":"10.1085\/jgp.81.2.283"},{"key":"10267_CR36","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.yjmcc.2019.05.003","volume":"132","author":"C Gentillon","year":"2019","unstructured":"Gentillon, C., Li, D., Duan, M., Yu, W. M., Preininger, M. K., Jha, R., Rampoldi, A., Saraf, A., Gibson, G. C., Qu, C. K., et al. (2019). Targeting HIF-1alpha in combination with PPARalpha activation and postnatal factors promotes the metabolic maturation of human induced pluripotent stem cell-derived cardiomyocytes. Journal of Molecular and Cellular Cardiology, 132, 120\u2013135.","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"5","key":"10267_CR37","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1089\/ten.tec.2014.0283","volume":"21","author":"N Huebsch","year":"2015","unstructured":"Huebsch, N., Loskill, P., Mandegar, M. A., Marks, N. C., Sheehan, A. S., Ma, Z., Mathur, A., Nguyen, T. N., Yoo, J. C., Judge, L. M., et al. (2015). Automated video-based analysis of contractility and calcium flux in human-induced pluripotent stem cell-derived cardiomyocytes cultured over different spatial scales. Tissue Engineering. Part C, Methods, 21(5), 467\u2013479.","journal-title":"Tissue Engineering. Part C, Methods"},{"issue":"1","key":"10267_CR38","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou, Y., Zhou, B., Pache, L., Chang, M., Khodabakhshi, A. H., Tanaseichuk, O., Benner, C., & Chanda, S. K. (2019). Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nature Communications, 10(1), 1523.","journal-title":"Nature Communications"},{"key":"10267_CR39","unstructured":"Intoximeters. Alcohol and the human body. Available at: https:\/\/www.intox.com\/physiology\/ (Accessed 27 Feb 2021)."},{"issue":"3","key":"10267_CR40","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.scr.2016.04.014","volume":"16","author":"J Han","year":"2016","unstructured":"Han, J., Wu, Q., Xia, Y., Wagner, M. B., & Xu, C. (2016). Cell alignment induced by anisotropic electrospun fibrous scaffolds alone has limited effect on cardiomyocyte maturation. Stem Cell Res, 16(3), 740\u2013750.","journal-title":"Stem Cell Res"},{"issue":"3","key":"10267_CR41","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1002\/bit.26504","volume":"115","author":"C Correia","year":"2018","unstructured":"Correia, C., Koshkin, A., Duarte, P., Hu, D., Carido, M., Sebastiao, M. J., Gomes-Alves, P., Elliott, D. A., Domian, I. J., Teixeira, A. P., et al. (2018). 3D aggregate culture improves metabolic maturation of human pluripotent stem cell derived cardiomyocytes. Biotechnology and Bioengineering, 115(3), 630\u2013644.","journal-title":"Biotechnology and Bioengineering"},{"key":"10267_CR42","doi-asserted-by":"crossref","unstructured":"Fiedler, L. R., Chapman, K., Xie, M., Maifoshie, E., Jenkins, M., Golforoush, P. A., Bellahcene, M., Noseda, M., Faust, D., Jarvis, A., et al. (2019). MAP4K4 inhibition promotes survival of human stem cell-derived cardiomyocytes and reduces infarct size in vivo. Cell Stem Cell, 24(4), 579\u2013591 e512.","DOI":"10.1016\/j.stem.2019.01.013"},{"key":"10267_CR43","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3389\/fphar.2018.00006","volume":"9","author":"SA Langhans","year":"2018","unstructured":"Langhans, S. A. (2018). Three-dimensional in vitro cell culture models in drug discovery and drug repositioning. Frontiers in Pharmacology, 9, 6.","journal-title":"Frontiers in Pharmacology"},{"key":"10267_CR44","doi-asserted-by":"crossref","unstructured":"Duval, K., Grover, H., Han, L. H., Mou, Y., Pegoraro, A. F., Fredberg, J., & Chen, Z. (2017). Modeling physiological events in 2D vs. 3D cell culture. Physiology (Bethesda), 32(4), 266\u2013277.","DOI":"10.1152\/physiol.00036.2016"},{"issue":"5","key":"10267_CR45","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1161\/CIRCULATIONAHA.119.039711","volume":"140","author":"SJ Park","year":"2019","unstructured":"Park, S. J., Zhang, D., Qi, Y., Li, Y., Lee, K. Y., Bezzerides, V. J., Yang, P., Xia, S., Kim, S. L., Liu, X., et al. (2019). Insights into the pathogenesis of catecholaminergic polymorphic ventricular tachycardia from engineered human heart tissue. Circulation, 140(5), 390\u2013404.","journal-title":"Circulation"},{"issue":"1","key":"10267_CR46","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s12012-019-09533-w","volume":"20","author":"C Ellermann","year":"2020","unstructured":"Ellermann, C., Mittelstedt, A., Wolfes, J., Willy, K., Leitz, P., Reinke, F., Eckardt, L., & Frommeyer, G. (2020). Action potential triangulation explains acute proarrhythmic effect of aliskiren in a whole-heart model of atrial fibrillation. Cardiovascular Toxicology, 20(1), 49\u201357.","journal-title":"Cardiovascular Toxicology"},{"key":"10267_CR47","doi-asserted-by":"crossref","unstructured":"Lan, H., Xu, Q., El-Battrawy, I., Zhong, R., Li, X., Lang, S., Cyganek, L., Borggrefe, M., Zhou, X., & Akin, I. (2020). Ionic mechanisms of disopyramide prolonging action potential duration in human-induced pluripotent stem cell-derived cardiomyocytes from a patient with short QT syndrome type 1. Frontiers in Pharmacology, 11, 554422.","DOI":"10.3389\/fphar.2020.554422"},{"issue":"8","key":"10267_CR48","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1016\/j.bpj.2015.03.011","volume":"108","author":"Z Song","year":"2015","unstructured":"Song, Z., Ko, C. Y., Nivala, M., Weiss, J. N., & Qu, Z. (2015). Calcium-voltage coupling in the genesis of early and delayed afterdepolarizations in cardiac myocytes. Biophysical Journal, 108(8), 1908\u20131921.","journal-title":"Biophysical Journal"},{"issue":"12","key":"10267_CR49","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1161\/CIRCRESAHA.117.310083","volume":"120","author":"AP Landstrom","year":"2017","unstructured":"Landstrom, A. P., Dobrev, D., & Wehrens, X. H. T. (2017). Calcium signaling and cardiac arrhythmias. Circulation Research, 120(12), 1969\u20131993.","journal-title":"Circulation Research"},{"key":"10267_CR50","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.yjmcc.2020.07.007","volume":"146","author":"H Sutanto","year":"2020","unstructured":"Sutanto, H., Cluitmans, M. J. M., Dobrev, D., Volders, P. G. A., Bebarova, M., & Heijman, J. (2020). Acute effects of alcohol on cardiac electrophysiology and arrhythmogenesis: Insights from multiscale in silico analyses. Journal of Molecular and Cellular Cardiology, 146, 69\u201383.","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10267_CR51","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3389\/fphys.2016.00313","volume":"7","author":"G Tse","year":"2016","unstructured":"Tse, G., Yan, B. P., Chan, Y. W., Tian, X. Y., & Huang, Y. (2016). Reactive oxygen species, endoplasmic reticulum stress and mitochondrial dysfunction: The link with cardiac arrhythmogenesis. Frontiers in Physiology, 7, 313.","journal-title":"Frontiers in Physiology"},{"issue":"Pt 2","key":"10267_CR52","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1242\/jeb.124941","volume":"219","author":"M Gautel","year":"2016","unstructured":"Gautel, M., & Djinovic-Carugo, K. (2016). The sarcomeric cytoskeleton: From molecules to motion. Journal of Experimental Biology, 219(Pt 2), 135\u2013145.","journal-title":"Journal of Experimental Biology"},{"issue":"12","key":"10267_CR53","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1111\/j.1530-0277.2000.tb01987.x","volume":"24","author":"J Fernandez-Sola","year":"2000","unstructured":"Fernandez-Sola, J., Nicolas, J. M., Pare, J. C., Sacanella, E., Fatjo, F., Cofan, M., & Estruch, R. (2000). Diastolic function impairment in alcoholics. Alcoholism, Clinical and Experimental Research, 24(12), 1830\u20131835.","journal-title":"Alcoholism, Clinical and Experimental Research"},{"issue":"6","key":"10267_CR54","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1097\/00005344-200412000-00012","volume":"44","author":"Z Guan","year":"2004","unstructured":"Guan, Z., Lui, C. Y., Morkin, E., & Bahl, J. J. (2004). Oxidative stress and apoptosis in cardiomyocyte induced by high-dose alcohol. Journal of Cardiovascular Pharmacology, 44(6), 696\u2013702.","journal-title":"Journal of Cardiovascular Pharmacology"},{"issue":"10","key":"10267_CR55","doi-asserted-by":"publisher","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","volume":"24","author":"M Schieber","year":"2014","unstructured":"Schieber, M., & Chandel, N. S. (2014). ROS function in redox signaling and oxidative stress. Current Biology, 24(10), R453-462.","journal-title":"Current Biology"},{"key":"10267_CR56","doi-asserted-by":"publisher","first-page":"9030563","DOI":"10.1155\/2019\/9030563","volume":"2019","author":"T Xu","year":"2019","unstructured":"Xu, T., Ding, W., Ji, X., Ao, X., Liu, Y., Yu, W., & Wang, J. (2019). Oxidative stress in cell death and cardiovascular diseases. Oxidative Medicine and Cellular Longevity, 2019, 9030563.","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"5","key":"10267_CR57","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1161\/CIRCRESAHA.114.302533","volume":"114","author":"M Rienks","year":"2014","unstructured":"Rienks, M., Papageorgiou, A. P., Frangogiannis, N. G., & Heymans, S. (2014). Myocardial extracellular matrix: An ever-changing and diverse entity. Circulation Research, 114(5), 872\u2013888.","journal-title":"Circulation Research"},{"issue":"20","key":"10267_CR58","doi-asserted-by":"publisher","first-page":"5054","DOI":"10.3390\/ijms20205054","volume":"20","author":"N Bildyug","year":"2019","unstructured":"Bildyug, N. (2019). Extracellular matrix in regulation of contractile system in cardiomyocytes. International Journal of Molecular Sciences, 20(20), 5054.","journal-title":"International Journal of Molecular Sciences"},{"key":"10267_CR59","doi-asserted-by":"crossref","unstructured":"Bi, X., Song, Y., Song, Y., Yuan, J., Cui, J., Zhao, S., & Qiao, S. (2021). Collagen cross-linking is associated with cardiac remodeling in hypertrophic obstructive cardiomyopathy. Journal of the American Heart Association, 10(1), e017752.","DOI":"10.1161\/JAHA.120.017752"},{"issue":"1","key":"10267_CR60","doi-asserted-by":"publisher","first-page":"12352","DOI":"10.1038\/s41598-020-69254-x","volume":"10","author":"R Johnson","year":"2020","unstructured":"Johnson, R., Nxele, X., Cour, M., Sangweni, N., Jooste, T., Hadebe, N., Samodien, E., Benjeddou, M., Mazino, M., Louw, J., et al. (2020). Identification of potential biomarkers for predicting the early onset of diabetic cardiomyopathy in a mouse model. Science and Reports, 10(1), 12352.","journal-title":"Science and Reports"},{"issue":"1","key":"10267_CR61","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12916-019-1469-4","volume":"18","author":"X Hua","year":"2020","unstructured":"Hua, X., Wang, Y. Y., Jia, P., Xiong, Q., Hu, Y., Chang, Y., Lai, S., Xu, Y., Zhao, Z., & Song, J. (2020). Multi-level transcriptome sequencing identifies COL1A1 as a candidate marker in human heart failure progression. BMC Medicine, 18(1), 2.","journal-title":"BMC Medicine"},{"issue":"5","key":"10267_CR62","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.3892\/etm.2017.4246","volume":"13","author":"G Liu","year":"2017","unstructured":"Liu, G., Ma, C., Yang, H., & Zhang, P. Y. (2017). Transforming growth factor beta and its role in heart disease. Experimental and Therapeutic Medicine, 13(5), 2123\u20132128.","journal-title":"Experimental and Therapeutic Medicine"},{"issue":"6","key":"10267_CR63","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1113\/jphysiol.2012.235382","volume":"591","author":"K Dawson","year":"2013","unstructured":"Dawson, K., Aflaki, M., & Nattel, S. (2013). Role of the Wnt-Frizzled system in cardiac pathophysiology: A rapidly developing, poorly understood area with enormous potential. Journal of Physiology, 591(6), 1409\u20131432.","journal-title":"Journal of Physiology"},{"issue":"1","key":"10267_CR64","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12964-020-00555-4","volume":"18","author":"F Yousefi","year":"2020","unstructured":"Yousefi, F., Shabaninejad, Z., Vakili, S., Derakhshan, M., Movahedpour, A., Dabiri, H., Ghasemi, Y., Mahjoubin-Tehran, M., Nikoozadeh, A., Savardashtaki, A., et al. (2020). TGF-beta and WNT signaling pathways in cardiac fibrosis: Non-coding RNAs come into focus. Cell Communication and Signaling: CCS, 18(1), 87.","journal-title":"Cell Communication and Signaling: CCS"},{"issue":"1","key":"10267_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00395-017-0659-5","volume":"113","author":"NM Landry","year":"2018","unstructured":"Landry, N. M., Cohen, S., & Dixon, I. M. C. (2018). Periostin in cardiovascular disease and development: A tale of two distinct roles. Basic Research in Cardiology, 113(1), 1.","journal-title":"Basic Research in Cardiology"},{"key":"10267_CR66","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fcvm.2018.00010","volume":"5","author":"JC Gross","year":"2018","unstructured":"Gross, J. C., & Zelarayan, L. C. (2018). The mingle-mangle of Wnt signaling and extracellular vesicles: Functional implications for heart research. Frontiers in Cardiovascular Medicine, 5, 10.","journal-title":"Frontiers in Cardiovascular Medicine"},{"key":"10267_CR67","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3389\/fcvm.2019.00140","volume":"6","author":"A Hanna","year":"2019","unstructured":"Hanna, A., & Frangogiannis, N. G. (2019). The role of the TGF-beta superfamily in myocardial infarction. Frontiers in Cardiovascular Medicine, 6, 140.","journal-title":"Frontiers in Cardiovascular Medicine"}],"container-title":["Stem Cell Reviews and Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-021-10267-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12015-021-10267-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-021-10267-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T17:16:47Z","timestamp":1675703807000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12015-021-10267-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,25]]},"references-count":67,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10267"],"URL":"https:\/\/doi.org\/10.1007\/s12015-021-10267-y","relation":{},"ISSN":["2629-3269","2629-3277"],"issn-type":[{"value":"2629-3269","type":"print"},{"value":"2629-3277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,25]]},"assertion":[{"value":"17 September 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no disclosures to report and declare no competing financial interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}