{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:12:36Z","timestamp":1787620356465,"version":"build-2736575974"},"reference-count":104,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11702044"],"award-info":[{"award-number":["11702044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11902061"],"award-info":[{"award-number":["11902061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["cstc2020jcyj-msxmX0350"],"award-info":[{"award-number":["cstc2020jcyj-msxmX0350"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Rev and Rep"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s12015-021-10286-9","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T21:40:44Z","timestamp":1634679644000},"page":"77-93","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Stem Cell-based Therapy Strategy for Hepatic Fibrosis by Targeting Intrahepatic Cells"],"prefix":"10.1007","volume":"18","author":[{"given":"Yaxin","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggang","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4970-0326","authenticated-orcid":false,"given":"Guobao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"10286_CR1","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.matbio.2017.11.002","volume":"66","author":"O Molokanova","year":"2018","unstructured":"Molokanova, O., Sch\u00f6nig, K., Weng, S. Y., Wang, X., Bros, M., Diken, M., et al. (2018). Inducible knockdown of procollagen I protects mice from liver fibrosis and leads to dysregulated matrix genes and attenuated inflammation. Matrix Biology, 66, 34\u201349","journal-title":"Matrix Biology"},{"issue":"5","key":"10286_CR2","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1634\/stemcells.2007-0941","volume":"26","author":"AB Carvalho","year":"2008","unstructured":"Carvalho, A. B., Quintanilha, L. F., Dias, J. V., Paredes, B. D., Mannheimer, E. G., Carvalho, F. G., et al. (2008). Bone marrow multipotent mesenchymal stromal cells do not reduce fibrosis or improve function in a rat model of severe chronic liver injury. Stem Cells, 26(5), 1307\u20131314","journal-title":"Stem Cells"},{"key":"10286_CR3","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1038\/ncomms3823","volume":"4","author":"I Mederacke","year":"2013","unstructured":"Mederacke, I., Hsu, C. C., Troeger, J. S., Huebener, P., Mu, X., Dapito, D. H., et al. (2013). Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology. Nature Communications, 4, 2823","journal-title":"Nature Communications"},{"issue":"3","key":"10286_CR4","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1002\/hep.26470","volume":"58","author":"A Seki","year":"2013","unstructured":"Seki, A., Sakai, Y., Komura, T., Nasti, A., Yoshida, K., Higashimoto, M., et al. (2013). Adipose tissue-derived stem cells as a regenerative therapy for a mouse steatohepatitis-induced cirrhosis model. Hepatology, 58(3), 1133\u20131142","journal-title":"Hepatology"},{"issue":"8","key":"10286_CR5","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1038\/cr.2015.84","volume":"25","author":"H Qian","year":"2015","unstructured":"Qian, H., Deng, X., Huang, Z. W., Wei, J., Ding, C. H., Feng, R. X., et al. (2015). An HNF1\u03b1-regulated feedback circuit modulates hepatic fibrogenesis via the crosstalk between hepatocytes and hepatic stellate cells. Cell Research, 25(8), 930\u2013945","journal-title":"Cell Research"},{"issue":"5","key":"10286_CR6","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1002\/hep.24815","volume":"55","author":"L Liu","year":"2012","unstructured":"Liu, L., Yannam, G. R., Nishikawa, T., Yamamoto, T., Basma, H., Ito, R., et al. (2012). The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis. Hepatology, 55(5), 1529\u20131539","journal-title":"Hepatology"},{"issue":"7","key":"10286_CR7","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.3390\/ijms20071629","volume":"20","author":"P Pingitore","year":"2019","unstructured":"Pingitore, P., Sasidharan, K., Ekstrand, M., Prill, S., Lind\u00e9n, D., & Romeo, S. (2019). Human multilineage 3D spheroids as a model of liver steatosis and fibrosis. International Journal of Molecular Sciences, 20(7), 1629","journal-title":"International Journal of Molecular Sciences"},{"issue":"1 Suppl","key":"10286_CR8","doi-asserted-by":"publisher","first-page":"S115","DOI":"10.1016\/j.bbmt.2009.10.035","volume":"16","author":"R Jones","year":"2010","unstructured":"Jones, R., Lebkowski, J., & McNiece, I. (2010). Stem cells. Biology of Blood and Marrow Transplantation, 16(1 Suppl), S115\u2013S118","journal-title":"Biology of Blood and Marrow Transplantation"},{"key":"10286_CR9","doi-asserted-by":"publisher","first-page":"104720","DOI":"10.1016\/j.phrs.2020.104720","volume":"155","author":"X Cai","year":"2020","unstructured":"Cai, X., Wang, J., Wang, J., Zhou, Q., Yang, B., He, Q., et al. (2020). Intercellular crosstalk of hepatic stellate cells in liver fibrosis: New insights into therapy. Pharmacological Research, 155, 104720","journal-title":"Pharmacological Research"},{"issue":"1","key":"10286_CR10","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s13287-017-0575-5","volume":"8","author":"M Najimi","year":"2017","unstructured":"Najimi, M., Berardis, S., El-Kehdy, H., Rosseels, V., Evraerts, J., Lombard, C., et al. (2017). Human liver mesenchymal stem\/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation. Stem Cell Research & Therapy, 8(1), 131","journal-title":"Stem Cell Research & Therapy"},{"key":"10286_CR11","doi-asserted-by":"publisher","first-page":"8616","DOI":"10.1038\/srep08616","volume":"5","author":"M Park","year":"2015","unstructured":"Park, M., Kim, Y. H., Woo, S. Y., Lee, H. J., Yu, Y., Kim, H. S., et al. (2015). Tonsil-derived mesenchymal stem cells ameliorate CCl4-induced liver fibrosis in mice via autophagy activation. Scientific Reports, 5, 8616","journal-title":"Scientific Reports"},{"issue":"1","key":"10286_CR12","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s13287-018-0814-4","volume":"9","author":"Y Zhang","year":"2018","unstructured":"Zhang, Y., Li, Y., Zhang, L., Li, J., & Zhu, C. (2018). Mesenchymal stem cells: potential application for the treatment of hepatic cirrhosis. Stem Cell Research & Therapy, 9(1), 59","journal-title":"Stem Cell Research & Therapy"},{"key":"10286_CR13","doi-asserted-by":"crossref","unstructured":"Yang, X., Han, Z. P., Zhang, S. S., Zhu, P. X., Hao, C., Fan, T. T., et al. (2014). Chronic restraint stress decreases the repair potential from mesenchymal stem cells on liver injury by inhibiting TGF-\u03b21 generation.\u00a0Cell Death and Disease, 5(6), e1308","DOI":"10.1038\/cddis.2014.257"},{"issue":"2","key":"10286_CR14","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3350\/cmh.2015.21.2.141","volume":"21","author":"YO Jang","year":"2015","unstructured":"Jang, Y. O., Jun, B. G., Baik, S. K., Kim, M. Y., & Kwon, S. O. (2015). Inhibition of hepatic stellate cells by bone marrow-derived mesenchymal stem cells in hepatic fibrosis. Clinical and Molecular Hepatology, 21(2), 141\u2013149","journal-title":"Clinical and Molecular Hepatology"},{"key":"10286_CR15","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12967-016-0792-1","volume":"14","author":"B Huang","year":"2016","unstructured":"Huang, B., Cheng, X., Wang, H., Huang, W., la Ga Hu, Z., Wang, D., et al. (2016). Mesenchymal stem cells and their secreted molecules predominantly ameliorate fulminant hepatic failure and chronic liver fibrosis in mice respectively. Journal of Translational Medicine, 14, 45","journal-title":"Journal of Translational Medicine"},{"key":"10286_CR16","doi-asserted-by":"crossref","unstructured":"Ribot, E. J., Gaudet, J. M., Chen, Y., Gilbert, K. M., & Foster, P. J. (2014). In vivo MR detection of fluorine-labeled human MSC using the bSSFP sequence.\u00a0International Journal of Nanomedicine, 9, 1731-1739","DOI":"10.2147\/IJN.S59127"},{"key":"10286_CR17","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3389\/fimmu.2014.00148","volume":"5","author":"E Eggenhofer","year":"2014","unstructured":"Eggenhofer, E., Luk, F., Dahlke, M. H., & Hoogduijn, M. J. (2014). The life and fate of mesenchymal stem cells. Frontiers in Immunology, 5, 148","journal-title":"Frontiers in Immunology"},{"issue":"6B","key":"10286_CR18","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1111\/j.1582-4934.2009.00912.x","volume":"14","author":"Y Chen","year":"2010","unstructured":"Chen, Y., Xiang, L. X., Shao, J. Z., Pan, R. L., Wang, Y. X., Dong, X. J., et al. (2010). Recruitment of endogenous bone marrow mesenchymal stem cells towards injured liver. Journal of Cellular and Molecular Medicine, 14(6B), 1494\u20131508","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"11","key":"10286_CR19","doi-asserted-by":"publisher","first-page":"2963","DOI":"10.1111\/jcmm.13208","volume":"21","author":"G Lou","year":"2017","unstructured":"Lou, G., Yang, Y., Liu, F., Ye, B., Chen, Z., Zheng, M., et al. (2017). MiR-122 modification enhances the therapeutic efficacy of adipose tissue-derived mesenchymal stem cells against liver fibrosis. Journal of Cellular and Molecular Medicine, 21(11), 2963\u20132973","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"3","key":"10286_CR20","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/s12288-015-0581-7","volume":"32","author":"NM Al Ghrbawy","year":"2016","unstructured":"Al Ghrbawy, N. M., Afify, R. A., Dyaa, N., & El Sayed, A. A. (2016). Differentiation of bone marrow: derived mesenchymal stem cells into hepatocyte-like cells. Indian J Hematol Blood Transfus, 32(3), 276\u2013283","journal-title":"Indian J Hematol Blood Transfus"},{"issue":"10","key":"10286_CR21","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1097\/PAI.0000000000000373","volume":"25","author":"SF Ewida","year":"2017","unstructured":"Ewida, S. F., Abdou, A. G., El-Rasol Elhosary, A. A., & El-Ghane Metawe, S. A. (2017). Hepatocyte-like versus mesenchymal stem cells in CCl4-induced liver fibrosis. Applied Immunohistochemistry & Molecular Morphology, 25(10), 736\u2013745","journal-title":"Applied Immunohistochemistry & Molecular Morphology"},{"key":"10286_CR22","doi-asserted-by":"crossref","unstructured":"Kim, M. D., Kim, S. S., Cha, H. Y., Jang, S. H., Chang, D. Y., Kim, W., et al. (2014). Therapeutic effect of hepatocyte growth factor-secreting mesenchymal stem cells in a rat model of liver fibrosis.\u00a0Experimental & Molecular Medicine, 46(8), e110","DOI":"10.1038\/emm.2014.49"},{"issue":"6","key":"10286_CR23","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1016\/j.jhep.2009.01.028","volume":"50","author":"C Li","year":"2009","unstructured":"Li, C., Kong, Y., Wang, H., Wang, S., Yu, H., Liu, X., et al. (2009). Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis. Journal of Hepatology, 50(6), 1174\u20131183","journal-title":"Journal of Hepatology"},{"issue":"6","key":"10286_CR24","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1053\/j.gastro.2006.01.036","volume":"130","author":"FP Russo","year":"2006","unstructured":"Russo, F. P., Alison, M. R., Bigger, B. W., Amofah, E., Florou, A., Amin, F., et al. (2006). The bone marrow functionally contributes to liver fibrosis. Gastroenterology, 130(6), 1807\u20131821","journal-title":"Gastroenterology"},{"issue":"2","key":"10286_CR25","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1136\/gut.2006.111617","volume":"57","author":"LV di Bonzo","year":"2008","unstructured":"di Bonzo, L. V., Ferrero, I., Cravanzola, C., Mareschi, K., Rustichell, D., Novo, E., et al. (2008). Human mesenchymal stem cells as a two-edged sword in hepatic regenerative medicine: engraftment and hepatocyte differentiation versus profibrogenic potential. Gut, 57(2), 223\u2013231","journal-title":"Gut"},{"issue":"3","key":"10286_CR26","doi-asserted-by":"publisher","first-page":"590","DOI":"10.3390\/cells9030590","volume":"9","author":"D Overi","year":"2020","unstructured":"Overi, D., Carpino, G., Franchitto, A., Onori, P., & Gaudio, E. (2020). Hepatocyte injury and hepatic stem cell niche in the progression of non-alcoholic steatohepatitis. Cells, 9(3), 590","journal-title":"Cells"},{"issue":"6","key":"10286_CR27","first-page":"5956","volume":"14","author":"T Hao","year":"2017","unstructured":"Hao, T., Chen, J., Zhi, S., Zhang, Q., Chen, G., & Yu, F. (2017). Comparison of bone marrow-vs. adipose tissue-derived mesenchymal stem cells for attenuating liver fibrosis. Experimental and Therapeutic Medicine, 14(6), 5956\u20135964","journal-title":"Experimental and Therapeutic Medicine"},{"issue":"3","key":"10286_CR28","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.jhep.2014.10.030","volume":"62","author":"RP Meier","year":"2015","unstructured":"Meier, R. P., Mahou, R., Morel, P., Meyer, J., Montanari, E., Muller, Y. D., et al. (2015). Microencapsulated human mesenchymal stem cells decrease liver fibrosis in mice. Journal of Hepatology, 62(3), 634\u2013641","journal-title":"Journal of Hepatology"},{"issue":"1","key":"10286_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3727\/000000003783985179","volume":"12","author":"L Rambhatla","year":"2003","unstructured":"Rambhatla, L., Chiu, C. P., Kundu, P., Peng, Y., & Carpenter, M. K. (2003). Generation of hepatocyte-like cells from human embryonic stem cells. Cell Transplantation, 12(1), 1\u201311","journal-title":"Cell Transplantation"},{"issue":"1","key":"10286_CR30","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/mt.2011.234","volume":"20","author":"K Takayama","year":"2012","unstructured":"Takayama, K., Inamura, M., Kawabata, K., Katayama, K., Higuchi, M., Tashiro, K., et al. (2012). Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4\u03b1 transduction. Molecular Therapy, 20(1), 127\u2013137","journal-title":"Molecular Therapy"},{"key":"10286_CR31","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1186\/s13287-015-0227-6","volume":"6","author":"L Tolosa","year":"2015","unstructured":"Tolosa, L., Caron, J., Hannoun, Z., Antoni, M., L\u00f3pez, S., Burks, D., et al. (2015). Transplantation of hESC-derived hepatocytes protects mice from liver injury. Stem Cell Research & Therapy, 6, 246","journal-title":"Stem Cell Research & Therapy"},{"issue":"5","key":"10286_CR32","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1053\/jhep.2003.50202","volume":"37","author":"H Yamamoto","year":"2003","unstructured":"Yamamoto, H., Quinn, G., Asari, A., Yamanokuchi, H., Teratani, T., Terada, M., et al. (2003). Differentiation of embryonic stem cells into hepatocytes: biological functions and therapeutic application. Hepatology, 37(5), 983\u2013993","journal-title":"Hepatology"},{"issue":"4","key":"10286_CR33","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1002\/hep.20629","volume":"41","author":"T Teratani","year":"2005","unstructured":"Teratani, T., Yamamoto, H., Aoyagi, K., Sasaki, H., Asari, A., Quinn, G., et al. (2005). Direct hepatic fate specification from mouse embryonic stem cells. Hepatology, 41(4), 836\u2013846","journal-title":"Hepatology"},{"issue":"3","key":"10286_CR34","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1053\/j.gastro.2011.11.030","volume":"142","author":"DH Woo","year":"2012","unstructured":"Woo, D. H., Kim, S. K., Lim, H. J., Heo, J., Park, H. S., Kang, G. Y., et al. (2012). Direct and indirect contribution of human embryonic stem cell-derived hepatocyte-like cells to liver repair in mice. Gastroenterology, 142(3), 602\u2013611","journal-title":"Gastroenterology"},{"key":"10286_CR35","doi-asserted-by":"publisher","first-page":"15166","DOI":"10.1038\/ncomms15166","volume":"8","author":"Q Li","year":"2017","unstructured":"Li, Q., Hutchins, A. P., Chen, Y., Li, S., Shan, Y., Liao, B., et al. (2017). A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes. Nature Communications, 8, 15166","journal-title":"Nature Communications"},{"issue":"82","key":"10286_CR36","doi-asserted-by":"publisher","first-page":"8239","DOI":"10.1126\/scitranslmed.3002376","volume":"3","author":"H Liu","year":"2011","unstructured":"Liu, H., Kim, Y., Sharkis, S., Marchionni, L., & Jang, Y. Y. (2011). In vivo liver regeneration potential of human induced pluripotent stem cells from diverse origins. Science Translational Medicine, 3(82), 8239","journal-title":"Science Translational Medicine"},{"issue":"2","key":"10286_CR37","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1002\/hep.27165","volume":"60","author":"N Dianat","year":"2014","unstructured":"Dianat, N., Dubois-Pot-Schneider, H., Steichen, C., Desterke, C., Leclerc, P., Raveux, A., et al. (2014). Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells. Hepatology, 60(2), 700\u2013714","journal-title":"Hepatology"},{"key":"10286_CR38","doi-asserted-by":"publisher","first-page":"368","DOI":"10.3389\/fcell.2019.00368","volume":"7","author":"X Li","year":"2020","unstructured":"Li, X., Chen, R., Kemper, S., & Brigstock, D. R. (2020). Extracellular vesicles from hepatocytes are therapeutic for toxin-mediated fibrosis and gene expression in the liver. Frontiers in Cell and Developmental Biology, 7, 368","journal-title":"Frontiers in Cell and Developmental Biology"},{"issue":"8","key":"10286_CR39","first-page":"E968","volume":"113","author":"J Kowal","year":"2016","unstructured":"Kowal, J., Arras, G., Colombo, M., Jouve, M., Morath, J. P., Primdal-Bengtson, B., et al. (2016). Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes. Proceedings of the National Academy of Sciences of the United States of America, 113(8), E968\u2013E977","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10286_CR40","doi-asserted-by":"crossref","unstructured":"Povero, D., Pinatel, E. M., Leszczynska, A., Goyal, N. P., Nishio, T., Kim, J., et al. (2019). Human induced pluripotent stem cell-derived extracellular vesicles reduce hepatic stellate cell activation and liver fibrosis. JCI Insight, 5(14), e125652","DOI":"10.1172\/jci.insight.125652"},{"issue":"1","key":"10286_CR41","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s13287-017-0595-1","volume":"8","author":"M Rengasamy","year":"2017","unstructured":"Rengasamy, M., Singh, G., Fakharuzi, N. A., Siddikuzzaman, Balasubramanian, S., Swamynathan, P., et al. (2017). Transplantation of human bone marrow mesenchymal stromal cells reduces liver fibrosis more effectively than Wharton\u2019s jelly mesenchymal stromal cells. Stem Cell Research & Therapy, 8(1), 143","journal-title":"Stem Cell Research & Therapy"},{"issue":"1","key":"10286_CR42","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s13287-019-1204-2","volume":"10","author":"X Rong","year":"2019","unstructured":"Rong, X., Liu, J., Yao, X., Jiang, T., Wang, Y., & Xie, F. (2019). Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the Wnt\/\u03b2-catenin pathway. Stem Cell Research & Therapy, 10(1), 98","journal-title":"Stem Cell Research & Therapy"},{"issue":"6","key":"10286_CR43","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1089\/scd.2012.0395","volume":"22","author":"T Li","year":"2013","unstructured":"Li, T., Yan, Y., Wang, B., Qian, H., Zhang, X., Shen, L., et al. (2013). Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis. Stem Cells Dev, 22(6), 845\u2013854","journal-title":"Stem Cells Dev"},{"issue":"23","key":"10286_CR44","doi-asserted-by":"publisher","first-page":"6976","DOI":"10.7150\/thno.35305","volume":"9","author":"Y Zhang","year":"2019","unstructured":"Zhang, Y., Xu, J., Liu, S., Lim, M., Zhao, S., Cui, K., et al. (2019). Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells. Theranostics, 9(23), 6976\u20136990","journal-title":"Theranostics"},{"issue":"41","key":"10286_CR45","doi-asserted-by":"publisher","first-page":"37421","DOI":"10.1021\/acsami.9b10126","volume":"11","author":"S Mardpour","year":"2019","unstructured":"Mardpour, S., Ghanian, M. H., Sadeghi-Abandansari, H., Mardpour, S., Nazari, A., Shekari, F., et al. (2019). Hydrogel-mediated sustained systemic delivery of mesenchymal stem cell-derived extracellular vesicles improves hepatic regeneration in chronic liver failure. ACS Applied Materials & Interfaces, 11(41), 37421\u201337433","journal-title":"ACS Applied Materials & Interfaces"},{"issue":"14","key":"10286_CR46","doi-asserted-by":"publisher","first-page":"12340","DOI":"10.1074\/jbc.M110.194498","volume":"286","author":"RL Pan","year":"2011","unstructured":"Pan, R. L., Wang, P., Xiang, L. X., & Shao, J. Z. (2011). Delta-like 1 serves as a new target and contributor to liver fibrosis down-regulated by mesenchymal stem cell transplantation. The Journal of Biological Chemistry, 286(14), 12340\u201312348","journal-title":"The Journal of Biological Chemistry"},{"issue":"4","key":"10286_CR47","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1002\/hep.26135","volume":"57","author":"CK Huang","year":"2013","unstructured":"Huang, C. K., Lee, S. O., Lai, K. P., Ma, W. L., Lin, T. H., Tsai, M. Y., et al. (2013). Targeting androgen receptor in bone marrow mesenchymal stem cells leads to better transplantation therapy efficacy in liver cirrhosis. Hepatology, 57(4), 1550\u20131563","journal-title":"Hepatology"},{"issue":"5","key":"10286_CR48","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1053\/j.gastro.2016.12.003","volume":"152","author":"SY An","year":"2017","unstructured":"An, S. Y., Jang, Y. J., Lim, H. J., Han, J., Lee, J., Lee, G., et al. (2017). Milk fat globule-EGF factor 8, secreted by mesenchymal stem cells, protects against liver fibrosis in mice. Gastroenterology, 152(5), 1174\u20131186","journal-title":"Gastroenterology"},{"issue":"1","key":"10286_CR49","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/S0016-5085(03)00666-8","volume":"125","author":"S Dooley","year":"2003","unstructured":"Dooley, S., Hamzavi, J., Breitkopf, K., Wiercinska, E., Said, H. M., Lorenzen, J., et al. (2003). Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats. Gastroenterology, 125(1), 178\u2013191","journal-title":"Gastroenterology"},{"issue":"6958","key":"10286_CR50","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nature02006","volume":"425","author":"R Derynck","year":"2003","unstructured":"Derynck, R., & Zhang, Y. E. (2003). Smad-dependent and Smad-independent pathways in TGF-beta family signaling. Nature, 425(6958), 577\u2013584","journal-title":"Nature"},{"issue":"5","key":"10286_CR51","doi-asserted-by":"publisher","first-page":"7227","DOI":"10.3892\/mmr.2015.4362","volume":"12","author":"LT Zhang","year":"2015","unstructured":"Zhang, L. T., Fang, X. Q., Chen, Q. F., Chen, H., Xiao, P., Peng, X. B., et al. (2015). Bone marrow-derived mesenchymal stem cells inhibit the proliferation of hepatic stellate cells by inhibiting the transforming growth factor \u03b2 pathway. Molecular Medicine Reports, 12(5), 7227\u20137232","journal-title":"Molecular Medicine Reports"},{"issue":"10","key":"10286_CR52","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1111\/jcmm.13170","volume":"21","author":"Y Qu","year":"2017","unstructured":"Qu, Y., Zhang, Q., Cai, X., Li, F., Ma, Z., Xu, M., et al. (2017). Exosomes derived from miR-181-5p-modified adipose-derived mesenchymal stem cells prevent liver fibrosis via autophagy activation. Journal of Cellular and Molecular Medicine, 21(10), 2491\u20132502","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"10286_CR53","doi-asserted-by":"publisher","first-page":"30990","DOI":"10.1038\/srep30990","volume":"6","author":"C Contreras-Jurado","year":"2016","unstructured":"Contreras-Jurado, C., Alonso-Merino, E., Saiz-Ladera, C., Vali\u00f1o, A. J., Regadera, J., Alemany, S., et al. (2016). The thyroid hormone receptors inhibit hepatic interleukin-6 signaling during endotoxemia. Scientific Reports, 6, 30990","journal-title":"Scientific Reports"},{"key":"10286_CR54","doi-asserted-by":"crossref","unstructured":"Qiao, H., Zhou, Y., Qin, X., Cheng, J., He, Y., & Jiang, Y. (2018). NADPH oxidase signaling pathway mediates mesenchymal stem cell-induced inhibition of hepatic stellate cell activation.\u00a0Stem Cells International, 2018, 1239143","DOI":"10.1155\/2018\/1239143"},{"issue":"1","key":"10286_CR55","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.bbrc.2008.05.029","volume":"372","author":"N Lin","year":"2008","unstructured":"Lin, N., Tang, Z., Deng, M., Zhong, Y., Lin, J., Yang, X., et al. (2008). Hedgehog-mediated paracrine interaction between hepatic stellate cells and marrow-derived mesenchymal stem cells. Biochemical and Biophysical Research Communications, 372(1), 260\u2013265","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10286_CR56","doi-asserted-by":"crossref","unstructured":"Wang, P. P., Xie, D. Y., Liang, X. J., Peng, L., Zhang, G. L., Ye, Y. N., et al. (2012). HGF and direct mesenchymal stem cells contact synergize to inhibit hepatic stellate cells activation through TLR4\/NF-kB pathway. PLoS One, 7(8), e43408","DOI":"10.1371\/journal.pone.0043408"},{"issue":"4","key":"10286_CR57","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.semcdb.2012.01.009","volume":"23","author":"CR Chillakuri","year":"2012","unstructured":"Chillakuri, C. R., Sheppard, D., Lea, S. M., & Handford, P. A. (2012). Notch receptor-ligand binding and activation: insights from molecular studies. Seminars in Cell & Developmental Biology, 23(4), 421\u2013428","journal-title":"Seminars in Cell & Developmental Biology"},{"issue":"2","key":"10286_CR58","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.ceb.2007.02.012","volume":"19","author":"GD Hurlbut","year":"2007","unstructured":"Hurlbut, G. D., Kankel, M. W., Lake, R. J., & Artavanis-Tsakonas, S. (2007). Crossing paths with Notch in the hyper-network. Current Opinion in Cell Biology, 19(2), 166\u2013175","journal-title":"Current Opinion in Cell Biology"},{"issue":"25\u201326","key":"10286_CR59","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.lfs.2011.10.012","volume":"89","author":"S Chen","year":"2011","unstructured":"Chen, S., Xu, L., Lin, N., Pan, W., Hu, K., & Xu, R. (2011). Activation of Notch1 signaling by marrow-derived mesenchymal stem cells through cell-cell contact inhibits proliferation of hepatic stellate cells. Life Sciences, 89(25\u201326), 975\u2013981.","journal-title":"Life Sciences"},{"issue":"9","key":"10286_CR60","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1016\/j.ajpath.2017.05.005","volume":"187","author":"J Zhang","year":"2017","unstructured":"Zhang, J., Corciulo, C., Liu, H., Wilder, T., Ito, M., & Cronstein, B. (2017). Adenosine A2a receptor blockade diminishes Wnt\/\u03b2-Catenin signaling in a murine model of bleomycin-induced dermal fibrosis. The American Journal of Pathology, 187(9), 1935\u20131944","journal-title":"The American Journal of Pathology"},{"issue":"2","key":"10286_CR61","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1002\/jcp.25897","volume":"233","author":"F Rahmani","year":"2018","unstructured":"Rahmani, F., Avan, A., Hashemy, S. I., & Hassanian, S. M. (2018). Role of Wnt\/\u03b2-catenin signaling regulatory microRNAs in the pathogenesis of colorectal cancer. Journal of Cellular Physiology, 233(2), 811\u2013817","journal-title":"Journal of Cellular Physiology"},{"issue":"6","key":"10286_CR62","doi-asserted-by":"publisher","first-page":"2352","DOI":"10.1002\/hep.29752","volume":"67","author":"J So","year":"2018","unstructured":"So, J., Khaliq, M., Evason, K., Ninov, N., Martin, B. L., Stainier, D. Y. R., et al. (2018). Wnt\/\u03b2-catenin signaling controls intrahepatic biliary network formation in zebrafish by regulating notch activity. Hepatology, 67(6), 2352\u20132366","journal-title":"Hepatology"},{"issue":"16","key":"10286_CR63","doi-asserted-by":"publisher","first-page":"8399","DOI":"10.1074\/jbc.M115.700088","volume":"291","author":"S Nakhaei-Rad","year":"2016","unstructured":"Nakhaei-Rad, S., Nakhaeizadeh, H., G\u00f6tze, S., Kordes, C., Sawitza, I., Hoffmann, M. J., et al. (2016). The role of embryonic stem cell-expressed RAS (ERAS) in the maintenance of quiescent hepatic stellate cells. The Journal of Biological Chemistry, 291(16), 8399\u20138413","journal-title":"The Journal of Biological Chemistry"},{"key":"10286_CR64","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1741-7015-7-41","volume":"7","author":"Z Zhang","year":"2009","unstructured":"Zhang, Z., Zhou, X., Shen, H., Wang, D., & Wang, Y. (2009). Phosphorylated ERK is a potential predictor of sensitivity to sorafenib when treating hepatocellular carcinoma: evidence from an in vitro study. BMC Medicine, 7, 41","journal-title":"BMC Medicine"},{"issue":"2","key":"10286_CR65","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1002\/hep.27387","volume":"61","author":"DA Simonetto","year":"2015","unstructured":"Simonetto, D. A., Yang, H. Y., Yin, M., de Assuncao, T. M., Kwon, J. H., Hilscher, M., et al. (2015). Chronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forces. Hepatology, 61(2), 648\u2013659","journal-title":"Hepatology"},{"issue":"12","key":"10286_CR66","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1136\/gutjnl-2013-306294","volume":"63","author":"J Ehling","year":"2014","unstructured":"Ehling, J., Bartneck, M., Wei, X., Gremse, F., Fech, V., M\u00f6ckel, D., et al. (2014). CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis. Gut, 63(12), 1960\u20131971","journal-title":"Gut"},{"issue":"1","key":"10286_CR67","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1002\/stem.2916","volume":"37","author":"T Yanagawa","year":"2019","unstructured":"Yanagawa, T., Sumiyoshi, H., Higashi, K., Nakao, S., Higashiyama, R., Fukumitsu, H., et al. (2019). Identification of a novel bone marrow cell-derived accelerator of fibrotic liver regeneration through mobilization of hepatic progenitor cells in mice. Stem Cells, 37(1), 89\u2013101","journal-title":"Stem Cells"},{"key":"10286_CR68","doi-asserted-by":"publisher","first-page":"17762","DOI":"10.1038\/srep17762","volume":"5","author":"Y Liu","year":"2015","unstructured":"Liu, Y., Yang, X., Jing, Y., Zhang, S., Zong, C., Jiang, J., et al. (2015). Contribution and mobilization of mesenchymal stem cells in a mouse model of carbon tetrachloride-induced liver fibrosis. Scientific Reports, 5, 17762","journal-title":"Scientific Reports"},{"issue":"5","key":"10286_CR69","first-page":"2545","volume":"41","author":"LT Zhang","year":"2018","unstructured":"Zhang, L. T., Peng, X. B., Fang, X. Q., Li, J. F., Chen, H., & Mao, X. R. (2018). Human umbilical cord mesenchymal stem cells inhibit proliferation of hepatic stellate cells in vitro. International Journal of Molecular Medicine, 41(5), 2545\u20132552","journal-title":"International Journal of Molecular Medicine"},{"issue":"5","key":"10286_CR70","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1053\/j.gastro.2007.02.033","volume":"132","author":"S De Minicis","year":"2007","unstructured":"De Minicis, S., Seki, E., Uchinami, H., Kluwe, J., Zhang, Y., Brenner, D. A., et al. (2007). Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology, 132(5), 1937\u20131946","journal-title":"Gastroenterology"},{"issue":"10","key":"10286_CR71","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/nrm2236","volume":"8","author":"F Pampaloni","year":"2007","unstructured":"Pampaloni, F., Reynaud, E. G., & Stelzer, E. H. (2007). The third dimension bridges the gap between cell culture and live tissue. Nature Reviews. Molecular Cell Biology, 8(10), 839\u2013845","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"10286_CR72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biomaterials.2015.11.026","volume":"78","author":"SB Leite","year":"2016","unstructured":"Leite, S. B., Roosens, T., El Taghdouini, A., Mannaerts, I., Smout, A. J., Najimi, M., et al. (2016). Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro. Biomaterials, 78, 1\u201310","journal-title":"Biomaterials"},{"issue":"6","key":"10286_CR73","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1016\/j.jhep.2013.01.009","volume":"58","author":"P Olinga","year":"2013","unstructured":"Olinga, P., & Schuppan, D. (2013). Precision-cut liver slices: a tool to model the liver ex vivo. Journal of Hepatology, 58(6), 1252\u20131253","journal-title":"Journal of Hepatology"},{"issue":"12","key":"10286_CR74","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/s41422-019-0242-8","volume":"29","author":"S Wang","year":"2019","unstructured":"Wang, S., Wang, X., Tan, Z., Su, Y., Liu, J., Chang, M., et al. (2019). Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury. Cell Research, 29(12), 1009\u20131026","journal-title":"Cell Research"},{"issue":"1","key":"10286_CR75","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.stem.2018.05.027","volume":"23","author":"M Coll","year":"2018","unstructured":"Coll, M., Perea, L., Boon, R., Leite, S. B., Vallverd\u00fa, J., Mannaerts, I., et al. (2018). Generation of hepatic stellate cells from human pluripotent stem cells enables in vitro modeling of liver fibrosis. Cell Stem Cell, 23(1), 101\u20131137","journal-title":"Cell Stem Cell"},{"issue":"5","key":"10286_CR76","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1136\/gutjnl-2014-307979","volume":"65","author":"O Morales-Ibanez","year":"2016","unstructured":"Morales-Ibanez, O., Aff\u00f2, S., Rodrigo-Torres, D., Blaya, D., Mill\u00e1n, C., Coll, M., et al. (2016). Kinase analysis in alcoholic hepatitis identifies p90RSK as a potential mediator of liver fibrogenesis. Gut, 65(5), 840\u2013851","journal-title":"Gut"},{"issue":"3","key":"10286_CR77","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1134\/S0006297919030052","volume":"84","author":"ES Novoseletskaya","year":"2019","unstructured":"Novoseletskaya, E. S., Grigorieva, O. A., Efimenko, A. Y., & Kalinina, N. I. (2019). Extracellular matrix in the regulation of stem cell differentiation. Biochemistry (Mosc), 84(3), 232\u2013240","journal-title":"Biochemistry (Mosc)"},{"issue":"35","key":"10286_CR78","doi-asserted-by":"publisher","first-page":"8995","DOI":"10.1016\/j.biomaterials.2012.08.058","volume":"33","author":"R Ji","year":"2012","unstructured":"Ji, R., Zhang, N., You, N., Li, Q., Liu, W., Jiang, N., et al. (2012). The differentiation of MSCs into functional hepatocyte-like cells in a liver biomatrix scaffold and their transplantation into liver-fibrotic mice. Biomaterials, 33(35), 8995\u20139008","journal-title":"Biomaterials"},{"issue":"2","key":"10286_CR79","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.cld.2013.12.001","volume":"18","author":"Y Iwakiri","year":"2014","unstructured":"Iwakiri, Y. (2014). Pathophysiology of portal hypertension. Clinics in Liver Disease, 18(2), 281\u2013291","journal-title":"Clinics in Liver Disease"},{"issue":"12","key":"10286_CR80","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1016\/j.jcyt.2017.09.006","volume":"19","author":"S Br\u00fcckner","year":"2017","unstructured":"Br\u00fcckner, S., Zipprich, A., Hempel, M., Thonig, A., Schwill, F., Roderfeld, M., et al. (2017). Improvement of portal venous pressure in cirrhotic rat livers by systemic treatment with adipose tissue-derived mesenchymal stromal cells. Cytotherapy, 19(12), 1462\u20131473","journal-title":"Cytotherapy"},{"issue":"4","key":"10286_CR81","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1074\/jbc.275.4.2247","volume":"275","author":"SL Friedman","year":"2000","unstructured":"Friedman, S. L. (2000). Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. The Journal of Biological Chemistry, 275(4), 2247\u20132250","journal-title":"The Journal of Biological Chemistry"},{"issue":"6","key":"10286_CR82","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1002\/hep.28693","volume":"64","author":"KT Suk","year":"2016","unstructured":"Suk, K. T., Yoon, J. H., Kim, M. Y., Kim, C. W., Kim, J. K., Park, H., et al. (2016). Transplantation with autologous bone marrow-derived mesenchymal stem cells for alcoholic cirrhosis: Phase 2 trial. Hepatology, 64(6), 2185\u20132197","journal-title":"Hepatology"},{"issue":"7","key":"10286_CR83","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/nm.2170","volume":"16","author":"BE Uygun","year":"2010","unstructured":"Uygun, B. E., Soto-Gutierrez, A., Yagi, H., Izamis, M. L., Guzzardi, M. A., Shulman, C., et al. (2010). Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nature Medicine, 16(7), 814\u2013820","journal-title":"Nature Medicine"},{"issue":"6","key":"10286_CR84","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1111\/ajt.14666","volume":"18","author":"H Kojima","year":"2018","unstructured":"Kojima, H., Yasuchika, K., Fukumitsu, K., Ishii, T., Ogiso, S., Miyauchi, Y., et al. (2018). Establishment of practical recellularized liver graft for blood perfusion using primary rat hepatocytes and liver sinusoidal endothelial cells. American Journal of Transplantation, 18(6), 1351\u20131359","journal-title":"American Journal of Transplantation"},{"issue":"1","key":"10286_CR85","doi-asserted-by":"publisher","first-page":"5534","DOI":"10.1038\/s41598-017-05134-1","volume":"7","author":"G Mazza","year":"2017","unstructured":"Mazza, G., Al-Akkad, W., Telese, A., Longato, L., Urbani, L., Robinson, B., et al. (2017). Rapid production of human liver scaffolds for functional tissue engineering by high shear stress oscillation-decellularization. Scientific Reports, 7(1), 5534","journal-title":"Scientific Reports"},{"issue":"1","key":"10286_CR86","doi-asserted-by":"publisher","first-page":"015014","DOI":"10.1088\/1758-5090\/9\/1\/015014","volume":"9","author":"AA Banaeiyan","year":"2017","unstructured":"Banaeiyan, A. A., Theobald, J., Pauk\u0161tyte, J., W\u00f6lfl, S., Adiels, C. B., & Goks\u00f6r, M. (2017). Design and fabrication of a scalable liver-lobule-on-a-chip microphysiological platform. Biofabrication, 9(1), 015014","journal-title":"Biofabrication"},{"issue":"1","key":"10286_CR87","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s13287-016-0371-7","volume":"7","author":"MH Yen","year":"2016","unstructured":"Yen, M. H., Wu, Y. Y., Liu, Y. S., Rimando, M., Ho, J. H., & Lee, O. K. (2016). Efficient generation of hepatic cells from mesenchymal stromal cells by an innovative bio-microfluidic cell culture device. Stem Cell Research & Therapy, 7(1), 120","journal-title":"Stem Cell Research & Therapy"},{"issue":"1","key":"10286_CR88","doi-asserted-by":"publisher","first-page":"16005","DOI":"10.1038\/s41598-018-34351-5","volume":"8","author":"D Van der Helm","year":"2018","unstructured":"Van der Helm, D., Groenewoud, A., de Jonge-Muller, E. S. M., Barnhoorn, M. C., Schoonderwoerd, M. J. A., Coenraad, M. J., et al. (2018). Mesenchymal stromal cells prevent progression of liver fibrosis in a novel zebrafish embryo model. Scientific Reports, 8(1), 16005","journal-title":"Scientific Reports"},{"issue":"25","key":"10286_CR89","doi-asserted-by":"publisher","first-page":"3086","DOI":"10.3748\/wjg.15.3086","volume":"15","author":"MJ Tu\u00f1\u00f3n","year":"2009","unstructured":"Tu\u00f1\u00f3n, M. J., Alvarez, M., Culebras, J. M., & Gonz\u00e1lez-Gallego, J. (2009). An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure. World Journal of Gastroenterology, 15(25), 3086\u20133098","journal-title":"World Journal of Gastroenterology"},{"issue":"11","key":"10286_CR90","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1136\/gutjnl-2018-316091","volume":"68","author":"L Yuan","year":"2019","unstructured":"Yuan, L., Jiang, J., Liu, X., Zhang, Y., Zhang, L., Xin, J., et al. (2019). HBV infection-induced liver cirrhosis development in dual-humanised mice with human bone mesenchymal stem cell transplantation. Gut, 68(11), 2044\u20132056","journal-title":"Gut"},{"issue":"6","key":"10286_CR91","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1053\/j.gastro.2015.08.034","volume":"149","author":"W Goessling","year":"2015","unstructured":"Goessling, W., & Sadler, K. C. (2015). Zebrafish: an important tool for liver disease research. Gastroenterology, 149(6), 1361\u20131377","journal-title":"Gastroenterology"},{"issue":"1","key":"10286_CR92","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/liv.12218","volume":"34","author":"YO Jang","year":"2014","unstructured":"Jang, Y. O., Kim, Y. J., Baik, S. K., Kim, M. Y., Eom, Y. W., Cho, M. Y., et al. (2014). Histological improvement following administration of autologous bone marrow-derived mesenchymal stem cells for alcoholic cirrhosis: a pilot study. Liver International, 34(1), 33\u201341","journal-title":"Liver International"},{"issue":"12","key":"10286_CR93","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.dld.2015.08.018","volume":"47","author":"P Andreone","year":"2015","unstructured":"Andreone, P., Catani, L., Margini, C., Brodosi, L., Lorenzini, S., Sollazzo, D., et al. (2015). Reinfusion of highly purified CD133+ bone marrow-derived stem\/progenitor cells in patients with end-stage liver disease: A phase I clinical trial. Digestive and Liver Disease, 47(12), 1059\u20131066","journal-title":"Digestive and Liver Disease"},{"issue":"1","key":"10286_CR94","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s13287-015-0106-1","volume":"6","author":"AR Zekri","year":"2015","unstructured":"Zekri, A. R., Salama, H., Medhat, E., Musa, S., Abdel-Haleem, H., Ahmed, O. S., et al. (2015). The impact of repeated autologous infusion of haematopoietic stem cells in patients with liver insufficiency. Stem Cell Research & Therapy, 6(1), 118","journal-title":"Stem Cell Research & Therapy"},{"issue":"3","key":"10286_CR95","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1053\/j.gastro.2011.11.027","volume":"142","author":"V Garg","year":"2012","unstructured":"Garg, V., Garg, H., Khan, A., Trehanpati, N., Kumar, A., Sharma, B. C., et al. (2012). Granulocyte colony-stimulating factor mobilizes CD34(+) cells and improves survival of patients with acute-on-chronic liver failure. Gastroenterology, 142(3), 505\u20135121","journal-title":"Gastroenterology"},{"issue":"10","key":"10286_CR96","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1111\/liv.12228","volume":"33","author":"M Mohamadnejad","year":"2013","unstructured":"Mohamadnejad, M., Alimoghaddam, K., Bagheri, M., Ashrafi, M., Abdollahzadeh, L., Akhlaghpoor, S., et al. (2013). Randomized placebo-controlled trial of mesenchymal stem cell transplantation in decompensated cirrhosis. Liver International, 33(10), 1490\u20131496","journal-title":"Liver International"},{"issue":"1","key":"10286_CR97","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s13287-017-0541-2","volume":"8","author":"N Lanthier","year":"2017","unstructured":"Lanthier, N., Lin-Marq, N., Rubbia-Brandt, L., Cl\u00e9ment, S., Goossens, N., & Spahr, L. (2017). Autologous bone marrow-derived cell transplantation in decompensated alcoholic liver disease: what is the impact on liver histology and gene expression patterns? Stem Cell Research & Therapy, 8(1), 88","journal-title":"Stem Cell Research & Therapy"},{"key":"10286_CR98","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1756-8722-5-19","volume":"5","author":"S Wang","year":"2012","unstructured":"Wang, S., Qu, X., & Zhao, R. C. (2012). Clinical applications of mesenchymal stem cells. Journal of Hematology & Oncology, 5, 19","journal-title":"Journal of Hematology & Oncology"},{"issue":"9","key":"10286_CR99","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1111\/1756-185X.13015","volume":"20","author":"J Liang","year":"2017","unstructured":"Liang, J., Zhang, H., Zhao, C., Wang, D., Ma, X., Zhao, S., et al. (2017). Effects of allogeneic mesenchymal stem cell transplantation in the treatment of liver cirrhosis caused by autoimmune diseases. International Journal of Rheumatic Diseases, 20(9), 1219\u20131226","journal-title":"International Journal of Rheumatic Diseases"},{"issue":"1","key":"10286_CR100","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jhep.2017.03.001","volume":"67","author":"O Detry","year":"2017","unstructured":"Detry, O., Vandermeulen, M., Delbouille, M. H., Somja, J., Bletard, N., Briquet, A., et al. (2017). Infusion of mesenchymal stromal cells after deceased liver transplantation: A phase I-II, open-label, clinical study. Journal of Hepatology, 67(1), 47\u201355","journal-title":"Journal of Hepatology"},{"issue":"2","key":"10286_CR101","doi-asserted-by":"publisher","first-page":"386","DOI":"10.3390\/cells9020386","volume":"9","author":"V Cernigliaro","year":"2020","unstructured":"Cernigliaro, V., Peluso, R., Zedda, B., Silengo, L., Tolosano, E., Pellicano, R., et al. (2020). Evolving cell-based and cell-free clinical strategies for treating severe human liver diseases. Cells, 9(2), 386","journal-title":"Cells"},{"issue":"11","key":"10286_CR102","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.3748\/wjg.v23.i11.1974","volume":"23","author":"R Sakiyama","year":"2017","unstructured":"Sakiyama, R., Blau, B. J., & Miki, T. (2017). Clinical translation of bioartificial liver support systems with human pluripotent stem cell-derived hepatic cells. World Journal of Gastroenterology, 23(11), 1974\u20131979","journal-title":"World Journal of Gastroenterology"},{"issue":"3","key":"10286_CR103","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1097\/MOG.0000000000000724","volume":"37","author":"YW Eom","year":"2021","unstructured":"Eom, Y. W., Yoon, Y., & Baik, S. K. (2021). Mesenchymal stem cell therapy for liver disease: current status and future perspectives. Current Opinion in Gastroenterology, 37(3), 216\u2013223","journal-title":"Current Opinion in Gastroenterology"},{"key":"10286_CR104","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s13578-020-00480-6","volume":"10","author":"X Yang","year":"2020","unstructured":"Yang, X., Meng, Y., Han, Z., Ye, F., Wei, L., & Zong, C. (2020). Mesenchymal stem cell therapy for liver disease: full of chances and challenges. Cell & Bioscience, 10, 123","journal-title":"Cell & Bioscience"}],"container-title":["Stem Cell Reviews and Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-021-10286-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12015-021-10286-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-021-10286-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T01:01:57Z","timestamp":1675818117000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12015-021-10286-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,19]]},"references-count":104,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10286"],"URL":"https:\/\/doi.org\/10.1007\/s12015-021-10286-9","relation":{},"ISSN":["2629-3269","2629-3277"],"issn-type":[{"value":"2629-3269","type":"print"},{"value":"2629-3277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,19]]},"assertion":[{"value":"14 October 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no conflicts of interest.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}