{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T03:14:44Z","timestamp":1794107684790,"version":"4.8.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:00:00Z","timestamp":1661472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:00:00Z","timestamp":1661472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Rev and Rep"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1007\/s12015-022-10447-4","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T01:02:42Z","timestamp":1661475762000},"page":"67-75","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Role of PHF6 in Hematopoiesis and Hematologic Malignancies"],"prefix":"10.1007","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1159-8768","authenticated-orcid":false,"given":"Yusra A.","family":"Eisa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8524-4095","authenticated-orcid":false,"given":"Feng-Chun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,26]]},"reference":[{"issue":"4","key":"10447_CR1","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/ng1040","volume":"32","author":"KM Lower","year":"2002","unstructured":"Lower, K. M., Turner, G., Kerr, B. A., et al. (2002). Mutations in PHF6 are associated with B\u00f6rjeson-Forssman-Lehmann syndrome. Nature Genetics, 32(4), 661\u2013665. https:\/\/doi.org\/10.1038\/ng1040","journal-title":"Nature Genetics"},{"issue":"10","key":"10447_CR2","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1136\/jmg.2004.020370","volume":"41","author":"D Vall\u00e9e","year":"2004","unstructured":"Vall\u00e9e, D., Chevrier, E., Graham, G. E., et al. (2004). A novel PHF6 mutation results in enhanced exon skipping and mild B\u00f6rjeson-Forssman-Lehmann syndrome. Journal of Medical Genetics, 41(10), 778\u2013783. https:\/\/doi.org\/10.1136\/jmg.2004.020370","journal-title":"Journal of Medical Genetics"},{"issue":"8","key":"10447_CR3","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1016\/j.modgep.2007.06.007","volume":"7","author":"AK Voss","year":"2007","unstructured":"Voss, A. K., Gamble, R., Collin, C., et al. (2007). Protein and gene expression analysis of Phf6, the gene mutated in the B\u00f6rjeson-Forssman-Lehmann Syndrome of intellectual disability and obesity. Gene Expression Patterns, 7(8), 858\u2013871. https:\/\/doi.org\/10.1016\/j.modgep.2007.06.007","journal-title":"Gene Expression Patterns"},{"issue":"8","key":"10447_CR4","doi-asserted-by":"publisher","first-page":"4326","DOI":"10.1021\/pr3004369","volume":"11","author":"MA Todd","year":"2012","unstructured":"Todd, M. A., & Picketts, D. J. (2012). PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex. Journal of Proteome Research, 11(8), 4326\u20134337. https:\/\/doi.org\/10.1021\/pr3004369","journal-title":"Journal of Proteome Research"},{"key":"10447_CR5","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1471-2164-7-6","volume":"7","author":"J Perry","year":"2006","unstructured":"Perry, J. (2006). The Epc-N domain: A predicted protein-protein interaction domain found in select chromatin associated proteins. BMC Genomics, 7, 6. https:\/\/doi.org\/10.1186\/1471-2164-7-6","journal-title":"BMC Genomics"},{"key":"10447_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.704471","volume":"11","author":"JH Kurzer","year":"2021","unstructured":"Kurzer, J. H., & Weinberg, O. K. (2021). PHF6 Mutations in Hematologic Malignancies. Frontiers in Oncology, 11, 704471. https:\/\/doi.org\/10.3389\/fonc.2021.704471","journal-title":"Frontiers in Oncology"},{"issue":"4","key":"10447_CR7","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1002\/gcc.22039","volume":"52","author":"V Grossmann","year":"2013","unstructured":"Grossmann, V., Haferlach, C., Weissmann, S., et al. (2013). The molecular profile of adult T-cell acute lymphoblastic leukemia: Mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL. Genes, Chromosomes & Cancer, 52(4), 410\u2013422. https:\/\/doi.org\/10.1002\/gcc.22039","journal-title":"Genes, Chromosomes & Cancer"},{"issue":"4","key":"10447_CR8","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/ng.542","volume":"42","author":"P Van Vlierberghe","year":"2010","unstructured":"Van Vlierberghe, P., Palomero, T., Khiabanian, H., et al. (2010). PHF6 mutations in T-cell acute lymphoblastic leukemia. Nature Genetics, 42(4), 338\u2013342. https:\/\/doi.org\/10.1038\/ng.542","journal-title":"Nature Genetics"},{"key":"10447_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.599472","volume":"8","author":"S Loontiens","year":"2020","unstructured":"Loontiens, S., Dolens, A. C., Strubbe, S., et al. (2020). PHF6 Expression Levels Impact Human Hematopoietic Stem Cell Differentiation.\u00a0Frontiers in Cellular\u00a0Developmental Biology, 8, 599472. https:\/\/doi.org\/10.3389\/fcell.2020.599472","journal-title":"Front Cell Dev Biol."},{"issue":"6","key":"10447_CR10","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.jpeds.2004.07.041","volume":"145","author":"J Visootsak","year":"2004","unstructured":"Visootsak, J., Rosner, B., Dykens, E., et al. (2004). Clinical and behavioral features of patients with Borjeson-Forssman-Lehmann syndrome with mutations in PHF6. Journal of Pediatrics, 145(6), 819\u2013825. https:\/\/doi.org\/10.1016\/j.jpeds.2004.07.041","journal-title":"Journal of Pediatrics"},{"issue":"10","key":"10447_CR11","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1101\/gad.295857.117","volume":"31","author":"YM Soto-Feliciano","year":"2017","unstructured":"Soto-Feliciano, Y. M., Bartlebaugh, J. M. E., Liu, Y., et al. (2017). PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes. Genes & Development, 31(10), 973\u2013989. https:\/\/doi.org\/10.1101\/gad.295857.117","journal-title":"Genes & Development"},{"issue":"14","key":"10447_CR12","doi-asserted-by":"publisher","first-page":"10069","DOI":"10.1074\/jbc.M113.535351","volume":"289","author":"Z Liu","year":"2014","unstructured":"Liu, Z., Li, F., Ruan, K., et al. (2014). Structural and functional insights into the human B\u00f6rjeson-Forssman-Lehmann syndrome-associated protein PHF6. Journal of Biological Chemistry, 289(14), 10069\u201310083. https:\/\/doi.org\/10.1074\/jbc.M113.535351","journal-title":"Journal of Biological Chemistry"},{"issue":"6","key":"10447_CR13","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/s1097-2765(00)80299-3","volume":"2","author":"Y Xue","year":"1998","unstructured":"Xue, Y., Wong, J., Moreno, G. T., Young, M. K., C\u00f4t\u00e9, J., & Wang, W. (1998). NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Molecular Cell, 2(6), 851\u2013861. https:\/\/doi.org\/10.1016\/s1097-2765(00)80299-3","journal-title":"Molecular Cell"},{"issue":"9","key":"10447_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024515","volume":"6","author":"RC Potts","year":"2011","unstructured":"Potts, R. C., Zhang, P., Wurster, A. L., et al. (2011). CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes. PLoS One, 6(9), e24515. https:\/\/doi.org\/10.1371\/journal.pone.0024515","journal-title":"PLoS ONE"},{"issue":"9","key":"10447_CR15","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1101\/gad.1642808","volume":"22","author":"T Yoshida","year":"2008","unstructured":"Yoshida, T., Hazan, I., Zhang, J., et al. (2008). The role of the chromatin remodeler Mi-2beta in hematopoietic stem cell self-renewal and multilineage differentiation. Genes & Development, 22(9), 1174\u20131189. https:\/\/doi.org\/10.1101\/gad.1642808","journal-title":"Genes & Development"},{"issue":"7098","key":"10447_CR16","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/nature04835","volume":"442","author":"X Shi","year":"2006","unstructured":"Shi, X., Hong, T., Walter, K. L., et al. (2006). ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature, 442(7098), 96\u201399. https:\/\/doi.org\/10.1038\/nature04835","journal-title":"Nature"},{"issue":"16","key":"10447_CR17","doi-asserted-by":"publisher","first-page":"9037","DOI":"10.1093\/nar\/gkaa626","volume":"48","author":"S Oh","year":"2020","unstructured":"Oh, S., Boo, K., Kim, J., et al. (2020). The chromatin-binding protein PHF6 functions as an E3 ubiquitin ligase of H2BK120 via H2BK12Ac recognition for activation of trophectodermal genes. Nucleic Acids Research, 48(16), 9037\u20139052. https:\/\/doi.org\/10.1093\/nar\/gkaa626","journal-title":"Nucleic Acids Research"},{"issue":"5","key":"10447_CR18","doi-asserted-by":"publisher","first-page":"3174","DOI":"10.1074\/jbc.M112.414839","volume":"288","author":"J Wang","year":"2013","unstructured":"Wang, J., Leung, J. W., Gong, Z., Feng, L., Shi, X., & Chen, J. (2013). PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis. Journal of Biological Chemistry, 288(5), 3174\u20133183. https:\/\/doi.org\/10.1074\/jbc.M112.414839","journal-title":"Journal of Biological Chemistry"},{"issue":"6","key":"10447_CR19","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.neuron.2013.04.021","volume":"78","author":"C Zhang","year":"2013","unstructured":"Zhang, C., Mejia, L. A., Huang, J., et al. (2013). The X-linked intellectual disability protein PHF6 associates with the PAF1 complex and regulates neuronal migration in the mammalian brain. Neuron, 78(6), 986\u2013993. https:\/\/doi.org\/10.1016\/j.neuron.2013.04.021","journal-title":"Neuron"},{"issue":"1","key":"10447_CR20","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201948460","volume":"21","author":"DO Warmerdam","year":"2020","unstructured":"Warmerdam, D. O., Alonso-de Vega, I., Wiegant, W. W., et al. (2020). PHF6 promotes non-homologous end joining and G2 checkpoint recovery. EMBO Reports, 21(1), e48460. https:\/\/doi.org\/10.15252\/embr.201948460","journal-title":"EMBO Reports"},{"issue":"3","key":"10447_CR21","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1111\/j.0009-9163.2004.00215.x","volume":"65","author":"G Turner","year":"2004","unstructured":"Turner, G., Lower, K. M., White, S. M., et al. (2004). The clinical picture of the B\u00f6rjeson-Forssman-Lehmann syndrome in males and heterozygous females with PHF6 mutations. Clinical Genetics, 65(3), 226\u2013232. https:\/\/doi.org\/10.1111\/j.0009-9163.2004.00215.x","journal-title":"Clinical Genetics"},{"key":"10447_CR22","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.0954-6820.1962.tb04162.x","volume":"171","author":"M Borjeson","year":"1962","unstructured":"Borjeson, M., Forssman, H., & Lehmann, O. (1962). An X-linked, recessively inherited syndrome characterized by grave mental deficiency, epilepsy, and endocrine disorder. Acta Medica Scandinavica, 171, 13\u201321. https:\/\/doi.org\/10.1111\/j.0954-6820.1962.tb04162.x","journal-title":"Acta Medica Scandinavica"},{"issue":"12","key":"10447_CR23","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1038\/sj.ejhg.5201639","volume":"14","author":"J G\u00e9cz","year":"2006","unstructured":"G\u00e9cz, J., Turner, G., Nelson, J., & Partington, M. (2006). The B\u00f6rjeson-Forssman-Lehman syndrome (BFLS, MIM #301900). European Journal of Human Genetics, 14(12), 1233\u20131237. https:\/\/doi.org\/10.1038\/sj.ejhg.5201639","journal-title":"European Journal of Human Genetics"},{"issue":"2","key":"10447_CR24","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3390\/genes6020325","volume":"6","author":"MA Todd","year":"2015","unstructured":"Todd, M. A., Ivanochko, D., & Picketts, D. J. (2015). PHF6 Degrees of Separation: The Multifaceted Roles of a Chromatin Adaptor Protein. Genes (Basel), 6(2), 325\u2013352. https:\/\/doi.org\/10.3390\/genes6020325","journal-title":"Genes (Basel)."},{"key":"10447_CR25","doi-asserted-by":"publisher","DOI":"10.1159\/000330111","author":"S Berland","year":"2011","unstructured":"Berland, S. (2011). PHF6 deletions may cause borjeson-forssman-lehmann syndrome in females. Molecular Syndromology. https:\/\/doi.org\/10.1159\/000330111","journal-title":"Molecular Syndromology."},{"key":"10447_CR26","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32624","author":"C Mt","year":"2009","unstructured":"Mt, C. (2009). Further clinical delineation of the B\u00f6rjeson\u2013Forssman\u2013Lehmann syndrome in patients with PHF6 mutations. American Journal of Medical Genetics. https:\/\/doi.org\/10.1002\/ajmg.a.32624","journal-title":"American Journal of Medical Genetics"},{"issue":"3","key":"10447_CR27","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1136\/jmg.2005.033084","volume":"43","author":"J Crawford","year":"2006","unstructured":"Crawford, J., Lower, K. M., Hennekam, R. C., et al. (2006). Mutation screening in Borjeson-Forssman-Lehmann syndrome: Identification of a novel de novo PHF6 mutation in a female patient. Journal of Medical Genetics, 43(3), 238\u2013243. https:\/\/doi.org\/10.1136\/jmg.2005.033084","journal-title":"Journal of Medical Genetics"},{"issue":"12","key":"10447_CR28","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1136\/jmedgenet-2013-101918","volume":"50","author":"C Zweier","year":"2013","unstructured":"Zweier, C., Kraus, C., Brueton, L., et al. (2013). A new face of Borjeson-Forssman-Lehmann syndrome? De novo mutations in PHF6 in seven females with a distinct phenotype. Journal of Medical Genetics, 50(12), 838\u2013847. https:\/\/doi.org\/10.1136\/jmedgenet-2013-101918","journal-title":"Journal of Medical Genetics"},{"issue":"6","key":"10447_CR29","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1016\/j.celrep.2018.10.043","volume":"25","author":"C Cheng","year":"2018","unstructured":"Cheng, C., Deng, P. Y., Ikeuchi, Y., et al. (2018). Characterization of a Mouse Model of B\u00f6rjeson-Forssman-Lehmann Syndrome. Cell Reports, 25(6), 1404-1414.e6. https:\/\/doi.org\/10.1016\/j.celrep.2018.10.043","journal-title":"Cell Reports"},{"key":"10447_CR30","doi-asserted-by":"publisher","unstructured":"McRae, H. M., Eccles, S., Whitehead, L., et al. (2020). Downregulation of the GHRH\/GH\/IGF1 axis in a mouse model of B\u00f6rjeson-Forssman-Lehman syndrome. Development, 147(21). https:\/\/doi.org\/10.1242\/dev.187021","DOI":"10.1242\/dev.187021"},{"issue":"1","key":"10447_CR31","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/s1535-6108(02)00018-1","volume":"1","author":"AA Ferrando","year":"2002","unstructured":"Ferrando, A. A., Neuberg, D. S., Staunton, J., et al. (2002). Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell, 1(1), 75\u201387. https:\/\/doi.org\/10.1016\/s1535-6108(02)00018-1","journal-title":"Cancer Cell"},{"issue":"3","key":"10447_CR32","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1158\/2159-8290.Cd-18-1005","volume":"9","author":"AA Wendorff","year":"2019","unstructured":"Wendorff, A. A., Quinn, S. A., Rashkovan, M., et al. (2019). Phf6 Loss Enhances HSC Self-Renewal Driving Tumor Initiation and Leukemia Stem Cell Activity in T-ALL. Cancer Discovery, 9(3), 436\u2013451. https:\/\/doi.org\/10.1158\/2159-8290.Cd-18-1005","journal-title":"Cancer Discovery"},{"issue":"7","key":"10447_CR33","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1093\/hmg\/ddab081","volume":"30","author":"R Ahmed","year":"2021","unstructured":"Ahmed, R., Sarwar, S., Hu, J., et al. (2021). Transgenic mice with an R342X mutation in Phf6 display clinical features of B\u00f6rjeson-Forssman-Lehmann Syndrome. Human Molecular Genetics, 30(7), 575\u2013594. https:\/\/doi.org\/10.1093\/hmg\/ddab081","journal-title":"Human Molecular Genetics"},{"issue":"2","key":"10447_CR34","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1182\/blood.V91.2.419","volume":"91","author":"S Ogilvy","year":"1998","unstructured":"Ogilvy, S., Elefanty, A. G., Visvader, J., Bath, M. L., Harris, A. W., & Adams, J. M. (1998). Transcriptional regulation of vav, a gene expressed throughout the hematopoietic compartment. Blood, 91(2), 419\u2013430.","journal-title":"Blood"},{"issue":"1","key":"10447_CR35","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/leu.2010.247","volume":"25","author":"P Van Vlierberghe","year":"2011","unstructured":"Van Vlierberghe, P., Patel, J., Abdel-Wahab, O., et al. (2011). PHF6 mutations in adult acute myeloid leukemia. Leukemia, 25(1), 130\u2013134. https:\/\/doi.org\/10.1038\/leu.2010.247","journal-title":"Leukemia"},{"key":"10447_CR36","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13045-015-0138-0","volume":"8","author":"K Karrman","year":"2015","unstructured":"Karrman, K., Castor, A., Behrendtz, M., et al. (2015). Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A. Journal of Hematology & Oncology, 8, 42. https:\/\/doi.org\/10.1186\/s13045-015-0138-0","journal-title":"Journal of Hematology & Oncology."},{"issue":"1","key":"10447_CR37","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3109\/0284186x.2011.592148","volume":"51","author":"NJ Yoo","year":"2012","unstructured":"Yoo, N. J., Kim, Y. R., & Lee, S. H. (2012). Somatic mutation of PHF6 gene in T-cell acute lymphoblatic leukemia, acute myelogenous leukemia and hepatocellular carcinoma. Acta Oncologica, 51(1), 107\u2013111. https:\/\/doi.org\/10.3109\/0284186x.2011.592148","journal-title":"Acta Oncologica"},{"issue":"40","key":"10447_CR38","doi-asserted-by":"publisher","first-page":"65485","DOI":"10.18632\/oncotarget.11796","volume":"7","author":"JF Spinella","year":"2016","unstructured":"Spinella, J. F., Cassart, P., Richer, C., et al. (2016). Genomic characterization of pediatric T-cell acute lymphoblastic leukemia reveals novel recurrent driver mutations. Oncotarget, 7(40), 65485\u201365503. https:\/\/doi.org\/10.18632\/oncotarget.11796","journal-title":"Oncotarget"},{"issue":"12","key":"10447_CR39","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.3324\/haematol.2011.043083","volume":"96","author":"Q Wang","year":"2011","unstructured":"Wang, Q., Qiu, H., Jiang, H., et al. (2011). Mutations of PHF6 are associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214 in T-cell acute lymphoblastic leukemia. Haematologica, 96(12), 1808\u20131814. https:\/\/doi.org\/10.3324\/haematol.2011.043083","journal-title":"Haematologica"},{"issue":"7727","key":"10447_CR40","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/s41586-018-0436-0","volume":"562","author":"TB Alexander","year":"2018","unstructured":"Alexander, T. B., Gu, Z., Iacobucci, I., et al. (2018). The genetic basis and cell of origin of mixed phenotype acute leukaemia. Nature, 562(7727), 373\u2013379. https:\/\/doi.org\/10.1038\/s41586-018-0436-0","journal-title":"Nature"},{"issue":"23","key":"10447_CR41","doi-asserted-by":"publisher","first-page":"3526","DOI":"10.1182\/bloodadvances.2018023531","volume":"2","author":"W Xiao","year":"2018","unstructured":"Xiao, W., Bharadwaj, M., Levine, M., et al. (2018). PHF6 and DNMT3A mutations are enriched in distinct subgroups of mixed phenotype acute leukemia with T-lineage differentiation. Blood Advances, 2(23), 3526\u20133539. https:\/\/doi.org\/10.1182\/bloodadvances.2018023531","journal-title":"Blood Advances"},{"issue":"11","key":"10447_CR42","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1002\/ajh.25256","volume":"93","author":"X Mi","year":"2018","unstructured":"Mi, X., Griffin, G., Lee, W., et al. (2018). Genomic and clinical characterization of B\/T mixed phenotype acute leukemia reveals recurrent features and T-ALL like mutations. American Journal of Hematology, 93(11), 1358\u20131367. https:\/\/doi.org\/10.1002\/ajh.25256","journal-title":"American Journal of Hematology"},{"issue":"11","key":"10447_CR43","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1038\/leu.2016.212","volume":"30","author":"T Mori","year":"2016","unstructured":"Mori, T., Nagata, Y., Makishima, H., et al. (2016). Somatic PHF6 mutations in 1760 cases with various myeloid neoplasms. Leukemia, 30(11), 2270\u20132273. https:\/\/doi.org\/10.1038\/leu.2016.212","journal-title":"Leukemia"},{"issue":"Supplement 1","key":"10447_CR44","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1182\/blood.V130.Suppl_1.1384.1384","volume":"130","author":"W Xiao","year":"2017","unstructured":"Xiao, W., Pastore, F., Getta, B., et al. (2017). PHF6 Mutations Defines a Subgroup of Mixed Phenotype of Acute Leukemia with Aberrant T-Cell Differentiation. Blood, 130(Supplement 1), 1384\u20131384. https:\/\/doi.org\/10.1182\/blood.V130.Suppl_1.1384.1384","journal-title":"Blood"},{"issue":"5","key":"10447_CR45","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1111\/bjh.13891","volume":"175","author":"JD de Rooij","year":"2016","unstructured":"de Rooij, J. D., van den Heuvel-Eibrink, M. M., van de Rijdt, N. K., et al. (2016). PHF6 mutations in paediatric acute myeloid leukaemia. British Journal of Haematology, 175(5), 967\u2013971. https:\/\/doi.org\/10.1111\/bjh.13891","journal-title":"British Journal of Haematology"},{"issue":"3","key":"10447_CR46","doi-asserted-by":"publisher","first-page":"671","DOI":"10.3109\/10428194.2012.725203","volume":"54","author":"X Li","year":"2013","unstructured":"Li, X., Yao, H., Chen, Z., Wang, Q., Zhao, Y., & Chen, S. (2013). Somatic mutations of PHF6 in patients with chronic myeloid leukemia in blast crisis. Leukaemia & Lymphoma, 54(3), 671\u2013672. https:\/\/doi.org\/10.3109\/10428194.2012.725203","journal-title":"Leukaemia & Lymphoma"},{"issue":"5","key":"10447_CR47","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s00277-012-1664-2","volume":"92","author":"HJ Huh","year":"2013","unstructured":"Huh, H. J., Lee, S. H., Yoo, K. H., et al. (2013). Gene mutation profiles and prognostic implications in Korean patients with T-lymphoblastic leukemia. Annals of Hematology, 92(5), 635\u2013644. https:\/\/doi.org\/10.1007\/s00277-012-1664-2","journal-title":"Annals of Hematology"},{"issue":"Supplement 1","key":"10447_CR48","doi-asserted-by":"publisher","first-page":"4001","DOI":"10.1182\/blood.V130.Suppl_1.4001.4001","volume":"130","author":"A Stengel","year":"2017","unstructured":"Stengel, A., Kern, W., Meggendorfer, M., Haferlach, T., & Haferlach, C. (2017). High Grade B Cell Lymphoma with MYC and BCL2 and\/or BCL6 Rearrangements Depict a High Complexity on the Cytogenetic, but Not on the Molecular Genetic Level and Show MYC Mutations As Prognostic Marker. Blood, 130(Supplement 1), 4001\u20134001. https:\/\/doi.org\/10.1182\/blood.V130.Suppl_1.4001.4001","journal-title":"Blood"},{"issue":"20","key":"10447_CR49","doi-asserted-by":"publisher","first-page":"5165","DOI":"10.1182\/bloodadvances.2019001307","volume":"4","author":"H Ueno","year":"2020","unstructured":"Ueno, H., Yoshida, K., Shiozawa, Y., et al. (2020). Landscape of driver mutations and their clinical impacts in pediatric B-cell precursor acute lymphoblastic leukemia. Blood Advances, 4(20), 5165\u20135173. https:\/\/doi.org\/10.1182\/bloodadvances.2019001307","journal-title":"Blood Advances"},{"issue":"11","key":"10447_CR50","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1038\/leu.2010.202","volume":"24","author":"OK Weinberg","year":"2010","unstructured":"Weinberg, O. K., & Arber, D. A. (2010). Mixed-phenotype acute leukemia: Historical overview and a new definition. Leukemia, 24(11), 1844\u20131851. https:\/\/doi.org\/10.1038\/leu.2010.202","journal-title":"Leukemia"},{"issue":"8","key":"10447_CR51","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.exphem.2016.05.003","volume":"44","author":"OS Eckstein","year":"2016","unstructured":"Eckstein, O. S., Wang, L., Punia, J. N., et al. (2016). Mixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes. Experimental Hematology, 44(8), 740\u2013744. https:\/\/doi.org\/10.1016\/j.exphem.2016.05.003","journal-title":"Experimental Hematology"},{"issue":"7","key":"10447_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2016.50","volume":"6","author":"I De Kouchkovsky","year":"2016","unstructured":"De Kouchkovsky, I., & Abdul-Hay, M. (2016). Acute myeloid leukemia: A comprehensive review and 2016 update. Blood Cancer Journal, 6(7), e441. https:\/\/doi.org\/10.1038\/bcj.2016.50","journal-title":"Blood Cancer Journal"},{"issue":"Suppl 2","key":"10447_CR53","doi-asserted-by":"publisher","first-page":"S107","DOI":"10.1007\/s00277-015-2325-z","volume":"94","author":"B Chereda","year":"2015","unstructured":"Chereda, B., & Melo, J. V. (2015). Natural course and biology of CML. Annals of Hematology, 94(Suppl 2), S107\u2013S121. https:\/\/doi.org\/10.1007\/s00277-015-2325-z","journal-title":"Annals of Hematology"},{"issue":"4","key":"10447_CR54","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1089\/cbr.2018.2671","volume":"34","author":"Q Yu","year":"2019","unstructured":"Yu, Q., Yin, L., Jian, Y., Li, P., Zeng, W., & Zhou, J. (2019). Downregulation of PHF6 Inhibits Cell Proliferation and Migration in Hepatocellular Carcinoma. Cancer Biotherapy & Radiopharmaceuticals, 34(4), 245\u2013251. https:\/\/doi.org\/10.1089\/cbr.2018.2671","journal-title":"Cancer Biotherapy & Radiopharmaceuticals"},{"key":"10447_CR55","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4250-0","author":"M Hajjari","year":"2015","unstructured":"Hajjari, M. (2015). The potential role of PHF6 as an oncogene: A genotranscriptomic\/proteomic meta-analysis. Tumor Biology. https:\/\/doi.org\/10.1007\/s13277-015-4250-0","journal-title":"Tumor Biology."},{"issue":"12","key":"10447_CR56","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1056\/NEJMoa1112304","volume":"366","author":"JP Patel","year":"2012","unstructured":"Patel, J. P., G\u00f6nen, M., Figueroa, M. E., et al. (2012). Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. New England Journal of Medicine, 366(12), 1079\u20131089. https:\/\/doi.org\/10.1056\/NEJMoa1112304","journal-title":"New England Journal of Medicine"},{"key":"10447_CR57","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1016\/j.biopha.2018.11.083","volume":"109","author":"J Xiang","year":"2019","unstructured":"Xiang, J., Wang, G., Xia, T., & Chen, Z. (2019). The depletion of PHF6 decreases the drug sensitivity of T-cell acute lymphoblastic leukemia to prednisolone. Biomedicine & Pharmacotherapy, 109, 2210\u20132217. https:\/\/doi.org\/10.1016\/j.biopha.2018.11.083","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"5","key":"10447_CR58","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1101\/gad.254151.114","volume":"29","author":"CE Meacham","year":"2015","unstructured":"Meacham, C. E., Lawton, L. N., Soto-Feliciano, Y. M., et al. (2015). A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth. Genes & Development, 29(5), 483\u2013488. https:\/\/doi.org\/10.1101\/gad.254151.114","journal-title":"Genes & Development"},{"issue":"15","key":"10447_CR59","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1182\/bloodadvances.2019000391","volume":"3","author":"YC Hsu","year":"2019","unstructured":"Hsu, Y. C., Chen, T. C., Lin, C. C., et al. (2019). Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentials. Blood Advances, 3(15), 2355\u20132367. https:\/\/doi.org\/10.1182\/bloodadvances.2019000391","journal-title":"Blood Advances"},{"issue":"16","key":"10447_CR60","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1182\/blood-2018-07-860726","volume":"133","author":"HM McRae","year":"2019","unstructured":"McRae, H. M., Garnham, A. L., Hu, Y., et al. (2019). PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia. Blood, 133(16), 1729\u20131741. https:\/\/doi.org\/10.1182\/blood-2018-07-860726","journal-title":"Blood"},{"issue":"23","key":"10447_CR61","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1182\/blood.2019000468","volume":"133","author":"S Miyagi","year":"2019","unstructured":"Miyagi, S., Sroczynska, P., Kato, Y., et al. (2019). The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells. Blood, 133(23), 2495\u20132506. https:\/\/doi.org\/10.1182\/blood.2019000468","journal-title":"Blood"}],"container-title":["Stem Cell Reviews and Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-022-10447-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12015-022-10447-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-022-10447-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T15:44:17Z","timestamp":1673019857000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12015-022-10447-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,26]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10447"],"URL":"https:\/\/doi.org\/10.1007\/s12015-022-10447-4","relation":{},"ISSN":["2629-3269","2629-3277"],"issn-type":[{"value":"2629-3269","type":"print"},{"value":"2629-3277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,26]]},"assertion":[{"value":"11 August 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional Review Board"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"The authors declare that they have no competing interests.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}}]}}