{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:19:58Z","timestamp":1790957998279,"version":"4.1.0"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Rev and Rep"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1007\/s12015-023-10505-5","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T13:02:54Z","timestamp":1673528574000},"page":"853-865","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Regenerative Medicine for Polycystic Ovary Syndrome: Stem Cell-Based Therapies and Brown Adipose Tissue Activation"],"prefix":"10.1007","volume":"19","author":[{"given":"Mario","family":"Karam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Najjar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan","family":"El Sabban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Hamade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7765-434X","authenticated-orcid":false,"given":"Fadia","family":"Najjar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,12]]},"reference":[{"issue":"4","key":"10505_CR1","doi-asserted-by":"publisher","first-page":"261","DOI":"10.4103\/jhrs.JHRS_95_18","volume":"13","author":"R Deswal","year":"2020","unstructured":"Deswal, R., Narwal, V., Dang, A., & Pundir, C. S. (2020). The Prevalence of Polycystic Ovary Syndrome: A Brief Systematic Review. Journal of Human Reproductive Sciences, 13(4), 261\u2013271. https:\/\/doi.org\/10.4103\/jhrs.JHRS_95_18","journal-title":"Journal of Human Reproductive Sciences"},{"issue":"1","key":"10505_CR2","doi-asserted-by":"publisher","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","volume":"2","author":"R Azziz","year":"2016","unstructured":"Azziz, R., et al. (2016). Polycystic ovary syndrome. Nature Reviews. Disease Primers, 2(1), 16057. https:\/\/doi.org\/10.1038\/nrdp.2016.57","journal-title":"Nature Reviews. Disease Primers"},{"issue":"1","key":"10505_CR3","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1056\/NEJMcp1514916","volume":"375","author":"CR McCartney","year":"2016","unstructured":"McCartney, C. R., & Marshall, J. C. (2016). Polycystic Ovary Syndrome. New England Journal of Medicine, 375(1), 54\u201364. https:\/\/doi.org\/10.1056\/NEJMcp1514916","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"10505_CR4","first-page":"279","volume":"80","author":"AT Ali","year":"2015","unstructured":"Ali, A. T. (2015). Polycystic ovary syndrome and metabolic syndrome. Ceska Gynekologie, 80(4), 279\u2013289.","journal-title":"Ceska Gynekologie"},{"issue":"3","key":"10505_CR5","doi-asserted-by":"publisher","first-page":"e387","DOI":"10.1016\/j.fertnstert.2019.07.1108","volume":"112","author":"FR Oliveira","year":"2019","unstructured":"Oliveira, F. R., et al. (2019). Brown adipose tissue in women with polycystic ovary syndrome: Relationship with body measures, plasma irisin levels and the use of metformin. Fertility and Sterility, 112(3), e387\u2013e388. https:\/\/doi.org\/10.1016\/j.fertnstert.2019.07.1108","journal-title":"Fertility and Sterility"},{"issue":"13","key":"10505_CR6","doi-asserted-by":"publisher","first-page":"4753","DOI":"10.3390\/ijms21134753","volume":"21","author":"MN Shafiee","year":"2020","unstructured":"Shafiee, M. N., Ortori, C. A., Barrett, D. A., Mongan, N. P., Abu, J., & Atiomo, W. (2020). Lipidomic Biomarkers in Polycystic Ovary Syndrome and Endometrial Cancer. International Journal of Molecular Sciences, 21(13), 4753. https:\/\/doi.org\/10.3390\/ijms21134753","journal-title":"International Journal of Molecular Sciences"},{"key":"10505_CR7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jnutbio.2017.04.012","volume":"47","author":"T Hu","year":"2017","unstructured":"Hu, T., et al. (2017). Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat. Journal of Nutritional Biochemistry, 47, 21\u201328. https:\/\/doi.org\/10.1016\/j.jnutbio.2017.04.012","journal-title":"Journal of Nutritional Biochemistry"},{"issue":"10","key":"10505_CR8","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.jcyt.2020.06.004","volume":"22","author":"K-Y Lu","year":"2020","unstructured":"Lu, K.-Y., Dass, K. T. P., Lin, S.-Z., Harn, H.-J., & Liu, S.-P. (2020). The application of stem cell therapy and brown adipose tissue transplantation in metabolic disorders. Cytotherapy, 22(10), 521\u2013528. https:\/\/doi.org\/10.1016\/j.jcyt.2020.06.004","journal-title":"Cytotherapy"},{"issue":"4","key":"10505_CR9","doi-asserted-by":"publisher","first-page":"S69","DOI":"10.1016\/j.jcyt.2014.01.254","volume":"16","author":"F Silva","year":"2014","unstructured":"Silva, F., Holt, D., Vargas, V., Bull, D., & Patel, A. N. (2014). Human metabolically active brown adipose tissue derived stem cells. Cytotherapy, 16(4), S69. https:\/\/doi.org\/10.1016\/j.jcyt.2014.01.254","journal-title":"Cytotherapy"},{"issue":"12","key":"10505_CR10","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.3390\/jcm10122688","volume":"10","author":"Y Zhang","year":"2021","unstructured":"Zhang, Y., Movva, V. C., Williams, M. S., & Lee, M. T. M. (2021). Polycystic Ovary Syndrome Susceptibility Loci Inform Disease Etiological Heterogeneity. Journal of Clinical Medicine, 10(12), 2688. https:\/\/doi.org\/10.3390\/jcm10122688","journal-title":"Journal of Clinical Medicine"},{"issue":"1","key":"10505_CR11","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.fertnstert.2016.05.011","volume":"106","author":"SS Merkin","year":"2016","unstructured":"Merkin, S. S., Phy, J. L., Sites, C. K., & Yang, D. (2016). Environmental determinants of polycystic ovary syndrome. Fertility and Sterility, 106(1), 16\u201324. https:\/\/doi.org\/10.1016\/j.fertnstert.2016.05.011","journal-title":"Fertility and Sterility"},{"key":"10505_CR12","doi-asserted-by":"publisher","unstructured":"Unluturk, U., Harmanci, A., Kocaefe, C., Yildiz, B. O. (2007). The Genetic Basis of the Polycystic Ovary Syndrome: A Literature Review Including Discussion of PPAR-\u03b3. PPAR Research, 2007. https:\/\/doi.org\/10.1155\/2007\/49109.","DOI":"10.1155\/2007\/49109"},{"key":"10505_CR13","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.bpobgyn.2016.03.005","volume":"37","author":"NE Baskind","year":"2016","unstructured":"Baskind, N. E., & Balen, A. H. (2016). Hypothalamic\u2013pituitary, ovarian and adrenal contributions to polycystic ovary syndrome. Best Practice & Research. Clinical Obstetrics & Gynaecology, 37, 80\u201397. https:\/\/doi.org\/10.1016\/j.bpobgyn.2016.03.005","journal-title":"Best Practice & Research. Clinical Obstetrics & Gynaecology"},{"issue":"5","key":"10505_CR14","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1093\/humupd\/dml020","volume":"12","author":"IE Messinis","year":"2006","unstructured":"Messinis, I. E. (2006). Ovarian feedback, mechanism of action and possible clinical implications. Human Reproduction Update, 12(5), 557\u2013571. https:\/\/doi.org\/10.1093\/humupd\/dml020","journal-title":"Human Reproduction Update"},{"issue":"1","key":"10505_CR15","doi-asserted-by":"publisher","first-page":"256","DOI":"10.4103\/jfmpc.jfmpc_281_18","volume":"8","author":"CK Nath","year":"2019","unstructured":"Nath, C. K., et al. (2019). Prolactin and thyroid stimulating hormone affecting the pattern of LH\/FSH secretion in patients with polycystic ovary syndrome: A hospital-based study from North East India. Journal of Family Medicine and Primary Care, 8(1), 256\u2013260. https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_281_18","journal-title":"Journal of Family Medicine and Primary Care"},{"issue":"3","key":"10505_CR16","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1210\/jcem.86.3.7318","volume":"86","author":"AJ Jakimiuk","year":"2001","unstructured":"Jakimiuk, A. J., Weitsman, S. R., Navab, A., & Magoffin, D. A. (2001). Luteinizing hormone receptor, steroidogenesis acute regulatory protein, and steroidogenic enzyme messenger ribonucleic acids are overexpressed in thecal and granulosa cells from polycystic ovaries. Journal of Clinical Endocrinology and Metabolism, 86(3), 1318\u20131323. https:\/\/doi.org\/10.1210\/jcem.86.3.7318","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"7","key":"10505_CR17","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1210\/jcem.83.7.4948","volume":"83","author":"R Azziz","year":"1998","unstructured":"Azziz, R., Black, V., Hines, G. A., Fox, L. M., & Boots, L. R. (1998). Adrenal Androgen Excess in the Polycystic Ovary Syndrome: Sensitivity and Responsivity of the Hypothalamic-Pituitary-Adrenal Axis1. Journal of Clinical Endocrinology and Metabolism, 83(7), 2317\u20132323. https:\/\/doi.org\/10.1210\/jcem.83.7.4948","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10505_CR18","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.mce.2012.07.011","volume":"373","author":"RJ Chang","year":"2013","unstructured":"Chang, R. J., & Cook-Andersen, H. (2013). Disordered follicle development. Molecular and Cellular Endocrinology, 373, 51\u201360. https:\/\/doi.org\/10.1016\/j.mce.2012.07.011","journal-title":"Molecular and Cellular Endocrinology"},{"issue":"1","key":"10505_CR19","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12958-020-00581-4","volume":"18","author":"R Tal","year":"2020","unstructured":"Tal, R., Seifer, C. M., Khanimov, M., Seifer, D. B., & Tal, O. (2020). High serum Antimullerian hormone levels are associated with lower live birth rates in women with polycystic ovarian syndrome undergoing assisted reproductive technology. Reproductive Biology and Endocrinology, 18(1), 20. https:\/\/doi.org\/10.1186\/s12958-020-00581-4","journal-title":"Reproductive Biology and Endocrinology"},{"issue":"4","key":"10505_CR20","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/nrendo.2010.217","volume":"7","author":"MO Goodarzi","year":"2011","unstructured":"Goodarzi, M. O., Dumesic, D. A., Chazenbalk, G., & Azziz, R. (2011). Polycystic ovary syndrome: Etiology, pathogenesis and diagnosis. Nature Reviews. Endocrinology, 7(4), 219\u2013231. https:\/\/doi.org\/10.1038\/nrendo.2010.217","journal-title":"Nature Reviews. Endocrinology"},{"issue":"2","key":"10505_CR21","first-page":"106","volume":"94","author":"T Williams","year":"2016","unstructured":"Williams, T., Mortada, R., & Porter, S. (2016). Diagnosis and Treatment of Polycystic Ovary Syndrome. American Family Physician, 94(2), 106\u2013113.","journal-title":"American Family Physician"},{"issue":"21","key":"10505_CR22","first-page":"4755","volume":"21","author":"G Franik","year":"2017","unstructured":"Franik, G., et al. (2017). The effect of abdominal obesity in patients with polycystic ovary syndrome on metabolic parameters. European Review for Medical and Pharmacological Sciences, 21(21), 4755\u20134761.","journal-title":"European Review for Medical and Pharmacological Sciences"},{"issue":"2","key":"10505_CR23","doi-asserted-by":"publisher","first-page":"593","DOI":"10.12669\/pjms.292.3180","volume":"29","author":"R Tabassum","year":"2013","unstructured":"Tabassum, R., Imtiaz, F., Sharafat, S., Shukar-ud-din, S., & Nusrat, U. (2013). Prevalence and clinical profile of insulin resistance in young women of poly cystic ovary syndrome: A study from Pakistan. Pakistan Journal of Medical Sciences, 29(2), 593\u2013596.","journal-title":"Pakistan Journal of Medical Sciences"},{"issue":"2","key":"10505_CR24","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s40618-020-01351-0","volume":"44","author":"P Moghetti","year":"2021","unstructured":"Moghetti, P., & Tosi, F. (2021). Insulin resistance and PCOS: Chicken or egg? Journal of Endocrinological Investigation, 44(2), 233\u2013244. https:\/\/doi.org\/10.1007\/s40618-020-01351-0","journal-title":"Journal of Endocrinological Investigation"},{"issue":"6","key":"10505_CR25","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1210\/edrv.18.6.0318","volume":"18","author":"A Dunaif","year":"1997","unstructured":"Dunaif, A. (1997). Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis. Endocrine Reviews, 18(6), 774\u2013800. https:\/\/doi.org\/10.1210\/edrv.18.6.0318","journal-title":"Endocrine Reviews"},{"issue":"6","key":"10505_CR26","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1210\/er.2011-1034","volume":"33","author":"E Diamanti-Kandarakis","year":"2012","unstructured":"Diamanti-Kandarakis, E., & Dunaif, A. (2012). Insulin resistance and the polycystic ovary syndrome revisited: An update on mechanisms and implications. Endocrine Reviews, 33(6), 981\u20131030. https:\/\/doi.org\/10.1210\/er.2011-1034","journal-title":"Endocrine Reviews"},{"issue":"6821","key":"10505_CR27","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/35055575","volume":"409","author":"ED Abel","year":"2001","unstructured":"Abel, E. D., et al. (2001). Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature, 409(6821), 729\u2013733. https:\/\/doi.org\/10.1038\/35055575","journal-title":"Nature"},{"issue":"3","key":"10505_CR28","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1093\/humrep\/der457","volume":"27","author":"S Bairagi","year":"2012","unstructured":"Bairagi, S., Gopal, J., Nathan, A. A., Babu, S. S., Kumar, N. P., & Dixit, M. (2012). Glucose-induced increase in circulating progenitor cells is blunted in polycystic amenorrhoeic subjects. Human Reproduction, 27(3), 844\u2013853. https:\/\/doi.org\/10.1093\/humrep\/der457","journal-title":"Human Reproduction"},{"key":"10505_CR29","doi-asserted-by":"publisher","first-page":"15313","DOI":"10.1038\/s41598-018-33575-9","volume":"8","author":"T-H Kim","year":"2018","unstructured":"Kim, T.-H., et al. (2018). 3D-cultured human placenta-derived mesenchymal stem cell spheroids enhance ovary function by inducing folliculogenesis. Science and Reports, 8, 15313. https:\/\/doi.org\/10.1038\/s41598-018-33575-9","journal-title":"Science and Reports"},{"issue":"3","key":"10505_CR30","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s00404-017-4429-2","volume":"296","author":"AP Delitala","year":"2017","unstructured":"Delitala, A. P., Capobianco, G., Delitala, G., Cherchi, P. L., & Dessole, S. (2017). Polycystic ovary syndrome, adipose tissue and metabolic syndrome. Archives of Gynecology and Obstetrics, 296(3), 405\u2013419. https:\/\/doi.org\/10.1007\/s00404-017-4429-2","journal-title":"Archives of Gynecology and Obstetrics"},{"key":"10505_CR31","doi-asserted-by":"publisher","unstructured":"Saito, M., Matsushita, M., Yoneshiro, T., Okamatsu-Ogura,Y. (2020). Brown Adipose Tissue, Diet-Induced Thermogenesis, and Thermogenic Food Ingredients: From Mice to Men. Frontiers in Endocrinology, 11. Accessed: Jun. 05, 2022. [Online]. Available: https:\/\/www.frontiersin.org\/article\/https:\/\/doi.org\/10.3389\/fendo.2020.00222.","DOI":"10.3389\/fendo.2020.00222"},{"issue":"1","key":"10505_CR32","doi-asserted-by":"publisher","first-page":"22","DOI":"10.4093\/dmj.2013.37.1.22","volume":"37","author":"M Saito","year":"2013","unstructured":"Saito, M. (2013). Brown Adipose Tissue as a Regulator of Energy Expenditure and Body Fat in Humans. Diabetes and Metabolism Journal, 37(1), 22\u201329. https:\/\/doi.org\/10.4093\/dmj.2013.37.1.22","journal-title":"Diabetes and Metabolism Journal"},{"issue":"6","key":"10505_CR33","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.2337\/db12-1430","volume":"62","author":"H Sacks","year":"2013","unstructured":"Sacks, H., & Symonds, M. E. (2013). Anatomical Locations of Human Brown Adipose Tissue. Diabetes, 62(6), 1783\u20131790. https:\/\/doi.org\/10.2337\/db12-1430","journal-title":"Diabetes"},{"key":"10505_CR34","doi-asserted-by":"publisher","unstructured":"Lu, W.-H. Chang, Y.-M., Huang, Y.-S. (2021). Alternative Polyadenylation and Differential Regulation of Ucp1: Implications for Brown Adipose Tissue Thermogenesis Across Species. Frontiers in Pediatrics, 8. Accessed: Jun. 05, 2022. [Online]. Available: https:\/\/www.frontiersin.org\/article\/https:\/\/doi.org\/10.3389\/fped.2020.612279.","DOI":"10.3389\/fped.2020.612279"},{"issue":"3","key":"10505_CR35","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/jcb.240430306","volume":"43","author":"AM Cassard","year":"1990","unstructured":"Cassard, A. M., et al. (1990). Human uncoupling protein gene: Structure, comparison with rat gene, and assignment to the long arm of chromosome 4. Journal of Cellular Biochemistry, 43(3), 255\u2013264. https:\/\/doi.org\/10.1002\/jcb.240430306","journal-title":"Journal of Cellular Biochemistry"},{"issue":"1","key":"10505_CR36","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1152\/physrev.00015.2003","volume":"84","author":"B Cannon","year":"2004","unstructured":"Cannon, B., & Nedergaard, J. (2004). Brown adipose tissue: Function and physiological significance. Physiological Reviews, 84(1), 277\u2013359. https:\/\/doi.org\/10.1152\/physrev.00015.2003","journal-title":"Physiological Reviews"},{"issue":"2","key":"10505_CR37","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1097\/MED.0b013e328337a81f","volume":"17","author":"AM Cypess","year":"2010","unstructured":"Cypess, A. M., & Kahn, C. R. (2010). Brown fat as a therapy for obesity and diabetes. Current Opinion in Endocrinology, Diabetes, and Obesity, 17(2), 143\u2013149. https:\/\/doi.org\/10.1097\/MED.0b013e328337a81f","journal-title":"Current Opinion in Endocrinology, Diabetes, and Obesity"},{"key":"10505_CR38","doi-asserted-by":"publisher","first-page":"108777","DOI":"10.1016\/j.ejrad.2019.108777","volume":"123","author":"L Li","year":"2020","unstructured":"Li, L., et al. (2020). Characterization of brown adipose tissue (BAT) in polycystic ovary syndrome (PCOS) patients by Z-Spectral Imaging (ZSI). European Journal of Radiology, 123, 108777. https:\/\/doi.org\/10.1016\/j.ejrad.2019.108777","journal-title":"European Journal of Radiology"},{"key":"10505_CR39","doi-asserted-by":"publisher","unstructured":"Fl\u00e1via R, O., et al. (2019). Brown adipose tissue activity is reduced in women with polycystic ovary syndrome. European Journal of Endocrinology, 181(5), 473\u2013480. https:\/\/doi.org\/10.1530\/EJE-19-0505.","DOI":"10.1530\/EJE-19-0505"},{"key":"10505_CR40","doi-asserted-by":"publisher","unstructured":"Patel, K., Patel, D. K. (2019). Chapter 26 - The Beneficial Role of Rutin, A Naturally Occurring Flavonoid in Health Promotion and Disease Prevention: A Systematic Review and Update. In: Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases (Second Edition), R. R. Watson and V. R. Preedy, Eds. Academic Press, pp. 457\u2013479. https:\/\/doi.org\/10.1016\/B978-0-12-813820-5.00026-X.","DOI":"10.1016\/B978-0-12-813820-5.00026-X"},{"issue":"1","key":"10505_CR41","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1096\/fj.201600459RR","volume":"31","author":"X Yuan","year":"2017","unstructured":"Yuan, X., et al. (2017). Rutin ameliorates obesity through brown fat activation. FASEB Journal: official publication of the Federation of American Societies for Experimental Biology, 31(1), 333\u2013345. https:\/\/doi.org\/10.1096\/fj.201600459RR","journal-title":"FASEB Journal: official publication of the Federation of American Societies for Experimental Biology"},{"key":"10505_CR42","doi-asserted-by":"publisher","unstructured":"Sharifi-Rad, J., et al. (2020). Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications. Frontiers in Pharmacology, 11, Accessed: Jun. 05, 2022. [Online]. Available: https:\/\/www.frontiersin.org\/article\/https:\/\/doi.org\/10.3389\/fphar.2020.01021.","DOI":"10.3389\/fphar.2020.01021"},{"issue":"2","key":"10505_CR43","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.bbrc.2015.09.018","volume":"466","author":"S Wang","year":"2015","unstructured":"Wang, S., et al. (2015). Curcumin promotes browning of white adipose tissue in a norepinephrine-dependent way. Biochemical and Biophysical Research Communications, 466(2), 247\u2013253. https:\/\/doi.org\/10.1016\/j.bbrc.2015.09.018","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10505_CR44","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.phytochem.2013.08.005","volume":"96","author":"GPP Kamatou","year":"2013","unstructured":"Kamatou, G. P. P., Vermaak, I., Viljoen, A. M., & Lawrence, B. M. (2013). Menthol: A simple monoterpene with remarkable biological properties. Phytochemistry, 96, 15\u201325. https:\/\/doi.org\/10.1016\/j.phytochem.2013.08.005","journal-title":"Phytochemistry"},{"issue":"2","key":"10505_CR45","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1093\/jmcb\/mjs001","volume":"4","author":"S Ma","year":"2012","unstructured":"Ma, S., et al. (2012). Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity. Journal of Molecular Cell Biology, 4(2), 88\u201396. https:\/\/doi.org\/10.1093\/jmcb\/mjs001","journal-title":"Journal of Molecular Cell Biology"},{"key":"10505_CR46","doi-asserted-by":"publisher","unstructured":"Wang, S., et al. (2015). Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) \u03b11. International Journal of Obesity, 39(6), 6. https:\/\/doi.org\/10.1038\/ijo.2015.23.","DOI":"10.1038\/ijo.2015.23"},{"issue":"6","key":"10505_CR47","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1093\/ajcn\/70.6.1040","volume":"70","author":"AG Dulloo","year":"1999","unstructured":"Dulloo, A. G., et al. (1999). Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. American Journal of Clinical Nutrition, 70(6), 1040\u20131045. https:\/\/doi.org\/10.1093\/ajcn\/70.6.1040","journal-title":"American Journal of Clinical Nutrition"},{"issue":"12","key":"10505_CR48","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1271\/bbb.90555","volume":"73","author":"F Kawabata","year":"2009","unstructured":"Kawabata, F., et al. (2009). Non-Pungent Capsaicin Analogs (Capsinoids) Increase Metabolic Rate and Enhance Thermogenesis via Gastrointestinal TRPV1 in Mice. Bioscience, Biotechnology, and Biochemistry, 73(12), 2690\u20132697. https:\/\/doi.org\/10.1271\/bbb.90555","journal-title":"Bioscience, Biotechnology, and Biochemistry"},{"key":"10505_CR49","doi-asserted-by":"publisher","first-page":"747944","DOI":"10.3389\/fendo.2021.747944","volume":"12","author":"L Yao","year":"2021","unstructured":"Yao, L., et al. (2021). Brown Adipose Transplantation Improves Polycystic Ovary Syndrome-Involved Metabolome Remodeling. Frontiers in Endocrinology, 12, 747944. https:\/\/doi.org\/10.3389\/fendo.2021.747944","journal-title":"Frontiers in Endocrinology"},{"issue":"2","key":"10505_CR50","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1530\/JOE-20-0068","volume":"248","author":"L Du","year":"2021","unstructured":"Du, L., et al. (2021). Rat BAT xenotransplantation recovers the fertility and metabolic health of PCOS mice. Journal of Endocrinology, 248(2), 249\u2013264. https:\/\/doi.org\/10.1530\/JOE-20-0068","journal-title":"Journal of Endocrinology"},{"issue":"10","key":"10505_CR51","doi-asserted-by":"publisher","first-page":"2708","DOI":"10.1073\/pnas.1523236113","volume":"113","author":"X Yuan","year":"2016","unstructured":"Yuan, X., et al. (2016). Brown adipose tissue transplantation ameliorates polycystic ovary syndrome. Proceedings of the National Academy of Sciences, 113(10), 2708\u20132713. https:\/\/doi.org\/10.1073\/pnas.1523236113","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10505_CR52","doi-asserted-by":"publisher","unstructured":"Zhang, Q., et al. (2022) Brown Adipose Tissue and Novel Management Strategies for Polycystic Ovary Syndrome Therapy. Frontiers in Endocrinology, 13. Accessed: Jun. 06, 2022. [Online]. Available: https:\/\/www.frontiersin.org\/article\/https:\/\/doi.org\/10.3389\/fendo.2022.847249.","DOI":"10.3389\/fendo.2022.847249"},{"key":"10505_CR53","doi-asserted-by":"publisher","unstructured":"Ye, R., et al. (2021) Brown Adipose Tissue Activation by Cold Treatment Ameliorates Polycystic Ovary Syndrome in Rat. Frontiers in Endocrinology, 12. https:\/\/doi.org\/10.3389\/fendo.2021.744628.","DOI":"10.3389\/fendo.2021.744628"},{"key":"10505_CR54","doi-asserted-by":"publisher","unstructured":"Ee, C. et al. (2018). Feasibility and acceptability of a proposed trial of acupuncture as an adjunct to lifestyle interventions for weight loss in Polycystic Ovary Syndrome: a qualitative study. BMC Complementary and Alternative Medicine, 18. https:\/\/doi.org\/10.1186\/s12906-018-2358-7.","DOI":"10.1186\/s12906-018-2358-7"},{"issue":"1","key":"10505_CR55","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s13020-022-00603-w","volume":"17","author":"H Gao","year":"2022","unstructured":"Gao, H., et al. (2022). Three-dimensional visualization of electroacupuncture-induced activation of brown adipose tissue via sympathetic innervation in PCOS rats. Chinese Medicine, 17(1), 48. https:\/\/doi.org\/10.1186\/s13020-022-00603-w","journal-title":"Chinese Medicine"},{"issue":"9","key":"10505_CR56","doi-asserted-by":"publisher","first-page":"3765","DOI":"10.1210\/jc.2013-1923","volume":"98","author":"TT Piltonen","year":"2013","unstructured":"Piltonen, T. T., et al. (2013). Mesenchymal Stem\/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential. Journal of Clinical Endocrinology and Metabolism, 98(9), 3765\u20133775. https:\/\/doi.org\/10.1210\/jc.2013-1923","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"1","key":"10505_CR57","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s13287-018-0950-x","volume":"9","author":"Z Min","year":"2018","unstructured":"Min, Z., et al. (2018). New insights into the genic and metabolic characteristics of induced pluripotent stem cells from polycystic ovary syndrome women. Stem Cell Research & Therapy, 9(1), 210. https:\/\/doi.org\/10.1186\/s13287-018-0950-x","journal-title":"Stem Cell Research & Therapy"},{"key":"10505_CR58","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/978-1-4614-2098-9_7","volume":"741","author":"A S\u00e1nchez","year":"2012","unstructured":"S\u00e1nchez, A., Schimmang, T., & Garc\u00eda-Sancho, J. (2012). Cell and tissue therapy in regenerative medicine. Advances in Experimental Medicine and Biology, 741, 89\u2013102. https:\/\/doi.org\/10.1007\/978-1-4614-2098-9_7","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"47","key":"10505_CR59","doi-asserted-by":"publisher","first-page":"14452","DOI":"10.1073\/pnas.1508520112","volume":"112","author":"AS Mao","year":"2015","unstructured":"Mao, A. S., & Mooney, D. J. (2015). Regenerative medicine: Current therapies and future directions. Proceedings of the National Academy of Sciences of the United States of America, 112(47), 14452\u201314459. https:\/\/doi.org\/10.1073\/pnas.1508520112","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10505_CR60","doi-asserted-by":"publisher","unstructured":"Park, H.-S., et al. (2022). Suppression pathway of androgen production through secreted proteins in msc based pcos treatment. Fertility and Sterility, 118(4), Supplement, e347. https:\/\/doi.org\/10.1016\/j.fertnstert.2022.09.148.","DOI":"10.1016\/j.fertnstert.2022.09.148"},{"key":"10505_CR61","doi-asserted-by":"publisher","unstructured":"Kalhori, Z., Azadbakht, M., Soleimani Mehranjani, M., Shariatzadeh, M. A. (2018) Improvement of the folliculogenesis by transplantation of bone marrow mesenchymal stromal cells in mice with induced polycystic ovary syndrome. Cytotherapy, 20(12), 1445\u20131458. https:\/\/doi.org\/10.1016\/j.jcyt.2018.09.005.","DOI":"10.1016\/j.jcyt.2018.09.005"},{"key":"10505_CR62","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1186\/s13287-021-02472-w","volume":"12","author":"RM Chugh","year":"2021","unstructured":"Chugh, R. M., et al. (2021). Mesenchymal stem cell therapy ameliorates metabolic dysfunction and restores fertility in a PCOS mouse model through interleukin-10. Stem Cell Research & Therapy, 12, 388. https:\/\/doi.org\/10.1186\/s13287-021-02472-w","journal-title":"Stem Cell Research & Therapy"},{"issue":"17","key":"10505_CR63","doi-asserted-by":"publisher","first-page":"9184","DOI":"10.3390\/ijms22179184","volume":"22","author":"RM Chugh","year":"2021","unstructured":"Chugh, R. M., Park, H., Esfandyari, S., Elsharoud, A., Ulin, M., & Al-Hendy, A. (2021). Mesenchymal Stem Cell-Conditioned Media Regulate Steroidogenesis and Inhibit Androgen Secretion in a PCOS Cell Model via BMP-2. International Journal of Molecular Sciences, 22(17), 9184. https:\/\/doi.org\/10.3390\/ijms22179184","journal-title":"International Journal of Molecular Sciences"},{"issue":"9","key":"10505_CR64","doi-asserted-by":"publisher","first-page":"4633","DOI":"10.3390\/ijms23094633","volume":"23","author":"H-S Park","year":"2022","unstructured":"Park, H.-S., et al. (2022). Non-Cytokine Protein Profile of the Mesenchymal Stem Cell Secretome That Regulates the Androgen Production Pathway. International Journal of Molecular Sciences, 23(9), 4633. https:\/\/doi.org\/10.3390\/ijms23094633","journal-title":"International Journal of Molecular Sciences"},{"key":"10505_CR65","doi-asserted-by":"publisher","first-page":"e9782373","DOI":"10.1155\/2019\/9782373","volume":"2019","author":"Q Xie","year":"2019","unstructured":"Xie, Q., et al. (2019). Mesenchymal Stem Cells Alleviate DHEA-Induced Polycystic Ovary Syndrome (PCOS) by Inhibiting Inflammation in Mice. Stem Cells International, 2019, e9782373. https:\/\/doi.org\/10.1155\/2019\/9782373","journal-title":"Stem Cells International"},{"key":"10505_CR66","doi-asserted-by":"publisher","first-page":"5750298","DOI":"10.1155\/2018\/5750298","volume":"2018","author":"S Julania","year":"2018","unstructured":"Julania, S., Walls, M. L., & Hart, R. (2018). The Place of In Vitro Maturation in PCO\/PCOS. International Journal of Endocrinology, 2018, 5750298. https:\/\/doi.org\/10.1155\/2018\/5750298","journal-title":"International Journal of Endocrinology"},{"key":"10505_CR67","doi-asserted-by":"publisher","unstructured":"Jafarzadeh, H., Nazarian, H., Ghaffari Novin, M., Shams Mofarahe, Z., Eini, F., Piryaei, A. (2018) Improvement of oocyte in vitro maturation from mice with polycystic ovary syndrome by human mesenchymal stromal cell\u2013conditioned media. Journal of Cellular Biochemistry, 119(12), 10365\u201310375. https:\/\/doi.org\/10.1002\/jcb.27380.","DOI":"10.1002\/jcb.27380"},{"issue":"1","key":"10505_CR68","doi-asserted-by":"publisher","first-page":"3804","DOI":"10.1080\/21691401.2019.1669619","volume":"47","author":"Y Zhao","year":"2019","unstructured":"Zhao, Y., Tao, M., Wei, M., Du, S., Wang, H., & Wang, X. (2019). Mesenchymal stem cells derived exosomal miR-323-3p promotes proliferation and inhibits apoptosis of cumulus cells in polycystic ovary syndrome (PCOS). Artificial Cells, Nanomedicine, and Biotechnology, 47(1), 3804\u20133813. https:\/\/doi.org\/10.1080\/21691401.2019.1669619","journal-title":"Artificial Cells, Nanomedicine, and Biotechnology"},{"key":"10505_CR69","doi-asserted-by":"publisher","first-page":"121739","DOI":"10.1016\/j.biomaterials.2022.121739","volume":"288","author":"M Cao","year":"2022","unstructured":"Cao, M., et al. (2022). Adipose mesenchymal stem cell\u2013derived exosomal microRNAs ameliorate polycystic ovary syndrome by protecting against metabolic disturbances. Biomaterials, 288, 121739. https:\/\/doi.org\/10.1016\/j.biomaterials.2022.121739","journal-title":"Biomaterials"},{"key":"10505_CR70","doi-asserted-by":"publisher","first-page":"103638","DOI":"10.1016\/j.jri.2022.103638","volume":"152","author":"Y Zhao","year":"2022","unstructured":"Zhao, Y., Pan, S., & Wu, X. (2022). Human umbilical cord mesenchymal stem cell-derived exosomes inhibit ovarian granulosa cells inflammatory response through inhibition of NF-\u03baB signaling in polycystic ovary syndrome. Journal of Reproductive Immunology, 152, 103638. https:\/\/doi.org\/10.1016\/j.jri.2022.103638","journal-title":"Journal of Reproductive Immunology"},{"key":"10505_CR71","doi-asserted-by":"publisher","unstructured":"Park, H., Ashour, D., Elsharoud, A., Chugh, R., Al-Hendy, A., El Andaloussi, A. (2019) Towards stem cell therapy of polycystic ovary syndrome (PCOS): therapeutic effect of human mesenchymal stem cells transplantation in pcos mouse model by regulating ovarian vascularization. Cytotherapy, 21(5, Supplement), S78. https:\/\/doi.org\/10.1016\/j.jcyt.2019.03.484.","DOI":"10.1016\/j.jcyt.2019.03.484"},{"key":"10505_CR72","doi-asserted-by":"publisher","unstructured":"Li, Y., Guo, J., Deng, S., Gao, Z., Liu, Y., Gu, Q. (2020) Fibrin Facilitates Mesenchymal Stem Cells to Ameliorate Rats with Polycystic Ovary Syndrome. Applied Sciences, 10(10), 10. https:\/\/doi.org\/10.3390\/app10103598.","DOI":"10.3390\/app10103598"},{"issue":"1","key":"10505_CR73","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41421-021-00291-0","volume":"7","author":"H Chen","year":"2021","unstructured":"Chen, H., et al. (2021). Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates. Cell Discovery, 7(1), 75. https:\/\/doi.org\/10.1038\/s41421-021-00291-0","journal-title":"Cell Discovery"},{"key":"10505_CR74","doi-asserted-by":"publisher","unstructured":"Wang, C.-H., et al. (2020). CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice. Science Translational Medicine, 12(558), eaaz8664. https:\/\/doi.org\/10.1126\/scitranslmed.aaz8664.","DOI":"10.1126\/scitranslmed.aaz8664"},{"issue":"3","key":"10505_CR75","doi-asserted-by":"publisher","first-page":"T75","DOI":"10.1530\/JME-13-0158","volume":"51","author":"S Carobbio","year":"2013","unstructured":"Carobbio, S., Rosen, B., & Vidal-Puig, A. (2013). Adipogenesis: New insights into brown adipose tissue differentiation. Journal of Molecular Endocrinology, 51(3), T75\u2013T85. https:\/\/doi.org\/10.1530\/JME-13-0158","journal-title":"Journal of Molecular Endocrinology"},{"key":"10505_CR76","doi-asserted-by":"publisher","unstructured":"Calvo, E., et al. (2021) Effects of stem cells from inducible brown adipose tissue on diet-induced obesity in mice. Scientific Report, 11(1), 1. https:\/\/doi.org\/10.1038\/s41598-021-93224-6.","DOI":"10.1038\/s41598-021-93224-6"},{"issue":"2","key":"10505_CR77","doi-asserted-by":"publisher","first-page":"235","DOI":"10.2337\/db17-0356","volume":"67","author":"H Zhao","year":"2018","unstructured":"Zhao, H., et al. (2018). Exosomes From Adipose-Derived Stem Cells Attenuate Adipose Inflammation and Obesity Through Polarizing M2 Macrophages and Beiging in White Adipose Tissue. Diabetes, 67(2), 235\u2013247. https:\/\/doi.org\/10.2337\/db17-0356","journal-title":"Diabetes"},{"issue":"4","key":"10505_CR78","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.trsl.2014.11.002","volume":"165","author":"S Roman","year":"2015","unstructured":"Roman, S., et al. (2015). Brown adipose tissue and novel therapeutic approaches to treat metabolic disorders. Translational Research, 165(4), 464\u2013479. https:\/\/doi.org\/10.1016\/j.trsl.2014.11.002","journal-title":"Translational Research"}],"container-title":["Stem Cell Reviews and Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-023-10505-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12015-023-10505-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-023-10505-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T14:35:44Z","timestamp":1684161344000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12015-023-10505-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,12]]},"references-count":78,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10505"],"URL":"https:\/\/doi.org\/10.1007\/s12015-023-10505-5","relation":{},"ISSN":["2629-3269","2629-3277"],"issn-type":[{"value":"2629-3269","type":"print"},{"value":"2629-3277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,12]]},"assertion":[{"value":"2 January 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publication"}},{"value":"The authors have no competing interests to declare that are relevant to the content of this article.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interests\/Competing Interest"}}]}}