{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T07:53:03Z","timestamp":1766908383759,"version":"3.37.3"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100018095","name":"Virginia-Maryland College of Veterinary Medicine","doi-asserted-by":"publisher","award":["118995"],"award-info":[{"award-number":["118995"]}],"id":[{"id":"10.13039\/100018095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011501","name":"Institute for Critical Technologies and Applied Science, Virginia Tech","doi-asserted-by":"publisher","award":["JFC2014_JIAHE958451025"],"award-info":[{"award-number":["JFC2014_JIAHE958451025"]}],"id":[{"id":"10.13039\/100011501","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Virginia's Commonwealth Health Research Board","award":["208-09-16JHE"],"award-info":[{"award-number":["208-09-16JHE"]}]},{"DOI":"10.13039\/100020477","name":"Edward Via College of Osteopathic Medicine","doi-asserted-by":"publisher","award":["PJ6SPVHJ"],"award-info":[{"award-number":["PJ6SPVHJ"]}],"id":[{"id":"10.13039\/100020477","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Rev and Rep"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1007\/s12015-023-10574-6","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T15:01:43Z","timestamp":1688223703000},"page":"2341-2360","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Keratose Hydrogel Drives Differentiation of Cardiac Vascular Smooth Muscle Progenitor Cells: Implications in Ischemic Treatment"],"prefix":"10.1007","volume":"19","author":[{"given":"Benjamin T.","family":"Ledford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Van Dyke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Barron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaonan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurora","family":"Cartaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youjing","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Ceylan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0640-5960","authenticated-orcid":false,"given":"Jia-Qiang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,7,1]]},"reference":[{"issue":"7","key":"10574_CR1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s11936-016-0464-8","volume":"18","author":"TR Foley","year":"2016","unstructured":"Foley, T. R., Waldo, S. W., & Armstrong, E. J. (2016). Medical therapy in peripheral artery disease and critical limb ischemia. Current Treatment Options in Cardiovascular Medicine, 18(7), 42\u201359. https:\/\/doi.org\/10.1007\/s11936-016-0464-8","journal-title":"Current Treatment Options in Cardiovascular Medicine"},{"issue":"5","key":"10574_CR2","doi-asserted-by":"publisher","first-page":"11294","DOI":"10.3390\/ijms160511294","volume":"16","author":"SM Krishna","year":"2015","unstructured":"Krishna, S. M., Moxon, J. V., & Golledge, J. (2015). A review of the pathophysiology and potential biomarkers for peripheral artery disease. International Journal of Molecular Sciences, 16(5), 11294\u201311322. https:\/\/doi.org\/10.3390\/ijms160511294","journal-title":"International Journal of Molecular Sciences"},{"issue":"7","key":"10574_CR3","doi-asserted-by":"publisher","first-page":"475","DOI":"10.3109\/07853890.2014.932618","volume":"46","author":"G Di Minno","year":"2014","unstructured":"Di Minno, G., Spadarella, G., Cafaro, G., Petitto, M., Lupoli, R., Di Minno, A., et al. (2014). Systematic reviews and meta-analyses for more profitable strategies in peripheral artery disease. Annals of Medicine, 46(7), 475\u2013489. https:\/\/doi.org\/10.3109\/07853890.2014.932618","journal-title":"Annals of Medicine"},{"key":"10574_CR4","doi-asserted-by":"publisher","first-page":"417","DOI":"10.2147\/VHRM.S50588","volume":"10","author":"A Swaminathan","year":"2014","unstructured":"Swaminathan, A., Vemulapalli, S., Patel, M. R., & Jones, W. S. (2014). Lower extremity amputation in peripheral artery disease: Improving patient outcomes. Vascular Health and Risk Management, 10, 417\u2013424. https:\/\/doi.org\/10.2147\/VHRM.S50588","journal-title":"Vascular Health and Risk Management"},{"issue":"7","key":"10574_CR5","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.jacc.2010.01.070","volume":"56","author":"SW Kim","year":"2010","unstructured":"Kim, S. W., Kim, H., Cho, H. J., Lee, J. U., Levit, R., & Yoon, Y. S. (2010). Human peripheral blood-derived CD31+ cells have robust angiogenic and vasculogenic properties and are effective for treating ischemic vascular disease. Journal of the American College of Cardiology, 56(7), 593\u2013607. https:\/\/doi.org\/10.1016\/j.jacc.2010.01.070","journal-title":"Journal of the American College of Cardiology"},{"issue":"1","key":"10574_CR6","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/978-1-4939-1453-1_13","volume":"1213","author":"L Martins","year":"2014","unstructured":"Martins, L., Martin, P. K., & Han, S. W. (2014). Angiogenic properties of mesenchymal stem cells in a mouse model of limb ischemia. Methods in Molecular Biology, 1213(1), 147\u2013169. https:\/\/doi.org\/10.1007\/978-1-4939-1453-1_13","journal-title":"Methods in Molecular Biology"},{"issue":"1","key":"10574_CR7","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/1471-2121-11-72","volume":"11","author":"H Suzuki","year":"2010","unstructured":"Suzuki, H., Shibata, R., Kito, T., Ishii, M., Li, P., Yoshikai, T., et al. (2010). Therapeutic angiogenesis by transplantation of induced pluripotent stem cell-derived Flk-1 positive cells. BMC Cell Biology, 11(1), 72\u201382. https:\/\/doi.org\/10.1186\/1471-2121-11-72","journal-title":"BMC Cell Biology"},{"issue":"6","key":"10574_CR8","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1161\/CIRCINTERVENTIONS.112.968321","volume":"5","author":"DW Losordo","year":"2012","unstructured":"Losordo, D. W., Kibbe, M. R., Mendelsohn, F., Marston, W., Driver, V. R., Sharafuddin, M., et al. (2012). A randomized, controlled pilot study of autologous CD34+ cell therapy for critical limb ischemia. Circulation Cardiovascular Interventions, 5(6), 821\u2013830. https:\/\/doi.org\/10.1161\/CIRCINTERVENTIONS.112.968321","journal-title":"Circulation Cardiovascular Interventions"},{"issue":"7","key":"10574_CR9","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1161\/CIRCRESAHA.108.175083","volume":"103","author":"P Foubert","year":"2008","unstructured":"Foubert, P., Matrone, G., Souttou, B., Lere-Dean, C., Barateau, V., Plouet, J., et al. (2008). Coadministration of endothelial and smooth muscle progenitor cells enhances the efficiency of proangiogenic cell-based therapy. Circulation Research, 103(7), 751\u2013760. https:\/\/doi.org\/10.1161\/CIRCRESAHA.108.175083","journal-title":"Circulation Research"},{"issue":"3","key":"10574_CR10","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1007\/s12015-014-9496-1","volume":"10","author":"J Whiteley","year":"2014","unstructured":"Whiteley, J., Bielecki, R., Li, M., Chua, S., Ward, M. R., Yamanaka, N., et al. (2014). An expanded population of CD34+ cells from frozen banked umbilical cord blood demonstrate tissue repair mechanisms of mesenchymal stromal cells and circulating angiogenic cells in an ischemic hind limb model. Stem Cell Reviews, 10(3), 338\u2013350. https:\/\/doi.org\/10.1007\/s12015-014-9496-1","journal-title":"Stem Cell Reviews"},{"issue":"9","key":"10574_CR11","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.1634\/stemcells.2008-0393","volume":"26","author":"K Iohara","year":"2008","unstructured":"Iohara, K., Zheng, L., Wake, H., Ito, M., Nabekura, J., Wakita, H., et al. (2008). A novel stem cell source for vasculogenesis in ischemia: Subfraction of side population cells from dental pulp. Stem Cells, 26(9), 2408\u20132418. https:\/\/doi.org\/10.1634\/stemcells.2008-0393","journal-title":"Stem Cells"},{"issue":"7697","key":"10574_CR12","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1038\/nature25771","volume":"555","author":"C Vicinanza","year":"2018","unstructured":"Vicinanza, C., Aquila, I., Cianflone, E., Scalise, M., Marino, F., Mancuso, T., et al. (2018). Kit(cre) knock-in mice fail to fate-map cardiac stem cells. Nature, 555(7697), E1\u2013E5. https:\/\/doi.org\/10.1038\/nature25771","journal-title":"Nature"},{"issue":"1","key":"10574_CR13","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1161\/CIRCRESAHA.118.313215","volume":"123","author":"B Zhou","year":"2018","unstructured":"Zhou, B., & Wu, S. M. (2018). Reassessment of c-kit in cardiac cells: A complex interplay between expression, fate, and function. Circulation Research, 123(1), 9\u201311. https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.313215","journal-title":"Circulation Research"},{"issue":"8","key":"10574_CR14","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1161\/CIRCULATIONAHA.118.035186","volume":"138","author":"BD Maliken","year":"2018","unstructured":"Maliken, B. D., & Molkentin, J. D. (2018). Undeniable evidence that the adult mammalian heart lacks an endogenous regenerative stem cell. Circulation, 138(8), 806\u2013808. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.118.035186","journal-title":"Circulation"},{"key":"10574_CR15","doi-asserted-by":"publisher","first-page":"3536854","DOI":"10.1155\/2018\/3536854","volume":"2018","author":"K Dergilev","year":"2018","unstructured":"Dergilev, K., Tsokolaeva, Z., Makarevich, P., Beloglazova, I., Zubkova, E., Boldyreva, M., et al. (2018). C-kit cardiac progenitor cell based cell sheet improves vascularization and attenuates cardiac remodeling following myocardial infarction in rats. Biomed Research International, 2018, 3536854. https:\/\/doi.org\/10.1155\/2018\/3536854","journal-title":"Biomed Research International"},{"issue":"12","key":"10574_CR16","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1089\/scd.2016.0351","volume":"26","author":"BT Ledford","year":"2017","unstructured":"Ledford, B. T., Simmons, J., Chen, M., Fan, H., Barron, C., Liu, Z., et al. (2017). Keratose hydrogels promote vascular smooth muscle differentiation from C-kit positive human cardiac stem cells. Stem Cells and Development, 26(12), 888\u2013900. https:\/\/doi.org\/10.1089\/scd.2016.0351","journal-title":"Stem Cells and Development"},{"issue":"3","key":"10574_CR17","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s00441-008-0654-0","volume":"333","author":"Y Narita","year":"2008","unstructured":"Narita, Y., Yamawaki, A., Kagami, H., Ueda, M., & Ueda, Y. (2008). Effects of transforming growth factor-beta 1 and ascorbic acid on differentiation of human bone-marrow-derived mesenchymal stem cells into smooth muscle cell lineage. Cell and Tissue Research, 333(3), 449\u2013459. https:\/\/doi.org\/10.1007\/s00441-008-0654-0","journal-title":"Cell and Tissue Research"},{"issue":"13\u201314","key":"10574_CR18","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1089\/ten.TEA.2010.0526","volume":"17","author":"CE Gacchina","year":"2011","unstructured":"Gacchina, C. E., Deb, P., Barth, J. L., & Ramamurthi, A. (2011). Elastogenic inductability of smooth muscle cells from a rat model of late stage abdominal aortic aneurysms. Tissue Engineering Part A, 17(13\u201314), 1699\u20131711. https:\/\/doi.org\/10.1089\/ten.TEA.2010.0526","journal-title":"Tissue Engineering Part A"},{"issue":"3","key":"10574_CR19","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1152\/japplphysiol.00870.2007","volume":"104","author":"N Shimizu","year":"2008","unstructured":"Shimizu, N., Yamamoto, K., Obi, S., Kumagaya, S., Masumura, T., Shimano, Y., et al. (2008). Cyclic strain induces mouse embryonic stem cell differentiation into vascular smooth muscle cells by activating PDGF receptor beta. Journal of Applied Physiology (1985), 104(3), 766\u2013772. https:\/\/doi.org\/10.1152\/japplphysiol.00870.2007","journal-title":"Journal of Applied Physiology (1985)"},{"issue":"Pt 6","key":"10574_CR20","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1242\/jcs.112.6.905","volume":"112","author":"KA Grako","year":"1999","unstructured":"Grako, K. A., Ochiya, T., Barritt, D., Nishiyama, A., & Stallcup, W. B. (1999). PDGF (alpha)-receptor is unresponsive to PDGF-AA in aortic smooth muscle cells from the NG2 knockout mouse. Journal of Cell Science, 112(Pt 6), 905\u2013915. https:\/\/doi.org\/10.1242\/jcs.112.6.905","journal-title":"Journal of Cell Science"},{"issue":"3","key":"10574_CR21","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/S0006-291X(02)00331-5","volume":"293","author":"K Kingsley","year":"2002","unstructured":"Kingsley, K., Huff, J. L., Rust, W. L., Carroll, K., Martinez, A. M., Fitchmun, M., et al. (2002). ERK1\/2 mediates PDGF-BB stimulated vascular smooth muscle cell proliferation and migration on laminin-5. Biochemical and Biophysical Research Communications, 293(3), 1000\u20131006. https:\/\/doi.org\/10.1016\/S0006-291X(02)00331-5","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"4","key":"10574_CR22","doi-asserted-by":"publisher","first-page":"C377","DOI":"10.1152\/ajpcell.00404.2012","volume":"305","author":"WS Park","year":"2013","unstructured":"Park, W. S., Heo, S. C., Jeon, E. S., da Hong, H., Son, Y. K., Ko, J. H., et al. (2013). Functional expression of smooth muscle-specific ion channels in TGF-beta(1)-treated human adipose-derived mesenchymal stem cells. American Journal of Physiology. Cell Physiology, 305(4), C377-391. https:\/\/doi.org\/10.1152\/ajpcell.00404.2012","journal-title":"American Journal of Physiology. Cell Physiology"},{"issue":"5","key":"10574_CR23","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1161\/ATVBAHA.115.305310","volume":"35","author":"B Balint","year":"2015","unstructured":"Balint, B., Yin, H., Chakrabarti, S., Chu, M. W., Sims, S. M., & Pickering, J. G. (2015). Collectivization of Vascular Smooth Muscle Cells via TGF-beta-Cadherin-11-Dependent Adhesive Switching. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(5), 1254\u20131264. https:\/\/doi.org\/10.1161\/ATVBAHA.115.305310","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"11","key":"10574_CR24","doi-asserted-by":"publisher","first-page":"e15523","DOI":"10.1371\/journal.pone.0015523","volume":"5","author":"T Oida","year":"2010","unstructured":"Oida, T., & Weiner, H. L. (2010). TGF-beta induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction. PLoS One, 5(11), e15523. https:\/\/doi.org\/10.1371\/journal.pone.0015523","journal-title":"PLoS One"},{"issue":"11","key":"10574_CR25","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/nrm2262","volume":"8","author":"P ten Dijke","year":"2007","unstructured":"ten Dijke, P., & Arthur, H. M. (2007). Extracellular control of TGFbeta signalling in vascular development and disease. Nature Reviews Molecular Cell Biology, 8(11), 857\u2013869. https:\/\/doi.org\/10.1038\/nrm2262","journal-title":"Nature Reviews Molecular Cell Biology"},{"issue":"3","key":"10574_CR26","doi-asserted-by":"publisher","first-page":"L413","DOI":"10.1152\/ajplung.90628.2008","volume":"299","author":"JS Mohamed","year":"2010","unstructured":"Mohamed, J. S., & Boriek, A. M. (2010). Stretch augments TGF-beta1 expression through RhoA\/ROCK1\/2, PTK, and PI3K in airway smooth muscle cells. American Journal of Physiology. Lung Cellular and Molecular Physiology, 299(3), L413-424. https:\/\/doi.org\/10.1152\/ajplung.90628.2008","journal-title":"American Journal of Physiology. Lung Cellular and Molecular Physiology"},{"issue":"6","key":"10574_CR27","doi-asserted-by":"publisher","first-page":"589","DOI":"10.2174\/092986732306160303151041","volume":"23","author":"RG Sahito","year":"2016","unstructured":"Sahito, R. G., Sureshkumar, P., Sotiriadou, I., Srinivasan, S. P., Sabour, D., Hescheler, J., et al. (2016). The potential application of biomaterials in cardiac stem cell therapy. Current Medicinal Chemistry, 23(6), 589\u2013602. https:\/\/doi.org\/10.2174\/092986732306160303151041","journal-title":"Current Medicinal Chemistry"},{"issue":"3\u20134","key":"10574_CR28","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1089\/ten.TEA.2013.0084","volume":"20","author":"LA Pace","year":"2014","unstructured":"Pace, L. A., Plate, J. F., Mannava, S., Barnwell, J. C., Koman, L. A., Li, Z., et al. (2014). A human hair keratin hydrogel scaffold enhances median nerve regeneration in nonhuman primates: An electrophysiological and histological study. Tissue Engineering Part A, 20(3\u20134), 507\u2013517. https:\/\/doi.org\/10.1089\/ten.TEA.2013.0084","journal-title":"Tissue Engineering Part A"},{"issue":"3","key":"10574_CR29","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.bioactmat.2020.04.007","volume":"5","author":"S Feroz","year":"2020","unstructured":"Feroz, S., Muhammad, N., Ranayake, J., & Dias, G. (2020). Keratin - based materials for biomedical applications. Bioactive Materials, 5(3), 496\u2013509. https:\/\/doi.org\/10.1016\/j.bioactmat.2020.04.007","journal-title":"Bioactive Materials"},{"issue":"8","key":"10574_CR30","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.semcdb.2021.06.017","volume":"128","author":"B Ledford","year":"2022","unstructured":"Ledford, B., Barron, C., Van Dyke, M., & He, J. Q. (2022). Keratose hydrogel for tissue regeneration and drug delivery. Seminars in Cell & Developmental Biology, 128(8), 145\u2013153. https:\/\/doi.org\/10.1016\/j.semcdb.2021.06.017","journal-title":"Seminars in Cell & Developmental Biology"},{"key":"10574_CR31","unstructured":"Worthington Biochem, C. (May 25, 2017). http:\/\/www.worthington-biochem.com\/cls\/default.html"},{"issue":"4","key":"10574_CR32","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.biomaterials.2009.09.076","volume":"31","author":"P Hill","year":"2010","unstructured":"Hill, P., Brantley, H., & Van Dyke, M. (2010). Some properties of keratin biomaterials: Kerateines. Biomaterials, 31(4), 585\u2013593. https:\/\/doi.org\/10.1016\/j.biomaterials.2009.09.076","journal-title":"Biomaterials"},{"issue":"32","key":"10574_CR33","doi-asserted-by":"publisher","first-page":"8205","DOI":"10.1016\/j.biomaterials.2011.07.054","volume":"32","author":"RC de Guzman","year":"2011","unstructured":"de Guzman, R. C., Merrill, M. R., Richter, J. R., Hamzi, R. I., Greengauz-Roberts, O. K., & Van Dyke, M. E. (2011). Mechanical and biological properties of keratose biomaterials. Biomaterials, 32(32), 8205\u20138217. https:\/\/doi.org\/10.1016\/j.biomaterials.2011.07.054","journal-title":"Biomaterials"},{"issue":"11","key":"10574_CR34","doi-asserted-by":"publisher","first-page":"e27719","DOI":"10.1371\/journal.pone.0027719","volume":"6","author":"JQ He","year":"2011","unstructured":"He, J. Q., Vu, D. M., Hunt, G., Chugh, A., Bhatnagar, A., & Bolli, R. (2011). Human cardiac stem cells isolated from atrial appendages stably express c-kit. PLoS One, 6(11), e27719. https:\/\/doi.org\/10.1371\/journal.pone.0027719","journal-title":"PLoS One"},{"issue":"4","key":"10574_CR35","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1002\/jbm.a.33147","volume":"98","author":"JM Saul","year":"2011","unstructured":"Saul, J. M., Ellenburg, M. D., de Guzman, R. C., & Van Dyke, M. (2011). Keratin hydrogels support the sustained release of bioactive ciprofloxacin. Journal of Biomedical Materials Research. Part A, 98(4), 544\u2013553. https:\/\/doi.org\/10.1002\/jbm.a.33147","journal-title":"Journal of Biomedical Materials Research. Part A"},{"issue":"6","key":"10574_CR36","doi-asserted-by":"publisher","first-page":"2753","DOI":"10.1038\/nprot.2006.430","volume":"1","author":"N Rajan","year":"2006","unstructured":"Rajan, N., Habermehl, J., Cote, M. F., Doillon, C. J., & Mantovani, D. (2006). Preparation of ready-to-use, storable and reconstituted type I collagen from rat tail tendon for tissue engineering applications. Nature Protocols, 1(6), 2753\u20132758. https:\/\/doi.org\/10.1038\/nprot.2006.430","journal-title":"Nature Protocols"},{"issue":"11","key":"10574_CR37","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1111\/j.1349-7006.2005.00103.x","volume":"96","author":"M Tojo","year":"2005","unstructured":"Tojo, M., Hamashima, Y., Hanyu, A., Kajimoto, T., Saitoh, M., Miyazono, K., et al. (2005). The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Science, 96(11), 791\u2013800. https:\/\/doi.org\/10.1111\/j.1349-7006.2005.00103.x","journal-title":"Cancer Science"},{"issue":"4","key":"10574_CR38","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.bbrc.2016.03.149","volume":"473","author":"A Kwiatkowski","year":"2016","unstructured":"Kwiatkowski, A., Piatkowski, M., Chen, M., Kan, L., Meng, Q., Fan, H., et al. (2016). Superior angiogenesis facilitates digit regrowth in MRL\/MpJ mice compared to C57BL\/6 mice. Biochemical and Biophysical Research Communications, 473(4), 907\u2013912. https:\/\/doi.org\/10.1016\/j.bbrc.2016.03.149","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"2","key":"10574_CR39","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.mvr.2016.12.006","volume":"110","author":"M Chen","year":"2017","unstructured":"Chen, M., Fan, H., Ledford, B. T., Farah, Z., Barron, C., Liu, Z., et al. (2017). Impacts of femoral artery and vein excision versus femoral artery excision on the hindlimb ischemic model in CD-1 mice. Microvascular Research, 110(2), 48\u201355. https:\/\/doi.org\/10.1016\/j.mvr.2016.12.006","journal-title":"Microvascular Research"},{"issue":"3","key":"10574_CR40","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s10549-017-4211-y","volume":"163","author":"Y Wu","year":"2017","unstructured":"Wu, Y., Tran, T., Dwabe, S., Sarkissyan, M., Kim, J., Nava, M., et al. (2017). A83\u201301 inhibits TGF-beta-induced upregulation of Wnt3 and epithelial to mesenchymal transition in HER2-overexpressing breast cancer cells. Breast Cancer Research and Treatment, 163(3), 449\u2013460. https:\/\/doi.org\/10.1007\/s10549-017-4211-y","journal-title":"Breast Cancer Research and Treatment"},{"issue":"3","key":"10574_CR41","doi-asserted-by":"publisher","first-page":"e17557","DOI":"10.1371\/journal.pone.0017557","volume":"6","author":"J Yu","year":"2011","unstructured":"Yu, J., Chau, K. F., Vodyanik, M. A., Jiang, J., & Jiang, Y. (2011). Efficient feeder-free episomal reprogramming with small molecules. PLoS One, 6(3), e17557. https:\/\/doi.org\/10.1371\/journal.pone.0017557","journal-title":"PLoS One"},{"issue":"5","key":"10574_CR42","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1161\/01.RES.0000238376.72592.a2","volume":"99","author":"CR Montague","year":"2006","unstructured":"Montague, C. R., Hunter, M. G., Gavrilin, M. A., Phillips, G. S., Goldschmidt-Clermont, P. J., & Marsh, C. B. (2006). Activation of estrogen receptor-alpha reduces aortic smooth muscle differentiation. Circulation Research, 99(5), 477\u2013484. https:\/\/doi.org\/10.1161\/01.RES.0000238376.72592.a2","journal-title":"Circulation Research"},{"issue":"1","key":"10574_CR43","doi-asserted-by":"publisher","first-page":"213","DOI":"10.5301\/jn.5000127","volume":"26","author":"N Wang","year":"2013","unstructured":"Wang, N., Wang, X., Sun, B., Zeng, M., Xing, C., Zhao, X., et al. (2013). Role of TGF-beta1 in production of fibronectin in vascular smooth muscle cells cultured under high-phosphate conditions. Journal of Nephrology, 26(1), 213\u2013218. https:\/\/doi.org\/10.5301\/jn.5000127","journal-title":"Journal of Nephrology"},{"issue":"1","key":"10574_CR44","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/jcmm.12168","volume":"18","author":"N Espagnolle","year":"2014","unstructured":"Espagnolle, N., Guilloton, F., Deschaseaux, F., Gadelorge, M., Sensebe, L., & Bourin, P. (2014). CD146 expression on mesenchymal stem cells is associated with their vascular smooth muscle commitment. Journal of Cellular and Molecular Medicine, 18(1), 104\u2013114. https:\/\/doi.org\/10.1111\/jcmm.12168","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"1","key":"10574_CR45","doi-asserted-by":"publisher","first-page":"e1384","DOI":"10.1371\/journal.pone.0001384","volume":"3","author":"FR Garcia-Gonzalo","year":"2008","unstructured":"Garcia-Gonzalo, F. R., & Izpisua Belmonte, J. C. (2008). Albumin-associated lipids regulate human embryonic stem cell self-renewal. PLoS One, 3(1), e1384. https:\/\/doi.org\/10.1371\/journal.pone.0001384","journal-title":"PLoS One"},{"issue":"2","key":"10574_CR46","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1002\/mrd.1080320204","volume":"32","author":"J Massague","year":"1992","unstructured":"Massague, J., Andres, J., Attisano, L., Cheifetz, S., Lopez-Casillas, F., Ohtsuki, M., et al. (1992). TGF-beta receptors. Molecular Reproduction and Development, 32(2), 99\u2013104. https:\/\/doi.org\/10.1002\/mrd.1080320204","journal-title":"Molecular Reproduction and Development"},{"issue":"1","key":"10574_CR47","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev-immunol-032713-120257","volume":"32","author":"MA Travis","year":"2014","unstructured":"Travis, M. A., & Sheppard, D. (2014). TGF-beta activation and function in immunity. Annual Review of Immunology, 32(1), 51\u201382. https:\/\/doi.org\/10.1146\/annurev-immunol-032713-120257","journal-title":"Annual Review of Immunology"},{"issue":"10","key":"10574_CR48","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1002\/jbm.a.36460","volume":"106","author":"TA Horbett","year":"2018","unstructured":"Horbett, T. A. (2018). Fibrinogen adsorption to biomaterials. Journal of Biomedical Materials Research. Part A, 106(10), 2777\u20132788. https:\/\/doi.org\/10.1002\/jbm.a.36460","journal-title":"Journal of Biomedical Materials Research. Part A"},{"issue":"11","key":"10574_CR49","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1038\/nprot.2008.172","volume":"3","author":"Y Li","year":"2008","unstructured":"Li, Y., Song, Y., Zhao, L., Gaidosh, G., Laties, A. M., & Wen, R. (2008). Direct labeling and visualization of blood vessels with lipophilic carbocyanine dye DiI. Nature Protocols, 3(11), 1703\u20131708. https:\/\/doi.org\/10.1038\/nprot.2008.172","journal-title":"Nature Protocols"},{"issue":"7","key":"10574_CR50","doi-asserted-by":"publisher","first-page":"e40","DOI":"10.1161\/CIRCRESAHA.116.304668","volume":"116","author":"PJ Kim","year":"2015","unstructured":"Kim, P. J., Mahmoudi, M., Ge, X., Matsuura, Y., Toma, I., Metzler, S., et al. (2015). Direct evaluation of myocardial viability and stem cell engraftment demonstrates salvage of the injured myocardium. Circulation Research, 116(7), e40-50. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.304668","journal-title":"Circulation Research"},{"issue":"5","key":"10574_CR51","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1517\/17460441.2.5.739","volume":"2","author":"JQ He","year":"2007","unstructured":"He, J. Q., January, C. T., Thomson, J. A., & Kamp, T. J. (2007). Human embryonic stem cell-derived cardiomyocytes: Drug discovery and safety pharmacology. Expert Opinion on Drug Discovery, 2(5), 739\u2013753. https:\/\/doi.org\/10.1517\/17460441.2.5.739","journal-title":"Expert Opinion on Drug Discovery"},{"issue":"5\u20136","key":"10574_CR52","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1089\/ten.TEA.2010.0430","volume":"17","author":"SH Oh","year":"2011","unstructured":"Oh, S. H., Kim, I. G., Lee, J. Y., Lee, J. Y., & Lee, J. H. (2011). Bioactive porous beads as an injectable urethral bulking agent: Their in vitro evaluation on smooth muscle cell differentiation. Tissue Engineering Part A, 17(5\u20136), 655\u2013664. https:\/\/doi.org\/10.1089\/ten.TEA.2010.0430","journal-title":"Tissue Engineering Part A"},{"key":"10574_CR53","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.actbio.2015.11.051","volume":"31","author":"M Floren","year":"2016","unstructured":"Floren, M., Bonani, W., Dharmarajan, A., Motta, A., Migliaresi, C., & Tan, W. (2016). Human mesenchymal stem cells cultured on silk hydrogels with variable stiffness and growth factor differentiate into mature smooth muscle cell phenotype. Acta Biomaterialia, 31, 156\u2013166. https:\/\/doi.org\/10.1016\/j.actbio.2015.11.051","journal-title":"Acta Biomaterialia"},{"issue":"3","key":"10574_CR54","doi-asserted-by":"publisher","first-page":"203","DOI":"10.4252\/wjsc.v12.i3.203","volume":"12","author":"P Mallis","year":"2020","unstructured":"Mallis, P., Papapanagiotou, A., Katsimpoulas, M., Kostakis, A., Siasos, G., Kassi, E., et al. (2020). Efficient differentiation of vascular smooth muscle cells from Wharton\u2019s Jelly mesenchymal stromal cells using human platelet lysate: A potential cell source for small blood vessel engineering. World Journal of Stem Cells, 12(3), 203\u2013221. https:\/\/doi.org\/10.4252\/wjsc.v12.i3.203","journal-title":"World Journal of Stem Cells"},{"issue":"8","key":"10574_CR55","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/ncb3205","volume":"17","author":"C Patsch","year":"2015","unstructured":"Patsch, C., Challet-Meylan, L., Thoma, E. C., Urich, E., Heckel, T., O\u2019Sullivan, J. F., et al. (2015). Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nature Cell Biology, 17(8), 994\u20131003. https:\/\/doi.org\/10.1038\/ncb3205","journal-title":"Nature Cell Biology"},{"issue":"6","key":"10574_CR56","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.biomaterials.2015.04.055","volume":"60","author":"P Campagnolo","year":"2015","unstructured":"Campagnolo, P., Tsai, T. N., Hong, X., Kirton, J. P., So, P. W., Margariti, A., et al. (2015). c-Kit+ progenitors generate vascular cells for tissue-engineered grafts through modulation of the Wnt\/Klf4 pathway. Biomaterials, 60(6), 53\u201361. https:\/\/doi.org\/10.1016\/j.biomaterials.2015.04.055","journal-title":"Biomaterials"},{"issue":"5","key":"10574_CR57","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.ejcb.2005.11.007","volume":"85","author":"A Rama","year":"2006","unstructured":"Rama, A., Matsushita, T., Charolidi, N., Rothery, S., Dupont, E., & Severs, N. J. (2006). Up-regulation of connexin43 correlates with increased synthetic activity and enhanced contractile differentiation in TGF-beta-treated human aortic smooth muscle cells. European Journal of Cell Biology, 85(5), 375\u2013386. https:\/\/doi.org\/10.1016\/j.ejcb.2005.11.007","journal-title":"European Journal of Cell Biology"},{"issue":"2","key":"10574_CR58","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s12015-010-9144-3","volume":"6","author":"E Vo","year":"2010","unstructured":"Vo, E., Hanjaya-Putra, D., Zha, Y., Kusuma, S., & Gerecht, S. (2010). Smooth-muscle-like cells derived from human embryonic stem cells support and augment cord-like structures in vitro. Stem Cell Reviews, 6(2), 237\u2013247. https:\/\/doi.org\/10.1007\/s12015-010-9144-3","journal-title":"Stem Cell Reviews"},{"issue":"7","key":"10574_CR59","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.tcm.2006.04.005","volume":"16","author":"K Yokote","year":"2006","unstructured":"Yokote, K., Kobayashi, K., & Saito, Y. (2006). The role of Smad3-dependent TGF-beta signal in vascular response to injury. Trends in Cardiovascular Medicine, 16(7), 240\u2013245. https:\/\/doi.org\/10.1016\/j.tcm.2006.04.005","journal-title":"Trends in Cardiovascular Medicine"},{"issue":"2","key":"10574_CR60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.semcdb.2019.12.001","volume":"100","author":"JQ He","year":"2020","unstructured":"He, J. Q., & Barron, C. (2020). Signaling pathways in modulation of tissue and organ regeneration in vertebrates. Seminars in Cell & Developmental Biology, 100(2), 1\u20132. https:\/\/doi.org\/10.1016\/j.semcdb.2019.12.001","journal-title":"Seminars in Cell & Developmental Biology"},{"issue":"11","key":"10574_CR61","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1161\/ATVBAHA.111.226670","volume":"31","author":"BN Davis-Dusenbery","year":"2011","unstructured":"Davis-Dusenbery, B. N., Wu, C., & Hata, A. (2011). Micromanaging vascular smooth muscle cell differentiation and phenotypic modulation. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(11), 2370\u20132377. https:\/\/doi.org\/10.1161\/ATVBAHA.111.226670","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"2","key":"10574_CR62","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/0012-1606(91)90081-d","volume":"143","author":"VM Paralkar","year":"1991","unstructured":"Paralkar, V. M., Vukicevic, S., & Reddi, A. H. (1991). Transforming growth factor beta type 1 binds to collagen IV of basement membrane matrix: Implications for development. Developmental Biology, 143(2), 303\u2013308. https:\/\/doi.org\/10.1016\/0012-1606(91)90081-d","journal-title":"Developmental Biology"},{"issue":"5","key":"10574_CR63","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.matbio.2015.05.006","volume":"47","author":"B Hinz","year":"2015","unstructured":"Hinz, B. (2015). The extracellular matrix and transforming growth factor-beta1: Tale of a strained relationship. Matrix Biology, 47(5), 54\u201365. https:\/\/doi.org\/10.1016\/j.matbio.2015.05.006","journal-title":"Matrix Biology"},{"issue":"3","key":"10574_CR64","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/mabi.201200317","volume":"13","author":"AP Mathew","year":"2013","unstructured":"Mathew, A. P., Oksman, K., Pierron, D., & Harmand, M. F. (2013). Biocompatible fibrous networks of cellulose nanofibres and collagen crosslinked using genipin: Potential as artificial ligament\/tendons. Macromolecular Bioscience, 13(3), 289\u2013298. https:\/\/doi.org\/10.1002\/mabi.201200317","journal-title":"Macromolecular Bioscience"},{"issue":"3","key":"10574_CR65","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/term.1522","volume":"8","author":"A Satyam","year":"2014","unstructured":"Satyam, A., Subramanian, G. S., Raghunath, M., Pandit, A., & Zeugolis, D. I. (2014). In vitro evaluation of Ficoll-enriched and genipin-stabilised collagen scaffolds. Journal of Tissue Engineering and Regenerative Medicine, 8(3), 233\u2013241. https:\/\/doi.org\/10.1002\/term.1522","journal-title":"Journal of Tissue Engineering and Regenerative Medicine"},{"issue":"4","key":"10574_CR66","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.yjmcc.2008.03.009","volume":"45","author":"TE Robey","year":"2008","unstructured":"Robey, T. E., Saiget, M. K., Reinecke, H., & Murry, C. E. (2008). Systems approaches to preventing transplanted cell death in cardiac repair. Journal of Molecular and Cellular Cardiology, 45(4), 567\u2013581. https:\/\/doi.org\/10.1016\/j.yjmcc.2008.03.009","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"7790","key":"10574_CR67","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/s41586-019-1802-2","volume":"577","author":"RJ Vagnozzi","year":"2020","unstructured":"Vagnozzi, R. J., Maillet, M., Sargent, M. A., Khalil, H., Johansen, A. K. Z., Schwanekamp, J. A., et al. (2020). An acute immune response underlies the benefit of cardiac stem cell therapy. Nature, 577(7790), 405\u2013409. https:\/\/doi.org\/10.1038\/s41586-019-1802-2","journal-title":"Nature"},{"issue":"33","key":"10574_CR68","doi-asserted-by":"publisher","first-page":"8149","DOI":"10.1016\/j.biomaterials.2013.07.001","volume":"34","author":"CH Yoo","year":"2013","unstructured":"Yoo, C. H., Na, H. J., Lee, D. S., Heo, S. C., An, Y., Cha, J., et al. (2013). Endothelial progenitor cells from human dental pulp-derived iPS cells as a therapeutic target for ischemic vascular diseases. Biomaterials, 34(33), 8149\u20138160. https:\/\/doi.org\/10.1016\/j.biomaterials.2013.07.001","journal-title":"Biomaterials"},{"issue":"7","key":"10574_CR69","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.3727\/096368913X672064","volume":"24","author":"P Foubert","year":"2015","unstructured":"Foubert, P., Squiban, C., Holler, V., Buard, V., Dean, C., Levy, B. I., et al. (2015). Strategies to enhance the efficiency of endothelial progenitor cell therapy by Ephrin B2 pretreatment and coadministration with smooth muscle progenitor cells on vascular function during the wound-healing process in irradiated or nonirradiated condition. Cell Transplantation, 24(7), 1343\u20131361. https:\/\/doi.org\/10.3727\/096368913X672064","journal-title":"Cell Transplantation"},{"issue":"1","key":"10574_CR70","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s12967-017-1156-1","volume":"15","author":"IS Zakharova","year":"2017","unstructured":"Zakharova, I. S., Zhiven, M. K., Saaya, S. B., Shevchenko, A. I., Smirnova, A. M., Strunov, A., et al. (2017). Endothelial and smooth muscle cells derived from human cardiac explants demonstrate angiogenic potential and suitable for design of cell-containing vascular grafts. Journal of Translational Medicine, 15(1), 54\u201372. https:\/\/doi.org\/10.1186\/s12967-017-1156-1","journal-title":"Journal of Translational Medicine"},{"issue":"6","key":"10574_CR71","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1161\/CIRCULATIONAHA.112.116103","volume":"127","author":"JC Ryu","year":"2013","unstructured":"Ryu, J. C., Davidson, B. P., Xie, A., Qi, Y., Zha, D., Belcik, J. T., et al. (2013). Molecular imaging of the paracrine proangiogenic effects of progenitor cell therapy in limb ischemia. Circulation, 127(6), 710\u2013719. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.112.116103","journal-title":"Circulation"}],"container-title":["Stem Cell Reviews and Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-023-10574-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12015-023-10574-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-023-10574-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T09:18:23Z","timestamp":1697447903000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12015-023-10574-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,1]]},"references-count":71,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10574"],"URL":"https:\/\/doi.org\/10.1007\/s12015-023-10574-6","relation":{},"ISSN":["2629-3269","2629-3277"],"issn-type":[{"type":"print","value":"2629-3269"},{"type":"electronic","value":"2629-3277"}],"subject":[],"published":{"date-parts":[[2023,7,1]]},"assertion":[{"value":"8 June 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in this study that involved human waste tissues and animal study were approved by the Institutional Review Board (IRB), Institutional Biosafety Committee (IBC), and Institutional Animal Care and Use Committee (IACUC) at Virginia Tech.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All study participants provided written informed consent prior to enrolment.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"This manuscript has been approved by all authors and is solely the work of the authors named.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors have no competing interests to declare that are relevant to the content of this article.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}},{"value":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third-party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit .","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Open Access"}}]}}