{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:56:23Z","timestamp":1786982183933,"version":"build-2736575974"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Pioneer\u201d and \u201cLeading Goose\u201d R&D Program of Zhejiang province","award":["2024C03144"],"award-info":[{"award-number":["2024C03144"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82204516"],"award-info":[{"award-number":["82204516"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Rev and Rep"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s12015-025-10929-1","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T21:05:34Z","timestamp":1751058334000},"page":"2253-2271","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Direct Lineage Reprogramming of Fibroblasts into Functional Keratinocyte-Like Cells via BMI1 and FGFR2b for Diabetic Wound Repair"],"prefix":"10.1007","volume":"21","author":[{"given":"Hongrui","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizheng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peihua","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhuai","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaojun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,28]]},"reference":[{"key":"10929_CR1","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1021\/acscentsci.8b00850","volume":"5","author":"H Wu","year":"2019","unstructured":"Wu, H., Li, F., Shao, W., Gao, J., & Ling, D. (2019). Promoting angiogenesis in oxidative diabetic wound microenvironment using a nanozyme-reinforced self-protecting hydrogel. ACS Central Science,5, 477\u2013485.","journal-title":"ACS Central Science"},{"key":"10929_CR2","doi-asserted-by":"publisher","first-page":"4678","DOI":"10.1038\/s41467-020-18276-0","volume":"11","author":"AP Sawaya","year":"2020","unstructured":"Sawaya, A. P., et al. (2020). Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing. Nature Communications,11, 4678.","journal-title":"Nature Communications"},{"key":"10929_CR3","first-page":"203","volume":"402","author":"GBD 2021 Diabetes Collaborators","year":"2021","unstructured":"GBD 2021 Diabetes Collaborators. (2021). Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: A systematic analysis for the global burden of disease study 2021. The Lancet London England,402, 203\u2013234.","journal-title":"The Lancet London England"},{"key":"10929_CR4","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1056\/NEJMra1615439","volume":"376","author":"DG Armstrong","year":"2017","unstructured":"Armstrong, D. G., Boulton, A. J. M., & Bus, S. A. (2017). Diabetic foot ulcers and their recurrence. New England Journal of Medicine,376, 2367\u20132375.","journal-title":"New England Journal of Medicine"},{"key":"10929_CR5","unstructured":"Etiology, Epidemiology, and Disparities in the Burden of Diabetic Foot Ulcers - PubMed. https:\/\/pubmed.ncbi.nlm.nih.gov\/36548709\/.\u00a0Accessed 26 Mar 2025."},{"key":"10929_CR6","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.2174\/1381612013397573","volume":"7","author":"M Gharaee-Kermani","year":"2001","unstructured":"Gharaee-Kermani, M., & Phan, S. H. (2001). Role of cytokines and cytokine therapy in wound healing and fibrotic diseases. Current Pharmaceutical Design,7, 1083\u20131103.","journal-title":"Current Pharmaceutical Design"},{"key":"10929_CR7","doi-asserted-by":"publisher","first-page":"305","DOI":"10.2165\/00128071-200102050-00005","volume":"2","author":"YM Bello","year":"2001","unstructured":"Bello, Y. M., Falabella, A. F., & Eaglstein, W. H. (2001). Tissue-engineered skin. Current status in wound healing. American Journal of Clinical Dermatology,2, 305\u2013313.","journal-title":"American Journal of Clinical Dermatology"},{"key":"10929_CR8","doi-asserted-by":"publisher","first-page":"998","DOI":"10.2337\/dc09-1754","volume":"33","author":"M L\u00f6ndahl","year":"2010","unstructured":"L\u00f6ndahl, M., Katzman, P., Nilsson, A., & Hammarlund, C. (2010). Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes. Diabetes Care,33, 998\u20131003.","journal-title":"Diabetes Care"},{"key":"10929_CR9","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1111\/j.1524-475X.2012.00846.x","volume":"20","author":"F Jim\u00e9nez","year":"2012","unstructured":"Jim\u00e9nez, F., et al. (2012). A pilot clinical study of hair grafting in chronic leg ulcers. Wound Repair and Regeneration: Official Publication of the Wound Healing Society [and] the European Tissue Repair Society,20, 806\u2013814.","journal-title":"Wound Repair and Regeneration: Official Publication of the Wound Healing Society [and] the European Tissue Repair Society"},{"key":"10929_CR10","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3892\/ijmm.2021.5006","volume":"48","author":"A Magenta","year":"2021","unstructured":"Magenta, A., Florio, M. C., Ruggeri, M., & Furgiuele, S. (2021). Autologous cell therapy in diabetes-associated critical limb ischemia: From basic studies to clinical outcomes (Review). International Journal of Molecular Medicine,48, 173.","journal-title":"International Journal of Molecular Medicine"},{"key":"10929_CR11","doi-asserted-by":"publisher","first-page":"7428316","DOI":"10.1155\/2017\/7428316","volume":"2017","author":"HC Caldas","year":"2017","unstructured":"Caldas, H. C., et al. (2017). induced pluripotent stem cells reduce progression of experimental chronic kidney disease but develop wilms\u2019 tumors. Stem Cells Int.,2017, 7428316.","journal-title":"Stem Cells Int."},{"key":"10929_CR12","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nbt950","volume":"22","author":"RJ Morris","year":"2004","unstructured":"Morris, R. J., et al. (2004). Capturing and profiling adult hair follicle stem cells. Nature Biotechnology,22, 411\u2013417.","journal-title":"Nature Biotechnology"},{"key":"10929_CR13","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1038\/ng.431","volume":"41","author":"H Nguyen","year":"2009","unstructured":"Nguyen, H., et al. (2009). Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nature Genetics,41, 1068\u20131075.","journal-title":"Nature Genetics"},{"key":"10929_CR14","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1089\/wound.2014.0522","volume":"3","author":"CJ Lewis","year":"2014","unstructured":"Lewis, C. J., Mardaryev, A. N., Sharov, A. A., Fessing, M. Y., & Botchkarev, V. A. (2014). The epigenetic regulation of wound healing. Advances in Wound Care,3, 468\u2013475.","journal-title":"Advances in Wound Care"},{"key":"10929_CR15","doi-asserted-by":"publisher","first-page":"17861","DOI":"10.3390\/ijms140917861","volume":"14","author":"Q Shen","year":"2013","unstructured":"Shen, Q., Jin, H., & Wang, X. (2013). Epidermal stem cells and their epigenetic regulation. International Journal of Molecular Sciences,14, 17861\u201317880.","journal-title":"International Journal of Molecular Sciences"},{"key":"10929_CR16","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","volume":"126","author":"K Takahashi","year":"2006","unstructured":"Takahashi, K., & Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell,126, 663\u2013676.","journal-title":"Cell"},{"key":"10929_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/cell.2020.0046","volume":"23","author":"SK Sah","year":"2021","unstructured":"Sah, S. K., Kanaujiya, J. K., Chen, I.-P., & Reichenberger, E. J. (2021). Generation of keratinocytes from human induced pluripotent stem cells under defined culture conditions. Cellular Reprogramming,23, 1\u201313.","journal-title":"Cellular Reprogramming"},{"key":"10929_CR18","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/s41586-018-0477-4","volume":"561","author":"M Kurita","year":"2018","unstructured":"Kurita, M., et al. (2018). In vivo reprogramming of wound-resident cells generates skin epithelial tissue. Nature,561, 243\u2013247.","journal-title":"Nature"},{"key":"10929_CR19","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s12929-020-00642-1","volume":"27","author":"J Zheng","year":"2020","unstructured":"Zheng, J., et al. (2020). Long-term expansion of directly reprogrammed keratinocyte-like cells and in vitro reconstitution of human skin. Journal of Biomedical Science,27, 56.","journal-title":"Journal of Biomedical Science"},{"key":"10929_CR20","unstructured":"Differentiation of mouse induced pluripotent stem cells into a multipotent keratinocyte lineage - PubMed. https:\/\/pubmed.ncbi.nlm.nih.gov\/21150926\/. Accessed 26 Mar 2025."},{"key":"10929_CR21","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s13287-016-0357-5","volume":"7","author":"D Iacovides","year":"2016","unstructured":"Iacovides, D., Rizki, G., Lapathitis, G., & Strati, K. (2016). Direct conversion of mouse embryonic fibroblasts into functional keratinocytes through transient expression of pluripotency-related genes. Stem Cell Research & Therapy,7, 98.","journal-title":"Stem Cell Research & Therapy"},{"key":"10929_CR22","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/jid.2013.327","volume":"134","author":"Y Chen","year":"2014","unstructured":"Chen, Y., Mistry, D. S., & Sen, G. L. (2014). Highly rapid and efficient conversion of human fibroblasts to keratinocyte-like cells. The Journal of Investigative Dermatology,134, 335\u2013344.","journal-title":"The Journal of Investigative Dermatology"},{"key":"10929_CR23","unstructured":"Epidermal homeostasis: a balancing act of stem cells in the skin - PubMed. https:\/\/pubmed.ncbi.nlm.nih.gov\/19209183\/. Accessed 26 Mar 2025."},{"key":"10929_CR24","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.cytogfr.2005.01.001","volume":"16","author":"VP Eswarakumar","year":"2005","unstructured":"Eswarakumar, V. P., Lax, I., & Schlessinger, J. (2005). Cellular signaling by fibroblast growth factor receptors. Cytokine & Growth Factor Reviews,16, 139\u2013149.","journal-title":"Cytokine & Growth Factor Reviews"},{"key":"10929_CR25","doi-asserted-by":"publisher","first-page":"e24194","DOI":"10.1371\/journal.pone.0024194","volume":"6","author":"F Belleudi","year":"2011","unstructured":"Belleudi, F., Purpura, V., & Torrisi, M. R. (2011). The receptor tyrosine kinase FGFR2b\/KGFR controls early differentiation of human keratinocytes. PLoS One,6, e24194.","journal-title":"PLoS One"},{"key":"10929_CR26","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1038\/nature06403","volume":"450","author":"I Chambers","year":"2007","unstructured":"Chambers, I., et al. (2007). Nanog safeguards pluripotency and mediates germline development. Nature,450, 1230\u20131234.","journal-title":"Nature"},{"key":"10929_CR27","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1172\/JCI200420800","volume":"113","author":"I-K Park","year":"2004","unstructured":"Park, I.-K., Morrison, S. J., & Clarke, M. F. (2004). Bmi1, stem cells, and senescence regulation. The Journal of Clinical Investigation,113, 175\u2013179.","journal-title":"The Journal of Clinical Investigation"},{"key":"10929_CR28","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1101\/gad.224503","volume":"17","author":"AA Avilion","year":"2003","unstructured":"Avilion, A. A., et al. (2003). Multipotent cell lineages in early mouse development depend on SOX2 function. Genes & Development,17, 126\u2013140.","journal-title":"Genes & Development"},{"key":"10929_CR29","unstructured":"The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3\/4 and Sox-2 - PubMed. https:\/\/pubmed.ncbi.nlm.nih.gov\/10409735\/. Accessed 26 Mar 2025."},{"key":"10929_CR30","doi-asserted-by":"publisher","first-page":"14733","DOI":"10.1074\/jbc.270.24.14733","volume":"270","author":"M Sudol","year":"1995","unstructured":"Sudol, M., et al. (1995). Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. Journal of Biological Chemistry,270, 14733\u201314741.","journal-title":"Journal of Biological Chemistry"},{"key":"10929_CR31","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1101\/gad.1165104","volume":"18","author":"MI Koster","year":"2004","unstructured":"Koster, M. I., Kim, S., Mills, A. A., DeMayo, F. J., & Roop, D. R. (2004). p63 is the molecular switch for initiation of an epithelial stratification program. Genes & Development,18, 126\u2013131.","journal-title":"Genes & Development"},{"key":"10929_CR32","doi-asserted-by":"publisher","first-page":"4213","DOI":"10.3390\/ijms23084213","volume":"23","author":"Y Ma","year":"2022","unstructured":"Ma, Y., Lin, Y., Huang, W., & Wang, X. (2022). Direct reprograming of mouse fibroblasts into dermal papilla cells via small molecules. International Journal of Molecular Sciences,23, 4213.","journal-title":"International Journal of Molecular Sciences"},{"key":"10929_CR33","first-page":"667","volume":"40","author":"MH Sawaf","year":"1992","unstructured":"Sawaf, M. H., Goffaux, J. C., Forest, N., & Ouhayoun, J. P. (1992). Expression of cytokeratins during embryogenesis and in pathologic epithelia. Pathologie Biologie,40, 667\u2013672.","journal-title":"Pathologie Biologie"},{"issue":"Pt 5","key":"10929_CR34","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1242\/jcs.109.5.1017","volume":"109","author":"M Michel","year":"1996","unstructured":"Michel, M., et al. (1996). Keratin 19 as a biochemical marker of skin stem cells in vivo and in vitro: Keratin 19 expressing cells are differentially localized in function of anatomic sites, and their number varies with donor age and culture stage. Journal of Cell Science,109(Pt 5), 1017\u20131028.","journal-title":"Journal of Cell Science"},{"key":"10929_CR35","first-page":"322","volume":"45","author":"Z Dai","year":"2025","unstructured":"Dai, Z., et al. (2025). C6TSEDRVAJZ, a combination of small-molecule compounds, induces differentiation of human placental fibroblasts into epithelioid cells in vitro. Nan Fang Yi Ke Da Xue Xue Bao,45, 322\u2013330.","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"10929_CR36","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/0092-8674(80)90406-7","volume":"19","author":"H Hennings","year":"1980","unstructured":"Hennings, H., et al. (1980). Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell,19, 245\u2013254.","journal-title":"Cell"},{"key":"10929_CR37","doi-asserted-by":"publisher","first-page":"e0254731","DOI":"10.1371\/journal.pone.0254731","volume":"16","author":"J Wang","year":"2021","unstructured":"Wang, J., Mongan, M., Zhang, X., & Xia, Y. (2021). Isolation and long-term expansion of murine epidermal stem-like cells. PLoS One,16, e0254731.","journal-title":"PLoS One"},{"key":"10929_CR38","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/j.1749-6632.1988.tb18806.x","volume":"548","author":"SH Yuspa","year":"1988","unstructured":"Yuspa, S. H., et al. (1988). Signal transduction for proliferation and differentiation in keratinocytes. Annals of the New York Academy of Sciences,548, 191\u2013196.","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10929_CR39","doi-asserted-by":"publisher","first-page":"xxxvi","DOI":"10.1046\/j.0022-202X.2004.22233.x","volume":"122","author":"PM Elias","year":"2004","unstructured":"Elias, P. M. (2004). The epidermal permeability barrier: From the early days at Harvard to emerging concepts. The Journal of Investigative Dermatology,122, xxxvi\u2013xxxix.","journal-title":"The Journal of Investigative Dermatology"},{"key":"10929_CR40","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1172\/JCI36183","volume":"119","author":"M Zeisberg","year":"2009","unstructured":"Zeisberg, M., & Neilson, E. G. (2009). Biomarkers for epithelial-mesenchymal transitions. The Journal of Clinical Investigation,119, 1429\u20131437.","journal-title":"The Journal of Clinical Investigation"},{"key":"10929_CR41","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.stem.2014.07.003","volume":"15","author":"Y Buganim","year":"2014","unstructured":"Buganim, Y., et al. (2014). The developmental potential of iPSCs is greatly influenced by reprogramming factor selection. Cell Stem Cell,15, 295\u2013309.","journal-title":"Cell Stem Cell"},{"key":"10929_CR42","doi-asserted-by":"publisher","first-page":"3255","DOI":"10.1073\/pnas.0611376104","volume":"104","author":"MI Koster","year":"2007","unstructured":"Koster, M. I., et al. (2007). p63 induces key target genes required for epidermal morphogenesis. Proceedings of the National Academy of Sciences of the United States of America,104, 3255\u20133260.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10929_CR43","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1016\/j.cell.2016.11.052","volume":"167","author":"A Ocampo","year":"2016","unstructured":"Ocampo, A., et al. (2016). In vivo amelioration of age-associated hallmarks by partial reprogramming. Cell,167, 1719-1733.e12.","journal-title":"Cell"},{"key":"10929_CR44","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1096\/fj.05-4480fje","volume":"20","author":"R Maurelli","year":"2006","unstructured":"Maurelli, R., et al. (2006). Inactivation of p16INK4a (inhibitor of cyclin-dependent kinase 4A) immortalizes primary human keratinocytes by maintaining cells in the stem cell compartment. The FASEB Journal Official Publication of the Federation of American Societies for Experimental Biology,20, 1516\u20131518.","journal-title":"The FASEB Journal Official Publication of the Federation of American Societies for Experimental Biology"},{"key":"10929_CR45","doi-asserted-by":"publisher","first-page":"eaay4353","DOI":"10.1126\/scisignal.aay4353","volume":"13","author":"Y Yin","year":"2020","unstructured":"Yin, Y., & Ornitz, D. M. (2020). FGF9 and FGF10 activate distinct signaling pathways to direct lung epithelial specification and branching. Science Signaling,13, eaay4353.","journal-title":"Science Signaling"},{"key":"10929_CR46","doi-asserted-by":"publisher","first-page":"e52785","DOI":"10.15252\/embr.202152785","volume":"22","author":"HQ Le","year":"2021","unstructured":"Le, H. Q., et al. (2021). An EZH2-dependent transcriptional complex promotes aberrant epithelial remodelling after injury. EMBO Reports,22, e52785.","journal-title":"EMBO Reports"},{"key":"10929_CR47","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/nrm.2016.24","volume":"17","author":"AJ Merrell","year":"2016","unstructured":"Merrell, A. J., & Stanger, B. Z. (2016). Adult cell plasticity in vivo: De-differentiation and transdifferentiation are back in style. Nature Reviews Molecular Cell Biology,17, 413\u2013425.","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"10929_CR48","first-page":"16","volume":"34","author":"L Gao","year":"2020","unstructured":"Gao, L., Wang, J., & Yin, Y. (2020). Interpretation of 2019 international working group on diabetic foot guidelines on the prevention and management of diabetic foot disease. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi Zhongguo Xiufu Chongjian Waike Zazhi Chinese Journal of Reparative and Reconstructive Surgery,34, 16\u201320.","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi Zhongguo Xiufu Chongjian Waike Zazhi Chinese Journal of Reparative and Reconstructive Surgery"},{"key":"10929_CR49","doi-asserted-by":"publisher","unstructured":"Wu, L. et al. (2025). A light-driven electrochromic materials-based nanomotor for H2S-controlled drug release in synergistic cancer chemotherapy immunotherapy. Angewandte Chemie International Edition England, e202503297. https:\/\/doi.org\/10.1002\/anie.202503297","DOI":"10.1002\/anie.202503297"},{"key":"10929_CR50","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1099\/0022-1317-36-1-59","volume":"36","author":"FL Graham","year":"1977","unstructured":"Graham, F. L., Smiley, J., Russell, W. C., & Nairn, R. (1977). Characteristics of a human cell line transformed by DNA from human adenovirus type 5. Journal of General Virology,36, 59\u201374.","journal-title":"Journal of General Virology"}],"container-title":["Stem Cell Reviews and Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-025-10929-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12015-025-10929-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-025-10929-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T18:02:48Z","timestamp":1756922568000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12015-025-10929-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,28]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10929"],"URL":"https:\/\/doi.org\/10.1007\/s12015-025-10929-1","relation":{},"ISSN":["2629-3269","2629-3277"],"issn-type":[{"value":"2629-3269","type":"print"},{"value":"2629-3277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,28]]},"assertion":[{"value":"15 June 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Approval of the research protocol by an Institutional Reviewer Board: \u201cInduce fibroblast reprogramming into keratinocyte-like cells for chronic cutaneous wound injury repair\u201d.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"The study was approved by the Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"December 11, 2024.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Date of Approval"}},{"value":"DW202412101659.The HEK293FT cells used in this study were purchased from the Shanghai Institute of Biochemistry and Cell Biology. According to information provided by the original source, the cell line was originally established with ethical approval, and informed consent was obtained from the donors at the time of tissue collection. The use of these cells in our study complies with institutional and national ethical standards. Further information regarding the ethical provenance of the HEK293FT cell line is available in the references provided on the official website [\n                      \n                      ].","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Registry and the Registration No. of the Study\/Trial"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical Trial Number"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}