{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:44:55Z","timestamp":1785300295640,"version":"3.55.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["530364326"],"award-info":[{"award-number":["530364326"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Rev and Rep"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s12015-025-10957-x","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T03:40:44Z","timestamp":1756179644000},"page":"2637-2653","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Knock Out of miRNA-30a-5p and Reconstitution of the Actin Network Dynamics Partly Restores the Impaired Terminal Erythroid Differentiation during Blood Pharming"],"prefix":"10.1007","volume":"21","author":[{"given":"Jessica","family":"Thiel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duran","family":"S\u00fcr\u00fcn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree C.","family":"Br\u00e4ndle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Teichert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan R.","family":"K\u00fcnzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Friedrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacy","family":"Rzagalinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Shevchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Traikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mirtschink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Wagenf\u00fchr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Buchholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"H\u00f6lig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Tonn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7329-3711","authenticated-orcid":false,"given":"Romy","family":"Kronstein-Wiedemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"10957_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/frhem.2024.1373408","volume":"3","author":"H Hassan","year":"2024","unstructured":"Hassan, H., & Rajput, S. (2024). Blood pharming: Exploring the progress and hurdles in producing in-vitro red blood cells for therapeutic applications. Frontiers in Hematology,3, Article 1373408.","journal-title":"Frontiers in Hematology"},{"issue":"11","key":"10957_CR2","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1016\/j.jcyt.2024.06.009","volume":"26","author":"R Kronstein-Wiedemann","year":"2024","unstructured":"Kronstein-Wiedemann, R., Thiel, J., S\u00fcr\u00fcn, D., et al. (2024). Characterization of immortalized bone marrow erythroid progenitor adult (imBMEP-A)-the first inducible immortalized red blood cell progenitor cell line derived from bone marrow CD71-positive cells. Cytotherapy, 26(11), 1362\u20131373. https:\/\/doi.org\/10.1016\/j.jcyt.2024.06.009","journal-title":"Cytotherapy"},{"issue":"19","key":"10957_CR3","doi-asserted-by":"publisher","first-page":"5071","DOI":"10.1182\/blood-2011-06-362038","volume":"118","author":"MC Giarratana","year":"2011","unstructured":"Giarratana, M. C., Rouard, H., Dumont, A., et al. (2011). Proof of principle for transfusion of in vitro-generated red blood cells [Clinical Trial In Vitro] [in eng]. Blood, 118(19), 5071\u20135079.","journal-title":"Blood"},{"issue":"51","key":"10957_CR4","first-page":"6","volume":"118","author":"AM Toye","year":"2023","unstructured":"Toye, A. M., Kupzig, S., Cogan, N., et al. (2023). The RESTORE clinical trial A update on the RESTORE clinical trial: Manufacture and clinical assessment of cultured red cells [oral presentation]. Vox Sanguinis, 118(51), 6\u2013118.","journal-title":"Vox Sanguinis"},{"issue":"1","key":"10957_CR5","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s13287-023-03367-8","volume":"14","author":"CF Cervellera","year":"2023","unstructured":"Cervellera, C. F., Mazziotta, C., Di Mauro, G., et al. (2023). Immortalized erythroid cells as a novel frontier for in vitro blood production: Current approaches and potential clinical application. Stem Cell Research & Therapy, 14(1), 139.","journal-title":"Stem Cell Research & Therapy"},{"issue":"1","key":"10957_CR6","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.transci.2018.12.015","volume":"58","author":"EE Christaki","year":"2019","unstructured":"Christaki, E. E., Politou, M., Antonelou, M., et al. (2019). Ex vivo generation of transfusable red blood cells from various stem cell sources: A concise revisit of where we are now [in eng]. Transfus Apher Sci, 58(1), 108\u2013112.","journal-title":"Transfus Apher Sci"},{"issue":"1","key":"10957_CR7","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3324\/haematol.2014.108068","volume":"100","author":"I Dorn","year":"2015","unstructured":"Dorn, I., Klich, K., Arauzo-Bravo, M. J., et al. (2015). Erythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin. Haematologica, 100(1), 32\u201341.","journal-title":"Haematologica"},{"issue":"2","key":"10957_CR8","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.stemcr.2023.12.011","volume":"19","author":"N Flosdorf","year":"2024","unstructured":"Flosdorf, N., Bohnke, J., de Toledo, M. A. S., et al. (2024). Proinflammatory phenotype of iPS cell-derived JAK2 V617F megakaryocytes induces fibrosis in 3D in vitro bone marrow niche. Stem Cell Reports,19(2), 224\u2013238.","journal-title":"Stem Cell Reports"},{"issue":"8","key":"10957_CR9","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1002\/stem.2027","volume":"33","author":"S Rouzbeh","year":"2015","unstructured":"Rouzbeh, S., Kobari, L., Cambot, M., et al. (2015). Molecular signature of erythroblast enucleation in human embryonic stem cells. Stem Cells,33(8), 2431\u20132441.","journal-title":"Stem Cells"},{"issue":"1","key":"10957_CR10","doi-asserted-by":"publisher","first-page":"16798","DOI":"10.1038\/s41598-020-73991-4","volume":"10","author":"K Trakarnsanga","year":"2020","unstructured":"Trakarnsanga, K., Tipgomut, C., Metheetrairut, C., et al. (2020). Generation of an immortalised erythroid cell line from Haematopoietic stem cells of a haemoglobin E\/beta-thalassemia patient. Scientific Reports, 10(1), 16798.","journal-title":"Scientific Reports"},{"issue":"8","key":"10957_CR11","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1002\/sctm.17-0057","volume":"6","author":"Y Zhang","year":"2017","unstructured":"Zhang, Y., Wang, C., Wang, L., et al. (2017). Large-Scale ex vivo generation of human red blood cells from cord blood CD34(+) cells [in eng]. Stem Cells Translational Medicine, 6(8), 1698\u20131709.","journal-title":"Stem Cells Translational Medicine"},{"key":"10957_CR12","doi-asserted-by":"publisher","first-page":"14750","DOI":"10.1038\/ncomms14750","volume":"8","author":"K Trakarnsanga","year":"2017","unstructured":"Trakarnsanga, K., Griffiths, R. E., Wilson, M. C., et al. (2017). An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells. Nature Communications, 8, 14750.","journal-title":"Nature Communications"},{"key":"10957_CR13","unstructured":"Gulliver, G. Observations on the sizes and shapes of the red corpuscles of the blood of vertebrates, with drawings of them to a uniform scale, and extended and revised tables of measurements. Proceeding of the Zoological Society of London 1875:474\u2013495."},{"key":"10957_CR14","doi-asserted-by":"publisher","unstructured":"Newton, L. M., Fowler, V. M., & Humbert, P. O. (2024). Erythroblast enucleation at a glance. Journal of Cell Science,\u00a0137, jcs261673 https:\/\/doi.org\/10.1242\/jcs.261673","DOI":"10.1242\/jcs.261673"},{"issue":"2","key":"10957_CR15","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1007\/s12185-022-03386-w","volume":"116","author":"S Soboleva","year":"2022","unstructured":"Soboleva, S., & Miharada, K. (2022). Induction of enucleation in primary and immortalized erythroid cells. International Journal of Hematology, 116(2), 192\u2013198.","journal-title":"International Journal of Hematology"},{"key":"10957_CR16","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.exphem.2021.01.001","volume":"95","author":"V Menon","year":"2021","unstructured":"Menon, V., & Ghaffari, S. (2021). Erythroid enucleation: A gateway into a bloody world. Experimental Hematology,95, 13\u201322.","journal-title":"Experimental Hematology"},{"issue":"17","key":"10957_CR17","doi-asserted-by":"publisher","first-page":"3331","DOI":"10.1182\/blood-2010-03-277426","volume":"116","author":"G Keerthivasan","year":"2010","unstructured":"Keerthivasan, G., Small, S., Liu, H., et al. (2010). Vesicle trafficking plays a novel role in erythroblast enucleation. Blood,116(17), 3331\u20133340.","journal-title":"Blood"},{"issue":"1 Pt 1","key":"10957_CR18","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1083\/jcb.99.1.306","volume":"99","author":"J Ngai","year":"1984","unstructured":"Ngai, J., Capetanaki, Y. G., & Lazarides, E. (1984). Differentiation of murine erythroleukemia cells results in the rapid repression of vimentin gene expression. Journal of Cell Biology,99(1 Pt 1), 306\u2013314.","journal-title":"Journal of Cell Biology"},{"key":"10957_CR19","doi-asserted-by":"publisher","first-page":"100740","DOI":"10.1016\/j.blre.2020.100740","volume":"46","author":"Y Mei","year":"2020","unstructured":"Mei, Y., Liu, Y., & Ji, P. (2020). Understanding terminal erythropoiesis: An update on chromatin condensation, enucleation, and reticulocyte maturation [in eng]. Blood Reviews, 46, 100740.","journal-title":"Blood Reviews"},{"key":"10957_CR20","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.exphem.2020.01.012","volume":"82","author":"R Kronstein-Wiedemann","year":"2020","unstructured":"Kronstein-Wiedemann, R., Klop, O., Thiel, J., et al. (2020). K562 erythroleukemia line as a possible reticulocyte source to culture plasmodium Vivax and its surrogates [in eng]. Experimental Hematology, 82, 8\u201323.","journal-title":"Experimental Hematology"},{"issue":"5","key":"10957_CR21","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1038\/s41375-023-01858-4","volume":"37","author":"R Kronstein-Wiedemann","year":"2023","unstructured":"Kronstein-Wiedemann, R., Blecher, S., Teichert, M., et al. (2023). Novel evidence that the ABO blood group shapes erythropoiesis and results in higher hematocrit for blood group B carriers. Leukemia,37(5), 1126\u20131137.","journal-title":"Leukemia"},{"issue":"1","key":"10957_CR22","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/nbt1047","volume":"23","author":"MC Giarratana","year":"2005","unstructured":"Giarratana, M. C., Kobari, L., Lapillonne, H., et al. (2005). Ex vivo generation of fully mature human red blood cells from hematopoietic stem cells [in eng]. Nature Biotechnology, 23(1), 69\u201374.","journal-title":"Nature Biotechnology"},{"issue":"7","key":"10957_CR23","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1093\/bioinformatics\/btq057","volume":"26","author":"TD Wu","year":"2010","unstructured":"Wu, T. D., & Nacu, S. (2010). Fast and SNP-tolerant detection of complex variants and splicing in short reads. Bioinformatics, 26(7), 873\u2013881.","journal-title":"Bioinformatics"},{"issue":"7","key":"10957_CR24","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","volume":"30","author":"Y Liao","year":"2014","unstructured":"Liao, Y., Smyth, G. K., & Shi, W. (2014). Featurecounts: An efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics,30(7), 923\u2013930.","journal-title":"Bioinformatics"},{"issue":"12","key":"10957_CR25","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M. I., Huber, W., & Anders, S. (2014). Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biology,15(12), 550.","journal-title":"Genome Biology"},{"issue":"4","key":"10957_CR26","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1111\/rssb.12411","volume":"83","author":"N Ignatiadis","year":"2021","unstructured":"Ignatiadis, N., & Huber, W. (2021). Covariate powered cross-weighted multiple testing. Journal of the Royal Statistical Society. Series B, Statistical Methodology,83(4), 720\u2013751.","journal-title":"Journal of the Royal Statistical Society. Series B, Statistical Methodology"},{"key":"10957_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2020.152652","volume":"448","author":"Z Wang","year":"2021","unstructured":"Wang, Z., Karkossa, I., Grosskopf, H., et al. (2021). Comparison of quantitation methods in proteomics to define relevant toxicological information on AhR activation of HepG2 cells by bap. Toxicology,448, Article 152652.","journal-title":"Toxicology"},{"issue":"6","key":"10957_CR28","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.isci.2024.109711","volume":"27","author":"AS Aldehoff","year":"2024","unstructured":"AldehoffAS, Karkossa, I., Goerdeler, C., et al. (2024). Unveiling the dynamics of acetylation and phosphorylation in SGBS and 3T3-L1 adipogenesis. iScience, 27(6), 1097\u20131011.","journal-title":"iScience"},{"issue":"3","key":"10957_CR29","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1021\/acs.jproteome.5b00780","volume":"15","author":"C Bielow","year":"2016","unstructured":"Bielow, C., Mastrobuoni, G., & Kempa, S. (2016). Proteomics quality control: Quality control software for MaxQuant results. Journal of Proteome Research,15(3), 777\u2013787.","journal-title":"Journal of Proteome Research"},{"key":"10957_CR30","unstructured":"Karkossa, I., & Proteomicsr (2023). An analysis pipeline for label-based and label-free proteomics data (1.0.0). Zenodo."},{"issue":"1","key":"10957_CR31","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41592-019-0638-x","volume":"17","author":"V Demichev","year":"2020","unstructured":"Demichev, V., Messner, C. B., Vernardis, S. I., et al. (2020). DIA-NN: Neural networks and interference correction enable deep proteome coverage in high throughput. Nature Methods, 17(1), 41\u201344.","journal-title":"Nature Methods"},{"key":"10957_CR32","doi-asserted-by":"crossref","unstructured":"Howe, B., Umrigar, A., & Tsien, F. Chromosome Preparation from cultured cells. Journal of Visualized Experiments: Jove 2014(83):e50203.","DOI":"10.3791\/50203"},{"issue":"1","key":"10957_CR33","first-page":"27","volume":"1","author":"C O\u2019Connor","year":"2008","unstructured":"O\u2019Connor, C. (2008). Karyotyping for chromosomal abnormalities. Nature Education, 1(1), 27.","journal-title":"Nature Education"},{"key":"10957_CR34","doi-asserted-by":"publisher","first-page":"602483","DOI":"10.4061\/2011\/602483","volume":"2011","author":"V Tirelli","year":"2011","unstructured":"Tirelli, V., Ghinassi, B., Migliaccio, A. R., et al. (2011). Phenotypic definition of the progenitor cells with erythroid differentiation potential present in human adult blood. Stem Cells Int, 2011, 602483.","journal-title":"Stem Cells Int"},{"issue":"47","key":"10957_CR35","doi-asserted-by":"publisher","first-page":"33179","DOI":"10.1074\/jbc.274.47.33179","volume":"274","author":"HQ Sun","year":"1999","unstructured":"Sun, H. Q., Yamamoto, M., Mejillano, M., et al. (1999). Gelsolin, a multifunctional actin regulatory protein. Journal of Biological Chemistry,274(47), 33179\u201333182.","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"10957_CR36","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3324\/haematol.2014.114538","volume":"100","author":"TJ Satchwell","year":"2015","unstructured":"Satchwell, T. J., Hawley, B. R., Bell, A. J., et al. (2015). The cytoskeletal binding domain of band 3 is required for multiprotein complex formation and retention during erythropoiesis. Haematologica, 100(1), 133\u2013142.","journal-title":"Haematologica"},{"issue":"3","key":"10957_CR37","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1158\/0008-5472.CAN-09-3556","volume":"70","author":"CV Dang","year":"2010","unstructured":"Dang, C. V. (2010). Rethinking the warburg effect with Myc micromanaging glutamine metabolism. Cancer Research,70(3), 859\u2013862.","journal-title":"Cancer Research"},{"issue":"20","key":"10957_CR38","doi-asserted-by":"publisher","first-page":"5546","DOI":"10.1158\/1078-0432.CCR-12-0977","volume":"18","author":"DM Miller","year":"2012","unstructured":"Miller, D. M., Thomas, S. D., Islam, A., et al. (2012). C-Myc and cancer metabolism. Clinical Cancer Research,18(20), 5546\u20135553.","journal-title":"Clinical Cancer Research"},{"issue":"50","key":"10957_CR39","doi-asserted-by":"publisher","first-page":"6462","DOI":"10.1038\/onc.2008.312","volume":"27","author":"B Hoffman","year":"2008","unstructured":"Hoffman, B., & Liebermann, D. A. (2008). Apoptotic signaling by c-MYC. Oncogene,27(50), 6462\u20136472.","journal-title":"Oncogene"},{"issue":"20","key":"10957_CR40","doi-asserted-by":"publisher","first-page":"9274","DOI":"10.1016\/S0021-9258(18)67650-1","volume":"261","author":"J Northrop","year":"1986","unstructured":"Northrop, J., Weber, A., Mooseker, M. S., et al. (1986). Different calcium dependence of the capping and cutting activities of villin. Journal of Biological Chemistry,261(20), 9274\u20139281.","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"10957_CR41","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/j.1460-2075.1990.tb08078.x","volume":"9","author":"RD Castillo","year":"1990","unstructured":"Castillo, R. D., Lemaire, A., & Tchakarov, S. (1990). Chromaffin cell scinderin, a novel calcium-dependent actin filament-severing protein. The EMBO Journal,9(1), 43\u201352.","journal-title":"The EMBO Journal"},{"issue":"15","key":"10957_CR42","doi-asserted-by":"publisher","first-page":"4650","DOI":"10.1093\/emboj\/16.15.4650","volume":"16","author":"M Ohtsu","year":"1997","unstructured":"Ohtsu, M., Sakai, N., Fujita, H., et al. (1997). Inhibition of apoptosis by the actin-regulatory protein Gelsolin. Embo Journal, 16(15), 4650\u20134656.","journal-title":"Embo Journal"},{"issue":"12","key":"10957_CR43","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1038\/sj.cdd.4401490","volume":"11","author":"CY Li","year":"2004","unstructured":"Li, C. Y., Zhan, Y. Q., Xu, C. W., et al. (2004). EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of nuclear factor-kappa B. Cell Death and Differentiation, 11(12), 1299\u20131308.","journal-title":"Cell Death and Differentiation"},{"issue":"12","key":"10957_CR44","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1101\/gr.135707.111","volume":"22","author":"MR Tallack","year":"2012","unstructured":"Tallack, M. R., Magor, G. W., Dartigues, B., et al. (2012). Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq. Genome Research,22(12), 2385\u20132398.","journal-title":"Genome Research"},{"issue":"7","key":"10957_CR45","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1038\/sj.leu.2403383","volume":"18","author":"U Testa","year":"2004","unstructured":"Testa, U. (2004). Apoptotic mechanisms in the control of erythropoiesis. Leukemia, 18(7), 1176\u20131199.","journal-title":"Leukemia"},{"issue":"9","key":"10957_CR46","doi-asserted-by":"publisher","first-page":"3837","DOI":"10.1182\/blood.V87.9.3837.bloodjournal8793837","volume":"87","author":"A Benito","year":"1996","unstructured":"Benito, A., Silva, M., Grillot, D., et al. (1996). Apoptosis induced by erythroid differentiation of human leukemia cell lines is inhibited by Bcl-XL. Blood, 87(9), 3837\u20133843.","journal-title":"Blood"},{"issue":"15","key":"10957_CR47","doi-asserted-by":"publisher","first-page":"5680","DOI":"10.1128\/MCB.20.15.5680-5689.2000","volume":"20","author":"E Gottlieb","year":"2000","unstructured":"Gottlieb, E., Vander Heiden, M. G., & Thompson, C. B. (2000). Bcl-x(L) prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis. Molecular and Cellular Biology, 20(15), 5680\u20135689.","journal-title":"Molecular and Cellular Biology"},{"issue":"12","key":"10957_CR48","doi-asserted-by":"publisher","first-page":"2977","DOI":"10.1016\/j.bbamcr.2016.09.012","volume":"1863","author":"M Redza-Dutordoir","year":"2016","unstructured":"Redza-Dutordoir, M., & Averill-Bates, D. A. (2016). Activation of apoptosis signalling pathways by reactive oxygen species. Biochimica Et Biophysica Acta, 1863(12), 2977\u20132992.","journal-title":"Biochimica Et Biophysica Acta"},{"issue":"10","key":"10957_CR49","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.exphem.2016.06.249","volume":"44","author":"B Zhao","year":"2016","unstructured":"Zhao, B., Mei, Y., Yang, J., et al. (2016). Erythropoietin-regulated oxidative stress negatively affects enucleation during terminal erythropoiesis. Experimental Hematology,44(10), 975\u2013981.","journal-title":"Experimental Hematology"}],"container-title":["Stem Cell Reviews and Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-025-10957-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12015-025-10957-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-025-10957-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T04:03:13Z","timestamp":1759896193000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12015-025-10957-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10957"],"URL":"https:\/\/doi.org\/10.1007\/s12015-025-10957-x","relation":{},"ISSN":["2629-3269","2629-3277"],"issn-type":[{"value":"2629-3269","type":"print"},{"value":"2629-3277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]},"assertion":[{"value":"27 July 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"J.T., S.R.K., T.T. and R.K. have filed for a patent application (PCT\/EP2025\/054225) by their institution. The authors declare no further conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}},{"value":"Bone marrow samples and stem cells from mobilized peripheral blood were provided by the Institute for Transfusion Medicine and Immunohematology Frankfurt of the German Red Cross Blood Donation Service Baden-W\u00fcrttemberg\/Hesse, and were used in accordance with the guidelines approved by the Ethics Committee of the Dresden University of Technology [EK138042014]. Written informed consent according to the Declaration of Helsinki was obtained from all donors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Statement"}}]}}