{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:20:54Z","timestamp":1772641254020,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Scientific Research Project of the Health Commission of Guangxi Zhuang Autonomous Region","award":["Z-C20231001"],"award-info":[{"award-number":["Z-C20231001"]}]},{"name":"the Guangxi Natural Science Foundation","award":["2024GXNSFAA010392"],"award-info":[{"award-number":["2024GXNSFAA010392"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Rev and Rep"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s12015-025-11053-w","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T19:18:10Z","timestamp":1769195890000},"page":"1388-1403","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Generation and Exosomal Noncoding RNA Profiling of Down Syndrome-Specific Induced Pluripotent Stem Cells"],"prefix":"10.1007","volume":"22","author":[{"given":"Chunxia","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gengshuo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Sha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chune","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianliang","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minglin","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"issue":"24","key":"11053_CR1","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1056\/NEJMra1706537","volume":"382","author":"BULL M J. Down Syndrome [J]","year":"2020","unstructured":"Bull M J. Down Syndrome [J] (2020). The New England Journal of Medicine, 382(24): 2344\u20132352.","journal-title":"The New England Journal of Medicine"},{"key":"11053_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.980627","volume":"13","author":"Y Song","year":"2022","unstructured":"Song, Y., Jieping, S., Tianshu, Z., et al. (2022). Incidence of Down syndrome by maternal age in Chinese population. Frontiers in Genetics, 13, Article 980627.","journal-title":"Frontiers in Genetics"},{"issue":"11","key":"11053_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta7110","volume":"7","author":"NJ Wald","year":"2003","unstructured":"Wald, N. J., Rodeck, C., Hackshaw, A. K., et al. (2003). First and second trimester antenatal screening for Down\u2019s syndrome: The results of the Serum, Urine and Ultrasound Screening Study (SURUSS). Health Technology Assessment, 7(11), 1\u201377.","journal-title":"Health Technology Assessment"},{"issue":"6","key":"11053_CR4","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1515\/cclm.2011.671","volume":"50","author":"J Canick","year":"2012","unstructured":"Canick, J. (2012). Prenatal screening for trisomy 21: Recent advances and guidelines. Clinical Chemistry and Laboratory Medicine, 50(6), 1003\u20138.","journal-title":"Clinical Chemistry and Laboratory Medicine"},{"issue":"6","key":"11053_CR5","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1111\/j.1471-0528.2002.01394.x","volume":"109","author":"JA Crossley","year":"2002","unstructured":"Crossley, J. A., Aitken, D. A., Cameron, A. D., et al. (2002). Combined ultrasound and biochemical screening for Down\u2019s syndrome in the first trimester: A Scottish multicentre study. BJOG\u202f: An International Journal of Obstetrics and Gynaecology, 109(6), 667\u201376.","journal-title":"BJOG : An International Journal of Obstetrics and Gynaecology"},{"key":"11053_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56040199","author":"AA Simionescu","year":"2020","unstructured":"Simionescu, A. A., & Stanescu, A. M. A. (2020). Missed Down syndrome cases after first trimester false-negative screening-lessons to be learned. Medicina (Kaunas, Lithuania). https:\/\/doi.org\/10.3390\/medicina56040199","journal-title":"Medicina (Kaunas, Lithuania)"},{"issue":"9076","key":"11053_CR7","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/S0140-6736(97)02174-0","volume":"350","author":"YM Lo","year":"1997","unstructured":"Lo, Y. M., Corbetta, N., Chamberlain, P. F., et al. (1997). Presence of fetal DNA in maternal plasma and serum. The Lancet, 350(9076), 485\u20137.","journal-title":"The Lancet"},{"issue":"8","key":"11053_CR8","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1515\/jpm-2021-0204","volume":"49","author":"K Zerres","year":"2021","unstructured":"Zerres, K., RUDNIK-SCH\u00f6NEBORN, S., & Holzgreve, W. (2021). Do non-invasive prenatal tests promote discrimination against people with Down syndrome? What should be done? Journal of Perinatal Medicine, 49(8), 965\u201371.","journal-title":"Journal of Perinatal Medicine"},{"key":"11053_CR9","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/1755-8794-5-57","volume":"5","author":"F JIANG","year":"2012","unstructured":"Jiang, F., Ren, J., Chen, F., et al. (2012). Noninvasive fetal trisomy (NIFTY) test: An advanced noninvasive prenatal diagnosis methodology for fetal autosomal And sex chromosomal Aneuploidies [J]. BMC Medical Genomics, 5, 57.","journal-title":"BMC Medical Genomics"},{"issue":"660","key":"11053_CR10","doi-asserted-by":"publisher","first-page":"298","DOI":"10.3399\/bjgp17X691625","volume":"67","author":"I Rafi","year":"2017","unstructured":"Rafi, I., Hill, M., Hayward, J., et al. (2017). Non-invasive prenatal testing: Use of cell-free fetal DNA in Down syndrome screening. British Journal of General Practice, 67(660), 298\u20139.","journal-title":"British Journal of General Practice"},{"key":"11053_CR11","doi-asserted-by":"publisher","first-page":"18866","DOI":"10.1038\/srep18866","volume":"6","author":"Y YAO","year":"2016","unstructured":"Yao, Y., Liao, Y., Han, M., et al. (2016). Two kinds of common prenatal screening tests for down\u2019s syndrome: A systematic review and meta-analysis [J]. Scientific Reports, 6, 18866.","journal-title":"Scientific Reports"},{"key":"11053_CR12","doi-asserted-by":"crossref","unstructured":"Si-Tayeb K, Idriss, S., Champon, B., et al. (2016). Urine-sample-derived human induced pluripotent stem cells as a model to study PCSK9-mediated autosomal dominant hypercholesterolemia [J] (Vol. 9, pp. 81\u201390). Disease models & mechanisms. 1.","DOI":"10.1242\/dmm.022277"},{"issue":"7","key":"11053_CR13","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/s41576-019-0100-z","volume":"20","author":"RG Rowe","year":"2019","unstructured":"Rowe, R. G., & Daley, G. Q. (2019). Induced pluripotent stem cells in disease modelling and drug discovery. Nature Reviews Genetics, 20(7), 377\u201388.","journal-title":"Nature Reviews Genetics"},{"issue":"R2","key":"11053_CR14","doi-asserted-by":"publisher","first-page":"R89","DOI":"10.1093\/hmg\/ddy186","volume":"27","author":"MS Elitt","year":"2018","unstructured":"Elitt, M. S., Barbar, L., & Tesar, P. J. (2018). Drug screening for human genetic diseases using iPSC models. Human Molecular Genetics, 27(R2), R89-r98.","journal-title":"Human Molecular Genetics"},{"key":"11053_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/cells12060971","author":"H Du","year":"2023","unstructured":"Du, H., Huo, Z., Chen, Y., et al. (2023). Induced pluripotent stem cells and their applications in amyotrophic lateral sclerosis. Cells. https:\/\/doi.org\/10.3390\/cells12060971","journal-title":"Cells"},{"key":"11053_CR16","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/978-1-62703-511-8_7","volume":"1036","author":"JM Churko","year":"2013","unstructured":"Churko, J. M., Burridge, P. W., & Wu, J. C. (2013). Generation of human iPSCs from human peripheral blood mononuclear cells using non-integrative Sendai virus in chemically defined conditions. Methods in Molecular Biology (Clifton, N.J.), 1036, 81\u20138.","journal-title":"Methods in Molecular Biology (Clifton, N.J.)"},{"issue":"1","key":"11053_CR17","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1186\/s13287-019-1369-8","volume":"10","author":"M OU","year":"2019","unstructured":"Ou, M., Li, C., Tang, D., et al. (2019). Genotyping, generation and proteomic profiling of the first human autosomal dominant osteopetrosis type II-specific induced pluripotent stem cells [J]. Stem Cell Research & Therapy, 10(1), 251.","journal-title":"Stem Cell Research & Therapy"},{"issue":"12","key":"11053_CR18","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbl2812336","volume":"28","author":"D Li","year":"2023","unstructured":"Li, D., Ou, M., Dai, G., et al. (2023). Genotypic characterization of a Chinese family with osteogenesis imperfecta and generation of disease-specific induced pluripotent stem cells. Frontiers in Bioscience-Landmark, 28(12), Article 336.","journal-title":"Frontiers in Bioscience-Landmark"},{"issue":"4","key":"11053_CR19","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.yexcr.2012.09.017","volume":"319","author":"SM LU H E, YANG Y C, CHEN","year":"2013","unstructured":"Lu H E, Yang Y C, Chen, S. M., et al. (2013). Modeling neurogenesis impairment in down syndrome with induced pluripotent stem cells from trisomy 21 amniotic fluid cells [J]. Experimental Cell Research, 319(4), 498\u2013505.","journal-title":"Experimental Cell Research"},{"key":"11053_CR20","unstructured":"Momen-Heravi F, & Getting S J Moschos S A. Extracellular Vesicle-based biomarker discovery: opportunities and challenges in the\u2013post-omic era [J]."},{"key":"11053_CR21","doi-asserted-by":"crossref","unstructured":"Kalluri, R., & Lebleu V, S. (2020). The biology, function, and biomedical applications of exosomes [J] (Vol. 367). Science (New York, NY). 6478.","DOI":"10.1126\/science.aau6977"},{"issue":"1","key":"11053_CR22","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12964-022-00853-z","volume":"20","author":"M GHAFOURIAN","year":"2022","unstructured":"Ghafourian, M., Mahdavi, R., Akbari Jonoush Z, et al. (2022). The implications of exosomes in pregnancy: Emerging as new diagnostic markers and therapeutics targets [J]. Cell Communication and Signaling: CCS, 20(1), 51.","journal-title":"Cell Communication and Signaling: CCS"},{"issue":"1","key":"11053_CR23","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12943-021-01352-4","volume":"20","author":"L Zhou","year":"2021","unstructured":"Zhou, L., Wang, W., Wang, F., et al. (2021). Plasma-derived exosomal miR-15a-5p as a promising diagnostic biomarker for early detection of endometrial carcinoma. Molecular Cancer, 20(1), 57.","journal-title":"Molecular Cancer"},{"key":"11053_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering9090459","author":"M Matuli\u0107","year":"2022","unstructured":"Matuli\u0107, M., Gr\u0161kovi\u0107, P., Petrovi\u0107, A., et al. (2022). miRNA in molecular diagnostics. Bioengineering. https:\/\/doi.org\/10.3390\/bioengineering9090459","journal-title":"Bioengineering"},{"issue":"3","key":"11053_CR25","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1111\/jcmm.14886","volume":"24","author":"Y Zhao","year":"2020","unstructured":"Zhao, Y., Yan, Y., Ma, R., et al. (2020). Expression signature of six-snoRNA serves as novel non-invasive biomarker for diagnosis and prognosis prediction of renal clear cell carcinoma. Journal of Cellular and Molecular Medicine, 24(3), 2215\u201328.","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"11053_CR26","doi-asserted-by":"crossref","unstructured":"Li, L., Zhang, Z., Xu, W. (2025). The diagnostic value of serum Exosomal SNORD116 and SNORA21 for NSCLC patients [J]. Clinical & translational oncology: Official publication of the federation of Spanish oncology societies and of the National cancer Institute of Mexico, 27(2): 650\u2013659.","DOI":"10.1007\/s12094-024-03606-1"},{"issue":"9","key":"11053_CR27","doi-asserted-by":"publisher","first-page":"3879","DOI":"10.1093\/nar\/gkq1355","volume":"39","author":"M Ono","year":"2011","unstructured":"Ono, M., Scott, M. S., Yamada, K., et al. (2011). Identification of human miRNA precursors that resemble box C\/D snoRNAs. Nucleic Acids Research, 39(9), 3879\u201391.","journal-title":"Nucleic Acids Research"},{"issue":"9","key":"11053_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000507","volume":"5","author":"MS Scott","year":"2009","unstructured":"Scott, M. S., Avolio, F., Ono, M., et al. (2009). Human miRNA precursors with box H\/ACA snoRNA features. PLoS Computational Biology, 5(9), Article e1000507.","journal-title":"PLoS Computational Biology"},{"issue":"5","key":"11053_CR29","doi-asserted-by":"publisher","first-page":"5451","DOI":"10.1002\/jcp.27486","volume":"234","author":"K SALIMINEJAD","year":"2019","unstructured":"Saliminejad, K., Khorram Khorshid H R, Soleymani Fard, S., et al. (2019). An overview of micrornas: Biology, functions, therapeutics, and analysis methods [J]. Journal of Cellular Physiology, 234(5), 5451\u20135465.","journal-title":"Journal of Cellular Physiology"},{"issue":"1","key":"11053_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-021-02391-2","volume":"22","author":"\u00c9 Fafard-Couture","year":"2021","unstructured":"Fafard-Couture, \u00c9., Bergeron, D., Couture, S., et al. (2021). Annotation of snoRNA abundance across human tissues reveals complex snoRNA-host gene relationships. Genome Biology, 22(1), Article 172.","journal-title":"Genome Biology"},{"key":"11053_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910193","author":"M Wajahat","year":"2021","unstructured":"Wajahat, M., Bracken, C. P., & Orang, A. (2021). Emerging functions for snoRNAs and snoRNA-derived fragments. International Journal of Molecular Sciences. https:\/\/doi.org\/10.3390\/ijms221910193","journal-title":"International Journal of Molecular Sciences"},{"issue":"12","key":"11053_CR32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0020205","volume":"2","author":"MJ Weber","year":"2006","unstructured":"Weber, M. J. (2006). Mammalian small nucleolar RNAs are mobile genetic elements. PLoS Genetics, 2(12), Article e205.","journal-title":"PLoS Genetics"},{"issue":"14","key":"11053_CR33","doi-asserted-by":"publisher","first-page":"6800","DOI":"10.1093\/nar\/gks321","volume":"40","author":"ML BORTOLIN-CAVAILL\u00e9","year":"2012","unstructured":"BORTOLIN-CAVAILL\u00e9, M. L., & CAVAILL\u00e9, J. (2012). The SNORD115 (H\/MBII-52) and SNORD116 (H\/MBII-85) gene clusters at the imprinted Prader-Willi locus generate canonical box C\/D snoRNAs. Nucleic Acids Research, 40(14), 6800\u20137.","journal-title":"Nucleic Acids Research"},{"key":"11053_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2018.00019","volume":"10","author":"H Mcgowan","year":"2018","unstructured":"Mcgowan, H., Mirabella, V. R., Hamod, A., et al. (2018). Hsa-let-7c miRNA regulates synaptic and neuronal function in human neurons. Frontiers in Synaptic Neuroscience, 10, Article 19.","journal-title":"Frontiers in Synaptic Neuroscience"},{"issue":"5\u20136","key":"11053_CR35","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s00335-011-9321-y","volume":"22","author":"X Sturgeon","year":"2011","unstructured":"Sturgeon, X., & Gardiner, K. J. (2011). Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions. Mammalian Genome, 22(5\u20136), 261\u201371.","journal-title":"Mammalian Genome"},{"issue":"6","key":"11053_CR36","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1016\/j.stemcr.2017.05.013","volume":"8","author":"K Kajiwara","year":"2017","unstructured":"Kajiwara, K., Tanemoto, T., Wada, S., et al. (2017). Fetal therapy model of myelomeningocele with three-dimensional skin using amniotic fluid cell-derived induced pluripotent stem cells. Stem Cell Reports, 8(6), 1701\u201313.","journal-title":"Stem Cell Reports"},{"issue":"2","key":"11053_CR37","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1161\/CIRCRESAHA.116.309307","volume":"120","author":"JH Jung","year":"2017","unstructured":"Jung, J. H., Fu, X., & Yang, P. C. (2017). Exosomes generated from iPSC-derivatives: New direction for stem cell therapy in human heart diseases. Circulation Research, 120(2), 407\u201317.","journal-title":"Circulation Research"},{"issue":"2","key":"11053_CR38","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1111\/j.1582-4934.2006.tb00405.x","volume":"10","author":"XB LI","year":"2006","unstructured":"Li, X. B., Zhang Z R, Schluesener H, J., et al. (2006). Role of exosomes in immune regulation [J]. Journal of Cellular and Molecular Medicine, 10(2), 364\u2013375.","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"2","key":"11053_CR39","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.scr.2013.11.008","volume":"12","author":"A COPPOLA","year":"2014","unstructured":"Coppola, A., Romito, A., BoreL, C., et al. (2014). Cardiomyogenesis is controlled by the miR-99a\/let-7c cluster and epigenetic modifications [J]. Stem Cell Research, 12(2), 323\u2013337.","journal-title":"Stem Cell Research"},{"issue":"8","key":"11053_CR40","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1002\/pd.4861","volume":"36","author":"I SVOBODOV\u00e1","year":"2016","unstructured":"SVOBODOV\u00e1, I., KORABE\u010cN\u00e1, M., Calda, P., et al. (2016). Differentially expressed miRNAs in trisomy 21 placentas. Prenatal Diagnosis, 36(8), 775\u201384.","journal-title":"Prenatal Diagnosis"},{"issue":"6","key":"11053_CR41","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/nn.3113","volume":"15","author":"SM LEHMANN","year":"2012","unstructured":"Lehmann, S. M., Kr\u00fcger, C., Park, B., et al. (2012). An unconventional role for mirna: Let-7 activates Toll-like receptor 7 and causes neurodegeneration [J]. Nature Neuroscience, 15(6), 827\u2013835.","journal-title":"Nature Neuroscience"},{"issue":"8","key":"11053_CR42","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1016\/j.celrep.2017.10.084","volume":"21","author":"V BHARAT","year":"2017","unstructured":"Bharat, V., Siebrecht, M., Burk, K., et al. (2017). Capture of dense core vesicles at synapses by JNK-Dependent phosphorylation of Synaptotagmin-4 [J]. Cell Reports, 21(8), 2118\u20132133.","journal-title":"Cell Reports"},{"issue":"6","key":"11053_CR43","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1007\/BF00294247","volume":"79","author":"I Ferrer","year":"1990","unstructured":"Ferrer, I., & Gullotta, F. (1990). Down\u2019s syndrome and Alzheimer\u2019s disease: Dendritic spine counts in the hippocampus. Acta Neuropathologica, 79(6), 680\u20135.","journal-title":"Acta Neuropathologica"},{"issue":"2","key":"11053_CR44","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1007\/s10038-007-0229-z","volume":"53","author":"SW Shaw","year":"2008","unstructured":"Shaw, S. W., Chen, C. P., Cheng, P. J., et al. (2008). Gene dosage change of TPTE and BAGE2 and breakpoint analysis in Robertsonian Down syndrome. Journal of Human Genetics, 53(2), 136\u201343.","journal-title":"Journal of Human Genetics"},{"issue":"2","key":"11053_CR45","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1002\/wrna.1266","volume":"6","author":"M Mcmahon","year":"2015","unstructured":"Mcmahon, M., Contreras, A., & Ruggero, D. (2015). Small RNAs with big implications: New insights into H\/ACA snoRNA function and their role in human disease. Wiley Interdisciplinary Reviews. RNA, 6(2), 173\u201389.","journal-title":"Wiley Interdisciplinary Reviews. RNA"},{"issue":"9","key":"11053_CR46","doi-asserted-by":"publisher","first-page":"3095","DOI":"10.1093\/brain\/awac123","volume":"145","author":"LC T\u00e1BARA","year":"2022","unstructured":"T\u00e1BARA, L. C., Al-Salmi, F., Maroofian, R., et al. (2022). TMEM63C mutations cause mitochondrial morphology defects and underlie hereditary spastic paraplegia. Brain\u202f: A Journal of Neurology, 145(9), 3095\u2013107.","journal-title":"Brain : A Journal of Neurology"},{"key":"11053_CR47","doi-asserted-by":"publisher","DOI":"10.3390\/biology10070609","author":"N Mollo","year":"2021","unstructured":"Mollo, N., Esposito, M., Aurilia, M., et al. (2021). Human trisomic iPSCs from Down syndrome fibroblasts manifest mitochondrial alterations early during neuronal differentiation. Biology. https:\/\/doi.org\/10.3390\/biology10070609","journal-title":"Biology"},{"issue":"6","key":"11053_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2022.166388","volume":"1868","author":"L Xu","year":"2022","unstructured":"Xu, L., Huo, H. Q., Lu, K. Q., et al. (2022). Abnormal mitochondria in Down syndrome iPSC-derived GABAergic interneurons and organoids. Biochimica et biophysica acta Molecular basis of disease, 1868(6), Article 166388.","journal-title":"Biochimica et biophysica acta Molecular basis of disease"}],"container-title":["Stem Cell Reviews and Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-025-11053-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12015-025-11053-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-025-11053-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T11:17:11Z","timestamp":1772623031000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12015-025-11053-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,23]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["11053"],"URL":"https:\/\/doi.org\/10.1007\/s12015-025-11053-w","relation":{},"ISSN":["2629-3269","2629-3277"],"issn-type":[{"value":"2629-3269","type":"print"},{"value":"2629-3277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,23]]},"assertion":[{"value":"4 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The research protocol was approved by the Medical Ethics Committee of the Second Affiliated Hospital of Guilin Medical University (Approval NO.GXKJXM-2023004), and all of the participants provided signed informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"All of the participants provided signed informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}