{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:50:35Z","timestamp":1788958235795,"version":"build-2803163510"},"reference-count":224,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Shenzhen Medical Research Fund","award":["D2402009"],"award-info":[{"award-number":["D2402009"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["2025A1515011298"],"award-info":[{"award-number":["2025A1515011298"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shenzhen Science and Technology Projects","award":["JCYJ 20240813140405008"],"award-info":[{"award-number":["JCYJ 20240813140405008"]}]},{"name":"Medical-Engineering Interdisciplinary Research Foundation of Shenzhen University","award":["2023YG014"],"award-info":[{"award-number":["2023YG014"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stem Cell Rev and Rep"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s12015-026-11080-1","type":"journal-article","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:50:26Z","timestamp":1772859026000},"page":"1683-1711","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stem Cells and their Key Derivatives in Degenerative Musculoskeletal Diseases"],"prefix":"10.1007","volume":"22","author":[{"given":"Nawaz","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynab","family":"Ahmadova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waqas","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayyab","family":"Shafiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiyuan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazim","family":"Muhammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajid","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3638-8102","authenticated-orcid":false,"given":"Li","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,7]]},"reference":[{"issue":"1","key":"11080_CR1","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1186\/s13287-020-01855-9","volume":"11","author":"X Wu","year":"2020","unstructured":"Wu, X., Jiang, J., Gu, Z., Zhang, J., Chen, Y., & Liu, X. (2020). Mesenchymal stromal cell therapies: Immunomodulatory properties and clinical progress. Stem Cell Research & Therapy, 11(1), 345. https:\/\/doi.org\/10.1186\/s13287-020-01855-9","journal-title":"Stem Cell Research & Therapy"},{"issue":"1","key":"11080_CR2","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/s41392-025-02313-9","volume":"10","author":"X Han","year":"2025","unstructured":"Han, X., Liao, R., Li, X., Zhang, C., Huo, S., Qin, L., et al. (2025). Mesenchymal stem cells in treating human diseases: Molecular mechanisms and clinical studies. Signal Transduct Target Ther, 10(1), 262. https:\/\/doi.org\/10.1038\/s41392-025-02313-9","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"11080_CR3","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1186\/s13287-022-02985-y","volume":"13","author":"J Liu","year":"2022","unstructured":"Liu, J., Gao, J., Liang, Z., Gao, C., Niu, Q., Wu, F., et al. (2022). Mesenchymal stem cells and their microenvironment. Stem Cell Research & Therapy, 13(1), 429. https:\/\/doi.org\/10.1186\/s13287-022-02985-y","journal-title":"Stem Cell Research & Therapy"},{"key":"11080_CR4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.2147\/SCCAA.S248519","volume":"13","author":"P Salehinejad","year":"2020","unstructured":"Salehinejad, P., Moshrefi, M., & Eslaminejad, T. (2020). An overview on mesenchymal stem cells derived from extraembryonic tissues: Supplement sources and isolation methods. Stem Cells Cloning, 13, 57\u201365. https:\/\/doi.org\/10.2147\/SCCAA.S248519","journal-title":"Stem Cells Cloning"},{"issue":"10","key":"11080_CR5","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.3390\/cells10102553","volume":"10","author":"V Lu","year":"2021","unstructured":"Lu, V., Tennyson, M., Zhang, J., & Khan, W. (2021). Mesenchymal stem Cell-Derived extracellular vesicles in tendon and ligament Repair-A systematic review of in vivo studies. Cells, 10(10), 2553. https:\/\/doi.org\/10.3390\/cells10102553","journal-title":"Cells"},{"issue":"2","key":"11080_CR6","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s12015-020-10023-8","volume":"17","author":"PPY Lui","year":"2021","unstructured":"Lui, P. P. Y. (2021). Mesenchymal stem cell-derived extracellular vesicles for the promotion of tendon repair-an update of literature. Stem Cell Reviews and Reports, 17(2), 379\u2013389. https:\/\/doi.org\/10.1007\/s12015-020-10023-8","journal-title":"Stem Cell Reviews and Reports"},{"issue":"1","key":"11080_CR7","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1038\/s41420-024-01973-w","volume":"10","author":"J Tang","year":"2024","unstructured":"Tang, J., Wang, X., Lin, X., & Wu, C. (2024). Mesenchymal stem cell-derived extracellular vesicles: A regulator and carrier for targeting bone-related diseases. Cell Death Discov, 10(1), 212. https:\/\/doi.org\/10.1038\/s41420-024-01973-w","journal-title":"Cell Death Discov"},{"issue":"1","key":"11080_CR8","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12951-023-01778-6","volume":"21","author":"J Zou","year":"2023","unstructured":"Zou, J., Yang, W., Cui, W., Li, C., Ma, C., Ji, X., et al. (2023). Therapeutic potential and mechanisms of mesenchymal stem cell-derived exosomes as bioactive materials in tendon\u2013bone healing. Journal of Nanobiotechnology, 21(1), 14. https:\/\/doi.org\/10.1186\/s12951-023-01778-6","journal-title":"Journal of Nanobiotechnology"},{"issue":"1","key":"11080_CR9","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s40001-023-01034-5","volume":"28","author":"MH Gerami","year":"2023","unstructured":"Gerami, M. H., Khorram, R., Rasoolzadegan, S., Mardpour, S., Nakhaei, P., Hashemi, S., et al. (2023). Emerging role of mesenchymal stem\/stromal cells (MSCs) and MSCs-derived exosomes in bone- and joint-associated musculoskeletal disorders: A new frontier. European Journal of Medical Research, 28(1), 86. https:\/\/doi.org\/10.1186\/s40001-023-01034-5","journal-title":"European Journal of Medical Research"},{"issue":"18","key":"11080_CR10","doi-asserted-by":"publisher","first-page":"e2203361","DOI":"10.1002\/adhm.202203361","volume":"12","author":"J Wang","year":"2023","unstructured":"Wang, J., Li, X., Wang, S., Cui, J., Ren, X., & Su, J. (2023). Bone-Targeted exosomes: Strategies and applications. Adv Healthc Mater, 12(18), e2203361. https:\/\/doi.org\/10.1002\/adhm.202203361","journal-title":"Adv Healthc Mater"},{"key":"11080_CR11","doi-asserted-by":"publisher","first-page":"590470","DOI":"10.3389\/fphar.2020.590470","volume":"11","author":"W Wei","year":"2020","unstructured":"Wei, W., Ao, Q., Wang, X., Cao, Y., Liu, Y., Zheng, S. G., et al. (2020). Mesenchymal stem Cell-Derived exosomes: A promising biological tool in nanomedicine. Frontiers in Pharmacology, 11, 590470. https:\/\/doi.org\/10.3389\/fphar.2020.590470","journal-title":"Frontiers in Pharmacology"},{"key":"11080_CR12","doi-asserted-by":"publisher","first-page":"869239","DOI":"10.3389\/fpubh.2022.869239","volume":"10","author":"N Chen","year":"2022","unstructured":"Chen, N., Fong, D. Y. T., & Wong, J. Y. H. (2022). Trends in musculoskeletal rehabilitation needs in China from 1990 to 2030: A bayesian Age-Period-Cohort modeling study. Front Public Health, 10, 869239. https:\/\/doi.org\/10.3389\/fpubh.2022.869239","journal-title":"Front Public Health"},{"issue":"5","key":"11080_CR13","doi-asserted-by":"publisher","first-page":"366","DOI":"10.2471\/BLT.17.204891","volume":"96","author":"AM Briggs","year":"2018","unstructured":"Briggs, A. M., Woolf, A. D., Dreinhofer, K., Homb, N., Hoy, D. G., Kopansky-Giles, D., et al. (2018). Reducing the global burden of musculoskeletal conditions. Bulletin of the World Health Organization, 96(5), 366\u2013368. https:\/\/doi.org\/10.2471\/BLT.17.204891","journal-title":"Bulletin of the World Health Organization"},{"key":"11080_CR14","doi-asserted-by":"publisher","first-page":"1227364","DOI":"10.3389\/fimmu.2023.1227364","volume":"14","author":"C Song","year":"2023","unstructured":"Song, C., Hu, Z., Xu, D., Bian, H., Lv, J., Zhu, X., et al. (2023). STING signaling in inflammaging: A new target against musculoskeletal diseases. Frontiers in Immunology, 14, 1227364. https:\/\/doi.org\/10.3389\/fimmu.2023.1227364","journal-title":"Frontiers in Immunology"},{"key":"11080_CR15","doi-asserted-by":"publisher","first-page":"1524100","DOI":"10.3389\/fphys.2025.1524100","volume":"16","author":"H Sun","year":"2025","unstructured":"Sun, H., Xu, C., Xiong, Z., Liu, M., Ning, X., & Zhuang, Y. (2025). Therapeutic prospects and potential mechanisms of Prdx6: As a novel target in musculoskeletal disorders. Frontiers in Physiology, 16, 1524100. https:\/\/doi.org\/10.3389\/fphys.2025.1524100","journal-title":"Frontiers in Physiology"},{"issue":"6","key":"11080_CR16","doi-asserted-by":"publisher","first-page":"101180","DOI":"10.1016\/j.gendis.2023.101180","volume":"11","author":"X Zhang","year":"2024","unstructured":"Zhang, X., Li, H., Chen, L., Wu, Y., & Li, Y. (2024). NRF2 in age-related musculoskeletal diseases: Role and treatment prospects. Genes Dis, 11(6), 101180. https:\/\/doi.org\/10.1016\/j.gendis.2023.101180","journal-title":"Genes Dis"},{"key":"11080_CR17","doi-asserted-by":"publisher","first-page":"1456796","DOI":"10.3389\/fphar.2024.1456796","volume":"15","author":"YJ Chen","year":"2024","unstructured":"Chen, Y. J., Jia, L. H., Han, T. H., Zhao, Z. H., Yang, J., Xiao, J. P., et al. (2024). Osteoporosis treatment: Current drugs and future developments. Frontiers in Pharmacology, 15, 1456796. https:\/\/doi.org\/10.3389\/fphar.2024.1456796","journal-title":"Frontiers in Pharmacology"},{"key":"11080_CR18","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.bcp.2016.04.010","volume":"117","author":"K Mukherjee","year":"2016","unstructured":"Mukherjee, K., & Chattopadhyay, N. (2016). Pharmacological Inhibition of cathepsin K: A promising novel approach for postmenopausal osteoporosis therapy. Biochemical Pharmacology, 117, 10\u201319. https:\/\/doi.org\/10.1016\/j.bcp.2016.04.010","journal-title":"Biochemical Pharmacology"},{"issue":"9319","key":"11080_CR19","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","volume":"359","author":"SR Cummings","year":"2002","unstructured":"Cummings, S. R., & Melton, L. J. (2002). Epidemiology and outcomes of osteoporotic fractures. Lancet, 359(9319), 1761\u20131767. https:\/\/doi.org\/10.1016\/S0140-6736(02)08657-9","journal-title":"Lancet"},{"key":"11080_CR20","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.bone.2016.11.002","volume":"95","author":"E Paschalis","year":"2017","unstructured":"Paschalis, E., Gamsjaeger, S., Hassler, N., Fahrleitner-Pammer, A., Dobnig, H., Stepan, J., et al. (2017). Vitamin D and calcium supplementation for three years in postmenopausal osteoporosis significantly alters bone mineral and organic matrix quality. Bone, 95, 41\u201346. https:\/\/doi.org\/10.1016\/j.bone.2016.11.002","journal-title":"Bone"},{"issue":"1","key":"11080_CR21","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s00198-015-3386-5","volume":"27","author":"C Weaver","year":"2016","unstructured":"Weaver, C., Alexander, D., Boushey, C., Dawson-Hughes, B., Lappe, J. M., LeBoff, M., et al. (2016). Calcium plus vitamin D supplementation And risk of fractures: An updated meta-analysis from the National osteoporosis foundation. Osteoporosis International, 27(1), 367\u2013376. https:\/\/doi.org\/10.1007\/s00198-015-3386-5","journal-title":"Osteoporosis International"},{"issue":"15","key":"11080_CR22","doi-asserted-by":"publisher","first-page":"5388","DOI":"10.3390\/ijms21155388","volume":"21","author":"G Lombardi","year":"2020","unstructured":"Lombardi, G., Ziemann, E., Banfi, G., & Corbetta, S. (2020). Physical Activity-Dependent regulation of parathyroid hormone and Calcium-Phosphorous metabolism. International Journal of Molecular Sciences, 21(15), 5388. https:\/\/doi.org\/10.3390\/ijms21155388","journal-title":"International Journal of Molecular Sciences"},{"key":"11080_CR23","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jsbmb.2013.09.008","volume":"142","author":"SH Tella","year":"2014","unstructured":"Tella, S. H., & Gallagher, J. C. (2014). Prevention and treatment of postmenopausal osteoporosis. Journal of Steroid Biochemistry and Molecular Biology, 142, 155\u2013170. https:\/\/doi.org\/10.1016\/j.jsbmb.2013.09.008","journal-title":"Journal of Steroid Biochemistry and Molecular Biology"},{"issue":"1","key":"11080_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11914-019-00498-x","volume":"17","author":"NE Lane","year":"2019","unstructured":"Lane, N. E. (2019). Glucocorticoid-induced osteoporosis: New insights into the pathophysiology and treatments. Current Osteoporosis Reports, 17(1), 1\u20137. https:\/\/doi.org\/10.1007\/s11914-019-00498-x","journal-title":"Current Osteoporosis Reports"},{"issue":"9","key":"11080_CR25","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/nrendo.2016.91","volume":"12","author":"MN Weitzmann","year":"2016","unstructured":"Weitzmann, M. N., & Ofotokun, I. (2016). Physiological and pathophysiological bone turnover\u2014role of the immune system. Nature Reviews Endocrinology, 12(9), 518\u2013532. https:\/\/doi.org\/10.1038\/nrendo.2016.91","journal-title":"Nature Reviews Endocrinology"},{"issue":"5","key":"11080_CR26","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1177\/0022034510384626","volume":"90","author":"ET Everett","year":"2011","unstructured":"Everett, E. T. (2011). Fluoride\u2019s effects on the formation of teeth and bones, and the influence of genetics. Journal of Dental Research, 90(5), 552\u2013560. https:\/\/doi.org\/10.1177\/0022034510384626","journal-title":"Journal of Dental Research"},{"issue":"7","key":"11080_CR27","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1001\/jama.2016.11136","volume":"316","author":"PD Miller","year":"2016","unstructured":"Miller, P. D., Hattersley, G., Riis, B. J., Williams, G. C., Lau, E., Russo, L. A., et al. (2016). Effect of abaloparatide vs placebo on new vertebral fractures in postmenopausal women with osteoporosis: A randomized clinical trial. Jama, 316(7), 722\u2013733. https:\/\/doi.org\/10.1001\/jama.2016.11136","journal-title":"Jama"},{"key":"11080_CR28","doi-asserted-by":"publisher","first-page":"111697","DOI":"10.1016\/j.biopha.2021.111697","volume":"139","author":"YH Cheon","year":"2021","unstructured":"Cheon, Y. H., Lee, C. H., Kim, S., Park, G. D., Kwak, S. C., Cho, H. J., et al. (2021). Pitavastatin prevents ovariectomy-induced osteoporosis by regulating osteoclastic resorption and osteoblastic formation. Biomedicine & Pharmacotherapy, 139, 111697. https:\/\/doi.org\/10.1016\/j.biopha.2021.111697","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"6","key":"11080_CR29","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1210\/jc.2011-3045","volume":"97","author":"NB Watts","year":"2012","unstructured":"Watts, N. B., Adler, R. A., Bilezikian, J. P., Drake, M. T., Eastell, R., Orwoll, E. S., et al. (2012). Osteoporosis in men: An endocrine society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism, 97(6), 1802\u20131822. https:\/\/doi.org\/10.1210\/jc.2011-3045","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"1","key":"11080_CR30","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/s41467-018-08097-7","volume":"10","author":"H Chen","year":"2019","unstructured":"Chen, H., Hu, B., Lv, X., Zhu, S., Zhen, G., Wan, M., et al. (2019). Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis. Nature Communications, 10(1), 181. https:\/\/doi.org\/10.1038\/s41467-018-08097-7","journal-title":"Nature Communications"},{"issue":"1","key":"11080_CR31","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1152\/physrev.00066.2017","volume":"99","author":"D Naot","year":"2019","unstructured":"Naot, D., Musson, D. S., & Cornish, J. (2019). The activity of peptides of the calcitonin family in bone. Physiological Reviews, 99(1), 781\u2013805. https:\/\/doi.org\/10.1152\/physrev.00066.2017","journal-title":"Physiological Reviews"},{"issue":"13","key":"11080_CR32","doi-asserted-by":"publisher","first-page":"3002","DOI":"10.3390\/jcm10133002","volume":"10","author":"N Ayub","year":"2021","unstructured":"Ayub, N., Faraj, M., Ghatan, S., Reijers, J. A. A., Napoli, N., & Oei, L. (2021). The treatment gap in osteoporosis. J Clin Med, 10(13), 3002. https:\/\/doi.org\/10.3390\/jcm10133002","journal-title":"J Clin Med"},{"issue":"5","key":"11080_CR33","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1210\/jc.2019-00192","volume":"104","author":"P Barrionuevo","year":"2019","unstructured":"Barrionuevo, P., Kapoor, E., Asi, N., Alahdab, F., Mohammed, K., Benkhadra, K., et al. (2019). Efficacy of Pharmacological therapies for the prevention of fractures in postmenopausal women: A network Meta-Analysis. Journal of Clinical Endocrinology and Metabolism, 104(5), 1623\u20131630. https:\/\/doi.org\/10.1210\/jc.2019-00192","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"11080_CR34","doi-asserted-by":"publisher","first-page":"b5463","DOI":"10.1136\/bmj.b5463","volume":"340","author":"D Group","year":"2010","unstructured":"Group, D. (2010). Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe. The BMJ, 340, b5463. https:\/\/doi.org\/10.1136\/bmj.b5463","journal-title":"The BMJ"},{"issue":"3","key":"11080_CR35","doi-asserted-by":"publisher","first-page":"506","DOI":"10.3390\/nu11030506","volume":"11","author":"HK Choi","year":"2019","unstructured":"Choi, H. K., Kim, G. J., Yoo, H. S., Song, D. H., Chung, K. H., Lee, K. J., et al. (2019). Vitamin C activates osteoblastogenesis and inhibits osteoclastogenesis via Wnt\/beta-Catenin\/ATF4 signaling pathways. Nutrients, 11(3), 506. https:\/\/doi.org\/10.3390\/nu11030506","journal-title":"Nutrients"},{"issue":"5","key":"11080_CR36","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.3390\/nu6051971","volume":"6","author":"J Iwamoto","year":"2014","unstructured":"Iwamoto, J. (2014). Vitamin K(2) therapy for postmenopausal osteoporosis. Nutrients, 6(5), 1971\u20131980. https:\/\/doi.org\/10.3390\/nu6051971","journal-title":"Nutrients"},{"issue":"7","key":"11080_CR37","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/S2213-8587(17)30138-9","volume":"5","author":"HG Bone","year":"2017","unstructured":"Bone, H. G., Wagman, R. B., Brandi, M. L., Brown, J. P., Chapurlat, R., Cummings, S. R., et al. (2017). 10 years of denosumab treatment in postmenopausal women with osteoporosis: Results from the phase 3 randomised FREEDOM trial and open-label extension. Lancet Diabetes Endocrinol, 5(7), 513\u2013523. https:\/\/doi.org\/10.1016\/S2213-8587(17)30138-9","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"9","key":"11080_CR38","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.3390\/ijms21093199","volume":"21","author":"A De Mar\u00e9","year":"2020","unstructured":"De Mar\u00e9, A., D\u2019Haese, P. C., & Verhulst, A. (2020). The role of sclerostin in bone and ectopic calcification. International Journal of Molecular Sciences, 21(9), 3199. https:\/\/doi.org\/10.3390\/ijms21093199","journal-title":"International Journal of Molecular Sciences"},{"issue":"6","key":"11080_CR39","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1111\/bcp.13869","volume":"85","author":"JA Stone","year":"2019","unstructured":"Stone, J. A., McCrea, J. B., Witter, R., Zajic, S., & Stoch, S. A. (2019). Clinical and translational Pharmacology of the cathepsin K inhibitor Odanacatib studied for osteoporosis. British Journal of Clinical Pharmacology, 85(6), 1072\u20131083. https:\/\/doi.org\/10.1111\/bcp.13869","journal-title":"British Journal of Clinical Pharmacology"},{"key":"11080_CR40","doi-asserted-by":"publisher","first-page":"111748","DOI":"10.1016\/j.msec.2020.111748","volume":"120","author":"A Bharadwaz","year":"2021","unstructured":"Bharadwaz, A., & Jayasuriya, A. C. (2021). Osteogenic differentiation cues of the bone morphogenetic protein-9 (BMP-9) and its recent advances in bone tissue regeneration. Materials Science & Engineering. C, Materials for Biological Applications, 120, 111748. https:\/\/doi.org\/10.1016\/j.msec.2020.111748","journal-title":"Materials Science & Engineering. C, Materials for Biological Applications"},{"issue":"1","key":"11080_CR41","doi-asserted-by":"publisher","first-page":"e12956","DOI":"10.1111\/cpr.12956","volume":"54","author":"Y Jiang","year":"2021","unstructured":"Jiang, Y., Zhang, P., Zhang, X., Lv, L., & Zhou, Y. (2021). Advances in mesenchymal stem cell transplantation for the treatment of osteoporosis. Cell Proliferation, 54(1), e12956. https:\/\/doi.org\/10.1111\/cpr.12956","journal-title":"Cell Proliferation"},{"issue":"4","key":"11080_CR42","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/s41584-025-01223-y","volume":"21","author":"D Moulin","year":"2025","unstructured":"Moulin, D., Sellam, J., Berenbaum, F., Guicheux, J., & Boutet, M. A. (2025). The role of the immune system in osteoarthritis: mechanisms, challenges and future directions. Nature Reviews Rheumatology, 21(4), 221\u2013236. https:\/\/doi.org\/10.1038\/s41584-025-01223-y","journal-title":"Nature Reviews Rheumatology"},{"issue":"9","key":"11080_CR43","doi-asserted-by":"publisher","first-page":"e508","DOI":"10.1016\/S2665-9913(23)00163-7","volume":"5","author":"JD Steinmetz","year":"2023","unstructured":"Steinmetz, J. D., Culbreth, G. T., Haile, L. M., Rafferty, Q., Lo, J., Fukutaki, K. G., et al. (2023). Global, regional, and National burden of osteoarthritis, 1990\u20132020 and projections to 2050: A systematic analysis for the global burden of disease study 2021. The Lancet Rheumatology, 5(9), e508\u2013e522. https:\/\/doi.org\/10.1016\/S2665-9913(23)00163-7","journal-title":"The Lancet Rheumatology"},{"issue":"1","key":"11080_CR44","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1186\/s12891-023-06612-6","volume":"24","author":"A Ching","year":"2023","unstructured":"Ching, A., Prior, Y., Parker, J., & Hammond, A. (2023). Biopsychosocial, work-related, and environmental factors affecting work participation in people with osteoarthritis: A systematic review. Bmc Musculoskeletal Disorders, 24(1), 485. https:\/\/doi.org\/10.1186\/s12891-023-06612-6","journal-title":"Bmc Musculoskeletal Disorders"},{"issue":"9","key":"11080_CR45","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1093\/occmed\/kqad132","volume":"73","author":"E Russell","year":"2023","unstructured":"Russell, E., Spencer, S., Atherton, C., Lyall, D., Mackay, D., Stewart, K., et al. (2023). Increased risk of lower limb osteoarthritis among former professional soccer (football) players. Occupational Medicine, 73(9), 547\u2013553. https:\/\/doi.org\/10.1093\/occmed\/kqad132","journal-title":"Occupational Medicine"},{"key":"11080_CR46","doi-asserted-by":"publisher","unstructured":"Migliorini, F., Sch\u00e4fer, L., Bell, A., Weber, C. D., Vecchio, G., & Maffulli, N. (2023). Meniscectomy is associated with a higher rate of osteoarthritis compared to meniscal repair following acute tears: a meta-analysis. Knee Surgery, Sports Traumatology, Arthroscopy, 31(12), 5485\u20135495. https:\/\/doi.org\/10.1007\/s00167-023-07600-y","DOI":"10.1007\/s00167-023-07600-y"},{"issue":"1","key":"11080_CR47","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1186\/s13018-023-04089-6","volume":"18","author":"Y Dong","year":"2023","unstructured":"Dong, Y., Yan, Y., Zhou, J., Zhou, Q., & Wei, H. (2023). Evidence on risk factors for knee osteoarthritis in middle-older aged: A systematic review and meta analysis. J Orthop Surg Res, 18(1), 634. https:\/\/doi.org\/10.1186\/s13018-023-04089-6","journal-title":"J Orthop Surg Res"},{"issue":"6","key":"11080_CR48","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1136\/ard-2022-223640","volume":"82","author":"MC Baker","year":"2023","unstructured":"Baker, M. C., Sheth, K., Lu, R., Lu, D., von Kaeppler, E. P., Bhat, A., et al. (2023). Increased risk of osteoarthritis in patients with atopic disease. Annals of the Rheumatic Diseases, 82(6), 866\u2013872. https:\/\/doi.org\/10.1136\/ard-2022-223640","journal-title":"Annals of the Rheumatic Diseases"},{"key":"11080_CR49","doi-asserted-by":"publisher","first-page":"e39905","DOI":"10.7554\/eLife.39905","volume":"8","author":"Q Wang","year":"2019","unstructured":"Wang, Q., Lepus, C. M., Raghu, H., Reber, L. L., Tsai, M. M., Wong, H. H., et al. (2019). IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis. Elife, 8, e39905. https:\/\/doi.org\/10.7554\/eLife.39905","journal-title":"Elife"},{"issue":"10","key":"11080_CR50","doi-asserted-by":"publisher","first-page":"2134","DOI":"10.1002\/acr.25127","volume":"75","author":"Y Wang","year":"2023","unstructured":"Wang, Y., Li, X., Zhang, Y., Ma, Y., Xu, S., Shuai, Z., et al. (2023). Association of sleep disturbance with catastrophizing and knee pain: Data from the osteoarthritis initiative. Arthritis Care Res (Hoboken), 75(10), 2134\u20132141. https:\/\/doi.org\/10.1002\/acr.25127","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"3","key":"11080_CR51","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1002\/acr.25244","volume":"76","author":"K Aoyagi","year":"2024","unstructured":"Aoyagi, K., Jafarzadeh, S. R., Carlesso, L., Frey Law, L., Lewis, C. E., Nevitt, M., et al. (2024). Mediating effect of pain sensitization on the Paradoxical relation of taking opioids to pain severity in knee osteoarthritis: The multicenter osteoarthritis study. Arthritis Care Res (Hoboken), 76(3), 403\u2013408. https:\/\/doi.org\/10.1002\/acr.25244","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"11080_CR52","doi-asserted-by":"publisher","unstructured":"Dossing, A., Nielsen, S. M., Kroon, F. P., Balsby, I. M., Tarp, S., Kloppenburg, M., et al. (2023). Comparative effectiveness of Pharmacological interventions for hand osteoarthritis: A systematic review and network meta-analysis of randomised trials. RMD Open, 9(3). https:\/\/doi.org\/10.1136\/rmdopen-2023-003030","DOI":"10.1136\/rmdopen-2023-003030"},{"issue":"10414","key":"11080_CR53","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1016\/S0140-6736(23)01572-6","volume":"402","author":"Y Wang","year":"2023","unstructured":"Wang, Y., Jones, G., Keen, H. I., Hill, C. L., Wluka, A. E., Kasza, J., et al. (2023). Methotrexate to treat hand osteoarthritis with synovitis (METHODS): An Australian, multisite, parallel-group, double-blind, randomised, placebo-controlled trial. Lancet, 402(10414), 1764\u20131772. https:\/\/doi.org\/10.1016\/S0140-6736(23)01572-6","journal-title":"Lancet"},{"issue":"3","key":"11080_CR54","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/s41591-024-02822-0","volume":"30","author":"R Wittoek","year":"2024","unstructured":"Wittoek, R., Verbruggen, G., Vanhaverbeke, T., Colman, R., & Elewaut, D. (2024). RANKL Blockade for erosive hand osteoarthritis: A randomized placebo-controlled phase 2a trial. Nature Medicine, 30(3), 829\u2013836. https:\/\/doi.org\/10.1038\/s41591-024-02822-0","journal-title":"Nature Medicine"},{"issue":"1","key":"11080_CR55","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1186\/s13287-023-03359-8","volume":"14","author":"B Sadri","year":"2023","unstructured":"Sadri, B., Hassanzadeh, M., Bagherifard, A., Mohammadi, J., Alikhani, M., Moeinabadi-Bidgoli, K., et al. (2023). Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: A phase II, triple-blinded, placebo controlled, randomized trial. Stem Cell Research & Therapy, 14(1), 162. https:\/\/doi.org\/10.1186\/s13287-023-03359-8","journal-title":"Stem Cell Research & Therapy"},{"issue":"2","key":"11080_CR56","doi-asserted-by":"publisher","first-page":"100342","DOI":"10.1016\/j.ocarto.2023.100342","volume":"5","author":"B Taslakian","year":"2023","unstructured":"Taslakian, B., Miller, L. E., Mabud, T. S., Macaulay, W., Samuels, J., Attur, M., et al. (2023). Genicular artery embolization for treatment of knee osteoarthritis pain: Systematic review and meta-analysis. Osteoarthr Cartil Open, 5(2), 100342. https:\/\/doi.org\/10.1016\/j.ocarto.2023.100342","journal-title":"Osteoarthr Cartil Open"},{"issue":"4","key":"11080_CR57","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1002\/acr2.11610","volume":"6","author":"AR Bihlet","year":"2024","unstructured":"Bihlet, A. R., Balchen, T., Goteti, K., Sonne, J., Ladel, C., Karsdal, M. A., et al. (2024). Safety, Tolerability, and pharmacodynamics of the ADAMTS-5 nanobody M6495: Two phase 1, Single-Center, Double-Blind, Randomized, Placebo-Controlled studies in healthy subjects and patients with osteoarthritis. ACR Open Rheumatol, 6(4), 205\u2013213. https:\/\/doi.org\/10.1002\/acr2.11610","journal-title":"ACR Open Rheumatol"},{"issue":"7","key":"11080_CR58","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.joca.2023.04.001","volume":"31","author":"T Schnitzer","year":"2023","unstructured":"Schnitzer, T., Pueyo, M., Deckx, H., van der Aar, E., Bernard, K., Hatch, S., et al. (2023). Evaluation of S201086\/GLPG1972, an ADAMTS-5 inhibitor, for the treatment of knee osteoarthritis in ROCCELLA: A phase 2 randomized clinical trial. Osteoarthritis Cartilage, 31(7), 985\u2013994. https:\/\/doi.org\/10.1016\/j.joca.2023.04.001","journal-title":"Osteoarthritis Cartilage"},{"issue":"23","key":"11080_CR59","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1097\/01.brs.0000146101.53784.b1","volume":"29","author":"PJ Roughley","year":"2004","unstructured":"Roughley, P. J. (2004). Biology of intervertebral disc aging and degeneration: Involvement of the extracellular matrix. Spine (Phila Pa 1976), 29(23), 2691\u20132699. https:\/\/doi.org\/10.1097\/01.brs.0000146101.53784.b1","journal-title":"Spine (Phila Pa 1976)"},{"issue":"4","key":"11080_CR60","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1002\/ar.23059","volume":"298","author":"ZH Chen","year":"2015","unstructured":"Chen, Z. H., Jin, S. H., Wang, M. Y., Jin, X. L., Lv, C., Deng, Y. F., et al. (2015). Enhanced NLRP3, caspase-1, and IL\u20101\u03b2 levels in degenerate human intervertebral disc and their association with the grades of disc degeneration. The Anatomical Record, 298(4), 720\u2013726. https:\/\/doi.org\/10.1002\/ar.23059","journal-title":"The Anatomical Record"},{"issue":"1","key":"11080_CR61","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/s41572-018-0052-1","volume":"4","author":"JWS Vlaeyen","year":"2018","unstructured":"Vlaeyen, J. W. S., Maher, C. G., Wiech, K., Van Zundert, J., Meloto, C. B., Diatchenko, L., et al. (2018). Low back pain. Nat Rev Dis Primers, 4(1), 52. https:\/\/doi.org\/10.1038\/s41572-018-0052-1","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"11080_CR62","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1136\/annrheumdis-2016-209428","volume":"76","author":"M Dudek","year":"2017","unstructured":"Dudek, M., Yang, N., Ruckshanthi, J. P., Williams, J., Borysiewicz, E., Wang, P., et al. (2017). The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration. Annals of the Rheumatic Diseases, 76(3), 576\u2013584. https:\/\/doi.org\/10.1136\/annrheumdis-2016-209428","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"7","key":"11080_CR63","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1111\/os.13254","volume":"14","author":"J Xin","year":"2022","unstructured":"Xin, J., Wang, Y., Zheng, Z., Wang, S., Na, S., & Zhang, S. (2022). Treatment of intervertebral disc degeneration. Orthop Surg, 14(7), 1271\u20131280. https:\/\/doi.org\/10.1111\/os.13254","journal-title":"Orthop Surg"},{"issue":"12","key":"11080_CR64","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1007\/s00011-024-01954-w","volume":"73","author":"F Liu","year":"2024","unstructured":"Liu, F., Chao, S., Yang, L., Chen, C., Huang, W., Chen, F., et al. (2024). Molecular mechanism of mechanical pressure induced changes in the microenvironment of intervertebral disc degeneration. Inflammation Research, 73(12), 2153\u20132164. https:\/\/doi.org\/10.1007\/s00011-024-01954-w","journal-title":"Inflammation Research"},{"key":"11080_CR65","doi-asserted-by":"publisher","first-page":"1172920","DOI":"10.3389\/fphar.2023.1172920","volume":"14","author":"J Xu","year":"2023","unstructured":"Xu, J., Shao, T., Lou, J., Zhang, J., & Xia, C. (2023). Aging, cell senescence, the pathogenesis and targeted therapies of intervertebral disc degeneration. Frontiers in Pharmacology, 14, 1172920. https:\/\/doi.org\/10.3389\/fphar.2023.1172920","journal-title":"Frontiers in Pharmacology"},{"issue":"9","key":"11080_CR66","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1007\/s00011-023-01784-2","volume":"72","author":"X Chen","year":"2023","unstructured":"Chen, X., Wang, Z., Deng, R., Yan, H., Liu, X., & Kang, R. (2023). Intervertebral disc degeneration and inflammatory microenvironment: expression, pathology, and therapeutic strategies. Inflammation Research, 72(9), 1811\u20131828. https:\/\/doi.org\/10.1007\/s00011-023-01784-2","journal-title":"Inflammation Research"},{"issue":"5","key":"11080_CR67","doi-asserted-by":"publisher","first-page":"3575","DOI":"10.62347\/DSJK1156","volume":"17","author":"Z Meng","year":"2025","unstructured":"Meng, Z., Tan, J., Ouyang, X., Yin, J., & Yan, Y. (2025). The relationship between Biomechanical factors and intervertebral disc degeneration: A review. American Journal of Translational Research, 17(5), 3575. https:\/\/doi.org\/10.62347\/DSJK1156","journal-title":"American Journal of Translational Research"},{"key":"11080_CR68","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3389\/fsurg.2016.00059","volume":"3","author":"NL Martirosyan","year":"2016","unstructured":"Martirosyan, N. L., Patel, A. A., Carotenuto, A., Kalani, M. Y., Belykh, E., Walker, C. T., et al. (2016). Genetic alterations in intervertebral disc disease. Front Surg, 3, 59. https:\/\/doi.org\/10.3389\/fsurg.2016.00059","journal-title":"Front Surg"},{"issue":"9","key":"11080_CR69","doi-asserted-by":"publisher","first-page":"3595","DOI":"10.1096\/fj.14-260323","volume":"29","author":"JL Marques-Rocha","year":"2015","unstructured":"Marques-Rocha, J. L., Samblas, M., Milagro, F. I., Bressan, J., Martinez, J. A., & Marti, A. (2015). Noncoding RNAs, cytokines, and inflammation-related diseases. The Faseb Journal, 29(9), 3595\u20133611. https:\/\/doi.org\/10.1096\/fj.14-260323","journal-title":"The Faseb Journal"},{"key":"11080_CR70","doi-asserted-by":"publisher","unstructured":"Fingeroth, J. M., Forterre, F., Rev\u00e9s, N. V., & Thomas, W. B. (2015). Nonsteroidal Anti-inflammatory Drugs, muscle Relaxants, Opioids, and other treatments for primary and adjunctive medical management of intervertebral disc herniation. Advances in Intervertebral Disc Disease in Dogs and Cats, 186\u2013193. https:\/\/doi.org\/10.1002\/9781118940372.ch24","DOI":"10.1002\/9781118940372.ch24"},{"issue":"5","key":"11080_CR71","doi-asserted-by":"publisher","first-page":"373","DOI":"10.7326\/M15-0934","volume":"163","author":"R Chou","year":"2015","unstructured":"Chou, R., Hashimoto, R., Friedly, J., Fu, R., Bougatsos, C., Dana, T., et al. (2015). Epidural corticosteroid injections for radiculopathy and spinal stenosis: A systematic review and Meta-analysis. Annals of Internal Medicine, 163(5), 373\u2013381. https:\/\/doi.org\/10.7326\/M15-0934","journal-title":"Annals of Internal Medicine"},{"issue":"4","key":"11080_CR72","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1007\/s00264-018-4241-z","volume":"43","author":"K Hashimoto","year":"2019","unstructured":"Hashimoto, K., Aizawa, T., Kanno, H., & Itoi, E. (2019). Adjacent segment degeneration after fusion spinal surgery-a systematic review. International Orthopaedics, 43(4), 987\u2013993. https:\/\/doi.org\/10.1007\/s00264-018-4241-z","journal-title":"International Orthopaedics"},{"issue":"2","key":"11080_CR73","doi-asserted-by":"publisher","first-page":"210","DOI":"10.17305\/bb.2023.9518","volume":"24","author":"M Munda","year":"2024","unstructured":"Munda, M., & Velnar, T. (2024). Stem cell therapy for degenerative disc disease: Bridging the gap between preclinical promise and clinical potential. Biomolecules and Biomedicine, 24(2), 210. https:\/\/doi.org\/10.17305\/bb.2023.9518","journal-title":"Biomolecules and Biomedicine"},{"issue":"3","key":"11080_CR74","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1111\/os.12690","volume":"12","author":"F Xie","year":"2020","unstructured":"Xie, F., Liu, Y. L., Chen, X. Y., Li, Q., Zhong, J., Dai, B. Y., et al. (2020). Role of MicroRNA, LncRNA, and exosomes in the progression of osteoarthritis: A review of recent literature. Orthop Surg, 12(3), 708\u2013716. https:\/\/doi.org\/10.1111\/os.12690","journal-title":"Orthop Surg"},{"issue":"1","key":"11080_CR75","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1186\/s13287-023-03481-7","volume":"14","author":"SH Neo","year":"2023","unstructured":"Neo, S. H., Her, Z., Othman, R., Tee, C. A., Ong, L. C., Wang, Y., et al. (2023). Expansion of human bone marrow-derived mesenchymal stromal cells with enhanced Immunomodulatory properties. Stem Cell Research & Therapy, 14(1), 259. https:\/\/doi.org\/10.1186\/s13287-023-03481-7","journal-title":"Stem Cell Research & Therapy"},{"key":"11080_CR76","doi-asserted-by":"publisher","first-page":"122761","DOI":"10.1016\/j.lfs.2024.122761","volume":"351","author":"A Kostecka","year":"2024","unstructured":"Kostecka, A., Kalamon, N., Skoniecka, A., Koczkowska, M., Skowron, P. M., Piotrowski, A., et al. (2024). Adipose-derived mesenchymal stromal cells in clinical trials: Insights from single-cell studies. Life Sciences, 351, 122761. https:\/\/doi.org\/10.1016\/j.lfs.2024.122761","journal-title":"Life Sciences"},{"issue":"1","key":"11080_CR77","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s13287-021-02222-y","volume":"12","author":"M Mebarki","year":"2021","unstructured":"Mebarki, M., Abadie, C., Larghero, J., & Cras, A. (2021). Human umbilical cord-derived mesenchymal stem\/stromal cells: A promising candidate for the development of advanced therapy medicinal products. Stem Cell Research & Therapy, 12(1), 152. https:\/\/doi.org\/10.1186\/s13287-021-02222-y","journal-title":"Stem Cell Research & Therapy"},{"issue":"4","key":"11080_CR78","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F., Krause, D., et al. (2006). Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement. Cytotherapy, 8(4), 315\u2013317. https:\/\/doi.org\/10.1080\/14653240600855905","journal-title":"Cytotherapy"},{"issue":"1","key":"11080_CR79","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1479-5876-2-18","volume":"2","author":"E Fonsatti","year":"2004","unstructured":"Fonsatti, E., & Maio, M. (2004). Highlights on endoglin (CD105): From basic findings towards clinical applications in human cancer. J Transl Med, 2(1), 18. https:\/\/doi.org\/10.1186\/1479-5876-2-18","journal-title":"J Transl Med"},{"key":"11080_CR80","doi-asserted-by":"publisher","first-page":"1221306","DOI":"10.3389\/fcell.2023.1221306","volume":"11","author":"A Valdivia","year":"2023","unstructured":"Valdivia, A., Avalos, A. M., & Leyton, L. (2023). Thy-1 (CD90)-regulated cell adhesion and migration of mesenchymal cells: Insights into adhesomes, mechanical forces, and signaling pathways. Frontiers in Cell and Developmental Biology, 11, 1221306. https:\/\/doi.org\/10.3389\/fcell.2023.1221306","journal-title":"Frontiers in Cell and Developmental Biology"},{"issue":"1","key":"11080_CR81","doi-asserted-by":"publisher","first-page":"e000610","DOI":"10.1136\/jitc-2020-000610","volume":"8","author":"R Yang","year":"2020","unstructured":"Yang, R., Elsaadi, S., Misund, K., Abdollahi, P., Vandsemb, E. N., Moen, S. H., et al. (2020). Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A Blockade. Journal for Immunotherapy of Cancer, 8(1), e000610. https:\/\/doi.org\/10.1136\/jitc-2020-000610","journal-title":"Journal for Immunotherapy of Cancer"},{"issue":"2","key":"11080_CR82","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/00007890-197108000-00001","volume":"12","author":"A Friedenstein","year":"1971","unstructured":"Friedenstein, A., & Kuralesova, A. I. (1971). Osteogenic precursor cells of bone marrow in radiation chimeras. Transplantation, 12(2), 99\u2013108. https:\/\/doi.org\/10.1097\/00007890-197108000-00001","journal-title":"Transplantation"},{"issue":"3","key":"11080_CR83","first-page":"381","volume":"16","author":"FAPSI Petrakova","year":"1966","unstructured":"Petrakova, F. A. P. S. I. (1966). KV osteogenesis in transplants of bone marrow cells. Journal of Embryology and Experimental Morphology, 16(3), 381\u2013390.","journal-title":"Journal of Embryology and Experimental Morphology"},{"issue":"4","key":"11080_CR84","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1097\/00007890-197404000-00001","volume":"17","author":"AJ Friedenstein","year":"1974","unstructured":"Friedenstein, A. J., Chailakhyan, R. K., Latsinik, N. V., Panasyuk, A. F., & Keiliss-Borok, I. V. (1974). Stromal cells responsible for transferring the microenvironment of the Hemopoietic tissues. Cloning in vitro and retransplantation in vivo. Transplantation, 17(4), 331\u2013340. https:\/\/doi.org\/10.1097\/00007890-197404000-00001","journal-title":"Transplantation"},{"issue":"252","key":"11080_CR85","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1097\/00003086-199003000-00039","volume":"252","author":"KH Wlodarski","year":"1990","unstructured":"Wlodarski, K. H. (1990). Properties and origin of osteoblasts. Clinical Orthopaedics and Related Research, 252(252), 276\u2013293.","journal-title":"Clinical Orthopaedics and Related Research"},{"issue":"5","key":"11080_CR86","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1002\/jor.1100090504","volume":"9","author":"AI Caplan","year":"1991","unstructured":"Caplan, A. I. (1991). Mesenchymal stem cells. Journal of Orthopaedic Research, 9(5), 641\u2013650. https:\/\/doi.org\/10.1002\/jor.1100090504","journal-title":"Journal of Orthopaedic Research"},{"issue":"12","key":"11080_CR87","doi-asserted-by":"publisher","first-page":"3168","DOI":"10.1182\/blood.V79.12.3168.bloodjournal79123168","volume":"79","author":"EL Kittler","year":"1992","unstructured":"Kittler, E. L., McGrath, H., Temeles, D., Crittenden, R. B., Kister, V. K., & Quesenberry, P. J. (1992). Biologic significance of constitutive and subliminal growth factor production by bone marrow stroma. Blood, 79(12), 3168\u20133178.","journal-title":"Blood"},{"issue":"5411","key":"11080_CR88","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1126\/science.284.5411.143","volume":"284","author":"MF Pittenger","year":"1999","unstructured":"Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., et al. (1999). Multilineage potential of adult human mesenchymal stem cells. Science, 284(5411), 143\u2013147. https:\/\/doi.org\/10.1126\/science.284.5411.143","journal-title":"Science"},{"issue":"1","key":"11080_CR89","doi-asserted-by":"publisher","first-page":"752510","DOI":"10.1155\/2015\/752510","volume":"2015","author":"TK Kovach","year":"2015","unstructured":"Kovach, T. K., Dighe, A. S., Lobo, P. I., & Cui, Q. (2015). Interactions between MSCs and immune cells: Implications for bone healing. Journal of Immunology Research, 2015(1), 752510. https:\/\/doi.org\/10.1155\/2015\/752510","journal-title":"Journal of Immunology Research"},{"issue":"1","key":"11080_CR90","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.tmrv.2015.11.004","volume":"30","author":"MJ Fontaine","year":"2016","unstructured":"Fontaine, M. J., Shih, H., Schafer, R., & Pittenger, M. F. (2016). Unraveling the mesenchymal stromal cells\u2019 paracrine Immunomodulatory effects. Transfusion Medicine Reviews, 30(1), 37\u201343. https:\/\/doi.org\/10.1016\/j.tmrv.2015.11.004","journal-title":"Transfusion Medicine Reviews"},{"issue":"11","key":"11080_CR91","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1038\/81395","volume":"6","author":"KW Liechty","year":"2000","unstructured":"Liechty, K. W., MacKenzie, T. C., Shaaban, A. F., Radu, A., Moseley, A. M., Deans, R., et al. (2000). Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nature Medicine, 6(11), 1282\u20131286. https:\/\/doi.org\/10.1038\/81395","journal-title":"Nature Medicine"},{"issue":"9419","key":"11080_CR92","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1016\/S0140-6736(04)16104-7","volume":"363","author":"K Le Blanc","year":"2004","unstructured":"Le Blanc, K., Rasmusson, I., Sundberg, B., Gotherstrom, C., Hassan, M., Uzunel, M., et al. (2004). Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet, 363(9419), 1439\u20131441. https:\/\/doi.org\/10.1016\/S0140-6736(04)16104-7","journal-title":"Lancet"},{"issue":"1","key":"11080_CR93","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12178-014-9254-7","volume":"8","author":"AB Yanke","year":"2015","unstructured":"Yanke, A. B., & Chubinskaya, S. (2015). The state of cartilage regeneration: Current and future technologies. Current Reviews in Musculoskeletal Medicine, 8(1), 1\u20138. https:\/\/doi.org\/10.1007\/s12178-014-9254-7","journal-title":"Current Reviews in Musculoskeletal Medicine"},{"issue":"1","key":"11080_CR94","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/1423-0127-18-49","volume":"18","author":"PM Chen","year":"2011","unstructured":"Chen, P. M., Yen, M. L., Liu, K. J., Sytwu, H. K., & Yen, B. L. (2011). Immunomodulatory properties of human adult and fetal multipotent mesenchymal stem cells. Journal of Biomedical Science, 18(1), 49. https:\/\/doi.org\/10.1186\/1423-0127-18-49","journal-title":"Journal of Biomedical Science"},{"issue":"4","key":"11080_CR95","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1182\/blood-2004-04-1559","volume":"105","author":"S Aggarwal","year":"2005","unstructured":"Aggarwal, S., & Pittenger, M. F. (2005). Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood, 105(4), 1815\u20131822. https:\/\/doi.org\/10.1182\/blood-2004-04-1559","journal-title":"Blood"},{"issue":"10","key":"11080_CR96","doi-asserted-by":"publisher","first-page":"3691","DOI":"10.1182\/blood-2007-02-075481","volume":"110","author":"D Chabannes","year":"2007","unstructured":"Chabannes, D., Hill, M., Merieau, E., Rossignol, J., Brion, R., Soulillou, J. P., et al. (2007). A role for Heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells. Blood, 110(10), 3691\u20133694. https:\/\/doi.org\/10.1182\/blood-2007-02-075481","journal-title":"Blood"},{"issue":"10","key":"11080_CR97","doi-asserted-by":"publisher","first-page":"3838","DOI":"10.1182\/blood.v99.10.3838","volume":"99","author":"M Di Nicola","year":"2002","unstructured":"Di Nicola, M., Carlo-Stella, C., Magni, M., Milanesi, M., Longoni, P. D., Matteucci, P., et al. (2002). Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood, 99(10), 3838\u20133843. https:\/\/doi.org\/10.1182\/blood.v99.10.3838","journal-title":"Blood"},{"issue":"1","key":"11080_CR98","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1182\/blood-2006-02-002246","volume":"109","author":"K Sato","year":"2007","unstructured":"Sato, K., Ozaki, K., Oh, I., Meguro, A., Hatanaka, K., Nagai, T., et al. (2007). Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood, 109(1), 228\u2013234. https:\/\/doi.org\/10.1182\/blood-2006-02-002246","journal-title":"Blood"},{"issue":"8","key":"11080_CR99","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41581-018-0023-5","volume":"14","author":"Y Shi","year":"2018","unstructured":"Shi, Y., Wang, Y., Li, Q., Liu, K., Hou, J., Shao, C., et al. (2018). Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases. Nature Reviews Nephrology, 14(8), 493\u2013507. https:\/\/doi.org\/10.1038\/s41581-018-0023-5","journal-title":"Nature Reviews Nephrology"},{"issue":"2","key":"11080_CR100","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/cdd.2013.158","volume":"21","author":"S Ma","year":"2014","unstructured":"Ma, S., Xie, N., Li, W., Yuan, B., Shi, Y., & Wang, Y. (2014). Immunobiology of mesenchymal stem cells. Cell Death and Differentiation, 21(2), 216\u2013225. https:\/\/doi.org\/10.1038\/cdd.2013.158","journal-title":"Cell Death and Differentiation"},{"issue":"1","key":"11080_CR101","doi-asserted-by":"publisher","first-page":"8973613","DOI":"10.1155\/2018\/8973613","volume":"2018","author":"P Stanko","year":"2018","unstructured":"Stanko, P., Altanerova, U., Jakubechova, J., Repiska, V., & Altaner, C. (2018). Dental mesenchymal stem\/stromal cells and their exosomes. Stem Cells International, 2018(1), 8973613. https:\/\/doi.org\/10.1155\/2018\/8973613","journal-title":"Stem Cells International"},{"issue":"1","key":"11080_CR102","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/s41392-023-01704-0","volume":"9","author":"F Tan","year":"2024","unstructured":"Tan, F., Li, X., Wang, Z., Li, J., Shahzad, K., & Zheng, J. (2024). Clinical applications of stem cell-derived exosomes. Signal Transduct Target Ther, 9(1), 17. https:\/\/doi.org\/10.1038\/s41392-023-01704-0","journal-title":"Signal Transduct Target Ther"},{"issue":"12","key":"11080_CR103","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.3390\/nu17121999","volume":"17","author":"F Cipriani","year":"2025","unstructured":"Cipriani, F., Gnessi, L., Watanabe, M., & Baldelli, R. (2025). Inositols and bone health: Potential therapeutic applications in osteoporosis prevention and treatment. Nutrients, 17(12), 1999. https:\/\/doi.org\/10.3390\/nu17121999","journal-title":"Nutrients"},{"issue":"2","key":"11080_CR104","doi-asserted-by":"publisher","first-page":"360","DOI":"10.3390\/ijms19020360","volume":"19","author":"L Hu","year":"2018","unstructured":"Hu, L., Yin, C., Zhao, F., Ali, A., Ma, J., & Qian, A. (2018). Mesenchymal stem cells: Cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment. International Journal of Molecular Sciences, 19(2), 360. https:\/\/doi.org\/10.3390\/ijms19020360","journal-title":"International Journal of Molecular Sciences"},{"issue":"3","key":"11080_CR105","doi-asserted-by":"publisher","first-page":"197","DOI":"10.2174\/1574888X11666160614103404","volume":"12","author":"W Zahari","year":"2017","unstructured":"Zahari, W., Hashim, S. N., Yusof, M. F., Osman, Z. F., Kannan, T. P., Mokhtar, K. I., et al. (2017). Immunomodulatory effect of cytokines in the differentiation of mesenchymal stem cells: A review. Curr Stem Cell Res Ther, 12(3), 197\u2013206. https:\/\/doi.org\/10.2174\/1574888X11666160614103404","journal-title":"Curr Stem Cell Res Ther"},{"issue":"1","key":"11080_CR106","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s41232-023-00279-1","volume":"43","author":"J Kushioka","year":"2023","unstructured":"Kushioka, J., Chow, S. K., Toya, M., Tsubosaka, M., Shen, H., Gao, Q., et al. (2023). Bone regeneration in inflammation with aging and cell-based Immunomodulatory therapy. Inflamm Regen, 43(1), 29. https:\/\/doi.org\/10.1186\/s41232-023-00279-1","journal-title":"Inflamm Regen"},{"issue":"1","key":"11080_CR107","doi-asserted-by":"publisher","first-page":"4214281","DOI":"10.1155\/2019\/4214281","volume":"2019","author":"H Agata","year":"2019","unstructured":"Agata, H., Sumita, Y., Hidaka, T., Iwatake, M., Kagami, H., & Asahina, I. (2019). Intra-bone marrow administration of mesenchymal stem\/stromal cells is a promising approach for treating osteoporosis. Stem Cells International, 2019(1), 4214281. https:\/\/doi.org\/10.1155\/2019\/4214281","journal-title":"Stem Cells International"},{"issue":"3","key":"11080_CR108","doi-asserted-by":"publisher","first-page":"230949901879953","DOI":"10.1177\/2309499018799534","volume":"26","author":"O Uri","year":"2018","unstructured":"Uri, O., Behrbalk, E., & Folman, Y. (2018). Local implantation of autologous adipose-derived stem cells increases femoral strength and bone density in osteoporotic rats: A randomized controlled animal study. J Orthop Surg (Hong Kong), 26(3), 2309499018799534. https:\/\/doi.org\/10.1177\/2309499018799534","journal-title":"J Orthop Surg (Hong Kong)"},{"issue":"12","key":"11080_CR109","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1016\/j.jcyt.2014.07.009","volume":"16","author":"X Ye","year":"2014","unstructured":"Ye, X., Zhang, P., Xue, S., Xu, Y., Tan, J., & Liu, G. (2014). Adipose-derived stem cells alleviate osteoporosis by enchancing osteogenesis and inhibiting adipogenesis in a rabbit model. Cytotherapy, 16(12), 1643\u20131655. https:\/\/doi.org\/10.1016\/j.jcyt.2014.07.009","journal-title":"Cytotherapy"},{"issue":"8","key":"11080_CR110","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.jcyt.2018.06.008","volume":"20","author":"G Kim","year":"2018","unstructured":"Kim, G., Jin, Y. M., Yu, Y., Kim, H. Y., Jo, S. A., Park, Y. J., et al. (2018). Double intratibial injection of human tonsil-derived mesenchymal stromal cells recovers postmenopausal osteoporotic bone mass. Cytotherapy, 20(8), 1013\u20131027. https:\/\/doi.org\/10.1016\/j.jcyt.2018.06.008","journal-title":"Cytotherapy"},{"issue":"4","key":"11080_CR111","doi-asserted-by":"publisher","first-page":"454","DOI":"10.2174\/1574888X16999201124153000","volume":"16","author":"B Abbaspanah","year":"2021","unstructured":"Abbaspanah, B., Reyhani, S., & Mousavi, S. H. (2021). Applications of umbilical cord derived mesenchymal stem cells in autoimmune and immunological disorders: From literature to clinical practice. Curr Stem Cell Res Ther, 16(4), 454\u2013464. https:\/\/doi.org\/10.2174\/1574888X16999201124153000","journal-title":"Curr Stem Cell Res Ther"},{"key":"11080_CR112","doi-asserted-by":"publisher","first-page":"918565","DOI":"10.3389\/fimmu.2022.918565","volume":"13","author":"ME Fernandez-Santos","year":"2022","unstructured":"Fernandez-Santos, M. E., Garcia-Arranz, M., Andreu, E. J., Garcia-Hernandez, A. M., Lopez-Parra, M., Villaron, E., et al. (2022). Optimization of mesenchymal stromal cell (MSC) manufacturing processes for a better therapeutic outcome. Frontiers in Immunology, 13, 918565. https:\/\/doi.org\/10.3389\/fimmu.2022.918565","journal-title":"Frontiers in Immunology"},{"issue":"1","key":"11080_CR113","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1186\/s13287-020-01920-3","volume":"11","author":"BC Lee","year":"2020","unstructured":"Lee, B. C., & Kang, K. S. (2020). Functional enhancement strategies for Immunomodulation of mesenchymal stem cells and their therapeutic application. Stem Cell Research & Therapy, 11(1), 397. https:\/\/doi.org\/10.1186\/s13287-020-01920-3","journal-title":"Stem Cell Research & Therapy"},{"issue":"9","key":"11080_CR114","doi-asserted-by":"publisher","first-page":"4580","DOI":"10.3390\/ijms23094580","volume":"23","author":"N Raman","year":"2022","unstructured":"Raman, N., Imran, S. A. M., Amin Noordin, A., Zaman, K. B., W., & Nordin, F. (2022). Mechanotransduction in mesenchymal stem cells (MSCs) differentiation: A review. International Journal of Molecular Sciences, 23(9), 4580. https:\/\/doi.org\/10.3390\/ijms23094580","journal-title":"International Journal of Molecular Sciences"},{"key":"11080_CR115","doi-asserted-by":"publisher","unstructured":"Zhang, S., Hu, B., Liu, W., Wang, P., Lv, X., Chen, S. Articular cartilage regeneration: The role of endogenous mesenchymal stem\/progenitor cell recruitment and migration. In Seminars in arthritis and rheumatism, 2020 (Vol. 50, pp. 198\u2013208, Vol. 2): Elsevier. https:\/\/doi.org\/10.1016\/j.semarthrit.2019.11.001","DOI":"10.1016\/j.semarthrit.2019.11.001"},{"issue":"2","key":"11080_CR116","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1002\/art.24265","volume":"60","author":"WH Chen","year":"2009","unstructured":"Chen, W. H., Lai, M. T., Wu, A. T., Wu, C. C., Gelovani, J. G., Lin, C. T., et al. (2009). In vitro stage-specific chondrogenesis of mesenchymal stem cells committed to chondrocytes. Arthritis and Rheumatism, 60(2), 450\u2013459. https:\/\/doi.org\/10.1002\/art.24265","journal-title":"Arthritis and Rheumatism"},{"issue":"3","key":"11080_CR117","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1021\/bm7013203","volume":"9","author":"H Fan","year":"2008","unstructured":"Fan, H., Zhang, C., Li, J., Bi, L., Qin, L., Wu, H., et al. (2008). Gelatin microspheres containing TGF-beta3 enhance the chondrogenesis of mesenchymal stem cells in modified pellet culture. Biomacromolecules, 9(3), 927\u2013934. https:\/\/doi.org\/10.1021\/bm7013203","journal-title":"Biomacromolecules"},{"issue":"8","key":"11080_CR118","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.3390\/ijms21082785","volume":"21","author":"NP Grigull","year":"2020","unstructured":"Grigull, N. P., Redeker, J. I., Schmitt, B., Saller, M. M., Schonitzer, V., & Mayer-Wagner, S. (2020). Chondrogenic potential of pellet culture compared to High-Density culture on a bacterial cellulose hydrogel. International Journal of Molecular Sciences, 21(8), 2785. https:\/\/doi.org\/10.3390\/ijms21082785","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"11080_CR119","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/s42003-020-01520-0","volume":"4","author":"K Futrega","year":"2021","unstructured":"Futrega, K., Robey, P. G., Klein, T. J., Crawford, R. W., & Doran, M. R. (2021). A single day of TGF-beta1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells. Commun Biol, 4(1), 29. https:\/\/doi.org\/10.1038\/s42003-020-01520-0","journal-title":"Commun Biol"},{"issue":"5","key":"11080_CR120","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1007\/s10439-014-1179-1","volume":"43","author":"MS Gupta","year":"2015","unstructured":"Gupta, M. S., & Nicoll, S. B. (2015). Duration of TGF-beta3 exposure impacts the chondrogenic maturation of human MSCs in photocrosslinked carboxymethylcellulose hydrogels. Annals of Biomedical Engineering, 43(5), 1145\u20131157. https:\/\/doi.org\/10.1007\/s10439-014-1179-1","journal-title":"Annals of Biomedical Engineering"},{"issue":"9\u201310","key":"11080_CR121","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1111\/j.1432-0436.2003.07109003.x","volume":"71","author":"B Schmitt","year":"2003","unstructured":"Schmitt, B., Ringe, J., Haupl, T., Notter, M., Manz, R., Burmester, G. R., et al. (2003). BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture. Differentiation, 71(9\u201310), 567\u2013577. https:\/\/doi.org\/10.1111\/j.1432-0436.2003.07109003.x","journal-title":"Differentiation"},{"issue":"4","key":"11080_CR122","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1002\/art.21779","volume":"54","author":"BT Estes","year":"2006","unstructured":"Estes, B. T., Wu, A. W., & Guilak, F. (2006). Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6. Arthritis and Rheumatism, 54(4), 1222\u20131232. https:\/\/doi.org\/10.1002\/art.21779","journal-title":"Arthritis and Rheumatism"},{"issue":"1","key":"11080_CR123","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1186\/s13287-017-0733-9","volume":"8","author":"P Xia","year":"2017","unstructured":"Xia, P., Wang, X., Qu, Y., Lin, Q., Cheng, K., Gao, M., et al. (2017). TGF-\u03b21-induced chondrogenesis of bone marrow mesenchymal stem cells is promoted by low-intensity pulsed ultrasound through the integrin-mTOR signaling pathway. Stem Cell Research & Therapy, 8(1), 281. https:\/\/doi.org\/10.1186\/s13287-017-0733-9","journal-title":"Stem Cell Research & Therapy"},{"issue":"1","key":"11080_CR124","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.bbrc.2008.05.183","volume":"373","author":"YJ Kim","year":"2008","unstructured":"Kim, Y. J., Kim, H. J., & Im, G. I. (2008). PTHrP promotes chondrogenesis and suppresses hypertrophy from both bone marrow-derived and adipose tissue-derived MSCs. Biochemical and Biophysical Research Communications, 373(1), 104\u2013108. https:\/\/doi.org\/10.1016\/j.bbrc.2008.05.183","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"11080_CR125","doi-asserted-by":"publisher","unstructured":"Chang, Y., Wang, X., Li, S., Wang, Y., Jia, C., Yang, X. (2022). Activation of KYN-AHR axis impairs the chondrogenic and chondroprotective effects of human umbilical cord-derived mesenchymal stem cells on osteoarthritis. https:\/\/doi.org\/10.1007\/s13577-022-00811-4","DOI":"10.1007\/s13577-022-00811-4"},{"issue":"9\u201310","key":"11080_CR126","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1089\/ten.TEA.2010.0517","volume":"17","author":"L Wu","year":"2011","unstructured":"Wu, L., Leijten, J. C., Georgi, N., Post, J. N., van Blitterswijk, C. A., & Karperien, M. (2011). Trophic effects of mesenchymal stem cells increase chondrocyte proliferation and matrix formation. Tissue Engineering Part A, 17(9\u201310), 1425\u20131436. https:\/\/doi.org\/10.1089\/ten.TEA.2010.0517","journal-title":"Tissue Engineering Part A"},{"issue":"10","key":"11080_CR127","doi-asserted-by":"publisher","first-page":"e438","DOI":"10.3324\/haematol.2018.214767","volume":"104","author":"TS Cheung","year":"2019","unstructured":"Cheung, T. S., Galleu, A., von Bonin, M., Bornhauser, M., & Dazzi, F. (2019). Apoptotic mesenchymal stromal cells induce prostaglandin E2 in monocytes: Implications for the monitoring of mesenchymal stromal cell activity. Haematologica, 104(10), e438\u2013e441. https:\/\/doi.org\/10.3324\/haematol.2018.214767","journal-title":"Haematologica"},{"issue":"1","key":"11080_CR128","doi-asserted-by":"publisher","first-page":"e70","DOI":"10.1038\/emm.2013.135","volume":"46","author":"DI Cho","year":"2014","unstructured":"Cho, D. I., Kim, M. R., Jeong, H. Y., Jeong, H. C., Jeong, M. H., Yoon, S. H., et al. (2014). Mesenchymal stem cells reciprocally regulate the M1\/M2 balance in mouse bone marrow-derived macrophages. Experimental & Molecular Medicine, 46(1), e70. https:\/\/doi.org\/10.1038\/emm.2013.135","journal-title":"Experimental & Molecular Medicine"},{"key":"11080_CR129","doi-asserted-by":"publisher","unstructured":"Gao, F., Chiu, S. M., Motan, D. A., Zhang, Z., Chen, L., Ji, H. L. (2016). Mesenchymal stem cells and immunomodulation: current status and future prospects. Cell Death Dis, 7(1), e2062. https:\/\/doi.org\/10.1038\/cddis.2015.327","DOI":"10.1038\/cddis.2015.327"},{"issue":"1","key":"11080_CR130","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.pmrj.2013.05.007","volume":"6","author":"J Bashir","year":"2014","unstructured":"Bashir, J., Sherman, A., Lee, H., Kaplan, L., & Hare, J. M. (2014). Mesenchymal stem cell therapies in the treatment of musculoskeletal diseases. PM R, 6(1), 61\u201369. https:\/\/doi.org\/10.1016\/j.pmrj.2013.05.007","journal-title":"PM R"},{"issue":"7","key":"11080_CR131","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1007\/s00402-019-03267-8","volume":"140","author":"F Migliorini","year":"2020","unstructured":"Migliorini, F., Rath, B., Colarossi, G., Driessen, A., Tingart, M., Niewiera, M., et al. (2020). Improved outcomes after mesenchymal stem cells injections for knee osteoarthritis: Results at 12-months follow-up: A systematic review of the literature. Archives of Orthopaedic and Trauma Surgery, 140(7), 853\u2013868. https:\/\/doi.org\/10.1007\/s00402-019-03267-8","journal-title":"Archives of Orthopaedic and Trauma Surgery"},{"issue":"12","key":"11080_CR132","doi-asserted-by":"publisher","first-page":"9939","DOI":"10.3390\/ijms24129939","volume":"24","author":"DC Carneiro","year":"2023","unstructured":"Carneiro, D. C., Araujo, L. T., Santos, G. C., Damasceno, P. K. F., Vieira, J. L., Santos, R. R. D., et al. (2023). Clinical trials with mesenchymal stem cell therapies for osteoarthritis: Challenges in the regeneration of articular cartilage. International Journal of Molecular Sciences, 24(12), 9939. https:\/\/doi.org\/10.3390\/ijms24129939","journal-title":"International Journal of Molecular Sciences"},{"issue":"7","key":"11080_CR133","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1016\/j.arthro.2021.02.045","volume":"37","author":"D Zhao","year":"2021","unstructured":"Zhao, D., Pan, J., Yang, W., Han, Y., Zeng, L., Liang, G., et al. (2021). Intra-articular injections of platelet-rich plasma, adipose mesenchymal stem cells, and bone marrow mesenchymal stem cells associated with better outcomes than hyaluronic acid and saline in knee osteoarthritis: A systematic review and network meta-analysis. Arthroscopy: the Journal of Arthroscopic & Related Surgery, 37(7), 2298\u20132314. https:\/\/doi.org\/10.1016\/j.arthro.2021.02.045","journal-title":"Arthroscopy: the Journal of Arthroscopic & Related Surgery"},{"issue":"6","key":"11080_CR134","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1002\/sctm.18-0122","volume":"8","author":"WS Lee","year":"2019","unstructured":"Lee, W. S., Kim, H. J., Kim, K. I., Kim, G. B., & Jin, W. (2019). Intra-Articular injection of autologous adipose Tissue-Derived mesenchymal stem cells for the treatment of knee osteoarthritis: A phase IIb, Randomized, Placebo-Controlled clinical trial. Stem Cells Transl Med, 8(6), 504\u2013511. https:\/\/doi.org\/10.1002\/sctm.18-0122","journal-title":"Stem Cells Transl Med"},{"issue":"1","key":"11080_CR135","doi-asserted-by":"publisher","first-page":"6235400","DOI":"10.1155\/2022\/6235400","volume":"2022","author":"M Esquijarosa Hechavarria","year":"2022","unstructured":"Esquijarosa Hechavarria, M., & Richard, S. A. (2022). Edifying the focal factors influencing mesenchymal stem cells by the microenvironment of intervertebral disc degeneration in low back pain. Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Soci\u00e9t\u00e9 Canadienne Pour Le Traitement De La Douleur, 2022(1), 6235400. https:\/\/doi.org\/10.1155\/2022\/6235400","journal-title":"Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Soci\u00e9t\u00e9 Canadienne Pour Le Traitement De La Douleur"},{"issue":"23","key":"11080_CR136","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1097\/01.brs.0000146462.92171.7f","volume":"29","author":"MV Risbud","year":"2004","unstructured":"Risbud, M. V., Albert, T. J., Guttapalli, A., Vresilovic, E. J., Hillibrand, A. S., Vaccaro, A. R., et al. (2004). Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: Implications for cell-based transplantation therapy. Spine (Phila Pa 1976), 29(23), 2627\u20132632. https:\/\/doi.org\/10.1097\/01.brs.0000146462.92171.7f","journal-title":"Spine (Phila Pa 1976)"},{"key":"11080_CR137","doi-asserted-by":"publisher","first-page":"591065","DOI":"10.3389\/fimmu.2020.591065","volume":"11","author":"S Dabrowska","year":"2020","unstructured":"Dabrowska, S., Andrzejewska, A., Janowski, M., & Lukomska, B. (2020). Immunomodulatory and regenerative effects of mesenchymal stem cells and extracellular vesicles: Therapeutic outlook for inflammatory and degenerative diseases. Frontiers in Immunology, 11, 591065. https:\/\/doi.org\/10.3389\/fimmu.2020.591065","journal-title":"Frontiers in Immunology"},{"issue":"2","key":"11080_CR138","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1097\/BRS.0b013e31818f8c20","volume":"34","author":"HB Henriksson","year":"2009","unstructured":"Henriksson, H. B., Svanvik, T., Jonsson, M., Hagman, M., Horn, M., Lindahl, A., et al. (2009). Transplantation of human mesenchymal stems cells into intervertebral discs in a xenogeneic Porcine model. Spine, 34(2), 141\u2013148. https:\/\/doi.org\/10.1097\/BRS.0b013e31818f8c20","journal-title":"Spine"},{"issue":"Suppl 4","key":"11080_CR139","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1007\/s00586-008-0750-6","volume":"4","author":"C Hohaus","year":"2008","unstructured":"Hohaus, C., Ganey, T. M., Minkus, Y., & Meisel, H. J. (2008). Cell transplantation in lumbar spine disc degeneration disease. Eur Spine J 17 Suppl, 4(Suppl 4), 492\u2013503. https:\/\/doi.org\/10.1007\/s00586-008-0750-6","journal-title":"Eur Spine J 17 Suppl"},{"issue":"8","key":"11080_CR140","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1097\/BRS.0b013e31816b4619","volume":"33","author":"G Vadal\u00e0","year":"2008","unstructured":"Vadal\u00e0, G., Studer, R. K., Sowa, G., Spiezia, F., Iucu, C., Denaro, V., et al. (2008). Coculture of bone marrow mesenchymal stem cells and nucleus pulposus cells modulate gene expression profile without cell fusion. Spine, 33(8), 870\u2013876. https:\/\/doi.org\/10.1097\/BRS.0b013e31816b4619","journal-title":"Spine"},{"issue":"2","key":"11080_CR141","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3978\/j.issn.2224-4336.2014.03.05","volume":"3","author":"A Wei","year":"2014","unstructured":"Wei, A., Shen, B., Williams, L., & Diwan, A. (2014). Mesenchymal stem cells: Potential application in intervertebral disc regeneration. Transl Pediatr, 3(2), 71\u201390. https:\/\/doi.org\/10.3978\/j.issn.2224-4336.2014.03.05","journal-title":"Transl Pediatr"},{"key":"11080_CR142","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1097\/01.blo.0000146534.31120.cf","volume":"430","author":"YG Zhang","year":"2005","unstructured":"Zhang, Y. G., Guo, X., Xu, P., Kang, L. L., & Li, J. (2005). Bone mesenchymal stem cells transplanted into rabbit intervertebral discs can increase proteoglycans. Clinical Orthopaedics and Related Research (1976\u20132007), 430, 219\u2013226. https:\/\/doi.org\/10.1097\/01.blo.0000146534.31120.cf","journal-title":"Clinical Orthopaedics and Related Research (1976\u20132007)"},{"issue":"5","key":"11080_CR143","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1002\/jor.20584","volume":"26","author":"A Hiyama","year":"2008","unstructured":"Hiyama, A., Mochida, J., Iwashina, T., Omi, H., Watanabe, T., Serigano, K., et al. (2008). Transplantation of mesenchymal stem cells in a canine disc degeneration model. Journal of Orthopaedic Research, 26(5), 589\u2013600. https:\/\/doi.org\/10.1002\/jor.20584","journal-title":"Journal of Orthopaedic Research"},{"issue":"5","key":"11080_CR144","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1007\/s12015-025-10882-z","volume":"21","author":"S Keshavarz","year":"2025","unstructured":"Keshavarz, S., Alavi, C. E., Aghayan, H., Jafari-Shakib, R., & Vojoudi, E. (2025). Advancements in degenerative disc disease treatment: A regenerative medicine approach. Stem Cell Rev Rep, 21(5), 1252\u20131282. https:\/\/doi.org\/10.1007\/s12015-025-10882-z","journal-title":"Stem Cell Rev Rep"},{"issue":"s1","key":"11080_CR145","doi-asserted-by":"publisher","first-page":"40","DOI":"10.14444\/8054","volume":"15","author":"G Vadal\u00e0","year":"2021","unstructured":"Vadal\u00e0, G., Ambrosio, L., Russo, F., Papalia, R., & Denaro, V. (2021). Stem cells and intervertebral disc regeneration overview\u2014What they can and can\u2019t do. International Journal of Spine Surgery, 15(s1), 40\u201353. https:\/\/doi.org\/10.14444\/8054","journal-title":"International Journal of Spine Surgery"},{"issue":"7","key":"11080_CR146","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1002\/term.3216","volume":"15","author":"C Schmitt","year":"2021","unstructured":"Schmitt, C., Radetzki, F., Stirnweiss, A., Mendel, T., Ludtka, C., Friedmann, A., et al. (2021). Long-term pre-clinical evaluation of an injectable Chitosan nanocellulose hydrogel with encapsulated adipose-derived stem cells in an ovine model for IVD regeneration. Journal of Tissue Engineering and Regenerative Medicine, 15(7), 660\u2013673. https:\/\/doi.org\/10.1002\/term.3216","journal-title":"Journal of Tissue Engineering and Regenerative Medicine"},{"issue":"8","key":"11080_CR147","doi-asserted-by":"publisher","first-page":"4248","DOI":"10.3390\/ijms22084248","volume":"22","author":"A Friedmann","year":"2021","unstructured":"Friedmann, A., Baertel, A., Schmitt, C., Ludtka, C., Milosevic, J., Meisel, H. J., et al. (2021). Intervertebral disc regeneration injection of a Cell-Loaded collagen hydrogel in a sheep model. International Journal of Molecular Sciences, 22(8), 4248. https:\/\/doi.org\/10.3390\/ijms22084248","journal-title":"International Journal of Molecular Sciences"},{"issue":"2","key":"11080_CR148","doi-asserted-by":"publisher","first-page":"e10447","DOI":"10.1002\/btm2.10447","volume":"8","author":"CY Ho","year":"2023","unstructured":"Ho, C. Y., Wang, C. C., Wu, T. C., Kuan, C. H., Liu, Y. C., & Wang, T. W. (2023). Peptide-functionalized double network hydrogel with compressible shape memory effect for intervertebral disc regeneration. Bioeng Transl Med, 8(2), e10447. https:\/\/doi.org\/10.1002\/btm2.10447","journal-title":"Bioeng Transl Med"},{"key":"11080_CR149","doi-asserted-by":"publisher","first-page":"112343","DOI":"10.1016\/j.msec.2021.112343","volume":"128","author":"Y Wang","year":"2021","unstructured":"Wang, Y., Zhang, Y., Chen, K., Shao, F., Wu, Y., Guo, C., et al. (2021). Injectable nanostructured colloidal gels resembling native nucleus pulposus as carriers of mesenchymal stem cells for the repair of degenerated intervertebral discs. Materials Science and Engineering: C, 128, 112343. https:\/\/doi.org\/10.1016\/j.msec.2021.112343","journal-title":"Materials Science and Engineering: C"},{"key":"11080_CR150","doi-asserted-by":"crossref","unstructured":"Asti, A., & Gioglio, L. (2014). Natural and synthetic biodegradable polymers: Different scaffolds for cell expansion and tissue formation. International Journal of Artificial Organs, 37(3), 187\u2013205. https:\/\/doi.org\/10.530\/ijao.5000307","DOI":"10.5301\/ijao.5000307"},{"key":"11080_CR151","doi-asserted-by":"publisher","unstructured":"Liu, J., Song, Q., Yin, W., Li, C., An, N., Le, Y. Bioactive scaffolds for tissue engineering: a review of decellularized extracellular matrix applications and innovations. In Exploration, 2025 (Vol. 5, p. 20230078, Vol. 1): Wiley Online Library. https:\/\/doi.org\/10.1002\/EXP.20230078","DOI":"10.1002\/EXP.20230078"},{"issue":"7","key":"11080_CR152","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1097\/TP.0b013e3182298a15","volume":"92","author":"L Orozco","year":"2011","unstructured":"Orozco, L., Soler, R., Morera, C., Alberca, M., Sanchez, A., & Garcia-Sancho, J. (2011). Intervertebral disc repair by autologous mesenchymal bone marrow cells: A pilot study. Transplantation, 92(7), 822\u2013828. https:\/\/doi.org\/10.1097\/TP.0b013e3182298a15","journal-title":"Transplantation"},{"issue":"1","key":"11080_CR153","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1089\/scd.2006.15.136","volume":"15","author":"SM Haufe","year":"2006","unstructured":"Haufe, S. M., & Mork, A. R. (2006). Intradiscal injection of hematopoietic stem cells in an attempt to rejuvenate the intervertebral discs. Stem Cells and Development, 15(1), 136\u2013137. https:\/\/doi.org\/10.1089\/scd.2006.15.136","journal-title":"Stem Cells and Development"},{"issue":"8","key":"11080_CR154","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1097\/TP.0000000000001484","volume":"101","author":"DC Noriega","year":"2017","unstructured":"Noriega, D. C., Ardura, F., Hernandez-Ramajo, R., Martin-Ferrero, M. A., Sanchez-Lite, I., Toribio, B., et al. (2017). Intervertebral disc repair by allogeneic mesenchymal bone marrow cells: A randomized controlled trial. Transplantation, 101(8), 1945\u20131951. https:\/\/doi.org\/10.1097\/TP.0000000000001484","journal-title":"Transplantation"},{"key":"11080_CR155","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ymeth.2015.09.015","volume":"99","author":"SM Richardson","year":"2016","unstructured":"Richardson, S. M., Kalamegam, G., Pushparaj, P. N., Matta, C., Memic, A., Khademhosseini, A., et al. (2016). Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration. Methods, 99, 69\u201380. https:\/\/doi.org\/10.1016\/j.ymeth.2015.09.015","journal-title":"Methods"},{"issue":"1","key":"11080_CR156","doi-asserted-by":"publisher","first-page":"e1234","DOI":"10.1002\/jsp2.1234","volume":"6","author":"DL Poletto","year":"2023","unstructured":"Poletto, D. L., Crowley, J. D., Tanglay, O., Walsh, W. R., & Pelletier, M. H. (2023). Preclinical in vivo animal models of intervertebral disc degeneration. Part 1: A systematic review. JOR Spine, 6(1), e1234. https:\/\/doi.org\/10.1002\/jsp2.1234","journal-title":"JOR Spine"},{"issue":"3","key":"11080_CR157","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1002\/jbm.a.35243","volume":"103","author":"Y Liu","year":"2015","unstructured":"Liu, Y., Fu, S., Rahaman, M. N., Mao, J. J., & Bal, B. S. (2015). Native nucleus pulposus tissue matrix promotes notochordal differentiation of human induced pluripotent stem cells with potential for treating intervertebral disc degeneration. Journal of Biomedical Materials Research. Part A, 103(3), 1053\u20131059. https:\/\/doi.org\/10.1002\/jbm.a.35243","journal-title":"Journal of Biomedical Materials Research. Part A"},{"issue":"4","key":"11080_CR158","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3390\/bioengineering9040148","volume":"9","author":"FJ Lyu","year":"2022","unstructured":"Lyu, F. J. (2022). Impact of microenvironmental changes during degeneration on intervertebral disc progenitor cells: A comparison with mesenchymal stem cells. Bioengineering (Basel), 9(4), 148. https:\/\/doi.org\/10.3390\/bioengineering9040148","journal-title":"Bioengineering (Basel)"},{"key":"11080_CR159","doi-asserted-by":"publisher","first-page":"1137199","DOI":"10.3389\/fbioe.2023.1137199","volume":"11","author":"R Deng","year":"2023","unstructured":"Deng, R., Kang, R., Jin, X., Wang, Z., Liu, X., Wang, Q., et al. (2023). Mechanical stimulation promotes MSCs healing the lesion of intervertebral disc annulus fibrosus. Frontiers in Bioengineering and Biotechnology, 11, 1137199. https:\/\/doi.org\/10.3389\/fbioe.2023.1137199","journal-title":"Frontiers in Bioengineering and Biotechnology"},{"issue":"10","key":"11080_CR160","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1056\/NEJMra1704286","volume":"379","author":"R Shah","year":"2018","unstructured":"Shah, R., Patel, T., & Freedman, J. E. (2018). Circulating extracellular vesicles in human disease. New England Journal of Medicine, 379(10), 958\u2013966. https:\/\/doi.org\/10.1056\/NEJMra1704286","journal-title":"New England Journal of Medicine"},{"issue":"5","key":"11080_CR161","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/s41590-021-00899-0","volume":"22","author":"C Marar","year":"2021","unstructured":"Marar, C., Starich, B., & Wirtz, D. (2021). Extracellular vesicles in Immunomodulation and tumor progression. Nature Immunology, 22(5), 560\u2013570. https:\/\/doi.org\/10.1038\/s41590-021-00899-0","journal-title":"Nature Immunology"},{"key":"11080_CR162","doi-asserted-by":"publisher","first-page":"105692","DOI":"10.1016\/j.phrs.2021.105692","volume":"170","author":"L Ohayon","year":"2021","unstructured":"Ohayon, L., Zhang, X., & Dutta, P. (2021). The role of extracellular vesicles in regulating local and systemic inflammation in cardiovascular disease. Pharmacological Research, 170, 105692. https:\/\/doi.org\/10.1016\/j.phrs.2021.105692","journal-title":"Pharmacological Research"},{"issue":"1","key":"11080_CR163","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s43556-025-00277-4","volume":"6","author":"Y Wang","year":"2025","unstructured":"Wang, Y., Wang, H., Tan, J., Cao, Z., Wang, Q., Wang, H., et al. (2025). Therapeutic effect of mesenchymal stem cells and their derived exosomes in diseases. Molecular Biomedicine, 6(1), 34. https:\/\/doi.org\/10.1186\/s43556-025-00277-4","journal-title":"Molecular Biomedicine"},{"issue":"1","key":"11080_CR164","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12964-015-0124-8","volume":"14","author":"L Ramos","year":"2016","unstructured":"Ramos, L., S\u00e1nchez-Abarca, T., Munti\u00f3n, L. I., Preciado, S., Puig, S., L\u00f3pez-Ruano, N., G., et al. (2016). MSC surface markers (CD44, CD73, and CD90) can identify human MSC-derived extracellular vesicles by conventional flow cytometry. Cell Communication and Signaling, 14(1), 2. https:\/\/doi.org\/10.1186\/s12964-015-0124-8","journal-title":"Cell Communication and Signaling"},{"issue":"6","key":"11080_CR165","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.2217\/rme-2019-0136","volume":"15","author":"S Wang","year":"2020","unstructured":"Wang, S., Li, L., Liu, T., Jiang, W., & Hu, X. (2020). miR-19a\/19b-loaded exosomes in combination with mesenchymal stem cell transplantation in a preclinical model of myocardial infarction. Regenerative Medicine, 15(6), 1749\u20131759. https:\/\/doi.org\/10.2217\/rme-2019-0136","journal-title":"Regenerative Medicine"},{"issue":"5","key":"11080_CR166","doi-asserted-by":"publisher","first-page":"757","DOI":"10.14670\/HH-18-816","volume":"40","author":"H Zhou","year":"2025","unstructured":"Zhou, H., Wu, Y., Xue, J., & Yu, L. (2025). Ameliorative effects of HGF-overexpressed exosomes derived from ADMSCs on oxidative stress in hepatic fibrosis. Histology and Histopathology, 40(5), 757\u2013772. https:\/\/doi.org\/10.14670\/HH-18-816","journal-title":"Histology and Histopathology"},{"issue":"1","key":"11080_CR167","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1186\/s13287-020-02032-8","volume":"11","author":"ZG Wang","year":"2020","unstructured":"Wang, Z. G., He, Z. Y., Liang, S., Yang, Q., Cheng, P., & Chen, A. M. (2020). Comprehensive proteomic analysis of exosomes derived from human bone marrow, adipose tissue, and umbilical cord mesenchymal stem cells. Stem Cell Research & Therapy, 11(1), 511. https:\/\/doi.org\/10.1186\/s13287-020-02032-8","journal-title":"Stem Cell Research & Therapy"},{"issue":"584","key":"11080_CR168","doi-asserted-by":"publisher","first-page":"eabb0202","DOI":"10.1126\/scitranslmed.abb0202","volume":"13","author":"Q Li","year":"2021","unstructured":"Li, Q., Xu, Y., Lv, K., Wang, Y., Zhong, Z., Xiao, C., et al. (2021). Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates. Science Translational Medicine, 13(584), eabb0202. https:\/\/doi.org\/10.1126\/scitranslmed.abb0202","journal-title":"Science Translational Medicine"},{"issue":"1","key":"11080_CR169","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13287-020-1550-0","volume":"11","author":"M Shao","year":"2020","unstructured":"Shao, M., Xu, Q., Wu, Z., Chen, Y., Shu, Y., Cao, X., et al. (2020). Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate IL-6-induced acute liver injury through miR-455-3p. Stem Cell Research & Therapy, 11(1), 37. https:\/\/doi.org\/10.1186\/s13287-020-1550-0","journal-title":"Stem Cell Research & Therapy"},{"issue":"1","key":"11080_CR170","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1186\/s13287-020-01823-3","volume":"11","author":"GM Lu","year":"2020","unstructured":"Lu, G. M., Rong, Y. X., Liang, Z. J., Hunag, D. L., Ma, Y. F., Luo, Z. Z., et al. (2020). Multiomics global landscape of stemness-related gene clusters in adipose-derived mesenchymal stem cells. Stem Cell Research & Therapy, 11(1), 310. https:\/\/doi.org\/10.1186\/s13287-020-01823-3","journal-title":"Stem Cell Research & Therapy"},{"issue":"1","key":"11080_CR171","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1186\/s12951-024-02779-9","volume":"22","author":"B Zeng","year":"2024","unstructured":"Zeng, B., Li, Y., Khan, N., Su, A., Yang, Y., Mi, P., et al. (2024). Yin-Yang: Two sides of extracellular vesicles in inflammatory diseases. J Nanobiotechnology, 22(1), 514. https:\/\/doi.org\/10.1186\/s12951-024-02779-9","journal-title":"J Nanobiotechnology"},{"key":"11080_CR172","doi-asserted-by":"publisher","first-page":"1047094","DOI":"10.3389\/fcell.2022.1047094","volume":"10","author":"BAA Koga","year":"2023","unstructured":"Koga, B. A. A., Fernandes, L. A., Fratini, P., Sogayar, M. C., & Carreira, A. C. O. (2023). Role of MSC-derived small extracellular vesicles in tissue repair and regeneration. Frontiers in Cell and Developmental Biology, 10, 1047094. https:\/\/doi.org\/10.3389\/fcell.2022.1047094","journal-title":"Frontiers in Cell and Developmental Biology"},{"issue":"4","key":"11080_CR173","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.3390\/biomedicines11041231","volume":"11","author":"C Ulpiano","year":"2023","unstructured":"Ulpiano, C., da Silva, C. L., & Monteiro, G. A. (2023). Bioengineered mesenchymal-stromal-cell-derived extracellular vesicles as an improved drug delivery system: Methods and applications. Biomedicines, 11(4), 1231. https:\/\/doi.org\/10.3390\/biomedicines11041231","journal-title":"Biomedicines"},{"issue":"9","key":"11080_CR174","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1007\/s00198-015-3154-6","volume":"26","author":"A Oden","year":"2015","unstructured":"Oden, A., McCloskey, E. V., Kanis, J. A., Harvey, N. C., & Johansson, H. (2015). Burden of high fracture probability worldwide: Secular increases 2010\u20132040. Osteoporosis International, 26(9), 2243\u20132248. https:\/\/doi.org\/10.1007\/s00198-015-3154-6","journal-title":"Osteoporosis International"},{"key":"11080_CR175","doi-asserted-by":"publisher","first-page":"119204","DOI":"10.1016\/j.lfs.2021.119204","volume":"272","author":"Y Zhang","year":"2021","unstructured":"Zhang, Y., Cao, X., Li, P., Fan, Y., Zhang, L., Ma, X., et al. (2021). microRNA-935-modified bone marrow mesenchymal stem cells-derived exosomes enhance osteoblast proliferation and differentiation in osteoporotic rats. Life Sciences, 272, 119204. https:\/\/doi.org\/10.1016\/j.lfs.2021.119204","journal-title":"Life Sciences"},{"issue":"3","key":"11080_CR176","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1007\/s13577-023-00881-y","volume":"36","author":"W Li","year":"2023","unstructured":"Li, W., Li, L., Cui, R., Chen, X., Hu, H., & Qiu, Y. (2023). Bone marrow mesenchymal stem cells derived Exosomal Lnc TUG1 promotes bone fracture recovery via miR-22-5p\/Anxa8 axis. Human Cell, 36(3), 1041\u20131053. https:\/\/doi.org\/10.1007\/s13577-023-00881-y","journal-title":"Human Cell"},{"issue":"6","key":"11080_CR177","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.jbiosc.2021.02.007","volume":"131","author":"L Zhang","year":"2021","unstructured":"Zhang, L., Wang, Q., Su, H., & Cheng, J. (2021). Exosomes from adipose derived mesenchymal stem cells alleviate diabetic osteoporosis in rats through suppressing NLRP3 inflammasome activation in osteoclasts. Journal of Bioscience and Bioengineering, 131(6), 671\u2013678. https:\/\/doi.org\/10.1016\/j.jbiosc.2021.02.007","journal-title":"Journal of Bioscience and Bioengineering"},{"issue":"1","key":"11080_CR178","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s13287-018-1121-9","volume":"10","author":"R Zuo","year":"2019","unstructured":"Zuo, R., Liu, M., Wang, Y., Li, J., Wang, W., Wu, J., et al. (2019). BM-MSC-derived exosomes alleviate radiation-induced bone loss by restoring the function of recipient BM-MSCs and activating Wnt\/beta-catenin signaling. Stem Cell Research & Therapy, 10(1), 30. https:\/\/doi.org\/10.1186\/s13287-018-1121-9","journal-title":"Stem Cell Research & Therapy"},{"key":"11080_CR179","doi-asserted-by":"publisher","unstructured":"Zhao, P., Xiao, L., Peng, J., Qian, Y. Q., & Huang, C. C. (2018). Exosomes derived from bone marrow mesenchymal stem cells improve osteoporosis through promoting osteoblast proliferation via MAPK pathway. European Review for Medical & Pharmacological Sciences, 22(12). https:\/\/doi.org\/10.26355\/eurrev_201806_15280","DOI":"10.26355\/eurrev_201806_15280"},{"issue":"1","key":"11080_CR180","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13018-020-02160-0","volume":"16","author":"L Li","year":"2021","unstructured":"Li, L., Zhou, X., Zhang, J., Liu, A., Zhang, C., Han, J., et al. (2021). Exosomal miR-186 derived from BMSCs promote osteogenesis through Hippo signaling pathway in postmenopausal osteoporosis. Journal of Orthopaedic Surgery and Research, 16(1), 23. https:\/\/doi.org\/10.1186\/s13018-020-02160-0","journal-title":"Journal of Orthopaedic Surgery and Research"},{"issue":"16","key":"11080_CR181","doi-asserted-by":"publisher","first-page":"e2205813","DOI":"10.1002\/smll.202205813","volume":"19","author":"Y Zhu","year":"2023","unstructured":"Zhu, Y., Yang, K., Cheng, Y., Liu, Y., Gu, R., Liu, X., et al. (2023). Apoptotic vesicles regulate bone metabolism via the miR1324\/SNX14\/SMAD1\/5 signaling axis. Small (Weinheim an Der Bergstrasse, Germany), 19(16), e2205813. https:\/\/doi.org\/10.1002\/smll.202205813","journal-title":"Small (Weinheim an Der Bergstrasse, Germany)"},{"issue":"3","key":"11080_CR182","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.mad.2007.12.002","volume":"129","author":"A Stolzing","year":"2008","unstructured":"Stolzing, A., Jones, E., McGonagle, D., & Scutt, A. (2008). Age-related changes in human bone marrow-derived mesenchymal stem cells: Consequences for cell therapies. Mechanisms of Ageing and Development, 129(3), 163\u2013173. https:\/\/doi.org\/10.1016\/j.mad.2007.12.002","journal-title":"Mechanisms of Ageing and Development"},{"key":"11080_CR183","doi-asserted-by":"publisher","first-page":"734810","DOI":"10.3389\/fbioe.2021.734810","volume":"9","author":"Z Ji","year":"2021","unstructured":"Ji, Z., Cai, Z., Gu, S., He, Y., Zhang, Z., Li, T., et al. (2021). Exosomes derived from human Adipose-Derived stem cells inhibit lipogenesis involving Hedgehog signaling pathway. Frontiers in Bioengineering and Biotechnology, 9, 734810. https:\/\/doi.org\/10.3389\/fbioe.2021.734810","journal-title":"Frontiers in Bioengineering and Biotechnology"},{"issue":"12","key":"11080_CR184","doi-asserted-by":"publisher","first-page":"e12152","DOI":"10.1002\/jev2.12152","volume":"10","author":"KS Lee","year":"2021","unstructured":"Lee, K. S., Lee, J., Kim, H. K., Yeom, S. H., Woo, C. H., Jung, Y. J., et al. (2021). Extracellular vesicles from adipose tissue-derived stem cells alleviate osteoporosis through osteoprotegerin and miR\u201021\u20105p. Journal of Extracellular Vesicles, 10(12), e12152. https:\/\/doi.org\/10.1002\/jev2.12152","journal-title":"Journal of Extracellular Vesicles"},{"issue":"1","key":"11080_CR185","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.bbrc.2018.11.109","volume":"508","author":"L Ren","year":"2019","unstructured":"Ren, L., Song, Z. J., Cai, Q. W., Chen, R. X., Zou, Y., Fu, Q., et al. (2019). Adipose mesenchymal stem cell-derived exosomes ameliorate hypoxia\/serum deprivation-induced osteocyte apoptosis and osteocyte-mediated osteoclastogenesis in vitro. Biochemical and Biophysical Research Communications, 508(1), 138\u2013144. https:\/\/doi.org\/10.1016\/j.bbrc.2018.11.109","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"1","key":"11080_CR186","doi-asserted-by":"publisher","first-page":"3602962","DOI":"10.1155\/2023\/3602962","volume":"2023","author":"XW Yao","year":"2023","unstructured":"Yao, X. W., Liu, Z. Y., Ma, N. F., Jiang, W. K., Zhou, Z., Chen, B., et al. (2023). Exosomes from Adipose-Derived stem cells alleviate Dexamethasone-Induced bone loss by regulating the Nrf2\/HO-1 axis. Oxid Med Cell Longev, 2023(1), 3602962. https:\/\/doi.org\/10.1155\/2023\/3602962","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"11080_CR187","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.bbrc.2020.02.001","volume":"524","author":"BC Yang","year":"2020","unstructured":"Yang, B. C., Kuang, M. J., Kang, J. Y., Zhao, J., Ma, J. X., & Ma, X. L. (2020). Human umbilical cord mesenchymal stem cell-derived exosomes act via the miR-1263\/Mob1\/Hippo signaling pathway to prevent apoptosis in disuse osteoporosis. Biochemical and Biophysical Research Communications, 524(4), 883\u2013889. https:\/\/doi.org\/10.1016\/j.bbrc.2020.02.001","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"11080_CR188","doi-asserted-by":"publisher","unstructured":"Zhao, Z. M., Ding, J. M., Li, Y., Wang, D. C., & Kuang, M. J. (2025). Human umbilical cord mesenchymal stem cell-derived exosomes promote osteogenesis in glucocorticoid-induced osteoporosis through PI3K\/AKT signaling pathway-mediated ferroptosis Inhibition. Stem Cells Transl Med, 14(3). https:\/\/doi.org\/10.1093\/stcltm\/szae096","DOI":"10.1093\/stcltm\/szae096"},{"issue":"5","key":"11080_CR189","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.7150\/thno.39238","volume":"10","author":"Y Hu","year":"2020","unstructured":"Hu, Y., Zhang, Y., Ni, C. Y., Chen, C. Y., Rao, S. S., Yin, H., et al. (2020). Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. Theranostics, 10(5), 2293\u20132308. https:\/\/doi.org\/10.7150\/thno.39238","journal-title":"Theranostics"},{"key":"11080_CR190","doi-asserted-by":"publisher","first-page":"963689721105746","DOI":"10.1177\/09636897211057465","volume":"30","author":"G Yahao","year":"2021","unstructured":"Yahao, G., & Xinjia, W. (2021). The role and mechanism of exosomes from umbilical cord mesenchymal stem cells in inducing osteogenesis and preventing osteoporosis. Cell Transplantation, 30, 9636897211057465. https:\/\/doi.org\/10.1177\/09636897211057465","journal-title":"Cell Transplantation"},{"issue":"5","key":"11080_CR191","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s43657-024-00177-7","volume":"4","author":"P Wu","year":"2024","unstructured":"Wu, P. (2024). Unveiling metabolic signatures in osteoarthritis progression through Non-Targeted metabolomics analysis: A paradigm shift in diagnosis and treatment prospects. Phenomics, 4(5), 525\u2013526. https:\/\/doi.org\/10.1007\/s43657-024-00177-7","journal-title":"Phenomics"},{"issue":"6","key":"11080_CR192","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1515\/jbcpp-2023-0200","volume":"34","author":"S Palermi","year":"2023","unstructured":"Palermi, S., Gnasso, R., Belviso, I., Iommazzo, I., Vecchiato, M., Marchini, A., et al. (2023). Stem cell therapy in sports medicine: Current applications, challenges and future perspectives. Journal of Basic and Clinical Physiology and Pharmacology, 34(6), 699\u2013706. https:\/\/doi.org\/10.1515\/jbcpp-2023-0200","journal-title":"Journal of Basic and Clinical Physiology and Pharmacology"},{"issue":"10","key":"11080_CR193","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/cells7100167","volume":"7","author":"M Nawaz","year":"2018","unstructured":"Nawaz, M., Shah, N., Zanetti, B. R., Maugeri, M., Silvestre, R. N., Fatima, F., et al. (2018). Extracellular vesicles and matrix remodeling enzymes: The emerging roles in extracellular matrix remodeling, progression of diseases and tissue repair. Cells, 7(10), 167. https:\/\/doi.org\/10.3390\/cells7100167","journal-title":"Cells"},{"issue":"1","key":"11080_CR194","doi-asserted-by":"publisher","first-page":"8157","DOI":"10.1080\/21655979.2021.1977562","volume":"12","author":"H Nie","year":"2021","unstructured":"Nie, H., & Jiang, Z. (2021). Bone mesenchymal stem cell-derived extracellular vesicles deliver microRNA-23b to alleviate spinal cord injury by targeting toll-like receptor TLR4 and inhibiting NF-kappaB pathway activation. Bioengineered, 12(1), 8157\u20138172. https:\/\/doi.org\/10.1080\/21655979.2021.1977562","journal-title":"Bioengineered"},{"issue":"1","key":"11080_CR195","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/s13287-020-01781-w","volume":"11","author":"L He","year":"2020","unstructured":"He, L., He, T., Xing, J., Zhou, Q., Fan, L., Liu, C., et al. (2020). Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis. Stem Cell Research & Therapy, 11(1), 276. https:\/\/doi.org\/10.1186\/s13287-020-01781-w","journal-title":"Stem Cell Research & Therapy"},{"key":"11080_CR196","doi-asserted-by":"publisher","first-page":"656153","DOI":"10.3389\/fcell.2021.656153","volume":"9","author":"Y Wang","year":"2021","unstructured":"Wang, Y., Zhao, M., Li, W., Yang, Y., Zhang, Z., Ma, R., et al. (2021). BMSC-Derived small extracellular vesicles induce cartilage reconstruction of temporomandibular joint osteoarthritis via Autotaxin-YAP signaling axis. Front Cell Dev Biol, 9, 656153. https:\/\/doi.org\/10.3389\/fcell.2021.656153","journal-title":"Front Cell Dev Biol"},{"key":"11080_CR197","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.biomaterials.2017.11.028","volume":"156","author":"S Zhang","year":"2018","unstructured":"Zhang, S., Chuah, S. J., Lai, R. C., Hui, J. H. P., Lim, S. K., & Toh, W. S. (2018). MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity. Biomaterials, 156, 16\u201327. https:\/\/doi.org\/10.1016\/j.biomaterials.2017.11.028","journal-title":"Biomaterials"},{"issue":"1","key":"11080_CR198","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1186\/s13075-020-02325-6","volume":"22","author":"X Chen","year":"2020","unstructured":"Chen, X., Shi, Y., Xue, P., Ma, X., Li, J., & Zhang, J. (2020). Mesenchymal stem cell-derived Exosomal microRNA-136-5p inhibits chondrocyte degeneration in traumatic osteoarthritis by targeting ELF3. Arthritis Res Ther, 22(1), 256. https:\/\/doi.org\/10.1186\/s13075-020-02325-6","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"11080_CR199","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00441-020-03193-x","volume":"381","author":"Z Jin","year":"2020","unstructured":"Jin, Z., Ren, J., & Qi, S. (2020). Exosomal miR-9-5p secreted by bone marrow-derived mesenchymal stem cells alleviates osteoarthritis by inhibiting syndecan-1. Cell and Tissue Research, 381(1), 99\u2013114. https:\/\/doi.org\/10.1007\/s00441-020-03193-x","journal-title":"Cell and Tissue Research"},{"issue":"10","key":"11080_CR200","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1302\/2046-3758.1010.BJR-2020-0540.R1","volume":"10","author":"A Sanghani-Kerai","year":"2021","unstructured":"Sanghani-Kerai, A., Black, C., Cheng, S. O., Collins, L., Schneider, N., Blunn, G., et al. (2021). Clinical outcomes following intra-articular injection of autologous adipose-derived mesenchymal stem cells for the treatment of osteoarthritis in dogs characterized by weight-bearing asymmetry. Bone Joint Res, 10(10), 650\u2013658. https:\/\/doi.org\/10.1302\/2046-3758.1010.BJR-2020-0540.R1","journal-title":"Bone Joint Res"},{"issue":"3","key":"11080_CR201","doi-asserted-by":"publisher","first-page":"295","DOI":"10.2217\/rme-2017-0152","volume":"13","author":"Y Song","year":"2018","unstructured":"Song, Y., Du, H., Dai, C., Zhang, L., Li, S., Hunter, D. J., et al. (2018). Human adipose-derived mesenchymal stem cells for osteoarthritis: A pilot study with long-term follow-up and repeated injections. Regenerative Medicine, 13(3), 295\u2013307. https:\/\/doi.org\/10.2217\/rme-2017-0152","journal-title":"Regenerative Medicine"},{"issue":"1","key":"11080_CR202","doi-asserted-by":"publisher","first-page":"1735249","DOI":"10.1080\/20013078.2020.1735249","volume":"9","author":"CH Woo","year":"2020","unstructured":"Woo, C. H., Kim, H. K., Jung, G. Y., Jung, Y. J., Lee, K. S., Yun, Y. E., et al. (2020). Small extracellular vesicles from human adipose-derived stem cells attenuate cartilage degeneration. J Extracell Vesicles, 9(1), 1735249. https:\/\/doi.org\/10.1080\/20013078.2020.1735249","journal-title":"J Extracell Vesicles"},{"issue":"1","key":"11080_CR203","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1038\/s41598-020-80032-7","volume":"11","author":"C Cavallo","year":"2021","unstructured":"Cavallo, C., Merli, G., Borz\u00ec, R. M., Zini, N., D\u2019Adamo, S., Guescini, M., et al. (2021). Small extracellular vesicles from adipose derived stromal cells significantly attenuate in vitro the NF-\u03baB dependent inflammatory\/catabolic environment of osteoarthritis. Scientific Reports, 11(1), 1053. https:\/\/doi.org\/10.1038\/s41598-020-80032-7","journal-title":"Scientific Reports"},{"issue":"5","key":"11080_CR204","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s12015-019-09899-y","volume":"15","author":"E Ragni","year":"2019","unstructured":"Ragni, E., Perucca Orfei, C., De Luca, P., Vigano, M., Colombini, A., Lugano, G., et al. (2019). miR-22-5p and miR-29a-5p are reliable reference genes for analyzing extracellular Vesicle-Associated MiRNAs in Adipose-Derived mesenchymal stem cells and are stable under inflammatory priming mimicking osteoarthritis condition. Stem Cell Rev Rep, 15(5), 743\u2013754. https:\/\/doi.org\/10.1007\/s12015-019-09899-y","journal-title":"Stem Cell Rev Rep"},{"issue":"1","key":"11080_CR205","doi-asserted-by":"publisher","first-page":"14148","DOI":"10.1038\/s41598-022-18476-2","volume":"12","author":"T Kitahashi","year":"2022","unstructured":"Kitahashi, T., Kogawa, R., Nakamura, K., & Sekiya, I. (2022). Integrin beta1, PDGFRbeta, and type II collagen are essential for meniscus regeneration by synovial mesenchymal stem cells in rats. Scientific Reports, 12(1), 14148. https:\/\/doi.org\/10.1038\/s41598-022-18476-2","journal-title":"Scientific Reports"},{"issue":"2","key":"11080_CR206","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1007\/s10787-023-01142-y","volume":"31","author":"R Kong","year":"2023","unstructured":"Kong, R., Zhang, J., Ji, L., Yu, Y., Gao, J., & Zhao, D. (2023). Synovial mesenchymal stem cell-derived Exosomal microRNA-320c facilitates cartilage damage repair by targeting ADAM19-dependent Wnt signalling in osteoarthritis rats. Inflammopharmacology, 31(2), 915\u2013926. https:\/\/doi.org\/10.1007\/s10787-023-01142-y","journal-title":"Inflammopharmacology"},{"issue":"3\u20134","key":"11080_CR207","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1007\/s10495-022-01787-0","volume":"28","author":"F Li","year":"2023","unstructured":"Li, F., Xu, Z., Xie, Z., Sun, X., Li, C., Chen, Y., et al. (2023). Adipose mesenchymal stem cells-derived exosomes alleviate osteoarthritis by transporting MicroRNA \u2013\u2009376c-3p and targeting the WNT-beta-catenin signaling axis. Apoptosis, 28(3\u20134), 362\u2013378. https:\/\/doi.org\/10.1007\/s10495-022-01787-0","journal-title":"Apoptosis"},{"issue":"1","key":"11080_CR208","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1186\/s13287-021-02507-2","volume":"12","author":"A Duan","year":"2021","unstructured":"Duan, A., Shen, K., Li, B., Li, C., Zhou, H., Kong, R., et al. (2021). Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model. Stem Cell Research & Therapy, 12(1), 427. https:\/\/doi.org\/10.1186\/s13287-021-02507-2","journal-title":"Stem Cell Research & Therapy"},{"key":"11080_CR209","doi-asserted-by":"publisher","first-page":"118987","DOI":"10.1016\/j.lfs.2020.118987","volume":"269","author":"M Qiu","year":"2021","unstructured":"Qiu, M., Liu, D., & Fu, Q. (2021). MiR-129-5p shuttled by human synovial mesenchymal stem cell-derived exosomes relieves IL-1beta induced osteoarthritis via targeting HMGB1. Life Sciences, 269, 118987. https:\/\/doi.org\/10.1016\/j.lfs.2020.118987","journal-title":"Life Sciences"},{"key":"11080_CR210","doi-asserted-by":"publisher","first-page":"102094","DOI":"10.1016\/j.arr.2023.102094","volume":"92","author":"S Zhu","year":"2023","unstructured":"Zhu, S., Wang, J., Suo, M., Huang, H., Liu, X., Wang, J., et al. (2023). Can extracellular vesicles be considered as a potential frontier in the treatment of intervertebral disc disease? Ageing Research Reviews, 92, 102094. https:\/\/doi.org\/10.1016\/j.arr.2023.102094","journal-title":"Ageing Research Reviews"},{"issue":"1","key":"11080_CR211","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s13287-022-02745-y","volume":"13","author":"W Zhang","year":"2022","unstructured":"Zhang, W., Sun, T., Li, Y., Yang, M., Zhao, Y., Liu, J., et al. (2022). Application of stem cells in the repair of intervertebral disc degeneration. Stem Cell Research & Therapy, 13(1), 70. https:\/\/doi.org\/10.1186\/s13287-022-02745-y","journal-title":"Stem Cell Research & Therapy"},{"issue":"7","key":"11080_CR212","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1007\/s12015-023-10570-w","volume":"19","author":"G Xu","year":"2023","unstructured":"Xu, G., Lu, X., Liu, S., Zhang, Y., Xu, S., Ma, X., et al. (2023). MSC-Derived exosomes ameliorate intervertebral disc degeneration by regulating the Keap1\/Nrf2 axis. Stem Cell Rev Rep, 19(7), 2465\u20132480. https:\/\/doi.org\/10.1007\/s12015-023-10570-w","journal-title":"Stem Cell Rev Rep"},{"issue":"14","key":"11080_CR213","doi-asserted-by":"publisher","first-page":"4084","DOI":"10.7150\/thno.33638","volume":"9","author":"Z Liao","year":"2019","unstructured":"Liao, Z., Luo, R., Li, G., Song, Y., Zhan, S., Zhao, K., et al. (2019). Exosomes from mesenchymal stem cells modulate Endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo. Theranostics, 9(14), 4084\u20134100. https:\/\/doi.org\/10.7150\/thno.33638","journal-title":"Theranostics"},{"issue":"3","key":"11080_CR214","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1080\/15384101.2020.1863682","volume":"20","author":"T Wen","year":"2021","unstructured":"Wen, T., Wang, H., Li, Y., Lin, Y., Zhao, S., Liu, J., et al. (2021). Bone mesenchymal stem cell-derived extracellular vesicles promote the repair of intervertebral disc degeneration by transferring microRNA-199a. Cell Cycle, 20(3), 256\u2013270. https:\/\/doi.org\/10.1080\/15384101.2020.1863682","journal-title":"Cell Cycle"},{"issue":"1","key":"11080_CR215","doi-asserted-by":"publisher","first-page":"8983667","DOI":"10.1155\/2022\/8983667","volume":"2022","author":"XJ Yu","year":"2022","unstructured":"Yu, X. J., Liu, Q. K., Lu, R., Wang, S. X., Xu, H. R., Wang, Y. G., et al. (2022). Bone marrow mesenchymal stem Cell-Derived extracellular vesicles carrying circ_0050205 attenuate intervertebral disc degeneration. Oxid Med Cell Longev, 2022(1), 8983667. https:\/\/doi.org\/10.1155\/2022\/8983667","journal-title":"Oxid Med Cell Longev"},{"key":"11080_CR216","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jot.2023.02.004","volume":"39","author":"D Chen","year":"2023","unstructured":"Chen, D., Jiang, X., & Zou, H. (2023). hASCs-derived Exosomal miR-155-5p targeting TGFbetaR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration. J Orthop Translat, 39, 163\u2013176. https:\/\/doi.org\/10.1016\/j.jot.2023.02.004","journal-title":"J Orthop Translat"},{"issue":"13","key":"11080_CR217","doi-asserted-by":"publisher","first-page":"3247","DOI":"10.1177\/0363546519876323","volume":"47","author":"C Wang","year":"2019","unstructured":"Wang, C., Song, W., Chen, B., Liu, X., & He, Y. (2019). Exosomes isolated from Adipose-Derived stem cells: A new Cell-Free approach to prevent the muscle degeneration associated with torn rotator cuffs. American Journal of Sports Medicine, 47(13), 3247\u20133255. https:\/\/doi.org\/10.1177\/0363546519876323","journal-title":"American Journal of Sports Medicine"},{"issue":"6","key":"11080_CR218","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.3892\/etm.2021.10866","volume":"22","author":"Z Zhang","year":"2021","unstructured":"Zhang, Z., Zhang, L., Yang, J., Huang, J., Cai, J., Zhang, S., et al. (2021). Influence of extracellular nanovesicles derived from adipose-derived stem cells on nucleus pulposus cell from patients with intervertebral disc degeneration. Exp Ther Med, 22(6), 1431. https:\/\/doi.org\/10.3892\/etm.2021.10866","journal-title":"Exp Ther Med"},{"issue":"1","key":"11080_CR219","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1186\/s12951-021-00991-5","volume":"19","author":"H Xing","year":"2021","unstructured":"Xing, H., Zhang, Z., Mao, Q., Wang, C., Zhou, Y., Zhou, X., et al. (2021). Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration. J Nanobiotechnology, 19(1), 264. https:\/\/doi.org\/10.1186\/s12951-021-00991-5","journal-title":"J Nanobiotechnology"},{"key":"11080_CR220","doi-asserted-by":"publisher","first-page":"1215698","DOI":"10.3389\/fcell.2023.1215698","volume":"11","author":"H Huang","year":"2023","unstructured":"Huang, H., Liu, X., Wang, J., Suo, M., Zhang, J., Sun, T., et al. (2023). Umbilical cord mesenchymal stem cells for regenerative treatment of intervertebral disc degeneration. Front Cell Dev Biol, 11, 1215698. https:\/\/doi.org\/10.3389\/fcell.2023.1215698","journal-title":"Front Cell Dev Biol"},{"issue":"3","key":"11080_CR221","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1177\/19476035231172154","volume":"15","author":"S Ekram","year":"2024","unstructured":"Ekram, S., Khalid, S., Ramzan, F., Salim, A., Bashir, I., Durrieu, M. C., et al. (2024). Mesenchymal stem Cell-Derived extracellular vesicles protect rat nucleus pulposus cells from oxidative stress. Cartilage, 15(3), 328\u2013344. https:\/\/doi.org\/10.1177\/19476035231172154","journal-title":"Cartilage"},{"issue":"8","key":"11080_CR222","doi-asserted-by":"publisher","first-page":"4839","DOI":"10.1021\/acsbiomaterials.3c01944","volume":"10","author":"XJ Yu","year":"2024","unstructured":"Yu, X. J., Bai, X. F., Qu, Y. K., Wang, S. X., Zhang, J., Yang, W., et al. (2024). Unveiling the therapeutic potential of hUCMSC-derived EVs in intervertebral disc degeneration through MALAT1\/miR-138-5p\/SLC7A11 coexpression regulation. ACS Biomaterials Science & Engineering, 10(8), 4839\u20134854. https:\/\/doi.org\/10.1021\/acsbiomaterials.3c01944","journal-title":"ACS Biomaterials Science & Engineering"},{"key":"11080_CR223","doi-asserted-by":"publisher","unstructured":"Yuan, Q., Wang, X., Liu, L., Cai, Y., Zhao, X., Ma, H., et al. (2020). Exosomes derived from human placental mesenchymal stromal cells carrying antagomiR-4450 alleviate intervertebral disc degeneration through upregulation of ZNF121. Stem Cells and Development, (0), 1038\u20131058. https:\/\/doi.org\/10.1089\/scd.2020.0083","DOI":"10.1089\/scd.2020.0083"},{"issue":"6","key":"11080_CR224","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1177\/2192568217747573","volume":"8","author":"KA Shaw","year":"2018","unstructured":"Shaw, K. A., Parada, S. A., Gloystein, D. M., & Devine, J. G. (2018). The science and clinical applications of placental tissues in spine surgery. Global Spine J, 8(6), 629\u2013637. https:\/\/doi.org\/10.1177\/2192568217747573","journal-title":"Global Spine J"}],"container-title":["Stem Cell Reviews and Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-026-11080-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12015-026-11080-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12015-026-11080-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T19:02:37Z","timestamp":1776798157000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12015-026-11080-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,7]]},"references-count":224,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["11080"],"URL":"https:\/\/doi.org\/10.1007\/s12015-026-11080-1","relation":{},"ISSN":["2629-3269","2629-3277"],"issn-type":[{"value":"2629-3269","type":"print"},{"value":"2629-3277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,7]]},"assertion":[{"value":"23 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Non applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Non applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Non applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"Non applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical Trial Number"}},{"value":"Artificial intelligence tools (ChatGPT5, OpenAI) were used solely to improve the English language, grammar, clarity, and readability of this manuscript. All scientific content, interpretations, and conclusions are entirely the authors\u2019 own work.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Generative AI"}}]}}