{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:17:26Z","timestamp":1791047846946,"version":"4.1.0"},"reference-count":210,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,7,31]],"date-time":"2009-07-31T00:00:00Z","timestamp":1248998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinic Rev Allerg Immunol"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1007\/s12016-009-8172-8","type":"journal-article","created":{"date-parts":[[2009,7,30]],"date-time":"2009-07-30T06:33:22Z","timestamp":1248935602000},"page":"62-77","source":"Crossref","is-referenced-by-count":41,"title":["Epigenetic Therapeutics in Autoimmune Disease"],"prefix":"10.1007","volume":"39","author":[{"given":"Moshe","family":"Szyf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,7,31]]},"reference":[{"key":"8172_CR1","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/art.10234","volume":"46","author":"Q Lu","year":"2002","unstructured":"Lu Q, Kaplan M, Ray D et al (2002) Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus. Arthritis Rheum 46:1282\u20131291","journal-title":"Arthritis Rheum"},{"key":"8172_CR2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1745-7254.2008.00739.x","volume":"29","author":"XB Mi","year":"2008","unstructured":"Mi XB, Zeng FQ (2008) Hypomethylation of interleukin-4 and -6 promoters in T cells from systemic lupus erythematosus patients. Acta Pharmacol Sin 29:105\u2013112","journal-title":"Acta Pharmacol Sin"},{"key":"8172_CR3","doi-asserted-by":"crossref","first-page":"7698","DOI":"10.4049\/jimmunol.0801643","volume":"182","author":"K Aoki","year":"2009","unstructured":"Aoki K, Sato N, Yamaguchi A, Kaminuma O, Hosozawa T, Miyatake S (2009) Regulation of DNA demethylation during maturation of CD4+ naive T cells by the conserved noncoding sequence 1. J Immunol 182:7698\u20137707","journal-title":"J Immunol"},{"key":"8172_CR4","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S1521-6616(03)00206-7","volume":"109","author":"B Richardson","year":"2003","unstructured":"Richardson B (2003) DNA methylation and autoimmune disease. Clin Immunol 109:72\u201379","journal-title":"Clin Immunol"},{"key":"8172_CR5","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1399-3038.2006.00465.x","volume":"17","author":"GP White","year":"2006","unstructured":"White GP, Hollams EM, Yerkovich ST et al (2006) CpG methylation patterns in the IFNgamma promoter in naive T cells: variations during Th1 and Th2 differentiation and between atopics and non-atopics. Pediatr Allergy Immunol 17:557\u2013564","journal-title":"Pediatr Allergy Immunol"},{"key":"8172_CR6","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1002\/jnr.21329","volume":"85","author":"FG Mastronardi","year":"2007","unstructured":"Mastronardi FG, Noor A, Wood DD, Paton T, Moscarello MA (2007) Peptidyl argininedeiminase 2 CpG island in multiple sclerosis white matter is hypomethylated. J Neurosci Res 85:2006\u20132016","journal-title":"J Neurosci Res"},{"key":"8172_CR7","first-page":"804","volume":"35","author":"N Hu","year":"2008","unstructured":"Hu N, Qiu X, Luo Y et al (2008) Abnormal histone modification patterns in lupus CD4+ T cells. J Rheumatol 35:804\u2013810","journal-title":"J Rheumatol"},{"key":"8172_CR8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev-pharmtox-061008-103102","volume":"49","author":"M Szyf","year":"2009","unstructured":"Szyf M (2009) Epigenetics, DNA methylation, and chromatin modifying drugs. Annu Rev Pharmacol Toxicol 49:243\u2013263","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"8172_CR9","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1593\/neo.07947","volume":"10","author":"B Ateeq","year":"2008","unstructured":"Ateeq B, Unterberger A, Szyf M, Rabbani SA (2008) Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo. Neoplasia 10:266\u2013278","journal-title":"Neoplasia"},{"key":"8172_CR10","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1093\/emboj\/17.17.4905","volume":"17","author":"A Razin","year":"1998","unstructured":"Razin A (1998) CpG methylation, chromatin structure and gene silencing\u2014a three-way connection. EMBO J 17:4905\u20134908","journal-title":"EMBO J"},{"key":"8172_CR11","first-page":"159","volume":"134","author":"M Groudine","year":"1983","unstructured":"Groudine M, Eisenman R, Gelinas R, Weintraub H (1983) Developmental aspects of chromatin structure and gene expression. Prog Clin Biol Res 134:159\u2013182","journal-title":"Prog Clin Biol Res"},{"key":"8172_CR12","first-page":"185","volume":"191","author":"PA Marks","year":"1985","unstructured":"Marks PA, Sheffery M, Rifkind RA (1985) Modulation of gene expression during terminal cell differentiation. Prog Clin Biol Res 191:185\u2013203","journal-title":"Prog Clin Biol Res"},{"key":"8172_CR13","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0092-8674(86)90286-2","volume":"45","author":"P Ramain","year":"1986","unstructured":"Ramain P, Bourouis M, Dretzen G, Richards G, Sobkowiak A, Bellard M (1986) Changes in the chromatin structure of Drosophila glue genes accompany developmental cessation of transcription in wild type and transformed strains. Cell 45:545\u2013553","journal-title":"Cell"},{"key":"8172_CR14","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/38664","volume":"389","author":"M Grunstein","year":"1997","unstructured":"Grunstein M (1997) Histone acetylation in chromatin structure and transcription. Nature 389:349\u2013352","journal-title":"Nature"},{"key":"8172_CR15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.gde.2006.02.006","volume":"16","author":"PD Varga-Weisz","year":"2006","unstructured":"Varga-Weisz PD, Becker PB (2006) Regulation of higher-order chromatin structures by nucleosome-remodelling factors. Curr Opin Genet Dev 16:151\u2013156","journal-title":"Curr Opin Genet Dev"},{"key":"8172_CR16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S1016-8478(23)13988-4","volume":"26","author":"SH Kwon","year":"2008","unstructured":"Kwon SH, Workman JL (2008) The heterochromatin protein 1 (HP1) family: put away a bias toward HP1. Mol Cell 26:217\u2013227","journal-title":"Mol Cell"},{"key":"8172_CR17","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0968-0004(03)00175-0","volume":"28","author":"A Bergmann","year":"2003","unstructured":"Bergmann A, Lane ME (2003) HIDden targets of microRNAs for growth control. Trends Biochem Sci 28:461\u2013463","journal-title":"Trends Biochem Sci"},{"key":"8172_CR18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2006.08.028","volume":"302","author":"B Zhang","year":"2007","unstructured":"Zhang B, Pan X, Cobb GP, Anderson TA (2007) MicroRNAs as oncogenes and tumor suppressors. Dev Biol 302:1\u201312","journal-title":"Dev Biol"},{"key":"8172_CR19","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cell.2008.12.027","volume":"136","author":"C Xiao","year":"2009","unstructured":"Xiao C, Rajewsky K (2009) MicroRNA control in the immune system: basic principles. Cell 136:26\u201336","journal-title":"Cell"},{"key":"8172_CR20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jaut.2009.02.012","volume":"32","author":"KM Pauley","year":"2009","unstructured":"Pauley KM, Cha S, Chan EK (2009) MicroRNA in autoimmunity and autoimmune diseases. J Autoimmun 32:189\u2013194","journal-title":"J Autoimmun"},{"key":"8172_CR21","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1084\/jem.20080707","volume":"205","author":"X Zhou","year":"2008","unstructured":"Zhou X, Jeker LT, Fife BT, Zhu S, Anderson MS, McManus MT, Bluestone JA (2008) Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med 205:1983\u20131991","journal-title":"J Exp Med"},{"key":"8172_CR22","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1126\/science.1130164","volume":"313","author":"NC Lau","year":"2006","unstructured":"Lau NC, Seto AG, Kim J et al (2006) Characterization of the piRNA complex from rat testes. Science 313:363\u2013367","journal-title":"Science"},{"key":"8172_CR23","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000090833","volume":"113","author":"TH Vu","year":"2006","unstructured":"Vu TH, Jirtle RL, Hoffman AR (2006) Cross-species clues of an epigenetic imprinting regulatory code for the IGF2R gene. Cytogenet Genome Res 113:202\u2013208","journal-title":"Cytogenet Genome Res"},{"key":"8172_CR24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0092-8674(00)80079-3","volume":"86","author":"JT Lee","year":"1996","unstructured":"Lee JT, Strauss WM, Dausman JA, Jaenisch R (1996) A 450\u00a0kb transgene displays properties of the mammalian X-inactivation center. Cell 86:83\u201394","journal-title":"Cell"},{"key":"8172_CR25","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1126\/science.1080372","volume":"299","author":"LP Lim","year":"2003","unstructured":"Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP (2003) Vertebrate microRNA genes. Science 299:1540","journal-title":"Science"},{"key":"8172_CR26","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281\u2013297","journal-title":"Cell"},{"key":"8172_CR27","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.4161\/cc.5.19.3340","volume":"5","author":"Y Saito","year":"2006","unstructured":"Saito Y, Jones PA (2006) Epigenetic activation of tumor suppressor microRNAs in human cancer cells. Cell Cycle 5:2220\u20132222","journal-title":"Cell Cycle"},{"key":"8172_CR28","doi-asserted-by":"crossref","first-page":"24R","DOI":"10.1203\/pdr.0b013e3180457684","volume":"61","author":"JC Chuang","year":"2007","unstructured":"Chuang JC, Jones PA (2007) Epigenetics and microRNAs. Pediatr Res 61:24R\u201329R","journal-title":"Pediatr Res"},{"key":"8172_CR29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1387\/ijdb.082691av","volume":"53","author":"A Verdel","year":"2009","unstructured":"Verdel A, Vavasseur A, Le Gorrec M, Touat-Todeschini L (2009) Common themes in siRNA-mediated epigenetic silencing pathways. Int J Dev Biol 53:245\u2013257","journal-title":"Int J Dev Biol"},{"key":"8172_CR30","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1093\/nar\/gkp127","volume":"37","author":"PG Hawkins","year":"2009","unstructured":"Hawkins PG, Santoso S, Adams C, Anest V, Morris KV (2009) Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells. Nucleic Acids Res 37:2984\u20132995","journal-title":"Nucleic Acids Res"},{"key":"8172_CR31","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jneuroim.2005.02.022","volume":"164","author":"S Camelo","year":"2005","unstructured":"Camelo S, Iglesias AH, Hwang D et al (2005) Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis. J Neuroimmunol 164:10\u201321","journal-title":"J Neuroimmunol"},{"key":"8172_CR32","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2174\/156802609788085250","volume":"9","author":"MA Halili","year":"2009","unstructured":"Halili MA, Andrews MR, Sweet MJ, Fairlie DP (2009) Histone deacetylase inhibitors in inflammatory disease. Curr Top Med Chem 9:309\u2013319","journal-title":"Curr Top Med Chem"},{"key":"8172_CR33","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/269029a0","volume":"269","author":"JT Finch","year":"1977","unstructured":"Finch JT, Lutter LC, Rhodes D et al (1977) Structure of nucleosome core particles of chromatin. Nature 269:29\u201336","journal-title":"Nature"},{"key":"8172_CR34","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrm1567","volume":"6","author":"K Sarma","year":"2005","unstructured":"Sarma K, Reinberg D (2005) Histone variants meet their match. Nat Rev Mol Cell Biol 6:139\u2013149","journal-title":"Nat Rev Mol Cell Biol"},{"key":"8172_CR35","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0962-8924(01)02001-3","volume":"11","author":"T Jenuwein","year":"2001","unstructured":"Jenuwein T (2001) Re-SET-ting heterochromatin by histone methyltransferases. Trends Cell Biol 11:266\u2013273","journal-title":"Trends Cell Biol"},{"key":"8172_CR36","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0968-0004(97)01016-5","volume":"22","author":"PA Wade","year":"1997","unstructured":"Wade PA, Pruss D, Wolffe AP (1997) Histone acetylation: chromatin in action. Trends Biochem Sci 22:128\u2013132","journal-title":"Trends Biochem Sci"},{"key":"8172_CR37","doi-asserted-by":"crossref","first-page":"13225","DOI":"10.1073\/pnas.1735528100","volume":"100","author":"Y Shiio","year":"2003","unstructured":"Shiio Y, Eisenman RN (2003) Histone sumoylation is associated with transcriptional repression. Proc Natl Acad Sci U S A 100:13225\u201313230","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8172_CR38","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev.biochem.75.103004.142422","volume":"2432","author":"A Shilatifard","year":"2006","unstructured":"Shilatifard A (2006) Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression. Annu Rev Biochem 2432:243\u2013269","journal-title":"Annu Rev Biochem"},{"key":"8172_CR39","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/ng.154","volume":"40","author":"Z Wang","year":"2008","unstructured":"Wang Z, Zang C, Rosenfeld JA (2008) Combinatorial patterns of histone acetylations and methylations in the human genome. Nat Genet 40:897\u2013903","journal-title":"Nat Genet"},{"key":"8172_CR40","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1101\/sqb.2004.69.235","volume":"69","author":"S Henikoff","year":"2004","unstructured":"Henikoff S, McKittrick E, Ahmad K (2004) Epigenetics, histone H3 variants, and the inheritance of chromatin states. Cold Spring Harb Symp Quant Biol 69:235\u2013243","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"8172_CR41","first-page":"91","volume":"41","author":"T Kusch","year":"2007","unstructured":"Kusch T, Workman JL (2007) Histone variants and complexes involved in their exchange. Subcell Biochem 41:91\u2013109","journal-title":"Subcell Biochem"},{"key":"8172_CR42","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1126\/science.272.5260.371","volume":"272","author":"AP Wolffe","year":"1996","unstructured":"Wolffe AP (1996) Histone deacetylase: a regulator of transcription. Science 272:371\u2013372","journal-title":"Science"},{"key":"8172_CR43","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0092-8674(00)80712-6","volume":"97","author":"D Wotton","year":"1999","unstructured":"Wotton D, Lo RS, Lee S, Massague J (1999) A Smad transcriptional corepressor. Cell 97:29\u201339","journal-title":"Cell"},{"key":"8172_CR44","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/(SICI)1521-1878(199808)20:8<615::AID-BIES4>3.0.CO;2-H","volume":"20","author":"MH Kuo","year":"1998","unstructured":"Kuo MH, Allis CD (1998) Roles of histone acetyltransferases and deacetylases in gene regulation. Bioessays 20:615\u2013626","journal-title":"Bioessays"},{"key":"8172_CR45","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1101\/gad.1232504","volume":"18","author":"AH Lund","year":"2004","unstructured":"Lund AH, van Lohuizen M (2004) Epigenetics and cancer. Genes Dev 18:2315\u20132335","journal-title":"Genes Dev"},{"key":"8172_CR46","doi-asserted-by":"crossref","first-page":"7336","DOI":"10.1016\/S0021-9258(18)34382-5","volume":"257","author":"M Perry","year":"1982","unstructured":"Perry M, Chalkley R (1982) Histone acetylation increases the solubility of chromatin and occurs sequentially over most of the chromatin. A novel model for the biological role of histone acetylation. J Biol Chem 257:7336\u20137347","journal-title":"J Biol Chem"},{"key":"8172_CR47","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0092-8674(93)90051-Q","volume":"72","author":"DY Lee","year":"1993","unstructured":"Lee DY, Hayes JJ, Pruss D, Wolffe AP (1993) A positive role for histone acetylation in transcription factor access to nucleosomal DNA. Cell 72:73\u201384","journal-title":"Cell"},{"key":"8172_CR48","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s10577-005-1023-4","volume":"14","author":"I Sinha","year":"2006","unstructured":"Sinha I, Wiren M, Ekwall K (2006) Genome-wide patterns of histone modifications in fission yeast. Chromosome Res 14:95\u2013105","journal-title":"Chromosome Res"},{"key":"8172_CR49","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-1-59745-454-4_7","volume":"387","author":"TY Roh","year":"2007","unstructured":"Roh TY, Zhao K (2007) High-resolution, genome-wide mapping of chromatin modifications by GMAT. Methods Mol Biol 387:95\u2013108","journal-title":"Methods Mol Biol"},{"key":"8172_CR50","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-1-59745-454-4_7","volume":"387","author":"TY Roh","year":"2008","unstructured":"Roh TY, Zhao K (2008) High-resolution, genome-wide mapping of chromatin modifications by GMAT. Methods Mol Biol 387:95\u2013108","journal-title":"Methods Mol Biol"},{"key":"8172_CR51","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bbrc.2005.02.147","volume":"330","author":"ZP Lu","year":"2005","unstructured":"Lu ZP, Ju ZL, Shi GY, Zhang JW, Sun J (2005) Histone deacetylase inhibitor trichostatin A reduces anti-DNA autoantibody production and represses IgH gene transcription. Biochem Biophys Res Commun 330:204\u2013209","journal-title":"Biochem Biophys Res Commun"},{"key":"8172_CR52","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4161\/epi.1.2.2678","volume":"1","author":"SG Gray","year":"2006","unstructured":"Gray SG, Dangond F (2006) Rationale for the use of histone deacetylase inhibitors as a dual therapeutic modality in multiple sclerosis. Epigenetics 1:67\u201375","journal-title":"Epigenetics"},{"key":"8172_CR53","first-page":"348","volume":"6","author":"R Tao","year":"2007","unstructured":"Tao R, Hancock WW (2007) Regulating regulatory T cells to achieve transplant tolerance. Hepatobiliary Pancreat Dis Int 6:348\u2013357","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"8172_CR54","doi-asserted-by":"crossref","first-page":"4796","DOI":"10.1073\/pnas.0712051105","volume":"105","author":"N Li","year":"2008","unstructured":"Li N, Zhao D, Kirschbaum M et al (2008) HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen. Proc Natl Acad Sci U S A 105:4796\u20134801","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8172_CR55","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/08916930802406300","volume":"42","author":"Y Kuwatsuka","year":"2009","unstructured":"Kuwatsuka Y, Ogawa F, Iwata Y et al (2009) Decreased levels of autoantibody against histone deacetylase 3 in patients with systemic sclerosis. Autoimmunity 42:120\u2013125","journal-title":"Autoimmunity"},{"key":"8172_CR56","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1139\/o05-041","volume":"83","author":"L Verdone","year":"2005","unstructured":"Verdone L, Caserta M, Di Mauro E (2005) Role of histone acetylation in the control of gene expression. Biochem Cell Biol 83:344\u2013353","journal-title":"Biochem Cell Biol"},{"key":"8172_CR57","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/ng0996-33","volume":"14","author":"J Borrow","year":"1996","unstructured":"Borrow J, Stanton VP Jr, Andresen JM et al (1996) The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. Nat Genet 14:33\u201341","journal-title":"Nat Genet"},{"key":"8172_CR58","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.tcb.2009.03.001","volume":"19","author":"H Attikum van","year":"2009","unstructured":"van Attikum H, Gasser SM (2009) Crosstalk between histone modifications during the DNA damage response. Trends Cell Biol 19:207\u2013217","journal-title":"Trends Cell Biol"},{"key":"8172_CR59","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0092-8674(00)00051-9","volume":"102","author":"T Ikura","year":"2000","unstructured":"Ikura T, Ogryzko VV, Grigoriev M et al (2000) Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell 102:463\u2013473","journal-title":"Cell"},{"key":"8172_CR60","doi-asserted-by":"crossref","first-page":"13182","DOI":"10.1073\/pnas.0504211102","volume":"102","author":"Y Sun","year":"2005","unstructured":"Sun Y, Jiang X, Chen S, Fernandes N, Price BD (2005) A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc Natl Acad Sci U S A 102:13182\u201313187","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8172_CR61","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.molcel.2006.11.021","volume":"24","author":"Y Tang","year":"2006","unstructured":"Tang Y, Luo J, Zhang W, Gu W (2006) Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell 24:827\u2013839","journal-title":"Mol Cell"},{"key":"8172_CR62","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.bcp.2004.05.037","volume":"68","author":"M Fu","year":"2004","unstructured":"Fu M, Wang C, Zhang X, Pestell RG (2004) Acetylation of nuclear receptors in cellular growth and apoptosis. Biochem Pharmacol 68:1199\u20131208","journal-title":"Biochem Pharmacol"},{"key":"8172_CR63","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.4049\/jimmunol.140.7.2197","volume":"140","author":"E Cornacchia","year":"1988","unstructured":"Cornacchia E, Golbus J, Maybaum J, Strahler J, Hanash S, Richardson B (1988) Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. J Immunol 140:2197\u20132200","journal-title":"J Immunol"},{"key":"8172_CR64","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1177\/096120339400300611","volume":"3","author":"RL Yung","year":"1994","unstructured":"Yung RL, Richardson BC (1994) Role of T cell DNA methylation in lupus syndromes. Lupus 3:487\u2013491","journal-title":"Lupus"},{"key":"8172_CR65","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.4049\/jimmunol.154.6.3025","volume":"154","author":"RL Yung","year":"1995","unstructured":"Yung RL, Quddus J, Chrisp CE, Johnson KJ, Richardson BC (1995) Mechanism of drug-induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo. J Immunol 154:3025\u20133035","journal-title":"J Immunol"},{"key":"8172_CR66","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1517\/13543770902895727","volume":"19","author":"F Manzo","year":"2009","unstructured":"Manzo F, Tambaro FP, Mai A, Altucci L (2009) Histone acetyltransferase inhibitors and preclinical studies. Expert Opin Ther Pat 19:761\u2013774","journal-title":"Expert Opin Ther Pat"},{"key":"8172_CR67","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.bmcl.2008.12.097","volume":"19","author":"A Mai","year":"2009","unstructured":"Mai A, Rotili D, Tarantino D et al (2009) Identification of 4-hydroxyquinolines inhibitors of p300\/CBP histone acetyltransferases. Bioorg Med Chem Lett 19:1132\u20131135","journal-title":"Bioorg Med Chem Lett"},{"key":"8172_CR68","doi-asserted-by":"crossref","first-page":"19134","DOI":"10.1074\/jbc.M301580200","volume":"278","author":"K Balasubramanyam","year":"2003","unstructured":"Balasubramanyam K, Swaminathan V, Ranganathan A, Kundu TK (2003) Small molecule modulators of histone acetyltransferase p300. J Biol Chem 278:19134\u201319140","journal-title":"J Biol Chem"},{"key":"8172_CR69","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1002\/cmdc.200800096","volume":"3","author":"JA Souto","year":"2008","unstructured":"Souto JA, Conte M, Alvarez R et al (2008) Synthesis of benzamides related to anacardic acid and their histone acetyltransferase (HAT) inhibitory activities. ChemMedChem 3:1435\u20131442","journal-title":"ChemMedChem"},{"key":"8172_CR70","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1021\/jm800657z","volume":"52","author":"M Arif","year":"2009","unstructured":"Arif M, Pradhan SK, Thanuja GR et al (2009) Mechanism of p300 specific histone acetyltransferase inhibition by small molecules. J Med Chem 52:267\u2013277","journal-title":"J Med Chem"},{"key":"8172_CR71","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jep.2008.05.006","volume":"118","author":"YH Lee","year":"2008","unstructured":"Lee YH, Jung MG, Kang HB et al (2008) Effect of anti-histone acetyltransferase activity from Rosa rugosa Thunb. (Rosaceae) extracts on androgen receptor-mediated transcriptional regulation. J Ethnopharmacol 118:412\u2013417","journal-title":"J Ethnopharmacol"},{"key":"8172_CR72","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/jcb.21803","volume":"105","author":"JA Buczek-Thomas","year":"2008","unstructured":"Buczek-Thomas JA, Hsia E, Rich CB, Foster JA, Nugent MA (2008) Inhibition of histone acetyltransferase by glycosaminoglycans. J Cell Biochem 105:108\u2013120","journal-title":"J Cell Biochem"},{"key":"8172_CR73","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1016\/j.febslet.2006.06.092","volume":"580","author":"Y Sun","year":"2006","unstructured":"Sun Y, Jiang X, Chen S, Price BD (2006) Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation. FEBS Lett 580:4353\u20134356","journal-title":"FEBS Lett"},{"key":"8172_CR74","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.sbi.2005.10.006","volume":"15","author":"MA Holbert","year":"2005","unstructured":"Holbert MA, Marmorstein R (2005) Structure and activity of enzymes that remove histone modifications. Curr Opin Struct Biol 15:673\u2013680","journal-title":"Curr Opin Struct Biol"},{"key":"8172_CR75","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.bbrc.2003.09.043","volume":"310","author":"KB Glaser","year":"2003","unstructured":"Glaser KB, Li J, Staver MJ, Wei RQ, Albert DH, Davidsen SK (2003) Role of class I and class II histone deacetylases in carcinoma cells using siRNA. Biochem Biophys Res Commun 310:529\u2013536","journal-title":"Biochem Biophys Res Commun"},{"key":"8172_CR76","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1158\/0008-5472.CAN-07-0312","volume":"67","author":"S Zimmermann","year":"2007","unstructured":"Zimmermann S, Kiefer F, Prudenziati M (2007) Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice. Cancer Res 67:9047\u20139054","journal-title":"Cancer Res"},{"key":"8172_CR77","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1158\/1078-0432.CCR-07-0990","volume":"14","author":"W Weichert","year":"2008","unstructured":"Weichert W, Roske A, Niesporek S et al (2008) Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo. Clin Cancer Res 14:1669\u20131677","journal-title":"Clin Cancer Res"},{"key":"8172_CR78","first-page":"769","volume":"18","author":"M Nakagawa","year":"2007","unstructured":"Nakagawa M, Oda Y, Eguchi T et al (2007) Expression profile of class I histone deacetylases in human cancer tissues. Oncol Rep 18:769\u2013774","journal-title":"Oncol Rep"},{"key":"8172_CR79","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1161\/CIRCRESAHA.107.149377","volume":"101","author":"D Mottet","year":"2007","unstructured":"Mottet D, Bellahcene A, Pirotte S et al (2007) Histone deacetylase 7 silencing alters endothelial cell migration, a key step in angiogenesis. Circ Res 101:1237\u20131246","journal-title":"Circ Res"},{"key":"8172_CR80","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1358\/dnp.2007.20.4.1101162","volume":"20","author":"L Gan","year":"2007","unstructured":"Gan L (2007) Therapeutic potential of sirtuin-activating compounds in Alzheimer's disease. Drug News Perspect 20:233\u2013239","journal-title":"Drug News Perspect"},{"key":"8172_CR81","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1161\/01.RES.0000147557.75257.ff","volume":"95","author":"RR Alcendor","year":"2004","unstructured":"Alcendor RR, Kirshenbaum LA, Imai S, Vatner SF, Sadoshima J (2004) Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Circ Res 95:971\u2013980","journal-title":"Circ Res"},{"key":"8172_CR82","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nm1652","volume":"13","author":"R Tao","year":"2007","unstructured":"Tao R, de Zoeten EF, Ozkaynak E et al (2007) Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med 13:1299\u20131307","journal-title":"Nat Med"},{"key":"8172_CR83","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S1369-5274(00)00064-3","volume":"3","author":"MR Gartenberg","year":"2000","unstructured":"Gartenberg MR (2000) The Sir proteins of Saccharomyces cerevisiae: mediators of transcriptional silencing and much more. Curr Opin Microbiol 3:132\u2013137","journal-title":"Curr Opin Microbiol"},{"key":"8172_CR84","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/35038524","volume":"1","author":"J Alfred","year":"2000","unstructured":"Alfred J (2000) Counting the calories to immortality. Nat Rev Genet 1:88","journal-title":"Nat Rev Genet"},{"key":"8172_CR85","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1091\/mbc.10.10.3125","volume":"10","author":"S Kim","year":"1999","unstructured":"Kim S, Benguria A, Lai CY, Jazwinski SM (1999) Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae. Mol Biol Cell 10:3125\u20133136","journal-title":"Mol Biol Cell"},{"key":"8172_CR86","first-page":"27","volume":"93","author":"P Peixoto","year":"2006","unstructured":"Peixoto P, Lansiaux A (2006) Histone-deacetylases inhibitors: from TSA to SAHA. Bull Cancer 93:27\u201336","journal-title":"Bull Cancer"},{"key":"8172_CR87","doi-asserted-by":"crossref","first-page":"10014","DOI":"10.1073\/pnas.180316197","volume":"97","author":"VM Richon","year":"2000","unstructured":"Richon VM, Sandhoff TW, Rifkind RA, Marks PA (2000) Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc Natl Acad Sci U S A 97:10014\u201310019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8172_CR88","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2174\/138920007780655397","volume":"8","author":"V Santini","year":"2007","unstructured":"Santini V, Gozzini A, Ferrari G (2007) Histone deacetylase inhibitors: molecular and biological activity as a premise to clinical application. Curr Drug Metab 8:383\u2013393","journal-title":"Curr Drug Metab"},{"key":"8172_CR89","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1158\/1535-7163.MCT-07-2026","volume":"7","author":"M Fournel","year":"2008","unstructured":"Fournel M, Bonfils C, Hou Y et al (2008) MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo. Mol Cancer Ther 7:759\u2013768","journal-title":"Mol Cancer Ther"},{"key":"8172_CR90","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.1038\/sj.onc.1210620","volume":"26","author":"WS Xu","year":"2007","unstructured":"Xu WS, Parmigiani RB, Marks PA (2007) Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene 26:5541\u20135552","journal-title":"Oncogene"},{"key":"8172_CR91","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1358\/dot.2007.43.9.1112980","volume":"43","author":"M Duvic","year":"2007","unstructured":"Duvic M, Vu J (2007) Vorinostat in cutaneous T-cell lymphoma. Drugs Today (Barc) 43:585\u2013599","journal-title":"Drugs Today (Barc)"},{"key":"8172_CR92","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1200\/JCO.2007.14.5730","volume":"26","author":"LL Siu","year":"2008","unstructured":"Siu LL, Pili R, Duran I et al (2008) Phase I study of MGCD0103 given as a three-times-per-week oral dose in patients with advanced solid tumors. J Clin Oncol 26:1940\u20131947","journal-title":"J Clin Oncol"},{"key":"8172_CR93","first-page":"485","volume":"8","author":"J Kell","year":"2007","unstructured":"Kell J (2007) Drug evaluation: MGCD-0103, a histone deacetylase inhibitor for the treatment of cancer. Curr Opin Investig Drugs 8:485\u2013492","journal-title":"Curr Opin Investig Drugs"},{"key":"8172_CR94","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1517\/13543784.16.5.659","volume":"16","author":"WK Rasheed","year":"2007","unstructured":"Rasheed WK, Johnstone RW, Prince HM (2007) Histone deacetylase inhibitors in cancer therapy. Expert Opin Investig Drugs 16:659\u2013678","journal-title":"Expert Opin Investig Drugs"},{"key":"8172_CR95","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/978-1-4020-6554-5_13","volume":"615","author":"S Shankar","year":"2008","unstructured":"Shankar S, Srivastava RK (2008) Histone deacetylase inhibitors: mechanisms and clinical significance in cancer: HDAC inhibitor-induced apoptosis. Adv Exp Med Biol 615:261\u2013298","journal-title":"Adv Exp Med Biol"},{"key":"8172_CR96","doi-asserted-by":"crossref","first-page":"34940","DOI":"10.1074\/jbc.274.49.34940","volume":"274","author":"LC Sambucetti","year":"1999","unstructured":"Sambucetti LC, Fischer DD, Zabludoff S et al (1999) Histone deacetylase inhibition selectively alters the activity and expression of cell cycle proteins leading to specific chromatin acetylation and antiproliferative effects. J Biol Chem 274:34940\u201334947","journal-title":"J Biol Chem"},{"key":"8172_CR97","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI16153","volume":"111","author":"N Mishra","year":"2003","unstructured":"Mishra N, Reilly CM, Brown DR, Ruiz P, Gilkeson GS (2003) Histone deacetylase inhibitors modulate renal disease in the MRL-lpr\/lpr mouse. J Clin Invest 111:539\u2013552","journal-title":"J Clin Invest"},{"key":"8172_CR98","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0092-8674(01)00196-9","volume":"104","author":"SB Seo","year":"2001","unstructured":"Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (2001) Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein. Cell 104:119\u2013130","journal-title":"Cell"},{"key":"8172_CR99","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1101\/gad.351205","volume":"19","author":"P Hublitz","year":"2005","unstructured":"Hublitz P, Kunowska N, Mayer UP et al (2005) NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. Genes Dev 19:2912\u20132924","journal-title":"Genes Dev"},{"key":"8172_CR100","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1038\/sj.onc.1210895","volume":"27","author":"JK Wiencke","year":"2008","unstructured":"Wiencke JK, Zheng S, Morrison Z, Yeh RF (2008) Differentially expressed genes are marked by histone 3 lysine 9 trimethylation in human cancer cells. Oncogene 27:2412\u20132421","journal-title":"Oncogene"},{"key":"8172_CR101","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1128\/MCB.25.11.4650-4661.2005","volume":"25","author":"F Miao","year":"2005","unstructured":"Miao F, Natarajan R (2005) Mapping global histone methylation patterns in the coding regions of human genes. Mol Cell Biol 25:4650\u20134661","journal-title":"Mol Cell Biol"},{"key":"8172_CR102","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nature01080","volume":"419","author":"H Santos-Rosa","year":"2002","unstructured":"Santos-Rosa H, Schneider R, Bannister AJ et al (2002) Active genes are tri-methylated at K4 of histone H3. Nature 419:407\u2013411","journal-title":"Nature"},{"key":"8172_CR103","doi-asserted-by":"crossref","first-page":"4479","DOI":"10.1371\/journal.pone.0004479","volume":"4","author":"P Akan","year":"2009","unstructured":"Akan P, Sahlen M, Deloukas P (2009) A histone map of human chromosome 20q13.12. PLoS ONE 4:4479","journal-title":"PLoS ONE"},{"key":"8172_CR104","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cell.2006.02.041","volume":"125","author":"BE Bernstein","year":"2006","unstructured":"Bernstein BE, Mikkelsen TS, Xie X et al (2006) A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125:315\u2013326","journal-title":"Cell"},{"key":"8172_CR105","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.stem.2007.08.004","volume":"1","author":"XD Zhao","year":"2007","unstructured":"Zhao XD, Han X, Chew JL et al (2007) Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. Cell Stem Cell 1:286\u2013298","journal-title":"Cell Stem Cell"},{"key":"8172_CR106","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/35020506","volume":"406","author":"S Rea","year":"2000","unstructured":"Rea S, Eisenhaber F, O'Carroll D et al (2000) Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 406:593\u2013599","journal-title":"Nature"},{"key":"8172_CR107","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ceb.2005.02.006","volume":"17","author":"AH Peters","year":"2005","unstructured":"Peters AH, Schubeler D (2005) Methylation of histones: playing memory with DNA. Curr Opin Cell Biol 17:230\u2013238","journal-title":"Curr Opin Cell Biol"},{"key":"8172_CR108","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.biophys.34.040204.144452","volume":"34","author":"X Cheng","year":"2005","unstructured":"Cheng X, Collins RE, Zhang X (2005) Structural and sequence motifs of protein (histone) methylation enzymes. Annu Rev Biophys Biomol Struct 34:267\u2013294","journal-title":"Annu Rev Biophys Biomol Struct"},{"key":"8172_CR109","first-page":"6456","volume":"62","author":"CT Nguyen","year":"2002","unstructured":"Nguyen CT, Weisenberger DJ, Velicescu M et al (2002) Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2\u2032-deoxycytidine. Cancer Res 62:6456\u20136461","journal-title":"Cancer Res"},{"key":"8172_CR110","doi-asserted-by":"crossref","first-page":"8902","DOI":"10.1038\/sj.onc.1207050","volume":"22","author":"MM Coombes","year":"2003","unstructured":"Coombes MM, Briggs KL, Bone JR, Clayman GL, El-Naggar AK, Dent SY (2003) Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation. Oncogene 22:8902\u20138911","journal-title":"Oncogene"},{"key":"8172_CR111","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.3748\/wjg.v13.i46.6166","volume":"13","author":"CF Meng","year":"2007","unstructured":"Meng CF, Zhu XJ, Peng G, Dai DQ (2007) Re-expression of methylation-induced tumor suppressor gene silencing is associated with the state of histone modification in gastric cancer cell lines. World J Gastroenterol 13:6166\u20136171","journal-title":"World J Gastroenterol"},{"key":"8172_CR112","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/ng1950","volume":"39","author":"Y Schlesinger","year":"2007","unstructured":"Schlesinger Y, Straussman R, Keshet I et al (2007) Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nat Genet 39:232\u2013236","journal-title":"Nat Genet"},{"key":"8172_CR113","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nchembio721","volume":"1","author":"D Greiner","year":"2005","unstructured":"Greiner D, Bonaldi T, Eskeland R, Roemer E, Imhof A (2005) Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nat Chem Biol 1:143\u2013145","journal-title":"Nat Chem Biol"},{"key":"8172_CR114","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.molcel.2007.01.017","volume":"25","author":"S Kubicek","year":"2007","unstructured":"Kubicek S, O'Sullivan RJ, August EM et al (2007) Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell 25:473\u2013481","journal-title":"Mol Cell"},{"key":"8172_CR115","doi-asserted-by":"crossref","first-page":"R62","DOI":"10.1186\/gb-2009-10-6-r62","volume":"10","author":"X Zhang","year":"2009","unstructured":"Zhang X, Bernatavichute YV, Cokus S, Pellegrini M, Jacobsen SE (2009) Genome-wide analysis of mono-, di- and trimethylation of histone H3 lysine 4 in Arabidopsis thaliana. Genome Biol 10:R62","journal-title":"Genome Biol"},{"key":"8172_CR116","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2004.12.012","volume":"119","author":"Y Shi","year":"2004","unstructured":"Shi Y, Lan F, Matson C et al (2004) Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119:941\u2013953","journal-title":"Cell"},{"key":"8172_CR117","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature04020","volume":"437","author":"E Metzger","year":"2005","unstructured":"Metzger E, Wissmann M, Yin N et al (2005) LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 437:436\u2013439","journal-title":"Nature"},{"key":"8172_CR118","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nature04853","volume":"442","author":"RJ Klose","year":"2006","unstructured":"Klose RJ, Yamane K, Bae Y et al (2006) The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Nature 442:312\u2013316","journal-title":"Nature"},{"key":"8172_CR119","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/nature04021","volume":"437","author":"MG Lee","year":"2005","unstructured":"Lee MG, Wynder C, Cooch N, Shiekhattar R (2005) An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature 437:432\u2013435","journal-title":"Nature"},{"key":"8172_CR120","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/nature05671","volume":"446","author":"J Wang","year":"2007","unstructured":"Wang J, Scully K, Zhu X et al (2007) Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 446:882\u2013887","journal-title":"Nature"},{"key":"8172_CR121","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nature04433","volume":"439","author":"Y Tsukada","year":"2006","unstructured":"Tsukada Y, Fang J, Erdjument-Bromage H et al (2006) Histone demethylation by a family of JmjC domain-containing proteins. Nature 439:811\u2013816","journal-title":"Nature"},{"key":"8172_CR122","doi-asserted-by":"crossref","first-page":"8023","DOI":"10.1073\/pnas.0700720104","volume":"104","author":"Y Huang","year":"2007","unstructured":"Huang Y, Greene E, Murray Stewart T et al (2007) Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes. Proc Natl Acad Sci U S A 104:8023\u20138028","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8172_CR123","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.chembiol.2006.05.004","volume":"13","author":"MG Lee","year":"2006","unstructured":"Lee MG, Wynder C, Schmidt DM, McCafferty DG, Shiekhattar R (2006) Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem Biol 13:563\u2013567","journal-title":"Chem Biol"},{"key":"8172_CR124","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S1074-7613(02)00314-X","volume":"16","author":"DU Lee","year":"2002","unstructured":"Lee DU, Agarwal S, Rao A (2002) Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity 16:649\u2013660","journal-title":"Immunity"},{"key":"8172_CR125","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.4049\/jimmunol.169.4.1893","volume":"169","author":"S Santangelo","year":"2002","unstructured":"Santangelo S, Cousins DJ, Winkelmann NE, Staynov DZ (2002) DNA methylation changes at human Th2 cytokine genes coincide with DNase I hypersensitive site formation during CD4(+) T cell differentiation. J Immunol 169:1893\u20131903","journal-title":"J Immunol"},{"key":"8172_CR126","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/ncprheum0573","volume":"3","author":"B Richardson","year":"2007","unstructured":"Richardson B (2007) Primer: epigenetics of autoimmunity. Nat Clin Pract Rheumatol 3:521\u2013527","journal-title":"Nat Clin Pract Rheumatol"},{"key":"8172_CR127","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1196\/annals.1422.015","volume":"1108","author":"E Balada","year":"2007","unstructured":"Balada E, Ordi-Ros J, Vilardell-Tarres M (2007) DNA methylation and systemic lupus erythematosus. Ann N Y Acad Sci 1108:127\u2013136","journal-title":"Ann N Y Acad Sci"},{"key":"8172_CR128","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1172\/JCI116576","volume":"92","author":"J Quddus","year":"1993","unstructured":"Quddus J, Johnson KJ, Gavalchin J et al (1993) Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice. J Clin Invest 92:38\u201353","journal-title":"J Clin Invest"},{"key":"8172_CR129","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1002\/eji.1830200917","volume":"20","author":"H Yoshida","year":"1990","unstructured":"Yoshida H, Yoshida M, Merino R, Shibata T, Izui S (1990) 5-Azacytidine inhibits the lpr gene-induced lymphadenopathy and acceleration of lupus-like syndrome in MRL\/MpJ-lpr\/lpr mice. Eur J Immunol 20:1989\u20131993","journal-title":"Eur J Immunol"},{"key":"8172_CR130","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1073\/pnas.74.7.2725","volume":"74","author":"A Razin","year":"1977","unstructured":"Razin A, Cedar H (1977) Distribution of 5-methylcytosine in chromatin. Proc Natl Acad Sci U S A 74:2725\u20132728","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8172_CR131","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/890","volume":"19","author":"M Okano","year":"1998","unstructured":"Okano M, Xie S, Li E (1998) Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases [letter]. Nat Genet 19:219\u2013220","journal-title":"Nat Genet"},{"key":"8172_CR132","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1159\/000015083","volume":"82","author":"A Vilain","year":"1998","unstructured":"Vilain A, Apiou F, Dutrillaux B, Malfoy B (1998) Assignment of candidate DNA methyltransferase gene (DNMT2) to human chromosome band 10p15.1 by in situ hybridization. Cytogenet Cell Genet 82:120","journal-title":"Cytogenet Cell Genet"},{"key":"8172_CR133","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1101\/gad.1472907","volume":"21","author":"K Rai","year":"2007","unstructured":"Rai K, Chidester S, Zavala CV et al (2007) Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish. Genes Dev 21:261\u2013266","journal-title":"Genes Dev"},{"key":"8172_CR134","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1126\/science.1120976","volume":"311","author":"MG Goll","year":"2006","unstructured":"Goll MG, Kirpekar F, Maggert KA et al (2006) Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. Science 311:395\u2013398","journal-title":"Science"},{"key":"8172_CR135","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1126\/science.1065848","volume":"294","author":"D Bourc'his","year":"2001","unstructured":"Bourc'his D, Xu GL, Lin CS, Bollman B, Bestor TH (2001) Dnmt3L and the establishment of maternal genomic imprints. Science 294:2536\u20132539","journal-title":"Science"},{"key":"8172_CR136","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1126\/science.6254144","volume":"210","author":"A Razin","year":"1980","unstructured":"Razin A, Riggs AD (1980) DNA methylation and gene function. Science 210:604\u2013610","journal-title":"Science"},{"key":"8172_CR137","first-page":"119","volume":"198","author":"JC Wu","year":"1985","unstructured":"Wu JC, Santi DV (1985) On the mechanism and inhibition of DNA cytosine methyltransferases. Prog Clin Biol Res 198:119\u2013129","journal-title":"Prog Clin Biol Res"},{"key":"8172_CR138","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.1073\/pnas.96.11.6107","volume":"96","author":"S Ramchandani","year":"1999","unstructured":"Ramchandani S, Bhattacharya SK, Cervoni N, Szyf M (1999) DNA methylation is a reversible biological signal. Proc Natl Acad Sci U S A 96:6107\u20136112","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8172_CR139","doi-asserted-by":"crossref","first-page":"15763","DOI":"10.1074\/jbc.M511767200","volume":"281","author":"JM Levenson","year":"2006","unstructured":"Levenson JM, Roth TL, Lubin FD et al (2006) Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus. J Biol Chem 281:15763\u201315773","journal-title":"J Biol Chem"},{"key":"8172_CR140","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/ni887","volume":"4","author":"D Bruniquel","year":"2003","unstructured":"Bruniquel D, Schwartz RH (2003) Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process. Nat Immunol 4:235\u2013240","journal-title":"Nat Immunol"},{"key":"8172_CR141","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1126\/science.1147939","volume":"317","author":"M Bostick","year":"2007","unstructured":"Bostick M, Kim JK, Esteve PO, Clark A, Pradhan S, Jacobsen SE (2007) UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science 317:1760\u20131764","journal-title":"Science"},{"key":"8172_CR142","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/nature04431","volume":"439","author":"E Vire","year":"2006","unstructured":"Vire E, Brenner C, Deplus R et al (2006) The Polycomb group protein EZH2 directly controls DNA methylation. Nature 439:871\u2013874","journal-title":"Nature"},{"key":"8172_CR143","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1126\/science.1065173","volume":"295","author":"L Croce Di","year":"2002","unstructured":"Di Croce L, Raker VA, Corsaro M et al (2002) Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor. Science 295:1079\u20131082","journal-title":"Science"},{"key":"8172_CR144","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.4049\/jimmunol.176.7.4083","volume":"176","author":"EN Kersh","year":"2006","unstructured":"Kersh EN, Fitzpatrick DR, Murali-Krishna K et al (2006) Rapid demethylation of the IFN-{gamma} gene occurs in memory but not naive CD8 T cells. J Immunol 176:4083\u20134093","journal-title":"J Immunol"},{"key":"8172_CR145","doi-asserted-by":"crossref","first-page":"8581","DOI":"10.1016\/S0021-9258(18)34161-9","volume":"257","author":"RA Gjerset","year":"1982","unstructured":"Gjerset RA, Martin DW Jr (1982) Presence of a DNA demethylating activity in the nucleus of murine erythroleukemic cells. J Biol Chem 257:8581\u20138583","journal-title":"J Biol Chem"},{"key":"8172_CR146","doi-asserted-by":"crossref","first-page":"12690","DOI":"10.1074\/jbc.270.21.12690","volume":"270","author":"M Szyf","year":"1995","unstructured":"Szyf M, Theberge J, Bozovic V (1995) Ras induces a general DNA demethylation activity in mouse embryonal P19 cells. J Biol Chem 270:12690\u201312696","journal-title":"J Biol Chem"},{"key":"8172_CR147","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/mc.10033","volume":"33","author":"SK Patra","year":"2002","unstructured":"Patra SK, Patra A, Zhao H, Dahiya R (2002) DNA methyltransferase and demethylase in human prostate cancer. Mol Carcinog 33:163\u2013171","journal-title":"Mol Carcinog"},{"key":"8172_CR148","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.1073\/pnas.90.10.4684","volume":"90","author":"JP Jost","year":"1993","unstructured":"Jost JP (1993) Nuclear extracts of chicken embryos promote an active demethylation of DNA by excision repair of 5-methyldeoxycytidine. Proc Natl Acad Sci U S A 90:4684\u20134688","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8172_CR149","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1073\/pnas.100107597","volume":"97","author":"B Zhu","year":"2000","unstructured":"Zhu B, Zheng Y, Hess D et al (2000) 5-methylcytosine-DNA glycosylase activity is present in a cloned G\/T mismatch DNA glycosylase associated with the chicken embryo DNA demethylation complex. Proc Natl Acad Sci U S A 97:5135\u20135139","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8172_CR150","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nature05515","volume":"445","author":"G Barreto","year":"2007","unstructured":"Barreto G, Schafer A, Marhold J et al (2007) Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature 445:671\u2013675","journal-title":"Nature"},{"key":"8172_CR151","doi-asserted-by":"crossref","first-page":"e1000013","DOI":"10.1371\/journal.pgen.1000013","volume":"4","author":"SG Jin","year":"2008","unstructured":"Jin SG, Guo C, Pfeifer GP (2008) GADD45A does not promote DNA demethylation. PLoS Genet 4:e1000013","journal-title":"PLoS Genet"},{"key":"8172_CR152","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nature06544","volume":"452","author":"R Metivier","year":"2008","unstructured":"Metivier R, Gallais R, Tiffoche C et al (2008) Cyclical DNA methylation of a transcriptionally active promoter. Nature 452:45\u201350","journal-title":"Nature"},{"key":"8172_CR153","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature06640","volume":"452","author":"S Kangaspeska","year":"2008","unstructured":"Kangaspeska S, Stride B, Metivier R et al (2008) Transient cyclical methylation of promoter DNA. Nature 452:112\u2013115","journal-title":"Nature"},{"key":"8172_CR154","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.cell.2008.11.042","volume":"135","author":"K Rai","year":"2008","unstructured":"Rai K, Huggins IJ, James SR, Karpf AR, Jones DA, Cairns BR (2008) DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell 135:1201\u20131212","journal-title":"Cell"},{"key":"8172_CR155","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/17533","volume":"397","author":"SK Bhattacharya","year":"1999","unstructured":"Bhattacharya SK, Ramchandani S, Cervoni N, Szyf M (1999) A mammalian protein with specific demethylase activity for mCpG DNA [see comments]. Nature 397:579\u2013583","journal-title":"Nature"},{"key":"8172_CR156","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.bmcl.2007.12.027","volume":"18","author":"S Hamm","year":"2008","unstructured":"Hamm S, Just G, Lacoste N, Moitessier N, Szyf M, Mamer O (2008) On the mechanism of demethylation of 5-methylcytosine in DNA. Bioorg Med Chem Lett 18:1046\u20131049","journal-title":"Bioorg Med Chem Lett"},{"key":"8172_CR157","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1126\/science.1169786","volume":"324","author":"S Kriaucionis","year":"2009","unstructured":"Kriaucionis S, Heintz N (2009) The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 324:929\u2013930","journal-title":"Science"},{"key":"8172_CR158","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/12659","volume":"23","author":"HH Ng","year":"1999","unstructured":"Ng HH, Zhang Y, Hendrich B et al (1999) MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat Genet 23:58\u201361","journal-title":"Nat Genet"},{"key":"8172_CR159","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1101\/gad.194101","volume":"15","author":"B Hendrich","year":"2001","unstructured":"Hendrich B, Guy J, Ramsahoye B, Wilson VA, Bird A (2001) Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development. Genes Dev 15:710\u2013723","journal-title":"Genes Dev"},{"key":"8172_CR160","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/ng1155","volume":"34","author":"OJ Sansom","year":"2003","unstructured":"Sansom OJ, Berger J, Bishop SM, Hendrich B, Bird A, Clarke AR (2003) Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nat Genet 34:145\u2013147","journal-title":"Nat Genet"},{"key":"8172_CR161","doi-asserted-by":"crossref","first-page":"35791","DOI":"10.1074\/jbc.C200408200","volume":"277","author":"N Detich","year":"2002","unstructured":"Detich N, Theberge J, Szyf M (2002) Promoter-specific activation and demethylation by MBD2\/demethylase. J Biol Chem 277:35791\u201335794","journal-title":"J Biol Chem"},{"key":"8172_CR162","doi-asserted-by":"crossref","first-page":"27586","DOI":"10.1074\/jbc.M303740200","volume":"278","author":"N Detich","year":"2003","unstructured":"Detich N, Bovenzi V, Szyf M (2003) Valproate induces replication-independent active DNA demethylation. J Biol Chem 278:27586\u201327592","journal-title":"J Biol Chem"},{"key":"8172_CR163","doi-asserted-by":"crossref","first-page":"15333","DOI":"10.1074\/jbc.M300608200","volume":"278","author":"A Goel","year":"2003","unstructured":"Goel A, Mathupala SP, Pedersen PL (2003) Glucose metabolism in cancer. Evidence that demethylation events play a role in activating type ii hexokinase gene expression. J Biol Chem 278:15333\u201315340","journal-title":"J Biol Chem"},{"key":"8172_CR164","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/jgm.288","volume":"4","author":"A Slack","year":"2002","unstructured":"Slack A, Bovenzi V, Bigey P et al (2002) Antisense MBD2 gene therapy inhibits tumorigenesis. J Gene Med 4:381\u2013389","journal-title":"J Gene Med"},{"key":"8172_CR165","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/carcin\/bgh045","volume":"25","author":"PM Campbell","year":"2003","unstructured":"Campbell PM, Bovenzi V, Szyf M (2003) Methylated DNA binding protein 2 antisense inhibitors suppress tumorigenesis of human cancer lines in vitro and in vivo. Carcinogenesis 25:499\u2013507","journal-title":"Carcinogenesis"},{"key":"8172_CR166","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/carcin\/bgi009","volume":"26","author":"P Pakneshan","year":"2004","unstructured":"Pakneshan P, Szyf M, Rabbani SA (2004) Methylation and inhibition of uPA expression by RAS oncogene: divergence of growth control and invasion in breast cancer cells. Carcinogenesis 26:557\u2013564","journal-title":"Carcinogenesis"},{"key":"8172_CR167","doi-asserted-by":"crossref","first-page":"9202","DOI":"10.1158\/0008-5472.CAN-06-1954","volume":"66","author":"N Shukeir","year":"2006","unstructured":"Shukeir N, Pakneshan P, Chen G, Szyf M, Rabbani SA (2006) Alteration of the methylation status of tumor-promoting genes decreases prostate cancer cell invasiveness and tumorigenesis in vitro and in vivo. Cancer Res 66:9202\u20139210","journal-title":"Cancer Res"},{"key":"8172_CR168","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1189\/jlb.0107064","volume":"81","author":"E Balada","year":"2007","unstructured":"Balada E, Ordi-Ros J, Serrano-Acedo S, Martinez-Lostao L, Vilardell-Tarres M (2007) Transcript overexpression of the MBD2 and MBD4 genes in CD4+ T cells from systemic lupus erythematosus patients. J Leukoc Biol 81:1609\u20131616","journal-title":"J Leukoc Biol"},{"key":"8172_CR169","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0165-6147(94)90317-4","volume":"15","author":"M Szyf","year":"1994","unstructured":"Szyf M (1994) DNA methylation properties: consequences for pharmacology. Trends Pharmacol Sci 15:233\u2013238","journal-title":"Trends Pharmacol Sci"},{"key":"8172_CR170","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0092-8674(80)90237-8","volume":"20","author":"PA Jones","year":"1980","unstructured":"Jones PA, Taylor SM (1980) Cellular differentiation, cytidine analogs and DNA methylation. Cell 20:85\u201393","journal-title":"Cell"},{"issue":"8","key":"8172_CR171","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00277-008-0477-9","volume":"87","author":"A Kuendgen","year":"2008","unstructured":"Kuendgen A, Lubbert M (2008) Current status of epigenetic treatment in myelodysplastic syndromes. Ann Hematol 87(8):601\u2013611","journal-title":"Ann Hematol"},{"key":"8172_CR172","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/jnci\/95.5.399","volume":"95","author":"JC Cheng","year":"2003","unstructured":"Cheng JC, Matsen CB, Gonzales FA et al (2003) Inhibition of DNA methylation and reactivation of silenced genes by zebularine. J Natl Cancer Inst 95:399\u2013409","journal-title":"J Natl Cancer Inst"},{"key":"8172_CR173","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.neuron.2007.02.022","volume":"53","author":"CA Miller","year":"2007","unstructured":"Miller CA, Sweatt JD (2007) Covalent modification of DNA regulates memory formation. Neuron 53:857\u2013869","journal-title":"Neuron"},{"key":"8172_CR174","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1128\/MCB.25.11.4727-4741.2005","volume":"25","author":"K Ghoshal","year":"2005","unstructured":"Ghoshal K, Datta J, Majumder S et al (2005) 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal. Mol Cell Biol 25:4727\u20134741","journal-title":"Mol Cell Biol"},{"key":"8172_CR175","doi-asserted-by":"crossref","first-page":"11797","DOI":"10.1073\/pnas.91.25.11797","volume":"91","author":"R Juttermann","year":"1994","unstructured":"Juttermann R, Li E, Jaenisch R (1994) Toxicity of 5-aza-2\u2032-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc Natl Acad Sci U S A 91:11797\u201311801","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8172_CR176","doi-asserted-by":"crossref","first-page":"6305","DOI":"10.1158\/0008-5472.CAN-04-2957","volume":"65","author":"B Brueckner","year":"2005","unstructured":"Brueckner B, Boy RG, Siedlecki P et al (2005) Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res 65:6305\u20136311","journal-title":"Cancer Res"},{"key":"8172_CR177","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.critrevonc.2006.07.010","volume":"61","author":"Y Oki","year":"2007","unstructured":"Oki Y, Aoki E, Issa JP (2007) Decitabine\u2014bedside to bench. Crit Rev Oncol Hematol 61:140\u2013152","journal-title":"Crit Rev Oncol Hematol"},{"key":"8172_CR178","first-page":"55","volume":"61","author":"AJ Weiss","year":"1977","unstructured":"Weiss AJ, Metter GE, Nealon TF et al (1977) Phase II study of 5-azacytidine in solid tumors. Cancer Treat Rep 61:55\u201358","journal-title":"Cancer Treat Rep"},{"key":"8172_CR179","doi-asserted-by":"crossref","first-page":"D599","DOI":"10.2741\/A630","volume":"6","author":"M Szyf","year":"2001","unstructured":"Szyf M (2001) The role of DNA methyltransferase 1 in growth control. Front Biosci 6:D599\u2013D609","journal-title":"Front Biosci"},{"key":"8172_CR180","first-page":"530","volume":"18","author":"LS Scheinbart","year":"1991","unstructured":"Scheinbart LS, Johnson MA, Gross LA, Edelstein SR, Richardson BC (1991) Procainamide inhibits DNA methyltransferase in a human T cell line. J Rheumatol 18:530\u2013534","journal-title":"J Rheumatol"},{"key":"8172_CR181","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1021\/jm7015705","volume":"51","author":"S Castellano","year":"2008","unstructured":"Castellano S, Kuck D, Sala M, Novellino E, Lyko F, Sbardella G (2008) Constrained analogues of procaine as novel small molecule inhibitors of DNA methyltransferase-1. J Med Chem 51:2321\u20132325","journal-title":"J Med Chem"},{"key":"8172_CR182","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/carcin\/bgl167","volume":"28","author":"S Milutinovic","year":"2007","unstructured":"Milutinovic S, D'Alessio AC, Detich N, Szyf M (2007) Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes. Carcinogenesis 28:560\u2013571","journal-title":"Carcinogenesis"},{"key":"8172_CR183","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/toxsci\/kfm177","volume":"100","author":"M Szyf","year":"2007","unstructured":"Szyf M (2007) The dynamic epigenome and its implications in toxicology. Toxicol Sci 100:7\u201323","journal-title":"Toxicol Sci"},{"key":"8172_CR184","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s10541-005-0147-7","volume":"70","author":"M Szyf","year":"2005","unstructured":"Szyf M (2005) DNA methylation and demethylation as targets for anticancer therapy. Biochemistry (Mosc) 70:533\u2013549","journal-title":"Biochemistry (Mosc)"},{"key":"8172_CR185","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3747\/co.v15i2.210","volume":"15","author":"M Szyf","year":"2008","unstructured":"Szyf M (2008) The role of DNA hypermethylation and demethylation in cancer and cancer therapy. Curr Oncol 15:72\u201375","journal-title":"Curr Oncol"},{"key":"8172_CR186","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/carcin\/bgh045","volume":"25","author":"PM Campbell","year":"2004","unstructured":"Campbell PM, Bovenzi V, Szyf M (2004) Methylated DNA-binding protein 2 antisense inhibitors suppress tumourigenesis of human cancer cell lines in vitro and in vivo. Carcinogenesis 25:499\u2013507","journal-title":"Carcinogenesis"},{"key":"8172_CR187","doi-asserted-by":"crossref","first-page":"31735","DOI":"10.1074\/jbc.M401669200","volume":"279","author":"P Pakneshan","year":"2004","unstructured":"Pakneshan P, Szyf M, Farias-Eisner R, Rabbani SA (2004) Reversal of the hypomethylation status of urokinase (uPA) promoter blocks breast cancer growth and metastasis. J Biol Chem 279:31735\u201331744","journal-title":"J Biol Chem"},{"key":"8172_CR188","doi-asserted-by":"crossref","first-page":"20812","DOI":"10.1074\/jbc.M211813200","volume":"278","author":"N Detich","year":"2003","unstructured":"Detich N, Hamm S, Just G, Knox JD, Szyf M (2003) The methyl donor S-adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-adenosylmethionine. J Biol Chem 278:20812\u201320820","journal-title":"J Biol Chem"},{"key":"8172_CR189","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.autrev.2008.07.043","volume":"8","author":"G Gorelik","year":"2009","unstructured":"Gorelik G, Richardson B (2009) Aberrant T cell ERK pathway signaling and chromatin structure in lupus. Autoimmun Rev 8:196\u2013198","journal-title":"Autoimmun Rev"},{"key":"8172_CR190","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00002826-198608000-00005","volume":"9","author":"MW Carney","year":"1986","unstructured":"Carney MW, Edeh J, Bottiglieri T, Reynolds EM, Toone BK (1986) Affective illness and S-adenosyl methionine: a preliminary report. Clin Neuropharmacol 9:379\u2013385","journal-title":"Clin Neuropharmacol"},{"key":"8172_CR191","first-page":"15","volume":"6","author":"G Gatto","year":"1986","unstructured":"Gatto G, Caleri D, Michelacci S, Sicuteri F (1986) Analgesizing effect of a methyl donor (S-adenosylmethionine) in migraine: an open clinical trial. Int J Clin Pharmacol Res 6:15\u201317","journal-title":"Int J Clin Pharmacol Res"},{"key":"8172_CR192","first-page":"132","volume":"28","author":"AL Williams","year":"2005","unstructured":"Williams AL, Girard C, Jui D, Sabina A, Katz DL (2005) S-adenosylmethionine (SAMe) as treatment for depression: a systematic review. Clin Invest Med 28:132\u2013139","journal-title":"Clin Invest Med"},{"key":"8172_CR193","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1080\/10408390701429526","volume":"48","author":"HJ Hosea Blewett","year":"2008","unstructured":"Hosea Blewett HJ (2008) Exploring the mechanisms behind S-adenosylmethionine (SAMe) in the treatment of osteoarthritis. Crit Rev Food Sci Nutr 48:458\u2013463","journal-title":"Crit Rev Food Sci Nutr"},{"key":"8172_CR194","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1139\/o06-090","volume":"84","author":"AC D'Alessio","year":"2006","unstructured":"D'Alessio AC, Szyf M (2006) Epigenetic tete-a-tete: the bilateral relationship between chromatin modifications and DNA methylation. Biochem Cell Biol 84:463\u2013476","journal-title":"Biochem Cell Biol"},{"key":"8172_CR195","doi-asserted-by":"crossref","first-page":"40778","DOI":"10.1074\/jbc.M103921200","volume":"276","author":"N Cervoni","year":"2001","unstructured":"Cervoni N, Szyf M (2001) Demethylase activity is directed by histone acetylation. J Biol Chem 276:40778\u201340787","journal-title":"J Biol Chem"},{"key":"8172_CR196","doi-asserted-by":"crossref","first-page":"25026","DOI":"10.1074\/jbc.M202256200","volume":"277","author":"N Cervoni","year":"2002","unstructured":"Cervoni N, Detich N, Seo SB, Chakravarti D, Szyf M (2002) The oncoprotein Set\/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing. J Biol Chem 277:25026\u201325031","journal-title":"J Biol Chem"},{"key":"8172_CR197","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nn1276","volume":"7","author":"IC Weaver","year":"2004","unstructured":"Weaver IC, Cervoni N, Champagne FA et al (2004) Epigenetic programming by maternal behavior. Nat Neurosci 7:847\u2013854","journal-title":"Nat Neurosci"},{"key":"8172_CR198","doi-asserted-by":"crossref","first-page":"2401S","DOI":"10.1093\/jn\/132.8.2401S","volume":"132","author":"BC Richardson","year":"2002","unstructured":"Richardson BC (2002) Role of DNA methylation in the regulation of cell function: autoimmunity, aging and cancer. J Nutr 132:2401S\u20132405S","journal-title":"J Nutr"},{"key":"8172_CR199","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1191\/0961203303lu321oa","volume":"12","author":"I Sekigawa","year":"2003","unstructured":"Sekigawa I, Okada M, Ogasawara H, Kaneko H, Hishikawa T, Hashimoto H (2003) DNA methylation in systemic lupus erythematosus. Lupus 12:79\u201385","journal-title":"Lupus"},{"key":"8172_CR200","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nrg2529","volume":"10","author":"N Arnheim","year":"2009","unstructured":"Arnheim N, Calabrese P (2009) Understanding what determines the frequency and pattern of human germline mutations. Nat Rev Genet 10:478\u2013488","journal-title":"Nat Rev Genet"},{"key":"8172_CR201","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1177\/0022034509335868","volume":"88","author":"SP Barros","year":"2009","unstructured":"Barros SP, Offenbacher S (2009) Epigenetics: connecting environment and genotype to phenotype and disease. J Dent Res 88:400\u2013408","journal-title":"J Dent Res"},{"key":"8172_CR202","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nrmicro2149","volume":"7","author":"LM Figueiredo","year":"2009","unstructured":"Figueiredo LM, Cross GA, Janzen CJ (2009) Epigenetic regulation in African trypanosomes: a new kid on the block. Nat Rev Microbiol 7:504\u2013513","journal-title":"Nat Rev Microbiol"},{"key":"8172_CR203","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaut.2009.03.007","volume":"33","author":"A Hewagama","year":"2009","unstructured":"Hewagama A, Richardson B (2009) The genetics and epigenetics of autoimmune diseases. J Autoimmun 33:3\u201311","journal-title":"J Autoimmun"},{"key":"8172_CR204","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2009.03.001","volume":"33","author":"P Invernizzi","year":"2009","unstructured":"Invernizzi P (2009) Future directions in genetic for autoimmune diseases. J Autoimmun 33:1\u20132","journal-title":"J Autoimmun"},{"key":"8172_CR205","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jaut.2009.03.005","volume":"33","author":"P Invernizzi","year":"2009","unstructured":"Invernizzi P, Pasini S, Selmi C, Gershwin ME, Podda M (2009) Female predominance and X chromosome defects in autoimmune diseases. J Autoimmun 33:12\u201316","journal-title":"J Autoimmun"},{"key":"8172_CR206","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jaut.2009.03.002","volume":"33","author":"D Larizza","year":"2009","unstructured":"Larizza D, Calcaterra V, Martinetti M (2009) Autoimmune stigmata in Turner syndrome: when lacks an X chromosome. J Autoimmun 33:25\u201330","journal-title":"J Autoimmun"},{"key":"8172_CR207","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jaut.2009.03.004","volume":"33","author":"L Persani","year":"2009","unstructured":"Persani L, Rossetti R, Cacciatore C, Bonomi M (2009) Primary ovarian insufficiency: X chromosome defects and autoimmunity. J Autoimmun 33:35\u201341","journal-title":"J Autoimmun"},{"key":"8172_CR208","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jaut.2009.03.006","volume":"33","author":"AH Sawalha","year":"2009","unstructured":"Sawalha AH, Harley JB, Scofield RH (2009) Autoimmunity and Klinefelter's syndrome: when men have two X chromosomes. J Autoimmun 33:31\u201334","journal-title":"J Autoimmun"},{"key":"8172_CR209","doi-asserted-by":"crossref","first-page":"7331","DOI":"10.4049\/jimmunol.0803917","volume":"182","author":"AD Wells","year":"2009","unstructured":"Wells AD (2009) New insights into the molecular basis of T cell anergy: anergy factors, avoidance sensors, and epigenetic imprinting. J Immunol 182:7331\u20137341","journal-title":"J Immunol"},{"key":"8172_CR210","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrg2564","volume":"10","author":"M Zernicka-Goetz","year":"2009","unstructured":"Zernicka-Goetz M, Morris SA, Bruce AW (2009) Making a firm decision: multifaceted regulation of cell fate in the early mouse embryo. Nat Rev Genet 10:467\u2013477","journal-title":"Nat Rev Genet"}],"container-title":["Clinical Reviews in Allergy &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-009-8172-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12016-009-8172-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-009-8172-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T15:25:00Z","timestamp":1710516300000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12016-009-8172-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,31]]},"references-count":210,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["8172"],"URL":"https:\/\/doi.org\/10.1007\/s12016-009-8172-8","relation":{},"ISSN":["1080-0549","1559-0267"],"issn-type":[{"value":"1080-0549","type":"print"},{"value":"1559-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,31]]}}}