{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:49:36Z","timestamp":1766450976462},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T00:00:00Z","timestamp":1292976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinic Rev Allerg Immunol"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1007\/s12016-010-8220-4","type":"journal-article","created":{"date-parts":[[2010,12,21]],"date-time":"2010-12-21T03:22:57Z","timestamp":1292901777000},"page":"169-178","source":"Crossref","is-referenced-by-count":22,"title":["Viruses and Cytotoxic T Lymphocytes in Type 1 Diabetes"],"prefix":"10.1007","volume":"41","author":[{"given":"Ken T.","family":"Coppieters","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias G.","family":"von Herrath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,12,22]]},"reference":[{"key":"8220_CR1","doi-asserted-by":"crossref","unstructured":"Van Belle TL CK, von Herrath MG (2011) Type 1 diabetes: etiology, immunology and therapeutic strategies. Physiol Rev (in press)","DOI":"10.1152\/physrev.00003.2010"},{"key":"8220_CR2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.2337\/diab.14.10.619","volume":"14","author":"W Gepts","year":"1965","unstructured":"Gepts W (1965) Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14:619\u2013633","journal-title":"Diabetes"},{"key":"8220_CR3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1365-2249.2008.03860.x","volume":"155","author":"A Willcox","year":"2009","unstructured":"Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2009) Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol 155:173\u2013181","journal-title":"Clin Exp Immunol"},{"key":"8220_CR4","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1073\/pnas.0700442104","volume":"104","author":"F Dotta","year":"2007","unstructured":"Dotta F, Censini S, van Halteren AG et al (2007) Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc Natl Acad Sci USA 104:5115\u20135120","journal-title":"Proc Natl Acad Sci USA"},{"key":"8220_CR5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1056\/NEJM198508083130604","volume":"313","author":"GF Bottazzo","year":"1985","unstructured":"Bottazzo GF, Dean BM, McNally JM, MacKay EH, Swift PG, Gamble DR (1985) In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med 313:353\u2013360","journal-title":"N Engl J Med"},{"key":"8220_CR6","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1172\/JCI116067","volume":"90","author":"A Hanninen","year":"1992","unstructured":"Hanninen A, Jalkanen S, Salmi M, Toikkanen S, Nikolakaros G, Simell O (1992) Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus. J Clin Invest 90:1901\u20131910","journal-title":"J Clin Invest"},{"key":"8220_CR7","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.4049\/jimmunol.153.3.1360","volume":"153","author":"N Somoza","year":"1994","unstructured":"Somoza N, Vargas F, Roura-Mir C et al (1994) Pancreas in recent onset insulin-dependent diabetes mellitus. Changes in HLA, adhesion molecules and autoantigens, restricted T cell receptor V beta usage, and cytokine profile. J Immunol 153:1360\u20131377","journal-title":"J Immunol"},{"key":"8220_CR8","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.2337\/db07-0416","volume":"56","author":"P In\u2019t Veld","year":"2007","unstructured":"In\u2019t Veld P, Lievens D, De Grijse J et al (2007) Screening for insulitis in adult autoantibody-positive organ donors. Diabetes 56:2400\u20132404","journal-title":"Diabetes"},{"key":"8220_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.2006.03244.x","volume":"148","author":"TP Lorenzo Di","year":"2007","unstructured":"Di Lorenzo TP, Peakman M, Roep BO (2007) Translational mini-review series on type 1 diabetes: systematic analysis of T cell epitopes in autoimmune diabetes. Clin Exp Immunol 148:1\u201316","journal-title":"Clin Exp Immunol"},{"key":"8220_CR10","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.2337\/db09-1486","volume":"59","author":"JH Velthuis","year":"2010","unstructured":"Velthuis JH, Unger WW, Abreu JR et al (2010) Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers. Diabetes 59:1721\u20131730","journal-title":"Diabetes"},{"key":"8220_CR11","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.2337\/diabetes.52.11.2647","volume":"52","author":"C Panagiotopoulos","year":"2003","unstructured":"Panagiotopoulos C, Qin H, Tan R, Verchere CB (2003) Identification of a beta-cell-specific HLA class I restricted epitope in type 1 diabetes. Diabetes 52:2647\u20132651","journal-title":"Diabetes"},{"key":"8220_CR12","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1196\/annals.1337.004","volume":"1037","author":"S Rathmann","year":"2004","unstructured":"Rathmann S, Rajasalu T, Rosinger S et al (2004) Preproinsulin-specific CD8+ T cells secrete IFNgamma in human type 1 diabetes. Ann NY Acad Sci 1037:22\u201325","journal-title":"Ann NY Acad Sci"},{"key":"8220_CR13","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1084\/jem.181.5.1923","volume":"181","author":"P Panina-Bordignon","year":"1995","unstructured":"Panina-Bordignon P, Lang R, van Endert PM et al (1995) Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes. J Exp Med 181:1923\u20131927","journal-title":"J Exp Med"},{"key":"8220_CR14","doi-asserted-by":"crossref","first-page":"18425","DOI":"10.1073\/pnas.0508621102","volume":"102","author":"GG Pinkse","year":"2005","unstructured":"Pinkse GG, Tysma OH, Bergen CA et al (2005) Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes. Proc Natl Acad Sci USA 102:18425\u201318430","journal-title":"Proc Natl Acad Sci USA"},{"key":"8220_CR15","doi-asserted-by":"crossref","first-page":"10581","DOI":"10.1073\/pnas.0504230102","volume":"102","author":"A Toma","year":"2005","unstructured":"Toma A, Haddouk S, Briand JP et al (2005) Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients. Proc Natl Acad Sci USA 102:10581\u201310586","journal-title":"Proc Natl Acad Sci USA"},{"key":"8220_CR16","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.2337\/db06-0065","volume":"55","author":"Q Ouyang","year":"2006","unstructured":"Ouyang Q, Standifer NE, Qin H et al (2006) Recognition of HLA class I-restricted beta-cell epitopes in type 1 diabetes. Diabetes 55:3068\u20133074","journal-title":"Diabetes"},{"key":"8220_CR17","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.4049\/jimmunol.179.9.5785","volume":"179","author":"P Monti","year":"2007","unstructured":"Monti P, Scirpoli M, Rigamonti A et al (2007) Evidence for in vivo primed and expanded autoreactive T cells as a specific feature of patients with type 1 diabetes. J Immunol 179:5785\u20135792","journal-title":"J Immunol"},{"key":"8220_CR18","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.clim.2008.01.015","volume":"127","author":"I Jarchum","year":"2008","unstructured":"Jarchum I, Nichol L, Trucco M, Santamaria P, DiLorenzo TP (2008) Identification of novel IGRP epitopes targeted in type 1 diabetes patients. Clin Immunol 127:359\u2013365","journal-title":"Clin Immunol"},{"key":"8220_CR19","doi-asserted-by":"crossref","first-page":"394","DOI":"10.2337\/db08-0599","volume":"58","author":"A Toma","year":"2009","unstructured":"Toma A, Laika T, Haddouk S et al (2009) Recognition of human proinsulin leader sequence by class I-restricted T-cells in HLA-A*0201 transgenic mice and in human type 1 diabetes. Diabetes 58:394\u2013402","journal-title":"Diabetes"},{"key":"8220_CR20","doi-asserted-by":"crossref","first-page":"613","DOI":"10.2337\/db06-1419","volume":"56","author":"R Mallone","year":"2007","unstructured":"Mallone R, Martinuzzi E, Blancou P et al (2007) CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetes. Diabetes 56:613\u2013621","journal-title":"Diabetes"},{"key":"8220_CR21","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s10875-008-9177-4","volume":"28","author":"C Baker","year":"2008","unstructured":"Baker C, de Marquesini LG Petrich, Bishop AJ, Hedges AJ, Dayan CM, Wong FS (2008) Human CD8 responses to a complete epitope set from preproinsulin: implications for approaches to epitope discovery. J Clin Immunol 28:350\u2013360","journal-title":"J Clin Immunol"},{"key":"8220_CR22","first-page":"3390","volume":"118","author":"A Skowera","year":"2008","unstructured":"Skowera A, Ellis RJ, Varela-Calvino R et al (2008) CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. J Clin Invest 118:3390\u20133402","journal-title":"J Clin Invest"},{"key":"8220_CR23","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.2337\/db07-1594","volume":"57","author":"E Martinuzzi","year":"2008","unstructured":"Martinuzzi E, Novelli G, Scotto M et al (2008) The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment. Diabetes 57:1312\u20131320","journal-title":"Diabetes"},{"key":"8220_CR24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.clim.2009.09.005","volume":"134","author":"S Cernea","year":"2010","unstructured":"Cernea S, Herold KC (2010) Monitoring of antigen-specific CD8 T cells in patients with type 1 diabetes treated with antiCD3 monoclonal antibodies. Clin Immunol 134:121\u2013129","journal-title":"Clin Immunol"},{"key":"8220_CR25","doi-asserted-by":"crossref","first-page":"e2435","DOI":"10.1371\/journal.pone.0002435","volume":"3","author":"VA Huurman","year":"2008","unstructured":"Huurman VA, Hilbrands R, Pinkse GG et al (2008) Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation. PLoS ONE 3:e2435","journal-title":"PLoS ONE"},{"key":"8220_CR26","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1172\/JCI200316409","volume":"111","author":"JD Trudeau","year":"2003","unstructured":"Trudeau JD, Kelly-Smith C, Verchere CB et al (2003) Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood. J Clin Invest 111:217\u2013223","journal-title":"J Clin Invest"},{"key":"8220_CR27","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.4049\/jimmunol.178.3.1388","volume":"178","author":"CP Wong","year":"2007","unstructured":"Wong CP, Stevens R, Long B et al (2007) Identical beta cell-specific CD8(+) T cell clonotypes typically reside in both peripheral blood lymphocyte and pancreatic islets. J Immunol 178:1388\u20131395","journal-title":"J Immunol"},{"key":"8220_CR28","doi-asserted-by":"crossref","first-page":"5430","DOI":"10.4049\/jimmunol.180.8.5430","volume":"180","author":"E Enee","year":"2008","unstructured":"Enee E, Martinuzzi E, Blancou P, Bach JM, Mallone R, van Endert P (2008) Equivalent specificity of peripheral blood and islet-infiltrating CD8+ T lymphocytes in spontaneously diabetic HLA-A2 transgenic NOD mice. J Immunol 180:5430\u20135438","journal-title":"J Immunol"},{"key":"8220_CR29","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/s00125-008-1237-z","volume":"52","author":"JH Velthuis","year":"2009","unstructured":"Velthuis JH, Unger WW, van der Slik AR et al (2009) Accumulation of autoreactive effector T cells and allo-specific regulatory T cells in the pancreas allograft of a type 1 diabetic recipient. Diabetologia 52:494\u2013503","journal-title":"Diabetologia"},{"key":"8220_CR30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0065-2776(08)00804-3","volume":"100","author":"S Tsai","year":"2008","unstructured":"Tsai S, Shameli A, Santamaria P (2008) CD8+ T cells in type 1 diabetes. Adv Immunol 100:79\u2013124","journal-title":"Adv Immunol"},{"key":"8220_CR31","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.clim.2009.04.013","volume":"132","author":"NE Standifer","year":"2009","unstructured":"Standifer NE, Burwell EA, Gersuk VH, Greenbaum CJ, Nepom GT (2009) Changes in autoreactive T cell avidity during type 1 diabetes development. Clin Immunol 132:312\u2013320","journal-title":"Clin Immunol"},{"key":"8220_CR32","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.2337\/diabetes.53.8.1987","volume":"53","author":"H Reijonen","year":"2004","unstructured":"Reijonen H, Mallone R, Heninger AK et al (2004) GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes. Diabetes 53:1987\u20131994","journal-title":"Diabetes"},{"key":"8220_CR33","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/35021081","volume":"406","author":"A Amrani","year":"2000","unstructured":"Amrani A, Verdaguer J, Serra P, Tafuro S, Tan R, Santamaria P (2000) Progression of autoimmune diabetes driven by avidity maturation of a T-cell population. Nature 406:739\u2013742","journal-title":"Nature"},{"key":"8220_CR34","doi-asserted-by":"crossref","unstructured":"Oikarinen S, Martiskainen M, Tauriainen S, et al (2010) Enterovirus RNA in blood is linked to the development of type 1 diabetes. Diabetes (in press)","DOI":"10.2337\/db10-0186"},{"issue":"12","key":"8220_CR35","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.2337\/db10-0866","volume":"59","author":"LC Stene","year":"2010","unstructured":"Stene LC, Oikarinen S, Hyoty H et al (2010) Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the diabetes and autoimmunity study in the young (DAISY). Diabetes 59(12):3174\u20133180","journal-title":"Diabetes"},{"key":"8220_CR36","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nrendo.2010.27","volume":"6","author":"D Hober","year":"2010","unstructured":"Hober D, Sauter P (2010) Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host. Nat Rev Endocrinol 6:279\u2013289","journal-title":"Nat Rev Endocrinol"},{"key":"8220_CR37","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.phrs.2008.03.009","volume":"57","author":"G Mazzaglia","year":"2008","unstructured":"Mazzaglia G, Yurgin N, Boye KS et al (2008) Prevalence and antihyperglycemic prescribing trends for patients with type 2 diabetes in Italy: a 4-year retrospective study from national primary care data. Pharmacol Res 57:358\u2013363","journal-title":"Pharmacol Res"},{"key":"8220_CR38","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s00125-009-1276-0","volume":"52","author":"SJ Richardson","year":"2009","unstructured":"Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009) The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes. Diabetologia 52:1143\u20131151","journal-title":"Diabetologia"},{"key":"8220_CR39","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S0140-6736(87)91128-7","volume":"2","author":"AK Foulis","year":"1987","unstructured":"Foulis AK, Farquharson MA, Meager A (1987) Immunoreactive alpha-interferon in insulin-secreting beta cells in type 1 diabetes mellitus. Lancet 2:1423\u20131427","journal-title":"Lancet"},{"key":"8220_CR40","doi-asserted-by":"crossref","first-page":"778","DOI":"10.2337\/diabetes.27.7.778","volume":"27","author":"JW Yoon","year":"1978","unstructured":"Yoon JW, Onodera T, Jenson AB, Notkins AL (1978) Virus-induced diabetes mellitus. XI. Replication of coxsackie B3 virus in human pancreatic beta cell cultures. Diabetes 27:778\u2013781","journal-title":"Diabetes"},{"key":"8220_CR41","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.virol.2004.06.049","volume":"329","author":"KM Drescher","year":"2004","unstructured":"Drescher KM, Kono K, Bopegamage S, Carson SD, Tracy S (2004) Coxsackievirus B3 infection and type 1 diabetes development in NOD mice: insulitis determines susceptibility of pancreatic islets to virus infection. Virology 329:381\u2013394","journal-title":"Virology"},{"key":"8220_CR42","doi-asserted-by":"crossref","first-page":"5637","DOI":"10.1128\/JVI.02361-05","volume":"80","author":"T Kanno","year":"2006","unstructured":"Kanno T, Kim K, Kono K, Drescher KM, Chapman NM, Tracy S (2006) Group B coxsackievirus diabetogenic phenotype correlates with replication efficiency. J Virol 80:5637\u20135643","journal-title":"J Virol"},{"key":"8220_CR43","doi-asserted-by":"crossref","first-page":"708","DOI":"10.2337\/diabetes.49.5.708","volume":"49","author":"DV Serreze","year":"2000","unstructured":"Serreze DV, Ottendorfer EW, Ellis TM, Gauntt CJ, Atkinson MA (2000) Acceleration of type 1 diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets. Diabetes 49:708\u2013711","journal-title":"Diabetes"},{"key":"8220_CR44","first-page":"1515","volume":"119","author":"CM Filippi","year":"2009","unstructured":"Filippi CM, Estes EA, Oldham JE, von Herrath MG (2009) Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice. J Clin Invest 119:1515\u20131523","journal-title":"J Clin Invest"},{"key":"8220_CR45","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1900\/RDS.2009.6.85","volume":"6","author":"KT Coppieters","year":"2009","unstructured":"Coppieters KT, von Herrath MG (2009) Histopathology of type 1 diabetes: old paradigms and new insights. Rev Diabet Stud 6:85\u201396","journal-title":"Rev Diabet Stud"},{"key":"8220_CR46","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0092-8674(91)90165-U","volume":"65","author":"MB Oldstone","year":"1991","unstructured":"Oldstone MB, Nerenberg M, Southern P, Price J, Lewicki H (1991) Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response. Cell 65:319\u2013331","journal-title":"Cell"},{"key":"8220_CR47","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0092-8674(91)90164-T","volume":"65","author":"PS Ohashi","year":"1991","unstructured":"Ohashi PS, Oehen S, Buerki K et al (1991) Ablation of \u201ctolerance\u201d and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65:305\u2013317","journal-title":"Cell"},{"key":"8220_CR48","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.2337\/db05-0062","volume":"56","author":"MM Martinic","year":"2007","unstructured":"Martinic MM, Juedes AE, Bresson D et al (2007) Minimal impact of a de novo-expressed beta-cell autoantigen on spontaneous diabetes development in NOD mice. Diabetes 56:1059\u20131068","journal-title":"Diabetes"},{"key":"8220_CR49","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.4049\/jimmunol.0900709","volume":"184","author":"MC Honeyman","year":"2010","unstructured":"Honeyman MC, Stone NL, Falk BA, Nepom G, Harrison LC (2010) Evidence for molecular mimicry between human T cell epitopes in rotavirus and pancreatic islet autoantigens. J Immunol 184:2204\u20132210","journal-title":"J Immunol"},{"key":"8220_CR50","doi-asserted-by":"crossref","first-page":"3988","DOI":"10.1073\/pnas.071050898","volume":"98","author":"HS Hiemstra","year":"2001","unstructured":"Hiemstra HS, Schloot NC, van Veelen PA et al (2001) Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase. Proc Natl Acad Sci USA 98:3988\u20133991","journal-title":"Proc Natl Acad Sci USA"},{"key":"8220_CR51","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/jmv.2151","volume":"66","author":"T Harkonen","year":"2002","unstructured":"Harkonen T, Lankinen H, Davydova B, Hovi T, Roivainen M (2002) Enterovirus infection can induce immune responses that cross-react with beta-cell autoantigen tyrosine phosphatase IA-2\/IAR. J Med Virol 66:340\u2013350","journal-title":"J Med Virol"},{"key":"8220_CR52","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nm0798-781","volume":"4","author":"MS Horwitz","year":"1998","unstructured":"Horwitz MS, Bradley LM, Harbertson J, Krahl T, Lee J, Sarvetnick N (1998) Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry. Nat Med 4:781\u2013785","journal-title":"Nat Med"},{"key":"8220_CR53","doi-asserted-by":"crossref","first-page":"9317","DOI":"10.1073\/pnas.0913835107","volume":"107","author":"J Wang","year":"2010","unstructured":"Wang J, Tsai S, Shameli A, Yamanouchi J, Alkemade G, Santamaria P (2010) In situ recognition of autoantigen as an essential gatekeeper in autoimmune CD8+ T cell inflammation. Proc Natl Acad Sci USA 107:9317\u20139322","journal-title":"Proc Natl Acad Sci USA"},{"key":"8220_CR54","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.immuni.2009.07.008","volume":"31","author":"GP Lennon","year":"2009","unstructured":"Lennon GP, Bettini M, Burton AR et al (2009) T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event. Immunity 31:643\u2013653","journal-title":"Immunity"},{"key":"8220_CR55","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1084\/jem.20021378","volume":"197","author":"AY Savinov","year":"2003","unstructured":"Savinov AY, Wong FS, Stonebraker AC, Chervonsky AV (2003) Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells. J Exp Med 197:643\u2013656","journal-title":"J Exp Med"},{"key":"8220_CR56","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1182\/blood-2003-08-2717","volume":"103","author":"FM Marelli-Berg","year":"2004","unstructured":"Marelli-Berg FM, James MJ, Dangerfield J et al (2004) Cognate recognition of the endothelium induces HY-specific CD8+ T-lymphocyte transendothelial migration (diapedesis) in vivo. Blood 103:3111\u20133116","journal-title":"Blood"},{"key":"8220_CR57","doi-asserted-by":"crossref","first-page":"6727","DOI":"10.4049\/jimmunol.173.11.6727","volume":"173","author":"SM Lieberman","year":"2004","unstructured":"Lieberman SM, Takaki T, Han B, Santamaria P, Serreze DV, DiLorenzo TP (2004) Individual nonobese diabetic mice exhibit unique patterns of CD8+ T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia myotonica kinase. J Immunol 173:6727\u20136734","journal-title":"J Immunol"},{"key":"8220_CR58","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.2337\/diabetes.49.11.1801","volume":"49","author":"S Seewaldt","year":"2000","unstructured":"Seewaldt S, Thomas HE, Ejrnaes M et al (2000) Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes. Diabetes 49:1801\u20131809","journal-title":"Diabetes"},{"key":"8220_CR59","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.immuni.2006.06.009","volume":"25","author":"D Zehn","year":"2006","unstructured":"Zehn D, Bevan MJ (2006) T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity 25:261\u2013270","journal-title":"Immunity"},{"key":"8220_CR60","doi-asserted-by":"crossref","first-page":"6838","DOI":"10.4049\/jimmunol.171.12.6838","volume":"171","author":"U Christen","year":"2003","unstructured":"Christen U, McGavern DB, Luster AD, von Herrath MG, Oldstone MB (2003) Among CXCR3 chemokines, IFN-gamma-inducible protein of 10\u00a0kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease. J Immunol 171:6838\u20136845","journal-title":"J Immunol"},{"key":"8220_CR61","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1172\/JCI117689","volume":"95","author":"MS Lee","year":"1995","unstructured":"Lee MS, von Herrath M, Reiser H, Oldstone MB, Sarvetnick N (1995) Sensitization to self (virus) antigen by in situ expression of murine interferon-gamma. J Clin Invest 95:486\u2013492","journal-title":"J Clin Invest"},{"key":"8220_CR62","doi-asserted-by":"crossref","first-page":"6688","DOI":"10.1073\/pnas.1131954100","volume":"100","author":"EE Hamilton-Williams","year":"2003","unstructured":"Hamilton-Williams EE, Palmer SE, Charlton B, Slattery RM (2003) Beta cell MHC class I is a late requirement for diabetes. Proc Natl Acad Sci USA 100:6688\u20136693","journal-title":"Proc Natl Acad Sci USA"},{"key":"8220_CR63","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nri911","volume":"2","author":"JA Trapani","year":"2002","unstructured":"Trapani JA, Smyth MJ (2002) Functional significance of the perforin\/granzyme cell death pathway. Nat Rev Immunol 2:735\u2013747","journal-title":"Nat Rev Immunol"},{"key":"8220_CR64","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1084\/jem.186.7.989","volume":"186","author":"D Kagi","year":"1997","unstructured":"Kagi D, Odermatt B, Seiler P, Zinkernagel RM, Mak TW, Hengartner H (1997) Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice. J Exp Med 186:989\u2013997","journal-title":"J Exp Med"},{"key":"8220_CR65","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/cdd.2009.165","volume":"17","author":"HE Thomas","year":"2010","unstructured":"Thomas HE, Trapani JA, Kay TW (2010) The role of perforin and granzymes in diabetes. Cell Death Differ 17:577\u2013585","journal-title":"Cell Death Differ"},{"key":"8220_CR66","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1084\/jem.183.5.2143","volume":"183","author":"D Kagi","year":"1996","unstructured":"Kagi D, Odermatt B, Ohashi PS, Zinkernagel RM, Hengartner H (1996) Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity. J Exp Med 183:2143\u20132152","journal-title":"J Exp Med"},{"key":"8220_CR67","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1073\/pnas.0237359100","volume":"100","author":"AY Savinov","year":"2003","unstructured":"Savinov AY, Tcherepanov A, Green EA, Flavell RA, Chervonsky AV (2003) Contribution of Fas to diabetes development. Proc Natl Acad Sci USA 100:628\u2013632","journal-title":"Proc Natl Acad Sci USA"},{"key":"8220_CR68","doi-asserted-by":"crossref","first-page":"293","DOI":"10.4049\/jimmunol.175.1.293","volume":"175","author":"J Allison","year":"2005","unstructured":"Allison J, Thomas HE, Catterall T, Kay TW, Strasser A (2005) Transgenic expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis and reduces spontaneous diabetes in nonobese diabetic mice. J Immunol 175:293\u2013301","journal-title":"J Immunol"},{"key":"8220_CR69","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1084\/jem.185.3.531","volume":"185","author":"MG Herrath von","year":"1997","unstructured":"von Herrath MG, Oldstone MB (1997) Interferon-gamma is essential for destruction of beta cells and development of insulin-dependent diabetes mellitus. J Exp Med 185:531\u2013539","journal-title":"J Exp Med"},{"key":"8220_CR70","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2337\/diabetes.51.2.311","volume":"51","author":"HE Thomas","year":"2002","unstructured":"Thomas HE, Darwiche R, Corbett JA, Kay TW (2002) Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production. Diabetes 51:311\u2013316","journal-title":"Diabetes"},{"key":"8220_CR71","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1172\/JCI2899","volume":"102","author":"HE Thomas","year":"1998","unstructured":"Thomas HE, Parker JL, Schreiber RD, Kay TW (1998) IFN-gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes. J Clin Invest 102:1249\u20131257","journal-title":"J Clin Invest"},{"key":"8220_CR72","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1172\/JCI8185","volume":"105","author":"A Amrani","year":"2000","unstructured":"Amrani A, Verdaguer J, Thiessen S, Bou S, Santamaria P (2000) IL-1alpha, IL-1beta, and IFN-gamma mark beta cells for Fas-dependent destruction by diabetogenic CD4(+) T lymphocytes. J Clin Invest 105:459\u2013468","journal-title":"J Clin Invest"},{"key":"8220_CR73","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.humimm.2008.06.008","volume":"69","author":"PD Campbell","year":"2008","unstructured":"Campbell PD, Estella E, Dudek NL et al (2008) Cytotoxic T-lymphocyte-mediated killing of human pancreatic islet cells in vitro. Hum Immunol 69:543\u2013551","journal-title":"Hum Immunol"},{"key":"8220_CR74","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.2337\/db06-0129","volume":"55","author":"E Estella","year":"2006","unstructured":"Estella E, McKenzie MD, Catterall T et al (2006) Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid. Diabetes 55:2212\u20132219","journal-title":"Diabetes"},{"key":"8220_CR75","doi-asserted-by":"crossref","first-page":"727","DOI":"10.2337\/diabetes.47.5.727","volume":"47","author":"AC Loweth","year":"1998","unstructured":"Loweth AC, Williams GT, James RF, Scarpello JH, Morgan NG (1998) Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation. Diabetes 47:727\u2013732","journal-title":"Diabetes"},{"key":"8220_CR76","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00125-005-0069-3","volume":"49","author":"JJ Meier","year":"2006","unstructured":"Meier JJ, Ritzel RA, Maedler K, Gurlo T, Butler PC (2006) Increased vulnerability of newly forming beta cells to cytokine-induced cell death. Diabetologia 49:83\u201389","journal-title":"Diabetologia"},{"key":"8220_CR77","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1007\/s001250051446","volume":"42","author":"M Moriwaki","year":"1999","unstructured":"Moriwaki M, Itoh N, Miyagawa J et al (1999) Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recent-onset Type I diabetes mellitus. Diabetologia 42:1332\u20131340","journal-title":"Diabetologia"},{"key":"8220_CR78","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1007\/s00125-005-1949-2","volume":"48","author":"JJ Meier","year":"2005","unstructured":"Meier JJ, Bhushan A, Butler AE, Rizza RA, Butler PC (2005) Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? Diabetologia 48:2221\u20132228","journal-title":"Diabetologia"},{"key":"8220_CR79","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1007\/s00125-007-0794-x","volume":"50","author":"AE Butler","year":"2007","unstructured":"Butler AE, Galasso R, Meier JJ, Basu R, Rizza RA, Butler PC (2007) Modestly increased beta cell apoptosis but no increased beta cell replication in recent-onset type 1 diabetic patients who died of diabetic ketoacidosis. Diabetologia 50:2323\u20132331","journal-title":"Diabetologia"},{"key":"8220_CR80","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1084\/jem.186.8.1193","volume":"186","author":"G Stassi","year":"1997","unstructured":"Stassi G, De Maria R, Trucco G et al (1997) Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus. J Exp Med 186:1193\u20131200","journal-title":"J Exp Med"},{"key":"8220_CR81","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1073\/pnas.0510790103","volume":"103","author":"O Cabrera","year":"2006","unstructured":"Cabrera O, Berman DM, Kenyon NS, Ricordi C, Berggren PO, Caicedo A (2006) The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci USA 103:2334\u20132339","journal-title":"Proc Natl Acad Sci USA"},{"key":"8220_CR82","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1172\/JCI116835","volume":"92","author":"N Itoh","year":"1993","unstructured":"Itoh N, Hanafusa T, Miyazaki A et al (1993) Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. J Clin Invest 92:2313\u20132322","journal-title":"J Clin Invest"},{"key":"8220_CR83","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.2337\/db09-0503","volume":"59","author":"TI Tree","year":"2010","unstructured":"Tree TI, Lawson J, Edwards H et al (2010) Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression. Diabetes 59:1451\u20131460","journal-title":"Diabetes"},{"key":"8220_CR84","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1172\/JCI200317166","volume":"111","author":"NR Martinez","year":"2003","unstructured":"Martinez NR, Augstein P, Moustakas AK et al (2003) Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide. J Clin Invest 111:1365\u20131371","journal-title":"J Clin Invest"},{"key":"8220_CR85","doi-asserted-by":"crossref","first-page":"918","DOI":"10.2337\/db07-0226","volume":"57","author":"H Tsui","year":"2008","unstructured":"Tsui H, Chan Y, Tang L et al (2008) Targeting of pancreatic glia in type 1 diabetes. Diabetes 57:918\u2013928","journal-title":"Diabetes"},{"key":"8220_CR86","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1073\/pnas.91.2.444","volume":"91","author":"P Aichele","year":"1994","unstructured":"Aichele P, Kyburz D, Ohashi PS et al (1994) Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model. Proc Natl Acad Sci USA 91:444\u2013448","journal-title":"Proc Natl Acad Sci USA"},{"key":"8220_CR87","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1172\/JCI27191","volume":"116","author":"D Bresson","year":"2006","unstructured":"Bresson D, Togher L, Rodrigo E et al (2006) Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J Clin Invest 116:1371\u20131381","journal-title":"J Clin Invest"},{"key":"8220_CR88","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1172\/JCI23961","volume":"115","author":"B Bisikirska","year":"2005","unstructured":"Bisikirska B, Colgan J, Luban J, Bluestone JA, Herold KC (2005) TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs. J Clin Invest 115:2904\u20132913","journal-title":"J Clin Invest"},{"key":"8220_CR89","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.immuni.2010.03.015","volume":"32","author":"S Tsai","year":"2010","unstructured":"Tsai S, Shameli A, Yamanouchi J et al (2010) Reversal of autoimmunity by boosting memory-like autoregulatory T cells. Immunity 32:568\u2013580","journal-title":"Immunity"},{"key":"8220_CR90","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.4049\/jimmunol.0903931","volume":"184","author":"BG Vincent","year":"2010","unstructured":"Vincent BG, Young EF, Buntzman AS et al (2010) Toxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in nonobese diabetic mice. J Immunol 184:4196\u20134204","journal-title":"J Immunol"}],"container-title":["Clinical Reviews in Allergy & Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-010-8220-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12016-010-8220-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-010-8220-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T15:28:16Z","timestamp":1685892496000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12016-010-8220-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,22]]},"references-count":90,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["8220"],"URL":"https:\/\/doi.org\/10.1007\/s12016-010-8220-4","relation":{},"ISSN":["1080-0549","1559-0267"],"issn-type":[{"value":"1080-0549","type":"print"},{"value":"1559-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,22]]}}}