{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T18:49:51Z","timestamp":1773427791535,"version":"3.50.1"},"reference-count":136,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,6,14]],"date-time":"2012-06-14T00:00:00Z","timestamp":1339632000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinic Rev Allerg Immunol"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1007\/s12016-012-8323-1","type":"journal-article","created":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T14:03:31Z","timestamp":1339596211000},"page":"220-229","source":"Crossref","is-referenced-by-count":21,"title":["Immunological Orchestration of Liver Fibrosis"],"prefix":"10.1007","volume":"43","author":[{"given":"Hajime","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick S. C.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom P.","family":"Kenny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Eric","family":"Gershwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher L.","family":"Bowlus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,6,14]]},"reference":[{"key":"8323_CR1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1161\/CIRCRESAHA.108.192492","volume":"104","author":"E Rooij van","year":"2009","unstructured":"van Rooij E, Olson EN (2009) Searching for miR-acles in cardiac fibrosis. Circ Res 104:138\u2013140","journal-title":"Circ Res"},{"key":"8323_CR2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.ki.5000054","volume":"69","author":"Y Liu","year":"2006","unstructured":"Liu Y (2006) Renal fibrosis: new insights into the pathogenesis and therapeutics. Kidney Int 69:213\u2013217","journal-title":"Kidney Int"},{"key":"8323_CR3","first-page":"1","volume":"59","author":"AM Mini\u00f1o","year":"2011","unstructured":"Mini\u00f1o AM, Murphy SL, Xu J, Kochanek K (2011) Deaths: final data for 2008. Natl Vital Stat Rep 59:1\u2013152","journal-title":"Natl Vital Stat Rep"},{"key":"8323_CR4","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI30542","volume":"117","author":"JP Iredale","year":"2007","unstructured":"Iredale JP (2007) Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest 117:539\u2013548","journal-title":"J Clin Invest"},{"key":"8323_CR5","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1517\/14728222.8.5.423","volume":"8","author":"JA Fallowfield","year":"2004","unstructured":"Fallowfield JA, Iredale JP (2004) Targeted treatments for cirrhosis. Expert Opin Ther Targets 8:423\u2013435","journal-title":"Expert Opin Ther Targets"},{"key":"8323_CR6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","volume":"115","author":"R Bataller","year":"2005","unstructured":"Bataller R, Brenner DA (2005) Liver fibrosis. J Clin Invest 115:209\u2013218","journal-title":"J Clin Invest"},{"key":"8323_CR7","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/hep.21459","volume":"45","author":"SL Friedman","year":"2007","unstructured":"Friedman SL, Rockey DC, Bissell DM (2007) Hepatic fibrosis 2006: report of the Third AASLD Single Topic Conference. Hepatology 45:242\u2013249","journal-title":"Hepatology"},{"key":"8323_CR8","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.dld.2004.01.003","volume":"36","author":"M Pinzani","year":"2004","unstructured":"Pinzani M, Rombouts K (2004) Liver fibrosis: from the bench to clinical targets. Dig Liver Dis 36:231\u2013242","journal-title":"Dig Liver Dis"},{"key":"8323_CR9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cca.2005.06.014","volume":"364","author":"S Tsukada","year":"2006","unstructured":"Tsukada S, Parsons CJ, Rippe RA (2006) Mechanisms of liver fibrosis. Clin Chim Acta 364:33\u201360","journal-title":"Clin Chim Acta"},{"key":"8323_CR10","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","volume":"32","author":"S Gordon","year":"2010","unstructured":"Gordon S, Martinez FO (2010) Alternative activation of macrophages: mechanism and functions. Immunity 32:593\u2013604","journal-title":"Immunity"},{"key":"8323_CR11","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1172\/JCI7325","volume":"104","author":"MG Chiaramonte","year":"1999","unstructured":"Chiaramonte MG, Donaldson DD, Cheever AW, Wynn TA (1999) An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J Clin Invest 104:777\u2013785","journal-title":"J Clin Invest"},{"key":"8323_CR12","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/hep.22934","volume":"50","author":"HL Weng","year":"2009","unstructured":"Weng HL, Liu Y, Chen JL et al (2009) The etiology of liver damage imparts cytokines transforming growth factor beta1 or interleukin-13 as driving forces in fibrogenesis. Hepatology 50:230\u2013243","journal-title":"Hepatology"},{"key":"8323_CR13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","volume":"214","author":"TA Wynn","year":"2008","unstructured":"Wynn TA (2008) Cellular and molecular mechanisms of fibrosis. J Pathol 214:199\u2013210","journal-title":"J Pathol"},{"key":"8323_CR14","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/hep.22680","volume":"49","author":"A Lemmers","year":"2009","unstructured":"Lemmers A, Moreno C, Gustot T et al (2009) The interleukin-17 pathway is involved in human alcoholic liver disease. Hepatology 49:646\u2013657","journal-title":"Hepatology"},{"key":"8323_CR15","doi-asserted-by":"crossref","first-page":"e18909","DOI":"10.1371\/journal.pone.0018909","volume":"6","author":"L Zhao","year":"2011","unstructured":"Zhao L, Tang Y, You Z et al (2011) Interleukin-17 contributes to the pathogenesis of autoimmune hepatitis through inducing hepatic interleukin-6 expression. PLoS One 6:e18909","journal-title":"PLoS One"},{"key":"8323_CR16","first-page":"385","volume":"27","author":"L Wang","year":"2011","unstructured":"Wang L, Chen S, Xu K (2011) IL-17 expression is correlated with hepatitis B related liver diseases and fibrosis. Int J Mol Med 27:385\u2013392","journal-title":"Int J Mol Med"},{"key":"8323_CR17","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1600-6143.2011.03458.x","volume":"11","author":"HI Basha","year":"2011","unstructured":"Basha HI, Subramanian V, Seetharam A et al (2011) Characterization of HCV-specific CD4 + Th17 immunity in recurrent hepatitis C-induced liver allograft fibrosis. Am J Transplant 11:775\u2013785","journal-title":"Am J Transplant"},{"key":"8323_CR18","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1053\/j.gastro.2005.10.055","volume":"130","author":"S Radaeva","year":"2006","unstructured":"Radaeva S, Sun R, Jaruga B, Nguyen VT, Tian Z, Gao B (2006) Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Gastroenterology 130:435\u2013452","journal-title":"Gastroenterology"},{"key":"8323_CR19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jhep.2005.12.025","volume":"45","author":"A Melhem","year":"2006","unstructured":"Melhem A, Muhanna N, Bishara A et al (2006) Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC. J Hepatol 45:60\u201371","journal-title":"J Hepatol"},{"key":"8323_CR20","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1053\/j.gastro.2005.12.048","volume":"130","author":"WZ Mehal","year":"2006","unstructured":"Mehal WZ (2006) Activation-induced cell death of hepatic stellate cells by the innate immune system. Gastroenterology 130:600\u2013603","journal-title":"Gastroenterology"},{"key":"8323_CR21","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/hep.22813","volume":"49","author":"O Park","year":"2009","unstructured":"Park O, Jeong W-IL, Wang L et al (2009) Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride. Hepatology 49:1683\u20131694","journal-title":"Hepatology"},{"key":"8323_CR22","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nm1663","volume":"13","author":"E Seki","year":"2007","unstructured":"Seki E, De Minicis S, Osterreicher CH et al (2007) TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med 13:1324\u20131332","journal-title":"Nat Med"},{"key":"8323_CR23","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1872-034X.2011.00822.x","volume":"41","author":"E Seki","year":"2011","unstructured":"Seki E, Park E, Fujimoto J (2011) Toll-like receptor signaling in liver regeneration, fibrosis and carcinogenesis. Hepatol Res 41:597\u2013610","journal-title":"Hepatol Res"},{"key":"8323_CR24","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.1073\/pnas.82.24.8681","volume":"82","author":"SL Friedman","year":"1985","unstructured":"Friedman SL, Roll FJ, Boyles J, Bissell DM (1985) Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. Proc Natl Acad Sci USA 82:8681\u20138685","journal-title":"Proc Natl Acad Sci USA"},{"key":"8323_CR25","first-page":"509","volume":"132","author":"DA Otto","year":"1980","unstructured":"Otto DA, Veech RL (1980) Isolation of a lipocyte-rich fraction from rat liver nonparenchymal cells. Adv Exp Med Biol 132:509\u2013517","journal-title":"Adv Exp Med Biol"},{"key":"8323_CR26","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1172\/JCI113618","volume":"82","author":"JJ Maher","year":"1988","unstructured":"Maher JJ, Bissell DM, Friedman SL, Roll FJ (1988) Collagen measured in primary cultures of normal rat hepatocytes derives from lipocytes within the monolayer. J Clin Invest 82:450\u2013459","journal-title":"J Clin Invest"},{"key":"8323_CR27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0016-5085(90)91307-R","volume":"98","author":"S Milani","year":"1990","unstructured":"Milani S, Herbst H, Schuppan D, Kim KY, Riecken EO, Stein H (1990) Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis. Gastroenterology 98:175\u2013184","journal-title":"Gastroenterology"},{"key":"8323_CR28","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/S0168-8278(99)80328-6","volume":"31","author":"F Marra","year":"1999","unstructured":"Marra F (1999) Hepatic stellate cells and the regulation of liver inflammation. J Hepatol 31:1120\u20131130","journal-title":"J Hepatol"},{"key":"8323_CR29","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1055\/s-2001-17557","volume":"21","author":"JP Iredale","year":"2001","unstructured":"Iredale JP (2001) Hepatic stellate cell behavior during resolution of liver injury. Semin Liver Dis 21:427\u2013436","journal-title":"Semin Liver Dis"},{"key":"8323_CR30","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1055\/s-2001-17550","volume":"21","author":"A Geerts","year":"2001","unstructured":"Geerts A (2001) History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells. Semin Liver Dis 21:311\u2013335","journal-title":"Semin Liver Dis"},{"key":"8323_CR31","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1055\/s-2001-17551","volume":"21","author":"DC Rockey","year":"2001","unstructured":"Rockey DC (2001) Hepatic blood flow regulation by stellate cells in normal and injured liver. Semin Liver Dis 21:337\u2013349","journal-title":"Semin Liver Dis"},{"key":"8323_CR32","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1053\/jhep.2003.50068","volume":"37","author":"E Olaso","year":"2003","unstructured":"Olaso E, Salado C, Egilegor E et al (2003) Proangiogenic role of tumor-activated hepatic stellate cells in experimental melanoma metastasis. Hepatology 37:674\u2013685","journal-title":"Hepatology"},{"key":"8323_CR33","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1074\/jbc.275.4.2247","volume":"275","author":"SL Friedman","year":"2000","unstructured":"Friedman SL (2000) Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 275:2247\u20132250","journal-title":"J Biol Chem"},{"key":"8323_CR34","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0016-5085(00)70368-4","volume":"118","author":"R Bataller","year":"2000","unstructured":"Bataller R, Gines P, Nicolas JM et al (2000) Angiotensin II induces contraction and proliferation of human hepatic stellate cells. Gastroenterology 118:1149\u20131156","journal-title":"Gastroenterology"},{"key":"8323_CR35","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S1089-3261(05)70195-1","volume":"5","author":"DC Rockey","year":"2001","unstructured":"Rockey DC (2001) Cellular pathophysiology of portal hypertension and prospects for management with gene therapy. Clin Liver Dis 5:851\u2013865","journal-title":"Clin Liver Dis"},{"key":"8323_CR36","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","volume":"6","author":"V Hernandez-Gea","year":"2011","unstructured":"Hernandez-Gea V, Friedman SL (2011) Pathogenesis of liver fibrosis. Annu Rev Pathol 6:425\u2013456","journal-title":"Annu Rev Pathol"},{"key":"8323_CR37","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1172\/JCI200522675","volume":"115","author":"JS Duffield","year":"2005","unstructured":"Duffield JS, Forbes SJ, Constandinou CM et al (2005) Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest 115:56\u201365","journal-title":"J Clin Invest"},{"key":"8323_CR38","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1053\/j.gastro.2004.10.005","volume":"128","author":"M Imamura","year":"2005","unstructured":"Imamura M, Ogawa T, Sasaguri Y, Chayama K, Ueno H (2005) Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats. Gastroenterology 128:138\u2013146","journal-title":"Gastroenterology"},{"key":"8323_CR39","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/hep.1840110412","volume":"11","author":"M Matsuoka","year":"1990","unstructured":"Matsuoka M, Tsukamoto H (1990) Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor beta: implication for a pathogenetic role in alcoholic liver fibrogenesis. Hepatology 11:599\u2013605","journal-title":"Hepatology"},{"key":"8323_CR40","doi-asserted-by":"crossref","first-page":"d1720","DOI":"10.2741\/pinzani","volume":"7","author":"M Pinzani","year":"2002","unstructured":"Pinzani M (2002) PDGF and signal transduction in hepatic stellate cells. Front Biosci 7:d1720\u2013d1726","journal-title":"Front Biosci"},{"key":"8323_CR41","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1053\/jhep.2001.28457","volume":"34","author":"DM Bissell","year":"2001","unstructured":"Bissell DM, Roulot D, George J (2001) Transforming growth factor beta and the liver. Hepatology 34:859\u2013867","journal-title":"Hepatology"},{"key":"8323_CR42","first-page":"307","volume":"23","author":"AM Tiggelman","year":"1995","unstructured":"Tiggelman AM, Boers W, Linthorst C, Sala M, Chamuleau RA (1995) Collagen synthesis by human liver (myo)fibroblasts in culture: evidence for a regulatory role of IL-1 beta, IL-4, TGF beta and IFN gamma. J Hepatol 23:307\u2013317","journal-title":"J Hepatol"},{"key":"8323_CR43","doi-asserted-by":"crossref","first-page":"10663","DOI":"10.1073\/pnas.94.20.10663","volume":"94","author":"Z Shi","year":"1997","unstructured":"Shi Z, Wakil AE, Rockey DC (1997) Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses. Proc Natl Acad Sci USA 94:10663\u201310668","journal-title":"Proc Natl Acad Sci USA"},{"key":"8323_CR44","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/376594a0","volume":"376","author":"TA Wynn","year":"1995","unstructured":"Wynn TA, Cheever AW, Jankovic D et al (1995) An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection. Nature 376:594\u2013596","journal-title":"Nature"},{"key":"8323_CR45","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1172\/JCI112945","volume":"79","author":"RD Granstein","year":"1987","unstructured":"Granstein RD, Murphy GF, Margolis RJ, Byrne MH, Amento EP (1987) Gamma-interferon inhibits collagen synthesis in vivo in the mouse. J Clin Invest 79:1254\u20131258","journal-title":"J Clin Invest"},{"key":"8323_CR46","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1053\/j.gastro.2011.08.008","volume":"141","author":"MM Mentink-Kane","year":"2011","unstructured":"Mentink-Kane MM, Cheever AW, Wilson MS et al (2011) Accelerated and progressive and lethal liver fibrosis in mice that lack interleukin (IL)-10, IL-12p40, and IL-13R\u03b12. Gastroenterology 141:2200\u20132209","journal-title":"Gastroenterology"},{"key":"8323_CR47","doi-asserted-by":"crossref","first-page":"6406","DOI":"10.4049\/jimmunol.164.12.6406","volume":"164","author":"KF Hoffmann","year":"2000","unstructured":"Hoffmann KF, Cheever AW, Wynn TA (2000) IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis. J Immunol 164:6406\u20136416","journal-title":"J Immunol"},{"key":"8323_CR48","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1084\/jem.20061308","volume":"203","author":"SC Liang","year":"2006","unstructured":"Liang SC, Tan XY, Luxenberg DP et al (2006) Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 203:2271\u20132279","journal-title":"J Exp Med"},{"key":"8323_CR49","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jaut.2008.11.001","volume":"32","author":"RY Lan","year":"2009","unstructured":"Lan RY, Salunga TL, Tsuneyama K et al (2009) Hepatic IL-17 responses in human and murine primary biliary cirrhosis. J Autoimmun 32:43\u201351","journal-title":"J Autoimmun"},{"key":"8323_CR50","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/ni.1770","volume":"10","author":"S Trifari","year":"2009","unstructured":"Trifari S, Kaplan CD, Tran EH, Crellin NK, Spits H (2009) Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells. Nat Immunol 10:864\u2013871","journal-title":"Nat Immunol"},{"key":"8323_CR51","first-page":"3573","volume":"119","author":"S Eyerich","year":"2009","unstructured":"Eyerich S, Eyerich K, Pennino D et al (2009) Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest 119:3573\u20133585","journal-title":"J Clin Invest"},{"key":"8323_CR52","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00281-009-0188-x","volume":"32","author":"K Wolk","year":"2010","unstructured":"Wolk K, Witte E, Witte K, Warszawska K, Sabat R (2010) Biology of interleukin-22. Semin Immunopathol 32:17\u201331","journal-title":"Semin Immunopathol"},{"key":"8323_CR53","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00109-009-0448-1","volume":"87","author":"SJ Aujla","year":"2009","unstructured":"Aujla SJ, Kolls JK (2009) IL-22: a critical mediator in mucosal host defense. J Mol Med (Berl) 87:451\u2013454","journal-title":"J Mol Med (Berl)"},{"key":"8323_CR54","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/hep.20184","volume":"39","author":"S Radaeva","year":"2004","unstructured":"Radaeva S, Sun R, Pan HN, Hong F, Gao B (2004) Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 39:1332\u20131342","journal-title":"Hepatology"},{"key":"8323_CR55","first-page":"43","volume":"1","author":"H Pan","year":"2004","unstructured":"Pan H, Hong F, Radaeva S, Gao B (2004) Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3. Cell Mol Immunol 1:43\u201349","journal-title":"Cell Mol Immunol"},{"key":"8323_CR56","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.immuni.2007.07.023","volume":"27","author":"LA Zenewicz","year":"2007","unstructured":"Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Karow M, Flavell RA (2007) Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 27:647\u2013659","journal-title":"Immunity"},{"key":"8323_CR57","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/hep.23837","volume":"52","author":"SH Ki","year":"2010","unstructured":"Ki SH, Park O, Zheng M et al (2010) Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3. Hepatology 52:1291\u20131300","journal-title":"Hepatology"},{"key":"8323_CR58","doi-asserted-by":"crossref","unstructured":"Xiang X, Gui H, King NJ et al (2011) IL-22 and non-ELR-CXC chemokine expression in chronic hepatitis B virus-infected liver. Immunol Cell Biol. doi: 10.1038\/icb.2011.79","DOI":"10.1038\/icb.2011.79"},{"key":"8323_CR59","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1189\/JLB.0309135","volume":"86","author":"B Gao","year":"2009","unstructured":"Gao B, Radaeva S, Park O (2009) Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases. J Leukoc Biol 86:513\u2013528","journal-title":"J Leukoc Biol"},{"key":"8323_CR60","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.1073\/pnas.040566697","volume":"97","author":"K Takeda","year":"2000","unstructured":"Takeda K, Hayakawa Y, Van Kaer L, Matsuda H, Yagita H, Okumura K (2000) Critical contribution of liver natural killer T cells to a murine model of hepatitis. Proc Natl Acad Sci USA 97:5498\u20135503","journal-title":"Proc Natl Acad Sci USA"},{"key":"8323_CR61","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1002\/hep.21597","volume":"45","author":"Z Dong","year":"2007","unstructured":"Dong Z, Zhang J, Sun R, Wei H, Tian Z (2007) Impairment of liver regeneration correlates with activated hepatic NKT cells in HBV transgenic mice. Hepatology 45:1400\u20131412","journal-title":"Hepatology"},{"key":"8323_CR62","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1053\/jhep.2003.50471","volume":"38","author":"H Ito","year":"2003","unstructured":"Ito H, Ando K, Nakayama T et al (2003) Role of Valpha 14 NKT cells in the development of impaired liver regeneration in vivo. Hepatology 38:1116\u20131124","journal-title":"Hepatology"},{"key":"8323_CR63","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1053\/j.gastro.2006.08.028","volume":"131","author":"H Nakashima","year":"2006","unstructured":"Nakashima H, Inui T, Habu Y et al (2006) Activation of mouse natural killer T cells accelerates liver regeneration after partial hepatectomy. Gastroenterology 131:1573\u20131583","journal-title":"Gastroenterology"},{"key":"8323_CR64","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/hep.21174","volume":"43","author":"B Li","year":"2006","unstructured":"Li B, Sun R, Wei H, Gao B, Tian Z (2006) Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism. Hepatology 43:1211\u20131219","journal-title":"Hepatology"},{"key":"8323_CR65","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1053\/jhep.2003.50002","volume":"37","author":"P Taimr","year":"2003","unstructured":"Taimr P, Higuchi H, Kocova E, Rippe RA, Friedman S, Gores GJ (2003) Activated stellate cells express the TRAIL receptor-2\/death receptor-5 and undergo TRAIL-mediated apoptosis. Hepatology 37:87\u201395","journal-title":"Hepatology"},{"key":"8323_CR66","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/hep.21419","volume":"44","author":"WI Jeong","year":"2006","unstructured":"Jeong WI, Park O, Radaeva S, Gao B (2006) STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity. Hepatology 44:1441\u20131451","journal-title":"Hepatology"},{"key":"8323_CR67","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1586\/17474124.1.1.173","volume":"1","author":"B Gao","year":"2007","unstructured":"Gao B, Radaeva S, Jeong W-I (2007) Activation of natural killer cells inhibits liver fibrosis: a novel strategy to treat liver fibrosis. Expert Rev Gastroenterol Hepatol 1:173\u2013180","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"8323_CR68","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cell.2008.06.049","volume":"134","author":"V Krizhanovsky","year":"2008","unstructured":"Krizhanovsky V, Yon M, Dickins RA et al (2008) Senescence of activated stellate cells limits liver fibrosis. Cell 134:657\u2013667","journal-title":"Cell"},{"key":"8323_CR69","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1002\/hep.510250508","volume":"25","author":"FJ Laso","year":"1997","unstructured":"Laso FJ, Madruga JI, Giron JA et al (1997) Decreased natural killer cytotoxic activity in chronic alcoholism is associated with alcohol liver disease but not active ethanol consumption. Hepatology 25:1096\u20131100","journal-title":"Hepatology"},{"key":"8323_CR70","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1111\/j.1530-0277.2006.00194.x","volume":"30","author":"HN Pan","year":"2006","unstructured":"Pan HN, Sun R, Jaruga B, Hong F, Kim WH, Gao B (2006) Chronic ethanol consumption inhibits hepatic natural killer cell activity and accelerates murine cytomegalovirus-induced hepatitis. Alcohol Clin Exp Res 30:1615\u20131623","journal-title":"Alcohol Clin Exp Res"},{"key":"8323_CR71","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1530-0277.2008.00842.x","volume":"33","author":"G Szabo","year":"2009","unstructured":"Szabo G, Mandrekar P (2009) A recent perspective on alcohol, immunity, and host defense. Alcohol Clin Exp Res 33:220\u2013232","journal-title":"Alcohol Clin Exp Res"},{"key":"8323_CR72","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1053\/j.gastro.2007.11.061","volume":"134","author":"GE Arteel","year":"2008","unstructured":"Arteel GE (2008) Silencing a killer among us: ethanol impairs immune surveillance of activated stellate cells by natural killer cells. Gastroenterology 134:351\u2013353","journal-title":"Gastroenterology"},{"key":"8323_CR73","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1053\/j.gastro.2007.09.034","volume":"134","author":"WI Jeong","year":"2008","unstructured":"Jeong WI, Park O, Gao B (2008) Abrogation of the antifibrotic effects of natural killer cells\/interferon-gamma contributes to alcohol acceleration of liver fibrosis. Gastroenterology 134:248\u2013258","journal-title":"Gastroenterology"},{"key":"8323_CR74","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1136\/gut.2005.076463","volume":"55","author":"J Nattermann","year":"2006","unstructured":"Nattermann J, Feldmann G, Ahlenstiel G, Langhans B, Sauerbruch T, Spengler U (2006) Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C. Gut 55:869\u2013877","journal-title":"Gut"},{"key":"8323_CR75","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.4049\/jimmunol.173.10.6072","volume":"173","author":"M Jinushi","year":"2004","unstructured":"Jinushi M, Takehara T, Tatsumi T et al (2004) Negative regulation of NK cell activities by inhibitory receptor CD94\/NKG2A leads to altered NK cell-induced modulation of dendritic cell functions in chronic hepatitis C virus infection. J Immunol 173:6072\u20136081","journal-title":"J Immunol"},{"key":"8323_CR76","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/hep.21073","volume":"43","author":"C Morishima","year":"2006","unstructured":"Morishima C, Paschal DM, Wang CC et al (2006) Decreased NK cell frequency in chronic hepatitis C does not affect ex vivo cytolytic killing. Hepatology 43:573\u2013580","journal-title":"Hepatology"},{"key":"8323_CR77","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1872-034X.2008.00317.x","volume":"38","author":"S Yamagiwa","year":"2008","unstructured":"Yamagiwa S, Matsuda Y, Ichida T et al (2008) Sustained response to interferon-alpha plus ribavirin therapy for chronic hepatitis C is closely associated with increased dynamism of intrahepatic natural killer and natural killer T cells. Hepatol Res 38:664\u2013672","journal-title":"Hepatol Res"},{"key":"8323_CR78","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1136\/gut.2007.130963","volume":"57","author":"L Golden-Mason","year":"2008","unstructured":"Golden-Mason L, Madrigal-Estebas L, McGrath E et al (2008) Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure. Gut 57:1121\u20131128","journal-title":"Gut"},{"key":"8323_CR79","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1053\/jhep.2000.19362","volume":"32","author":"N Kawarabayashi","year":"2000","unstructured":"Kawarabayashi N, Seki S, Hatsuse K et al (2000) Decrease of CD56(+)T cells and natural killer cells in cirrhotic livers with hepatitis C may be involved in their susceptibility to hepatocellular carcinoma. Hepatology 32:962\u2013969","journal-title":"Hepatology"},{"key":"8323_CR80","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1053\/j.gastro.2004.01.022","volume":"126","author":"M Minagawa","year":"2004","unstructured":"Minagawa M, Deng Q, Liu ZX, Tsukamoto H, Dennert G (2004) Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption. Gastroenterology 126:1387\u20131399","journal-title":"Gastroenterology"},{"key":"8323_CR81","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.4049\/jimmunol.173.2.1417","volume":"173","author":"C Lalla de","year":"2004","unstructured":"de Lalla C, Galli G, Aldrighetti L et al (2004) Production of profibrotic cytokines by invariant NKT cells characterizes cirrhosis progression in chronic viral hepatitis. J Immunol 173:1417\u20131425","journal-title":"J Immunol"},{"key":"8323_CR82","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1053\/j.gastro.2006.01.038","volume":"130","author":"RF Schwabe","year":"2006","unstructured":"Schwabe RF, Seki E, Brenner DA (2006) Toll-like receptor signaling in the liver. Gastroenterology 130:1886\u20131900","journal-title":"Gastroenterology"},{"key":"8323_CR83","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.4049\/jimmunol.166.4.2651","volume":"166","author":"E Seki","year":"2001","unstructured":"Seki E, Tsutsui H, Nakano H et al (2001) Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta. J Immunol 166:2651\u20132657","journal-title":"J Immunol"},{"key":"8323_CR84","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1055\/s-0030-1255353","volume":"30","author":"JP Pradere","year":"2010","unstructured":"Pradere JP, Troeger JS, Dapito DH, Mencin AA, Schwabe RF (2010) Toll-like receptor 4 and hepatic fibrogenesis. Semin Liver Dis 30:232\u2013244","journal-title":"Semin Liver Dis"},{"key":"8323_CR85","doi-asserted-by":"crossref","first-page":"G1318","DOI":"10.1152\/ajpgi.00405.2005","volume":"290","author":"F Isayama","year":"2006","unstructured":"Isayama F, Hines IN, Kremer M et al (2006) LPS signaling enhances hepatic fibrogenesis caused by experimental cholestasis in mice. Am J Physiol Gastrointest Liver Physiol 290:G1318\u2013G1328","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"8323_CR86","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/hep.22034","volume":"47","author":"B Gao","year":"2008","unstructured":"Gao B, Jeong WI, Tian Z (2008) Liver: an organ with predominant innate immunity. Hepatology 47:729\u2013736","journal-title":"Hepatology"},{"key":"8323_CR87","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1053\/jhep.2003.50182","volume":"37","author":"YH Paik","year":"2003","unstructured":"Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C, Brenner DA (2003) Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology 37:1043\u20131055","journal-title":"Hepatology"},{"key":"8323_CR88","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1002\/hep.21867","volume":"46","author":"A Watanabe","year":"2007","unstructured":"Watanabe A, Hashmi A, Gomes DA et al (2007) Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9. Hepatology 46:1509\u20131518","journal-title":"Hepatology"},{"key":"8323_CR89","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bbrc.2008.08.096","volume":"376","author":"E Gabele","year":"2008","unstructured":"Gabele E, Muhlbauer M, Dorn C et al (2008) Role of TLR9 in hepatic stellate cells and experimental liver fibrosis. Biochem Biophys Res Com 376:271\u2013276","journal-title":"Biochem Biophys Res Com"},{"key":"8323_CR90","first-page":"3213","volume":"119","author":"MK Connolly","year":"2009","unstructured":"Connolly MK, Bedrosian AS, Mallen-St Clair J et al (2009) In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha. J Clin Invest 119:3213\u20133225","journal-title":"J Clin Invest"},{"key":"8323_CR91","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","volume":"140","author":"O Takeuchi","year":"2010","unstructured":"Takeuchi O, Akira S (2010) Pattern recognition receptors and inflammation. Cell 140:805\u2013820","journal-title":"Cell"},{"key":"8323_CR92","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1002\/hep.24190","volume":"53","author":"WI Jeong","year":"2011","unstructured":"Jeong WI, Park O, Suh YG et al (2011) Suppression of innate immunity (natural killer cell\/interferon-gamma) in the advanced stages of liver fibrosis in mice. Hepatology 53:1342\u20131351","journal-title":"Hepatology"},{"key":"8323_CR93","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0016-5085(81)80001-7","volume":"81","author":"RG Lee","year":"1981","unstructured":"Lee RG, Epstein O, Jauregui H, Sherlock S, Scheuer PJ (1981) Granulomas in primary biliary cirrhosis: a prognostic feature. Gastroenterology 81:983\u2013986","journal-title":"Gastroenterology"},{"key":"8323_CR94","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0168-8278(02)00413-0","volume":"38","author":"T Poynard","year":"2003","unstructured":"Poynard T (2003) A comparison of fibrosis progression in chronic liver diseases. J Hepatol 38:257\u2013265","journal-title":"J Hepatol"},{"key":"8323_CR95","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00432479","volume":"379","author":"J Ludwig","year":"1978","unstructured":"Ludwig J, Dickson ER, McDonald GS (1978) Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis). Virchows Arch A Pathol Anat Histol 379:103\u2013112","journal-title":"Virchows Arch A Pathol Anat Histol"},{"key":"8323_CR96","first-page":"1257","volume":"60","author":"P Scheuer","year":"1967","unstructured":"Scheuer P (1967) Primary biliary cirrhosis. Proc R Soc Med 60:1257\u20131260","journal-title":"Proc R Soc Med"},{"key":"8323_CR97","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1084\/jem.181.5.1835","volume":"181","author":"S Shimoda","year":"1995","unstructured":"Shimoda S, Nakamura M, Ishibashi H, Hayashida K, Niho Y (1995) HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases. J Exp Med 181:1835\u20131845","journal-title":"J Exp Med"},{"key":"8323_CR98","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/hep.510250402","volume":"25","author":"K Harada","year":"1997","unstructured":"Harada K, Van de Water J, Leung PS et al (1997) In situ nucleic acid hybridization of cytokines in primary biliary cirrhosis: predominance of the Th1 subset. Hepatology 25:791\u2013796","journal-title":"Hepatology"},{"key":"8323_CR99","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/hep.510280303","volume":"28","author":"K Tsuneyama","year":"1998","unstructured":"Tsuneyama K, Yasoshima M, Harada K, Hiramatsu K, Gershwin ME, Nakanuma Y (1998) Increased CD1d expression on small bile duct epithelium and epithelioid granuloma in livers in primary biliary cirrhosis. Hepatology 28:620\u2013623","journal-title":"Hepatology"},{"key":"8323_CR100","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1053\/gast.2002.36020","volume":"123","author":"H Kita","year":"2002","unstructured":"Kita H, Naidenko OV, Kronenberg M et al (2002) Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human CD1d tetramer. Gastroenterology 123:1031\u20131043","journal-title":"Gastroenterology"},{"key":"8323_CR101","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1053\/j.gastro.2004.11.005","volume":"128","author":"K Kikuchi","year":"2005","unstructured":"Kikuchi K, Lian ZX, Yang GX et al (2005) Bacterial CpG induces hyper-IgM production in CD27(+) memory B cells in primary biliary cirrhosis. Gastroenterology 128:304\u2013312","journal-title":"Gastroenterology"},{"key":"8323_CR102","doi-asserted-by":"crossref","first-page":"5874","DOI":"10.4049\/jimmunol.174.9.5874","volume":"174","author":"K Amano","year":"2005","unstructured":"Amano K, Leung PS, Rieger R et al (2005) Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid. J Immunol 174:5874\u20135883","journal-title":"J Immunol"},{"key":"8323_CR103","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/hep.20859","volume":"42","author":"TK Mao","year":"2005","unstructured":"Mao TK, Lian ZX, Selmi C et al (2005) Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis. Hepatology 42:802\u2013808","journal-title":"Hepatology"},{"key":"8323_CR104","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jaut.2006.04.001","volume":"26","author":"YH Chuang","year":"2006","unstructured":"Chuang YH, Lian ZX, Tsuneyama K et al (2006) Increased killing activity and decreased cytokine production in NK cells in patients with primary biliary cirrhosis. J Autoimmun 26:232\u2013240","journal-title":"J Autoimmun"},{"key":"8323_CR105","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/hep.21123","volume":"43","author":"RY Lan","year":"2006","unstructured":"Lan RY, Cheng C, Lian ZX et al (2006) Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis. Hepatology 43:729\u2013737","journal-title":"Hepatology"},{"key":"8323_CR106","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/hep.21522","volume":"45","author":"Y Moritoki","year":"2007","unstructured":"Moritoki Y, Lian ZX, Wulff H et al (2007) AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers. Hepatology 45:314\u2013322","journal-title":"Hepatology"},{"key":"8323_CR107","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/hep.23783","volume":"52","author":"A Lleo","year":"2010","unstructured":"Lleo A, Bowlus CL, Yang GX et al (2010) Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis. Hepatology 52:987\u2013998","journal-title":"Hepatology"},{"key":"8323_CR108","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/hep.24194","volume":"53","author":"S Shimoda","year":"2011","unstructured":"Shimoda S, Harada K, Niiro H et al (2011) Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis. Hepatology 53:1270\u20131281","journal-title":"Hepatology"},{"key":"8323_CR109","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/hep.24526","volume":"54","author":"M Tsuda","year":"2011","unstructured":"Tsuda M, Ambrosini YM, Zhang W et al (2011) Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive T cells in human patients with primary biliary cirrhosis. Hepatology 54:1293\u20131302","journal-title":"Hepatology"},{"key":"8323_CR110","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1365-2249.2008.03837.x","volume":"155","author":"K Wakabayashi","year":"2009","unstructured":"Wakabayashi K, Yoshida K, Leung PS et al (2009) Induction of autoimmune cholangitis in non-obese diabetic (NOD).1101 mice following a chemical xenobiotic immunization. Clin Exp Immunol 155:577\u2013586","journal-title":"Clin Exp Immunol"},{"key":"8323_CR111","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cellimm.2011.01.005","volume":"268","author":"Y Moritoki","year":"2011","unstructured":"Moritoki Y, Tsuda M, Tsuneyama K et al (2011) B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD.c3c4 model of autoimmune cholangitis. Cell Immunol 268:16\u201323","journal-title":"Cell Immunol"},{"key":"8323_CR112","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1365-2249.2011.04453.x","volume":"166","author":"YM Ambrosini","year":"2011","unstructured":"Ambrosini YM, Yang GX, Zhang W et al (2011) The multi-hit hypothesis of primary biliary cirrhosis: polyinosinic-polycytidylic acid (poly I:C) and murine autoimmune cholangitis. Clin Exp Immunol 166:110\u2013120","journal-title":"Clin Exp Immunol"},{"key":"8323_CR113","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/hep.24113","volume":"53","author":"SJ Wu","year":"2011","unstructured":"Wu SJ, Yang YH, Tsuneyama K et al (2011) Innate immunity and primary biliary cirrhosis: activated invariant natural killer T cells exacerbate murine autoimmune cholangitis and fibrosis. Hepatology 53:915\u2013925","journal-title":"Hepatology"},{"key":"8323_CR114","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/hep.24044","volume":"53","author":"A Dhirapong","year":"2011","unstructured":"Dhirapong A, Lleo A, Yang GX et al (2011) B cell depletion therapy exacerbates murine primary biliary cirrhosis. Hepatology 53:527\u2013535","journal-title":"Hepatology"},{"key":"8323_CR115","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.4049\/jimmunol.1001597","volume":"186","author":"GX Yang","year":"2011","unstructured":"Yang GX, Wu Y, Tsukamoto H et al (2011) CD8 T cells mediate direct biliary ductule damage in nonobese diabetic autoimmune biliary disease. J Immunol 186:1259\u20131267","journal-title":"J Immunol"},{"key":"8323_CR116","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.4049\/jimmunol.177.3.1655","volume":"177","author":"S Oertelt","year":"2006","unstructured":"Oertelt S, Lian ZX, Cheng CM et al (2006) Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice. J Immunol 177:1655\u20131660","journal-title":"J Immunol"},{"key":"8323_CR117","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/hep.22052","volume":"47","author":"YH Chuang","year":"2008","unstructured":"Chuang YH, Lian ZX, Yang GX et al (2008) Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis. Hepatology 47:571\u2013580","journal-title":"Hepatology"},{"key":"8323_CR118","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1002\/hep.22226","volume":"47","author":"GX Yang","year":"2008","unstructured":"Yang GX, Lian ZX, Chuang YH et al (2008) Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice. Hepatology 47:1974\u20131982","journal-title":"Hepatology"},{"key":"8323_CR119","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1002\/hep.23132","volume":"50","author":"K Yoshida","year":"2009","unstructured":"Yoshida K, Yang GX, Zhang W et al (2009) Deletion of interleukin-12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor beta receptor type II mice. Hepatology 50:1494\u20131500","journal-title":"Hepatology"},{"key":"8323_CR120","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1053\/j.gastro.2008.11.035","volume":"136","author":"Y Moritoki","year":"2009","unstructured":"Moritoki Y, Zhang W, Tsuneyama K et al (2009) B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis. Gastroenterology 136:1037\u20131047","journal-title":"Gastroenterology"},{"key":"8323_CR121","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/hep.23664","volume":"52","author":"W Zhang","year":"2010","unstructured":"Zhang W, Tsuda M, Yang GX et al (2010) Deletion of interleukin-6 in mice with the dominant negative form of transforming growth factor beta receptor II improves colitis but exacerbates autoimmune cholangitis. Hepatology 52:215\u2013222","journal-title":"Hepatology"},{"key":"8323_CR122","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1111\/j.1572-0241.1999.01547.x","volume":"94","author":"H Sekiya","year":"1999","unstructured":"Sekiya H, Komatsu T, Isono E et al (1999) Decrease in the prevalence of IL-4-producing CD4+ T cells in patients with advanced stage of primary biliary cirrhosis. Am J Gastroenterol 94:3589\u20133594","journal-title":"Am J Gastroenterol"},{"key":"8323_CR123","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.chom.2008.03.009","volume":"3","author":"J Mattner","year":"2008","unstructured":"Mattner J, Savage PB, Leung P et al (2008) Liver autoimmunity triggered by microbial activation of natural killer T cells. Cell Host Microbe 3:304\u2013315","journal-title":"Cell Host Microbe"},{"key":"8323_CR124","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nature06306","volume":"450","author":"LW Collison","year":"2007","unstructured":"Collison LW, Workman CJ, Kuo TT et al (2007) The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 450:566\u2013569","journal-title":"Nature"},{"key":"8323_CR125","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1600-065X.2008.00704.x","volume":"226","author":"LW Collison","year":"2008","unstructured":"Collison LW, Vignali DA (2008) Interleukin-35: odd one out or part of the family? Immunol Rev 226:248\u2013262","journal-title":"Immunol Rev"},{"key":"8323_CR126","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev.iy.13.040195.001343","volume":"13","author":"G Trinchieri","year":"1995","unstructured":"Trinchieri G (1995) Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 13:251\u2013276","journal-title":"Annu Rev Immunol"},{"key":"8323_CR127","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S1074-7613(00)00070-4","volume":"13","author":"B Oppmann","year":"2000","unstructured":"Oppmann B, Lesley R, Blom B et al (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13:715\u2013725","journal-title":"Immunity"},{"key":"8323_CR128","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/eji.1830250133","volume":"25","author":"S Gillessen","year":"1995","unstructured":"Gillessen S, Carvajal D, Ling P et al (1995) Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur J Immunol 25:200\u2013206","journal-title":"Eur J Immunol"},{"key":"8323_CR129","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/tropej\/fmm119","volume":"54","author":"AS Pulickal","year":"2008","unstructured":"Pulickal AS, Hambleton S, Callaghan MJ et al (2008) Biliary cirrhosis in a child with inherited interleukin-12 deficiency. J Trop Pediatr 54:269\u2013271","journal-title":"J Trop Pediatr"},{"key":"8323_CR130","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1056\/NEJMoa0810440","volume":"360","author":"GM Hirschfield","year":"2009","unstructured":"Hirschfield GM, Liu X, Xu C et al (2009) Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. N Engl J Med 360:2544\u20132555","journal-title":"N Engl J Med"},{"key":"8323_CR131","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1365-2249.2009.03898.x","volume":"156","author":"G Rong","year":"2009","unstructured":"Rong G, Zhou Y, Xiong Y et al (2009) Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: the serum cytokine profile and peripheral cell population. Clin Exp Immunol 156:217\u2013225","journal-title":"Clin Exp Immunol"},{"key":"8323_CR132","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1365-2249.2009.03947.x","volume":"157","author":"K Harada","year":"2009","unstructured":"Harada K, Shimoda S, Sato Y, Isse K, Ikeda H, Nakanuma Y (2009) Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis. Clin Exp Immunol 157:261\u2013270","journal-title":"Clin Exp Immunol"},{"key":"8323_CR133","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/345803","volume":"2011","author":"L Hammerich","year":"2011","unstructured":"Hammerich L, Heymann F, Tacke F (2011) Role of IL-17 and Th17 cells in liver diseases. Clin Dev Immunol 2011:1\u201312","journal-title":"Clin Dev Immunol"},{"key":"8323_CR134","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1034\/j.1600-0676.2003.00807.x","volume":"23","author":"K Harada","year":"2003","unstructured":"Harada K, Isse K, Tsuneyama K, Ohta H, Nakanuma Y (2003) Accumulating CD57 + CD3 + natural killer T cells are related to intrahepatic bile duct lesions in primary biliary cirrhosis. Liver Int 23:94\u2013100","journal-title":"Liver Int"},{"key":"8323_CR135","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/labinvest.3700285","volume":"85","author":"Y Takii","year":"2005","unstructured":"Takii Y, Nakamura M, Ito M et al (2005) Enhanced expression of type I interferon and toll-like receptor-3 in primary biliary cirrhosis. Lab Invest 85:908\u2013920","journal-title":"Lab Invest"},{"key":"8323_CR136","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.biocel.2006.10.006","volume":"39","author":"AK Muddu","year":"2007","unstructured":"Muddu AK, Guha IN, Elsharkawy AM, Mann DA (2007) Resolving fibrosis in the diseased liver: translating the scientific promise to the clinic. Int J Biochem Cell Biol 39:695\u2013714","journal-title":"Int J Biochem Cell Biol"}],"container-title":["Clinical Reviews in Allergy & Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-012-8323-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12016-012-8323-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-012-8323-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T02:12:35Z","timestamp":1594260755000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12016-012-8323-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,14]]},"references-count":136,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["8323"],"URL":"https:\/\/doi.org\/10.1007\/s12016-012-8323-1","relation":{},"ISSN":["1080-0549","1559-0267"],"issn-type":[{"value":"1080-0549","type":"print"},{"value":"1559-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,14]]}}}