{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:25:06Z","timestamp":1792545906707,"version":"4.5.0"},"reference-count":497,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T00:00:00Z","timestamp":1365724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T00:00:00Z","timestamp":1365724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clinic Rev Allerg Immunol"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1007\/s12016-013-8368-9","type":"journal-article","created":{"date-parts":[[2013,4,11]],"date-time":"2013-04-11T01:56:25Z","timestamp":1365645385000},"page":"331-379","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":602,"title":["Respiratory Syncytial Virus\u2014A Comprehensive Review"],"prefix":"10.1007","volume":"45","author":[{"given":"Andrea T.","family":"Borchers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Eric","family":"Gershwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel J.","family":"Gershwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,4,12]]},"reference":[{"key":"8368_CR1","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3181\/00379727-92-22538","volume":"92","author":"RE Blount Jr","year":"1956","unstructured":"Blount RE Jr, Morris JA, Savage RE (1956) Recovery of cytopathogenic agent from chimpanzees with coryza. Proc Soc Exp Biol Med 92:544\u2013549","journal-title":"Proc Soc Exp Biol Med"},{"key":"8368_CR2","first-page":"281","volume":"66","author":"R Chanock","year":"1957","unstructured":"Chanock R, Roizman B, Myers R (1957) Recovery from infants with respiratory illness of a virus related to chimpanzee coryza agent (CCA). I. Isolation, properties and characterization. Am J Hyg 66:281\u2013290","journal-title":"Am J Hyg"},{"key":"8368_CR3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1086\/498526","volume":"193","author":"R Gilca","year":"2006","unstructured":"Gilca R, De Serres G, Tremblay M et al (2006) Distribution and clinical impact of human respiratory syncytial virus genotypes in hospitalized children over 2 winter seasons. J Infect Dis 193:54\u201358","journal-title":"J Infect Dis"},{"key":"8368_CR4","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/(SICI)1096-9071(200005)61:1<76::AID-JMV12>3.0.CO;2-P","volume":"61","author":"MS Imaz","year":"2000","unstructured":"Imaz MS, Sequeira MD, Videla C et al (2000) Clinical and epidemiologic characteristics of respiratory syncytial virus subgroups A and B infections in Santa Fe, Argentina. J Med Virol 61:76\u201380","journal-title":"J Med Virol"},{"key":"8368_CR5","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1136\/adc.77.6.508","volume":"77","author":"JN Fletcher","year":"1997","unstructured":"Fletcher JN, Smyth RL, Thomas HM, Ashby D, Hart CA (1997) Respiratory syncytial virus genotypes and disease severity among children in hospital. Arch Dis Child 77:508\u2013511","journal-title":"Arch Dis Child"},{"key":"8368_CR6","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1086\/315508","volume":"181","author":"TC Peret","year":"2000","unstructured":"Peret TC, Hall CB, Hammond GW et al (2000) Circulation patterns of group A and B human respiratory syncytial virus genotypes in 5 communities in North America. J Infect Dis 181:1891\u20131896","journal-title":"J Infect Dis"},{"key":"8368_CR7","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jpeds.2008.07.053","volume":"154","author":"LG Stensballe","year":"2009","unstructured":"Stensballe LG, Ravn H, Kristensen K, Meakins T, Aaby P, Simoes EA (2009) Seasonal variation of maternally derived respiratory syncytial virus antibodies and association with infant hospitalizations for respiratory syncytial virus. J Pediatr 154:296\u2013298","journal-title":"J Pediatr"},{"key":"8368_CR8","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0929-6646(11)60057-0","volume":"110","author":"H Chi","year":"2011","unstructured":"Chi H, Chang IS, Tsai FY et al (2011) Epidemiological study of hospitalization associated with respiratory syncytial virus infection in Taiwanese children between 2004 and 2007. J Formos Med Assoc 110:388\u2013396","journal-title":"J Formos Med Assoc"},{"key":"8368_CR9","first-page":"543","volume":"140","author":"WP Glezen","year":"1986","unstructured":"Glezen WP, Taber LH, Frank AL, Kasel JA (1986) Risk of primary infection and reinfection with respiratory syncytial virus. Am J Dis Child 140:543\u2013546","journal-title":"Am J Dis Child"},{"key":"8368_CR10","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1056\/NEJM197602192940803","volume":"294","author":"CB Hall","year":"1976","unstructured":"Hall CB, Geiman JM, Biggar R, Kotok DI, Hogan PM, Douglas GR Jr (1976) Respiratory syncytial virus infections within families. N Engl J Med 294:414\u2013419","journal-title":"N Engl J Med"},{"key":"8368_CR11","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1164\/rccm.200210-1148OC","volume":"168","author":"JP Legg","year":"2003","unstructured":"Legg JP, Hussain IR, Warner JA, Johnston SL, Warner JO (2003) Type 1 and type 2 cytokine imbalance in acute respiratory syncytial virus bronchiolitis. Am J Respir Crit Care Med 168:633\u2013639","journal-title":"Am J Respir Crit Care Med"},{"key":"8368_CR12","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/1743-422X-9-130","volume":"9","author":"P Sastre","year":"2012","unstructured":"Sastre P, Ruiz T, Schildgen O, Schildgen V, Vela C, Rueda P (2012) Seroprevalence of human respiratory syncytial virus and human metapneumovirus in healthy population analyzed by recombinant fusion protein-based enzyme linked immunosorbent assay. Virol J 9:130","journal-title":"Virol J"},{"key":"8368_CR13","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/jmv.10572","volume":"72","author":"T Ebihara","year":"2004","unstructured":"Ebihara T, Endo R, Kikuta H, Ishiguro N, Ishiko H, Kobayashi K (2004) Comparison of the seroprevalence of human metapneumovirus and human respiratory syncytial virus. J Med Virol 72:304\u2013306","journal-title":"J Med Virol"},{"key":"8368_CR14","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1056\/NEJM197903083001004","volume":"300","author":"FW Henderson","year":"1979","unstructured":"Henderson FW, Collier AM, Clyde WA Jr, Denny FW (1979) Respiratory-syncytial-virus infections, reinfections and immunity. A prospective, longitudinal study in young children. N Engl J Med 300:530\u2013534","journal-title":"N Engl J Med"},{"key":"8368_CR15","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1743-422X-8-62","volume":"8","author":"G Lu","year":"2011","unstructured":"Lu G, Gonzalez R, Guo L et al (2011) Large-scale seroprevalence analysis of human metapneumovirus and human respiratory syncytial virus infections in Beijing, China. Virol J 8:62","journal-title":"Virol J"},{"key":"8368_CR16","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/S0022-3476(81)80829-3","volume":"98","author":"WP Glezen","year":"1981","unstructured":"Glezen WP, Paredes A, Allison JE, Taber LH, Frank AL (1981) Risk of respiratory syncytial virus infection for infants from low-income families in relationship to age, sex, ethnic group, and maternal antibody level. J Pediatr 98:708\u2013715","journal-title":"J Pediatr"},{"key":"8368_CR17","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1097\/01.inf.0000226912.88900.a3","volume":"25","author":"MM Kusel","year":"2006","unstructured":"Kusel MM, de Klerk NH, Holt PG, Kebadze T, Johnston SL, Sly PD (2006) Role of respiratory viruses in acute upper and lower respiratory tract illness in the first year of life: a birth cohort study. Pediatr Infect Dis J 25:680\u2013686","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1542\/peds.2010-0581","volume":"127","author":"ML Houben","year":"2011","unstructured":"Houben ML, Bont L, Wilbrink B et al (2011) Clinical prediction rule for RSV bronchiolitis in healthy newborns: prognostic birth cohort study. Pediatrics 127:35\u201341","journal-title":"Pediatrics"},{"key":"8368_CR19","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/oxfordjournals.aje.a121550","volume":"98","author":"HW Kim","year":"1973","unstructured":"Kim HW, Arrobio JO, Brandt CD et al (1973) Epidemiology of respiratory syncytial virus infection in Washington, D.C. I. Importance of the virus in different respiratory tract disease syndromes and temporal distribution of infection. Am J Epidemiol 98:216\u2013225","journal-title":"Am J Epidemiol"},{"key":"8368_CR20","doi-asserted-by":"crossref","first-page":"e491","DOI":"10.1371\/journal.pone.0000491","volume":"2","author":"S Broor","year":"2007","unstructured":"Broor S, Parveen S, Bharaj P et al (2007) A prospective three-year cohort study of the epidemiology and virology of acute respiratory infections of children in rural India. PLoS One 2:e491","journal-title":"PLoS One"},{"key":"8368_CR21","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(10)60206-1","volume":"375","author":"H Nair","year":"2010","unstructured":"Nair H, Nokes DJ, Gessner BD et al (2010) Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet 375:1545\u20131555","journal-title":"Lancet"},{"key":"8368_CR22","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0022-3476(05)90000-0","volume":"121","author":"L Navas","year":"1992","unstructured":"Navas L, Wang E, de Carvalho V, Robinson J (1992) Improved outcome of respiratory syncytial virus infection in a high-risk hospitalized population of Canadian children. Pediatric Investigators Collaborative Network on Infections in Canada. J Pediatr 121:348\u2013354","journal-title":"J Pediatr"},{"key":"8368_CR23","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1086\/322657","volume":"33","author":"CB Hall","year":"2001","unstructured":"Hall CB, Long CE, Schnabel KC (2001) Respiratory syncytial virus infections in previously healthy working adults. Clin Infect Dis 33:792\u2013796","journal-title":"Clin Infect Dis"},{"key":"8368_CR24","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2174\/187152612800100116","volume":"12","author":"EE Walsh","year":"2012","unstructured":"Walsh EE, Falsey AR (2012) Respiratory syncytial virus infection in adult populations. Infect Disord Drug Targets 12:98\u2013102","journal-title":"Infect Disord Drug Targets"},{"key":"8368_CR25","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1056\/NEJMoa043951","volume":"352","author":"AR Falsey","year":"2005","unstructured":"Falsey AR, Hennessey PA, Formica MA, Cox C, Walsh EE (2005) Respiratory syncytial virus infection in elderly and high-risk adults. N Engl J Med 352:1749\u20131759","journal-title":"N Engl J Med"},{"key":"8368_CR26","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1183\/09031936.00034407","volume":"30","author":"AG Jansen","year":"2007","unstructured":"Jansen AG, Sanders EA, Hoes AW, van Loon AM, Hak E (2007) Influenza- and respiratory syncytial virus-associated mortality and hospitalisations. Eur Respir J 30:1158\u20131166","journal-title":"Eur Respir J"},{"key":"8368_CR27","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1542\/peds.2006-2223","volume":"118","author":"American Academy of Pediatrics and Subcommittee on the Diagnosis and Management of Bronchiolitis","year":"2006","unstructured":"American Academy of Pediatrics and Subcommittee on the Diagnosis and Management of Bronchiolitis (2006) Diagnosis and management of bronchiolitis. Pediatrics 118:1774\u20131793","journal-title":"Pediatrics"},{"key":"8368_CR28","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/INF.0b013e31818ee0c1","volume":"28","author":"T Jartti","year":"2009","unstructured":"Jartti T, Lehtinen P, Vuorinen T, Ruuskanen O (2009) Bronchiolitis: age and previous wheezing episodes are linked to viral etiology and atopic characteristics. Pediatr Infect Dis J 28:311\u2013317","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR29","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1542\/peds.113.6.1728","volume":"113","author":"DA Levine","year":"2004","unstructured":"Levine DA, Platt SL, Dayan PS et al (2004) Risk of serious bacterial infection in young febrile infants with respiratory syncytial virus infections. Pediatrics 113:1728\u20131734","journal-title":"Pediatrics"},{"key":"8368_CR30","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1097\/01.inf.0000143647.88873.66","volume":"23","author":"AG Randolph","year":"2004","unstructured":"Randolph AG, Reder L, Englund JA (2004) Risk of bacterial infection in previously healthy respiratory syncytial virus-infected young children admitted to the intensive care unit. Pediatr Infect Dis J 23:990\u2013994","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR31","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1001\/archpedi.156.4.322","volume":"156","author":"K Purcell","year":"2002","unstructured":"Purcell K, Fergie J (2002) Concurrent serious bacterial infections in 2396 infants and children hospitalized with respiratory syncytial virus lower respiratory tract infections. Arch Pediatr Adolesc Med 156:322\u2013324","journal-title":"Arch Pediatr Adolesc Med"},{"key":"8368_CR32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/01.inf.0000116759.21252.29","volume":"23","author":"K Purcell","year":"2004","unstructured":"Purcell K, Fergie J (2004) Concurrent serious bacterial infections in 912 infants and children hospitalized for treatment of respiratory syncytial virus lower respiratory tract infection. Pediatr Infect Dis J 23:267\u2013269","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR33","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1542\/peds.112.2.282","volume":"112","author":"MO Titus","year":"2003","unstructured":"Titus MO, Wright SW (2003) Prevalence of serious bacterial infections in febrile infants with respiratory syncytial virus infection. Pediatrics 112:282\u2013284","journal-title":"Pediatrics"},{"key":"8368_CR34","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1136\/adc.2004.049551","volume":"89","author":"L Duttweiler","year":"2004","unstructured":"Duttweiler L, Nadal D, Frey B (2004) Pulmonary and systemic bacterial co-infections in severe RSV bronchiolitis. Arch Dis Child 89:1155\u20131157","journal-title":"Arch Dis Child"},{"key":"8368_CR35","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1651-2227.2007.00226.x","volume":"96","author":"B Resch","year":"2007","unstructured":"Resch B, Gusenleitner W, Mueller WD (2007) Risk of concurrent bacterial infection in preterm infants hospitalized due to respiratory syncytial virus infection. Acta Paediatr 96:495\u2013498","journal-title":"Acta Paediatr"},{"key":"8368_CR36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0928-0197(97)00060-3","volume":"8","author":"F Freymuth","year":"1997","unstructured":"Freymuth F, Vabret A, Galateau-Salle F et al (1997) Detection of respiratory syncytial virus, parainfluenzavirus 3, adenovirus and rhinovirus sequences in respiratory tract of infants by polymerase chain reaction and hybridization. Clin Diagn Virol 8:31\u201340","journal-title":"Clin Diagn Virol"},{"key":"8368_CR37","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1002\/jmv.20725","volume":"78","author":"F Freymuth","year":"2006","unstructured":"Freymuth F, Vabret A, Cuvillon-Nimal D et al (2006) Comparison of multiplex PCR assays and conventional techniques for the diagnostic of respiratory virus infections in children admitted to hospital with an acute respiratory illness. J Med Virol 78:1498\u20131504","journal-title":"J Med Virol"},{"key":"8368_CR38","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1128\/JCM.00216-06","volume":"44","author":"J Kuypers","year":"2006","unstructured":"Kuypers J, Wright N, Ferrenberg J et al (2006) Comparison of real-time PCR assays with fluorescent-antibody assays for diagnosis of respiratory virus infections in children. J Clin Microbiol 44:2382\u20132388","journal-title":"J Clin Microbiol"},{"key":"8368_CR39","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/INF.0b013e31815b4935","volume":"27","author":"N Richard","year":"2008","unstructured":"Richard N, Komurian-Pradel F, Javouhey E et al (2008) The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis. Pediatr Infect Dis J 27:213\u2013217","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR40","doi-asserted-by":"crossref","first-page":"e1220","DOI":"10.1542\/peds.2011-1943","volume":"129","author":"LR Bulkow","year":"2012","unstructured":"Bulkow LR, Singleton RJ, DeByle C et al (2012) Risk factors for hospitalization with lower respiratory tract infections in children in rural Alaska. Pediatrics 129:e1220\u2013e1227","journal-title":"Pediatrics"},{"key":"8368_CR41","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jaci.2005.06.024","volume":"116","author":"RF Lemanske Jr","year":"2005","unstructured":"Lemanske RF Jr, Jackson DJ, Gangnon RE et al (2005) Rhinovirus illnesses during infancy predict subsequent childhood wheezing. J Allergy Clin Immunol 116:571\u2013577","journal-title":"J Allergy Clin Immunol"},{"key":"8368_CR42","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1056\/NEJMoa0804877","volume":"360","author":"CB Hall","year":"2009","unstructured":"Hall CB, Weinberg GA, Iwane MK et al (2009) The burden of respiratory syncytial virus infection in young children. N Engl J Med 360:588\u2013598","journal-title":"N Engl J Med"},{"key":"8368_CR43","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1542\/peds.113.6.1758","volume":"113","author":"MK Iwane","year":"2004","unstructured":"Iwane MK, Edwards KM, Szilagyi PG et al (2004) Population-based surveillance for hospitalizations associated with respiratory syncytial virus, influenza virus, and parainfluenza viruses among young children. Pediatrics 113:1758\u20131764","journal-title":"Pediatrics"},{"key":"8368_CR44","doi-asserted-by":"crossref","first-page":"e437","DOI":"10.1542\/peds.2004-0049","volume":"114","author":"RC Holman","year":"2004","unstructured":"Holman RC, Curns AT, Cheek JE et al (2004) Respiratory syncytial virus hospitalizations among American Indian and Alaska Native infants and the general United States infant population. Pediatrics 114:e437\u2013e444","journal-title":"Pediatrics"},{"key":"8368_CR45","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1093\/cid\/cis211","volume":"54","author":"H Zhou","year":"2012","unstructured":"Zhou H, Thompson WW, Viboud CG et al (2012) Hospitalizations associated with influenza and respiratory syncytial virus in the United States, 1993\u20132008. Clin Infect Dis 54:1427\u20131436","journal-title":"Clin Infect Dis"},{"key":"8368_CR46","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/INF.0b013e31822e68e6","volume":"31","author":"LJ Stockman","year":"2012","unstructured":"Stockman LJ, Curns AT, Anderson LJ, Fischer-Langley G (2012) Respiratory syncytial virus-associated hospitalizations among infants and young children in the United States, 1997\u20132006. Pediatr Infect Dis J 31:5\u20139","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR47","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1097\/01.inf.0000245104.26996.57","volume":"25","author":"RJ Singleton","year":"2006","unstructured":"Singleton RJ, Bruden D, Bulkow LR, Varney G, Butler JC (2006) Decline in respiratory syncytial virus hospitalizations in a region with high hospitalization rates and prolonged season. Pediatr Infect Dis J 25:1116\u20131122","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR48","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/22423982.2001.12113040","volume":"60","author":"A Banerji","year":"2001","unstructured":"Banerji A (2001) High rates of hospitalisation for bronchiolitis in Inuit children on Baffin Island. Int J Circumpolar Health 60:375\u2013379","journal-title":"Int J Circumpolar Health"},{"key":"8368_CR49","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1080\/25761900.2022.12220645","volume":"60","author":"P Orr","year":"2001","unstructured":"Orr P, McDonald S, Milley D, Brown R (2001) Bronchiolitis in Inuit children from a Canadian central arctic community, 1995\u20131996. Int J Circumpolar Health 60:649\u2013658","journal-title":"Int J Circumpolar Health"},{"key":"8368_CR50","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1001\/jama.282.15.1440","volume":"282","author":"DK Shay","year":"1999","unstructured":"Shay DK, Holman RC, Newman RD, Liu LL, Stout JW, Anderson LJ (1999) Bronchiolitis-associated hospitalizations among US children, 1980\u20131996. JAMA 282:1440\u20131446","journal-title":"JAMA"},{"key":"8368_CR51","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1017\/S0950268803008926","volume":"131","author":"D Vicente","year":"2003","unstructured":"Vicente D, Montes M, Cilla G, Perez-Yarza EG, Perez-Trallero E (2003) Hospitalization for respiratory syncytial virus in the paediatric population in Spain. Epidemiol Infect 131:867\u2013872","journal-title":"Epidemiol Infect"},{"key":"8368_CR52","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jcv.2006.12.005","volume":"38","author":"C Manoha","year":"2007","unstructured":"Manoha C, Espinosa S, Aho SL, Huet F, Pothier P (2007) Epidemiological and clinical features of hMPV, RSV and RVs infections in young children. J Clin Virol 38:221\u2013226","journal-title":"J Clin Virol"},{"key":"8368_CR53","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/01.inf.0000207395.80657.cf","volume":"25","author":"DG Wolf","year":"2006","unstructured":"Wolf DG, Greenberg D, Kalkstein D et al (2006) Comparison of human metapneumovirus, respiratory syncytial virus and influenza A virus lower respiratory tract infections in hospitalized young children. Pediatr Infect Dis J 25:320\u2013324","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR54","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1164\/rccm.200112-118BC","volume":"165","author":"NG Papadopoulos","year":"2002","unstructured":"Papadopoulos NG, Moustaki M, Tsolia M et al (2002) Association of rhinovirus infection with increased disease severity in acute bronchiolitis. Am J Respir Crit Care Med 165:1285\u20131289","journal-title":"Am J Respir Crit Care Med"},{"key":"8368_CR55","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1553-2712.2007.00034.x","volume":"15","author":"JM Mansbach","year":"2008","unstructured":"Mansbach JM, McAdam AJ, Clark S et al (2008) Prospective multicenter study of the viral etiology of bronchiolitis in the emergency department. Acad Emerg Med 15:111\u2013118","journal-title":"Acad Emerg Med"},{"key":"8368_CR56","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1651-2227.2008.01023.x","volume":"98","author":"HE Stempel","year":"2009","unstructured":"Stempel HE, Martin ET, Kuypers J, Englund JA, Zerr DM (2009) Multiple viral respiratory pathogens in children with bronchiolitis. Acta Paediatr 98:123\u2013126","journal-title":"Acta Paediatr"},{"key":"8368_CR57","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1651-2227.2010.01714.x","volume":"99","author":"C Calvo","year":"2010","unstructured":"Calvo C, Pozo F, Garcia-Garcia ML et al (2010) Detection of new respiratory viruses in hospitalized infants with bronchiolitis: a three-year prospective study. Acta Paediatr 99:883\u2013887","journal-title":"Acta Paediatr"},{"key":"8368_CR58","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1007\/s10096-011-1529-y","volume":"31","author":"D Herv\u00e1s","year":"2012","unstructured":"Herv\u00e1s D, Reina J, Ya\u00f1ez A, Del Valle JM, Figuerola J, Herv\u00e1s JA (2012) Epidemiology of hospitalization for acute bronchiolitis in children: differences between RSV and non-RSV bronchiolitis. Eur J Clin Microbiol Infect Dis 31:1975\u20131981","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"8368_CR59","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1590\/S1807-59322010001100014","volume":"65","author":"MS Nascimento","year":"2010","unstructured":"Nascimento MS, Souza AV, Ferreira AV, Rodrigues JC, Abramovici S, Silva Filho LV (2010) High rate of viral identification and coinfections in infants with acute bronchiolitis. Clinics (S\u00e3o Paulo) 65:1133\u20131137","journal-title":"Clinics (S\u00e3o Paulo)"},{"key":"8368_CR60","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/01.inf.0000207480.55201.f6","volume":"25","author":"V Foulongne","year":"2006","unstructured":"Foulongne V, Guyon G, Rodiere M, Segondy M (2006) Human metapneumovirus infection in young children hospitalized with respiratory tract disease. Pediatr Infect Dis J 25:354\u2013359","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR61","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1128\/JCM.05999-11","volume":"50","author":"RL Atmar","year":"2012","unstructured":"Atmar RL, Piedra PA, Patel SM, Greenberg SB, Couch RB, Glezen WP (2012) Picornavirus, the most common respiratory virus causing infection among patients of all ages hospitalized with acute respiratory illness. J Clin Microbiol 50:506\u2013508","journal-title":"J Clin Microbiol"},{"key":"8368_CR62","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/01.inf.0000168747.94999.aa","volume":"24","author":"JP Legg","year":"2005","unstructured":"Legg JP, Warner JA, Johnston SL, Warner JO (2005) Frequency of detection of picornaviruses and seven other respiratory pathogens in infants. Pediatr Infect Dis J 24:611\u2013616","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR63","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1097\/01.inf.0000143642.72480.53","volume":"23","author":"M Korppi","year":"2004","unstructured":"Korppi M, Kotaniemi-Syrjanen A, Waris M, Vainionpaa R, Reijonen TM (2004) Rhinovirus-associated wheezing in infancy: comparison with respiratory syncytial virus bronchiolitis. Pediatr Infect Dis J 23:995\u2013999","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR64","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/j.1399-3038.2010.01059.x","volume":"21","author":"T Jartti","year":"2010","unstructured":"Jartti T, Kuusipalo H, Vuorinen T et al (2010) Allergic sensitization is associated with rhinovirus-, but not other virus-, induced wheezing in children. Pediatr Allergy Immunol 21:1008\u20131014","journal-title":"Pediatr Allergy Immunol"},{"key":"8368_CR65","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1067\/mpd.2000.110531","volume":"137","author":"TG Boyce","year":"2000","unstructured":"Boyce TG, Mellen BG, Mitchel EF Jr, Wright PF, Griffin MR (2000) Rates of hospitalization for respiratory syncytial virus infection among children in Medicaid. J Pediatr 137:865\u2013870","journal-title":"J Pediatr"},{"key":"8368_CR66","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1651-2227.2002.tb03282.x","volume":"91","author":"M Eriksson","year":"2002","unstructured":"Eriksson M, Bennet R, Rotzen-Ostlund M, von Sydow M, Wirgart BZ (2002) Population-based rates of severe respiratory syncytial virus infection in children with and without risk factors, and outcome in a tertiary care setting. Acta Paediatr 91:593\u2013598","journal-title":"Acta Paediatr"},{"key":"8368_CR67","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1136\/adc.88.12.1065","volume":"88","author":"SA Deshpande","year":"2003","unstructured":"Deshpande SA, Northern V (2003) The clinical and health economic burden of respiratory syncytial virus disease among children under 2 years of age in a defined geographical area. Arch Dis Child 88:1065\u20131069","journal-title":"Arch Dis Child"},{"key":"8368_CR68","doi-asserted-by":"crossref","unstructured":"Gouyon JB, Roz\u00e9 JC, Guillermet-Fromentin C et al (2012) Hospitalizations for respiratory syncytial virus bronchiolitis in preterm infants at <33 weeks gestation without bronchopulmonary dysplasia: the CASTOR study. Epidemiol Infect 1\u201311","DOI":"10.1017\/S0950268812001069"},{"key":"8368_CR69","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1093\/cid\/cir928","volume":"54","author":"K Kristensen","year":"2012","unstructured":"Kristensen K, Hjuler T, Ravn H, Simoes EA, Stensballe LG (2012) Chronic diseases, chromosomal abnormalities, and congenital malformations as risk factors for respiratory syncytial virus hospitalization: a population-based cohort study. Clin Infect Dis 54:810\u2013817","journal-title":"Clin Infect Dis"},{"key":"8368_CR70","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2431-4-25","volume":"4","author":"HO Fjaerli","year":"2004","unstructured":"Fjaerli HO, Farstad T, Bratlid D (2004) Hospitalisations for respiratory syncytial virus bronchiolitis in Akershus, Norway, 1993\u20132000: a population-based retrospective study. BMC Pediatr 4:25","journal-title":"BMC Pediatr"},{"key":"8368_CR71","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/01.inf.0000202135.24485.f8","volume":"25","author":"E Rietveld","year":"2006","unstructured":"Rietveld E, Vergouwe Y, Steyerberg EW, Huysman MW, de Groot R, Moll HA (2006) Hospitalization for respiratory syncytial virus infection in young children: development of a clinical prediction rule. Pediatr Infect Dis J 25:201\u2013207","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR72","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s15010-002-2122-1","volume":"30","author":"B Resch","year":"2002","unstructured":"Resch B, Gusenleitner W, Muller W (2002) The impact of respiratory syncytial virus infection: a prospective study in hospitalized infants younger than 2 years. Infection 30:193\u2013197","journal-title":"Infection"},{"key":"8368_CR73","first-page":"452","volume":"20","author":"JA Weigl","year":"2001","unstructured":"Weigl JA, Puppe W, Schmitt HJ (2001) Incidence of respiratory syncytial virus-positive hospitalizations in Germany. Eur J Clin Microbiol Infect Dis 20:452\u2013459","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"8368_CR74","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1097\/INF.0b013e318257f619","volume":"31","author":"HW Park","year":"2012","unstructured":"Park HW, Lee BS, Kim AR et al (2012) Epidemiology of respiratory syncytial virus infection in infants born at less than thirty-five weeks of gestational age. Pediatr Infect Dis J 31:e99\u2013e104","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR75","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1086\/513976","volume":"175","author":"EE Walsh","year":"1997","unstructured":"Walsh EE, McConnochie KM, Long CE, Hall CB (1997) Severity of respiratory syncytial virus infection is related to virus strain. J Infect Dis 175:814\u2013820","journal-title":"J Infect Dis"},{"key":"8368_CR76","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1097\/01.inf.0000137568.71589.bd","volume":"23","author":"BJ Law","year":"2004","unstructured":"Law BJ, Langley JM, Allen U et al (2004) The Pediatric Investigators Collaborative Network on Infections in Canada study of predictors of hospitalization for respiratory syncytial virus infection for infants born at 33 through 35 completed weeks of gestation. Pediatr Infect Dis J 23:806\u2013814","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR77","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1056\/NEJM198607103150201","volume":"315","author":"CB Hall","year":"1986","unstructured":"Hall CB, Powell KR, MacDonald NE et al (1986) Respiratory syncytial viral infection in children with compromised immune function. N Engl J Med 315:77\u201381","journal-title":"N Engl J Med"},{"key":"8368_CR78","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1111\/j.1651-2227.2003.tb00502.x","volume":"92","author":"HE Nielsen","year":"2003","unstructured":"Nielsen HE, Siersma V, Andersen S et al (2003) Respiratory syncytial virus infection\u2013risk factors for hospital admission: a case-control study. Acta Paediatr 92:1314\u20131321","journal-title":"Acta Paediatr"},{"key":"8368_CR79","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1542\/peds.2004-0059","volume":"115","author":"JP Bradley","year":"2005","unstructured":"Bradley JP, Bacharier LB, Bonfiglio J et al (2005) Severity of respiratory syncytial virus bronchiolitis is affected by cigarette smoke exposure and atopy. Pediatrics 115:e7\u2013e14","journal-title":"Pediatrics"},{"key":"8368_CR80","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1097\/00006454-200109000-00010","volume":"20","author":"X Carbonell-Estrany","year":"2001","unstructured":"Carbonell-Estrany X, Quero J (2001) Hospitalization rates for respiratory syncytial virus infection in premature infants born during two consecutive seasons. Pediatr Infect Dis J 20:874\u2013879","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR81","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1097\/01.inf.0000136869.21397.6b","volume":"23","author":"J Figueras-Aloy","year":"2004","unstructured":"Figueras-Aloy J, Carbonell-Estrany X, Quero J (2004) Case-control study of the risk factors linked to respiratory syncytial virus infection requiring hospitalization in premature infants born at a gestational age of 33\u201335 weeks in Spain. Pediatr Infect Dis J 23:815\u2013820","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR82","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1097\/INF.0b013e3181710990","volume":"27","author":"J Figueras-Aloy","year":"2008","unstructured":"Figueras-Aloy J, Carbonell-Estrany X, Quero-Jimenez J et al (2008) FLIP-2 Study: risk factors linked to respiratory syncytial virus infection requiring hospitalization in premature infants born in Spain at a gestational age of 32 to 35 weeks. Pediatr Infect Dis J 27:788\u2013793","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR83","doi-asserted-by":"crossref","first-page":"e1360","DOI":"10.1542\/peds.2006-0907","volume":"118","author":"LG Stensballe","year":"2006","unstructured":"Stensballe LG, Kristensen K, Simoes EA et al (2006) Atopic disposition, wheezing, and subsequent respiratory syncytial virus hospitalization in Danish children younger than 18 months: a nested case-control study. Pediatrics 118:e1360\u2013e1368","journal-title":"Pediatrics"},{"key":"8368_CR84","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1097\/01.inf.0000246978.58565.b5","volume":"25","author":"G Doering","year":"2006","unstructured":"Doering G, Gusenleitner W, Belohradsky BH, Burdach S, Resch B, Liese JG (2006) The risk of respiratory syncytial virus-related hospitalizations in preterm infants of 29 to 35 weeks\u2019 gestational age. Pediatr Infect Dis J 25:1188\u20131190","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR85","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1542\/peds.109.2.210","volume":"109","author":"LR Bulkow","year":"2002","unstructured":"Bulkow LR, Singleton RJ, Karron RA, Harrison LH (2002) Risk factors for severe respiratory syncytial virus infection among Alaska native children. Pediatrics 109:210\u2013216","journal-title":"Pediatrics"},{"key":"8368_CR86","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1017\/S104795110700042X","volume":"17","author":"C Medrano","year":"2007","unstructured":"Medrano C, Garcia-Guereta L, Grueso J et al (2007) Respiratory infection in congenital cardiac disease. Hospitalizations in young children in Spain during 2004 and 2005: the CIVIC Epidemiologic Study. Cardiol Young 17:360\u2013371","journal-title":"Cardiol Young"},{"key":"8368_CR87","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1136\/thx.2004.037853","volume":"60","author":"S Broughton","year":"2005","unstructured":"Broughton S, Roberts A, Fox G et al (2005) Prospective study of healthcare utilisation and respiratory morbidity due to RSV infection in prematurely born infants. Thorax 60:1039\u20131044","journal-title":"Thorax"},{"key":"8368_CR88","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1177\/0009922806291012","volume":"45","author":"R Somech","year":"2006","unstructured":"Somech R, Tal G, Gilad E, Mandelberg A, Tal A, Dalal I (2006) Epidemiologic, socioeconomic, and clinical factors associated with severity of respiratory syncytial virus infection in previously healthy infants. Clin Pediatr (Phila) 45:621\u2013627","journal-title":"Clin Pediatr (Phila)"},{"key":"8368_CR89","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/(SICI)1096-9071(199705)52:1<97::AID-JMV16>3.0.CO;2-Y","volume":"52","author":"AH Brandenburg","year":"1997","unstructured":"Brandenburg AH, Groen J, van Steensel-Moll HA et al (1997) Respiratory syncytial virus specific serum antibodies in infants under six months of age: limited serological response upon infection. J Med Virol 52:97\u2013104","journal-title":"J Med Virol"},{"key":"8368_CR90","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/oxfordjournals.aje.a121558","volume":"98","author":"RH Parrott","year":"1973","unstructured":"Parrott RH, Kim HW, Arrobio JO et al (1973) Epidemiology of respiratory syncytial virus infection in Washington, D.C. II. Infection and disease with respect to age, immunologic status, race and sex. Am J Epidemiol 98:289\u2013300","journal-title":"Am J Epidemiol"},{"key":"8368_CR91","doi-asserted-by":"crossref","first-page":"e8088","DOI":"10.1371\/journal.pone.0008088","volume":"4","author":"R Ochola","year":"2009","unstructured":"Ochola R, Sande C, Fegan G et al (2009) The level and duration of RSV-specific maternal IgG in infants in Kilifi Kenya. PLoS One 4:e8088","journal-title":"PLoS One"},{"key":"8368_CR92","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/jmv.10148","volume":"67","author":"A Roca","year":"2002","unstructured":"Roca A, Abacassamo F, Loscertales MP et al (2002) Prevalence of respiratory syncytial virus IgG antibodies in infants living in a rural area of Mozambique. J Med Virol 67:616\u2013623","journal-title":"J Med Virol"},{"key":"8368_CR93","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1093\/oxfordjournals.aje.a115826","volume":"133","author":"CJ Holberg","year":"1991","unstructured":"Holberg CJ, Wright AL, Martinez FD, Ray CG, Taussig LM, Lebowitz MD (1991) Risk factors for respiratory syncytial virus-associated lower respiratory illnesses in the first year of life. Am J Epidemiol 133:1135\u20131151","journal-title":"Am J Epidemiol"},{"key":"8368_CR94","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jaci.2008.10.043","volume":"123","author":"LG Stensballe","year":"2009","unstructured":"Stensballe LG, Ravn H, Kristensen K et al (2009) Respiratory syncytial virus neutralizing antibodies in cord blood, respiratory syncytial virus hospitalization, and recurrent wheeze. J Allergy Clin Immunol 123:398\u2013403","journal-title":"J Allergy Clin Immunol"},{"key":"8368_CR95","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1016\/S0264-410X(03)00355-4","volume":"21","author":"PA Piedra","year":"2003","unstructured":"Piedra PA, Jewell AM, Cron SG, Atmar RL, Glezen WP (2003) Correlates of immunity to respiratory syncytial virus (RSV) associated-hospitalization: establishment of minimum protective threshold levels of serum neutralizing antibodies. Vaccine 21:3479\u20133482","journal-title":"Vaccine"},{"key":"8368_CR96","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/infdis\/134.3.211","volume":"134","author":"CL Lamprecht","year":"1976","unstructured":"Lamprecht CL, Krause HE, Mufson MA (1976) Role of maternal antibody in pneumonia and bronchiolitis due to respiratory syncytial virus. J Infect Dis 134:211\u2013217","journal-title":"J Infect Dis"},{"key":"8368_CR97","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1093\/infdis\/jir494","volume":"204","author":"CM El Saleeby","year":"2011","unstructured":"El Saleeby CM, Bush AJ, Harrison LM, Aitken JA, Devincenzo JP (2011) Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children. J Infect Dis 204:996\u20131002","journal-title":"J Infect Dis"},{"key":"8368_CR98","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1002\/jmv.21026","volume":"79","author":"I Fodha","year":"2007","unstructured":"Fodha I, Vabret A, Ghedira L et al (2007) Respiratory syncytial virus infections in hospitalized infants: association between viral load, virus subgroup, and disease severity. J Med Virol 79:1951\u20131958","journal-title":"J Med Virol"},{"key":"8368_CR99","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00006454-200002000-00006","volume":"19","author":"SC Buckingham","year":"2000","unstructured":"Buckingham SC, Bush AJ, Devincenzo JP (2000) Nasal quantity of respiratory syncytical virus correlates with disease severity in hospitalized infants. Pediatr Infect Dis J 19:113\u2013117","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR100","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1086\/430008","volume":"191","author":"JP DeVincenzo","year":"2005","unstructured":"DeVincenzo JP, El Saleeby CM, Bush AJ (2005) Respiratory syncytial virus load predicts disease severity in previously healthy infants. J Infect Dis 191:1861\u20131868","journal-title":"J Infect Dis"},{"key":"8368_CR101","doi-asserted-by":"crossref","first-page":"e1038","DOI":"10.1371\/journal.pone.0001038","volume":"2","author":"MG Semple","year":"2007","unstructured":"Semple MG, Dankert HM, Ebrahimi B et al (2007) Severe respiratory syncytial virus bronchiolitis in infants is associated with reduced airway interferon gamma and substance P. PLoS One 2:e1038","journal-title":"PLoS One"},{"key":"8368_CR102","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1086\/339822","volume":"185","author":"PF Wright","year":"2002","unstructured":"Wright PF, Gruber WC, Peters M et al (2002) Illness severity, viral shedding, and antibody responses in infants hospitalized with bronchiolitis caused by respiratory syncytial virus. J Infect Dis 185:1011\u20131018","journal-title":"J Infect Dis"},{"key":"8368_CR103","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/jmv.21771","volume":"82","author":"ML Houben","year":"2010","unstructured":"Houben ML, Coenjaerts FE, Rossen JW et al (2010) Disease severity and viral load are correlated in infants with primary respiratory syncytial virus infection in the community. J Med Virol 82:1266\u20131271","journal-title":"J Med Virol"},{"key":"8368_CR104","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1097\/INF.0b013e318218ab9e","volume":"30","author":"EA Simoes","year":"2011","unstructured":"Simoes EA, Mutyara K, Soh S, Agustian D, Hibberd ML, Kartasasmita CB (2011) The epidemiology of respiratory syncytial virus lower respiratory tract infections in children less than 5 years of age in Indonesia. Pediatr Infect Dis J 30:778\u2013784","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR105","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0022-3476(05)82443-6","volume":"117","author":"KM McConnochie","year":"1990","unstructured":"McConnochie KM, Hall CB, Walsh EE, Roghmann KJ (1990) Variation in severity of respiratory syncytial virus infections with subtype. J Pediatr 117:52\u201362","journal-title":"J Pediatr"},{"key":"8368_CR106","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1097\/00006454-199812000-00003","volume":"17","author":"A Hornsleth","year":"1998","unstructured":"Hornsleth A, Klug B, Nir M et al (1998) Severity of respiratory syncytial virus disease related to type and genotype of virus and to cytokine values in nasopharyngeal secretions. Pediatr Infect Dis J 17:1114\u20131121","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR107","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.clim.2007.03.003","volume":"123","author":"SC Paulus","year":"2007","unstructured":"Paulus SC, Hirschfeld AF, Victor RE, Brunstein J, Thomas E, Turvey SE (2007) Common human Toll-like receptor 4 polymorphisms\u2013role in susceptibility to respiratory syncytial virus infection and functional immunological relevance. Clin Immunol 123:252\u2013257","journal-title":"Clin Immunol"},{"key":"8368_CR108","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/jmv.21067","volume":"80","author":"NM Kaplan","year":"2008","unstructured":"Kaplan NM, Dove W, Abd-Eldayem SA, Abu-Zeid AF, Shamoon HE, Hart CA (2008) Molecular epidemiology and disease severity of respiratory syncytial virus in relation to other potential pathogens in children hospitalized with acute respiratory infection in Jordan. J Med Virol 80:168\u2013174","journal-title":"J Med Virol"},{"key":"8368_CR109","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1086\/342414","volume":"186","author":"RA Martinello","year":"2002","unstructured":"Martinello RA, Chen MD, Weibel C, Kahn JS (2002) Correlation between respiratory syncytial virus genotype and severity of illness. J Infect Dis 186:839\u2013842","journal-title":"J Infect Dis"},{"key":"8368_CR110","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1097\/01.inf.0000145531.65979.cf","volume":"23","author":"A Struck","year":"2004","unstructured":"Struck A, Forster J, Ihorst G, Werchau H, Konig W, Konig B (2004) Respiratory syncytial virus: G gene genotype and disease severity. Pediatr Infect Dis J 23:1000\u20131002","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR111","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.arcmed.2005.08.007","volume":"37","author":"C Savon","year":"2006","unstructured":"Savon C, Goyenechea A, Valdes O et al (2006) Respiratory syncytial virus group A and B genotypes and disease severity among Cuban children. Arch Med Res 37:543\u2013547","journal-title":"Arch Med Res"},{"key":"8368_CR112","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/ppul.10080","volume":"33","author":"RL Smyth","year":"2002","unstructured":"Smyth RL, Mobbs KJ, O\u2019Hea U, Ashby D, Hart CA (2002) Respiratory syncytial virus bronchiolitis: disease severity, interleukin-8, and virus genotype. Pediatr Pulmonol 33:339\u2013346","journal-title":"Pediatr Pulmonol"},{"key":"8368_CR113","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.micpath.2011.12.006","volume":"52","author":"W Wu","year":"2012","unstructured":"Wu W, Macdonald A, Hiscox JA, Barr JN (2012) Different NF-kappaB activation characteristics of human respiratory syncytial virus subgroups A and B. Microb Pathog 52:184\u2013191","journal-title":"Microb Pathog"},{"key":"8368_CR114","doi-asserted-by":"crossref","first-page":"5782","DOI":"10.1128\/JVI.01693-10","volume":"85","author":"KL Stokes","year":"2011","unstructured":"Stokes KL, Chi MH, Sakamoto K et al (2011) Differential pathogenesis of respiratory syncytial virus clinical isolates in BALB\/c mice. J Virol 85:5782\u20135793","journal-title":"J Virol"},{"key":"8368_CR115","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1128\/JVI.01853-08","volume":"83","author":"ML Moore","year":"2009","unstructured":"Moore ML, Chi MH, Luongo C et al (2009) A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction. J Virol 83:4185\u20134194","journal-title":"J Virol"},{"key":"8368_CR116","doi-asserted-by":"crossref","first-page":"977","DOI":"10.2353\/ajpath.2006.051055","volume":"169","author":"NW Lukacs","year":"2006","unstructured":"Lukacs NW, Moore ML, Rudd BD et al (2006) Differential immune responses and pulmonary pathophysiology are induced by two different strains of respiratory syncytial virus. Am J Pathol 169:977\u2013986","journal-title":"Am J Pathol"},{"key":"8368_CR117","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1743-422X-8-43","volume":"8","author":"R Villenave","year":"2011","unstructured":"Villenave R, O\u2019Donoghue D, Thavagnanam S et al (2011) Differential cytopathogenesis of respiratory syncytial virus prototypic and clinical isolates in primary pediatric bronchial epithelial cells. Virol J 8:43","journal-title":"Virol J"},{"key":"8368_CR118","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/1743-422X-9-190","volume":"9","author":"R Levitz","year":"2012","unstructured":"Levitz R, Wattier R, Phillips P et al (2012) Induction of IL-6 and CCL5 (RANTES) in human respiratory epithelial (A549) cells by clinical isolates of respiratory syncytial virus is strain specific. Virol J 9:190","journal-title":"Virol J"},{"key":"8368_CR119","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/jmv.22217","volume":"84","author":"T Ursic","year":"2012","unstructured":"Ursic T, Jevsnik M, Zigon N et al (2012) Human bocavirus and other respiratory viral infections in a 2-year cohort of hospitalized children. J Med Virol 84:99\u2013108","journal-title":"J Med Virol"},{"key":"8368_CR120","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1097\/01.inf.0000143648.04673.6c","volume":"23","author":"LC Jennings","year":"2004","unstructured":"Jennings LC, Anderson TP, Werno AM, Beynon KA, Murdoch DR (2004) Viral etiology of acute respiratory tract infections in children presenting to hospital: role of polymerase chain reaction and demonstration of multiple infections. Pediatr Infect Dis J 23:1003\u20131007","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR121","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jcv.2008.03.012","volume":"42","author":"C Calvo","year":"2008","unstructured":"Calvo C, Garcia-Garcia ML, Blanco C et al (2008) Multiple simultaneous viral infections in infants with acute respiratory tract infections in Spain. J Clin Virol 42:268\u2013272","journal-title":"J Clin Virol"},{"key":"8368_CR122","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1136\/adc.2008.153361","volume":"95","author":"F Midulla","year":"2010","unstructured":"Midulla F, Scagnolari C, Bonci E et al (2010) Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants. Arch Dis Child 95:35\u201341","journal-title":"Arch Dis Child"},{"key":"8368_CR123","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1086\/426457","volume":"191","author":"MG Semple","year":"2005","unstructured":"Semple MG, Cowell A, Dove W et al (2005) Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis. J Infect Dis 191:382\u2013386","journal-title":"J Infect Dis"},{"key":"8368_CR124","doi-asserted-by":"crossref","first-page":"4632","DOI":"10.1128\/JCM.42.10.4632-4635.2004","volume":"42","author":"B K\u00f6nig","year":"2004","unstructured":"K\u00f6nig B, K\u00f6nig W, Arnold R, Werchau H, Ihorst G, Forster J (2004) Prospective study of human metapneumovirus infection in children less than 3 years of age. J Clin Microbiol 42:4632\u20134635","journal-title":"J Clin Microbiol"},{"key":"8368_CR125","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/01.inf.0000168741.59747.2d","volume":"24","author":"JH Aberle","year":"2005","unstructured":"Aberle JH, Aberle SW, Pracher E, Hutter HP, Kundi M, Popow-Kraupp T (2005) Single versus dual respiratory virus infections in hospitalized infants: impact on clinical course of disease and interferon-gamma response. Pediatr Infect Dis J 24:605\u2013610","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR126","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3201\/eid0903.020289","volume":"9","author":"J Greensill","year":"2003","unstructured":"Greensill J, McNamara PS, Dove W, Flanagan B, Smyth RL, Hart CA (2003) Human metapneumovirus in severe respiratory syncytial virus bronchiolitis. Emerg Infect Dis 9:372\u2013375","journal-title":"Emerg Infect Dis"},{"key":"8368_CR127","doi-asserted-by":"crossref","unstructured":"Fernandes RM, Bialy LM, Vandermeer B et al (2010) Glucocorticoids for acute viral bronchiolitis in infants and young children. Cochrane Database Syst Rev CD004878","DOI":"10.1002\/14651858.CD004878.pub3"},{"key":"8368_CR128","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1056\/NEJMoa0900544","volume":"360","author":"AC Plint","year":"2009","unstructured":"Plint AC, Johnson DW, Patel H et al (2009) Epinephrine and dexamethasone in children with bronchiolitis. N Engl J Med 360:2079\u20132089","journal-title":"N Engl J Med"},{"key":"8368_CR129","doi-asserted-by":"crossref","first-page":"e878","DOI":"10.1542\/peds.2005-2119","volume":"117","author":"RA Pinto","year":"2006","unstructured":"Pinto RA, Arredondo SM, Bono MR, Gaggero AA, Diaz PV (2006) T helper 1\/T helper 2 cytokine imbalance in respiratory syncytial virus infection is associated with increased endogenous plasma cortisol. Pediatrics 117:e878\u2013e886","journal-title":"Pediatrics"},{"key":"8368_CR130","doi-asserted-by":"crossref","unstructured":"Blom D, Ermers M, Bont L, van Aalderen WM, van Woensel JB (2007) Inhaled corticosteroids during acute bronchiolitis in the prevention of post-bronchiolitic wheezing. Cochrane Database Syst Rev CD004881","DOI":"10.1002\/14651858.CD004881.pub2"},{"key":"8368_CR131","doi-asserted-by":"crossref","first-page":"b897","DOI":"10.1136\/bmj.b897","volume":"338","author":"MJ Ermers","year":"2009","unstructured":"Ermers MJ, Rovers MM, van Woensel JB, Kimpen JL, Bont LJ (2009) The effect of high dose inhaled corticosteroids on wheeze in infants after respiratory syncytial virus infection: randomised double blind placebo controlled trial. BMJ 338:b897","journal-title":"BMJ"},{"key":"8368_CR132","doi-asserted-by":"crossref","unstructured":"Ventre K, Randolph AG (2007) Ribavirin for respiratory syncytial virus infection of the lower respiratory tract in infants and young children. Cochrane Database Syst Rev CD000181","DOI":"10.1002\/14651858.CD000181.pub3"},{"key":"8368_CR133","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1007\/s00134-005-2614-4","volume":"31","author":"MC Kneyber","year":"2005","unstructured":"Kneyber MC, Blusse van Oud-Alblas H, van Vliet M, Uiterwaal CS, Kimpen JL, van Vught AJ (2005) Concurrent bacterial infection and prolonged mechanical ventilation in infants with respiratory syncytial virus lower respiratory tract disease. Intensive Care Med 31:680\u2013685","journal-title":"Intensive Care Med"},{"key":"8368_CR134","doi-asserted-by":"crossref","unstructured":"Spurling GK, Doust J, Del Mar CB, Eriksson L (2011) Antibiotics for bronchiolitis in children. Cochrane Database Syst Rev CD005189","DOI":"10.1002\/14651858.CD005189.pub3"},{"key":"8368_CR135","doi-asserted-by":"crossref","first-page":"e41104","DOI":"10.1371\/journal.pone.0041104","volume":"7","author":"K Ni","year":"2012","unstructured":"Ni K, Li S, Xia Q et al (2012) Pharyngeal microflora disruption by antibiotics promotes airway hyperresponsiveness after respiratory syncytial virus infection. PLoS One 7:e41104","journal-title":"PLoS One"},{"key":"8368_CR136","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.4049\/jimmunol.1100764","volume":"187","author":"KA Weiss","year":"2011","unstructured":"Weiss KA, Christiaansen AF, Fulton RB, Meyerholz DK, Varga SM (2011) Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infection. J Immunol 187:3145\u20133154","journal-title":"J Immunol"},{"key":"8368_CR137","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1128\/JVI.00036-09","volume":"83","author":"TJ Ruckwardt","year":"2009","unstructured":"Ruckwardt TJ, Bonaparte KL, Nason MC, Graham BS (2009) Regulatory T cells promote early influx of CD8+ T cells in the lungs of respiratory syncytial virus-infected mice and diminish immunodominance disparities. J Virol 83:3019\u20133028","journal-title":"J Virol"},{"key":"8368_CR138","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.4049\/jimmunol.1000423","volume":"185","author":"RB Fulton","year":"2010","unstructured":"Fulton RB, Meyerholz DK, Varga SM (2010) Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection. J Immunol 185:2382\u20132392","journal-title":"J Immunol"},{"key":"8368_CR139","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/mi.2011.62","volume":"5","author":"J Loebbermann","year":"2012","unstructured":"Loebbermann J, Thornton H, Durant L et al (2012) Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal Immunol 5:161\u2013172","journal-title":"Mucosal Immunol"},{"key":"8368_CR140","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s004310050798","volume":"157","author":"CE Behrendt","year":"1998","unstructured":"Behrendt CE, Decker MD, Burch DJ, Watson PH (1998) International variation in the management of infants hospitalized with respiratory syncytial virus. International RSV Study Group. Eur J Pediatr 157:215\u2013220","journal-title":"Eur J Pediatr"},{"key":"8368_CR141","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1542\/peds.102.3.531","volume":"102","author":"IMpact-RSV Study Group","year":"1998","unstructured":"IMpact-RSV Study Group (1998) Palivizumab, a humanized respiratory syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants. Pediatrics 102:531\u2013537","journal-title":"Pediatrics"},{"key":"8368_CR142","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1067\/S0022-3476(03)00454-2","volume":"143","author":"TF Feltes","year":"2003","unstructured":"Feltes TF, Cabalka AK, Meissner HC et al (2003) Palivizumab prophylaxis reduces hospitalization due to respiratory syncytial virus in young children with hemodynamically significant congenital heart disease. J Pediatr 143:532\u2013540","journal-title":"J Pediatr"},{"key":"8368_CR143","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1440-1754.2011.02219.x","volume":"48","author":"PM Alexander","year":"2012","unstructured":"Alexander PM, Eastaugh L, Royle J, Daley AJ, Shekerdemian LS, Penny DJ (2012) Respiratory syncytial virus immunoprophylaxis in high-risk infants with heart disease. J Paediatr Child Health 48:395\u2013401","journal-title":"J Paediatr Child Health"},{"key":"8368_CR144","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/pds.2246","volume":"21","author":"AG Winterstein","year":"2012","unstructured":"Winterstein AG, Hampp C, Saidi A (2012) Effectiveness of palivizumab prophylaxis in infants and children in Florida. Pharmacoepidemiol Drug Saf 21:53\u201360","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"8368_CR145","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/PCC.0b013e3182070990","volume":"12","author":"PA Checchia","year":"2011","unstructured":"Checchia PA, Nalysnyk L, Fernandes AW et al (2011) Mortality and morbidity among infants at high risk for severe respiratory syncytial virus infection receiving prophylaxis with palivizumab: a systematic literature review and meta-analysis. Pediatr Crit Care Med 12:580\u2013588","journal-title":"Pediatr Crit Care Med"},{"key":"8368_CR146","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/SMJ.0b013e31825ea57d","volume":"105","author":"AD Chadha","year":"2012","unstructured":"Chadha AD, Bao W, Holloway J, Mann J, Rye AK, Brown DE 3rd (2012) Respiratory syncytial virus morbidity and outpatient palivizumab dosing in South Carolina, 2004\u20132009. South Med J 105:399\u2013404","journal-title":"South Med J"},{"key":"8368_CR147","first-page":"46","volume":"16","author":"MP Frogel","year":"2010","unstructured":"Frogel MP, Stewart DL, Hoopes M, Fernandes AW, Mahadevia PJ (2010) A systematic review of compliance with palivizumab administration for RSV immunoprophylaxis. J Manag Care Pharm 16:46\u201358","journal-title":"J Manag Care Pharm"},{"key":"8368_CR148","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1542\/peds.2009-2345","volume":"124","author":"American Academy of Pediatrics and Committee on Infectious Diseases","year":"2009","unstructured":"American Academy of Pediatrics and Committee on Infectious Diseases (2009) Policy statements\u2013Modified recommendations for use of palivizumab for prevention of respiratory syncytial virus infections. Pediatrics 124:1694\u20131701","journal-title":"Pediatrics"},{"key":"8368_CR149","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1177\/0272989X08315238","volume":"28","author":"JS Sampalis","year":"2008","unstructured":"Sampalis JS, Langley J, Carbonell-Estrany X et al (2008) Development and validation of a risk scoring tool to predict respiratory syncytial virus hospitalization in premature infants born at 33 through 35 completed weeks of gestation. Med Decis Making 28:471\u2013480","journal-title":"Med Decis Making"},{"key":"8368_CR150","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1465-9921-9-78","volume":"9","author":"EA Simoes","year":"2008","unstructured":"Simoes EA, Carbonell-Estrany X, Fullarton JR et al (2008) A predictive model for respiratory syncytial virus (RSV) hospitalisation of premature infants born at 33\u201335 weeks of gestational age, based on data from the Spanish FLIP Study. Respir Res 9:78","journal-title":"Respir Res"},{"key":"8368_CR151","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1185\/03007990802484234","volume":"24","author":"KL Lanct\u00f4t","year":"2008","unstructured":"Lanct\u00f4t KL, Masoud ST, Paes BA et al (2008) The cost-effectiveness of palivizumab for respiratory syncytial virus prophylaxis in premature infants with a gestational age of 32\u201335 weeks: a Canadian-based analysis. Curr Med Res Opin 24:3223\u20133237","journal-title":"Curr Med Res Opin"},{"key":"8368_CR152","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1185\/03007990902929112","volume":"25","author":"B Paes","year":"2009","unstructured":"Paes B, Steele S, Janes M, Pinelli J (2009) Risk-Scoring Tool for respiratory syncytial virus prophylaxis in premature infants born at 33\u201335 completed weeks\u2019 gestational age in Canada. Curr Med Res Opin 25:1585\u20131591","journal-title":"Curr Med Res Opin"},{"key":"8368_CR153","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1097\/00006454-199809000-00007","volume":"17","author":"X Saez-Llorens","year":"1998","unstructured":"Saez-Llorens X, Castano E, Null D et al (1998) Safety and pharmacokinetics of an intramuscular humanized monoclonal antibody to respiratory syncytial virus in premature infants and infants with bronchopulmonary dysplasia. The MEDI-493 Study Group. Pediatr Infect Dis J 17:787\u2013791","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR154","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1097\/00007691-200206000-00020","volume":"24","author":"HL Zaaijer","year":"2002","unstructured":"Zaaijer HL, Vandenbroucke-Grauls CM, Franssen EJ (2002) Optimum dosage regimen of palivizumab? Ther Drug Monit 24:444\u2013445","journal-title":"Ther Drug Monit"},{"key":"8368_CR155","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.coviro.2012.01.008","volume":"2","author":"S van Drunen Littel-van den Hurk","year":"2012","unstructured":"van Drunen Littel-van den Hurk S, Watkiss ER (2012) Pathogenesis of respiratory syncytial virus. Curr Opin Virol 2:300\u2013305","journal-title":"Curr Opin Virol"},{"key":"8368_CR156","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/(SICI)1096-9071(200004)60:4<468::AID-JMV16>3.0.CO;2-E","volume":"60","author":"C Palomo","year":"2000","unstructured":"Palomo C, Cane PA, Melero JA (2000) Evaluation of the antibody specificities of human convalescent-phase sera against the attachment (G) protein of human respiratory syncytial virus: influence of strain variation and carbohydrate side chains. J Med Virol 60:468\u2013474","journal-title":"J Med Virol"},{"key":"8368_CR157","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1099\/0022-1317-81-4-919","volume":"81","author":"R Garcia-Beato","year":"2000","unstructured":"Garcia-Beato R, Melero JA (2000) The C-terminal third of human respiratory syncytial virus attachment (G) protein is partially resistant to protease digestion and is glycosylated in a cell-type-specific manner. J Gen Virol 81:919\u2013927","journal-title":"J Gen Virol"},{"key":"8368_CR158","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1128\/JVI.01625-07","volume":"82","author":"PL Collins","year":"2008","unstructured":"Collins PL, Graham BS (2008) Viral and host factors in human respiratory syncytial virus pathogenesis. J Virol 82:2040\u20132055","journal-title":"J Virol"},{"key":"8368_CR159","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1084\/jem.186.3.421","volume":"186","author":"A Srikiatkhachorn","year":"1997","unstructured":"Srikiatkhachorn A, Braciale TJ (1997) Virus-specific CD8+ T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection. J Exp Med 186:421\u2013432","journal-title":"J Exp Med"},{"key":"8368_CR160","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/(SICI)1096-9071(199607)49:3<161::AID-JMV2>3.0.CO;2-2","volume":"49","author":"M Jackson","year":"1996","unstructured":"Jackson M, Scott R (1996) Different patterns of cytokine induction in cultures of respiratory syncytial (RS) virus-specific human TH cell lines following stimulation with RS virus and RS virus proteins. J Med Virol 49:161\u2013169","journal-title":"J Med Virol"},{"key":"8368_CR161","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2217\/fvl.11.62","volume":"6","author":"DS McDermott","year":"2011","unstructured":"McDermott DS, Weiss KA, Knudson CJ, Varga SM (2011) Central role of dendritic cells in shaping the adaptive immune response during respiratory syncytial virus infection. Future Virol 6:963\u2013973","journal-title":"Future Virol"},{"key":"8368_CR162","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri1394","volume":"4","author":"B Adkins","year":"2004","unstructured":"Adkins B, Leclerc C, Marshall-Clarke S (2004) Neonatal adaptive immunity comes of age. Nat Rev Immunol 4:553\u2013564","journal-title":"Nat Rev Immunol"},{"key":"8368_CR163","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1046\/j.1365-2249.2002.01788.x","volume":"127","author":"J Vekemans","year":"2002","unstructured":"Vekemans J, Ota MO, Wang EC et al (2002) T cell responses to vaccines in infants: defective IFNg production after oral polio vaccination. Clin Exp Immunol 127:495\u2013498","journal-title":"Clin Exp Immunol"},{"key":"8368_CR164","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1128\/JVI.76.10.4741-4749.2002","volume":"76","author":"MC Jaimes","year":"2002","unstructured":"Jaimes MC, Rojas OL, Gonz\u00e1lez AM et al (2002) Frequencies of virus-specific CD4+ and CD8+ T lymphocytes secreting gamma interferon after acute natural rotavirus infection in children and adults. J Virol 76:4741\u20134749","journal-title":"J Virol"},{"key":"8368_CR165","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1365-2249.2005.02928.x","volume":"142","author":"C H\u00e4rtel","year":"2005","unstructured":"H\u00e4rtel C, Adam N, Strunk T, Temming P, M\u00fcller-Steinhardt M, Schultz C (2005) Cytokine responses correlate differentially with age in infancy and early childhood. Clin Exp Immunol 142:446\u2013453","journal-title":"Clin Exp Immunol"},{"key":"8368_CR166","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1046\/j.1365-2249.1999.00977.x","volume":"117","author":"M Krampera","year":"1999","unstructured":"Krampera M, Vinante F, Tavecchia L et al (1999) Progressive polarization towards a T helper\/cytotoxic type-1 cytokine pattern during age-dependent maturation of the immune response inversely correlates with CD30 cell expression and serum concentration. Clin Exp Immunol 117:291\u2013297","journal-title":"Clin Exp Immunol"},{"key":"8368_CR167","doi-asserted-by":"crossref","first-page":"4730","DOI":"10.4049\/jimmunol.160.10.4730","volume":"160","author":"SL Prescott","year":"1998","unstructured":"Prescott SL, Macaubas C, Holt BJ et al (1998) Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile. J Immunol 160:4730\u20134737","journal-title":"J Immunol"},{"key":"8368_CR168","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.jcpa.2007.04.004","volume":"137","author":"CA Siegrist","year":"2007","unstructured":"Siegrist CA (2007) The challenges of vaccine responses in early life: selected examples. J Comp Pathol 137:S4\u2013S9","journal-title":"J Comp Pathol"},{"key":"8368_CR169","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1128\/JVI.01957-06","volume":"81","author":"S Sasaki","year":"2007","unstructured":"Sasaki S, Jaimes MC, Holmes TH et al (2007) Comparison of the influenza virus-specific effector and memory B-cell responses to immunization of children and adults with live attenuated or inactivated influenza virus vaccines. J Virol 81:215\u2013228","journal-title":"J Virol"},{"key":"8368_CR170","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.humimm.2005.02.008","volume":"66","author":"JH Weitkamp","year":"2005","unstructured":"Weitkamp JH, Lafleur BJ, Greenberg HB, Crowe JE Jr (2005) Natural evolution of a human virus-specific antibody gene repertoire by somatic hypermutation requires both hotspot-directed and randomly-directed processes. Hum Immunol 66:666\u2013676","journal-title":"Hum Immunol"},{"key":"8368_CR171","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/modpathol.3800725","volume":"20","author":"JE Johnson","year":"2007","unstructured":"Johnson JE, Gonzales RA, Olson SJ, Wright PF, Graham BS (2007) The histopathology of fatal untreated human respiratory syncytial virus infection. Mod Pathol 20:108\u2013119","journal-title":"Mod Pathol"},{"key":"8368_CR172","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/(SICI)1096-9896(199706)182:2<238::AID-PATH822>3.0.CO;2-7","volume":"182","author":"C Wright","year":"1997","unstructured":"Wright C, Oliver KC, Fenwick FI, Smith NM, Toms GL (1997) A monoclonal antibody pool for routine immunohistochemical detection of human respiratory syncytial virus antigens in formalin-fixed, paraffin-embedded tissue. J Pathol 182:238\u2013244","journal-title":"J Pathol"},{"key":"8368_CR173","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1136\/thoraxjnl-2011-200131","volume":"67","author":"AM Fonceca","year":"2012","unstructured":"Fonceca AM, Flanagan BF, Trinick R, Smyth RL, McNamara PS (2012) Primary airway epithelial cultures from children are highly permissive to respiratory syncytial virus infection. Thorax 67:42\u201348","journal-title":"Thorax"},{"key":"8368_CR174","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1001\/archotol.124.7.777","volume":"124","author":"DA Tristram","year":"1998","unstructured":"Tristram DA, Hicks W Jr, Hard R (1998) Respiratory syncytial virus and human bronchial epithelium. Arch Otolaryngol Head Neck Surg 124:777\u2013783","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"8368_CR175","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.1128\/JVI.76.11.5654-5666.2002","volume":"76","author":"L Zhang","year":"2002","unstructured":"Zhang L, Peeples ME, Boucher RC, Collins PL, Pickles RJ (2002) Respiratory syncytial virus infection of human airway epithelial cells is polarized, specific to ciliated cells, and without obvious cytopathology. J Virol 76:5654\u20135666","journal-title":"J Virol"},{"key":"8368_CR176","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/01902140490252812","volume":"30","author":"TE Mellow","year":"2004","unstructured":"Mellow TE, Murphy PC, Carson JL, Noah TL, Zhang L, Pickles RJ (2004) The effect of respiratory synctial virus on chemokine release by differentiated airway epithelium. Exp Lung Res 30:43\u201357","journal-title":"Exp Lung Res"},{"key":"8368_CR177","doi-asserted-by":"crossref","first-page":"5040","DOI":"10.1073\/pnas.1110203109","volume":"109","author":"R Villenave","year":"2012","unstructured":"Villenave R, Thavagnanam S, Sarlang S et al (2012) In vitro modeling of respiratory syncytial virus infection of pediatric bronchial epithelium, the primary target of infection in vivo. Proc Natl Acad Sci U S A 109:5040\u20135045","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8368_CR178","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/nm.2444","volume":"17","author":"F Tayyari","year":"2011","unstructured":"Tayyari F, Marchant D, Moraes TJ, Duan W, Mastrangelo P, Hegele RG (2011) Identification of nucleolin as a cellular receptor for human respiratory syncytial virus. Nat Med 17:1132\u20131135","journal-title":"Nat Med"},{"key":"8368_CR179","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1128\/JVI.01740-06","volume":"81","author":"P Liu","year":"2007","unstructured":"Liu P, Jamaluddin M, Li K, Garofalo RP, Casola A, Brasier AR (2007) Retinoic acid-inducible gene I mediates early antiviral response and Toll-like receptor 3 expression in respiratory syncytial virus-infected airway epithelial cells. J Virol 81:1401\u20131411","journal-title":"J Virol"},{"key":"8368_CR180","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.virusres.2011.07.011","volume":"160","author":"T Okabayashi","year":"2011","unstructured":"Okabayashi T, Kojima T, Masaki T et al (2011) Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells. Virus Res 160:360\u2013366","journal-title":"Virus Res"},{"key":"8368_CR181","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.virusres.2012.06.003","volume":"167","author":"R Zeng","year":"2012","unstructured":"Zeng R, Cui Y, Hai Y, Liu Y (2012) Pattern recognition receptors for respiratory syncytial virus infection and design of vaccines. Virus Res 167:138\u2013145","journal-title":"Virus Res"},{"key":"8368_CR182","doi-asserted-by":"crossref","first-page":"4756","DOI":"10.1128\/JVI.72.6.4756-4764.1998","volume":"72","author":"B Olszewska-Pazdrak","year":"1998","unstructured":"Olszewska-Pazdrak B, Casola A, Saito T et al (1998) Cell-specific expression of RANTES, MCP-1, and MIP-1alpha by lower airway epithelial cells and eosinophils infected with respiratory syncytial virus. J Virol 72:4756\u20134764","journal-title":"J Virol"},{"key":"8368_CR183","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s10753-009-9128-0","volume":"32","author":"H Mochizuki","year":"2009","unstructured":"Mochizuki H, Todokoro M, Arakawa H (2009) RS virus-induced inflammation and the intracellular glutathione redox state in cultured human airway epithelial cells. Inflammation 32:252\u2013264","journal-title":"Inflammation"},{"key":"8368_CR184","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1034\/j.1399-3038.1999.101005.x","volume":"10","author":"CA Bonville","year":"1999","unstructured":"Bonville CA, Rosenberg HF, Domachowske JB (1999) Macrophage inflammatory protein-1alpha and RANTES are present in nasal secretions during ongoing upper respiratory tract infection. Pediatr Allergy Immunol 10:39\u201344","journal-title":"Pediatr Allergy Immunol"},{"key":"8368_CR185","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1086\/382958","volume":"189","author":"AL Miller","year":"2004","unstructured":"Miller AL, Bowlin TL, Lukacs NW (2004) Respiratory syncytial virus-induced chemokine production: linking viral replication to chemokine production in vitro and in vivo. J Infect Dis 189:1419\u20131430","journal-title":"J Infect Dis"},{"key":"8368_CR186","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.4049\/jimmunol.176.4.2562","volume":"176","author":"AL Miller","year":"2006","unstructured":"Miller AL, Gerard C, Schaller M, Gruber AD, Humbles AA, Lukacs NW (2006) Deletion of CCR1 attenuates pathophysiologic responses during respiratory syncytial virus infection. J Immunol 176:2562\u20132567","journal-title":"J Immunol"},{"key":"8368_CR187","doi-asserted-by":"crossref","first-page":"9790","DOI":"10.1128\/JVI.00530-07","volume":"81","author":"NA Jewell","year":"2007","unstructured":"Jewell NA, Vaghefi N, Mertz SE et al (2007) Differential type I interferon induction by respiratory syncytial virus and influenza a virus in vivo. J Virol 81:9790\u20139800","journal-title":"J Virol"},{"key":"8368_CR188","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/infdis\/175.3.497","volume":"175","author":"T Saito","year":"1997","unstructured":"Saito T, Deskin RW, Casola A et al (1997) Respiratory syncytial virus induces selective production of the chemokine RANTES by upper airway epithelial cells. J Infect Dis 175:497\u2013504","journal-title":"J Infect Dis"},{"key":"8368_CR189","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1189\/jlb.1006611","volume":"81","author":"PT Morrison","year":"2007","unstructured":"Morrison PT, Thomas LH, Sharland M, Friedland JS (2007) RSV-infected airway epithelial cells cause biphasic up-regulation of CCR1 expression on human monocytes. J Leukoc Biol 81:1487\u20131495","journal-title":"J Leukoc Biol"},{"key":"8368_CR190","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0171-2985(99)80049-7","volume":"201","author":"S Becker","year":"1999","unstructured":"Becker S, Soukup JM (1999) Airway epithelial cell-induced activation of monocytes and eosinophils in respiratory syncytial viral infection. Immunobiology 201:88\u2013106","journal-title":"Immunobiology"},{"key":"8368_CR191","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.4049\/jimmunol.147.12.4307","volume":"147","author":"S Becker","year":"1991","unstructured":"Becker S, Quay J, Soukup J (1991) Cytokine (tumor necrosis factor, IL-6, and IL-8) production by respiratory syncytial virus-infected human alveolar macrophages. J Immunol 147:4307\u20134312","journal-title":"J Immunol"},{"key":"8368_CR192","doi-asserted-by":"crossref","first-page":"L148","DOI":"10.1152\/ajplung.00065.2011","volume":"301","author":"RA Bem","year":"2011","unstructured":"Bem RA, Domachowske JB, Rosenberg HF (2011) Animal models of human respiratory syncytial virus disease. Am J Physiol Lung Cell Mol Physiol 301:L148\u2013L156","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"8368_CR193","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1378\/chest.105.6.1848","volume":"105","author":"RG Hegele","year":"1994","unstructured":"Hegele RG, Hayashi S, Bramley AM, Hogg JC (1994) Persistence of respiratory syncytial virus genome and protein after acute bronchiolitis in guinea pigs. Chest 105:1848\u20131854","journal-title":"Chest"},{"key":"8368_CR194","unstructured":"Human respiratory syncytial virus strain hRSVs\/Dibrugarh.IND\/3684.12 attachment glycoprotein (G) gene, partial cds. GenBank: KC117368.2"},{"key":"8368_CR195","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/S0264-410X(98)00379-X","volume":"17","author":"AR Woolums","year":"1999","unstructured":"Woolums AR, Singer RS, Boyle GA, Gershwin LJ (1999) Interferon gamma production during bovine respiratory syncytial virus (BRSV) infection is diminished in calves vaccinated with formalin-inactivated BRSV. Vaccine 17:1293\u20131297","journal-title":"Vaccine"},{"key":"8368_CR196","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1086\/514208","volume":"177","author":"SM van Schaik","year":"1998","unstructured":"van Schaik SM, Enhorning G, Vargas I, Welliver RC (1998) Respiratory syncytial virus affects pulmonary function in BALB\/c mice. J Infect Dis 177:269\u2013276","journal-title":"J Infect Dis"},{"key":"8368_CR197","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.4049\/jimmunol.1101789","volume":"187","author":"MM Bera","year":"2011","unstructured":"Bera MM, Lu B, Martin TR et al (2011) Th17 cytokines are critical for respiratory syncytial virus-associated airway hyperreponsiveness through regulation by complement C3a and tachykinins. J Immunol 187:4245\u20134255","journal-title":"J Immunol"},{"key":"8368_CR198","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1743-422X-2-46","volume":"2","author":"S Ch\u00e1vez-Bueno","year":"2005","unstructured":"Ch\u00e1vez-Bueno S, Mej\u00edas A, G\u00f3mez AM et al (2005) Respiratory syncytial virus-induced acute and chronic airway disease is independent of genetic background: an experimental murine model. Virol J 2:46","journal-title":"Virol J"},{"key":"8368_CR199","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1086\/386372","volume":"189","author":"HS Jafri","year":"2004","unstructured":"Jafri HS, Chavez-Bueno S, Mejias A et al (2004) Respiratory syncytial virus induces pneumonia, cytokine response, airway obstruction, and chronic inflammatory infiltrates associated with long-term airway hyperresponsiveness in mice. J Infect Dis 189:1856\u20131865","journal-title":"J Infect Dis"},{"key":"8368_CR200","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/(SICI)1096-9071(199902)57:2<186::AID-JMV17>3.0.CO;2-Q","volume":"57","author":"RS Peebles Jr","year":"1999","unstructured":"Peebles RS Jr, Sheller JR, Johnson JE, Mitchell DB, Graham BS (1999) Respiratory syncytial virus infection prolongs methacholine-induced airway hyperresponsiveness in ovalbumin-sensitized mice. J Med Virol 57:186\u2013192","journal-title":"J Med Virol"},{"key":"8368_CR201","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1006\/clim.2000.4914","volume":"97","author":"TL Noah","year":"2000","unstructured":"Noah TL, Becker S (2000) Chemokines in nasal secretions of normal adults experimentally infected with respiratory syncytial virus. Clin Immunol 97:43\u201349","journal-title":"Clin Immunol"},{"key":"8368_CR202","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.4049\/jimmunol.168.6.2944","volume":"168","author":"JE Durbin","year":"2002","unstructured":"Durbin JE, Johnson TR, Durbin RK et al (2002) The role of IFN in respiratory syncytial virus pathogenesis. J Immunol 168:2944\u20132952","journal-title":"J Immunol"},{"key":"8368_CR203","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1128\/JVI.75.2.878-890.2001","volume":"75","author":"HA Haeberle","year":"2001","unstructured":"Haeberle HA, Kuziel WA, Dieterich HJ, Casola A, Gatalica Z, Garofalo RP (2001) Inducible expression of inflammatory chemokines in respiratory syncytial virus-infected mice: role of MIP-1alpha in lung pathology. J Virol 75:878\u2013890","journal-title":"J Virol"},{"key":"8368_CR204","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.1128\/JVI.02541-07","volume":"82","author":"PK Pribul","year":"2008","unstructured":"Pribul PK, Harker J, Wang B et al (2008) Alveolar macrophages are a major determinant of early responses to viral lung infection but do not influence subsequent disease development. J Virol 82:4441\u20134448","journal-title":"J Virol"},{"key":"8368_CR205","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1002\/1521-4141(200109)31:9<2566::AID-IMMU2566>3.0.CO;2-L","volume":"31","author":"T Hussell","year":"2001","unstructured":"Hussell T, Pennycook A, Openshaw PJ (2001) Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology. Eur J Immunol 31:2566\u20132573","journal-title":"Eur J Immunol"},{"key":"8368_CR206","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.4049\/jimmunol.173.5.3408","volume":"173","author":"JA Rutigliano","year":"2004","unstructured":"Rutigliano JA, Graham BS (2004) Prolonged production of TNF-alpha exacerbates illness during respiratory syncytial virus infection. J Immunol 173:3408\u20133417","journal-title":"J Immunol"},{"key":"8368_CR207","doi-asserted-by":"crossref","first-page":"e9381","DOI":"10.1371\/journal.pone.0009381","volume":"5","author":"JS Tregoning","year":"2010","unstructured":"Tregoning JS, Pribul PK, Pennycook AM et al (2010) The chemokine MIP1alpha\/CCL3 determines pathology in primary RSV infection by regulating the balance of T cell populations in the murine lung. PLoS One 5:e9381","journal-title":"PLoS One"},{"key":"8368_CR208","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1172\/JCI5849","volume":"103","author":"AM LeVine","year":"1999","unstructured":"LeVine AM, Gwozdz J, Stark J, Bruno M, Whitsett J, Korfhagen T (1999) Surfactant protein-A enhances respiratory syncytial virus clearance in vivo. J Clin Invest 103:1015\u20131021","journal-title":"J Clin Invest"},{"key":"8368_CR209","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.jaci.2003.08.046","volume":"112","author":"JW Park","year":"2003","unstructured":"Park JW, Taube C, Yang ES et al (2003) Respiratory syncytial virus-induced airway hyperresponsiveness is independent of IL-13 compared with that induced by allergen. J Allergy Clin Immunol 112:1078\u20131087","journal-title":"J Allergy Clin Immunol"},{"key":"8368_CR210","doi-asserted-by":"crossref","first-page":"L761","DOI":"10.1152\/ajplung.00143.2004","volume":"288","author":"A Dakhama","year":"2005","unstructured":"Dakhama A, Park JW, Taube C et al (2005) Alteration of airway neuropeptide expression and development of airway hyperresponsiveness following respiratory syncytial virus infection. Am J Physiol Lung Cell Mol Physiol 288:L761\u2013L770","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"8368_CR211","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1128\/JVI.02014-09","volume":"84","author":"JA Harker","year":"2010","unstructured":"Harker JA, Godlee A, Wahlsten JL et al (2010) Interleukin 18 coexpression during respiratory syncytial virus infection results in enhanced disease mediated by natural killer cells. J Virol 84:4073\u20134082","journal-title":"J Virol"},{"key":"8368_CR212","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1086\/592714","volume":"198","author":"D Estripeaut","year":"2008","unstructured":"Estripeaut D, Torres JP, Somers CS et al (2008) Respiratory syncytial virus persistence in the lungs correlates with airway hyperreactivity in the mouse model. J Infect Dis 198:1435\u20131443","journal-title":"J Infect Dis"},{"issue":"Pt 11","key":"8368_CR213","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1099\/0022-1317-79-11-2593","volume":"79","author":"T Hussell","year":"1998","unstructured":"Hussell T, Openshaw PJ (1998) Intracellular IFN-gamma expression in natural killer cells precedes lung CD8+ T cell recruitment during respiratory syncytial virus infection. J Gen Virol 79(Pt 11):2593\u20132601","journal-title":"J Gen Virol"},{"key":"8368_CR214","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.4049\/jimmunol.1001758","volume":"185","author":"GE Kaiko","year":"2010","unstructured":"Kaiko GE, Phipps S, Angkasekwinai P, Dong C, Foster PS (2010) NK cell deficiency predisposes to viral-induced Th2-type allergic inflammation via epithelial-derived IL-25. J Immunol 185:4681\u20134690","journal-title":"J Immunol"},{"key":"8368_CR215","doi-asserted-by":"crossref","first-page":"e32371","DOI":"10.1371\/journal.pone.0032371","volume":"7","author":"J Loebbermann","year":"2012","unstructured":"Loebbermann J, Schnoeller C, Thornton H et al (2012) IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice. PLoS One 7:e32371","journal-title":"PLoS One"},{"key":"8368_CR216","doi-asserted-by":"crossref","first-page":"7234","DOI":"10.4049\/jimmunol.174.11.7234","volume":"174","author":"TR Johnson","year":"2005","unstructured":"Johnson TR, Mertz SE, Gitiban N et al (2005) Role for innate IFNs in determining respiratory syncytial virus immunopathology. J Immunol 174:7234\u20137241","journal-title":"J Immunol"},{"key":"8368_CR217","doi-asserted-by":"crossref","first-page":"8790","DOI":"10.1128\/JVI.00796-10","volume":"84","author":"DC Lee","year":"2010","unstructured":"Lee DC, Harker JA, Tregoning JS et al (2010) CD25+ natural regulatory T cells are critical in limiting innate and adaptive immunity and resolving disease following respiratory syncytial virus infection. J Virol 84:8790\u20138798","journal-title":"J Virol"},{"key":"8368_CR218","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0091-6749(03)02020-7","volume":"112","author":"MJ M\u00e4kel\u00e4","year":"2003","unstructured":"M\u00e4kel\u00e4 MJ, Tripp R, Dakhama A et al (2003) Prior airway exposure to allergen increases virus-induced airway hyperresponsiveness. J Allergy Clin Immunol 112:861\u2013869","journal-title":"J Allergy Clin Immunol"},{"key":"8368_CR219","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1172\/JCI119516","volume":"100","author":"J Schwarze","year":"1997","unstructured":"Schwarze J, Hamelmann E, Bradley KL, Takeda K, Gelfand EW (1997) Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen. J Clin Invest 100:226\u2013233","journal-title":"J Clin Invest"},{"key":"8368_CR220","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.4049\/jimmunol.162.5.2997","volume":"162","author":"J Schwarze","year":"1999","unstructured":"Schwarze J, Cieslewicz G, Hamelmann E et al (1999) IL-5 and eosinophils are essential for the development of airway hyperresponsiveness following acute respiratory syncytial virus infection. J Immunol 162:2997\u20133004","journal-title":"J Immunol"},{"key":"8368_CR221","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/cimm.2000.1730","volume":"206","author":"JB Domachowske","year":"2000","unstructured":"Domachowske JB, Bonville CA, Gao JL, Murphy PM, Easton AJ, Rosenberg HF (2000) MIP-1alpha is produced but it does not control pulmonary inflammation in response to respiratory syncytial virus infection in mice. Cell Immunol 206:1\u20136","journal-title":"Cell Immunol"},{"key":"8368_CR222","first-page":"14","volume":"62","author":"CH Johnson","year":"2012","unstructured":"Johnson CH, Miao C, Blanchard EG et al (2012) Effect of chemokine receptor CX3CR1 deficiency in a murine model of respiratory syncytial virus infection. Comp Med 62:14\u201320","journal-title":"Comp Med"},{"key":"8368_CR223","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1002\/1521-4141(200211)32:11<3276::AID-IMMU3276>3.0.CO;2-5","volume":"32","author":"KK Tekkanat","year":"2002","unstructured":"Tekkanat KK, Maassab H, Miller A, Berlin AA, Kunkel SL, Lukacs NW (2002) RANTES (CCL5) production during primary respiratory syncytial virus infection exacerbates airway disease. Eur J Immunol 32:3276\u20133284","journal-title":"Eur J Immunol"},{"key":"8368_CR224","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.4049\/jimmunol.170.6.3348","volume":"170","author":"AL Miller","year":"2003","unstructured":"Miller AL, Strieter RM, Gruber AD, Ho SB, Lukacs NW (2003) CXCR2 regulates respiratory syncytial virus-induced airway hyperreactivity and mucus overproduction. J Immunol 170:3348\u20133356","journal-title":"J Immunol"},{"key":"8368_CR225","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1172\/JCI115362","volume":"88","author":"BS Graham","year":"1991","unstructured":"Graham BS, Bunton LA, Wright PF, Karzon DT (1991) Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice. J Clin Invest 88:1026\u20131033","journal-title":"J Clin Invest"},{"key":"8368_CR226","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1365-2249.1992.tb06482.x","volume":"88","author":"WH Alwan","year":"1992","unstructured":"Alwan WH, Record FM, Openshaw PJ (1992) CD4+ T cells clear virus but augment disease in mice infected with respiratory syncytial virus. Comparison with the effects of CD8+ T cells. Clin Exp Immunol 88:527\u2013536","journal-title":"Clin Exp Immunol"},{"key":"8368_CR227","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1084\/jem.168.3.1163","volume":"168","author":"MJ Cannon","year":"1988","unstructured":"Cannon MJ, Openshaw PJ, Askonas BA (1988) Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus. J Exp Med 168:1163\u20131168","journal-title":"J Exp Med"},{"key":"8368_CR228","doi-asserted-by":"crossref","first-page":"9918","DOI":"10.1128\/JVI.75.20.9918-9924.2001","volume":"75","author":"S Aung","year":"2001","unstructured":"Aung S, Rutigliano JA, Graham BS (2001) Alternative mechanisms of respiratory syncytial virus clearance in perforin knockout mice lead to enhanced disease. J Virol 75:9918\u20139924","journal-title":"J Virol"},{"key":"8368_CR229","doi-asserted-by":"crossref","first-page":"6263","DOI":"10.4049\/jimmunol.177.9.6263","volume":"177","author":"H Wang","year":"2006","unstructured":"Wang H, Peters N, Schwarze J (2006) Plasmacytoid dendritic cells limit viral replication, pulmonary inflammation, and airway hyperresponsiveness in respiratory syncytial virus infection. J Immunol 177:6263\u20136270","journal-title":"J Immunol"},{"key":"8368_CR230","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.4049\/jimmunol.0802262","volume":"182","author":"A Guerrero-Plata","year":"2009","unstructured":"Guerrero-Plata A, Kolli D, Hong C, Casola A, Garofalo RP (2009) Subversion of pulmonary dendritic cell function by paramyxovirus infections. J Immunol 182:3072\u20133083","journal-title":"J Immunol"},{"key":"8368_CR231","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1084\/jem.20052359","volume":"203","author":"JJ Smit","year":"2006","unstructured":"Smit JJ, Rudd BD, Lukacs NW (2006) Plasmacytoid dendritic cells inhibit pulmonary immunopathology and promote clearance of respiratory syncytial virus. J Exp Med 203:1153\u20131159","journal-title":"J Exp Med"},{"key":"8368_CR232","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jaci.2003.10.057","volume":"113","author":"M Beyer","year":"2004","unstructured":"Beyer M, Bartz H, Horner K, Doths S, Koerner-Rettberg C, Schwarze J (2004) Sustained increases in numbers of pulmonary dendritic cells after respiratory syncytial virus infection. J Allergy Clin Immunol 113:127\u2013133","journal-title":"J Allergy Clin Immunol"},{"key":"8368_CR233","doi-asserted-by":"crossref","first-page":"14992","DOI":"10.1128\/JVI.79.23.14992-14997.2005","volume":"79","author":"A Guerrero-Plata","year":"2005","unstructured":"Guerrero-Plata A, Casola A, Garofalo RP (2005) Human metapneumovirus induces a profile of lung cytokines distinct from that of respiratory syncytial virus. J Virol 79:14992\u201314997","journal-title":"J Virol"},{"key":"8368_CR234","doi-asserted-by":"crossref","first-page":"10190","DOI":"10.1128\/JVI.79.16.10190-10199.2005","volume":"79","author":"A Guerrero-Plata","year":"2005","unstructured":"Guerrero-Plata A, Baron S, Poast JS, Adegboyega PA, Casola A, Garofalo RP (2005) Activity and regulation of alpha interferon in respiratory syncytial virus and human metapneumovirus experimental infections. J Virol 79:10190\u201310199","journal-title":"J Virol"},{"key":"8368_CR235","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/1096-9071(200010)62:2<257::AID-JMV19>3.0.CO;2-M","volume":"62","author":"SM van Schaik","year":"2000","unstructured":"van Schaik SM, Obot N, Enhorning G et al (2000) Role of interferon gamma in the pathogenesis of primary respiratory syncytial virus infection in BALB\/c mice. J Med Virol 62:257\u2013266","journal-title":"J Med Virol"},{"key":"8368_CR236","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/1096-9071(20000201)63:2<178::AID-JMV1013>3.0.CO;2-O","volume":"63","author":"RS Peebles Jr","year":"2001","unstructured":"Peebles RS Jr, Sheller JR, Collins RD et al (2001) Respiratory syncytial virus infection does not increase allergen-induced type 2 cytokine production, yet increases airway hyperresponsiveness in mice. J Med Virol 63:178\u2013188","journal-title":"J Med Virol"},{"key":"8368_CR237","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1164\/rccm.200612-1890OC","volume":"177","author":"YM Lee","year":"2008","unstructured":"Lee YM, Miyahara N, Takeda K et al (2008) IFN-gamma production during initial infection determines the outcome of reinfection with respiratory syncytial virus. Am J Respir Crit Care Med 177:208\u2013218","journal-title":"Am J Respir Crit Care Med"},{"key":"8368_CR238","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0002-9440(10)61734-8","volume":"159","author":"KK Tekkanat","year":"2001","unstructured":"Tekkanat KK, Maassab H, Berlin AA et al (2001) Role of interleukin-12 and stat-4 in the regulation of airway inflammation and hyperreactivity in respiratory syncytial virus infection. Am J Pathol 159:631\u2013638","journal-title":"Am J Pathol"},{"key":"8368_CR239","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.4049\/jimmunol.162.7.4207","volume":"162","author":"J Schwarze","year":"1999","unstructured":"Schwarze J, Cieslewicz G, Joetham A, Ikemura T, Hamelmann E, Gelfand EW (1999) CD8 T cells are essential in the development of respiratory syncytial virus-induced lung eosinophilia and airway hyperresponsiveness. J Immunol 162:4207\u20134211","journal-title":"J Immunol"},{"issue":"Pt 7","key":"8368_CR240","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1099\/0022-1317-79-7-1751","volume":"79","author":"LC Spender","year":"1998","unstructured":"Spender LC, Hussell T, Openshaw PJ (1998) Abundant IFN-gamma production by local T cells in respiratory syncytial virus-induced eosinophilic lung disease. J Gen Virol 79(Pt 7):1751\u20131758","journal-title":"J Gen Virol"},{"key":"8368_CR241","doi-asserted-by":"crossref","first-page":"6583","DOI":"10.4049\/jimmunol.164.12.6583","volume":"164","author":"H Matsuse","year":"2000","unstructured":"Matsuse H, Behera AK, Kumar M, Rabb H, Lockey RF, Mohapatra SS (2000) Recurrent respiratory syncytial virus infections in allergen-sensitized mice lead to persistent airway inflammation and hyperresponsiveness. J Immunol 164:6583\u20136592","journal-title":"J Immunol"},{"key":"8368_CR242","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.4049\/jimmunol.173.6.4040","volume":"173","author":"SZ Wang","year":"2004","unstructured":"Wang SZ, Bao YX, Rosenberger CL, Tesfaigzi Y, Stark JM, Harrod KS (2004) IL-12p40 and IL-18 modulate inflammatory and immune responses to respiratory syncytial virus infection. J Immunol 173:4040\u20134049","journal-title":"J Immunol"},{"key":"8368_CR243","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1002\/eji.200324449","volume":"34","author":"S Ehl","year":"2004","unstructured":"Ehl S, Bischoff R, Ostler T et al (2004) The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus. Eur J Immunol 34:1146\u20131153","journal-title":"Eur J Immunol"},{"key":"8368_CR244","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.4049\/jimmunol.175.3.1876","volume":"175","author":"A Dakhama","year":"2005","unstructured":"Dakhama A, Park JW, Taube C et al (2005) The enhancement or prevention of airway hyperresponsiveness during reinfection with respiratory syncytial virus is critically dependent on the age at first infection and IL-13 production. J Immunol 175:1876\u20131883","journal-title":"J Immunol"},{"key":"8368_CR245","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.0105-2896.2004.00215.x","volume":"202","author":"M Wills-Karp","year":"2004","unstructured":"Wills-Karp M (2004) Interleukin-13 in asthma pathogenesis. Immunol Rev 202:175\u2013190","journal-title":"Immunol Rev"},{"key":"8368_CR246","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.4049\/jimmunol.166.5.3542","volume":"166","author":"KK Tekkanat","year":"2001","unstructured":"Tekkanat KK, Maassab HF, Cho DS et al (2001) IL-13-induced airway hyperreactivity during respiratory syncytial virus infection is STAT6 dependent. J Immunol 166:3542\u20133548","journal-title":"J Immunol"},{"key":"8368_CR247","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1086\/324429","volume":"184","author":"RS Peebles Jr","year":"2001","unstructured":"Peebles RS Jr, Hashimoto K, Collins RD et al (2001) Immune interaction between respiratory syncytial virus infection and allergen sensitization critically depends on timing of challenges. J Infect Dis 184:1374\u20131379","journal-title":"J Infect Dis"},{"key":"8368_CR248","doi-asserted-by":"crossref","first-page":"e1002173","DOI":"10.1371\/journal.ppat.1002173","volume":"7","author":"J Sun","year":"2011","unstructured":"Sun J, Cardani A, Sharma AK et al (2011) Autocrine regulation of pulmonary inflammation by effector T-cell derived IL-10 during infection with respiratory syncytial virus. PLoS Pathog 7:e1002173","journal-title":"PLoS Pathog"},{"key":"8368_CR249","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1046\/j.1365-2567.2001.01318.x","volume":"104","author":"Y Ruan","year":"2001","unstructured":"Ruan Y, Okamoto Y, Matsuzaki Z et al (2001) Suppressive effect of locally produced interleukin-10 on respiratory syncytial virus infection. Immunology 104:355\u2013360","journal-title":"Immunology"},{"key":"8368_CR250","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1365-2567.2011.03465.x","volume":"134","author":"R Pappu","year":"2011","unstructured":"Pappu R, Ramirez-Carrozzi V, Sambandam A (2011) The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases. Immunology 134:8\u201316","journal-title":"Immunology"},{"key":"8368_CR251","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ajpath.2011.03.003","volume":"179","author":"S Mukherjee","year":"2011","unstructured":"Mukherjee S, Lindell DM, Berlin AA et al (2011) IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease. Am J Pathol 179:248\u2013258","journal-title":"Am J Pathol"},{"key":"8368_CR252","doi-asserted-by":"crossref","first-page":"6873","DOI":"10.1128\/JVI.76.14.6873-6881.2002","volume":"76","author":"LM Haynes","year":"2002","unstructured":"Haynes LM, Tonkin J, Anderson LJ, Tripp RA (2002) Neutralizing anti-F glycoprotein and anti-substance P antibody treatment effectively reduces infection and inflammation associated with respiratory syncytial virus infection. J Virol 76:6873\u20136881","journal-title":"J Virol"},{"key":"8368_CR253","first-page":"S66","volume":"22","author":"G Piedimonte","year":"2003","unstructured":"Piedimonte G (2003) Contribution of neuroimmune mechanisms to airway inflammation and remodeling during and after respiratory syncytial virus infection. Pediatr Infect Dis J 22:S66\u2013S74, discussion S74-65","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR254","doi-asserted-by":"crossref","first-page":"e36812","DOI":"10.1371\/journal.pone.0036812","volume":"7","author":"T Kamphuis","year":"2012","unstructured":"Kamphuis T, Meijerhof T, Stegmann T, Lederhofer J, Wilschut J, de Haan A (2012) Immunogenicity and protective capacity of a virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice. PLoS One 7:e36812","journal-title":"PLoS One"},{"key":"8368_CR255","doi-asserted-by":"crossref","first-page":"11303","DOI":"10.1128\/JVI.77.21.11303-11311.2003","volume":"77","author":"R Singleton","year":"2003","unstructured":"Singleton R, Etchart N, Hou S, Hyland L (2003) Inability to evoke a long-lasting protective immune response to respiratory syncytial virus infection in mice correlates with ineffective nasal antibody responses. J Virol 77:11303\u201311311","journal-title":"J Virol"},{"key":"8368_CR256","doi-asserted-by":"crossref","first-page":"4936","DOI":"10.1128\/jvi.65.9.4936-4942.1991","volume":"65","author":"BS Graham","year":"1991","unstructured":"Graham BS, Bunton LA, Rowland J, Wright PF, Karzon DT (1991) Respiratory syncytial virus infection in anti-mu-treated mice. J Virol 65:4936\u20134942","journal-title":"J Virol"},{"key":"8368_CR257","doi-asserted-by":"crossref","first-page":"3910","DOI":"10.4049\/jimmunol.167.7.3910","volume":"167","author":"JE Crowe Jr","year":"2001","unstructured":"Crowe JE Jr, Firestone CY, Murphy BR (2001) Passively acquired antibodies suppress humoral but not cell-mediated immunity in mice immunized with live attenuated respiratory syncytial virus vaccines. J Immunol 167:3910\u20133918","journal-title":"J Immunol"},{"key":"8368_CR258","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nm.1894","volume":"15","author":"MF Delgado","year":"2009","unstructured":"Delgado MF, Coviello S, Monsalvo AC et al (2009) Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease. Nat Med 15:34\u201341","journal-title":"Nat Med"},{"key":"8368_CR259","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1164\/rccm.200311-1610OC","volume":"170","author":"A Dakhama","year":"2004","unstructured":"Dakhama A, Park JW, Taube C et al (2004) The role of virus-specific immunoglobulin E in airway hyperresponsiveness. Am J Respir Crit Care Med 170:952\u2013959","journal-title":"Am J Respir Crit Care Med"},{"key":"8368_CR260","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2460\/ajvr.2000.61.291","volume":"61","author":"LJ Gershwin","year":"2000","unstructured":"Gershwin LJ, Gunther RA, Anderson ML et al (2000) Bovine respiratory syncytial virus-specific IgE is associated with interleukin-2 and -4, and interferon-gamma expression in pulmonary lymph of experimentally infected calves. Am J Vet Res 61:291\u2013298","journal-title":"Am J Vet Res"},{"key":"8368_CR261","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1183\/09031936.97.10010020","volume":"10","author":"A Dakhama","year":"1997","unstructured":"Dakhama A, Vitalis TZ, Hegele RG (1997) Persistence of respiratory syncytial virus (RSV) infection and development of RSV-specific IgG1 response in a guinea-pig model of acute bronchiolitis. Eur Respir J 10:20\u201326","journal-title":"Eur Respir J"},{"issue":"138\u2013145","key":"8368_CR262","first-page":"e135","volume":"123","author":"A Dakhama","year":"2009","unstructured":"Dakhama A, Lee YM, Ohnishi H et al (2009) Virus-specific IgE enhances airway responsiveness on reinfection with respiratory syncytial virus in newborn mice. J Allergy Clin Immunol 123(138\u2013145):e135","journal-title":"J Allergy Clin Immunol"},{"key":"8368_CR263","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1086\/428855","volume":"191","author":"PS McNamara","year":"2005","unstructured":"McNamara PS, Flanagan BF, Hart CA, Smyth RL (2005) Production of chemokines in the lungs of infants with severe respiratory syncytial virus bronchiolitis. J Infect Dis 191:1225\u20131232","journal-title":"J Infect Dis"},{"key":"8368_CR264","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1164\/ajrccm.159.6.9805083","volume":"159","author":"AM Harrison","year":"1999","unstructured":"Harrison AM, Bonville CA, Rosenberg HF, Domachowske JB (1999) Respiratory syncytical virus-induced chemokine expression in the lower airways: eosinophil recruitment and degranulation. Am J Respir Crit Care Med 159:1918\u20131924","journal-title":"Am J Respir Crit Care Med"},{"key":"8368_CR265","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1086\/593018","volume":"198","author":"MA Gill","year":"2008","unstructured":"Gill MA, Long K, Kwon T et al (2008) Differential recruitment of dendritic cells and monocytes to respiratory mucosal sites in children with influenza virus or respiratory syncytial virus infection. J Infect Dis 198:1667\u20131676","journal-title":"J Infect Dis"},{"key":"8368_CR266","first-page":"162","volume":"18","author":"JF Bermejo-Martin","year":"2007","unstructured":"Bermejo-Martin JF, Garcia-Arevalo MC, De Lejarazu RO et al (2007) Predominance of Th2 cytokines, CXC chemokines and innate immunity mediators at the mucosal level during severe respiratory syncytial virus infection in children. Eur Cytokine Netw 18:162\u2013167","journal-title":"Eur Cytokine Netw"},{"key":"8368_CR267","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1086\/322788","volume":"184","author":"RP Garofalo","year":"2001","unstructured":"Garofalo RP, Patti J, Hintz KA, Hill V, Ogra PL, Welliver RC (2001) Macrophage inflammatory protein-1alpha (not T helper type 2 cytokines) is associated with severe forms of respiratory syncytial virus bronchiolitis. J Infect Dis 184:393\u2013399","journal-title":"J Infect Dis"},{"key":"8368_CR268","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/jmv.20268","volume":"75","author":"RP Garofalo","year":"2005","unstructured":"Garofalo RP, Hintz KH, Hill V, Patti J, Ogra PL, Welliver RC Sr (2005) A comparison of epidemiologic and immunologic features of bronchiolitis caused by influenza virus and respiratory syncytial virus. J Med Virol 75:282\u2013289","journal-title":"J Med Virol"},{"key":"8368_CR269","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/00006454-199902000-00007","volume":"18","author":"P Sheeran","year":"1999","unstructured":"Sheeran P, Jafri H, Carubelli C et al (1999) Elevated cytokine concentrations in the nasopharyngeal and tracheal secretions of children with respiratory syncytial virus disease. Pediatr Infect Dis J 18:115\u2013122","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR270","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1034\/j.1399-3003.1999.14a23.x","volume":"14","author":"M Abu-Harb","year":"1999","unstructured":"Abu-Harb M, Bell F, Finn A et al (1999) IL-8 and neutrophil elastase levels in the respiratory tract of infants with RSV bronchiolitis. Eur Respir J 14:139\u2013143","journal-title":"Eur Respir J"},{"key":"8368_CR271","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1034\/j.1399-3038.2002.01093.x","volume":"13","author":"JE Gern","year":"2002","unstructured":"Gern JE, Martin MS, Anklam KA et al (2002) Relationships among specific viral pathogens, virus-induced interleukin-8, and respiratory symptoms in infancy. Pediatr Allergy Immunol 13:386\u2013393","journal-title":"Pediatr Allergy Immunol"},{"key":"8368_CR272","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2332\/allergolint.O-06-454","volume":"56","author":"H Murai","year":"2007","unstructured":"Murai H, Terada A, Mizuno M et al (2007) IL-10 and RANTES are elevated in nasopharyngeal secretions of children with respiratory syncytial virus infection. Allergol Int 56:157\u2013163","journal-title":"Allergol Int"},{"key":"8368_CR273","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1164\/rccm.201002-0221OC","volume":"182","author":"JP DeVincenzo","year":"2010","unstructured":"DeVincenzo JP, Wilkinson T, Vaishnaw A et al (2010) Viral load drives disease in humans experimentally infected with respiratory syncytial virus. Am J Respir Crit Care Med 182:1305\u20131314","journal-title":"Am J Respir Crit Care Med"},{"key":"8368_CR274","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/INF.0b013e31822dc8c1","volume":"31","author":"C Garcia","year":"2012","unstructured":"Garcia C, Soriano-Fallas A, Lozano J et al (2012) Decreased innate immune cytokine responses correlate with disease severity in children with respiratory syncytial virus and human rhinovirus bronchiolitis. Pediatr Infect Dis J 31:86\u201389","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR275","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1086\/515575","volume":"195","author":"BL Bennett","year":"2007","unstructured":"Bennett BL, Garofalo RP, Cron SG et al (2007) Immunopathogenesis of respiratory syncytial virus bronchiolitis. J Infect Dis 195:1532\u20131540","journal-title":"J Infect Dis"},{"key":"8368_CR276","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1136\/adc.88.10.922","volume":"88","author":"PS McNamara","year":"2003","unstructured":"McNamara PS, Ritson P, Selby A, Hart CA, Smyth RL (2003) Bronchoalveolar lavage cellularity in infants with severe respiratory syncytial virus bronchiolitis. Arch Dis Child 88:922\u2013926","journal-title":"Arch Dis Child"},{"key":"8368_CR277","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1128\/cdli.2.3.322-324.1995","volume":"2","author":"K Matsuda","year":"1995","unstructured":"Matsuda K, Tsutsumi H, Okamoto Y, Chiba C (1995) Development of interleukin 6 and tumor necrosis factor alpha activity in nasopharyngeal secretions of infants and children during infection with respiratory syncytial virus. Clin Diagn Lab Immunol 2:322\u2013324","journal-title":"Clin Diagn Lab Immunol"},{"key":"8368_CR278","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/jmv.10482","volume":"71","author":"IJ van Benten","year":"2003","unstructured":"van Benten IJ, van Drunen CM, Koopman LP et al (2003) RSV-induced bronchiolitis but not upper respiratory tract infection is accompanied by an increased nasal IL-18 response. J Med Virol 71:290\u2013297","journal-title":"J Med Virol"},{"key":"8368_CR279","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1590\/S1806-37132010000100011","volume":"36","author":"RA Vieira","year":"2010","unstructured":"Vieira RA, Diniz EM, Ceccon ME (2010) Correlation between inflammatory mediators in the nasopharyngeal secretion and in the serum of children with lower respiratory tract infection caused by respiratory syncytial virus and disease severity. J Bras Pneumol 36:59\u201366","journal-title":"J Bras Pneumol"},{"key":"8368_CR280","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/1096-9071(200010)62:2<267::AID-JMV20>3.0.CO;2-8","volume":"62","author":"AH Brandenburg","year":"2000","unstructured":"Brandenburg AH, Kleinjan A, van Het Land B et al (2000) Type 1-like immune response is found in children with respiratory syncytial virus infection regardless of clinical severity. J Med Virol 62:267\u2013277","journal-title":"J Med Virol"},{"key":"8368_CR281","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1136\/adc.71.5.428","volume":"71","author":"ML Everard","year":"1994","unstructured":"Everard ML, Swarbrick A, Wrightham M et al (1994) Analysis of cells obtained by bronchial lavage of infants with respiratory syncytial virus infection. Arch Dis Child 71:428\u2013432","journal-title":"Arch Dis Child"},{"key":"8368_CR282","doi-asserted-by":"crossref","first-page":"8410","DOI":"10.4049\/jimmunol.179.12.8410","volume":"179","author":"J Heidema","year":"2007","unstructured":"Heidema J, Lukens MV, van Maren WW et al (2007) CD8+ T cell responses in bronchoalveolar lavage fluid and peripheral blood mononuclear cells of infants with severe primary respiratory syncytial virus infections. J Immunol 179:8410\u20138417","journal-title":"J Immunol"},{"key":"8368_CR283","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1067\/mai.2003.1618","volume":"112","author":"CK Kim","year":"2003","unstructured":"Kim CK, Kim SW, Park CS, Kim BI, Kang H, Koh YY (2003) Bronchoalveolar lavage cytokine profiles in acute asthma and acute bronchiolitis. J Allergy Clin Immunol 112:64\u201371","journal-title":"J Allergy Clin Immunol"},{"key":"8368_CR284","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1651-2227.2006.tb02265.x","volume":"95","author":"CK Kim","year":"2006","unstructured":"Kim CK, Koh JY, Han TH, Kim do K, Kim BI, Koh YY (2006) Increased levels of BAL cysteinyl leukotrienes in acute [corrected] RSV bronchiolitis. Acta Paediatr 95:479\u2013485","journal-title":"Acta Paediatr"},{"key":"8368_CR285","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1203\/PDR.0b013e31816fdc32","volume":"63","author":"RA Bem","year":"2008","unstructured":"Bem RA, Bos AP, Bots M et al (2008) Activation of the granzyme pathway in children with severe respiratory syncytial virus infection. Pediatr Res 63:650\u2013655","journal-title":"Pediatr Res"},{"key":"8368_CR286","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1046\/j.1440-1754.2001.00618.x","volume":"37","author":"PK Smith","year":"2001","unstructured":"Smith PK, Wang SZ, Dowling KD, Forsyth KD (2001) Leucocyte populations in respiratory syncytial virus-induced bronchiolitis. J Paediatr Child Health 37:146\u2013151","journal-title":"J Paediatr Child Health"},{"key":"8368_CR287","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1086\/428589","volume":"191","author":"MA Gill","year":"2005","unstructured":"Gill MA, Palucka AK, Barton T et al (2005) Mobilization of plasmacytoid and myeloid dendritic cells to mucosal sites in children with respiratory syncytial virus and other viral respiratory infections. J Infect Dis 191:1105\u20131115","journal-title":"J Infect Dis"},{"key":"8368_CR288","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/jcp.23.1.7","volume":"23","author":"W Aherne","year":"1970","unstructured":"Aherne W, Bird T, Court SD, Gardner PS, McQuillin J (1970) Pathological changes in virus infections of the lower respiratory tract in children. J Clin Pathol 23:7\u201318","journal-title":"J Clin Pathol"},{"key":"8368_CR289","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1086\/593173","volume":"198","author":"JL Reed","year":"2008","unstructured":"Reed JL, Brewah YA, Delaney T et al (2008) Macrophage impairment underlies airway occlusion in primary respiratory syncytial virus bronchiolitis. J Infect Dis 198:1783\u20131793","journal-title":"J Infect Dis"},{"key":"8368_CR290","doi-asserted-by":"crossref","first-page":"S92","DOI":"10.1097\/INF.0b013e318168b706","volume":"27","author":"TP Welliver","year":"2008","unstructured":"Welliver TP, Reed JL, Welliver RC Sr (2008) Respiratory syncytial virus and influenza virus infections: observations from tissues of fatal infant cases. Pediatr Infect Dis J 27:S92\u2013S96","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR291","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1086\/512615","volume":"195","author":"TP Welliver","year":"2007","unstructured":"Welliver TP, Garofalo RP, Hosakote Y et al (2007) Severe human lower respiratory tract illness caused by respiratory syncytial virus and influenza virus is characterized by the absence of pulmonary cytotoxic lymphocyte responses. J Infect Dis 195:1126\u20131136","journal-title":"J Infect Dis"},{"key":"8368_CR292","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1093\/oxfordjournals.aje.a120955","volume":"89","author":"HW Kim","year":"1969","unstructured":"Kim HW, Canchola JG, Brandt CD et al (1969) Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am J Epidemiol 89:422\u2013434","journal-title":"Am J Epidemiol"},{"key":"8368_CR293","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1099\/0022-1317-82-12-2881","volume":"82","author":"GA Prince","year":"2001","unstructured":"Prince GA, Curtis SJ, Yim KC, Porter DD (2001) Vaccine-enhanced respiratory syncytial virus disease in cotton rats following immunization with Lot 100 or a newly prepared reference vaccine. J Gen Virol 82:2881\u20132888","journal-title":"J Gen Virol"},{"key":"8368_CR294","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1128\/JVI.01807-09","volume":"84","author":"MV Lukens","year":"2010","unstructured":"Lukens MV, van de Pol AC, Coenjaerts FE et al (2010) A systemic neutrophil response precedes robust CD8+ T-cell activation during natural respiratory syncytial virus infection in infants. J Virol 84:2374\u20132383","journal-title":"J Virol"},{"key":"8368_CR295","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/jmv.1890280304","volume":"28","author":"Y Chiba","year":"1989","unstructured":"Chiba Y, Higashidate Y, Suga K, Honjo K, Tsutsumi H, Ogra PL (1989) Development of cell-mediated cytotoxic immunity to respiratory syncytial virus in human infants following naturally acquired infection. J Med Virol 28:133\u2013139","journal-title":"J Med Virol"},{"key":"8368_CR296","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1365-2249.2004.02504.x","volume":"137","author":"JH Aberle","year":"2004","unstructured":"Aberle JH, Aberle SW, Rebhandl W, Pracher E, Kundi M, Popow-Kraupp T (2004) Decreased interferon-gamma response in respiratory syncytial virus compared to other respiratory viral infections in infants. Clin Exp Immunol 137:146\u2013150","journal-title":"Clin Exp Immunol"},{"key":"8368_CR297","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1164\/ajrccm.156.1.9611050","volume":"156","author":"M Rom\u00e1n","year":"1997","unstructured":"Rom\u00e1n M, Calhoun WJ, Hinton KL et al (1997) Respiratory syncytial virus infection in infants is associated with predominant Th-2-like response. Am J Respir Crit Care Med 156:190\u2013195","journal-title":"Am J Respir Crit Care Med"},{"key":"8368_CR298","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1046\/j.1365-2249.2000.01297.x","volume":"121","author":"K Bendelja","year":"2000","unstructured":"Bendelja K, Gagro A, Bace A et al (2000) Predominant type-2 response in infants with respiratory syncytial virus (RSV) infection demonstrated by cytokine flow cytometry. Clin Exp Immunol 121:332\u2013338","journal-title":"Clin Exp Immunol"},{"key":"8368_CR299","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1086\/340505","volume":"185","author":"RA Tripp","year":"2002","unstructured":"Tripp RA, Moore D, Barskey A IV et al (2002) Peripheral blood mononuclear cells from infants hospitalized because of respiratory syncytial virus infection express T helper-1 and T helper-2 cytokines and CC chemokine messenger RNA. J Infect Dis 185:1388\u20131394","journal-title":"J Infect Dis"},{"key":"8368_CR300","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1086\/518249","volume":"195","author":"FE Lee","year":"2007","unstructured":"Lee FE, Walsh EE, Falsey AR et al (2007) Human infant respiratory syncytial virus (RSV)-specific type 1 and 2 cytokine responses ex vivo during primary RSV infection. J Infect Dis 195:1779\u20131788","journal-title":"J Infect Dis"},{"key":"8368_CR301","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.4049\/jimmunol.176.10.5848","volume":"176","author":"RN Douville","year":"2006","unstructured":"Douville RN, Bastien N, Li Y, Pochard P, Simons FE, HayGlass KT (2006) Human metapneumovirus elicits weak IFN-gamma memory responses compared with respiratory syncytial virus. J Immunol 176:5848\u20135855","journal-title":"J Immunol"},{"key":"8368_CR302","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0022-3476(98)70234-3","volume":"133","author":"DR O\u2019Donnell","year":"1998","unstructured":"O\u2019Donnell DR, McGarvey MJ, Tully JM, Balfour-Lynn IM, Openshaw PJ (1998) Respiratory syncytial virus RNA in cells from the peripheral blood during acute infection. J Pediatr 133:272\u2013274","journal-title":"J Pediatr"},{"key":"8368_CR303","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/infdis\/jir280","volume":"204","author":"CP Halfhide","year":"2011","unstructured":"Halfhide CP, Flanagan BF, Brearey SP et al (2011) Respiratory syncytial virus binds and undergoes transcription in neutrophils from the blood and airways of infants with severe bronchiolitis. J Infect Dis 204:451\u2013458","journal-title":"J Infect Dis"},{"key":"8368_CR304","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.4049\/jimmunol.181.8.5551","volume":"181","author":"J Heidema","year":"2008","unstructured":"Heidema J, Rossen JW, Lukens MV et al (2008) Dynamics of human respiratory virus-specific CD8+ T cell responses in blood and airways during episodes of common cold. J Immunol 181:5551\u20135559","journal-title":"J Immunol"},{"key":"8368_CR305","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00408-011-9349-5","volume":"190","author":"CK Kim","year":"2012","unstructured":"Kim CK, Callaway Z, Koh YY, Kim SH, Fujisawa T (2012) Airway IFN-gamma production during RSV bronchiolitis is associated with eosinophilic inflammation. Lung 190:183\u2013188","journal-title":"Lung"},{"key":"8368_CR306","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.jaci.2005.07.012","volume":"116","author":"S Kristjansson","year":"2005","unstructured":"Kristjansson S, Bjarnarson SP, Wennergren G et al (2005) Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response. J Allergy Clin Immunol 116:805\u2013811","journal-title":"J Allergy Clin Immunol"},{"key":"8368_CR307","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/jmv.20089","volume":"73","author":"RP Garofalo","year":"2004","unstructured":"Garofalo RP, Hintz KH, Hill V, Ogra PL, Welliver RC Sr (2004) Production of interferon gamma in respiratory syncytial virus infection of humans is not associated with interleukins 12 and 18. J Med Virol 73:289\u2013294","journal-title":"J Med Virol"},{"key":"8368_CR308","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0091-6749(99)70235-6","volume":"103","author":"SM van Schaik","year":"1999","unstructured":"van Schaik SM, Tristram DA, Nagpal IS, Hintz KM, Welliver RC 2nd, Welliver RC (1999) Increased production of IFN-gamma and cysteinyl leukotrienes in virus-induced wheezing. J Allergy Clin Immunol 103:630\u2013636","journal-title":"J Allergy Clin Immunol"},{"key":"8368_CR309","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1086\/322035","volume":"184","author":"L Bont","year":"2001","unstructured":"Bont L, Heijnen CJ, Kavelaars A et al (2001) Local interferon-gamma levels during respiratory syncytial virus lower respiratory tract infection are associated with disease severity. J Infect Dis 184:355\u2013358","journal-title":"J Infect Dis"},{"key":"8368_CR310","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/ppul.10101","volume":"33","author":"KJ Mobbs","year":"2002","unstructured":"Mobbs KJ, Smyth RL, O\u2019Hea U, Ashby D, Ritson P, Hart CA (2002) Cytokines in severe respiratory syncytial virus bronchiolitis. Pediatr Pulmonol 33:449\u2013452","journal-title":"Pediatr Pulmonol"},{"key":"8368_CR311","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1046\/j.1365-2249.2002.01851.x","volume":"128","author":"RH Buck","year":"2002","unstructured":"Buck RH, Cordle CT, Thomas DJ, Winship TR, Schaller JP, Dugle JE (2002) Longitudinal study of intracellular T cell cytokine production in infants compared to adults. Clin Exp Immunol 128:490\u2013497, Erratum in: Clin Exp Immunol 2002;2129(2003):2571","journal-title":"Clin Exp Immunol"},{"key":"8368_CR312","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1189\/jlb.0705396","volume":"79","author":"A Motegi","year":"2006","unstructured":"Motegi A, Kinoshita M, Sato K et al (2006) An in vitro Shwartzman reaction-like response is augmented age-dependently in human peripheral blood mononuclear cells. J Leukoc Biol 79:463\u2013472","journal-title":"J Leukoc Biol"},{"key":"8368_CR313","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1203\/PDR.0b013e3181568105","volume":"62","author":"ST Yerkovich","year":"2007","unstructured":"Yerkovich ST, Wikstr\u00f6m ME, Suriyaarachchi D, Prescott SL, Upham JW, Holt PG (2007) Postnatal development of monocyte cytokine responses to bacterial lipopolysaccharide. Pediatr Res 62:547\u2013552","journal-title":"Pediatr Res"},{"key":"8368_CR314","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1084\/jem.20020943","volume":"196","author":"FJ Culley","year":"2002","unstructured":"Culley FJ, Pollott J, Openshaw PJ (2002) Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood. J Exp Med 196:1381\u20131386","journal-title":"J Exp Med"},{"key":"8368_CR315","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S1081-1206(10)61307-5","volume":"94","author":"HL Chung","year":"2005","unstructured":"Chung HL, Kim WT, Kim JK et al (2005) Relationship between atopic status and nasal interleukin 10 and 11 levels in infants with respiratory syncytial virus bronchiolitis. Ann Allergy Asthma Immunol 94:267\u2013272","journal-title":"Ann Allergy Asthma Immunol"},{"key":"8368_CR316","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1046\/j.1365-2249.2003.02039.x","volume":"131","author":"P Joshi","year":"2003","unstructured":"Joshi P, Shaw A, Kakakios A, Isaacs D (2003) Interferon-gamma levels in nasopharyngeal secretions of infants with respiratory syncytial virus and other respiratory viral infections. Clin Exp Immunol 131:143\u2013147","journal-title":"Clin Exp Immunol"},{"key":"8368_CR317","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1365-2222.2004.1918.x","volume":"34","author":"D Dimova-Yaneva","year":"2004","unstructured":"Dimova-Yaneva D, Russell D, Main M, Brooker RJ, Helms PJ (2004) Eosinophil activation and cysteinyl leukotriene production in infants with respiratory syncytial virus bronchiolitis. Clin Exp Allergy 34:555\u2013558","journal-title":"Clin Exp Allergy"},{"key":"8368_CR318","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0022-3476(05)80592-X","volume":"120","author":"R Garofalo","year":"1992","unstructured":"Garofalo R, Kimpen JL, Welliver RC, Ogra PL (1992) Eosinophil degranulation in the respiratory tract during naturally acquired respiratory syncytial virus infection. J Pediatr 120:28\u201332","journal-title":"J Pediatr"},{"key":"8368_CR319","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1164\/ajrccm.159.3.9801052","volume":"159","author":"GP Rakes","year":"1999","unstructured":"Rakes GP, Arruda E, Ingram JM et al (1999) Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care. IgE and eosinophil analyses. Am J Respir Crit Care Med 159:785\u2013790","journal-title":"Am J Respir Crit Care Med"},{"key":"8368_CR320","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1399-3038.1996.tb00130.x","volume":"7","author":"K \u00d8ymar","year":"1996","unstructured":"\u00d8ymar K, Elsayed S, Bjerknes R (1996) Serum eosinophil cationic protein and interleukin-5 in children with bronchial asthma and acute bronchiolitis. Pediatr Allergy Immunol 7:180\u2013186","journal-title":"Pediatr Allergy Immunol"},{"key":"8368_CR321","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0022-3476(97)70243-9","volume":"130","author":"PM Renzi","year":"1997","unstructured":"Renzi PM, Turgeon JP, Yang JP et al (1997) Cellular immunity is activated and a TH-2 response is associated with early wheezing in infants after bronchiolitis. J Pediatr 130:584\u2013593","journal-title":"J Pediatr"},{"key":"8368_CR322","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1542\/peds.105.1.79","volume":"105","author":"DR Ehlenfield","year":"2000","unstructured":"Ehlenfield DR, Cameron K, Welliver RC (2000) Eosinophilia at the time of respiratory syncytial virus bronchiolitis predicts childhood reactive airway disease. Pediatrics 105:79\u201383","journal-title":"Pediatrics"},{"key":"8368_CR323","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3346\/jkms.2010.25.3.342","volume":"25","author":"CK Kim","year":"2010","unstructured":"Kim CK, Choi J, Callaway Z et al (2010) Clinical and epidemiological comparison of human metapneumovirus and respiratory syncytial virus in Seoul, Korea, 2003\u20132008. J Korean Med Sci 25:342\u2013347","journal-title":"J Korean Med Sci"},{"key":"8368_CR324","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.4049\/jimmunol.179.4.2634","volume":"179","author":"J Monteseirin","year":"2007","unstructured":"Monteseirin J, Vega A, Chacon P et al (2007) Neutrophils as a novel source of eosinophil cationic protein in IgE-mediated processes. J Immunol 179:2634\u20132641","journal-title":"J Immunol"},{"key":"8368_CR325","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1056\/NEJM198110083051501","volume":"305","author":"RC Welliver","year":"1981","unstructured":"Welliver RC, Wong DT, Sun M, Middleton E Jr, Vaughan RS, Ogra PL (1981) The development of respiratory syncytial virus-specific IgE and the release of histamine in nasopharyngeal secretions after infection. N Engl J Med 305:841\u2013846","journal-title":"N Engl J Med"},{"key":"8368_CR326","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1128\/jcm.31.4.819-823.1993","volume":"31","author":"JC Russi","year":"1993","unstructured":"Russi JC, Delfraro A, Borthagaray MD, Velazquez B, Garcia-Barreno B, Hortal M (1993) Evaluation of immunoglobulin E-specific antibodies and viral antigens in nasopharyngeal secretions of children with respiratory syncytial virus infections. J Clin Microbiol 31:819\u2013823","journal-title":"J Clin Microbiol"},{"key":"8368_CR327","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/infdis\/175.1.32","volume":"175","author":"S Rabatic","year":"1997","unstructured":"Rabatic S, Gagro A, Lokar-Kolbas R et al (1997) Increase in CD23+ B cells in infants with bronchiolitis is accompanied by appearance of IgE and IgG4 antibodies specific for respiratory syncytial virus. J Infect Dis 175:32\u201337","journal-title":"J Infect Dis"},{"key":"8368_CR328","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1067\/mpd.2001.111277","volume":"138","author":"A De Alarcon","year":"2001","unstructured":"De Alarcon A, Walsh EE, Carper HT et al (2001) Detection of IgA and IgG but not IgE antibody to respiratory syncytial virus in nasal washes and sera from infants with wheezing. J Pediatr 138:311\u2013317","journal-title":"J Pediatr"},{"key":"8368_CR329","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1164\/rccm.200412-1693OC","volume":"172","author":"L Tortorolo","year":"2005","unstructured":"Tortorolo L, Langer A, Polidori G et al (2005) Neurotrophin overexpression in lower airways of infants with respiratory syncytial virus infection. Am J Respir Crit Care Med 172:233\u2013237","journal-title":"Am J Respir Crit Care Med"},{"key":"8368_CR330","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1128\/jcm.30.6.1479-1484.1992","volume":"30","author":"O Meurman","year":"1992","unstructured":"Meurman O, Waris M, Hedman K (1992) Immunoglobulin G antibody avidity in patients with respiratory syncytial virus infection. J Clin Microbiol 30:1479\u20131484","journal-title":"J Clin Microbiol"},{"key":"8368_CR331","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1128\/jcm.24.5.894-898.1986","volume":"24","author":"BR Murphy","year":"1986","unstructured":"Murphy BR, Alling DW, Snyder MH et al (1986) Effect of age and preexisting antibody on serum antibody response of infants and children to the F and G glycoproteins during respiratory syncytial virus infection. J Clin Microbiol 24:894\u2013898","journal-title":"J Clin Microbiol"},{"key":"8368_CR332","first-page":"369","volume":"43","author":"J Wilczynski","year":"1994","unstructured":"Wilczynski J, Lukasik B, Torbicka E, Tranda I, Brzozowska-Binda A (1994) The immune response of small children by antibodies of different classes to respiratory syncytial virus (RSV) proteins. Acta Microbiol Pol 43:369\u2013379","journal-title":"Acta Microbiol Pol"},{"key":"8368_CR333","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/jmv.1890270307","volume":"27","author":"T Popow-Kraupp","year":"1989","unstructured":"Popow-Kraupp T, Lakits E, Kellner G, Kunz C (1989) Immunoglobulin-class-specific immune response to respiratory syncytial virus structural proteins in infants, children, and adults. J Med Virol 27:215\u2013223","journal-title":"J Med Virol"},{"key":"8368_CR334","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1128\/jcm.23.6.1009-1014.1986","volume":"23","author":"BR Murphy","year":"1986","unstructured":"Murphy BR, Graham BS, Prince GA et al (1986) Serum and nasal-wash immunoglobulin G and A antibody response of infants and children to respiratory syncytial virus F and G glycoproteins following primary infection. J Clin Microbiol 23:1009\u20131014","journal-title":"J Clin Microbiol"},{"key":"8368_CR335","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/infdis\/163.4.693","volume":"163","author":"CB Hall","year":"1991","unstructured":"Hall CB, Walsh EE, Long CE, Schnabel KC (1991) Immunity to and frequency of reinfection with respiratory syncytial virus. J Infect Dis 163:693\u2013698","journal-title":"J Infect Dis"},{"key":"8368_CR336","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1086\/421524","volume":"190","author":"EE Walsh","year":"2004","unstructured":"Walsh EE, Falsey AR (2004) Humoral and mucosal immunity in protection from natural respiratory syncytial virus infection in adults. J Infect Dis 190:373\u2013378","journal-title":"J Infect Dis"},{"key":"8368_CR337","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.molimm.2009.08.024","volume":"47","author":"JV Williams","year":"2009","unstructured":"Williams JV, Weitkamp JH, Blum DL, LaFleur BJ, Crowe JE Jr (2009) The human neonatal B cell response to respiratory syncytial virus uses a biased antibody variable gene repertoire that lacks somatic mutations. Mol Immunol 47:407\u2013414","journal-title":"Mol Immunol"},{"key":"8368_CR338","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1086\/597386","volume":"199","author":"JL Reed","year":"2009","unstructured":"Reed JL, Welliver TP, Sims GP et al (2009) Innate immune signals modulate antiviral and polyreactive antibody responses during severe respiratory syncytial virus infection. J Infect Dis 199:1128\u20131138","journal-title":"J Infect Dis"},{"key":"8368_CR339","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1128\/jcm.27.2.295-299.1989","volume":"27","author":"RC Welliver","year":"1989","unstructured":"Welliver RC, Sun M, Hildreth SW, Arumugham R, Ogra PL (1989) Respiratory syncytial virus-specific antibody responses in immunoglobulin A and E isotypes to the F and G proteins and to intact virus after natural infection. J Clin Microbiol 27:295\u2013299","journal-title":"J Clin Microbiol"},{"key":"8368_CR340","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1164\/ajrccm.160.4.9812025","volume":"160","author":"JH Aberle","year":"1999","unstructured":"Aberle JH, Aberle SW, Dworzak MN et al (1999) Reduced interferon-gamma expression in peripheral blood mononuclear cells of infants with severe respiratory syncytial virus disease. Am J Respir Crit Care Med 160:1263\u20131268","journal-title":"Am J Respir Crit Care Med"},{"key":"8368_CR341","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0022-3476(87)80295-0","volume":"110","author":"RH Bui","year":"1987","unstructured":"Bui RH, Molinaro GA, Kettering JD, Heiner DC, Imagawa DT, St Geme JW Jr (1987) Virus-specific IgE and IgG4 antibodies in serum of children infected with respiratory syncytial virus. J Pediatr 110:87\u201390","journal-title":"J Pediatr"},{"key":"8368_CR342","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1542\/peds.2007-1889","volume":"121","author":"SF Thomsen","year":"2008","unstructured":"Thomsen SF, Stensballe LG, Skytthe A, Kyvik KO, Backer V, Bisgaard H (2008) Increased concordance of severe respiratory syncytial virus infection in identical twins. Pediatrics 121:493\u2013496","journal-title":"Pediatrics"},{"key":"8368_CR343","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/jmv.10225","volume":"68","author":"M Venter","year":"2002","unstructured":"Venter M, Collinson M, Schoub BD (2002) Molecular epidemiological analysis of community circulating respiratory syncytial virus in rural South Africa: Comparison of viruses and genotypes responsible for different disease manifestations. J Med Virol 68:452\u2013461","journal-title":"J Med Virol"},{"key":"8368_CR344","doi-asserted-by":"crossref","first-page":"5384","DOI":"10.4049\/jimmunol.1001594","volume":"185","author":"JS Tregoning","year":"2010","unstructured":"Tregoning JS, Yamaguchi Y, Wang B et al (2010) Genetic susceptibility to the delayed sequelae of neonatal respiratory syncytial virus infection is MHC dependent. J Immunol 185:5384\u20135391","journal-title":"J Immunol"},{"key":"8368_CR345","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1086\/520886","volume":"196","author":"R Janssen","year":"2007","unstructured":"Janssen R, Bont L, Siezen CL et al (2007) Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. J Infect Dis 196:826\u2013834","journal-title":"J Infect Dis"},{"key":"8368_CR346","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/INF.0b013e31818e2aa9","volume":"28","author":"CL Siezen","year":"2009","unstructured":"Siezen CL, Bont L, Hodemaekers HM et al (2009) Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. Pediatr Infect Dis J 28:333\u2013335","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR347","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1002\/jmv.22179","volume":"83","author":"TL Kresfelder","year":"2011","unstructured":"Kresfelder TL, Janssen R, Bont L, Pretorius M, Venter M (2011) Confirmation of an association between single nucleotide polymorphisms in the VDR gene with respiratory syncytial virus related disease in South African children. J Med Virol 83:1834\u20131840","journal-title":"J Med Virol"},{"key":"8368_CR348","doi-asserted-by":"crossref","first-page":"11359","DOI":"10.1128\/JVI.00804-10","volume":"84","author":"D Marchant","year":"2010","unstructured":"Marchant D, Singhera GK, Utokaparch S et al (2010) Toll-like receptor 4-mediated activation of p38 mitogen-activated protein kinase is a determinant of respiratory virus entry and tropism. J Virol 84:11359\u201311373","journal-title":"J Virol"},{"key":"8368_CR349","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/80833","volume":"1","author":"EA Kurt-Jones","year":"2000","unstructured":"Kurt-Jones EA, Popova L, Kwinn L et al (2000) Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol 1:398\u2013401","journal-title":"Nat Immunol"},{"key":"8368_CR350","doi-asserted-by":"crossref","first-page":"10730","DOI":"10.1128\/JVI.75.22.10730-10737.2001","volume":"75","author":"LM Haynes","year":"2001","unstructured":"Haynes LM, Moore DD, Kurt-Jones EA, Finberg RW, Anderson LJ, Tripp RA (2001) Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus. J Virol 75:10730\u201310737","journal-title":"J Virol"},{"key":"8368_CR351","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1086\/344644","volume":"186","author":"HA Haeberle","year":"2002","unstructured":"Haeberle HA, Takizawa R, Casola A et al (2002) Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways. J Infect Dis 186:1199\u20131206","journal-title":"J Infect Dis"},{"key":"8368_CR352","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1365-2249.2004.02364.x","volume":"135","author":"A Gagro","year":"2004","unstructured":"Gagro A, Tominac M, Krsulovic-Hresic V et al (2004) Increased Toll-like receptor 4 expression in infants with respiratory syncytial virus bronchiolitis. Clin Exp Immunol 135:267\u2013272","journal-title":"Clin Exp Immunol"},{"key":"8368_CR353","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1136\/thx.2008.107821","volume":"64","author":"CP Halfhide","year":"2009","unstructured":"Halfhide CP, Brearey SP, Flanagan BF et al (2009) Neutrophil TLR4 expression is reduced in the airways of infants with severe bronchiolitis. Thorax 64:798\u2013805","journal-title":"Thorax"},{"key":"8368_CR354","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4049\/jimmunol.179.1.132","volume":"179","author":"MK Tulic","year":"2007","unstructured":"Tulic MK, Hurrelbrink RJ, Prele CM et al (2007) TLR4 polymorphisms mediate impaired responses to respiratory syncytial virus and lipopolysaccharide. J Immunol 179:132\u2013140","journal-title":"J Immunol"},{"key":"8368_CR355","doi-asserted-by":"crossref","first-page":"e12087","DOI":"10.1371\/journal.pone.0012087","volume":"5","author":"RN Douville","year":"2010","unstructured":"Douville RN, Lissitsyn Y, Hirschfeld AF et al (2010) TLR4 Asp299Gly and Thr399Ile polymorphisms: no impact on human immune responsiveness to LPS or respiratory syncytial virus. PLoS One 5:e12087","journal-title":"PLoS One"},{"key":"8368_CR356","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.4049\/jimmunol.179.5.3171","volume":"179","author":"AA Awomoyi","year":"2007","unstructured":"Awomoyi AA, Rallabhandi P, Pollin TI et al (2007) Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children. J Immunol 179:3171\u20133177","journal-title":"J Immunol"},{"key":"8368_CR357","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1086\/420830","volume":"189","author":"G Tal","year":"2004","unstructured":"Tal G, Mandelberg A, Dalal I et al (2004) Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease. J Infect Dis 189:2057\u20132063","journal-title":"J Infect Dis"},{"key":"8368_CR358","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1086\/516790","volume":"195","author":"Y Inoue","year":"2007","unstructured":"Inoue Y, Shimojo N, Suzuki Y et al (2007) CD14\u2013550 C\/T, which is related to the serum level of soluble CD14, is associated with the development of respiratory syncytial virus bronchiolitis in the Japanese population. J Infect Dis 195:1618\u20131624","journal-title":"J Infect Dis"},{"key":"8368_CR359","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1155\/2006\/865890","volume":"22","author":"B Puthothu","year":"2006","unstructured":"Puthothu B, Forster J, Heinzmann A, Krueger M (2006) TLR-4 and CD14 polymorphisms in respiratory syncytial virus associated disease. Dis Markers 22:303\u2013308","journal-title":"Dis Markers"},{"key":"8368_CR360","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/ppul.21248","volume":"45","author":"J L\u00f6fgren","year":"2010","unstructured":"L\u00f6fgren J, Marttila R, Renko M, R\u00e4met M, Hallman M (2010) Toll-like receptor 4 Asp299Gly polymorphism in respiratory syncytial virus epidemics. Pediatr Pulmonol 45:687\u2013692","journal-title":"Pediatr Pulmonol"},{"key":"8368_CR361","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/ppul.20793","volume":"43","author":"M Helminen","year":"2008","unstructured":"Helminen M, Nuolivirta K, Virta M et al (2008) IL-10 gene polymorphism at -1082 A\/G is associated with severe rhinovirus bronchiolitis in infants. Pediatr Pulmonol 43:391\u2013395","journal-title":"Pediatr Pulmonol"},{"key":"8368_CR362","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1155\/2008\/619595","volume":"25","author":"B Mailaparambil","year":"2008","unstructured":"Mailaparambil B, Krueger M, Heinze J, Forster J, Heinzmann A (2008) Polymorphisms of toll like receptors in the genetics of severe RSV associated diseases. Dis Markers 25:59\u201365","journal-title":"Dis Markers"},{"key":"8368_CR363","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/ppul.21348","volume":"46","author":"M R\u00e4met","year":"2011","unstructured":"R\u00e4met M, Korppi M, Hallman M (2011) Pattern recognition receptors and genetic risk for RSV infection: value for clinical decision-making? Pediatr Pulmonol 46:101\u2013110","journal-title":"Pediatr Pulmonol"},{"key":"8368_CR364","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/vim.2000.13.125","volume":"13","author":"TP Hickling","year":"2000","unstructured":"Hickling TP, Malhotra R, Bright H, McDowell W, Blair ED, Sim RB (2000) Lung surfactant protein A provides a route of entry for respiratory syncytial virus into host cells. Viral Immunol 13:125\u2013135","journal-title":"Viral Immunol"},{"key":"8368_CR365","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1086\/315134","volume":"180","author":"R Ghildyal","year":"1999","unstructured":"Ghildyal R, Hartley C, Varrasso A et al (1999) Surfactant protein A binds to the fusion glycoprotein of respiratory syncytial virus and neutralizes virion infectivity. J Infect Dis 180:2009\u20132013","journal-title":"J Infect Dis"},{"key":"8368_CR366","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1165\/ajrcmb.23.5.3771","volume":"23","author":"FE Barr","year":"2000","unstructured":"Barr FE, Pedigo H, Johnson TR, Shepherd VL (2000) Surfactant protein-A enhances uptake of respiratory syncytial virus by monocytes and U937 macrophages. Am J Respir Cell Mol Biol 23:586\u2013592","journal-title":"Am J Respir Cell Mol Biol"},{"key":"8368_CR367","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1164\/ajrccm.159.4.9709065","volume":"159","author":"MH Kerr","year":"1999","unstructured":"Kerr MH, Paton JY (1999) Surfactant protein levels in severe respiratory syncytial virus infection. Am J Respir Crit Care Med 159:1115\u20131118","journal-title":"Am J Respir Crit Care Med"},{"key":"8368_CR368","first-page":"CD009194","volume":"9","author":"KR Jat","year":"2012","unstructured":"Jat KR, Chawla D (2012) Surfactant therapy for bronchiolitis in critically ill infants. Cochrane Database Syst Rev 9:CD009194","journal-title":"Cochrane Database Syst Rev"},{"key":"8368_CR369","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1203\/PDR.0b013e3181a1d768","volume":"66","author":"NJ Thomas","year":"2009","unstructured":"Thomas NJ, DiAngelo S, Hess JC et al (2009) Transmission of surfactant protein variants and haplotypes in children hospitalized with respiratory syncytial virus. Pediatr Res 66:70\u201373","journal-title":"Pediatr Res"},{"key":"8368_CR370","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1086\/338473","volume":"185","author":"J L\u00f6fgren","year":"2002","unstructured":"L\u00f6fgren J, R\u00e4met M, Renko M, Marttila R, Hallman M (2002) Association between surfactant protein A gene locus and severe respiratory syncytial virus infection in infants. J Infect Dis 185:283\u2013289","journal-title":"J Infect Dis"},{"key":"8368_CR371","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.meegid.2011.04.033","volume":"11","author":"S Ampuero","year":"2011","unstructured":"Ampuero S, Luchsinger V, Tapia L, Palomino MA, Larranaga CE (2011) SP-A1, SP-A2 and SP-D gene polymorphisms in severe acute respiratory syncytial infection in Chilean infants. Infect Genet Evol 11:1368\u20131377","journal-title":"Infect Genet Evol"},{"key":"8368_CR372","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jpeds.2009.09.043","volume":"156","author":"CM El Saleeby","year":"2010","unstructured":"El Saleeby CM, Li R, Somes GW, Dahmer MK, Quasney MW, DeVincenzo JP (2010) Surfactant protein A2 polymorphisms and disease severity in a respiratory syncytial virus-infected population. J Pediatr 156:409\u2013414","journal-title":"J Pediatr"},{"key":"8368_CR373","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2466-7-6","volume":"7","author":"B Puthothu","year":"2007","unstructured":"Puthothu B, Forster J, Heinze J, Heinzmann A, Krueger M (2007) Surfactant protein B polymorphisms are associated with severe respiratory syncytial virus infection, but not with asthma. BMC Pulm Med 7:6","journal-title":"BMC Pulm Med"},{"key":"8368_CR374","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1399-3038.2006.00467.x","volume":"17","author":"B Puthothu","year":"2006","unstructured":"Puthothu B, Krueger M, Heinze J, Forster J, Heinzmann A (2006) Haplotypes of surfactant protein C are associated with common paediatric lung diseases. Pediatr Allergy Immunol 17:572\u2013577","journal-title":"Pediatr Allergy Immunol"},{"key":"8368_CR375","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1203\/00006450-200206000-00006","volume":"51","author":"M Lahti","year":"2002","unstructured":"Lahti M, Lofgren J, Marttila R et al (2002) Surfactant protein D gene polymorphism associated with severe respiratory syncytial virus infection. Pediatr Res 51:696\u2013699","journal-title":"Pediatr Res"},{"key":"8368_CR376","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s00431-008-0870-3","volume":"168","author":"M Tian","year":"2009","unstructured":"Tian M, Liu F, Wen GY, Shi SY, Chen RH, Zhao DY (2009) Effect of variation in RANTES promoter on serum RANTES levels and risk of recurrent wheezing after RSV bronchiolitis in children from Han, Southern China. Eur J Pediatr 168:963\u2013967","journal-title":"Eur J Pediatr"},{"key":"8368_CR377","doi-asserted-by":"crossref","first-page":"242","DOI":"10.7883\/yoken.64.242","volume":"64","author":"S Hattori","year":"2011","unstructured":"Hattori S, Shimojo N, Mashimo T et al (2011) Relationship between RANTES polymorphisms and respiratory syncytial virus bronchiolitis in a Japanese infant population. Jpn J Infect Dis 64:242\u2013245","journal-title":"Jpn J Infect Dis"},{"key":"8368_CR378","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/INF.0b013e31814d4e42","volume":"27","author":"V Amanatidou","year":"2008","unstructured":"Amanatidou V, Sourvinos G, Apostolakis S et al (2008) RANTES promoter gene polymorphisms and susceptibility to severe respiratory syncytial virus-induced bronchiolitis. Pediatr Infect Dis J 27:38\u201342","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR379","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1086\/377587","volume":"188","author":"J Hull","year":"2003","unstructured":"Hull J, Rowlands K, Lockhart E, Moore C, Sharland M, Kwiatkowski D (2003) Variants of the chemokine receptor CCR5 are associated with severe bronchiolitis caused by respiratory syncytial virus. J Infect Dis 188:904\u2013907","journal-title":"J Infect Dis"},{"key":"8368_CR380","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1136\/thorax.55.12.1023","volume":"55","author":"J Hull","year":"2000","unstructured":"Hull J, Thomson A, Kwiatkowski D (2000) Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families. Thorax 55:1023\u20131027","journal-title":"Thorax"},{"key":"8368_CR381","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1086\/321291","volume":"69","author":"J Hull","year":"2001","unstructured":"Hull J, Ackerman H, Isles K et al (2001) Unusual haplotypic structure of IL8, a susceptibility locus for a common respiratory virus. Am J Hum Genet 69:413\u2013419","journal-title":"Am J Hum Genet"},{"key":"8368_CR382","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/sj.gene.6364067","volume":"5","author":"D Hacking","year":"2004","unstructured":"Hacking D, Knight JC, Rockett K et al (2004) Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibility. Genes Immun 5:274\u2013282","journal-title":"Genes Immun"},{"key":"8368_CR383","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/tropej\/fmp101","volume":"56","author":"A Lu","year":"2010","unstructured":"Lu A, Wang L, Zhang X (2010) Haplotype of IL-8\u2013251T and 781C is associated with the susceptibility to respiratory syncytial virus. J Trop Pediatr 56:242\u2013246","journal-title":"J Trop Pediatr"},{"key":"8368_CR384","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1476-7961-4-2","volume":"4","author":"B Puthothu","year":"2006","unstructured":"Puthothu B, Krueger M, Heinze J, Forster J, Heinzmann A (2006) Impact of IL8 and IL8-receptor alpha polymorphisms on the genetics of bronchial asthma and severe RSV infections. Clin Mol Allergy 4:2","journal-title":"Clin Mol Allergy"},{"issue":"Suppl 2","key":"8368_CR385","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1365-2222.1995.tb00428.x","volume":"25","author":"LJ Rosenwasser","year":"1995","unstructured":"Rosenwasser LJ, Klemm DJ, Dresback JK et al (1995) Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy. Clin Exp Allergy 25(Suppl 2):74\u201378, discussion 95\u201376","journal-title":"Clin Exp Allergy"},{"key":"8368_CR386","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/sj.gene.6363630","volume":"1","author":"TC van der Pouw Kraan","year":"1999","unstructured":"van der Pouw Kraan TC, van Veen A, Boeije LC et al (1999) An IL-13 promoter polymorphism associated with increased risk of allergic asthma. Genes Immun 1:61\u201365","journal-title":"Genes Immun"},{"key":"8368_CR387","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1136\/thx.2008.102111","volume":"64","author":"JT Forton","year":"2009","unstructured":"Forton JT, Rowlands K, Rockett K et al (2009) Genetic association study for RSV bronchiolitis in infancy at the 5q31 cytokine cluster. Thorax 64:345\u2013352","journal-title":"Thorax"},{"key":"8368_CR388","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1086\/499316","volume":"193","author":"B Puthothu","year":"2006","unstructured":"Puthothu B, Krueger M, Forster J, Heinzmann A (2006) Association between severe respiratory syncytial virus infection and IL13\/IL4 haplotypes. J Infect Dis 193:438\u2013441","journal-title":"J Infect Dis"},{"key":"8368_CR389","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1086\/344310","volume":"186","author":"EH Choi","year":"2002","unstructured":"Choi EH, Lee HJ, Yoo T, Chanock SJ (2002) A common haplotype of interleukin-4 gene IL4 is associated with severe respiratory syncytial virus disease in Korean children. J Infect Dis 186:1207\u20131211","journal-title":"J Infect Dis"},{"key":"8368_CR390","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1086\/345859","volume":"187","author":"B Hoebee","year":"2003","unstructured":"Hoebee B, Rietveld E, Bont L et al (2003) Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms. J Infect Dis 187:2\u201311","journal-title":"J Infect Dis"},{"key":"8368_CR391","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1086\/380908","volume":"189","author":"B Hoebee","year":"2004","unstructured":"Hoebee B, Bont L, Rietveld E et al (2004) Influence of promoter variants of interleukin-10, interleukin-9, and tumor necrosis factor-alpha genes on respiratory syncytial virus bronchiolitis. J Infect Dis 189:239\u2013247","journal-title":"J Infect Dis"},{"key":"8368_CR392","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1465-9921-12-121","volume":"12","author":"A Schuurhof","year":"2011","unstructured":"Schuurhof A, Janssen R, de Groot H et al (2011) Local interleukin-10 production during respiratory syncytial virus bronchiolitis is associated with post-bronchiolitis wheeze. Respir Res 12:121","journal-title":"Respir Res"},{"key":"8368_CR393","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1086\/429636","volume":"191","author":"J Wilson","year":"2005","unstructured":"Wilson J, Rowlands K, Rockett K et al (2005) Genetic variation at the IL10 gene locus is associated with severity of respiratory syncytial virus bronchiolitis. J Infect Dis 191:1705\u20131709","journal-title":"J Infect Dis"},{"key":"8368_CR394","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1007\/s00705-008-0232-5","volume":"153","author":"B Mailaparambil","year":"2008","unstructured":"Mailaparambil B, Jochum J, Forster J, Heinze J, Krueger M, Heinzmann A (2008) Polymorphisms of interferons and their receptors in the genetics of severe RSV-associated diseases. Arch Virol 153:2133\u20132137","journal-title":"Arch Virol"},{"key":"8368_CR395","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0198-8859(02)00827-3","volume":"64","author":"DA Gentile","year":"2003","unstructured":"Gentile DA, Doyle WJ, Zeevi A et al (2003) Cytokine gene polymorphisms moderate illness severity in infants with respiratory syncytial virus infection. Hum Immunol 64:338\u2013344","journal-title":"Hum Immunol"},{"key":"8368_CR396","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1097\/INF.0b013e3181453579","volume":"26","author":"B Puthothu","year":"2007","unstructured":"Puthothu B, Krueger M, Forster J, Heinze J, Weckmann M, Heinzmann A (2007) Interleukin (IL)-18 polymorphism 133C\/G is associated with severe respiratory syncytial virus infection. Pediatr Infect Dis J 26:1094\u20131098","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR397","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1399-3038.2008.00751.x","volume":"20","author":"B Puthothu","year":"2009","unstructured":"Puthothu B, Bierbaum S, Kopp MV et al (2009) Association of TNF-alpha with severe respiratory syncytial virus infection and bronchial asthma. Pediatr Allergy Immunol 20:157\u2013163","journal-title":"Pediatr Allergy Immunol"},{"key":"8368_CR398","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/jmv.22073","volume":"83","author":"K Hashimoto","year":"2011","unstructured":"Hashimoto K, Katayose M, Sakuma H et al (2011) Uteroglobulin-related protein 1 and severity of respiratory syncytial virus infection in children admitted to hospital. J Med Virol 83:1086\u20131092","journal-title":"J Med Virol"},{"key":"8368_CR399","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1651-2227.2005.tb01910.x","volume":"94","author":"M Aurivillius","year":"2005","unstructured":"Aurivillius M, Oymar K, Oxelius VA (2005) Immunoglobulin heavy G2 chain (IGHG2) gene restriction in the development of severe respiratory syncytial virus infection. Acta Paediatr 94:414\u2013418","journal-title":"Acta Paediatr"},{"key":"8368_CR400","doi-asserted-by":"crossref","first-page":"6215","DOI":"10.4049\/jimmunol.161.11.6215","volume":"161","author":"T Hussell","year":"1998","unstructured":"Hussell T, Georgiou A, Sparer TE, Matthews S, Pala P, Openshaw PJ (1998) Host genetic determinants of vaccine-induced eosinophilia during respiratory syncytial virus infection. J Immunol 161:6215\u20136222","journal-title":"J Immunol"},{"key":"8368_CR401","doi-asserted-by":"crossref","first-page":"10135","DOI":"10.1128\/JVI.00816-11","volume":"85","author":"B Jessen","year":"2011","unstructured":"Jessen B, Faller S, Krempl CD, Ehl S (2011) Major histocompatibility complex-dependent cytotoxic T lymphocyte repertoire and functional avidity contribute to strain-specific disease susceptibility after murine respiratory syncytial virus infection. J Virol 85:10135\u201310143","journal-title":"J Virol"},{"key":"8368_CR402","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1128\/JVI.00584-09","volume":"84","author":"JM Stark","year":"2010","unstructured":"Stark JM, Barmada MM, Winterberg AV et al (2010) Genomewide association analysis of respiratory syncytial virus infection in mice. J Virol 84:2257\u20132269","journal-title":"J Virol"},{"key":"8368_CR403","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1651-2227.2011.02408.x","volume":"101","author":"H Over\u00f6dder","year":"2012","unstructured":"Over\u00f6dder H, Nav\u00e9r L (2012) Clara cell protein 10 polymorphism is not associated with severe respiratory syncytial virus infection. Acta Paediatr 101:34\u201337","journal-title":"Acta Paediatr"},{"key":"8368_CR404","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1399-3038.2005.00298.x","volume":"16","author":"J Henderson","year":"2005","unstructured":"Henderson J, Hilliard TN, Sherriff A, Stalker D, Al Shammari N, Thomas HM (2005) Hospitalization for RSV bronchiolitis before 12 months of age and subsequent asthma, atopy and wheeze: a longitudinal birth cohort study. Pediatr Allergy Immunol 16:386\u2013392","journal-title":"Pediatr Allergy Immunol"},{"key":"8368_CR405","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2431-5-31","volume":"5","author":"HO Fj\u00e6rli","year":"2005","unstructured":"Fj\u00e6rli HO, Farstad T, R\u00f8d G, Ufert GK, Gulbrandsen P, Nakstad B (2005) Acute bronchiolitis in infancy as risk factor for wheezing and reduced pulmonary function by seven years in Akershus County, Norway. BMC Pediatr 5:31","journal-title":"BMC Pediatr"},{"key":"8368_CR406","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1542\/peds.112.2.285","volume":"112","author":"RJ Singleton","year":"2003","unstructured":"Singleton RJ, Redding GJ, Lewis TC et al (2003) Sequelae of severe respiratory syncytial virus infection in infancy and early childhood among Alaska Native children. Pediatrics 112:285\u2013290","journal-title":"Pediatrics"},{"key":"8368_CR407","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1183\/09031936.02.00019902","volume":"20","author":"U Schauer","year":"2002","unstructured":"Schauer U, Hoffjan S, Bittscheidt J et al (2002) RSV bronchiolitis and risk of wheeze and allergic sensitisation in the first year of life. Eur Respir J 20:1277\u20131283","journal-title":"Eur Respir J"},{"key":"8368_CR408","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/BF01957225","volume":"152","author":"VM Osundwa","year":"1993","unstructured":"Osundwa VM, Dawod ST, Ehlayel M (1993) Recurrent wheezing in children with respiratory syncytial virus (RSV) bronchiolitis in Qatar. Eur J Pediatr 152:1001\u20131003","journal-title":"Eur J Pediatr"},{"key":"8368_CR409","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1136\/adc.67.4.482","volume":"67","author":"M Murray","year":"1992","unstructured":"Murray M, Webb MS, O\u2019Callaghan C, Swarbrick AS, Milner AD (1992) Respiratory status and allergy after bronchiolitis. Arch Dis Child 67:482\u2013487","journal-title":"Arch Dis Child"},{"key":"8368_CR410","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/bmj.1.6104.11","volume":"1","author":"DG Sims","year":"1978","unstructured":"Sims DG, Downham MA, Gardner PS, Webb JK, Weightman D (1978) Study of 8-year-old children with a history of respiratory syncytial virus bronchiolitis in infancy. Br Med J 1:11\u201314","journal-title":"Br Med J"},{"key":"8368_CR411","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1034\/j.1399-3038.2000.00076.x","volume":"11","author":"M Eriksson","year":"2000","unstructured":"Eriksson M, Bennet R, Nilsson A (2000) Wheezing following lower respiratory tract infections with respiratory syncytial virus and influenza A in infancy. Pediatr Allergy Immunol 11:193\u2013197","journal-title":"Pediatr Allergy Immunol"},{"key":"8368_CR412","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1067\/mai.2003.33","volume":"111","author":"A Kotaniemi-Syrj\u00e4nen","year":"2003","unstructured":"Kotaniemi-Syrj\u00e4nen A, Vainionp\u00e4\u00e4 R, Reijonen TM, Waris M, Korhonen K, Korppi M (2003) Rhinovirus-induced wheezing in infancy\u2014the first sign of childhood asthma? J Allergy Clin Immunol 111:66\u201371","journal-title":"J Allergy Clin Immunol"},{"key":"8368_CR413","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1542\/peds.95.4.500","volume":"95","author":"N Sigurs","year":"1995","unstructured":"Sigurs N, Bjarnason R, Sigurbergsson F, Kjellman B, Bjorksten B (1995) Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: a prospective cohort study with matched controls. Pediatrics 95:500\u2013505","journal-title":"Pediatrics"},{"key":"8368_CR414","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1164\/ajrccm.161.5.9906076","volume":"161","author":"N Sigurs","year":"2000","unstructured":"Sigurs N, Bjarnason R, Sigurbergsson F, Kjellman B (2000) Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am J Respir Crit Care Med 161:1501\u20131507","journal-title":"Am J Respir Crit Care Med"},{"key":"8368_CR415","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1164\/rccm.200406-730OC","volume":"171","author":"N Sigurs","year":"2005","unstructured":"Sigurs N, Gustafsson PM, Bjarnason R et al (2005) Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13. Am J Respir Crit Care Med 171:137\u2013141","journal-title":"Am J Respir Crit Care Med"},{"key":"8368_CR416","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1136\/thx.2009.121582","volume":"65","author":"N Sigurs","year":"2010","unstructured":"Sigurs N, Aljassim F, Kjellman B et al (2010) Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life. Thorax 65:1045\u20131052","journal-title":"Thorax"},{"key":"8368_CR417","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1136\/adc.76.4.315","volume":"76","author":"V Noble","year":"1997","unstructured":"Noble V, Murray M, Webb MS, Alexander J, Swarbrick AS, Milner AD (1997) Respiratory status and allergy nine to 10 years after acute bronchiolitis. Arch Dis Child 76:315\u2013319","journal-title":"Arch Dis Child"},{"key":"8368_CR418","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1136\/bmj.285.6338.333","volume":"285","author":"JY Mok","year":"1982","unstructured":"Mok JY, Simpson H (1982) Outcome of acute lower respiratory tract infection in infants: preliminary report of seven-year follow-up study. Br Med J (Clin Res Ed) 285:333\u2013337","journal-title":"Br Med J (Clin Res Ed)"},{"key":"8368_CR419","doi-asserted-by":"crossref","first-page":"433","DOI":"10.7883\/yoken.64.433","volume":"64","author":"A Narita","year":"2011","unstructured":"Narita A, Nishimura N, Arakawa Y et al (2011) Relationship between lower respiratory tract infections caused by respiratory syncytial virus and subsequent development of asthma in Japanese children. Jpn J Infect Dis 64:433\u2013435","journal-title":"Jpn J Infect Dis"},{"key":"8368_CR420","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1136\/bmj.284.6330.1665","volume":"284","author":"CR Pullan","year":"1982","unstructured":"Pullan CR, Hey EN (1982) Wheezing, asthma, and pulmonary dysfunction 10 years after infection with respiratory syncytial virus in infancy. Br Med J (Clin Res Ed) 284:1665\u20131669","journal-title":"Br Med J (Clin Res Ed)"},{"key":"8368_CR421","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1136\/adc.59.4.299","volume":"59","author":"JY Mok","year":"1984","unstructured":"Mok JY, Simpson H (1984) Symptoms, atopy, and bronchial reactivity after lower respiratory infection in infancy. Arch Dis Child 59:299\u2013305","journal-title":"Arch Dis Child"},{"key":"8368_CR422","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1399-3038.2012.01283.x","volume":"23","author":"IB Mikalsen","year":"2012","unstructured":"Mikalsen IB, Halvorsen T, Oymar K (2012) The outcome after severe bronchiolitis is related to gender and virus. Pediatr Allergy Immunol 23:391\u2013398","journal-title":"Pediatr Allergy Immunol"},{"key":"8368_CR423","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.74.1.1","volume":"74","author":"KM McConnochie","year":"1984","unstructured":"McConnochie KM, Roghmann KJ (1984) Bronchiolitis as a possible cause of wheezing in childhood: new evidence. Pediatrics 74:1\u201310","journal-title":"Pediatrics"},{"key":"8368_CR424","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/ppul.1950060303","volume":"6","author":"KM McConnochie","year":"1989","unstructured":"McConnochie KM, Roghmann KJ (1989) Wheezing at 8 and 13 years: changing importance of bronchiolitis and passive smoking. Pediatr Pulmonol 6:138\u2013146","journal-title":"Pediatr Pulmonol"},{"key":"8368_CR425","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0140-6736(98)10321-5","volume":"354","author":"RT Stein","year":"1999","unstructured":"Stein RT, Sherrill D, Morgan WJ et al (1999) Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13\u00a0years. Lancet 354:541\u2013545","journal-title":"Lancet"},{"key":"8368_CR426","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1164\/rccm.200802-309OC","volume":"178","author":"DJ Jackson","year":"2008","unstructured":"Jackson DJ, Gangnon RE, Evans MD et al (2008) Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med 178:667\u2013672","journal-title":"Am J Respir Crit Care Med"},{"key":"8368_CR427","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1164\/rccm.201104-0660OC","volume":"185","author":"DJ Jackson","year":"2012","unstructured":"Jackson DJ, Evans MD, Gangnon RE et al (2012) Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life. Am J Respir Crit Care Med 185:281\u2013285","journal-title":"Am J Respir Crit Care Med"},{"key":"8368_CR428","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.jaci.2006.12.669","volume":"119","author":"MM Kusel","year":"2007","unstructured":"Kusel MM, de Klerk NH, Kebadze T et al (2007) Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol 119:1105\u20131110","journal-title":"J Allergy Clin Immunol"},{"key":"8368_CR429","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/S0022-3476(86)80692-8","volume":"109","author":"RC Welliver","year":"1986","unstructured":"Welliver RC, Sun M, Rinaldo D, Ogra PL (1986) Predictive value of respiratory syncytial virus-specific IgE responses for recurrent wheezing following bronchiolitis. J Pediatr 109:776\u2013780","journal-title":"J Pediatr"},{"key":"8368_CR430","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1136\/adc.76.3.210","volume":"76","author":"RL Smyth","year":"1997","unstructured":"Smyth RL, Fletcher JN, Thomas HM, Hart CA (1997) Immunological responses to respiratory syncytial virus infection in infancy. Arch Dis Child 76:210\u2013214","journal-title":"Arch Dis Child"},{"key":"8368_CR431","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.jaci.2012.02.028","volume":"129","author":"MA Gill","year":"2012","unstructured":"Gill MA (2012) The role of dendritic cells in asthma. J Allergy Clin Immunol 129:889\u2013901","journal-title":"J Allergy Clin Immunol"},{"key":"8368_CR432","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/eji.200425439","volume":"35","author":"AE John","year":"2005","unstructured":"John AE, Gerard CJ, Schaller M et al (2005) Respiratory syncytial virus-induced exaggeration of allergic airway disease is dependent upon CCR1-associated immune responses. Eur J Immunol 35:108\u2013116","journal-title":"Eur J Immunol"},{"key":"8368_CR433","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.4049\/jimmunol.167.2.1060","volume":"167","author":"NW Lukacs","year":"2001","unstructured":"Lukacs NW, Tekkanat KK, Berlin A et al (2001) Respiratory syncytial virus predisposes mice to augmented allergic airway responses via IL-13-mediated mechanisms. J Immunol 167:1060\u20131065","journal-title":"J Immunol"},{"key":"8368_CR434","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1002\/jmv.20944","volume":"79","author":"B Liu","year":"2007","unstructured":"Liu B, Kimura Y (2007) Respiratory syncytial virus protects against the subsequent development of Japanese cedar pollen-induced allergic responses. J Med Virol 79:1600\u20131605","journal-title":"J Med Virol"},{"key":"8368_CR435","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/jmv.10252","volume":"69","author":"M Barends","year":"2003","unstructured":"Barends M, Boelen A, de Rond L et al (2003) Respiratory syncytial virus enhances respiratory allergy in mice despite the inhibitory effect of virus-induced interferon-gamma. J Med Virol 69:156\u2013162","journal-title":"J Med Virol"},{"key":"8368_CR436","doi-asserted-by":"crossref","first-page":"134","DOI":"10.2460\/ajvr.72.1.134","volume":"72","author":"LJ Gershwin","year":"2011","unstructured":"Gershwin LJ, Anderson ML, Wang C, Berghaus LJ, Kenny TP, Gunther RA (2011) Assessment of IgE response and cytokine gene expression in pulmonary efferent lymph collected after ovalbumin inhalation during experimental infection of calves with bovine respiratory syncytial virus. Am J Vet Res 72:134\u2013145","journal-title":"Am J Vet Res"},{"key":"8368_CR437","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.cimid.2006.03.002","volume":"29","author":"WV Kalina","year":"2006","unstructured":"Kalina WV, Anderson ML, Gershwin LJ (2006) Alternaria aerosol during a bovine respiratory syncytial virus infection alters the severity of subsequent re-infection and enhances IgE production. Comp Immunol Microbiol Infect Dis 29:138\u2013156","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"8368_CR438","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1164\/ajrccm.162.2.9903057","volume":"162","author":"J Schwarze","year":"2000","unstructured":"Schwarze J, Cieslewicz G, Joetham A et al (2000) Critical roles for interleukin-4 and interleukin-5 during respiratory syncytial virus infection in the development of airway hyperresponsiveness after airway sensitization. Am J Respir Crit Care Med 162:380\u2013386","journal-title":"Am J Respir Crit Care Med"},{"key":"8368_CR439","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1136\/bmj.282.6282.2086","volume":"282","author":"DG Sims","year":"1981","unstructured":"Sims DG, Gardner PS, Weightman D, Turner MW, Soothill JF (1981) Atopy does not predispose to RSV bronchiolitis or postbronchiolitic wheezing. Br Med J (Clin Res Ed) 282:2086\u20132088","journal-title":"Br Med J (Clin Res Ed)"},{"key":"8368_CR440","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/ppul.20058","volume":"38","author":"M Korppi","year":"2004","unstructured":"Korppi M, Piippo-Savolainen E, Korhonen K, Remes S (2004) Respiratory morbidity 20 years after RSV infection in infancy. Pediatr Pulmonol 38:155\u2013160","journal-title":"Pediatr Pulmonol"},{"key":"8368_CR441","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1034\/j.1398-9995.2003.00233.x","volume":"58","author":"H Juntti","year":"2003","unstructured":"Juntti H, Kokkonen J, Dunder T, Renko M, Niinimaki A, Uhari M (2003) Association of an early respiratory syncytial virus infection and atopic allergy. Allergy 58:878\u2013884","journal-title":"Allergy"},{"key":"8368_CR442","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/ppul.1950150104","volume":"15","author":"RC Welliver","year":"1993","unstructured":"Welliver RC, Duffy L (1993) The relationship of RSV-specific immunoglobulin E antibody responses in infancy, recurrent wheezing, and pulmonary function at age 7\u20138 years. Pediatr Pulmonol 15:19\u201327","journal-title":"Pediatr Pulmonol"},{"key":"8368_CR443","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jpeds.2007.02.032","volume":"151","author":"EA Simoes","year":"2007","unstructured":"Simoes EA, Groothuis JR, Carbonell-Estrany X et al (2007) Palivizumab prophylaxis, respiratory syncytial virus, and subsequent recurrent wheezing. J Pediatr 151:34\u201342, 42 e31","journal-title":"J Pediatr"},{"key":"8368_CR444","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jaci.2010.05.026","volume":"126","author":"EA Simoes","year":"2010","unstructured":"Simoes EA, Carbonell-Estrany X, Rieger CH, Mitchell I, Fredrick L, Groothuis JR (2010) The effect of respiratory syncytial virus on subsequent recurrent wheezing in atopic and nonatopic children. J Allergy Clin Immunol 126:256\u2013262","journal-title":"J Allergy Clin Immunol"},{"key":"8368_CR445","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM199501193320301","volume":"332","author":"FD Martinez","year":"1995","unstructured":"Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ (1995) Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 332:133\u2013138","journal-title":"N Engl J Med"},{"key":"8368_CR446","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1136\/bmj.284.6322.1070","volume":"284","author":"I Laing","year":"1982","unstructured":"Laing I, Reidel F, Yap PL, Simpson H (1982) Atopy predisposing to acute bronchiolitis during an epidemic of respiratory syncytial virus. Br Med J (Clin Res Ed) 284:1070\u20131072","journal-title":"Br Med J (Clin Res Ed)"},{"key":"8368_CR447","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/1099-0496(200010)30:4<302::AID-PPUL5>3.0.CO;2-R","volume":"30","author":"P Trefny","year":"2000","unstructured":"Trefny P, Stricker T, Baerlocher C, Sennhauser FH (2000) Family history of atopy and clinical course of RSV infection in ambulatory and hospitalized infants. Pediatr Pulmonol 30:302\u2013306","journal-title":"Pediatr Pulmonol"},{"key":"8368_CR448","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.jaci.2012.01.045","volume":"129","author":"KN Carroll","year":"2012","unstructured":"Carroll KN, Gebretsadik T, Minton P et al (2012) Influence of maternal asthma on the cause and severity of infant acute respiratory tract infections. J Allergy Clin Immunol 129:1236\u20131242","journal-title":"J Allergy Clin Immunol"},{"key":"8368_CR449","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3109\/14767058.2010.482610","volume":"24","author":"EA Simoes","year":"2011","unstructured":"Simoes EA, Carbonell-Estrany X, Fullarton JR, Rossi GA, Barberi I, Lanari M (2011) European risk factors\u2019 model to predict hospitalization of premature infants born 33\u201335 weeks\u2019 gestational age with respiratory syncytial virus: validation with Italian data. J Matern Fetal Neonatal Med 24:152\u2013157","journal-title":"J Matern Fetal Neonatal Med"},{"key":"8368_CR450","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1164\/rccm.200308-1203OC","volume":"169","author":"J Schwarze","year":"2004","unstructured":"Schwarze J, O\u2019Donnell DR, Rohwedder A, Openshaw PJ (2004) Latency and persistence of respiratory syncytial virus despite T cell immunity. Am J Respir Crit Care Med 169:801\u2013805","journal-title":"Am J Respir Crit Care Med"},{"key":"8368_CR451","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1097\/INF.0b013e3181684d67","volume":"27","author":"MB Sikkel","year":"2008","unstructured":"Sikkel MB, Quint JK, Mallia P, Wedzicha JA, Johnston SL (2008) Respiratory syncytial virus persistence in chronic obstructive pulmonary disease. Pediatr Infect Dis J 27:S63\u2013S70","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR452","doi-asserted-by":"crossref","first-page":"L494","DOI":"10.1152\/ajplung.00414.2001","volume":"283","author":"C Hu","year":"2002","unstructured":"Hu C, Wedde-Beer K, Auais A, Rodriguez MM, Piedimonte G (2002) Nerve growth factor and nerve growth factor receptors in respiratory syncytial virus-infected lungs. Am J Physiol Lung Cell Mol Physiol 283:L494\u2013L502","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"8368_CR453","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jaci.2011.06.037","volume":"128","author":"TW Guilbert","year":"2011","unstructured":"Guilbert TW, Singh AM, Danov Z et al (2011) Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma. J Allergy Clin Immunol 128:532\u2013538, e531 510","journal-title":"J Allergy Clin Immunol"},{"key":"8368_CR454","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1111\/j.1651-2227.2007.00458.x","volume":"96","author":"MK Hyv\u00e4rinen","year":"2007","unstructured":"Hyv\u00e4rinen MK, Kotaniemi-Syrj\u00e4nen A, Reijonen TM, Korhonen K, Korppi MO (2007) Lung function and bronchial hyper-responsiveness 11 years after hospitalization for bronchiolitis. Acta Paediatr 96:1464\u20131469","journal-title":"Acta Paediatr"},{"key":"8368_CR455","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/adc.72.1.16","volume":"72","author":"S Young","year":"1995","unstructured":"Young S, O\u2019Keeffe PT, Arnott J, Landau LI (1995) Lung function, airway responsiveness, and respiratory symptoms before and after bronchiolitis. Arch Dis Child 72:16\u201324","journal-title":"Arch Dis Child"},{"key":"8368_CR456","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1136\/adc.87.5.417","volume":"87","author":"SW Turner","year":"2002","unstructured":"Turner SW, Young S, Landau LI, Le Souef PN (2002) Reduced lung function both before bronchiolitis and at 11 years. Arch Dis Child 87:417\u2013420","journal-title":"Arch Dis Child"},{"key":"8368_CR457","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1399-3038.2008.00781.x","volume":"20","author":"G Haland","year":"2009","unstructured":"Haland G, Lodrup Carlsen KC, Mowinckel P et al (2009) Lung function at 10 yr is not impaired by early childhood lower respiratory tract infections. Pediatr Allergy Immunol 20:254\u2013260","journal-title":"Pediatr Allergy Immunol"},{"key":"8368_CR458","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1056\/NEJM198810273191702","volume":"319","author":"FD Martinez","year":"1988","unstructured":"Martinez FD, Morgan WJ, Wright AL, Holberg CJ, Taussig LM (1988) Diminished lung function as a predisposing factor for wheezing respiratory illness in infants. N Engl J Med 319:1112\u20131117","journal-title":"N Engl J Med"},{"key":"8368_CR459","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1136\/thx.2010.148023","volume":"66","author":"SB Drysdale","year":"2011","unstructured":"Drysdale SB, Wilson T, Alcazar M et al (2011) Lung function prior to viral lower respiratory tract infections in prematurely born infants. Thorax 66:468\u2013473","journal-title":"Thorax"},{"key":"8368_CR460","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1164\/ajrccm\/143.2.312","volume":"143","author":"FD Martinez","year":"1991","unstructured":"Martinez FD, Morgan WJ, Wright AL, Holberg C, Taussig LM (1991) Initial airway function is a risk factor for recurrent wheezing respiratory illnesses during the first three years of life. Group Health Medical Associates. Am Rev Respir Dis 143:312\u2013316","journal-title":"Am Rev Respir Dis"},{"key":"8368_CR461","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1399-3038.2007.00555.x","volume":"18","author":"G Haland","year":"2007","unstructured":"Haland G, Carlsen KH, Devulapalli CS, Pettersen M, Mowinckel P, Lodrup Carlsen KC (2007) Lung function development in the first 2 yr of life is independent of allergic diseases by 2 yr. Pediatr Allergy Immunol 18:528\u2013534","journal-title":"Pediatr Allergy Immunol"},{"key":"8368_CR462","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0140-6736(07)61379-8","volume":"370","author":"DA Stern","year":"2007","unstructured":"Stern DA, Morgan WJ, Wright AL, Guerra S, Martinez FD (2007) Poor airway function in early infancy and lung function by age 22 years: a non-selective longitudinal cohort study. Lancet 370:758\u2013764","journal-title":"Lancet"},{"key":"8368_CR463","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1056\/NEJMoa022363","volume":"349","author":"MR Sears","year":"2003","unstructured":"Sears MR, Greene JM, Willan AR et al (2003) A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med 349:1414\u20131422","journal-title":"N Engl J Med"},{"key":"8368_CR464","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1164\/rccm.201110-1922OC","volume":"185","author":"H Bisgaard","year":"2012","unstructured":"Bisgaard H, Jensen SM, Bonnelykke K (2012) Interaction between asthma and lung function growth in early life. Am J Respir Crit Care Med 185:1183\u20131189","journal-title":"Am J Respir Crit Care Med"},{"key":"8368_CR465","doi-asserted-by":"crossref","unstructured":"van der Gugten AC, Uiterwaal CS, van Putte-Katier N, Koopman M, Verheij TJ, van der Ent CK (2012) Reduced neonatal lung function and wheezing illnesses during the first five years of life. Eur Respir J","DOI":"10.1183\/09031936.00214711"},{"key":"8368_CR466","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jaci.2012.04.045","volume":"130","author":"BL Chawes","year":"2012","unstructured":"Chawes BL, Poorisrisak P, Johnston SL, Bisgaard H (2012) Neonatal bronchial hyperresponsiveness precedes acute severe viral bronchiolitis in infants. J Allergy Clin Immunol 130:354\u2013361, e353","journal-title":"J Allergy Clin Immunol"},{"key":"8368_CR467","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0002-9343(02)01095-1","volume":"112","author":"SE Wenzel","year":"2002","unstructured":"Wenzel SE, Gibbs RL, Lehr MV, Simoes EA (2002) Respiratory outcomes in high-risk children 7 to 10 years after prophylaxis with respiratory syncytial virus immune globulin. Am J Med 112:627\u2013633","journal-title":"Am J Med"},{"key":"8368_CR468","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.jaci.2009.02.021","volume":"123","author":"KN Carroll","year":"2009","unstructured":"Carroll KN, Wu P, Gebretsadik T et al (2009) The severity-dependent relationship of infant bronchiolitis on the risk and morbidity of early childhood asthma. J Allergy Clin Immunol 123:1055\u20131061, 1061 e1051","journal-title":"J Allergy Clin Immunol"},{"key":"8368_CR469","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1164\/rccm.200804-579OC","volume":"178","author":"P Wu","year":"2008","unstructured":"Wu P, Dupont WD, Griffin MR et al (2008) Evidence of a causal role of winter virus infection during infancy in early childhood asthma. Am J Respir Crit Care Med 178:1123\u20131129","journal-title":"Am J Respir Crit Care Med"},{"key":"8368_CR470","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1164\/rccm.200904-0567ED","volume":"179","author":"CE Kuehni","year":"2009","unstructured":"Kuehni CE, Spycher BD, Silverman M (2009) Causal links between RSV infection and asthma: no clear answers to an old question. Am J Respir Crit Care Med 179:1079\u20131080","journal-title":"Am J Respir Crit Care Med"},{"issue":"91\u2013100","key":"8368_CR471","first-page":"e103","volume":"130","author":"LB Bacharier","year":"2012","unstructured":"Bacharier LB, Cohen R, Schweiger T et al (2012) Determinants of asthma after severe respiratory syncytial virus bronchiolitis. J Allergy Clin Immunol 130(91\u2013100):e103","journal-title":"J Allergy Clin Immunol"},{"key":"8368_CR472","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1378\/chest.10-0365","volume":"138","author":"P Poorisrisak","year":"2010","unstructured":"Poorisrisak P, Halkjaer LB, Thomsen SF et al (2010) Causal direction between respiratory syncytial virus bronchiolitis and asthma studied in monozygotic twins. Chest 138:338\u2013344","journal-title":"Chest"},{"key":"8368_CR473","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1164\/rccm.200809-1471OC","volume":"179","author":"SF Thomsen","year":"2009","unstructured":"Thomsen SF, van der Sluis S, Stensballe LG et al (2009) Exploring the association between severe respiratory syncytial virus infection and asthma: a registry-based twin study. Am J Respir Crit Care Med 179:1091\u20131097","journal-title":"Am J Respir Crit Care Med"},{"key":"8368_CR474","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1600-065X.2011.01029.x","volume":"242","author":"C Ober","year":"2011","unstructured":"Ober C, Yao TC (2011) The genetics of asthma and allergic disease: a 21st century perspective. Immunol Rev 242:10\u201330","journal-title":"Immunol Rev"},{"key":"8368_CR475","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.1365-2222.2004.1947.x","volume":"34","author":"T Goetghebuer","year":"2004","unstructured":"Goetghebuer T, Isles K, Moore C, Thomson A, Kwiatkowski D, Hull J (2004) Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis. Clin Exp Allergy 34:801\u2013803","journal-title":"Clin Exp Allergy"},{"key":"8368_CR476","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jaci.2004.06.038","volume":"114","author":"A Heinzmann","year":"2004","unstructured":"Heinzmann A, Ahlert I, Kurz T, Berner R, Deichmann KA (2004) Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis. J Allergy Clin Immunol 114:671\u2013676","journal-title":"J Allergy Clin Immunol"},{"key":"8368_CR477","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1084\/jem.20020781","volume":"196","author":"FP Polack","year":"2002","unstructured":"Polack FP, Teng MN, Collins PL et al (2002) A role for immune complexes in enhanced respiratory syncytial virus disease. J Exp Med 196:859\u2013865","journal-title":"J Exp Med"},{"key":"8368_CR478","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0264-410X(98)80123-0","volume":"16","author":"LJ Gershwin","year":"1998","unstructured":"Gershwin LJ, Schelegle ES, Gunther RA et al (1998) A bovine model of vaccine enhanced respiratory syncytial virus pathophysiology. Vaccine 16:1225\u20131236","journal-title":"Vaccine"},{"key":"8368_CR479","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.cll.2009.07.004","volume":"29","author":"Y Murata","year":"2009","unstructured":"Murata Y (2009) Respiratory syncytial virus vaccine development. Clin Lab Med 29:725\u2013739","journal-title":"Clin Lab Med"},{"key":"8368_CR480","doi-asserted-by":"crossref","first-page":"582","DOI":"10.4161\/hv.9131","volume":"5","author":"JH Schickli","year":"2009","unstructured":"Schickli JH, Dubovsky F, Tang RS (2009) Challenges in developing a pediatric RSV vaccine. Hum Vaccin 5:582\u2013591","journal-title":"Hum Vaccin"},{"key":"8368_CR481","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.vaccine.2003.10.024","volume":"22","author":"WV Kalina","year":"2004","unstructured":"Kalina WV, Woolums AR, Berghaus RD, Gershwin LJ (2004) Formalin-inactivated bovine RSV vaccine enhances a Th2 mediated immune response in infected cattle. Vaccine 22:1465\u20131474","journal-title":"Vaccine"},{"key":"8368_CR482","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1086\/315859","volume":"182","author":"PF Wright","year":"2000","unstructured":"Wright PF, Karron RA, Belshe RB et al (2000) Evaluation of a live, cold-passaged, temperature-sensitive, respiratory syncytial virus vaccine candidate in infancy. J Infect Dis 182:1331\u20131342","journal-title":"J Infect Dis"},{"key":"8368_CR483","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1743-422X-7-114","volume":"7","author":"MN Widjojoatmodjo","year":"2010","unstructured":"Widjojoatmodjo MN, Boes J, van Bers M, van Remmerden Y, Roholl PJ, Luytjes W (2010) A highly attenuated recombinant human respiratory syncytial virus lacking the G protein induces long-lasting protection in cotton rats. Virol J 7:114","journal-title":"Virol J"},{"key":"8368_CR484","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1073\/pnas.96.5.2367","volume":"96","author":"A Bukreyev","year":"1999","unstructured":"Bukreyev A, Whitehead SS, Bukreyeva N, Murphy BR, Collins PL (1999) Interferon gamma expressed by a recombinant respiratory syncytial virus attenuates virus replication in mice without compromising immunogenicity. Proc Natl Acad Sci U S A 96:2367\u20132372","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8368_CR485","doi-asserted-by":"crossref","first-page":"5206","DOI":"10.1016\/j.vaccine.2012.06.011","volume":"30","author":"S Garlapati","year":"2012","unstructured":"Garlapati S, Garg R, Brownlie R et al (2012) Enhanced immune responses and protection by vaccination with respiratory syncytial virus fusion protein formulated with CpG oligodeoxynucleotide and innate defense regulator peptide in polyphosphazene microparticles. Vaccine 30:5206\u20135214","journal-title":"Vaccine"},{"key":"8368_CR486","doi-asserted-by":"crossref","first-page":"e34331","DOI":"10.1371\/journal.pone.0034331","volume":"7","author":"TN Nguyen","year":"2012","unstructured":"Nguyen TN, Power UF, Robert A et al (2012) The respiratory syncytial virus G protein conserved domain induces a persistent and protective antibody response in rodents. PLoS One 7:e34331","journal-title":"PLoS One"},{"key":"8368_CR487","doi-asserted-by":"crossref","first-page":"e25500","DOI":"10.1371\/journal.pone.0025500","volume":"6","author":"HY Shao","year":"2011","unstructured":"Shao HY, Lin YW, Yu SL et al (2011) Immunoprotectivity of HLA-A2 CTL peptides derived from respiratory syncytial virus fusion protein in HLA-A2 transgenic mouse. PLoS One 6:e25500","journal-title":"PLoS One"},{"key":"8368_CR488","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.vaccine.2011.11.054","volume":"30","author":"M Shafique","year":"2012","unstructured":"Shafique M, Wilschut J, de Haan A (2012) Induction of mucosal and systemic immunity against respiratory syncytial virus by inactivated virus supplemented with TLR9 and NOD2 ligands. Vaccine 30:597\u2013606","journal-title":"Vaccine"},{"key":"8368_CR489","doi-asserted-by":"crossref","first-page":"e21823","DOI":"10.1371\/journal.pone.0021823","volume":"6","author":"DM Lindell","year":"2011","unstructured":"Lindell DM, Morris SB, White MP et al (2011) A novel inactivated intranasal respiratory syncytial virus vaccine promotes viral clearance without Th2 associated vaccine-enhanced disease. PLoS One 6:e21823","journal-title":"PLoS One"},{"key":"8368_CR490","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/INF.0b013e31823386f1","volume":"31","author":"DI Bernstein","year":"2012","unstructured":"Bernstein DI, Malkin E, Abughali N, Falloon J, Yi T, Dubovsky F (2012) Phase 1 study of the safety and immunogenicity of a live, attenuated respiratory syncytial virus and parainfluenza virus type 3 vaccine in seronegative children. Pediatr Infect Dis J 31:109\u2013114","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR491","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0022-3476(99)70085-5","volume":"135","author":"MW Weber","year":"1999","unstructured":"Weber MW, Milligan P, Giadom B et al (1999) Respiratory illness after severe respiratory syncytial virus disease in infancy in The Gambia. J Pediatr 135:683\u2013688","journal-title":"J Pediatr"},{"key":"8368_CR492","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1183\/09031936.02.00103602","volume":"19","author":"WH Oddy","year":"2002","unstructured":"Oddy WH, de Klerk NH, Sly PD, Holt PG (2002) The effects of respiratory infections, atopy, and breastfeeding on childhood asthma. Eur Respir J 19:899\u2013905","journal-title":"Eur Respir J"},{"key":"8368_CR493","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1017\/S0950268808000666","volume":"137","author":"G Cilla","year":"2009","unstructured":"Cilla G, Onate E, Perez-Yarza EG, Montes M, Vicente D, Perez-Trallero E (2009) Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain. Epidemiol Infect 137:66\u201372","journal-title":"Epidemiol Infect"},{"key":"8368_CR494","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1097\/INF.0b013e3181e9de24","volume":"29","author":"SS Chiu","year":"2010","unstructured":"Chiu SS, Chan KH, Chen H et al (2010) Virologically confirmed population-based burden of hospitalization caused by respiratory syncytial virus, adenovirus, and parainfluenza viruses in children in Hong Kong. Pediatr Infect Dis J 29:1088\u20131092","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR495","first-page":"508","volume":"53","author":"N Hatipoglu","year":"2011","unstructured":"Hatipoglu N, Somer A, Badur S et al (2011) Viral etiology in hospitalized children with acute lower respiratory tract infection. Turk J Pediatr 53:508\u2013516","journal-title":"Turk J Pediatr"},{"key":"8368_CR496","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1097\/INF.0b013e3182566005","volume":"31","author":"C Laurent","year":"2012","unstructured":"Laurent C, Dugue AE, Brouard J et al (2012) Viral epidemiology and severity of respiratory infections in infants in 2009: a prospective study. Pediatr Infect Dis J 31:827\u2013831","journal-title":"Pediatr Infect Dis J"},{"key":"8368_CR497","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0165-2427(89)90077-9","volume":"20","author":"RS Stewart","year":"1989","unstructured":"Stewart RS, Gershwin LJ (1989) Detection of IgE antibodies to bovine respiratory syncytial virus. Vet Immunol Immunopathol 20:313\u2013323","journal-title":"Vet Immunol Immunopathol"}],"container-title":["Clinical Reviews in Allergy &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-013-8368-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12016-013-8368-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-013-8368-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-013-8368-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T04:15:41Z","timestamp":1744172141000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12016-013-8368-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,12]]},"references-count":497,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["8368"],"URL":"https:\/\/doi.org\/10.1007\/s12016-013-8368-9","relation":{},"ISSN":["1080-0549","1559-0267"],"issn-type":[{"value":"1080-0549","type":"print"},{"value":"1559-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,12]]},"assertion":[{"value":"12 April 2013","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}