{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:04:33Z","timestamp":1791324273168,"version":"4.3.1"},"reference-count":136,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T00:00:00Z","timestamp":1437523200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clinic Rev Allerg Immunol"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1007\/s12016-015-8501-z","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T02:15:01Z","timestamp":1437444901000},"page":"159-174","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Eosinophilic Esophagitis: A Comprehensive Review"],"prefix":"10.1007","volume":"50","author":[{"given":"Antonella","family":"Cianferoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Spergel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,22]]},"reference":[{"key":"8501_CR1","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1053\/j.gastro.2007.08.017","volume":"133","author":"GT Furuta","year":"2007","unstructured":"Furuta GT, Liacouras CA, Collins MH et al (2007) Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology 133:1342\u20131363","journal-title":"Gastroenterology"},{"key":"8501_CR2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2011.02.040","volume":"128","author":"CA Liacouras","year":"2011","unstructured":"Liacouras CA, Furuta GT, Hirano I (2011) Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol 128:3\u201320, e26","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR3","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.cgh.2009.06.023","volume":"7","author":"GA Prasad","year":"2009","unstructured":"Prasad GA, Alexander JA, Schleck CD et al (2009) Epidemiology of eosinophilic esophagitis over three decades in Olmsted County, Minnesota. Clin Gastroenterol Hepatol 7:1055\u20131061","journal-title":"Clin Gastroenterol Hepatol"},{"key":"8501_CR4","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1056\/NEJM200408263510924","volume":"351","author":"RJ Noel","year":"2004","unstructured":"Noel RJ, Putnam PE, Rothenberg ME (2004) Eosinophilic esophagitis. N Engl J Med 351:940\u2013941","journal-title":"N Engl J Med"},{"key":"8501_CR5","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jaci.2004.11.006","volume":"115","author":"A Straumann","year":"2005","unstructured":"Straumann A, Simon HU (2005) Eosinophilic esophagitis: escalating epidemiology? J Allergy Clin Immunol 115:418\u2013419","journal-title":"J Allergy Clin Immunol"},{"issue":"1349\u20131350","key":"8501_CR6","first-page":"e1345","volume":"128","author":"P Hruz","year":"2011","unstructured":"Hruz P, Straumann A, Bussmann C et al (2011) Escalating incidence of eosinophilic esophagitis: a 20-year prospective, population-based study in Olten County, Switzerland. J Allergy Clin Immunol 128(1349\u20131350):e1345","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR7","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1136\/adc.2006.100974","volume":"91","author":"S Cherian","year":"2006","unstructured":"Cherian S, Smith NM, Forbes DA (2006) Rapidly increasing prevalence of eosinophilic oesophagitis in Western Australia. Arch Dis Child 91:1000\u20131004","journal-title":"Arch Dis Child"},{"key":"8501_CR8","doi-asserted-by":"crossref","unstructured":"van Rhijn BD., Verheij J., Smout AJ. and Bredenoord AJ. (2012) Rapidly increasing incidence of eosinophilic esophagitis in a large cohort. Neurogastroenterol Motil","DOI":"10.1111\/nmo.12009"},{"key":"8501_CR9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/MPG.0b013e3181788282","volume":"48","author":"JM Spergel","year":"2009","unstructured":"Spergel JM, Brown-Whitehorn TF, Beausoleil JL et al (2009) 14 years of eosinophilic esophagitis: clinical features and prognosis. J Pediatr Gastroenterol Nutr 48:30\u201336","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"461\u2013467","key":"8501_CR10","first-page":"e465","volume":"130","author":"JM Spergel","year":"2012","unstructured":"Spergel JM, Brown-Whitehorn TF, Cianferoni A et al (2012) Identification of causative foods in children with eosinophilic esophagitis treated with an elimination diet. J Allergy Clin Immunol 130(461\u2013467):e465","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR11","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1111\/j.1572-0241.2000.02073.x","volume":"95","author":"SR Orenstein","year":"2000","unstructured":"Orenstein SR, Shalaby TM, Di Lorenzo C et al (2000) The spectrum of pediatric eosinophilic esophagitis beyond infancy: a clinical series of 30 children. Am J Gastroenterol 95:1422\u20131430","journal-title":"Am J Gastroenterol"},{"key":"8501_CR12","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.jaci.2006.07.038","volume":"118","author":"C Blanchard","year":"2006","unstructured":"Blanchard C, Wang N, Rothenberg ME (2006) Eosinophilic esophagitis: pathogenesis, genetics, and therapy. J Allergy Clin Immunol 118:1054\u20131059","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR13","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1172\/JCI26679","volume":"116","author":"C Blanchard","year":"2006","unstructured":"Blanchard C, Wang N, Stringer KF et al (2006) Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. J Clin Invest 116:536\u2013547","journal-title":"J Clin Invest"},{"key":"8501_CR14","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/01.mpg.0000188740.38757.d2","volume":"42","author":"SK Gupta","year":"2006","unstructured":"Gupta SK, Fitzgerald JF, Kondratyuk T, HogenEsch H (2006) Cytokine expression in normal and inflamed esophageal mucosa: a study into the pathogenesis of allergic eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 42:22\u201326","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"8501_CR15","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1067\/mai.2001.119917","volume":"108","author":"A Straumann","year":"2001","unstructured":"Straumann A, Bauer M, Fischer B, Blaser K, Simon HU (2001) Idiopathic eosinophilic esophagitis is associated with a T (H)2-type allergic inflammatory response. J Allergy Clin Immunol 108:954\u2013961","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR16","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1097\/01.MIB.0000172557.39767.53","volume":"11","author":"A Straumann","year":"2005","unstructured":"Straumann A, Kristl J, Conus S et al (2005) Cytokine expression in healthy and inflamed mucosa: probing the role of eosinophils in the digestive tract. Inflamm Bowel Dis 11:720\u2013726","journal-title":"Inflamm Bowel Dis"},{"key":"8501_CR17","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.jaci.2007.10.024","volume":"120","author":"C Blanchard","year":"2007","unstructured":"Blanchard C, Mingler MK, Vicario M et al (2007) IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids. J Allergy Clin Immunol 120:1292\u20131300","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR18","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/j.1365-2222.2005.02299.x","volume":"35","author":"C Blanchard","year":"2005","unstructured":"Blanchard C, Mishra A, Saito-Akei H, Monk P, Anderson I, Rothenberg ME (2005) Inhibition of human interleukin-13-induced respiratory and oesophageal inflammation by anti-human-interleukin-13 antibody (CAT-354). Clin Exp Allergy 35:1096\u20131103","journal-title":"Clin Exp Allergy"},{"key":"8501_CR19","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.4049\/jimmunol.0903069","volume":"184","author":"C Blanchard","year":"2010","unstructured":"Blanchard C, Stucke EM, Burwinkel K et al (2010) Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis. J Immunol 184:4033\u20134041","journal-title":"J Immunol"},{"key":"8501_CR20","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.4049\/jimmunol.168.5.2464","volume":"168","author":"A Mishra","year":"2002","unstructured":"Mishra A, Hogan SP, Brandt EB, Rothenberg ME (2002) IL-5 promotes eosinophil trafficking to the esophagus. J Immunol 168:2464\u20132469","journal-title":"J Immunol"},{"key":"8501_CR21","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.gastro.2003.07.007","volume":"125","author":"A Mishra","year":"2003","unstructured":"Mishra A, Rothenberg ME (2003) Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism. Gastroenterology 125:1419\u20131427","journal-title":"Gastroenterology"},{"key":"8501_CR22","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.4049\/jimmunol.169.2.1021","volume":"169","author":"P Schmid-Grendelmeier","year":"2002","unstructured":"Schmid-Grendelmeier P, Altznauer F, Fischer B et al (2002) Eosinophils express functional IL-13 in eosinophilic inflammatory diseases. J Immunol 169:1021\u20131027","journal-title":"J Immunol"},{"key":"8501_CR23","doi-asserted-by":"crossref","first-page":"p26","DOI":"10.1186\/2045-7022-1-S1-P26","volume":"1","author":"M Levin","year":"2011","unstructured":"Levin M, Motala C (2011) Eosinophilic esophagitis in Cape Town, South Africa. Clin Translat Allerg 1:p26","journal-title":"Clin Translat Allerg"},{"key":"8501_CR24","unstructured":"Dellon ES, Jensen ET, Martin CF, Shaheen NJ. and Kappelman MD. (2013) Prevalence of eosinophilic esophagitis in the United States. Clin Gastroenterol Hepatol"},{"key":"8501_CR25","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.cgh.2008.10.006","volume":"7","author":"JP Franciosi","year":"2009","unstructured":"Franciosi JP, Tam V, Liacouras CA, Spergel JM (2009) A case\u2013control study of sociodemographic and geographic characteristics of 335 children with eosinophilic esophagitis. Clin Gastroenterol Hepatol 7:415\u2013419","journal-title":"Clin Gastroenterol Hepatol"},{"key":"8501_CR26","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S1081-1206(10)61151-9","volume":"95","author":"JM Spergel","year":"2005","unstructured":"Spergel JM, Andrews T, Brown-Whitehorn TF, Beausoleil JL, Liacouras CA (2005) Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests. Ann Allergy Asthma Immunol 95:336\u2013343","journal-title":"Ann Allergy Asthma Immunol"},{"key":"8501_CR27","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.giec.2007.09.014","volume":"18","author":"MH Collins","year":"2008","unstructured":"Collins MH (2008) Histopathologic features of eosinophilic esophagitis. Gastrointest Endosc Clin N Am 18:59\u201371, viii-ix","journal-title":"Gastrointest Endosc Clin N Am"},{"key":"8501_CR28","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/ajg.2013.71","volume":"108","author":"ES Dellon","year":"2013","unstructured":"Dellon ES, Gonsalves N, Hirano I et al (2013) ACG clinical guideline: evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE). Am J Gastroenterol 108:679\u2013692, quiz 693","journal-title":"Am J Gastroenterol"},{"key":"8501_CR29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ng.547","volume":"42","author":"ME Rothenberg","year":"2010","unstructured":"Rothenberg ME, Spergel JM, Sherrill JD et al (2010) Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat Genet 42:289\u2013291","journal-title":"Nat Genet"},{"issue":"160\u2013165","key":"8501_CR30","first-page":"e163","volume":"126","author":"JD Sherrill","year":"2010","unstructured":"Sherrill JD, Gao PS, Stucke EM et al (2010) Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis. J Allergy Clin Immunol 126(160\u2013165):e163","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR31","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jaci.2010.10.039","volume":"127","author":"C Blanchard","year":"2011","unstructured":"Blanchard C, Stucke EM, Rodriguez-Jimenez B (2011) A striking local esophageal cytokine expression profile in eosinophilic esophagitis. J Allergy Clin Immunol 127:208\u2013217, 217 e201-207","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR32","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1159\/000341421","volume":"86","author":"Y Kinoshita","year":"2012","unstructured":"Kinoshita Y, Furuta K, Ishimura N, Ishihara S (2012) Elevated plasma cytokines in Japanese patients with eosinophilic esophagitis and gastroenteritis. Digestion 86:238\u2013243","journal-title":"Digestion"},{"key":"8501_CR33","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1053\/j.gastro.2005.06.027","volume":"129","author":"HS Akei","year":"2005","unstructured":"Akei HS, Mishra A, Blanchard C, Rothenberg ME (2005) Epicutaneous antigen exposure primes for experimental eosinophilic esophagitis in mice. Gastroenterology 129:985\u2013994","journal-title":"Gastroenterology"},{"key":"8501_CR34","doi-asserted-by":"crossref","unstructured":"Merves J, Muir A., Modayur Chandramouleeswaran P, Cianferoni A., Wang ML. and Spergel JM. (2014) Eosinophilic esophagitis. Ann Allergy Asthma Immunol","DOI":"10.1016\/j.anai.2014.01.023"},{"key":"8501_CR35","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.yexcr.2012.12.002","volume":"319","author":"AB Muir","year":"2013","unstructured":"Muir AB, Lim DM, Benitez AJ et al (2013) Esophageal epithelial and mesenchymal cross-talk leads to features of epithelial to mesenchymal transition in vitro. Exp Cell Res 319:850\u2013859","journal-title":"Exp Cell Res"},{"key":"8501_CR36","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1164\/ajrccm.160.3.9812110","volume":"160","author":"SE Wenzel","year":"1999","unstructured":"Wenzel SE, Schwartz LB, Langmack EL et al (1999) Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 160:1001\u20131008","journal-title":"Am J Respir Crit Care Med"},{"key":"8501_CR37","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1053\/j.gastro.2007.10.002","volume":"134","author":"A Mishra","year":"2008","unstructured":"Mishra A, Wang M, Pemmaraju VR et al (2008) Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia. Gastroenterology 134:204\u2013214","journal-title":"Gastroenterology"},{"key":"8501_CR38","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1067\/mai.2001.118600","volume":"108","author":"SM Pope","year":"2001","unstructured":"Pope SM, Brandt EB, Mishra A et al (2001) IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism. J Allergy Clin Immunol 108:594\u2013601","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR39","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.1074\/jbc.M110424200","volume":"277","author":"A Mishra","year":"2002","unstructured":"Mishra A, Hogan SP, Brandt EB et al (2002) Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking. J Biol Chem 277:4406\u20134412","journal-title":"J Biol Chem"},{"key":"8501_CR40","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jaci.2011.11.044","volume":"129","author":"JM Spergel","year":"2012","unstructured":"Spergel JM, Rothenberg ME, Collins MH (2012) Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol 129:456\u2013463, 463 e451-453","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR41","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1053\/j.gastro.2011.07.044","volume":"141","author":"AH Assa\u2019ad","year":"2011","unstructured":"Assa\u2019ad AH, Gupta SK, Collins MH et al (2011) An antibody against IL-5 reduces numbers of esophageal intraepithelial eosinophils in children with eosinophilic esophagitis. Gastroenterology 141:1593\u20131604","journal-title":"Gastroenterology"},{"key":"8501_CR42","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/jid.2008.232","volume":"129","author":"M Li","year":"2009","unstructured":"Li M, Hener P, Zhang Z, Ganti KP, Metzger D, Chambon P (2009) Induction of thymic stromal lymphopoietin expression in keratinocytes is necessary for generating an atopic dermatitis upon application of the active vitamin D3 analogue MC903 on mouse skin. J Invest Dermatol 129:498\u2013502","journal-title":"J Invest Dermatol"},{"key":"8501_CR43","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrm910","volume":"3","author":"V Soumelis","year":"2002","unstructured":"Soumelis V, Reche PA, Kanzler H et al (2002) Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol 3:673\u2013680","journal-title":"Nat Immunol"},{"key":"8501_CR44","doi-asserted-by":"crossref","unstructured":"Noti M., Wojno ED., Kim BS., et al. (2013) Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis. Nat Med","DOI":"10.1038\/nm.3281"},{"key":"8501_CR45","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.jaci.2013.07.046","volume":"132","author":"MC Siracusa","year":"2013","unstructured":"Siracusa MC, Kim BS, Spergel JM, Artis D (2013) Basophils and allergic inflammation. J Allergy Clin Immunol 132:789\u2013801, quiz 788","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR46","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/nature10329","volume":"477","author":"MC Siracusa","year":"2011","unstructured":"Siracusa MC, Saenz SA, Hill DA et al (2011) TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. Nature 477:229\u2013233","journal-title":"Nature"},{"key":"8501_CR47","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.cyto.2013.06.285","volume":"63","author":"EDT Wojno","year":"2013","unstructured":"Wojno EDT, Noti M, Kim BS et al (2013) TSLP-elicited basophil responses mediate the pathogenesis of eosinophilic esophagitis. Cytokine 63:310\u2013310","journal-title":"Cytokine"},{"key":"8501_CR48","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/nm.3281","volume":"19","author":"M Noti","year":"2013","unstructured":"Noti M, Wojno ED, Kim BS et al (2013) Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis. Nat Med 19:1005\u20131013","journal-title":"Nat Med"},{"key":"8501_CR49","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1016\/j.biocel.2005.06.010","volume":"37","author":"C Blanchard","year":"2005","unstructured":"Blanchard C, Durual S, Estienne M, Emami S, Vasseur S, Cuber JC (2005) Eotaxin-3\/CCL26 gene expression in intestinal epithelial cells is up-regulated by interleukin-4 and interleukin-13 via the signal transducer and activator of transcription 6. Int J Biochem Cell Biol 37:2559\u20132573","journal-title":"Int J Biochem Cell Biol"},{"key":"8501_CR50","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1136\/gutjnl-2012-302250","volume":"62","author":"E Cheng","year":"2013","unstructured":"Cheng E, Zhang X, Huo X et al (2013) Omeprazole blocks eotaxin-3 expression by oesophageal squamous cells from patients with eosinophilic oesophagitis and GORD. Gut 62:824\u2013832","journal-title":"Gut"},{"key":"8501_CR51","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1159\/000331326","volume":"3","author":"M Johnsson","year":"2011","unstructured":"Johnsson M, Bove M, Bergquist H et al (2011) Distinctive blood eosinophilic phenotypes and cytokine patterns in eosinophilic esophagitis, inflammatory bowel disease and airway allergy. J Innate Immun 3:594\u2013604","journal-title":"J Innate Immun"},{"key":"8501_CR52","doi-asserted-by":"crossref","unstructured":"Sherrill J. D., Kc K., Wu D., et al. (2013) Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis. Mucosal Immunol","DOI":"10.1038\/mi.2013.90"},{"key":"8501_CR53","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1053\/j.gastro.2013.08.046","volume":"145","author":"T Wen","year":"2013","unstructured":"Wen T, Stucke EM, Grotjan TM et al (2013) Molecular diagnosis of eosinophilic esophagitis by gene expression profiling. Gastroenterology 145:1289\u20131299","journal-title":"Gastroenterology"},{"key":"8501_CR54","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/MPG.0b013e3181de7685","volume":"51","author":"EH Yen","year":"2010","unstructured":"Yen EH, Hornick JL, Dehlink E et al (2010) Comparative analysis of FcepsilonRI expression patterns in patients with eosinophilic and reflux esophagitis. J Pediatr Gastroenterol Nutr 51:584\u2013592","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"8501_CR55","doi-asserted-by":"crossref","first-page":"G1172","DOI":"10.1152\/ajpgi.00065.2009","volume":"297","author":"DM Lim","year":"2009","unstructured":"Lim DM, Narasimhan S, Michaylira CZ, Wang ML (2009) TLR3-mediated NF-{kappa}B signaling in human esophageal epithelial cells. Am J Physiol Gastrointest Liver Physiol 297:G1172\u2013G1180","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"8501_CR56","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1007\/s10620-011-1907-4","volume":"57","author":"DJ Mulder","year":"2012","unstructured":"Mulder DJ, Lobo D, Mak N, Justinich CJ (2012) Expression of toll-like receptors 2 and 3 on esophageal epithelial cell lines and on eosinophils during esophagitis. Dig Dis Sci 57:630\u2013642","journal-title":"Dig Dis Sci"},{"key":"8501_CR57","doi-asserted-by":"crossref","unstructured":"Jyonouchi S., Smith CL., Saretta F., et al. (2013) Invariant natural killer T cells in children with eosinophilic esophagitis. Clin Exp Allergy","DOI":"10.1111\/cea.12201"},{"key":"8501_CR58","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.ajpath.2010.10.027","volume":"178","author":"DJ Mulder","year":"2011","unstructured":"Mulder DJ, Pooni A, Mak N, Hurlbut DJ, Basta S, Justinich CJ (2011) Antigen presentation and MHC class II expression by human esophageal epithelial cells: role in eosinophilic esophagitis. Am J Pathol 178:744\u2013753","journal-title":"Am J Pathol"},{"key":"8501_CR59","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1136\/gut.2009.178558","volume":"59","author":"A Straumann","year":"2010","unstructured":"Straumann A, Conus S, Grzonka P et al (2010) Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial. Gut 59:21\u201330","journal-title":"Gut"},{"key":"8501_CR60","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jaci.2011.11.044","volume":"129","author":"JM Spergel","year":"2012","unstructured":"Spergel JM, Rothenberg ME, Collins MH (2012) Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol 129:456\u2013463, 463 e451-453","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR61","doi-asserted-by":"crossref","first-page":"G645","DOI":"10.1152\/ajpgi.00223.2011","volume":"302","author":"P Rajavelu","year":"2012","unstructured":"Rajavelu P, Rayapudi M, Moffitt M, Mishra A, Mishra A (2012) Significance of para-esophageal lymph nodes in food or aeroallergen-induced iNKT cell-mediated experimental eosinophilic esophagitis. Am J Physiol Gastrointest Liver Physiol 302:G645\u2013G654","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"8501_CR62","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1189\/jlb.1106653","volume":"81","author":"A Mishra","year":"2007","unstructured":"Mishra A, Schlotman J, Wang M, Rothenberg ME (2007) Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in mice. J Leukoc Biol 81:916\u2013924","journal-title":"J Leukoc Biol"},{"key":"8501_CR63","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1007\/s10620-005-9048-2","volume":"51","author":"K Yamazaki","year":"2006","unstructured":"Yamazaki K, Murray JA, Arora AS et al (2006) Allergen-specific in vitro cytokine production in adult patients with eosinophilic esophagitis. Dig Dis Sci 51:1934\u20131941","journal-title":"Dig Dis Sci"},{"key":"8501_CR64","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jaci.2010.04.009","volume":"126","author":"JP Abonia","year":"2010","unstructured":"Abonia JP, Blanchard C, Butz BB et al (2010) Involvement of mast cells in eosinophilic esophagitis. J Allergy Clin Immunol 126:140\u2013149","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR65","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1442-2050.2012.01344.x","volume":"26","author":"SD Crockett","year":"2013","unstructured":"Crockett SD, Sperry SL, Miller CB, Shaheen NJ, Dellon ES (2013) Emergency care of esophageal foreign body impactions: timing, treatment modalities, and resource utilization. Dis Esophagus 26:105\u2013112","journal-title":"Dis Esophagus"},{"key":"8501_CR66","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0016-5107(05)00313-5","volume":"61","author":"TK Desai","year":"2005","unstructured":"Desai TK, Stecevic V, Chang CH, Goldstein NS, Badizadegan K, Furuta GT (2005) Association of eosinophilic inflammation with esophageal food impaction in adults. Gastrointest Endosc 61:795\u2013801","journal-title":"Gastrointest Endosc"},{"key":"8501_CR67","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.iac.2008.10.003","volume":"29","author":"SS Aceves","year":"2009","unstructured":"Aceves SS, Ackerman SJ (2009) Relationships between eosinophilic inflammation, tissue remodeling, and fibrosis in eosinophilic esophagitis. Immunol Allergy Clin North Am 29:197\u2013211, xiii-xiv","journal-title":"Immunol Allergy Clin North Am"},{"key":"8501_CR68","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nrm809","volume":"3","author":"JJ Tomasek","year":"2002","unstructured":"Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA (2002) Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 3:349\u2013363","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1387\u20131396","key":"8501_CR69","doi-asserted-by":"crossref","first-page":"e1387","DOI":"10.1016\/j.jaci.2012.03.005","volume":"129","author":"AF Kagalwalla","year":"2012","unstructured":"Kagalwalla AF, Akhtar N, Woodruff SA et al (2012) Eosinophilic esophagitis: epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment. J Allergy Clin Immunol 129(1387\u20131396):e1387","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR70","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1398-9995.2009.02142.x","volume":"65","author":"SS Aceves","year":"2010","unstructured":"Aceves SS, Newbury RO, Chen D et al (2010) Resolution of remodeling in eosinophilic esophagitis correlates with epithelial response to topical corticosteroids. Allergy 65:109\u2013116","journal-title":"Allergy"},{"key":"8501_CR71","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jaci.2006.10.016","volume":"119","author":"SS Aceves","year":"2007","unstructured":"Aceves SS, Newbury RO, Dohil R, Bastian JF, Broide DH (2007) Esophageal remodeling in pediatric eosinophilic esophagitis. J Allergy Clin Immunol 119:206\u2013212","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR72","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/ng.3033","volume":"46","author":"LC Kottyan","year":"2014","unstructured":"Kottyan LC, Davis BP, Sherrill JD et al (2014) Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease. Nat Genet 46:895\u2013900","journal-title":"Nat Genet"},{"key":"8501_CR73","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1182\/blood-2009-05-219584","volume":"114","author":"G Lal","year":"2009","unstructured":"Lal G, Bromberg JS (2009) Epigenetic mechanisms of regulation of Foxp3 expression. Blood 114:3727\u20133735","journal-title":"Blood"},{"key":"8501_CR74","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1182\/blood-2013-02-486944","volume":"123","author":"C Schmidl","year":"2014","unstructured":"Schmidl C, Hansmann L, Lassmann T et al (2014) The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations. Blood 123:e68\u2013e78","journal-title":"Blood"},{"key":"8501_CR75","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/imm.12198","volume":"141","author":"H He","year":"2014","unstructured":"He H, Ni B, Tian Y et al (2014) Histone methylation mediates plasticity of human FOXP3(+) regulatory T cells by modulating signature gene expressions. Immunology 141:362\u2013376","journal-title":"Immunology"},{"key":"8501_CR76","doi-asserted-by":"crossref","first-page":"e27770","DOI":"10.1371\/journal.pone.0027770","volume":"6","author":"Y Tian","year":"2011","unstructured":"Tian Y, Jia Z, Wang J et al (2011) Global mapping of H3K4me1 and H3K4me3 reveals the chromatin state-based cell type-specific gene regulation in human Treg cells. PLoS One 6:e27770","journal-title":"PLoS One"},{"key":"8501_CR77","doi-asserted-by":"crossref","first-page":"13193","DOI":"10.1074\/jbc.M110.210724","volume":"286","author":"EJ Lim","year":"2011","unstructured":"Lim EJ, Lu TX, Blanchard C, Rothenberg ME (2011) Epigenetic regulation of the IL-13-induced human eotaxin-3 gene by CREB-binding protein-mediated histone 3 acetylation. J Biol Chem 286:13193\u201313204","journal-title":"J Biol Chem"},{"key":"8501_CR78","doi-asserted-by":"crossref","first-page":"e50037","DOI":"10.1371\/journal.pone.0050037","volume":"7","author":"X Zhang","year":"2012","unstructured":"Zhang X, Cheng E, Huo X et al (2012) Omeprazole blocks STAT6 binding to the eotaxin-3 promoter in eosinophilic esophagitis cells. PLoS One 7:e50037","journal-title":"PLoS One"},{"key":"8501_CR79","doi-asserted-by":"crossref","first-page":"466","DOI":"10.4049\/jimmunol.1302454","volume":"192","author":"E Lim","year":"2014","unstructured":"Lim E, Rothenberg ME (2014) Demethylation of the human eotaxin-3 gene promoter leads to the elevated expression of eotaxin-3. J Immunol 192:466\u2013474","journal-title":"J Immunol"},{"key":"8501_CR80","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2013.04.039","volume":"132","author":"TX Lu","year":"2013","unstructured":"Lu TX, Rothenberg ME (2013) Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases. J Allergy Clin Immunol 132:3\u201313","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR81","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/0016-5085(95)90637-1","volume":"109","author":"KJ Kelly","year":"1995","unstructured":"Kelly KJ, Lazenby AJ, Rowe PC, Yardley JH, Perman JA, Sampson HA (1995) Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula. Gastroenterology 109:1503\u20131512","journal-title":"Gastroenterology"},{"key":"8501_CR82","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.cgh.2006.05.026","volume":"4","author":"AF Kagalwalla","year":"2006","unstructured":"Kagalwalla AF, Sentongo TA, Ritz S et al (2006) Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis. Clin Gastroenterol Hepatol 4:1097\u20131102","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"75\u201391","key":"8501_CR83","first-page":"vi","volume":"36","author":"N Gonsalves","year":"2007","unstructured":"Gonsalves N (2007) Food allergies and eosinophilic gastrointestinal illness. Gastroenterol Clin North Am 36(75\u201391):vi","journal-title":"Gastroenterol Clin North Am"},{"key":"8501_CR84","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/MPG.0b013e31821cf503","volume":"53","author":"AF Kagalwalla","year":"2011","unstructured":"Kagalwalla AF, Shah A, Li BU et al (2011) Identification of specific foods responsible for inflammation in children with eosinophilic esophagitis successfully treated with empiric elimination diet. J Pediatr Gastroenterol Nutr 53:145\u2013149","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"8501_CR85","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/01.mcg.0000248019.16139.67","volume":"41","author":"FY Wang","year":"2007","unstructured":"Wang FY, Gupta SK, Fitzgerald JF (2007) Is there a seasonal variation in the incidence or intensity of allergic eosinophilic esophagitis in newly diagnosed children? J Clin Gastroenterol 41:451\u2013453","journal-title":"J Clin Gastroenterol"},{"key":"8501_CR86","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1111\/j.1398-9995.2007.01454.x","volume":"62","author":"KK Sugnanam","year":"2007","unstructured":"Sugnanam KK, Collins JT, Smith PK et al (2007) Dichotomy of food and inhalant allergen sensitization in eosinophilic esophagitis. Allergy 62:1257\u20131260","journal-title":"Allergy"},{"key":"8501_CR87","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1007\/s00431-011-1540-4","volume":"170","author":"R Rocha","year":"2011","unstructured":"Rocha R, Vitor AB, Trindade E et al (2011) Omalizumab in the treatment of eosinophilic esophagitis and food allergy. Euro J Pediatr 170:1471\u20131474","journal-title":"Euro J Pediatr"},{"key":"8501_CR88","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.jaci.2014.02.004","volume":"133","author":"SM Maggadottir","year":"2014","unstructured":"Maggadottir SM, Hill DA, Ruymann K (2014) Resolution of acute IgE-mediated allergy with development of eosinophilic esophagitis triggered by the same food. J Allergy Clin Immunol 133:1487\u20131489, 1489 e1481","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR89","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.anai.2010.10.010","volume":"106","author":"E Ridolo","year":"2011","unstructured":"Ridolo E, De Angelis GL, Dall\u2019aglio P (2011) Eosinophilic esophagitis after specific oral tolerance induction for egg protein. Ann Allergy Asthma Immunol 106:73\u201374","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"3\u201320","key":"8501_CR90","first-page":"e26","volume":"128","author":"CA Liacouras","year":"2011","unstructured":"Liacouras CA, Furuta GT, Hirano I et al (2011) Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol 128(3\u201320):e26, quiz 21\u201322","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR91","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jaci.2012.06.051","volume":"130","author":"ME Rothenberg","year":"2012","unstructured":"Rothenberg ME, Aceves S, Bonis PA et al (2012) Working with the US Food and Drug Administration: progress and timelines in understanding and treating patients with eosinophilic esophagitis. J Allergy Clin Immunol 130:617\u2013619","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR92","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1053\/j.gastro.2012.03.001","volume":"142","author":"N Gonsalves","year":"2012","unstructured":"Gonsalves N, Yang GY, Doerfler B, Ritz S, Ditto AM, Hirano I (2012) Elimination diet effectively treats eosinophilic esophagitis in adults; food reintroduction identifies causative factors. Gastroenterology 142:1451\u20131459, e1451; quiz e1414-1455","journal-title":"Gastroenterology"},{"key":"8501_CR93","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S1542-3565(05)00885-2","volume":"3","author":"CA Liacouras","year":"2005","unstructured":"Liacouras CA, Spergel JM, Ruchelli E et al (2005) Eosinophilic esophagitis: a 10-year experience in 381 children. Clin Gastroenterol Hepatol 3:1198\u20131206","journal-title":"Clin Gastroenterol Hepatol"},{"key":"8501_CR94","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1053\/j.gastro.2006.08.033","volume":"131","author":"MR Konikoff","year":"2006","unstructured":"Konikoff MR, Noel RJ, Blanchard C et al (2006) A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis. Gastroenterology 131:1381\u20131391","journal-title":"Gastroenterology"},{"key":"8501_CR95","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S1542-3565(04)00240-X","volume":"2","author":"RJ Noel","year":"2004","unstructured":"Noel RJ, Putnam PE, Collins MH et al (2004) Clinical and immunopathologic effects of swallowed fluticasone for eosinophilic esophagitis. Clin Gastroenterol Hepatol 2:568\u2013575","journal-title":"Clin Gastroenterol Hepatol"},{"key":"8501_CR96","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1053\/gast.2002.32998","volume":"122","author":"JE Teitelbaum","year":"2002","unstructured":"Teitelbaum JE, Fox VL, Twarog FJ et al (2002) Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionate. Gastroenterology 122:1216\u20131225","journal-title":"Gastroenterology"},{"issue":"879\u2013888","key":"8501_CR97","first-page":"e878","volume":"125","author":"JM Caldwell","year":"2010","unstructured":"Caldwell JM, Blanchard C, Collins MH et al (2010) Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51. J Allergy Clin Immunol 125(879\u2013888):e878","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR98","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1111\/j.1572-0241.2007.01379.x","volume":"102","author":"SS Aceves","year":"2007","unstructured":"Aceves SS, Bastian JF, Newbury RO, Dohil R (2007) Oral viscous budesonide: a potential new therapy for eosinophilic esophagitis in children. Am J Gastroenterol 102:2271\u20132279, quiz 2280","journal-title":"Am J Gastroenterol"},{"key":"8501_CR99","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1053\/j.gastro.2010.05.001","volume":"139","author":"R Dohil","year":"2010","unstructured":"Dohil R, Newbury R, Fox L, Bastian J, Aceves S (2010) Oral viscous budesonide is effective in children with eosinophilic esophagitis in a randomized, placebo-controlled trial. Gastroenterology 139:418\u2013429","journal-title":"Gastroenterology"},{"key":"8501_CR100","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cgh.2007.11.008","volume":"6","author":"ET Schaefer","year":"2008","unstructured":"Schaefer ET, Fitzgerald JF, Molleston JP et al (2008) Comparison of oral prednisone and topical fluticasone in the treatment of eosinophilic esophagitis: a randomized trial in children. Clin Gastroenterol Hepatol 6:165\u2013173","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"742\u2013749","key":"8501_CR101","first-page":"e741","volume":"10","author":"JA Alexander","year":"2012","unstructured":"Alexander JA, Jung KW, Arora AS et al (2012) Swallowed fluticasone improves histologic but not symptomatic response of adults with eosinophilic esophagitis. Clin Gastroenterol Hepatol 10(742\u2013749):e741","journal-title":"Clin Gastroenterol Hepatol"},{"key":"8501_CR102","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1053\/j.gastro.2010.07.048","volume":"139","author":"A Straumann","year":"2010","unstructured":"Straumann A, Conus S, Degen L (2010) Budesonide is effective in adolescent and adult patients with active eosinophilic esophagitis. Gastroenterology 139:1526\u20131537, 1537 e1521","journal-title":"Gastroenterology"},{"issue":"321\u2013324","key":"8501_CR103","doi-asserted-by":"crossref","first-page":"e321","DOI":"10.1053\/j.gastro.2012.04.049","volume":"143","author":"ES Dellon","year":"2012","unstructured":"Dellon ES, Sheikh A, Speck O et al (2012) Viscous topical is more effective than nebulized steroid therapy for patients with eosinophilic esophagitis. Gastroenterology 143(321\u2013324):e321","journal-title":"Gastroenterology"},{"key":"8501_CR104","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jaci.2011.08.007","volume":"128","author":"AJ Lucendo","year":"2011","unstructured":"Lucendo AJ, Arias A, De Rezende LC et al (2011) Subepithelial collagen deposition, profibrogenic cytokine gene expression, and changes after prolonged fluticasone propionate treatment in adult eosinophilic esophagitis: a prospective study. J Allergy Clin Immunol 128:1037\u20131046","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR105","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1056\/NEJMoa1203229","volume":"367","author":"HW Kelly","year":"2012","unstructured":"Kelly HW, Sternberg AL, Lescher R et al (2012) Effect of inhaled glucocorticoids in childhood on adult height. N Engl J Med 367:904\u2013912","journal-title":"N Engl J Med"},{"key":"8501_CR106","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1203\/PDR.0b013e3181e69e36","volume":"68","author":"M Turpeinen","year":"2010","unstructured":"Turpeinen M, Pelkonen AS, Nikander K et al (2010) Bone mineral density in children treated with daily or periodical inhaled budesonide: the Helsinki Early Intervention Childhood Asthma study. Pediatr Res 68:169\u2013173","journal-title":"Pediatr Res"},{"key":"8501_CR107","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/ACI.0b013e32813aee4a","volume":"7","author":"JM Spergel","year":"2007","unstructured":"Spergel JM (2007) Eosinophilic esophagitis in adults and children: evidence for a food allergy component in many patients. Curr Opin Allergy Clin Immunol 7:274\u2013278","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"8501_CR108","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1067\/mai.2002.121458","volume":"109","author":"JM Spergel","year":"2002","unstructured":"Spergel JM, Beausoleil JL, Mascarenhas M, Liacouras CA (2002) The use of skin prick tests and patch tests to identify causative foods in eosinophilic esophagitis. J Allergy Clin Immunol 109:363\u2013368","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR109","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s11882-005-0061-5","volume":"5","author":"JM Spergel","year":"2005","unstructured":"Spergel JM, Brown-Whitehorn T (2005) The use of patch testing in the diagnosis of food allergy. Curr Allerg Asthma Rep 5:86\u201390","journal-title":"Curr Allerg Asthma Rep"},{"key":"8501_CR110","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jaci.2005.01.017","volume":"115","author":"D Simon","year":"2005","unstructured":"Simon D, Marti H, Heer P, Simon HU, Braathen LR, Straumann A (2005) Eosinophilic esophagitis is frequently associated with IgE-mediated allergic airway diseases. J Allergy Clin Immunol 115:1090\u20131092","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR111","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jaci.2006.11.016","volume":"119","author":"JM Spergel","year":"2007","unstructured":"Spergel JM, Brown-Whitehorn T, Beausoleil JL, Shuker M, Liacouras CA (2007) Predictive values for skin prick test and atopy patch test for eosinophilic esophagitis. J Allergy Clin Immunol 119:509\u2013511","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR112","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.jaci.2005.08.033","volume":"116","author":"N Kalach","year":"2005","unstructured":"Kalach N, Soulaines P, de Boissieu D, Dupont C (2005) A pilot study of the usefulness and safety of a ready-to-use atopy patch test (Diallertest) versus a comparator (Finn Chamber) during cow\u2019s milk allergy in children. J Allergy Clin Immunol 116:1321\u20131326","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR113","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0091-6749(96)70277-4","volume":"97","author":"E Isolauri","year":"1996","unstructured":"Isolauri E, Turjanmaa K (1996) Combined skin prick and patch testing enhances identification of food allergy in infants with atopic dermatitis. J Allergy Clin Immunol 97:9\u201315","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR114","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/j.1398-9995.1997.tb01234.x","volume":"52","author":"OM Kekki","year":"1997","unstructured":"Kekki OM, Turjanmaa K, Isolauri E (1997) Differences in skin-prick and patch-test reactivity are related to the heterogeneity of atopic eczema in infants. Allergy 52:755\u2013759","journal-title":"Allergy"},{"key":"8501_CR115","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1046\/j.0905-6157.2003.00086.x","volume":"15","author":"F Rance","year":"2004","unstructured":"Rance F (2004) What is the optimal occlusion time for the atopy patch test in the diagnosis of food allergies in children with atopic dermatitis? Pediatr Allergy Immunol 15:93\u201396","journal-title":"Pediatr Allergy Immunol"},{"key":"8501_CR116","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jaip.2013.05.009","volume":"1","author":"MJ Greenhawt","year":"2013","unstructured":"Greenhawt MJ, Aceves S, Spergel JM, Rothenberg ME (2013) The management of eosinophilic esophagitis. J Allergy Clin Immunol: In Practice 1:332\u2013340","journal-title":"J Allergy Clin Immunol: In Practice"},{"key":"8501_CR117","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.giec.2007.09.008","volume":"18","author":"JM Spergel","year":"2008","unstructured":"Spergel JM, Shuker M (2008) Nutritional management of eosinophilic esophagitis. Gastrointest Endosc Clin N Am 18:179\u2013194, xi","journal-title":"Gastrointest Endosc Clin N Am"},{"key":"8501_CR118","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1067\/mai.2001.116576","volume":"108","author":"TK Hart","year":"2001","unstructured":"Hart TK, Cook RM, Zia-Amirhosseini P et al (2001) Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys. J Allergy Clin Immunol 108:250\u2013257","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR119","first-page":"779","volume":"49","author":"RW Egan","year":"1999","unstructured":"Egan RW, Athwal D, Bodmer MW et al (1999) Effect of Sch 55700, a humanized monoclonal antibody to human interleukin-5, on eosinophilic responses and bronchial hyperreactivity. Arzneimittelforschung 49:779\u2013790","journal-title":"Arzneimittelforschung"},{"key":"8501_CR120","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jaci.2010.04.029","volume":"126","author":"S Conus","year":"2010","unstructured":"Conus S, Straumann A, Bettler E, Simon HU (2010) Mepolizumab does not alter levels of eosinophils, T cells, and mast cells in the duodenal mucosa in eosinophilic esophagitis. J Allergy Clin Immunol 126:175\u2013177","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR121","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jaci.2008.06.012","volume":"122","author":"A Straumann","year":"2008","unstructured":"Straumann A, Bussmann C, Conus S, Beglinger C, Simon HU (2008) Anti-TNF-alpha (infliximab) therapy for severe adult eosinophilic esophagitis. J Allergy Clin Immunol 122:425\u2013427","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR122","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1007\/s00431-011-1540-4","volume":"170","author":"R Rocha","year":"2011","unstructured":"Rocha R, Vitor AB, Trindade E et al (2011) Omalizumab in the treatment of eosinophilic esophagitis and food allergy. Eur J Pediatr 170:1471\u20131474","journal-title":"Eur J Pediatr"},{"key":"8501_CR123","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/all.12096","volume":"68","author":"A Straumann","year":"2013","unstructured":"Straumann A, Hoesli S, Bussmann C et al (2013) Anti-eosinophil activity and clinical efficacy of the CRTH2 antagonist OC000459 in eosinophilic esophagitis. Allergy 68:375\u2013385","journal-title":"Allergy"},{"key":"8501_CR124","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0091-6749(97)80006-1","volume":"99","author":"HS Nelson","year":"1997","unstructured":"Nelson HS, Lahr J, Rule R, Bock A, Leung D (1997) Treatment of anaphylactic sensitivity to peanuts by immunotherapy with injections of aqueous peanut extract. J Allergy Clin Immunol 99:744\u2013751","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR125","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jaci.2010.12.1098","volume":"127","author":"A Nowak-Wegrzyn","year":"2011","unstructured":"Nowak-Wegrzyn A, Sampson HA (2011) Future therapies for food allergies. J Allergy Clin Immunol 127:558\u2013573, quiz 574\u2013555","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR126","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jaci.2009.05.022","volume":"124","author":"SM Jones","year":"2009","unstructured":"Jones SM, Pons L, Roberts JL (2009) Clinical efficacy and immune regulation with peanut oral immunotherapy. J Allergy Clin Immunol 124:292\u2013300, 300 e291-297","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR127","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jaci.2006.09.016","volume":"119","author":"AD Buchanan","year":"2007","unstructured":"Buchanan AD, Green TD, Jones SM et al (2007) Egg oral immunotherapy in nonanaphylactic children with egg allergy. J Allergy Clin Immunol 119:199\u2013205","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR128","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1007\/s10620-006-9245-7","volume":"52","author":"G Patriarca","year":"2007","unstructured":"Patriarca G, Nucera E, Pollastrini E et al (2007) Oral specific desensitization in food-allergic children. Dig Dis Sci 52:1662\u20131672","journal-title":"Dig Dis Sci"},{"key":"8501_CR129","first-page":"52","volume":"45","author":"G Patriarca","year":"1998","unstructured":"Patriarca G, Schiavino D, Nucera E, Schinco G, Milani A, Gasbarrini GB (1998) Food allergy in children: results of a standardized protocol for oral desensitization. Hepatogastroenterology 45:52\u201358","journal-title":"Hepatogastroenterology"},{"key":"8501_CR130","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.jaci.2008.09.030","volume":"122","author":"JM Skripak","year":"2008","unstructured":"Skripak JM, Nash SD, Rowley H et al (2008) A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow\u2019s milk allergy. J Allergy Clin Immunol 122:1154\u20131160","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR131","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jaci.2009.03.045","volume":"124","author":"AM Hofmann","year":"2009","unstructured":"Hofmann AM, Scurlock AM, Jones SM (2009) Safety of a peanut oral immunotherapy protocol in children with peanut allergy. J Allergy Clin Immunol 124:286\u2013291, 291 e281-286","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR132","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.jaci.2009.06.025","volume":"124","author":"SD Narisety","year":"2009","unstructured":"Narisety SD, Skripak JM, Steele P et al (2009) Open-label maintenance after milk oral immunotherapy for IgE-mediated cow\u2019s milk allergy. J Allergy Clin Immunol 124:610\u2013612","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR133","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.jaci.2011.11.042","volume":"129","author":"S Sanchez-Garcia","year":"2012","unstructured":"Sanchez-Garcia S, Rodriguez Del Rio P, Escudero C, Martinez-Gomez MJ, Ibanez MD (2012) Possible eosinophilic esophagitis induced by milk oral immunotherapy. J Allergy Clin Immunol 129:1155\u20131157","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR134","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1111\/j.1365-2222.2005.02351.x","volume":"35","author":"K Onbasi","year":"2005","unstructured":"Onbasi K, Sin AZ, Doganavsargil B, Onder GF, Bor S, Sebik F (2005) Eosinophil infiltration of the oesophageal mucosa in patients with pollen allergy during the season. Clin Exp Allergy 35:1423\u20131431","journal-title":"Clin Exp Allergy"},{"issue":"600\u2013602","key":"8501_CR135","first-page":"e601","volume":"131","author":"L Swert De","year":"2013","unstructured":"De Swert L, Veereman G, Bublin M et al (2013) Eosinophilic gastrointestinal disease suggestive of pathogenesis-related class 10 (PR-10) protein allergy resolved after immunotherapy. J Allergy Clin Immunol 131(600\u2013602):e601\u2013e603","journal-title":"J Allergy Clin Immunol"},{"key":"8501_CR136","doi-asserted-by":"crossref","unstructured":"Ramirez R. M. and Jacobs RL. (2013) Eosinophilic esophagitis treated with immunotherapy to dust mites. J Allergy Clin Immunol","DOI":"10.1016\/j.jaci.2013.04.053"}],"container-title":["Clinical Reviews in Allergy &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-015-8501-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12016-015-8501-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-015-8501-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T13:47:14Z","timestamp":1567000034000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12016-015-8501-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,22]]},"references-count":136,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["8501"],"URL":"https:\/\/doi.org\/10.1007\/s12016-015-8501-z","relation":{},"ISSN":["1080-0549","1559-0267"],"issn-type":[{"value":"1080-0549","type":"print"},{"value":"1559-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,22]]}}}