{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T12:47:57Z","timestamp":1793969277822,"version":"4.8.0"},"reference-count":127,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clinic Rev Allerg Immunol"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1007\/s12016-018-8695-y","type":"journal-article","created":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T16:01:05Z","timestamp":1531411265000},"page":"194-212","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Gastrointestinal Manifestations of Hypereosinophilic Syndromes and Mast Cell Disorders: a Comprehensive Review"],"prefix":"10.1007","volume":"57","author":[{"given":"Vivian C.","family":"Nanagas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kovalszki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,12]]},"reference":[{"issue":"11","key":"8695_CR1","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1002\/ajh.24880","volume":"92","author":"J Gotlib","year":"2017","unstructured":"Gotlib J (2017) World Health Organization-defined eosinophilic disorders: 2017 update on diagnosis, risk stratification, and management. Am J Hematol 92(11):1243\u20131259","journal-title":"Am J Hematol"},{"issue":"4","key":"8695_CR2","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.jaci.2013.06.037","volume":"133","author":"YY Chen","year":"2014","unstructured":"Chen YY, Khoury P, Ware JM et al (2014) Marked and persistent eosinophilia in the absence of clinical manifestations. J Allergy Clin Immunol 133(4):1195\u20131202","journal-title":"J Allergy Clin Immunol"},{"key":"8695_CR3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1750-1172-2-37","volume":"2","author":"FE Roufosse","year":"2007","unstructured":"Roufosse FE, Goldman M, Cogan E (2007) Hypereosinophilic syndromes. Orphanet J Rare Dis 2:37","journal-title":"Orphanet J Rare Dis"},{"issue":"6","key":"8695_CR4","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1182\/blood-2016-10-695973","volume":"129","author":"A Reiter","year":"2017","unstructured":"Reiter A, Gotlib J (2017) Myeloid neoplasms with eosinophilia. Blood 129(6):704\u2013714","journal-title":"Blood"},{"key":"8695_CR5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1146\/annurev.med.60.062107.090340","volume":"60","author":"A Klion","year":"2009","unstructured":"Klion A (2009) Hypereosinophilic syndrome: current approach to diagnosis and treatment. Annu Rev Med 60:293\u2013306","journal-title":"Annu Rev Med"},{"key":"8695_CR6","unstructured":"Roufosse F, Klion AD, Weller PF (2017) Hypereosinophilic syndromes: clinical manifestations, pathophysiology, and diagnosis. In: Bochner BS (ed) UpToDate. UpToDate Inc., Waltham. http:\/\/www.uptodate.com . Accessed 17 December 2017"},{"issue":"1","key":"8695_CR7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jaci.2003.10.047","volume":"113","author":"ME Rothenberg","year":"2004","unstructured":"Rothenberg ME (2004) Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol 113(1):11\u201328 quiz 29","journal-title":"J Allergy Clin Immunol"},{"key":"8695_CR8","volume-title":"Middleton's allergy: principles and practice","author":"A Klion","year":"2014","unstructured":"Klion A, Weller P (2014) Eosinophilia and eosinophil-related disorders. In: Adkinson NB Jr, Burks A, Busse W, Holgate S, Lemanske R, O\u2019Hehir R (eds) Middleton's allergy: principles and practice, vol 2, 8th edn. Saunders, Welwyn Garden City. 1205. Print","edition":"8"},{"key":"8695_CR9","unstructured":"Weller P, Klion A (2017) Eosinophil biology and causes of eosinophilia. In: Mahoney DH and Bochner BS (eds). UpToDate. UpToDate Inc., Waltham. http:\/\/www.uptodate.com . Accessed 17 December 2017"},{"key":"8695_CR10","doi-asserted-by":"crossref","first-page":"463689","DOI":"10.5402\/2012\/463689","volume":"2012","author":"M Jawairia","year":"2012","unstructured":"Jawairia M, Shahzad G, Mustacchia P (2012) Eosinophilic gastrointestinal diseases: review and update. ISRN Gastroenterol 2012:463689","journal-title":"ISRN Gastroenterol"},{"issue":"12","key":"8695_CR11","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1172\/JCI6560","volume":"103","author":"A Mishra","year":"1999","unstructured":"Mishra A, Hogan SP, Lee JJ, Foster PS, Rothenberg ME (1999) Fundamental signals that regulate eosinophil homing to the gastrointestinal tract. J Clin Invest 103(12):1719\u20131727","journal-title":"J Clin Invest"},{"key":"8695_CR12","first-page":"437","volume-title":"Cellular and molecular immunology","author":"AL Abbas","year":"2018","unstructured":"Abbas AL, Lichtman AH, Pillai S (2018) Allergy. In: Cellular and molecular immunology, 9th edn. Elsevier, Philadelphia, p 437","edition":"9"},{"issue":"1","key":"8695_CR13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1398-9995.2003.00382.x","volume":"59","author":"A Straumann","year":"2004","unstructured":"Straumann A, Simon HU (2004) The physiological and pathophysiological roles of eosinophils in the gastrointestinal tract. Allergy 59(1):15\u201325","journal-title":"Allergy"},{"issue":"12","key":"8695_CR14","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/nri.2017.95","volume":"17","author":"PF Weller","year":"2017","unstructured":"Weller PF, Spencer LA (2017) Functions of tissue-resident eosinophils. Nat Rev Immunol 17(12):746\u2013760","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"8695_CR15","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.iac.2007.07.004","volume":"27","author":"SJ Ackerman","year":"2007","unstructured":"Ackerman SJ, Bochner BS (2007) Mechanisms of eosinophilia in the pathogenesis of hypereosinophilic disorders. Immunol Allergy Clin N Am 27(3):357\u2013375","journal-title":"Immunol Allergy Clin N Am"},{"issue":"5","key":"8695_CR16","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1136\/gut.2008.165894","volume":"58","author":"BM Yan","year":"2009","unstructured":"Yan BM, Shaffer EA (2009) Primary eosinophilic disorders of the gastrointestinal tract. Gut 58(5):721\u2013732","journal-title":"Gut"},{"key":"8695_CR17","unstructured":"Bonis P, Furuta G (2017) Clinical manifestations and diagnosis of eosinophilic esophagitis. In: Talley NJ (ed) UpToDate. UpToDate Inc., Waltham. http:\/\/www.uptodate.com . Accessed 17 December 2017"},{"issue":"1","key":"8695_CR18","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/gut.31.1.54","volume":"31","author":"NJ Talley","year":"1990","unstructured":"Talley NJ, Shorter RG, Phillips SF, Zinsmeister AR (1990) Eosinophilic gastroenteritis: a clinicopathological study of patients with disease of the mucosa, muscle layer, and subserosal tissues. Gut 31(1):54\u201358","journal-title":"Gut"},{"key":"8695_CR19","volume-title":"Middleton's allergy: principles and practice","author":"M Rothenberg","year":"2014","unstructured":"Rothenberg M (2014) Eosinophilic gastrointestinal disorders. In: Adkinson N Jr, Bochner B (eds) Middleton's allergy: principles and practice, vol 2, 8th edn. Saunders, Welwyn Garden City. 1095. Print","edition":"8"},{"issue":"Suppl","key":"8695_CR20","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1097\/00005176-200001001-00009","volume":"30","author":"AM Lake","year":"2000","unstructured":"Lake AM (2000) Food-induced eosinophilic proctocolitis. J Pediatr Gastroenterol Nutr 30(Suppl):S58\u2013S60","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"5","key":"8695_CR21","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/1756283X10392443","volume":"4","author":"AA Alfadda","year":"2011","unstructured":"Alfadda AA, Storr MA, Shaffer EA (2011) Eosinophilic colitis: epidemiology, clinical features, and current management. Therap Adv Gastroenterol 4(5):301\u2013309","journal-title":"Therap Adv Gastroenterol"},{"issue":"11","key":"8695_CR22","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1007\/s10620-011-1754-3","volume":"56","author":"J Lee","year":"2011","unstructured":"Lee J, Dierkhising R, Wu TT, Alexander J, Weiler C (2011) Eosinophilic gastrointestinal disorders (EGID) with peripheral eosinophilia: a retrospective review at Mayo Clinic. Dig Dis Sci 56(11):3254\u20133261","journal-title":"Dig Dis Sci"},{"issue":"6","key":"8695_CR23","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.jaci.2009.09.022","volume":"124","author":"PU Ogbogu","year":"2009","unstructured":"Ogbogu PU, Bochner BS (2009) Butterfield JH, et al. Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy. J Allergy Clin Immunol 124(6):1319\u20131325.e1313","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"8695_CR24","doi-asserted-by":"crossref","first-page":"444","DOI":"10.5946\/ce.2012.45.4.444","volume":"45","author":"YW Jeon","year":"2012","unstructured":"Jeon YW, Hong SJ, Kim HJ, Han JP, Kim HK, Ko BM, Park SK, Lee MS (2012) A hypereosinophilic syndrome presenting as eosinophilic colitis. Clin Endosc 45(4):444\u2013447","journal-title":"Clin Endosc"},{"issue":"48","key":"8695_CR25","doi-asserted-by":"crossref","first-page":"6129","DOI":"10.3748\/wjg.15.6129","volume":"15","author":"TY Park","year":"2009","unstructured":"Park TY, Choi CH, Yang SY, Oh IS, Song ID, Lee HW, Kim HJ, Do JH, Chang SK, Cho AR, Cha YJ (2009) A case of hypereosinophilic syndrome presenting with intractable gastric ulcers. World J Gastroenterol 15(48):6129\u20136133","journal-title":"World J Gastroenterol"},{"issue":"9","key":"8695_CR26","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1056\/NEJMcpc1302331","volume":"370","author":"AT Fathi","year":"2014","unstructured":"Fathi AT, Dec GW, Richter JM et al (2014) Case records of the Massachusetts General Hospital. Case 7-2014\u2014a 27-year-old man with diarrhea, fatigue, and eosinophilia. N Engl J Med 370(9):861\u2013872","journal-title":"N Engl J Med"},{"issue":"10","key":"8695_CR27","doi-asserted-by":"crossref","first-page":"675","DOI":"10.2169\/internalmedicine.46.6309","volume":"46","author":"M Kobayashi","year":"2007","unstructured":"Kobayashi M, Komatsu N, Kuwayama Y, Bandobashi K, Kubota T, Uemura Y, Taguchi H (2007) Idiopathic hypereosinophilic syndrome presenting acute abdomen. Intern Med 46(10):675\u2013678","journal-title":"Intern Med"},{"issue":"44","key":"8695_CR28","first-page":"1976","volume":"124","author":"S Bauer","year":"1994","unstructured":"Bauer S, Schaub N, Kummer H, Wegmann W (1994) Prolonged course of an idiopathic hypereosinophilic syndrome with transition to eosinophilic gastroenteritis. Schweiz Med Wochenschr 124(44):1976\u20131981","journal-title":"Schweiz Med Wochenschr"},{"issue":"1","key":"8695_CR29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/00004836-199201000-00015","volume":"14","author":"M Scheurlen","year":"1992","unstructured":"Scheurlen M, M\u00f6rk H, Weber P (1992) Hypereosinophilic syndrome resembling chronic inflammatory bowel disease with primary sclerosing cholangitis. J Clin Gastroenterol 14(1):59\u201363","journal-title":"J Clin Gastroenterol"},{"issue":"9","key":"8695_CR30","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1007\/s00595-004-2817-2","volume":"34","author":"S Murakami","year":"2004","unstructured":"Murakami S, Misumi M, Sakata H, Hirayama R, Kubojima Y, Nomura K, Ban S (2004) Churg-Strauss syndrome manifesting as perforation of the small intestine: report of a case. Surg Today 34(9):788\u2013792","journal-title":"Surg Today"},{"issue":"3","key":"8695_CR31","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/00004836-199610000-00017","volume":"23","author":"MC Sharma","year":"1996","unstructured":"Sharma MC, Safaya R, Sidhu BS (1996) Perforation of small intestine caused by Churg-Strauss syndrome. J Clin Gastroenterol 23(3):232\u2013235","journal-title":"J Clin Gastroenterol"},{"issue":"12","key":"8695_CR32","first-page":"2074","volume":"109","author":"Y Ichikawa","year":"2012","unstructured":"Ichikawa Y, Takeuchi M, Yamada M, Hosoi T, Mabuchi T, Okada A, Tomida H, Suhara H, Koya T, Suzuki H, Okada Y (2012) A case of ischemic colitis induced by hypereosinophilic syndrome. Nihon Shokakibyo Gakkai Zasshi 109(12):2074\u20132081","journal-title":"Nihon Shokakibyo Gakkai Zasshi"},{"issue":"4","key":"8695_CR33","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s12328-016-0661-8","volume":"9","author":"AC Cheung","year":"2016","unstructured":"Cheung AC, Hachem CY, Lai J (2016) Idiopathic hypereosinophilic syndrome presenting with hepatitis and achalasia. Clin J Gastroenterol 9(4):238\u2013242","journal-title":"Clin J Gastroenterol"},{"issue":"2","key":"8695_CR34","first-page":"123","volume":"11","author":"K Shatery","year":"2011","unstructured":"Shatery K, Sayyah A (2011) Idiopathic hypereosinophilic syndrome presenting with liver mass: report of two cases: idiopathic hypereosinophilic syndrome and liver mass. Hepat Mon 11(2):123\u2013125","journal-title":"Hepat Mon"},{"issue":"4","key":"8695_CR35","doi-asserted-by":"crossref","first-page":"336","DOI":"10.2169\/internalmedicine.43.336","volume":"43","author":"M Watanabe","year":"2004","unstructured":"Watanabe M, Matsui N, Hamada S et al (2004) A rare case of idiopathic hypereosinophilic syndrome involving the oral cavity associated with the esophagus and gastrointestinal tract. Intern Med 43(4):336\u2013339","journal-title":"Intern Med"},{"issue":"3","key":"8695_CR36","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/ajg.2015.438","volume":"111","author":"A Muir","year":"2016","unstructured":"Muir A, Surrey L, Kriegermeier A, Shaikhkalil A, Piccoli DA (2016) Severe eosinophilic gastroenteritis in a Crohn's disease patient treated with infliximab and adalimumab. Am J Gastroenterol 111(3):437\u2013438","journal-title":"Am J Gastroenterol"},{"issue":"12","key":"8695_CR37","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1038\/ajg.2017.402","volume":"112","author":"B Click","year":"2017","unstructured":"Click B, Anderson AM, Koutroubakis IE, Rivers CR, Babichenko D, Machicado JD, Hartman DJ, Hashash JG, Dunn MA, Schwartz M, Swoger J, Barrie III A, Wenzel SE, Regueiro M, Binion DG (2017) Peripheral eosinophilia in patients with inflammatory bowel disease defines an aggressive disease phenotype. Am J Gastroenterol 112(12):1849\u20131858","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"8695_CR38","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.iac.2007.06.002","volume":"27","author":"L Zuo","year":"2007","unstructured":"Zuo L, Rothenberg ME (2007) Gastrointestinal eosinophilia. Immunol Allergy Clin N Am 27(3):443\u2013455","journal-title":"Immunol Allergy Clin N Am"},{"issue":"44","key":"8695_CR39","doi-asserted-by":"crossref","first-page":"12709","DOI":"10.3748\/wjg.v21.i44.12709","volume":"21","author":"KM Riggle","year":"2015","unstructured":"Riggle KM, Wahbeh G, Williams EM, Riehle KJ (2015) Perforated duodenal ulcer: an unusual manifestation of allergic eosinophilic gastroenteritis. World J Gastroenterol 21(44):12709\u201312712","journal-title":"World J Gastroenterol"},{"issue":"3","key":"8695_CR40","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.iac.2015.04.001","volume":"35","author":"C Curtis","year":"2015","unstructured":"Curtis C, Ogbogu PU (2015) Evaluation and differential diagnosis of persistent marked eosinophilia. Immunol Allergy Clin N Am 35(3):387\u2013402","journal-title":"Immunol Allergy Clin N Am"},{"issue":"1","key":"8695_CR41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jaci.2010.03.035","volume":"126","author":"MM Crane","year":"2010","unstructured":"Crane MM, Chang CM, Kobayashi MG, Weller PF (2010) Incidence of myeloproliferative hypereosinophilic syndrome in the United States and an estimate of all hypereosinophilic syndrome incidence. J Allergy Clin Immunol 126(1):179\u2013181","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"8695_CR42","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.leukres.2012.12.016","volume":"37","author":"JC Podjasek","year":"2013","unstructured":"Podjasek JC, Butterfield JH (2013) Mortality in hypereosinophilic syndrome: 19\u00a0years of experience at Mayo Clinic with a review of the literature. Leuk Res 37(4):392\u2013395","journal-title":"Leuk Res"},{"issue":"4","key":"8695_CR43","first-page":"253","volume":"140","author":"C Lefebvre","year":"1989","unstructured":"Lefebvre C, Bletry O, Degoulet P, Guillevin L, Bentata-Pessayre M, le Thi Huong du, Godeau P (1989) Prognostic factors of hypereosinophilic syndrome. Study of 40 cases. Ann Med Interne (Paris) 140(4):253\u2013257","journal-title":"Ann Med Interne (Paris)"},{"issue":"7","key":"8695_CR44","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/MPH.0000000000000668","volume":"38","author":"B Tavil","year":"2016","unstructured":"Tavil B, Ayta\u00e7 S, Unal S, Kuskonmaz B, Gumruk F, Cetin M (2016) Hypereosinophilic syndrome: Hacettepe experience. J Pediatr Hematol Oncol 38(7):539\u2013543","journal-title":"J Pediatr Hematol Oncol"},{"issue":"5","key":"8695_CR45","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.leukres.2006.10.005","volume":"31","author":"C Vaklavas","year":"2007","unstructured":"Vaklavas C, Tefferi A, Butterfield J, Ketterling R, Verstovsek S, Kantarjian H, Pardanani A (2007) Idiopathic' eosinophilia with an occult T-cell clone: prevalence and clinical course. Leuk Res 31(5):691\u2013694","journal-title":"Leuk Res"},{"issue":"12","key":"8695_CR46","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1182\/blood-2003-01-0006","volume":"101","author":"AD Klion","year":"2003","unstructured":"Klion AD, Noel P, Akin C, Law MA, Gilliland DG, Cools J, Metcalfe DD, Nutman TB (2003) Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness. Blood 101(12):4660\u20134666","journal-title":"Blood"},{"issue":"3","key":"8695_CR47","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.iac.2015.05.006","volume":"35","author":"F Roufosse","year":"2015","unstructured":"Roufosse F (2015) Management of hypereosinophilic syndromes. Immunol Allergy Clin N Am 35(3):561\u2013575","journal-title":"Immunol Allergy Clin N Am"},{"issue":"1","key":"8695_CR48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005792-197501000-00001","volume":"54","author":"MJ Chusid","year":"1975","unstructured":"Chusid MJ, Dale DC, West BC, Wolff SM (1975) The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine (Baltimore) 54(1):1\u201327","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"8695_CR49","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.pop.2016.07.010","volume":"43","author":"A Kovalszki","year":"2016","unstructured":"Kovalszki A, Weller PF (2016) Eosinophilia. Prim Care 43(4):607\u2013617","journal-title":"Prim Care"},{"issue":"2","key":"8695_CR50","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.iac.2014.01.013","volume":"34","author":"A Kovalszki","year":"2014","unstructured":"Kovalszki A, Weller PF (2014) Eosinophilia in mast cell disease. Immunol Allergy Clin N Am 34(2):357\u2013364","journal-title":"Immunol Allergy Clin N Am"},{"key":"8695_CR51","doi-asserted-by":"crossref","first-page":"603","DOI":"10.12659\/AJCR.894110","volume":"16","author":"V Pochineni","year":"2015","unstructured":"Pochineni V, Lal D, Hasnayen S, Restrepo E (2015) Fatal strongyloides hyperinfection syndrome in an immunocompromised patient. Am J Case Rep 16:603\u2013605","journal-title":"Am J Case Rep"},{"issue":"6","key":"8695_CR52","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1034\/j.1398-9995.1999.00140.x","volume":"54","author":"O Villarreal","year":"1999","unstructured":"Villarreal O, Villarreal JJ, Domingo JA (1999) Progressive eosinophilia and elevated IgE in enterobiasis. Allergy 54(6):646\u2013648","journal-title":"Allergy"},{"issue":"5","key":"8695_CR53","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1016\/j.anai.2017.08.193","volume":"119","author":"V Nanagas","year":"2017","unstructured":"Nanagas V, Montejo J (2017) Hypereosinophilia with systemic symptoms due to pinworm. Ann Allergy Asthma Immunol 119(5):S70","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"8","key":"8695_CR54","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.clinbiochem.2003.08.004","volume":"36","author":"AA Ermens","year":"2003","unstructured":"Ermens AA, Vlasveld LT, Lindemans J (2003) Significance of elevated cobalamin (vitamin B12) levels in blood. Clin Biochem 36(8):585\u2013590","journal-title":"Clin Biochem"},{"issue":"4","key":"8695_CR55","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1182\/blood.V63.4.779.779","volume":"63","author":"J Zittoun","year":"1984","unstructured":"Zittoun J, Farcet JP, Marquet J, Sultan C, Zittoun R (1984) Cobalamin (vitamin B12) and B12 binding proteins in hypereosinophilic syndromes and secondary eosinophilia. Blood 63(4):779\u2013783","journal-title":"Blood"},{"issue":"1","key":"8695_CR56","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.rmed.2010.09.011","volume":"105","author":"MM Dulohery","year":"2011","unstructured":"Dulohery MM, Patel RR, Schneider F, Ryu JH (2011) Lung involvement in hypereosinophilic syndromes. Respir Med 105(1):114\u2013121","journal-title":"Respir Med"},{"issue":"2","key":"8695_CR57","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1148\/rg.2016150145","volume":"36","author":"RS Katre","year":"2016","unstructured":"Katre RS, Sunnapwar A, Restrepo CS, Katabathina VS, Mumbower A, Baxi A, Sonavane S (2016) Cardiopulmonary and gastrointestinal manifestations of eosinophil- associated diseases and idiopathic hypereosinophilic syndromes: multimodality imaging approach. Radiographics 36(2):433\u2013451","journal-title":"Radiographics"},{"issue":"8","key":"8695_CR58","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/ajg.2014.166","volume":"109","author":"HM Ko","year":"2014","unstructured":"Ko HM, Morotti RA, Yershov O, Chehade M (2014) Eosinophilic gastritis in children: clinicopathological correlation, disease course, and response to therapy. Am J Gastroenterol 109(8):1277\u20131285","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"8695_CR59","first-page":"110","volume":"9","author":"A Lowichik","year":"1996","unstructured":"Lowichik A, Weinberg AG (1996) A quantitative evaluation of mucosal eosinophils in the pediatric gastrointestinal tract. Mod Pathol 9(2):110\u2013114","journal-title":"Mod Pathol"},{"issue":"3","key":"8695_CR60","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2350\/11-05-0130.1","volume":"9","author":"CW DeBrosse","year":"2006","unstructured":"DeBrosse CW, Case JW, Putnam PE, Collins MH, Rothenberg ME (2006) Quantity and distribution of eosinophils in the gastrointestinal tract of children. Pediatr Dev Pathol 9(3):210\u2013218","journal-title":"Pediatr Dev Pathol"},{"issue":"4","key":"8695_CR61","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/modpathol.2010.221","volume":"24","author":"T Lwin","year":"2011","unstructured":"Lwin T, Melton SD, Genta RM (2011) Eosinophilic gastritis: histopathological characterization and quantification of the normal gastric eosinophil content. Mod Pathol 24(4):556\u2013563","journal-title":"Mod Pathol"},{"issue":"4","key":"8695_CR62","first-page":"363","volume":"10","author":"RR Pascal","year":"1997","unstructured":"Pascal RR, Gramlich TL, Parker KM, Gansler TS (1997) Geographic variations in eosinophil concentration in normal colonic mucosa. Mod Pathol 10(4):363\u2013365","journal-title":"Mod Pathol"},{"issue":"6","key":"8695_CR63","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.humpath.2007.10.012","volume":"39","author":"AD Polydorides","year":"2008","unstructured":"Polydorides AD, Banner BF, Hannaway PJ, Yantiss RK (2008) Evaluation of site-specific and seasonal variation in colonic mucosal eosinophils. Hum Pathol 39(6):832\u2013836","journal-title":"Hum Pathol"},{"issue":"18","key":"8695_CR64","doi-asserted-by":"crossref","first-page":"3736","DOI":"10.1182\/blood-2009-07-143552","volume":"114","author":"AD Klion","year":"2009","unstructured":"Klion AD (2009) How I treat hypereosinophilic syndromes. Blood 114(18):3736\u20133741","journal-title":"Blood"},{"issue":"11","key":"8695_CR65","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1182\/blood-2003-11-3850","volume":"103","author":"AD Klion","year":"2004","unstructured":"Klion AD, Law MA, Riemenschneider W, McMaster M, Brown MR, Horne M, Karp B, Robinson M, Sachdev V, Tucker E, Turner M, Nutman TB (2004) Familial eosinophilia: a benign disorder? Blood 103(11):4050\u20134055","journal-title":"Blood"},{"issue":"1","key":"8695_CR66","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1172\/JCI110024","volume":"67","author":"LC Altman","year":"1981","unstructured":"Altman LC, Hill JS, Hairfield WM, Mullarkey MF (1981) Effects of corticosteroids on eosinophil chemotaxis and adherence. J Clin Invest 67(1):28\u201336","journal-title":"J Clin Invest"},{"key":"8695_CR67","doi-asserted-by":"crossref","unstructured":"Roufosse F, Klion A, Weller P. Hypereosinophilic syndromes: treatment. In: UpToDate, Bochner BS (eds) UpToDate. UpToDate Inc., Waltham. http:\/\/www.uptodate.com . Accessed 17 December 2017","DOI":"10.1097\/01.COT.0000512180.05121.bb"},{"key":"8695_CR68","doi-asserted-by":"crossref","unstructured":"Khoury P, Abiodun AO, Holland-Thomas N, Fay MP, Klion AD (2017) Hypereosinophilic syndrome subtype predicts responsiveness to glucocorticoids. J Allergy Clin Immunol Pract","DOI":"10.1016\/j.jaip.2017.06.006"},{"issue":"6","key":"8695_CR69","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1155\/2015\/531675","volume":"26","author":"E Vaisben","year":"2015","unstructured":"Vaisben E, Brand R, Kadakh A, Nassar F (2015) The role of empirical albendazole treatment in idiopathic hypereosinophilia\u2014a case series. Can J Infect Dis Med Microbiol 26(6):323\u2013324","journal-title":"Can J Infect Dis Med Microbiol"},{"issue":"6","key":"8695_CR70","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.jaci.2006.02.042","volume":"117","author":"AD Klion","year":"2006","unstructured":"Klion AD, Bochner BS, Gleich GJ et al (2006) Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report. J Allergy Clin Immunol 117(6):1292\u20131302","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"8695_CR71","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/all.12843","volume":"71","author":"P Khoury","year":"2016","unstructured":"Khoury P, Desmond R, Pabon A, Holland-Thomas N, Ware JM, Arthur DC, Kurlander R, Fay MP, Maric I, Klion AD (2016) Clinical features predict responsiveness to imatinib in platelet-derived growth factor receptor-alpha-negative hypereosinophilic syndrome. Allergy 71(6):803\u2013810","journal-title":"Allergy"},{"issue":"4","key":"8695_CR72","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.jaci.2010.06.049","volume":"126","author":"F Roufosse","year":"2010","unstructured":"Roufosse F, de Lavareille A, Schanden\u00e9 L, Cogan E, Georgelas A, Wagner L, Xi L, Raffeld M, Goldman M, Gleich GJ, Klion A (2010) Mepolizumab as a corticosteroid-sparing agent in lymphocytic variant hypereosinophilic syndrome. J Allergy Clin Immunol 126(4):828\u2013835.e823","journal-title":"J Allergy Clin Immunol"},{"issue":"12","key":"8695_CR73","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1056\/NEJMoa070812","volume":"358","author":"ME Rothenberg","year":"2008","unstructured":"Rothenberg ME, Klion AD, Roufosse FE et al (2008) Treatment of patients with the hypereosinophilic syndrome with mepolizumab. N Engl J Med 358(12):1215\u20131228","journal-title":"N Engl J Med"},{"issue":"6","key":"8695_CR74","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.jaip.2017.08.001","volume":"5","author":"FL Kuang","year":"2017","unstructured":"Kuang FL, Klion AD (2017) Biologic agents for the treatment of hypereosinophilic syndromes. J Allergy Clin Immunol Pract 5(6):1502\u20131509","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"2","key":"8695_CR75","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jaci.2011.11.044","volume":"129","author":"JM Spergel","year":"2012","unstructured":"Spergel JM, Rothenberg ME, Collins MH, Furuta GT, Markowitz JE, Fuchs G III, O\u2019Gorman MA, Abonia JP, Young J, Henkel T, Wilkins HJ, Liacouras CA (2012) Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol 129(2):456\u2013463 463.e451-453","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"8695_CR76","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1053\/j.gastro.2011.07.044","volume":"141","author":"AH Assa'ad","year":"2011","unstructured":"Assa'ad AH, Gupta SK, Collins MH, Thomson M, Heath AT, Smith DA, Perschy TL, Jurgensen CH, Ortega HG, Aceves SS (2011) An antibody against IL-5 reduces numbers of esophageal intraepithelial eosinophils in children with eosinophilic esophagitis. Gastroenterology 141(5):1593\u20131604","journal-title":"Gastroenterology"},{"issue":"9","key":"8695_CR77","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1136\/gut.29.9.1282","volume":"29","author":"RJ Moots","year":"1988","unstructured":"Moots RJ, Prouse P, Gumpel JM (1988) Near fatal eosinophilic gastroenteritis responding to oral sodium chromoglycate. Gut 29(9):1282\u20131285","journal-title":"Gut"},{"issue":"3","key":"8695_CR78","first-page":"193","volume":"21","author":"J Suzuki","year":"2003","unstructured":"Suzuki J, Kawasaki Y, Nozawa R, Isome M, Suzuki S, Takahashi A, Suzuki H (2003) Oral disodium cromoglycate and ketotifen for a patient with eosinophilic gastroenteritis, food allergy and protein-losing enteropathy. Asian Pac J Allergy Immunol 21(3):193\u2013197","journal-title":"Asian Pac J Allergy Immunol"},{"issue":"5","key":"8695_CR79","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0025-6196(12)61640-1","volume":"69","author":"RG Dellen Van","year":"1994","unstructured":"Van Dellen RG, Lewis JC (1994) Oral administration of cromolyn in a patient with protein-losing enteropathy, food allergy, and eosinophilic gastroenteritis. Mayo Clin Proc 69(5):441\u2013444","journal-title":"Mayo Clin Proc"},{"issue":"12","key":"8695_CR80","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S1542-3565(05)00885-2","volume":"3","author":"CA Liacouras","year":"2005","unstructured":"Liacouras CA, Spergel JM, Ruchelli E, Verma R, Mascarenhas M, Semeao E, Flick J, Kelly J, Brown\u2013Whitehorn T, Mamula P, Markowitz JE (2005) Eosinophilic esophagitis: a 10-year experience in 381 children. Clin Gastroenterol Hepatol 3(12):1198\u20131206","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"9","key":"8695_CR81","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1080\/17512433.2016.1190268","volume":"9","author":"S Hua","year":"2016","unstructured":"Hua S, Cook D, Walker MM, Talley NJ (2016) Pharmacological treatment of eosinophilic gastrointestinal disorders. Expert Rev Clin Pharmacol 9(9):1195\u20131209","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"3","key":"8695_CR82","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2217\/imt.14.3","volume":"6","author":"A Cianferoni","year":"2014","unstructured":"Cianferoni A, Spergel JM (2014) Immunotherapeutic approaches for the treatment of eosinophilic esophagitis. Immunotherapy 6(3):321\u2013331","journal-title":"Immunotherapy"},{"issue":"8","key":"8695_CR83","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1080\/1744666X.2016.1191947","volume":"12","author":"T Imam","year":"2016","unstructured":"Imam T, Gupta SK (2016) Topical glucocorticoid vs. diet therapy in eosinophilic esophagitis: the need for better treatment options. Expert Rev Clin Immunol 12(8):797\u2013799","journal-title":"Expert Rev Clin Immunol"},{"issue":"4","key":"8695_CR84","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jaip.2013.05.009","volume":"1","author":"M Greenhawt","year":"2013","unstructured":"Greenhawt M, Aceves SS, Spergel JM, Rothenberg ME (2013) The management of eosinophilic esophagitis. J Allergy Clin Immunol Pract 1(4):332\u2013340 quiz 341-332","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"7","key":"8695_CR85","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1053\/j.gastro.2014.02.006","volume":"146","author":"A Arias","year":"2014","unstructured":"Arias A, Gonz\u00e1lez-Cervera J, Tenias JM, Lucendo AJ (2014) Efficacy of dietary interventions for inducing histologic remission in patients with eosinophilic esophagitis: a systematic review and meta-analysis. Gastroenterology 146(7):1639\u20131648","journal-title":"Gastroenterology"},{"issue":"12","key":"8695_CR86","first-page":"772","volume":"6","author":"DB Ramsay","year":"2010","unstructured":"Ramsay DB, Stephen S, Borum M, Voltaggio L, Doman DB (2010) Mast cells in gastrointestinal disease. Gastroenterol Hepatol (N Y) 6(12):772\u2013777","journal-title":"Gastroenterol Hepatol (N Y)"},{"issue":"6","key":"8695_CR87","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1097\/PAS.0000000000000190","volume":"38","author":"LA Doyle","year":"2014","unstructured":"Doyle LA, Sepehr GJ, Hamilton MJ, Akin C, Castells MC, Hornick JL (2014) A clinicopathologic study of 24 cases of systemic mastocytosis involving the gastrointestinal tract and assessment of mucosal mast cell density in irritable bowel syndrome and asymptomatic patients. Am J Surg Pathol 38(6):832\u2013843","journal-title":"Am J Surg Pathol"},{"key":"8695_CR88","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/978-1-4419-9533-9_1","volume":"716","author":"AM Gilfillan","year":"2011","unstructured":"Gilfillan AM, Austin SJ, Metcalfe DD (2011) Mast cell biology: introduction and overview. Adv Exp Med Biol 716:2\u201312","journal-title":"Adv Exp Med Biol"},{"key":"8695_CR89","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/B978-0-323-08593-9.00015-2","volume-title":"Middleton 's allergy: principles and practice","author":"P Bradding","year":"2014","unstructured":"Bradding P, Saito H (2014) Biology of mast cells and their mediators. In: Adkinson N Jr, Bochner B (eds) Middleton 's allergy: principles and practice, vol 1, 8th edn. Saunders, Welwyn Garden City, pp 228\u2013251","edition":"8"},{"issue":"2","key":"8695_CR90","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.4049\/jimmunol.172.2.1139","volume":"172","author":"MF Gurish","year":"2004","unstructured":"Gurish MF, Bryce PJ, Tao H, Kisselgof AB, Thornton EM, Miller HR, Friend DS, Oettgen HC (2004) IgE enhances parasite clearance and regulates mast cell responses in mice infected with Trichinella spiralis. J Immunol 172(2):1139\u20131145","journal-title":"J Immunol"},{"issue":"7","key":"8695_CR91","doi-asserted-by":"crossref","first-page":"4885","DOI":"10.4049\/jimmunol.180.7.4885","volume":"180","author":"K Shin","year":"2008","unstructured":"Shin K, Watts GF, Oettgen HC et al (2008) Mouse mast cell tryptase mMCP-6 is a critical link between adaptive and innate immunity in the chronic phase of Trichinella spiralis infection. J Immunol 180(7):4885\u20134891","journal-title":"J Immunol"},{"issue":"11","key":"8695_CR92","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.4049\/jimmunol.160.11.5537","volume":"160","author":"DS Friend","year":"1998","unstructured":"Friend DS, Ghildyal N, Gurish MF et al (1998) Reversible expression of tryptases and chymases in the jejunal mast cells of mice infected with Trichinella spiralis. J Immunol 160(11):5537\u20135545","journal-title":"J Immunol"},{"key":"8695_CR93","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejphar.2015.07.017","volume":"778","author":"Y Yu","year":"2016","unstructured":"Yu Y, Blokhuis BR, Garssen J, Redegeld FA (2016) Non-IgE mediated mast cell activation. Eur J Pharmacol 778:33\u201343","journal-title":"Eur J Pharmacol"},{"issue":"12","key":"8695_CR94","doi-asserted-by":"crossref","first-page":"29069","DOI":"10.3390\/ijms161226151","volume":"16","author":"A Aich","year":"2015","unstructured":"Aich A, Afrin LB, Gupta K (2015) Mast cell-mediated mechanisms of nociception. Int J Mol Sci 16(12):29069\u201329092","journal-title":"Int J Mol Sci"},{"issue":"4","key":"8695_CR95","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/ACI.0000000000000377","volume":"17","author":"T G\u00fclen","year":"2017","unstructured":"G\u00fclen T, Akin C (2017) Pharmacotherapy of mast cell disorders. Curr Opin Allergy Clin Immunol 17(4):295\u2013303","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"6","key":"8695_CR96","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.jaci.2010.08.035","volume":"126","author":"C Akin","year":"2010","unstructured":"Akin C, Valent P, Metcalfe DD (2010) Mast cell activation syndrome: proposed diagnostic criteria. J Allergy Clin Immunol 126(6):1099\u20131104.e1094","journal-title":"J Allergy Clin Immunol"},{"key":"8695_CR97","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev-pathol-052016-100312","volume":"12","author":"DD Metcalfe","year":"2017","unstructured":"Metcalfe DD, Mekori YA (2017) Pathogenesis and pathology of mastocytosis. Annu Rev Pathol 12:487\u2013514","journal-title":"Annu Rev Pathol"},{"issue":"1","key":"8695_CR98","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jaip.2013.09.004","volume":"2","author":"S Jennings","year":"2014","unstructured":"Jennings S, Russell N, Jennings B, Slee V, Sterling L, Castells M, Valent P, Akin C (2014) The Mastocytosis Society survey on mast cell disorders: patient experiences and perceptions. J Allergy Clin Immunol Pract 2(1):70\u201376","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"3","key":"8695_CR99","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0889-8588(05)70298-7","volume":"14","author":"RT Jensen","year":"2000","unstructured":"Jensen RT (2000) Gastrointestinal abnormalities and involvement in systemic mastocytosis. Hematol Oncol Clin North Am 14(3):579\u2013623","journal-title":"Hematol Oncol Clin North Am"},{"issue":"4","key":"8695_CR100","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.jaci.2013.05.026","volume":"132","author":"H Sokol","year":"2013","unstructured":"Sokol H, Georgin-Lavialle S, Canioni D, Barete S, Damaj G, Soucie E, Bruneau J, Chandesris MO, Suarez F, Launay JM, Aouba A, Grandpeix-Guyodo C, Lanternier F, Grosbois B, de Gennes C, Cath\u00e9bras P, Fain O, Hoyeau-Idrissi N, Dubreuil P, Lortholary O, Beaugerie L, Ranque B, Hermine O (2013) Gastrointestinal manifestations in mastocytosis: a study of 83 patients. J Allergy Clin Immunol 132(4):866\u2013873 e861\u2013863","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"8695_CR101","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0016-5085(88)80012-X","volume":"95","author":"JA Cherner","year":"1988","unstructured":"Cherner JA, Jensen RT, Dubois A, O'Dorisio TM, Gardner JD, Metcalfe DD (1988) Gastrointestinal dysfunction in systemic mastocytosis. A prospective study. Gastroenterology 95(3):657\u2013667","journal-title":"Gastroenterology"},{"issue":"9","key":"8695_CR102","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.5858\/arpa.2013-0271-CR","volume":"137","author":"A Behdad","year":"2013","unstructured":"Behdad A, Owens SR (2013) Systemic mastocytosis involving the gastrointestinal tract: case report and review. Arch Pathol Lab Med. 137(9):1220\u20131223","journal-title":"Arch Pathol Lab Med."},{"issue":"1","key":"8695_CR103","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1159\/000350678","volume":"6","author":"S A Akbar","year":"2013","unstructured":"A Akbar S, Raza S, E Denney J, J Johannesen E, C Doll D (2013) Systemic mastocytosis presenting as acute appendicitis: a case report and review of the literature. Case Rep Oncol 6(1):174\u2013179","journal-title":"Case Rep Oncol"},{"issue":"2","key":"8695_CR104","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jaci.2017.06.007","volume":"140","author":"C Akin","year":"2017","unstructured":"Akin C (2017) Mast cell activation syndromes. J Allergy Clin Immunol 140(2):349\u2013355","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"8695_CR105","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1136\/gut.2006.100594","volume":"56","author":"M Guilarte","year":"2007","unstructured":"Guilarte M, Santos J, de Torres I, Alonso C, Vicario M, Ramos L, Martinez C, Casellas F, Saperas E, Malagelada JR (2007) Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum. Gut 56(2):203\u2013209","journal-title":"Gut"},{"issue":"3","key":"8695_CR106","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1053\/j.gastro.2003.11.055","volume":"126","author":"G Barbara","year":"2004","unstructured":"Barbara G, Stanghellini V, De Giorgio R et al (2004) Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 126(3):693\u2013702","journal-title":"Gastroenterology"},{"issue":"1","key":"8695_CR107","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1136\/gutjnl-2015-309151","volume":"65","author":"MM Wouters","year":"2016","unstructured":"Wouters MM, Vicario M, Santos J (2016) The role of mast cells in functional GI disorders. Gut 65(1):155\u2013168","journal-title":"Gut"},{"issue":"8","key":"8695_CR108","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1136\/gutjnl-2013-305690","volume":"63","author":"T Vanuytsel","year":"2014","unstructured":"Vanuytsel T, van Wanrooy S, Vanheel H, Vanormelingen C, Verschueren S, Houben E, Salim Rasoel S, T\u03ccth J, Holvoet L, Farr\u00e9 R, van Oudenhove L, Boeckxstaens G, Verbeke K, Tack J (2014) Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism. Gut 63(8):1293\u20131299","journal-title":"Gut"},{"key":"8695_CR109","first-page":"2031480","volume":"2016","author":"KN Lee","year":"2016","unstructured":"Lee KN, Lee OY (2016) The role of mast cells in irritable bowel syndrome. Gastroenterol Res Pract 2016:2031480","journal-title":"Gastroenterol Res Pract"},{"issue":"7","key":"8695_CR110","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0145-2126(01)00038-8","volume":"25","author":"P Valent","year":"2001","unstructured":"Valent P, Horny HP, Escribano L, Longley BJ, Li CY, Schwartz LB, Marone G, Nu\u00f1ez R, Akin C, Sotlar K, Sperr WR, Wolff K, Brunning RD, Parwaresch RM, Austen KF, Lennert K, Metcalfe DD, Vardiman JW, Bennett JM (2001) Diagnostic criteria and classification of mastocytosis: a consensus proposal. Leuk Res 25(7):603\u2013625","journal-title":"Leuk Res"},{"issue":"3","key":"8695_CR111","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000328760","volume":"157","author":"P Valent","year":"2012","unstructured":"Valent P, Akin C, Arock M, Brockow K, Butterfield JH, Carter MC, Castells M, Escribano L, Hartmann K, Lieberman P, Nedoszytko B, Orfao A, Schwartz LB, Sotlar K, Sperr WR, Triggiani M, Valenta R, Horny HP, Metcalfe DD (2012) Definitions, criteria and global classification of mast cell disorders with special reference to mast cell activation syndromes: a consensus proposal. Int Arch Allergy Immunol 157(3):215\u2013225","journal-title":"Int Arch Allergy Immunol"},{"issue":"2","key":"8695_CR112","doi-asserted-by":"crossref","first-page":"225","DOI":"10.5858\/arpa.2013-0594-OA","volume":"139","author":"A Sethi","year":"2015","unstructured":"Sethi A, Jain D, Roland BC, Kinzel J, Gibson J, Schrader R, Hanson JA (2015) Performing colonic mast cell counts in patients with chronic diarrhea of unknown etiology has limited diagnostic use. Arch Pathol Lab Med. 139(2):225\u2013232","journal-title":"Arch Pathol Lab Med."},{"issue":"3","key":"8695_CR113","doi-asserted-by":"crossref","first-page":"362","DOI":"10.5858\/2006-130-362-MEIMMC","volume":"130","author":"S Jakate","year":"2006","unstructured":"Jakate S, Demeo M, John R, Tobin M, Keshavarzian A (2006) Mastocytic enterocolitis: increased mucosal mast cells in chronic intractable diarrhea. Arch Pathol Lab Med 130(3):362\u2013367","journal-title":"Arch Pathol Lab Med"},{"issue":"3","key":"8695_CR114","doi-asserted-by":"crossref","first-page":"280","DOI":"10.5217\/ir.2016.14.3.280","volume":"14","author":"H Seo","year":"2016","unstructured":"Seo H, Park SH, Byeon JS, Woo CG, Hong SM, Chang K, So H, Kwak M, Kim WS, Lee JM, Yang DH, Kim KJ, Ye BD, Myung SJ, Yang SK (2016) Chronic intractable diarrhea caused by gastrointestinal mastocytosis. Intest Res 14(3):280\u2013284","journal-title":"Intest Res"},{"issue":"5","key":"8695_CR115","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/0091-6749(90)90067-E","volume":"85","author":"RF Horan","year":"1990","unstructured":"Horan RF, Sheffer AL, Austen KF (1990) Cromolyn sodium in the management of systemic mastocytosis. J Allergy Clin Immunol 85(5):852\u2013855","journal-title":"J Allergy Clin Immunol"},{"issue":"3 Suppl","key":"8695_CR116","doi-asserted-by":"crossref","first-page":"55S","DOI":"10.1111\/1523-1747.ep12469049","volume":"96","author":"DD Metcalfe","year":"1991","unstructured":"Metcalfe DD (1991) The treatment of mastocytosis: an overview. J Investig Dermatol 96(3 Suppl):55S\u201356S discussion 56S-59S, 60S-65S","journal-title":"J Investig Dermatol"},{"issue":"12","key":"8695_CR117","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/apt.13167","volume":"41","author":"SS Rao","year":"2015","unstructured":"Rao SS, Yu S, Fedewa A (2015) Systematic review: dietary fibre and FODMAP-restricted diet in the management of constipation and irritable bowel syndrome. Aliment Pharmacol Ther 41(12):1256\u20131270","journal-title":"Aliment Pharmacol Ther"},{"key":"8695_CR118","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fmed.2017.00103","volume":"4","author":"MR Galdiero","year":"2017","unstructured":"Galdiero MR, Varricchi G, Seaf M, Marone G, Levi-Schaffer F (2017) Bidirectional mast cell-eosinophil interactions in inflammatory disorders and cancer. Front Med (Lausanne) 4:103","journal-title":"Front Med (Lausanne)"},{"key":"8695_CR119","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/bs.ai.2014.09.002","volume":"125","author":"N Landolina","year":"2015","unstructured":"Landolina N, Gangwar RS, Levi-Schaffer F (2015) Mast cells' integrated actions with eosinophils and fibroblasts in allergic inflammation: implications for therapy. Adv Immunol 125:41\u201385","journal-title":"Adv Immunol"},{"issue":"3","key":"8695_CR120","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00441-010-1010-8","volume":"341","author":"Y Minai-Fleminger","year":"2010","unstructured":"Minai-Fleminger Y, Elishmereni M, Vita F, Rosa Soranzo M, Mankuta D, Zabucchi G, Levi-Schaffer F (2010) Ultrastructural evidence for human mast cell-eosinophil interactions in vitro. Cell Tissue Res 341(3):405\u2013415","journal-title":"Cell Tissue Res"},{"issue":"3","key":"8695_CR121","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1398-9995.2010.02494.x","volume":"66","author":"M Elishmereni","year":"2011","unstructured":"Elishmereni M, Alenius HT, Bradding P, Mizrahi S, Shikotra A, Minai-Fleminger Y, Mankuta D, Eliashar R, Zabucchi G, Levi-Schaffer F (2011) Physical interactions between mast cells and eosinophils: a novel mechanism enhancing eosinophil survival in vitro. Allergy 66(3):376\u2013385","journal-title":"Allergy"},{"issue":"2","key":"8695_CR122","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/all.12059","volume":"68","author":"M Elishmereni","year":"2013","unstructured":"Elishmereni M, Bachelet I, Nissim Ben-Efraim AH, Mankuta D, Levi-Schaffer F (2013) Interacting mast cells and eosinophils acquire an enhanced activation state in vitro. Allergy 68(2):171\u2013179","journal-title":"Allergy"},{"issue":"12","key":"8695_CR123","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1080\/17474086.2016.1254036","volume":"9","author":"V Wilde De","year":"2016","unstructured":"De Wilde V, Roufosse F, Hermine O (2016) Clonal eosinophil and mast cell diseases: different in the same way? Expert Rev Hematol 9(12):1107\u20131109","journal-title":"Expert Rev Hematol"},{"issue":"1","key":"8695_CR124","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jaci.2010.04.009","volume":"126","author":"JP Abonia","year":"2010","unstructured":"Abonia JP, Blanchard C, Butz BB, Rainey HF, Collins MH, Stringer K, Putnam PE, Rothenberg ME (2010) Involvement of mast cells in eosinophilic esophagitis. J Allergy Clin Immunol 126(1):140\u2013149","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"8695_CR125","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/j.jaci.2013.02.042","volume":"131","author":"IM Otani","year":"2013","unstructured":"Otani IM, Anilkumar AA, Newbury RO, Bhagat M, Beppu LY, Dohil R, Broide DH, Aceves SS (2013) Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis. J Allergy Clin Immunol 131(6):1576\u20131582","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"8695_CR126","doi-asserted-by":"crossref","first-page":"e207","DOI":"10.1016\/j.jaad.2014.05.037","volume":"71","author":"R Nin-Asai","year":"2014","unstructured":"Nin-Asai R, Kono M, Akiyama M (2014) Urticaria pigmentosa complicated with esophageal eosinophilia. J Am Acad Dermatol 71(5):e207\u2013e208","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"8695_CR127","doi-asserted-by":"crossref","first-page":"230","DOI":"10.2478\/v10039-012-0029-3","volume":"57","author":"O Stasikowska-Kanicka","year":"2012","unstructured":"Stasikowska-Kanicka O, Danilewicz M, G\u0142owacka A, W\u0105growska-Danilewicz M (2012) Mast cells and eosinophils are involved in activation of ulcerative colitis. Adv Med Sci 57(2):230\u2013236","journal-title":"Adv Med Sci"}],"container-title":["Clinical Reviews in Allergy &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-018-8695-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12016-018-8695-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-018-8695-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T18:04:29Z","timestamp":1693764269000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12016-018-8695-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,12]]},"references-count":127,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["8695"],"URL":"https:\/\/doi.org\/10.1007\/s12016-018-8695-y","relation":{},"ISSN":["1080-0549","1559-0267"],"issn-type":[{"value":"1080-0549","type":"print"},{"value":"1559-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,12]]},"assertion":[{"value":"12 July 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}