{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:24:05Z","timestamp":1790051045403,"version":"4.0.1"},"reference-count":238,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the Program for Guangdong Introducing Innovative and Entrepreneurial Teams","award":["2017ZT07S054"],"award-info":[{"award-number":["2017ZT07S054"]}]},{"name":"the National Key R&D Program of China","award":["2017YFA0205600"],"award-info":[{"award-number":["2017YFA0205600"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81901653"],"award-info":[{"award-number":["81901653"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81701597"],"award-info":[{"award-number":["81701597"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clinic Rev Allerg Immunol"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s12016-020-08793-7","type":"journal-article","created":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T20:02:33Z","timestamp":1589140953000},"page":"111-131","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Immunobiology of T Cells in Sj\u00f6gren\u2019s Syndrome"],"prefix":"10.1007","volume":"60","author":[{"given":"Yuan","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Fen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai-Yue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Eric","family":"Gershwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe-Xiong","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,11]]},"reference":[{"issue":"3","key":"8793_CR1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s12016-018-8709-9","volume":"56","author":"JM Anaya","year":"2019","unstructured":"Anaya JM et al (2019) Sjogren\u2019s syndrome and autoimmune thyroid disease: two sides of the same coin. Clin Rev Allergy Immunol 56(3):362\u2013374","journal-title":"Clin Rev Allergy Immunol"},{"issue":"11","key":"8793_CR2","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1136\/annrheumdis-2014-205375","volume":"74","author":"B Qin","year":"2015","unstructured":"Qin B et al (2015) Epidemiology of primary Sjogren\u2019s syndrome: a systematic review and meta-analysis. Ann Rheum Dis 74(11):1983\u20131989","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"8793_CR3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/bjh.13192","volume":"168","author":"G Nocturne","year":"2015","unstructured":"Nocturne G, Mariette X (2015) Sjogren syndrome-associated lymphomas: an update on pathogenesis and management. Br J Haematol 168(3):317\u2013327","journal-title":"Br J Haematol"},{"key":"8793_CR4","doi-asserted-by":"crossref","first-page":"102335","DOI":"10.1016\/j.jaut.2019.102335","volume":"104","author":"S Katsiougiannis","year":"2019","unstructured":"Katsiougiannis S, Tenta R, Skopouli FN (2019) Autoimmune epithelitis (Sjogren\u2019 syndrome); the impact of metabolic status of glandular epithelial cells on auto-immunogenicity. J Autoimmun 104:102335","journal-title":"J Autoimmun"},{"key":"8793_CR5","doi-asserted-by":"crossref","first-page":"102301","DOI":"10.1016\/j.jaut.2019.06.012","volume":"103","author":"Y Pacheco","year":"2019","unstructured":"Pacheco Y et al (2019) Bystander activation and autoimmunity. J Autoimmun 103:102301","journal-title":"J Autoimmun"},{"key":"8793_CR6","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jaut.2017.09.007","volume":"86","author":"AG Vakrakou","year":"2018","unstructured":"Vakrakou AG et al (2018) Impaired anti-inflammatory activity of PPARgamma in the salivary epithelia of Sjogren\u2019s syndrome patients imposed by intrinsic NF-kappaB activation. J Autoimmun 86:62\u201374","journal-title":"J Autoimmun"},{"key":"8793_CR7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1749-6632.2009.04688.x","volume":"1171","author":"M Sisto","year":"2009","unstructured":"Sisto M et al (2009) Tumor necrosis factor inhibitors block apoptosis of human epithelial cells of the salivary glands. Ann N Y Acad Sci 1171:407\u2013414","journal-title":"Ann N Y Acad Sci"},{"key":"8793_CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2019.01.013","volume":"99","author":"D Long","year":"2019","unstructured":"Long D et al (2019) Clinical significance and immunobiology of IL-21 in autoimmunity. J Autoimmun 99:1\u201314","journal-title":"J Autoimmun"},{"issue":"3","key":"8793_CR9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jaut.2012.05.019","volume":"39","author":"N Singh","year":"2012","unstructured":"Singh N, Cohen PL (2012) The T cell in Sjogren\u2019s syndrome: force majeure, not spectateur. J Autoimmun 39(3):229\u2013233","journal-title":"J Autoimmun"},{"issue":"1","key":"8793_CR10","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4049\/jimmunol.130.1.203","volume":"130","author":"TC Adamson 3rd","year":"1983","unstructured":"Adamson TC 3rd et al (1983) Immunohistologic analysis of lymphoid infiltrates in primary Sjogren\u2019s syndrome using monoclonal antibodies. J Immunol 130(1):203\u2013208","journal-title":"J Immunol"},{"issue":"1","key":"8793_CR11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/art.40676","volume":"71","author":"CY Gao","year":"2019","unstructured":"Gao CY et al (2019) Tissue-resident memory CD8+ T cells acting as mediators of salivary gland damage in a murine model of Sjogren\u2019s syndrome. Arthritis Rheumatol 71(1):121\u2013132","journal-title":"Arthritis Rheumatol"},{"issue":"8","key":"8793_CR12","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/icb.2017.38","volume":"95","author":"JY Barr","year":"2017","unstructured":"Barr JY et al (2017) CD8 T cells contribute to lacrimal gland pathology in the nonobese diabetic mouse model of Sjogren syndrome. Immunol Cell Biol 95(8):684\u2013694","journal-title":"Immunol Cell Biol"},{"issue":"6","key":"8793_CR13","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/j.jaci.2016.01.024","volume":"137","author":"M Mingueneau","year":"2016","unstructured":"Mingueneau M et al (2016) Cytometry by time-of-flight immunophenotyping identifies a blood Sjogren\u2019s signature correlating with disease activity and glandular inflammation. J Allergy Clin Immunol 137(6):1809\u20131821 e12","journal-title":"J Allergy Clin Immunol"},{"issue":"8","key":"8793_CR14","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1136\/annrheumdis-2016-210788","volume":"76","author":"S Tasaki","year":"2017","unstructured":"Tasaki S et al (2017) Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjogren\u2019s syndrome. Ann Rheum Dis 76(8):1458\u20131466","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"8793_CR15","first-page":"726","volume":"31","author":"T Mandl","year":"2004","unstructured":"Mandl T et al (2004) CD4+ T-lymphocytopenia--a frequent finding in anti-SSA antibody seropositive patients with primary Sjogren\u2019s syndrome. J Rheumatol 31(4):726\u2013728","journal-title":"J Rheumatol"},{"issue":"2","key":"8793_CR16","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1365-2249.2012.04606.x","volume":"169","author":"T Maehara","year":"2012","unstructured":"Maehara T et al (2012) Selective localization of T helper subsets in labial salivary glands from primary Sjogren\u2019s syndrome patients. Clin Exp Immunol 169(2):89\u201399","journal-title":"Clin Exp Immunol"},{"issue":"10","key":"8793_CR17","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1136\/ard.2004.031781","volume":"64","author":"JM van Woerkom","year":"2005","unstructured":"van Woerkom JM et al (2005) Salivary gland and peripheral blood T helper 1 and 2 cell activity in Sjogren\u2019s syndrome compared with non-Sjogren\u2019s sicca syndrome. Ann Rheum Dis 64(10):1474\u20131479","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"8793_CR18","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1046\/j.1365-2249.2002.01869.x","volume":"128","author":"DI Mitsias","year":"2002","unstructured":"Mitsias DI et al (2002) The Th1\/Th2 cytokine balance changes with the progress of the immunopathological lesion of Sjogren\u2019s syndrome. Clin Exp Immunol 128(3):562\u2013568","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"8793_CR19","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s10238-004-0049-9","volume":"4","author":"R Bertorello","year":"2004","unstructured":"Bertorello R et al (2004) Increased levels of interleukin-10 in saliva of Sjogren\u2019s syndrome patients. Correlation with disease activity. Clin Exp Med 4(3):148\u2013151","journal-title":"Clin Exp Med"},{"issue":"1","key":"8793_CR20","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/1529-0131(200101)44:1<176::AID-ANR23>3.0.CO;2-K","volume":"44","author":"J Hulkkonen","year":"2001","unstructured":"Hulkkonen J et al (2001) Genetic association between interleukin-10 promoter region polymorphisms and primary Sjogren\u2019s syndrome. Arthritis Rheum 44(1):176\u2013179","journal-title":"Arthritis Rheum"},{"issue":"9","key":"8793_CR21","first-page":"1874","volume":"29","author":"JM Anaya","year":"2002","unstructured":"Anaya JM et al (2002) Interleukin 10 (IL-10) influences autoimmune response in primary Sjogren\u2019s syndrome and is linked to IL-10 gene polymorphism. J Rheumatol 29(9):1874\u20131876","journal-title":"J Rheumatol"},{"issue":"3","key":"8793_CR22","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s12016-018-8702-3","volume":"55","author":"A Blauvelt","year":"2018","unstructured":"Blauvelt A, Chiricozzi A (2018) The immunologic role of IL-17 in psoriasis and psoriatic arthritis pathogenesis. Clin Rev Allergy Immunol 55(3):379\u2013390","journal-title":"Clin Rev Allergy Immunol"},{"key":"8793_CR23","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jaut.2017.11.003","volume":"87","author":"GM Verstappen","year":"2018","unstructured":"Verstappen GM et al (2018) Th17 cells in primary Sjogren\u2019s syndrome: pathogenicity and plasticity. J Autoimmun 87:16\u201325","journal-title":"J Autoimmun"},{"issue":"3","key":"8793_CR24","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/1756-185X.12132","volume":"16","author":"G Azizi","year":"2013","unstructured":"Azizi G, Jadidi-Niaragh F, Mirshafiey A (2013) Th17 cells in immunopathogenesis and treatment of rheumatoid arthritis. Int J Rheum Dis 16(3):243\u2013253","journal-title":"Int J Rheum Dis"},{"issue":"4","key":"8793_CR25","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.4049\/jimmunol.181.4.2898","volume":"181","author":"A Sakai","year":"2008","unstructured":"Sakai A et al (2008) Identification of IL-18 and Th17 cells in salivary glands of patients with Sjogren\u2019s syndrome, and amplification of IL-17-mediated secretion of inflammatory cytokines from salivary gland cells by IL-18. J Immunol 181(4):2898\u20132906","journal-title":"J Immunol"},{"issue":"3","key":"8793_CR26","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/art.23214","volume":"58","author":"CQ Nguyen","year":"2008","unstructured":"Nguyen CQ et al (2008) Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjogren\u2019s syndrome: findings in humans and mice. Arthritis Rheum 58(3):734\u2013743","journal-title":"Arthritis Rheum"},{"key":"8793_CR27","doi-asserted-by":"crossref","unstructured":"Xiao F et al (2017) Proteasome inhibition suppresses Th17 cell generation and ameliorates autoimmune development in experimental Sjogren\u2019s syndrome. Cell Mol Immunol","DOI":"10.1038\/cmi.2017.8"},{"issue":"4","key":"8793_CR28","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.immuni.2014.10.004","volume":"41","author":"S Crotty","year":"2014","unstructured":"Crotty S (2014) T follicular helper cell differentiation, function, and roles in disease. Immunity 41(4):529\u2013542","journal-title":"Immunity"},{"issue":"Suppl 2","key":"8793_CR29","first-page":"180","volume":"76","author":"E Pontarini","year":"2017","unstructured":"Pontarini E et al (2017) OP0300\u00a0enrichment of T follicular-helper cells (TFH) and exclusion of t follicular-regulatory cells (TFR) from ectoPIC germinal centers in salivary glands of Sjogren\u2019s syndrome patients. Ann Rheum Dis 76(Suppl 2):180\u2013180","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"8793_CR30","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/art.40424","volume":"70","author":"VR Fonseca","year":"2018","unstructured":"Fonseca VR et al (2018) The ratio of blood T follicular regulatory cells to T follicular helper cells marks ectopic lymphoid structure formation while activated follicular helper T cells indicate disease activity in primary Sjogren\u2019s syndrome. Arthritis Rheumatol 70(5):774\u2013784","journal-title":"Arthritis Rheumatol"},{"issue":"8","key":"8793_CR31","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1002\/art.40488","volume":"70","author":"GM Verstappen","year":"2018","unstructured":"Verstappen GM et al (2018) Is the T follicular regulatory:follicular helper T cell ratio in blood a biomarker for ectopic lymphoid structure formation in Sjogren\u2019s syndrome? Comment on the article by Fonseca et al. Arthritis Rheumatol 70(8):1354\u20131355","journal-title":"Arthritis Rheumatol"},{"issue":"2","key":"8793_CR32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.clim.2013.02.024","volume":"147","author":"K Szabo","year":"2013","unstructured":"Szabo K et al (2013) Follicular helper T cells may play an important role in the severity of primary Sjogren\u2019s syndrome. Clin Immunol 147(2):95\u2013104","journal-title":"Clin Immunol"},{"issue":"5","key":"8793_CR33","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1084\/jem.20090313","volume":"206","author":"IL King","year":"2009","unstructured":"King IL, Mohrs M (2009) IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells. J Exp Med 206(5):1001\u20131007","journal-title":"J Exp Med"},{"issue":"3","key":"8793_CR34","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jaut.2005.01.015","volume":"24","author":"JE Gottenberg","year":"2005","unstructured":"Gottenberg JE et al (2005) CD4 CD25high regulatory T cells are not impaired in patients with primary Sjogren\u2019s syndrome. J Autoimmun 24(3):235\u2013242","journal-title":"J Autoimmun"},{"issue":"12","key":"8793_CR35","first-page":"2438","volume":"34","author":"X Li","year":"2007","unstructured":"Li X et al (2007) T regulatory cells are markedly diminished in diseased salivary glands of patients with primary Sjogren\u2019s syndrome. J Rheumatol 34(12):2438\u20132445","journal-title":"J Rheumatol"},{"issue":"5","key":"8793_CR36","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.2353\/ajpath.2008.080246","volume":"173","author":"MI Christodoulou","year":"2008","unstructured":"Christodoulou MI et al (2008) Foxp3+ T-regulatory cells in Sjogren\u2019s syndrome: correlation with the grade of the autoimmune lesion and certain adverse prognostic factors. Am J Pathol 173(5):1389\u20131396","journal-title":"Am J Pathol"},{"issue":"1","key":"8793_CR37","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1177\/0961203307085248","volume":"17","author":"MF Liu","year":"2008","unstructured":"Liu MF et al (2008) Decreased CD4+CD25+bright T cells in peripheral blood of patients with primary Sjogren\u2019s syndrome. Lupus 17(1):34\u201339","journal-title":"Lupus"},{"issue":"2","key":"8793_CR38","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1177\/0961203309348234","volume":"19","author":"M Sarigul","year":"2010","unstructured":"Sarigul M et al (2010) The numbers of Foxp3 + Treg cells are positively correlated with higher grade of infiltration at the salivary glands in primary Sjogren\u2019s syndrome. Lupus 19(2):138\u2013145","journal-title":"Lupus"},{"issue":"8","key":"8793_CR39","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1093\/rheumatology\/ket179","volume":"52","author":"A Alunno","year":"2013","unstructured":"Alunno A et al (2013) Characterization of a new regulatory CD4+ T cell subset in primary Sjogren\u2019s syndrome. Rheumatology (Oxford) 52(8):1387\u20131396","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"8793_CR40","doi-asserted-by":"crossref","first-page":"R68","DOI":"10.1186\/ar4245","volume":"15","author":"J Furuzawa-Carballeda","year":"2013","unstructured":"Furuzawa-Carballeda J et al (2013) Peripheral regulatory cells immunophenotyping in primary Sjogren\u2019s syndrome: a cross-sectional study. Arthritis Res Ther 15(3):R68","journal-title":"Arthritis Res Ther"},{"issue":"7","key":"8793_CR41","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1002\/art.39629","volume":"68","author":"NI Maria","year":"2016","unstructured":"Maria NI et al (2016) Association of increased Treg cell levels with elevated indoleamine 2,3-dioxygenase activity and an imbalanced kynurenine pathway in interferon-positive primary Sjogren\u2019s syndrome. Arthritis Rheumatol 68(7):1688\u20131699","journal-title":"Arthritis Rheumatol"},{"issue":"5","key":"8793_CR42","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.4049\/jimmunol.176.5.2808","volume":"176","author":"G Raimondi","year":"2006","unstructured":"Raimondi G et al (2006) Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells. J Immunol 176(5):2808\u20132816","journal-title":"J Immunol"},{"issue":"1","key":"8793_CR43","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1136\/mp.56.1.52","volume":"56","author":"GI Mason","year":"2003","unstructured":"Mason GI et al (2003) Salivary gland expression of transforming growth factor beta isoforms in Sjogren\u2019s syndrome and benign lymphoepithelial lesions. Mol Pathol 56(1):52\u201359","journal-title":"Mol Pathol"},{"issue":"6","key":"8793_CR44","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.autrev.2013.12.004","volume":"13","author":"M Noack","year":"2014","unstructured":"Noack M, Miossec P (2014) Th17 and regulatory T cell balance in autoimmune and inflammatory diseases. Autoimmun Rev 13(6):668\u2013677","journal-title":"Autoimmun Rev"},{"issue":"5","key":"8793_CR45","doi-asserted-by":"crossref","first-page":"293","DOI":"10.4081\/reumatismo.2012.293","volume":"64","author":"A Alunno","year":"2012","unstructured":"Alunno A et al (2012) Expansion of CD4+CD25-GITR+ regulatory T-cell subset in the peripheral blood of patients with primary Sjogren\u2019s syndrome: correlation with disease activity. Reumatismo 64(5):293\u2013298","journal-title":"Reumatismo"},{"issue":"4","key":"8793_CR46","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1080\/14397595.2016.1226470","volume":"27","author":"C Liu","year":"2017","unstructured":"Liu C et al (2017) Elevated level of circulating CD4(+)Helios(+)FoxP3(+) cells in primary Sjogren\u2019s syndrome patients. Mod Rheumatol 27(4):630\u2013637","journal-title":"Mod Rheumatol"},{"issue":"5","key":"8793_CR47","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.autrev.2012.10.006","volume":"12","author":"Y Yao","year":"2013","unstructured":"Yao Y et al (2013) Type I interferons in Sjogren\u2019s syndrome. Autoimmun Rev 12(5):558\u2013566","journal-title":"Autoimmun Rev"},{"issue":"2","key":"8793_CR48","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/art.23191","volume":"58","author":"TB Niewold","year":"2008","unstructured":"Niewold TB et al (2008) Serum type I interferon activity is dependent on maternal diagnosis in anti-SSA\/Ro-positive mothers of children with neonatal lupus. Arthritis Rheum 58(2):541\u2013546","journal-title":"Arthritis Rheum"},{"issue":"8","key":"8793_CR49","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1073\/pnas.0510837103","volume":"103","author":"JE Gottenberg","year":"2006","unstructured":"Gottenberg JE et al (2006) Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjogren\u2019s syndrome. Proc Natl Acad Sci U S A 103(8):2770\u20132775","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"23","key":"8793_CR50","doi-asserted-by":"crossref","first-page":"7225","DOI":"10.1073\/pnas.1508224112","volume":"112","author":"M Miyara","year":"2015","unstructured":"Miyara M et al (2015) Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3high regulatory T cells in humans. Proc Natl Acad Sci U S A 112(23):7225\u20137230","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Suppl 2","key":"8793_CR51","first-page":"876","volume":"77","author":"G Yao","year":"2018","unstructured":"Yao G, Qi J, Sun L (2018) SAT0016\u00a0Il-12 suppress tr1 cells in the sj\u00d6gren\u2019s syndrome. Ann Rheum Dis 77(Suppl 2):876\u2013876","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"8793_CR52","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2011.03.018","volume":"34","author":"A Chaudhry","year":"2011","unstructured":"Chaudhry A et al (2011) Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity 34(4):566\u2013578","journal-title":"Immunity"},{"issue":"8","key":"8793_CR53","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nm.2425","volume":"17","author":"MA Linterman","year":"2011","unstructured":"Linterman MA et al (2011) Foxp3+ follicular regulatory T cells control the germinal center response. Nat Med 17(8):975\u2013982","journal-title":"Nat Med"},{"key":"8793_CR54","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.3389\/fimmu.2018.01536","volume":"9","author":"MM Xie","year":"2018","unstructured":"Xie MM, Dent AL (2018) Unexpected help: follicular regulatory T cells in the germinal center. Front Immunol 9:1536","journal-title":"Front Immunol"},{"key":"8793_CR55","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.intimp.2018.01.038","volume":"56","author":"C Liu","year":"2018","unstructured":"Liu C et al (2018) Increased circulating CD4(+)CXCR5(+)FoxP3(+) follicular regulatory T cells correlated with severity of systemic lupus erythematosus patients. Int Immunopharmacol 56:261\u2013268","journal-title":"Int Immunopharmacol"},{"key":"8793_CR56","doi-asserted-by":"crossref","unstructured":"Fonseca VR et al (2017) Human blood Tfr cells are indicators of ongoing humoral activity not fully licensed with suppressive function. Sci Immunol 2(14)","DOI":"10.1126\/sciimmunol.aan1487"},{"issue":"1","key":"8793_CR57","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/imm.12774","volume":"152","author":"AR Maceiras","year":"2017","unstructured":"Maceiras AR et al (2017) T follicular regulatory cells in mice and men. Immunology 152(1):25\u201335","journal-title":"Immunology"},{"issue":"12","key":"8793_CR58","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.1172\/JCI76861","volume":"124","author":"PT Sage","year":"2014","unstructured":"Sage PT et al (2014) Circulating T follicular regulatory and helper cells have memory-like properties. J Clin Invest 124(12):5191\u20135204","journal-title":"J Clin Invest"},{"issue":"38","key":"8793_CR59","doi-asserted-by":"crossref","first-page":"9604","DOI":"10.1073\/pnas.1808594115","volume":"115","author":"PG Ritvo","year":"2018","unstructured":"Ritvo PG et al (2018) High-resolution repertoire analysis reveals a major bystander activation of Tfh and Tfr cells. Proc Natl Acad Sci U S A 115(38):9604\u20139609","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8793_CR60","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.3389\/fimmu.2018.02899","volume":"9","author":"I Cosorich","year":"2018","unstructured":"Cosorich I et al (2018) CCR9 expressing T helper and T follicular helper cells exhibit site-specific identities during inflammatory disease. Front Immunol 9:2899","journal-title":"Front Immunol"},{"issue":"4","key":"8793_CR61","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.immuni.2011.01.021","volume":"34","author":"HM McGuire","year":"2011","unstructured":"McGuire HM et al (2011) A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunity. Immunity 34(4):602\u2013615","journal-title":"Immunity"},{"issue":"10","key":"8793_CR62","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1002\/art.40182","volume":"69","author":"SLM Blokland","year":"2017","unstructured":"Blokland SLM et al (2017) Increased CCL25 and T helper cells expressing CCR9 in the salivary glands of patients with primary Sjogren\u2019s syndrome: potential new axis in lymphoid neogenesis. Arthritis Rheumatol 69(10):2038\u20132051","journal-title":"Arthritis Rheumatol"},{"issue":"5802","key":"8793_CR63","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1126\/science.1132742","volume":"314","author":"JR Mora","year":"2006","unstructured":"Mora JR et al (2006) Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science 314(5802):1157\u20131160","journal-title":"Science"},{"key":"8793_CR64","first-page":"1273","volume":"77","author":"S Blokland","year":"2018","unstructured":"Blokland S et al (2018) Ccr9+pathogenic Thelper cells from primary Sjogren\u2019s syndrome patients are characterised by deregulated pathways associated with effector T cell function. Ann Rheum Dis 77:1273\u20131273","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"8793_CR65","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nri.2015.3","volume":"16","author":"SN Mueller","year":"2016","unstructured":"Mueller SN, Mackay LK (2016) Tissue-resident memory T cells: local specialists in immune defence. Nat Rev Immunol 16(2):79\u201389","journal-title":"Nat Rev Immunol"},{"issue":"12","key":"8793_CR66","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/ni.2744","volume":"14","author":"LK Mackay","year":"2013","unstructured":"Mackay LK et al (2013) The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin. Nat Immunol 14(12):1294\u20131301","journal-title":"Nat Immunol"},{"issue":"6","key":"8793_CR67","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.celrep.2015.09.082","volume":"13","author":"JT Thom","year":"2015","unstructured":"Thom JT et al (2015) The salivary gland acts as a sink for tissue-resident memory CD8(+) T cells, facilitating protection from local cytomegalovirus infection. Cell Rep 13(6):1125\u20131136","journal-title":"Cell Rep"},{"issue":"12","key":"8793_CR68","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1016\/j.celrep.2017.08.078","volume":"20","author":"BV Kumar","year":"2017","unstructured":"Kumar BV et al (2017) Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites. Cell Rep 20(12):2921\u20132934","journal-title":"Cell Rep"},{"key":"8793_CR69","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev-immunol-020711-075011","volume":"30","author":"JG Cyster","year":"2012","unstructured":"Cyster JG, Schwab SR (2012) Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs. Annu Rev Immunol 30:69\u201394","journal-title":"Annu Rev Immunol"},{"issue":"12","key":"8793_CR70","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/ni.2745","volume":"14","author":"CN Skon","year":"2013","unstructured":"Skon CN et al (2013) Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells. Nat Immunol 14(12):1285\u20131293","journal-title":"Nat Immunol"},{"issue":"4","key":"8793_CR71","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.autrev.2018.02.001","volume":"17","author":"D Brandt","year":"2018","unstructured":"Brandt D, Hedrich CM (2018) TCRalphabeta(+)CD3(+)CD4(\u2212)CD8(\u2212) (double negative) T cells in autoimmunity. Autoimmun Rev 17(4):422\u2013430","journal-title":"Autoimmun Rev"},{"issue":"2","key":"8793_CR72","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1136\/annrheumdis-2012-201511","volume":"72","author":"A Alunno","year":"2013","unstructured":"Alunno A et al (2013) IL-17-producing CD4-CD8- T cells are expanded in the peripheral blood, infiltrate salivary glands and are resistant to corticosteroids in patients with primary Sjogren\u2019s syndrome. Ann Rheum Dis 72(2):286\u2013292","journal-title":"Ann Rheum Dis"},{"key":"8793_CR73","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jaut.2014.01.030","volume":"51","author":"A Alunno","year":"2014","unstructured":"Alunno A et al (2014) CD4(-)CD8(-) T-cells in primary Sjogren\u2019s syndrome: association with the extent of glandular involvement. J Autoimmun 51:38\u201343","journal-title":"J Autoimmun"},{"issue":"1","key":"8793_CR74","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.clim.2014.10.007","volume":"156","author":"PA Renauer","year":"2015","unstructured":"Renauer PA, Coit P, Sawalha AH (2015) The DNA methylation signature of human TCRalphabeta+CD4-CD8- double negative T cells reveals CG demethylation and a unique epigenetic architecture permissive to a broad stimulatory immune response. Clin Immunol 156(1):19\u201327","journal-title":"Clin Immunol"},{"issue":"7","key":"8793_CR75","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.4049\/jimmunol.0901533","volume":"183","author":"JC Crispin","year":"2009","unstructured":"Crispin JC, Tsokos GC (2009) Human TCR-alpha beta+ CD4- CD8- T cells can derive from CD8+ T cells and display an inflammatory effector phenotype. J Immunol 183(7):4675\u20134681","journal-title":"J Immunol"},{"key":"8793_CR76","first-page":"302","volume":"6","author":"Y Gao","year":"2015","unstructured":"Gao Y, Williams AP (2015) Role of innate T cells in anti-bacterial immunity. Front Immunol 6:302","journal-title":"Front Immunol"},{"issue":"3","key":"8793_CR77","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/cmi.2008.20","volume":"5","author":"R Casetti","year":"2008","unstructured":"Casetti R, Martino A (2008) The plasticity of gamma delta T cells: innate immunity, antigen presentation and new immunotherapy. Cell Mol Immunol 5(3):161\u2013170","journal-title":"Cell Mol Immunol"},{"issue":"2","key":"8793_CR78","first-page":"175","volume":"77","author":"F Brennan","year":"1989","unstructured":"Brennan F et al (1989) Coordinate expansion of \u2018fetal type\u2019 lymphocytes (TCR gamma delta+T and CD5+B) in rheumatoid arthritis and primary Sjogren\u2019s syndrome. Clin Exp Immunol 77(2):175\u2013178","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"8793_CR79","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF00262708","volume":"15","author":"A Caretto","year":"1995","unstructured":"Caretto A et al (1995) An immunohistochemical study of immunological phenomena in minor salivary glands in patients with Sjogren\u2019s syndrome. Rheumatol Int 15(2):51\u201355","journal-title":"Rheumatol Int"},{"issue":"10","key":"8793_CR80","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1002\/eji.201646300","volume":"46","author":"JJ Wang","year":"2016","unstructured":"Wang JJ et al (2016) Mucosal-associated invariant T cells are reduced and functionally immature in the peripheral blood of primary Sjogren\u2019s syndrome patients. Eur J Immunol 46(10):2444\u20132453","journal-title":"Eur J Immunol"},{"key":"8793_CR81","doi-asserted-by":"crossref","first-page":"4328372","DOI":"10.1155\/2016\/4328372","volume":"2016","author":"G Papp","year":"2016","unstructured":"Papp G et al (2016) Increased IL-21 expression induces granzyme B in peripheral CD5(+) B cells as a potential counter-regulatory effect in primary Sjogren\u2019s syndrome. Mediat Inflamm 2016:4328372","journal-title":"Mediat Inflamm"},{"issue":"3","key":"8793_CR82","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.coi.2010.02.013","volume":"22","author":"JM Curtsinger","year":"2010","unstructured":"Curtsinger JM, Mescher MF (2010) Inflammatory cytokines as a third signal for T cell activation. Curr Opin Immunol 22(3):333\u2013340","journal-title":"Curr Opin Immunol"},{"key":"8793_CR83","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.0105-2896.2006.00382.x","volume":"211","author":"MF Mescher","year":"2006","unstructured":"Mescher MF et al (2006) Signals required for programming effector and memory development by CD8+ T cells. Immunol Rev 211:81\u201392","journal-title":"Immunol Rev"},{"key":"8793_CR84","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3389\/fimmu.2017.00204","volume":"8","author":"SL Bevington","year":"2017","unstructured":"Bevington SL et al (2017) T cell receptor and cytokine signaling can function at different stages to establish and maintain transcriptional memory and enable T helper cell differentiation. Front Immunol 8:204","journal-title":"Front Immunol"},{"issue":"4","key":"8793_CR85","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nri3405","volume":"13","author":"L Chen","year":"2013","unstructured":"Chen L, Flies DB (2013) Molecular mechanisms of T cell co-stimulation and co-inhibition. Nat Rev Immunol 13(4):227\u2013242","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"8793_CR86","doi-asserted-by":"crossref","first-page":"11044","DOI":"10.1038\/s41598-018-29411-9","volume":"8","author":"MC Edman","year":"2018","unstructured":"Edman MC et al (2018) Increased cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjogren\u2019s syndrome patients. Sci Rep 8(1):11044","journal-title":"Sci Rep"},{"issue":"7","key":"8793_CR87","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1002\/art.38633","volume":"66","author":"SF Hamm-Alvarez","year":"2014","unstructured":"Hamm-Alvarez SF et al (2014) Tear cathepsin S as a candidate biomarker for Sjogren\u2019s syndrome. Arthritis Rheumatol 66(7):1872\u20131881","journal-title":"Arthritis Rheumatol"},{"issue":"Suppl 2","key":"8793_CR88","first-page":"684","volume":"77","author":"P Hargreaves","year":"2018","unstructured":"Hargreaves P et al (2018) FRI0295\u00a0inhibition of cathepsin s leads to suppression of antigen specific t cells from patients with primary sj\u00d6gren syndrome. Ann Rheum Dis 77(Suppl 2):684\u2013684","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"8793_CR89","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1586\/1744666X.2014.900441","volume":"10","author":"D Zhou","year":"2014","unstructured":"Zhou D, McNamara NA (2014) Macrophages: important players in primary Sjogren\u2019s syndrome? Expert Rev Clin Immunol 10(4):513\u2013520","journal-title":"Expert Rev Clin Immunol"},{"issue":"12","key":"8793_CR90","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1002\/art.23073","volume":"56","author":"MN Manoussakis","year":"2007","unstructured":"Manoussakis MN et al (2007) Rates of infiltration by macrophages and dendritic cells and expression of interleukin-18 and interleukin-12 in the chronic inflammatory lesions of Sjogren\u2019s syndrome: correlation with certain features of immune hyperactivity and factors associated with high risk of lymphoma development. Arthritis Rheum 56(12):3977\u20133988","journal-title":"Arthritis Rheum"},{"issue":"4","key":"8793_CR91","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1586\/1744666X.2014.878650","volume":"10","author":"MR Hillen","year":"2014","unstructured":"Hillen MR et al (2014) Dendritic cells, T-cells and epithelial cells: a crucial interplay in immunopathology of primary Sjogren\u2019s syndrome. Expert Rev Clin Immunol 10(4):521\u2013531","journal-title":"Expert Rev Clin Immunol"},{"issue":"3","key":"8793_CR92","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1136\/ard.2008.087874","volume":"68","author":"ME Wildenberg","year":"2009","unstructured":"Wildenberg ME et al (2009) Increased frequency of CD16+ monocytes and the presence of activated dendritic cells in salivary glands in primary Sjogren syndrome. Ann Rheum Dis 68(3):420\u2013426","journal-title":"Ann Rheum Dis"},{"issue":"40","key":"8793_CR93","doi-asserted-by":"crossref","first-page":"E8430","DOI":"10.1073\/pnas.1708125114","volume":"114","author":"R Hurdayal","year":"2017","unstructured":"Hurdayal R et al (2017) IL-4-producing B cells regulate T helper cell dichotomy in type 1- and type 2-controlled diseases. Proc Natl Acad Sci U S A 114(40):E8430\u2013E8439","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8793_CR94","doi-asserted-by":"crossref","unstructured":"Jelcic I et al (2018) Memory B cells activate brain-homing, autoreactive CD4(+) T cells in multiple sclerosis. Cell","DOI":"10.1016\/j.cell.2018.08.011"},{"issue":"4","key":"8793_CR95","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.4049\/jimmunol.164.4.1658","volume":"164","author":"OT Chan","year":"2000","unstructured":"Chan OT, Shlomchik MJ (2000) Cutting edge: B cells promote CD8+ T cell activation in MRL-Fas(lpr) mice independently of MHC class I antigen presentation. J Immunol 164(4):1658\u20131662","journal-title":"J Immunol"},{"issue":"6","key":"8793_CR96","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0003-9969(02)00025-0","volume":"47","author":"C McArthur","year":"2002","unstructured":"McArthur C et al (2002) Intracellular trafficking and surface expression of SS-A (Ro), SS-B (La), poly(ADP-ribose) polymerase and alpha-fodrin autoantigens during apoptosis in human salivary gland cells induced by tumour necrosis factor-alpha. Arch Oral Biol 47(6):443\u2013448","journal-title":"Arch Oral Biol"},{"issue":"5","key":"8793_CR97","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1002\/art.21005","volume":"52","author":"EK Kapsogeorgou","year":"2005","unstructured":"Kapsogeorgou EK et al (2005) Salivary gland epithelial cell exosomes: a source of autoantigenic ribonucleoproteins. Arthritis Rheum 52(5):1517\u20131521","journal-title":"Arthritis Rheum"},{"issue":"3","key":"8793_CR98","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/cei.13077","volume":"191","author":"M Ainola","year":"2018","unstructured":"Ainola M et al (2018) Activation of plasmacytoid dendritic cells by apoptotic particles - mechanism for the loss of immunological tolerance in Sjogren\u2019s syndrome. Clin Exp Immunol 191(3):301\u2013310","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"8793_CR99","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ni911","volume":"4","author":"L Hunziker","year":"2003","unstructured":"Hunziker L et al (2003) Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections. Nat Immunol 4(4):343\u2013349","journal-title":"Nat Immunol"},{"issue":"5","key":"8793_CR100","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.4049\/jimmunol.166.5.3107","volume":"166","author":"EK Kapsogeorgou","year":"2001","unstructured":"Kapsogeorgou EK, Moutsopoulos HM, Manoussakis MN (2001) Functional expression of a costimulatory B7.2 (CD86) protein on human salivary gland epithelial cells that interacts with the CD28 receptor, but has reduced binding to CTLA4. J Immunol 166(5):3107\u20133113","journal-title":"J Immunol"},{"issue":"3","key":"8793_CR101","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1365-2249.2006.03311.x","volume":"147","author":"MP Spachidou","year":"2007","unstructured":"Spachidou MP et al (2007) Expression of functional toll-like receptors by salivary gland epithelial cells: increased mRNA expression in cells derived from patients with primary Sjogren\u2019s syndrome. Clin Exp Immunol 147(3):497\u2013503","journal-title":"Clin Exp Immunol"},{"key":"8793_CR102","doi-asserted-by":"crossref","first-page":"16047","DOI":"10.1038\/nrdp.2016.47","volume":"2","author":"P Brito-Zeron","year":"2016","unstructured":"Brito-Zeron P et al (2016) Sjogren syndrome. Nat Rev Dis Primers 2:16047","journal-title":"Nat Rev Dis Primers"},{"issue":"4","key":"8793_CR103","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1517\/14728222.2013.754427","volume":"17","author":"A Yamada","year":"2013","unstructured":"Yamada A et al (2013) Targeting IL-1 in Sjogren\u2019s syndrome. Expert Opin Ther Targets 17(4):393\u2013401","journal-title":"Expert Opin Ther Targets"},{"issue":"9","key":"8793_CR104","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nrrheum.2013.110","volume":"9","author":"G Nocturne","year":"2013","unstructured":"Nocturne G, Mariette X (2013) Advances in understanding the pathogenesis of primary Sjogren\u2019s syndrome. Nat Rev Rheumatol 9(9):544\u2013556","journal-title":"Nat Rev Rheumatol"},{"issue":"10","key":"8793_CR105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045689","volume":"7","author":"T Kawanami","year":"2012","unstructured":"Kawanami T et al (2012) Skewed production of IL-6 and TGFbeta by cultured salivary gland epithelial cells from patients with Sjogren\u2019s syndrome. PLoS One 7(10):e45689","journal-title":"PLoS One"},{"issue":"6","key":"8793_CR106","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1136\/annrheumdis-2011-200744","volume":"71","author":"A Bikker","year":"2012","unstructured":"Bikker A et al (2012) Increased interleukin (IL)-7Ralpha expression in salivary glands of patients with primary Sjogren\u2019s syndrome is restricted to T cells and correlates with IL-7 expression, lymphocyte numbers and activity. Ann Rheum Dis 71(6):1027\u20131033","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"8793_CR107","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1002\/art.38007","volume":"65","author":"JO Jin","year":"2013","unstructured":"Jin JO et al (2013) Interleukin-7 enhances the Th1 response to promote the development of Sjogren\u2019s syndrome-like autoimmune exocrinopathy in mice. Arthritis Rheum 65(8):2132\u20132142","journal-title":"Arthritis Rheum"},{"issue":"12","key":"8793_CR108","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1002\/art.24980","volume":"60","author":"JL Vosters","year":"2009","unstructured":"Vosters JL et al (2009) Interleukin-12 induces salivary gland dysfunction in transgenic mice, providing a new model of Sjogren\u2019s syndrome. Arthritis Rheum 60(12):3633\u20133641","journal-title":"Arthritis Rheum"},{"issue":"12","key":"8793_CR109","doi-asserted-by":"crossref","first-page":"8576","DOI":"10.4049\/jimmunol.181.12.8576","volume":"181","author":"CJ Henry","year":"2008","unstructured":"Henry CJ et al (2008) IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17. J Immunol 181(12):8576\u20138584","journal-title":"J Immunol"},{"issue":"4","key":"8793_CR110","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/ar3348","volume":"13","author":"P Youinou","year":"2011","unstructured":"Youinou P, Pers JO (2011) Disturbance of cytokine networks in Sjogren\u2019s syndrome. Arthritis Res Ther 13(4):227","journal-title":"Arthritis Res Ther"},{"key":"8793_CR111","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jaut.2013.11.003","volume":"51","author":"YZ Gong","year":"2014","unstructured":"Gong YZ et al (2014) Differentiation of follicular helper T cells by salivary gland epithelial cells in primary Sjogren\u2019s syndrome. J Autoimmun 51:57\u201366","journal-title":"J Autoimmun"},{"issue":"9","key":"8793_CR112","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/ni.2947","volume":"15","author":"N Schmitt","year":"2014","unstructured":"Schmitt N et al (2014) The cytokine TGF-beta co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells. Nat Immunol 15(9):856\u2013865","journal-title":"Nat Immunol"},{"issue":"9","key":"8793_CR113","first-page":"1884","volume":"29","author":"S Tsunawaki","year":"2002","unstructured":"Tsunawaki S et al (2002) Possible function of salivary gland epithelial cells as nonprofessional antigen-presenting cells in the development of Sjogren\u2019s syndrome. J Rheumatol 29(9):1884\u20131896","journal-title":"J Rheumatol"},{"key":"8793_CR114","doi-asserted-by":"crossref","first-page":"278948","DOI":"10.1155\/2010\/278948","volume":"2010","author":"OJ Baker","year":"2010","unstructured":"Baker OJ (2010) Tight junctions in salivary epithelium. J Biomed Biotechnol 2010:278948","journal-title":"J Biomed Biotechnol"},{"issue":"2","key":"8793_CR115","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1006\/jaut.2001.0524","volume":"17","author":"RF Abu-Helu","year":"2001","unstructured":"Abu-Helu RF et al (2001) Induction of salivary gland epithelial cell injury in Sjogren\u2019s syndrome: in vitro assessment of T cell-derived cytokines and Fas protein expression. J Autoimmun 17(2):141\u2013153","journal-title":"J Autoimmun"},{"issue":"4","key":"8793_CR116","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/labinvest.2016.141","volume":"97","author":"J Zhou","year":"2017","unstructured":"Zhou J, Kawai T, Yu Q (2017) Pathogenic role of endogenous TNF-alpha in the development of Sjogren\u2019s-like sialadenitis and secretory dysfunction in non-obese diabetic mice. Lab Investig 97(4):458\u2013467","journal-title":"Lab Investig"},{"issue":"6","key":"8793_CR117","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1177\/0022034519837240","volume":"98","author":"A Limaye","year":"2019","unstructured":"Limaye A et al (2019) Targeted TNF-alpha overexpression drives salivary gland inflammation. J Dent Res 98(6):713\u2013719","journal-title":"J Dent Res"},{"issue":"11","key":"8793_CR118","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1136\/ard.54.11.904","volume":"54","author":"T Dorner","year":"1995","unstructured":"Dorner T et al (1995) Enhanced membrane expression of the 52 kDa Ro(SS-A) and La(SS-B) antigens by human keratinocytes induced by TNF alpha. Ann Rheum Dis 54(11):904\u2013909","journal-title":"Ann Rheum Dis"},{"issue":"12","key":"8793_CR119","doi-asserted-by":"crossref","first-page":"7467","DOI":"10.4049\/jimmunol.1001519","volume":"185","author":"M Esposito","year":"2010","unstructured":"Esposito M et al (2010) IL-17- and IFN-gamma-secreting Foxp3+ T cells infiltrate the target tissue in experimental autoimmunity. J Immunol 185(12):7467\u20137473","journal-title":"J Immunol"},{"key":"8793_CR120","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.3389\/fimmu.2018.01755","volume":"9","author":"J Luo","year":"2018","unstructured":"Luo J et al (2018) IL-2 inhibition of Th17 generation rather than induction of Treg cells is impaired in primary Sjogren\u2019s syndrome patients. Front Immunol 9:1755","journal-title":"Front Immunol"},{"issue":"12","key":"8793_CR121","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1136\/annrheumdis-2018-213036","volume":"77","author":"M Miao","year":"2018","unstructured":"Miao M et al (2018) Short-term and low-dose IL-2 therapy restores the Th17\/Treg balance in the peripheral blood of patients with primary Sjogren\u2019s syndrome. Ann Rheum Dis 77(12):1838\u20131840","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"8793_CR122","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jaut.2005.11.004","volume":"26","author":"J Gao","year":"2006","unstructured":"Gao J et al (2006) Sjogren\u2019s syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease. J Autoimmun 26(2):90\u2013103","journal-title":"J Autoimmun"},{"issue":"6","key":"8793_CR123","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nrrheum.2014.225","volume":"11","author":"SK Kwok","year":"2015","unstructured":"Kwok SK et al (2015) A pathogenetic role for IL-21 in primary Sjogren syndrome. Nat Rev Rheumatol 11(6):368\u2013374","journal-title":"Nat Rev Rheumatol"},{"issue":"10","key":"8793_CR124","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/j.1600-0714.2012.01175.x","volume":"41","author":"H Liu","year":"2012","unstructured":"Liu H et al (2012) Local suppression of IL-21 in submandibular glands retards the development of Sjogren\u2019s syndrome in non-obese diabetic mice. J Oral Pathol Med 41(10):728\u2013735","journal-title":"J Oral Pathol Med"},{"issue":"3","key":"8793_CR125","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.4049\/jimmunol.180.3.1921","volume":"180","author":"M Sekiguchi","year":"2008","unstructured":"Sekiguchi M et al (2008) Role of sphingosine 1-phosphate in the pathogenesis of Sjogren\u2019s syndrome. J Immunol 180(3):1921\u20131928","journal-title":"J Immunol"},{"issue":"35","key":"8793_CR126","doi-asserted-by":"crossref","first-page":"11024","DOI":"10.1073\/pnas.1503315112","volume":"112","author":"F Barone","year":"2015","unstructured":"Barone F et al (2015) IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs. Proc Natl Acad Sci U S A 112(35):11024\u201311029","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"8793_CR127","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1365-3083.2011.02583.x","volume":"74","author":"TN Lavoie","year":"2011","unstructured":"Lavoie TN et al (2011) Expression of interleukin-22 in Sjogren\u2019s syndrome: significant correlation with disease parameters. Scand J Immunol 74(4):377\u2013382","journal-title":"Scand J Immunol"},{"issue":"2","key":"8793_CR128","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1136\/ard.2011.154013","volume":"71","author":"F Ciccia","year":"2012","unstructured":"Ciccia F et al (2012) Potential involvement of IL-22 and IL-22-producing cells in the inflamed salivary glands of patients with Sjogren\u2019s syndrome. Ann Rheum Dis 71(2):295\u2013301","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"8793_CR129","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1586\/1744666X.2014.884461","volume":"10","author":"F Ciccia","year":"2014","unstructured":"Ciccia F et al (2014) The role of innate and lymphoid IL-22-producing cells in the immunopathology of primary Sjogren\u2019s syndrome. Expert Rev Clin Immunol 10(4):533\u2013541","journal-title":"Expert Rev Clin Immunol"},{"issue":"1 Supplement","key":"8793_CR130","doi-asserted-by":"crossref","first-page":"41.15","DOI":"10.4049\/jimmunol.200.Supp.41.15","volume":"200","author":"B Yoo","year":"2018","unstructured":"Yoo B, Zhou J, Yu Q (2018) A detrimental effect of interleukin-22 on salivary gland tissue integrity and function. J Immunol 200(1 Supplement):41.15\u201341.15","journal-title":"J Immunol"},{"issue":"3","key":"8793_CR131","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.2353\/ajpath.2009.090319","volume":"175","author":"GE Katsifis","year":"2009","unstructured":"Katsifis GE et al (2009) Systemic and local interleukin-17 and linked cytokines associated with Sjogren\u2019s syndrome immunopathogenesis. Am J Pathol 175(3):1167\u20131177","journal-title":"Am J Pathol"},{"key":"8793_CR132","unstructured":"Yao G, Shi B., Qi J, Wang Y, Chen W, Tang X, Wang D, Feng X, Sun L (2015) Deficiency of IL-27 exacerbate Sj\u00f6gren\u2019s syndrome through inhibiting differentiation of type 1 regulatory T cells. Arthritis Rheumatol 67"},{"issue":"4","key":"8793_CR133","doi-asserted-by":"crossref","first-page":"R172","DOI":"10.1186\/ar3925","volume":"14","author":"BH Lee","year":"2012","unstructured":"Lee BH et al (2012) Gene therapy using IL-27 ameliorates Sjogren\u2019s syndrome-like autoimmune exocrinopathy. Arthritis Res Ther 14(4):R172","journal-title":"Arthritis Res Ther"},{"issue":"7","key":"8793_CR134","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1177\/0022034516634647","volume":"95","author":"LW Zhang","year":"2016","unstructured":"Zhang LW et al (2016) Interleukin-17 impairs salivary tight junction integrity in Sjogren\u2019s syndrome. J Dent Res 95(7):784\u2013792","journal-title":"J Dent Res"},{"issue":"6","key":"8793_CR135","doi-asserted-by":"crossref","first-page":"R220","DOI":"10.1186\/ar3207","volume":"12","author":"CQ Nguyen","year":"2010","unstructured":"Nguyen CQ et al (2010) Pathogenic effect of interleukin-17A in induction of Sjogren\u2019s syndrome-like disease using adenovirus-mediated gene transfer. Arthritis Res Ther 12(6):R220","journal-title":"Arthritis Res Ther"},{"key":"8793_CR136","doi-asserted-by":"crossref","unstructured":"Kong DH et al (2018) Emerging roles of vascular cell adhesion molecule-1 (VCAM-1) in immunological disorders and cancer. Int J Mol Sci 19(4)","DOI":"10.3390\/ijms19041057"},{"issue":"1","key":"8793_CR137","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.yexcr.2017.06.003","volume":"358","author":"C Cerutti","year":"2017","unstructured":"Cerutti C, Ridley AJ (2017) Endothelial cell-cell adhesion and signaling. Exp Cell Res 358(1):31\u201338","journal-title":"Exp Cell Res"},{"issue":"10","key":"8793_CR138","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1111\/jcmm.12102","volume":"17","author":"JH Lee","year":"2013","unstructured":"Lee JH et al (2013) A novel human anti-VCAM-1 monoclonal antibody ameliorates airway inflammation and remodelling. J Cell Mol Med 17(10):1271\u20131281","journal-title":"J Cell Mol Med"},{"issue":"5","key":"8793_CR139","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1182\/blood-2005-12-012781","volume":"108","author":"JP Abonia","year":"2006","unstructured":"Abonia JP et al (2006) Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung. Blood 108(5):1588\u20131594","journal-title":"Blood"},{"key":"8793_CR140","doi-asserted-by":"crossref","first-page":"795","DOI":"10.3389\/fimmu.2019.00795","volume":"10","author":"Z Liu","year":"2019","unstructured":"Liu Z et al (2019) Elevated CCL19\/CCR7 expression during the disease process of primary Sjogren\u2019s syndrome. Front Immunol 10:795","journal-title":"Front Immunol"},{"issue":"2","key":"8793_CR141","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/eji.201646722","volume":"47","author":"S Woyciechowski","year":"2017","unstructured":"Woyciechowski S, Hofmann M, Pircher H (2017) alpha4 beta1 integrin promotes accumulation of tissue-resident memory CD8(+) T cells in salivary glands. Eur J Immunol 47(2):244\u2013250","journal-title":"Eur J Immunol"},{"issue":"1","key":"8793_CR142","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4049\/jimmunol.1401118","volume":"194","author":"M Iizuka","year":"2015","unstructured":"Iizuka M et al (2015) A crucial role of RORgammat in the development of spontaneous Sialadenitis-like Sjogren\u2019s syndrome. J Immunol 194(1):56\u201367","journal-title":"J Immunol"},{"key":"8793_CR143","doi-asserted-by":"crossref","unstructured":"Blokland SLM et al (2017) Decreased circulating CXCR3+CCR9+Th cells coincides with elevated levels of their ligands CXCL10 and CCL25 in the salivary gland of Sjogren\u2019s syndrome patients which synergistically facilitate Th cell migration. Arthritis & Rheumatology 69","DOI":"10.1136\/annrheumdis-2017-eular.2830"},{"issue":"7086","key":"8793_CR144","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1038\/nature04651","volume":"440","author":"F Castellino","year":"2006","unstructured":"Castellino F et al (2006) Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature 440(7086):890\u2013895","journal-title":"Nature"},{"issue":"5","key":"8793_CR145","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1189\/jlb.1107794","volume":"83","author":"ME Wildenberg","year":"2008","unstructured":"Wildenberg ME et al (2008) Lack of CCR5 on dendritic cells promotes a proinflammatory environment in submandibular glands of the NOD mouse. J Leukoc Biol 83(5):1194\u20131200","journal-title":"J Leukoc Biol"},{"issue":"9","key":"8793_CR146","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1093\/rheumatology\/kep149","volume":"48","author":"TR Reksten","year":"2009","unstructured":"Reksten TR et al (2009) Cytokine and autoantibody profiling related to histopathological features in primary Sjogren\u2019s syndrome. Rheumatology (Oxford) 48(9):1102\u20131106","journal-title":"Rheumatology (Oxford)"},{"issue":"5","key":"8793_CR147","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1002\/art.21006","volume":"52","author":"TO Hjelmervik","year":"2005","unstructured":"Hjelmervik TO et al (2005) Gene expression profiling of minor salivary glands clearly distinguishes primary Sjogren\u2019s syndrome patients from healthy control subjects. Arthritis Rheum 52(5):1534\u20131544","journal-title":"Arthritis Rheum"},{"issue":"7","key":"8793_CR148","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1093\/rheumatology\/ker019","volume":"50","author":"G Hernandez-Molina","year":"2011","unstructured":"Hernandez-Molina G et al (2011) Chemokine saliva levels in patients with primary Sjogren\u2019s syndrome, associated Sjogren\u2019s syndrome, pre-clinical Sjogren\u2019s syndrome and systemic autoimmune diseases. Rheumatology (Oxford) 50(7):1288\u20131292","journal-title":"Rheumatology (Oxford)"},{"issue":"2","key":"8793_CR149","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/1529-0131(200102)44:2<408::AID-ANR60>3.0.CO;2-0","volume":"44","author":"G Xanthou","year":"2001","unstructured":"Xanthou G et al (2001) \u201cLymphoid\u201d chemokine messenger RNA expression by epithelial cells in the chronic inflammatory lesion of the salivary glands of Sjogren\u2019s syndrome patients: possible participation in lymphoid structure formation. Arthritis Rheum 44(2):408\u2013418","journal-title":"Arthritis Rheum"},{"issue":"5","key":"8793_CR150","first-page":"777","volume":"35","author":"M Tandon","year":"2017","unstructured":"Tandon M et al (2017) Laser microdissection coupled with RNA-seq reveal cell-type and disease-specific markers in the salivary gland of Sjogren\u2019s syndrome patients. Clin Exp Rheumatol 35(5):777\u2013785","journal-title":"Clin Exp Rheumatol"},{"issue":"10","key":"8793_CR151","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1002\/art.10577","volume":"46","author":"N Ogawa","year":"2002","unstructured":"Ogawa N et al (2002) Involvement of the interferon-gamma-induced T cell-attracting chemokines, interferon-gamma-inducible 10-kd protein (CXCL10) and monokine induced by interferon-gamma (CXCL9), in the salivary gland lesions of patients with Sjogren\u2019s syndrome. Arthritis Rheum 46(10):2730\u20132741","journal-title":"Arthritis Rheum"},{"issue":"3","key":"8793_CR152","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.clim.2004.03.008","volume":"112","author":"N Ogawa","year":"2004","unstructured":"Ogawa N et al (2004) Expression of interferon-inducible T cell alpha chemoattractant (CXCL11) in the salivary glands of patients with Sjogren\u2019s syndrome. Clin Immunol 112(3):235\u2013238","journal-title":"Clin Immunol"},{"issue":"6","key":"8793_CR153","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1002\/art.21062","volume":"52","author":"F Barone","year":"2005","unstructured":"Barone F et al (2005) Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjogren\u2019s syndrome. Arthritis Rheum 52(6):1773\u20131784","journal-title":"Arthritis Rheum"},{"issue":"11","key":"8793_CR154","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1002\/art.11311","volume":"48","author":"S Salomonsson","year":"2003","unstructured":"Salomonsson S et al (2003) Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjogren\u2019s syndrome. Arthritis Rheum 48(11):3187\u20133201","journal-title":"Arthritis Rheum"},{"issue":"4","key":"8793_CR155","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1084\/jem.20131737","volume":"211","author":"H Fleige","year":"2014","unstructured":"Fleige H et al (2014) IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J Exp Med 211(4):643\u2013651","journal-title":"J Exp Med"},{"issue":"18","key":"8793_CR156","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1182\/blood-2016-08-737239","volume":"129","author":"S Pandey","year":"2017","unstructured":"Pandey S et al (2017) IL-4\/CXCL12 loop is a key regulator of lymphoid stroma function in follicular lymphoma. Blood 129(18):2507\u20132518","journal-title":"Blood"},{"issue":"7","key":"8793_CR157","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.4049\/jimmunol.180.7.5130","volume":"180","author":"F Barone","year":"2008","unstructured":"Barone F et al (2008) CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren\u2019s syndrome and MALT lymphoma: association with reactive and malignant areas of lymphoid organization. J Immunol 180(7):5130\u20135140","journal-title":"J Immunol"},{"issue":"1","key":"8793_CR158","doi-asserted-by":"crossref","first-page":"R2","DOI":"10.1186\/ar3220","volume":"13","author":"EA Szyszko","year":"2011","unstructured":"Szyszko EA et al (2011) Salivary glands of primary Sjogren\u2019s syndrome patients express factors vital for plasma cell survival. Arthritis Res Ther 13(1):R2","journal-title":"Arthritis Res Ther"},{"issue":"11","key":"8793_CR159","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1002\/1529-0131(200111)44:11<2633::AID-ART443>3.0.CO;2-9","volume":"44","author":"N Amft","year":"2001","unstructured":"Amft N et al (2001) Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjogren\u2019s syndrome. Arthritis Rheum 44(11):2633\u20132641","journal-title":"Arthritis Rheum"},{"issue":"5","key":"8793_CR160","doi-asserted-by":"crossref","first-page":"716","DOI":"10.3109\/14397595.2015.1129694","volume":"26","author":"J Zhao","year":"2016","unstructured":"Zhao J et al (2016) Association of plasmacytoid dendritic cells with B cell infiltration in minor salivary glands in patients with Sjogren\u2019s syndrome. Mod Rheumatol 26(5):716\u2013724","journal-title":"Mod Rheumatol"},{"issue":"2","key":"8793_CR161","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/84205","volume":"2","author":"SA Luther","year":"2001","unstructured":"Luther SA, Cyster JG (2001) Chemokines as regulators of T cell differentiation. Nat Immunol 2(2):102\u2013107","journal-title":"Nat Immunol"},{"issue":"8","key":"8793_CR162","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1093\/rheumatology\/keq079","volume":"49","author":"N Iwamoto","year":"2010","unstructured":"Iwamoto N et al (2010) Regulation of disease susceptibility and mononuclear cell infiltration into the labial salivary glands of Sjogren\u2019s syndrome by monocyte chemotactic protein-1. Rheumatology (Oxford) 49(8):1472\u20131478","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"8793_CR163","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1365-2249.2012.04587.x","volume":"169","author":"M Moriyama","year":"2012","unstructured":"Moriyama M et al (2012) Cytokine\/chemokine profiles contribute to understanding the pathogenesis and diagnosis of primary Sjogren\u2019s syndrome. Clin Exp Immunol 169(1):17\u201326","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"8793_CR164","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1167\/iovs.03-0812","volume":"45","author":"EK Akpek","year":"2004","unstructured":"Akpek EK et al (2004) Chemokines in autoimmune lacrimal gland disease in MRL\/MpJ mice. Invest Ophthalmol Vis Sci 45(1):185\u2013190","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"8793_CR165","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3389\/fimmu.2015.00609","volume":"6","author":"N Karin","year":"2015","unstructured":"Karin N, Wildbaum G (2015) The role of chemokines in shaping the balance between CD4(+) T cell subsets and its therapeutic implications in autoimmune and cancer diseases. Front Immunol 6:609","journal-title":"Front Immunol"},{"key":"8793_CR166","doi-asserted-by":"crossref","unstructured":"Chow MT et al (2019) Intratumoral activity of the CXCR3 chemokine system is required for the efficacy of anti-PD-1 therapy. Immunity","DOI":"10.1016\/j.immuni.2019.04.010"},{"issue":"9","key":"8793_CR167","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1093\/rheumatology\/keq121","volume":"49","author":"YJ Lee","year":"2010","unstructured":"Lee YJ et al (2010) Salivary chemokine levels in patients with primary Sjogren\u2019s syndrome. Rheumatology (Oxford) 49(9):1747\u20131752","journal-title":"Rheumatology (Oxford)"},{"issue":"2","key":"8793_CR168","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1471-4906(00)01812-3","volume":"22","author":"V Appay","year":"2001","unstructured":"Appay V, Rowland-Jones SL (2001) RANTES: a versatile and controversial chemokine. Trends Immunol 22(2):83\u201387","journal-title":"Trends Immunol"},{"issue":"7","key":"8793_CR169","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002098","volume":"7","author":"A Crawford","year":"2011","unstructured":"Crawford A et al (2011) A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection. PLoS Pathog 7(7):e1002098","journal-title":"PLoS Pathog"},{"key":"8793_CR170","doi-asserted-by":"crossref","unstructured":"Blokland SLM et al (2019) Emerging roles for chemokines and cytokines as orchestrators of immunopathology in Sj\u00f6gren\u2019s syndrome. Rheumatology","DOI":"10.1093\/rheumatology\/key438"},{"issue":"5","key":"8793_CR171","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1189\/jlb.0113036","volume":"94","author":"JM Kramer","year":"2013","unstructured":"Kramer JM, Klimatcheva E, Rothstein TL (2013) CXCL13 is elevated in Sjogren\u2019s syndrome in mice and humans and is implicated in disease pathogenesis. J Leukoc Biol 94(5):1079\u20131089","journal-title":"J Leukoc Biol"},{"issue":"Suppl 2","key":"8793_CR172","first-page":"1270","volume":"77","author":"MS Van Ginkel","year":"2018","unstructured":"Van Ginkel MS et al (2018) AB0164\u00a0numbers of b-lymphocytes increase when formation of lymphoepithelial lesions progresses in salivary glands of primary sj\u00f6gren\u2019s syndrome patients. Ann Rheum Dis 77(Suppl 2):1270\u20131271","journal-title":"Ann Rheum Dis"},{"key":"8793_CR173","doi-asserted-by":"crossref","first-page":"631787","DOI":"10.1155\/2014\/631787","volume":"2014","author":"K Szabo","year":"2014","unstructured":"Szabo K et al (2014) The histopathology of labial salivary glands in primary Sjogren\u2019s syndrome: focusing on follicular helper T cells in the inflammatory infiltrates. Mediat Inflamm 2014:631787","journal-title":"Mediat Inflamm"},{"issue":"1","key":"8793_CR174","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/icb.2013.69","volume":"92","author":"A Pratama","year":"2014","unstructured":"Pratama A, Vinuesa CG (2014) Control of TFH cell numbers: why and how? Immunol Cell Biol 92(1):40\u201348","journal-title":"Immunol Cell Biol"},{"key":"8793_CR175","doi-asserted-by":"crossref","unstructured":"Brokstad KA, et al (2018) T follicular-like helper cells in the peripheral blood of patients with primary Sjogren\u2019s syndrome. Scand J Immunol e12679","DOI":"10.1111\/sji.12679"},{"issue":"1","key":"8793_CR176","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/cei.12703","volume":"183","author":"K Szabo","year":"2016","unstructured":"Szabo K et al (2016) A comprehensive investigation on the distribution of circulating follicular T helper cells and B cell subsets in primary Sjogren\u2019s syndrome and systemic lupus erythematosus. Clin Exp Immunol 183(1):76\u201389","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"8793_CR177","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.immuni.2013.09.007","volume":"39","author":"J He","year":"2013","unstructured":"He J et al (2013) Circulating precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity 39(4):770\u2013781","journal-title":"Immunity"},{"issue":"12","key":"8793_CR178","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1002\/art.39315","volume":"67","author":"G Nocturne","year":"2015","unstructured":"Nocturne G et al (2015) CXCL13 and CCL11 serum levels and lymphoma and disease activity in primary Sjogren\u2019s syndrome. Arthritis Rheumatol 67(12):3226\u20133233","journal-title":"Arthritis Rheumatol"},{"issue":"12","key":"8793_CR179","doi-asserted-by":"crossref","first-page":"5761","DOI":"10.4049\/jimmunol.1300749","volume":"192","author":"A Granato","year":"2014","unstructured":"Granato A et al (2014) IL-4 regulates Bim expression and promotes B cell maturation in synergy with BAFF conferring resistance to cell death at negative selection checkpoints. J Immunol 192(12):5761\u20135775","journal-title":"J Immunol"},{"issue":"30","key":"8793_CR180","doi-asserted-by":"crossref","first-page":"27169","DOI":"10.1074\/jbc.M201207200","volume":"277","author":"AL Wurster","year":"2002","unstructured":"Wurster AL et al (2002) Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL. J Biol Chem 277(30):27169\u201327175","journal-title":"J Biol Chem"},{"issue":"9","key":"8793_CR181","doi-asserted-by":"crossref","first-page":"4818","DOI":"10.4049\/jimmunol.170.9.4818","volume":"170","author":"RR Singh","year":"2003","unstructured":"Singh RR et al (2003) Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis. J Immunol 170(9):4818\u20134825","journal-title":"J Immunol"},{"issue":"1","key":"8793_CR182","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4049\/jimmunol.179.1.382","volume":"179","author":"CQ Nguyen","year":"2007","unstructured":"Nguyen CQ et al (2007) IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjogren\u2019s syndrome-like disease of the nonobese diabetic mouse. J Immunol 179(1):382\u2013390","journal-title":"J Immunol"},{"issue":"48","key":"8793_CR183","doi-asserted-by":"crossref","first-page":"34605","DOI":"10.1074\/jbc.M705100200","volume":"282","author":"L Wei","year":"2007","unstructured":"Wei L et al (2007) IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem 282(48):34605\u201334610","journal-title":"J Biol Chem"},{"issue":"7","key":"8793_CR184","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/sj.icb.7100114","volume":"85","author":"EK Deenick","year":"2007","unstructured":"Deenick EK, Tangye SG (2007) Autoimmunity: IL-21: a new player in Th17-cell differentiation. Immunol Cell Biol 85(7):503\u2013505","journal-title":"Immunol Cell Biol"},{"issue":"6","key":"8793_CR185","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1136\/annrheumdis-2013-204584","volume":"74","author":"X Lin","year":"2015","unstructured":"Lin X et al (2015) Th17 cells play a critical role in the development of experimental Sjogren\u2019s syndrome. Ann Rheum Dis 74(6):1302\u20131310","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"8793_CR186","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1136\/annrheumdis-2012-202754","volume":"72","author":"F Ciccia","year":"2013","unstructured":"Ciccia F et al (2013) Rituximab modulates the expression of IL-22 in the salivary glands of patients with primary Sjogren\u2019s syndrome. Ann Rheum Dis 72(5):782\u2013783","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"8793_CR187","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1038\/leu.2008.129","volume":"22","author":"JD Bard","year":"2008","unstructured":"Bard JD et al (2008) Aberrant expression of IL-22 receptor 1 and autocrine IL-22 stimulation contribute to tumorigenicity in ALK+ anaplastic large cell lymphoma. Leukemia 22(8):1595\u20131603","journal-title":"Leukemia"},{"issue":"2","key":"8793_CR188","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/cei.12643","volume":"181","author":"F Ciccia","year":"2015","unstructured":"Ciccia F et al (2015) Interleukin (IL)-22 receptor 1 is over-expressed in primary Sjogren\u2019s syndrome and Sjogren-associated non-Hodgkin lymphomas and is regulated by IL-18. Clin Exp Immunol 181(2):219\u2013229","journal-title":"Clin Exp Immunol"},{"issue":"5","key":"8793_CR189","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1084\/jem.20151722","volume":"213","author":"PP Domeier","year":"2016","unstructured":"Domeier PP et al (2016) IFN-gamma receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity. J Exp Med 213(5):715\u2013732","journal-title":"J Exp Med"},{"issue":"40","key":"8793_CR190","doi-asserted-by":"crossref","first-page":"17292","DOI":"10.1073\/pnas.1004879107","volume":"107","author":"E Mohr","year":"2010","unstructured":"Mohr E et al (2010) IFN-{gamma} produced by CD8 T cells induces T-bet-dependent and -independent class switching in B cells in responses to alum-precipitated protein vaccine. Proc Natl Acad Sci U S A 107(40):17292\u201317297","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8793_CR191","doi-asserted-by":"crossref","unstructured":"Matsui K, Sano H (2017) T helper 17 cells in primary Sjogren\u2019s syndrome. J Clin Med 6(7)","DOI":"10.3390\/jcm6070065"},{"key":"8793_CR192","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev-immunol-042617-053352","volume":"36","author":"SH Ross","year":"2018","unstructured":"Ross SH, Cantrell DA (2018) Signaling and function of interleukin-2 in T lymphocytes. Annu Rev Immunol 36:411\u2013433","journal-title":"Annu Rev Immunol"},{"issue":"9","key":"8793_CR193","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/d00094ef-aac0-43ce-bba6-50d5a1cdbb37","volume":"7","author":"J Zhao","year":"2012","unstructured":"Zhao J, Zhao J, Perlman S (2012) Differential effects of IL-12 on Tregs and non-Treg T cells: roles of IFN-gamma, IL-2 and IL-2R. PLoS One 7(9):e46241","journal-title":"PLoS One"},{"issue":"6","key":"8793_CR194","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.smim.2011.08.003","volume":"23","author":"C Pot","year":"2011","unstructured":"Pot C et al (2011) Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27. Semin Immunol 23(6):438\u2013445","journal-title":"Semin Immunol"},{"issue":"2","key":"8793_CR195","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.immuni.2017.01.009","volume":"46","author":"S Cheuk","year":"2017","unstructured":"Cheuk S et al (2017) CD49a expression defines tissue-resident CD8(+) T cells poised for cytotoxic function in human skin. Immunity 46(2):287\u2013300","journal-title":"Immunity"},{"issue":"4","key":"8793_CR196","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.4049\/jimmunol.163.4.2226","volume":"163","author":"T Fujihara","year":"1999","unstructured":"Fujihara T et al (1999) Preferential localization of CD8+ alpha E beta 7+ T cells around acinar epithelial cells with apoptosis in patients with Sjogren\u2019s syndrome. J Immunol 163(4):2226\u20132235","journal-title":"J Immunol"},{"issue":"4","key":"8793_CR197","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.immuni.2014.09.013","volume":"41","author":"IS Schuster","year":"2014","unstructured":"Schuster IS et al (2014) TRAIL+ NK cells control CD4+ T cell responses during chronic viral infection to limit autoimmunity. Immunity 41(4):646\u2013656","journal-title":"Immunity"},{"issue":"9","key":"8793_CR198","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1002\/art.21265","volume":"52","author":"P Perez","year":"2005","unstructured":"Perez P et al (2005) Increased acinar damage of salivary glands of patients with Sjogren\u2019s syndrome is paralleled by simultaneous imbalance of matrix metalloproteinase 3\/tissue inhibitor of metalloproteinases 1 and matrix metalloproteinase 9\/tissue inhibitor of metalloproteinases 1 ratios. Arthritis Rheum 52(9):2751\u20132760","journal-title":"Arthritis Rheum"},{"issue":"6","key":"8793_CR199","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.4049\/jimmunol.1301360","volume":"191","author":"LK Fogli","year":"2013","unstructured":"Fogli LK et al (2013) T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia. J Immunol 191(6):3100\u20133111","journal-title":"J Immunol"},{"issue":"5","key":"8793_CR200","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1182\/blood-2008-05-078154","volume":"112","author":"J Zhu","year":"2008","unstructured":"Zhu J, Paul WE (2008) CD4 T cells: fates, functions, and faults. Blood 112(5):1557\u20131569","journal-title":"Blood"},{"issue":"7090","key":"8793_CR201","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature04754","volume":"441","author":"PR Mangan","year":"2006","unstructured":"Mangan PR et al (2006) Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441(7090):231\u2013234","journal-title":"Nature"},{"issue":"6","key":"8793_CR202","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2217\/imt-2018-0095","volume":"11","author":"SH Kim","year":"2019","unstructured":"Kim SH et al (2019) Delayed IL-21 treatment preferentially expands peptide-specific CD8(+) T cells by reducing bystander activation of T cells. Immunotherapy 11(6):497\u2013513","journal-title":"Immunotherapy"},{"key":"8793_CR203","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.gdata.2015.11.014","volume":"7","author":"TN Lavoie","year":"2016","unstructured":"Lavoie TN et al (2016) IL-22 regulation of functional gene expression in salivary gland cells. Genom Data 7:178\u2013184","journal-title":"Genom Data"},{"issue":"8","key":"8793_CR204","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1601-0825.2009.01582.x","volume":"15","author":"N Roescher","year":"2009","unstructured":"Roescher N, Tak PP, Illei GG (2009) Cytokines in Sjogren\u2019s syndrome. Oral Dis 15(8):519\u2013526","journal-title":"Oral Dis"},{"issue":"1","key":"8793_CR205","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1385\/CRIAI:25:1:89","volume":"25","author":"AT Borchers","year":"2003","unstructured":"Borchers AT et al (2003) Immunopathogenesis of Sjogren\u2019s syndrome. Clin Rev Allergy Immunol 25(1):89\u2013104","journal-title":"Clin Rev Allergy Immunol"},{"issue":"1","key":"8793_CR206","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/art.1780400113","volume":"40","author":"L Kong","year":"1997","unstructured":"Kong L et al (1997) Fas and Fas ligand expression in the salivary glands of patients with primary Sjogren\u2019s syndrome. Arthritis Rheum 40(1):87\u201397","journal-title":"Arthritis Rheum"},{"issue":"6","key":"8793_CR207","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.0300-9475.2004.01508.x","volume":"60","author":"S Cha","year":"2004","unstructured":"Cha S et al (2004) A dual role for interferon-gamma in the pathogenesis of Sjogren\u2019s syndrome-like autoimmune exocrinopathy in the nonobese diabetic mouse. Scand J Immunol 60(6):552\u2013565","journal-title":"Scand J Immunol"},{"issue":"11","key":"8793_CR208","doi-asserted-by":"crossref","first-page":"6637","DOI":"10.4049\/jimmunol.167.11.6637","volume":"167","author":"AY Savinov","year":"2001","unstructured":"Savinov AY, Wong FS, Chervonsky AV (2001) IFN-gamma affects homing of diabetogenic T cells. J Immunol 167(11):6637\u20136643","journal-title":"J Immunol"},{"issue":"3","key":"8793_CR209","volume":"6","author":"H Yin","year":"2011","unstructured":"Yin H et al (2011) Location of immunization and interferon-gamma are central to induction of salivary gland dysfunction in Ro60 peptide immunized model of Sjogren\u2019s syndrome. PLoS One 6(3):e18003","journal-title":"PLoS One"},{"issue":"3","key":"8793_CR210","first-page":"435","volume":"32","author":"PH Dessein","year":"2005","unstructured":"Dessein PH et al (2005) Traditional and nontraditional cardiovascular risk factors are associated with atherosclerosis in rheumatoid arthritis. J Rheumatol 32(3):435\u2013442","journal-title":"J Rheumatol"},{"issue":"3","key":"8793_CR211","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/acr.21841","volume":"65","author":"CC Mok","year":"2013","unstructured":"Mok CC et al (2013) High-sensitivity C-reactive protein, disease activity, and cardiovascular risk factors in systemic lupus erythematosus. Arthritis Care & Research 65(3):441\u2013447","journal-title":"Arthritis Care & Research"},{"issue":"4","key":"8793_CR212","first-page":"754","volume":"34","author":"M Ramos-Casals","year":"2007","unstructured":"Ramos-Casals M et al (2007) High prevalence of serum metabolic alterations in primary Sjogren\u2019s syndrome: influence on clinical and immunological expression. J Rheumatol 34(4):754\u2013761","journal-title":"J Rheumatol"},{"issue":"3","key":"8793_CR213","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s10067-015-3072-1","volume":"35","author":"KL Augusto","year":"2016","unstructured":"Augusto KL et al (2016) Metabolic syndrome in Sjogren\u2019s syndrome patients: a relevant concern for clinical monitoring. Clin Rheumatol 35(3):639\u2013647","journal-title":"Clin Rheumatol"},{"issue":"3","key":"8793_CR214","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/08916934.2018.1446525","volume":"51","author":"LA Aqrawi","year":"2018","unstructured":"Aqrawi LA et al (2018) Signalling pathways identified in salivary glands from primary Sjogren\u2019s syndrome patients reveal enhanced adipose tissue development. Autoimmunity 51(3):135\u2013146","journal-title":"Autoimmunity"},{"issue":"5","key":"8793_CR215","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.cmet.2016.04.011","volume":"23","author":"JH Stern","year":"2016","unstructured":"Stern JH, Rutkowski JM, Scherer PE (2016) Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk. Cell Metab 23(5):770\u2013784","journal-title":"Cell Metab"},{"issue":"1","key":"8793_CR216","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1172\/JCI88876","volume":"127","author":"T McLaughlin","year":"2017","unstructured":"McLaughlin T et al (2017) Role of innate and adaptive immunity in obesity-associated metabolic disease. J Clin Invest 127(1):5\u201313","journal-title":"J Clin Invest"},{"issue":"12","key":"8793_CR217","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1016\/j.celrep.2018.11.083","volume":"25","author":"J Gilleron","year":"2018","unstructured":"Gilleron J et al (2018) Rab4b deficiency in T cells promotes adipose Treg\/Th17 imbalance, adipose tissue dysfunction, and insulin resistance. Cell Rep 25(12):3329\u20133341 e5","journal-title":"Cell Rep"},{"key":"8793_CR218","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2147\/JAA.S104508","volume":"9","author":"Z Jiang","year":"2016","unstructured":"Jiang Z, Zhu L (2016) Update on the role of alternatively activated macrophages in asthma. J Asthma Allergy 9:101\u2013107","journal-title":"J Asthma Allergy"},{"issue":"1","key":"8793_CR219","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1600-065X.2012.01150.x","volume":"249","author":"GJ van der Windt","year":"2012","unstructured":"van der Windt GJ, Pearce EL (2012) Metabolic switching and fuel choice during T-cell differentiation and memory development. Immunol Rev 249(1):27\u201342","journal-title":"Immunol Rev"},{"issue":"4","key":"8793_CR220","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.cell.2015.03.021","volume":"161","author":"G Cui","year":"2015","unstructured":"Cui G et al (2015) IL-7-induced glycerol transport and TAG synthesis promotes memory CD8+ T cell longevity. Cell 161(4):750\u2013761","journal-title":"Cell"},{"issue":"7644","key":"8793_CR221","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nature21379","volume":"543","author":"Y Pan","year":"2017","unstructured":"Pan Y et al (2017) Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature 543(7644):252\u2013256","journal-title":"Nature"},{"issue":"11","key":"8793_CR222","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1158\/2326-6066.CIR-18-0095","volume":"6","author":"PS Chowdhury","year":"2018","unstructured":"Chowdhury PS et al (2018) PPAR-induced fatty acid oxidation in T cells increases the number of tumor-reactive CD8(+) T cells and facilitates anti-PD-1 therapy. Cancer Immunol Res 6(11):1375\u20131387","journal-title":"Cancer Immunol Res"},{"issue":"4","key":"8793_CR223","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.hfc.2012.06.012","volume":"8","author":"JA Kim","year":"2012","unstructured":"Kim JA et al (2012) Role of lipotoxicity in endothelial dysfunction. Heart Fail Clin 8(4):589\u2013607","journal-title":"Heart Fail Clin"},{"issue":"4","key":"8793_CR224","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1001\/jama.2010.1014","volume":"304","author":"M Ramos-Casals","year":"2010","unstructured":"Ramos-Casals M et al (2010) Treatment of primary Sjogren syndrome: a systematic review. JAMA 304(4):452\u2013460","journal-title":"JAMA"},{"issue":"10","key":"8793_CR225","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1056\/NEJMcp1702514","volume":"378","author":"X Mariette","year":"2018","unstructured":"Mariette X, Criswell LA (2018) Primary Sjogren\u2019s syndrome. N Engl J Med 378(10):931\u2013939","journal-title":"N Engl J Med"},{"key":"8793_CR226","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12986-016-0123-9","volume":"13","author":"SK Wong","year":"2016","unstructured":"Wong SK et al (2016) Animal models of metabolic syndrome: a review. Nutr Metab (Lond) 13:65","journal-title":"Nutr Metab (Lond)"},{"key":"8793_CR227","doi-asserted-by":"crossref","first-page":"102333","DOI":"10.1016\/j.jaut.2019.102333","volume":"104","author":"C Huang","year":"2019","unstructured":"Huang C et al (2019) Immune checkpoint molecules. Possible future therapeutic implications in autoimmune diseases. J Autoimmun 104:102333","journal-title":"J Autoimmun"},{"issue":"7","key":"8793_CR228","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrrheum.2012.53","volume":"8","author":"M Ramos-Casals","year":"2012","unstructured":"Ramos-Casals M et al (2012) Topical and systemic medications for the treatment of primary Sjogren\u2019s syndrome. Nat Rev Rheumatol 8(7):399\u2013411","journal-title":"Nat Rev Rheumatol"},{"issue":"3","key":"8793_CR229","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/annrheumdis-2013-203991","volume":"74","author":"X Mariette","year":"2015","unstructured":"Mariette X et al (2015) Efficacy and safety of belimumab in primary Sjogren\u2019s syndrome: results of the BELISS open-label phase II study. Ann Rheum Dis 74(3):526\u2013531","journal-title":"Ann Rheum Dis"},{"key":"8793_CR230","doi-asserted-by":"crossref","unstructured":"Baer AN (2020) Oasis or mirage\u2014a new drug shows promise for Sj\u00f6gren's syndrome. Lancet Rheumatol","DOI":"10.1016\/S2665-9913(19)30143-2"},{"key":"8793_CR231","unstructured":"Fisher BA, et al Assessment of the anti-CD40 antibody iscalimab in patients with primary Sj\u00f6gren\u2019s syndrome: a multicentre, randomised, double-blind, placebo-controlled, proof-of-concept study. Lancet Rheumatol"},{"issue":"11","key":"8793_CR232","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1002\/acr.22052","volume":"65","author":"S Adler","year":"2013","unstructured":"Adler S et al (2013) Evaluation of histologic, serologic, and clinical changes in response to abatacept treatment of primary Sjogren\u2019s syndrome: a pilot study. Arthritis Care Res (Hoboken) 65(11):1862\u20131868","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"8793_CR233","unstructured":"van Nimwegen JF, et al Abatacept treatment for patients with early active primary Sj\u00f6gren\u2019s syndrome: a single-centre, randomised, double-blind, placebo-controlled, phase 3 trial (ASAP-III study). Lancet Rheumatol"},{"issue":"9","key":"8793_CR234","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1002\/art.40165","volume":"69","author":"GM Verstappen","year":"2017","unstructured":"Verstappen GM et al (2017) Attenuation of follicular helper T cell-dependent B cell hyperactivity by abatacept treatment in primary Sjogren\u2019s syndrome. Arthritis Rheumatol 69(9):1850\u20131861","journal-title":"Arthritis Rheumatol"},{"issue":"7","key":"8793_CR235","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1136\/annrheumdis-2013-204653","volume":"73","author":"PM Meiners","year":"2014","unstructured":"Meiners PM et al (2014) Abatacept treatment reduces disease activity in early primary Sjogren\u2019s syndrome (open-label proof of concept ASAP study). Ann Rheum Dis 73(7):1393\u20131396","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"8793_CR236","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/labinvest.3700234","volume":"85","author":"K Motegi","year":"2005","unstructured":"Motegi K et al (2005) Expression of aquaporin-5 in and fluid secretion from immortalized human salivary gland ductal cells by treatment with 5-aza-2\u2032-deoxycytidine: a possibility for improvement of xerostomia in patients with Sjogren\u2019s syndrome. Lab Investig 85(3):342\u2013353","journal-title":"Lab Investig"},{"issue":"20","key":"8793_CR237","doi-asserted-by":"crossref","first-page":"5694","DOI":"10.1073\/pnas.1601992113","volume":"113","author":"Z Lai","year":"2016","unstructured":"Lai Z et al (2016) Aquaporin gene therapy corrects Sjogren\u2019s syndrome phenotype in mice. Proc Natl Acad Sci U S A 113(20):5694\u20135699","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"8793_CR238","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1053\/j.gastro.2017.06.011","volume":"153","author":"M Zeng","year":"2017","unstructured":"Zeng M et al (2017) Restoration of CFTR activity in ducts rescues acinar cell function and reduces inflammation in pancreatic and salivary glands of mice. Gastroenterology 153(4):1148\u20131159","journal-title":"Gastroenterology"}],"container-title":["Clinical Reviews in Allergy &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-020-08793-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12016-020-08793-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-020-08793-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T17:40:28Z","timestamp":1696095628000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12016-020-08793-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,11]]},"references-count":238,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["8793"],"URL":"https:\/\/doi.org\/10.1007\/s12016-020-08793-7","relation":{},"ISSN":["1080-0549","1559-0267"],"issn-type":[{"value":"1080-0549","type":"print"},{"value":"1559-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,11]]},"assertion":[{"value":"11 May 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}