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In some airway diseases, IgE is produced as a result of allergic sensitization. However, in others, IgE production occurs despite the lack of a specific allergen. Although multiple pathways contribute to the production of IgE in airway disease, it is its activity in mediating the inflammatory response that is associated with disease. Therefore, an understanding of IgE as the unifying component of upper and lower airway diseases has important implications for both diagnosis and treatment. Understanding the role of IgE in each upper and lower airway disease highlights its potential utility as a diagnostic marker and therapeutic target. Further classification of these diseases by whether they are IgE\u00a0mediated or non\u2013IgE\u00a0mediated, rather than by the existence of an underlying allergic component, accounts for both systemic and localized IgE activity. Improvements in diagnostic methodologies and standardization of clinical practices with this classification in mind can help identify patients with IgE-mediated diseases. In doing so, this group of patients can receive optimal care through targeted anti-IgE therapeutics, which have already demonstrated efficacy across numerous IgE-mediated upper and lower airway diseases.<\/jats:p>","DOI":"10.1007\/s12016-021-08901-1","type":"journal-article","created":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T10:03:30Z","timestamp":1631959410000},"page":"200-215","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["The Role of IgE in Upper and Lower Airway Disease: More Than Just Allergy!"],"prefix":"10.1007","volume":"62","author":[{"given":"Philippe","family":"Gevaert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kit","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A.","family":"Millette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara F.","family":"Carr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,18]]},"reference":[{"issue":"4","key":"8901_CR1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.4168\/aair.2015.7.4.321","volume":"7","author":"E De Schryver","year":"2015","unstructured":"De Schryver E, Devuyst L, Derycke L et al (2015) Local immunoglobulin E in the nasal mucosa: clinical implications. 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Kit Wong is an employee of Genentech, Inc. Lauren A. Millette is an employee of Genentech, Inc. Tara F. Carr has received consulting fees from Aimmune Therapeutics, AstraZeneca, GlaxoSmithKline, Novartis, Regeneron, and Sanofi Genzyme.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}