{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:31:58Z","timestamp":1778859118397,"version":"3.51.4"},"reference-count":129,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences","award":["2020-RC320-003"],"award-info":[{"award-number":["2020-RC320-003"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972943"],"award-info":[{"award-number":["81972943"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81830097"],"award-info":[{"award-number":["81830097"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunan Talent Young Investigator","award":["2019RS2012"],"award-info":[{"award-number":["2019RS2012"]}]},{"name":"Hunan Outstanding Young Investigator","award":["2020JJ2055"],"award-info":[{"award-number":["2020JJ2055"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2019-I2M-5-033"],"award-info":[{"award-number":["2019-I2M-5-033"]}]},{"name":"Chongqing International Institute for Immunology","award":["2020YJC10"],"award-info":[{"award-number":["2020YJC10"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clinic Rev Allerg Immunol"],"DOI":"10.1007\/s12016-022-08936-y","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T07:14:31Z","timestamp":1654672471000},"page":"357-370","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Germinal Center-Related G Protein-Coupled Receptors in Antibody-Mediated Autoimmune Skin Diseases: from Basic Research to Clinical Trials"],"prefix":"10.1007","volume":"63","author":[{"given":"Pengpeng","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianjin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"issue":"6","key":"8936_CR1","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1007\/s10067-017-3652-3","volume":"36","author":"A Lee","year":"2017","unstructured":"Lee A, Bannan JL, Adams MJ et al (2017) Expression of CCR6 on B cells in systemic lupus erythematosus patients[J]. Clin Rheumatol 36(6):1453\u20131456","journal-title":"Clin Rheumatol"},{"issue":"2","key":"8936_CR2","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1183\/09031936.00101408","volume":"34","author":"T Demoor","year":"2009","unstructured":"Demoor T, Bracke KR, Maes T et al (2009) Role of lymphotoxin-alpha in cigarette smoke-induced inflammation and lymphoid neogenesis[J]. Eur Respir J 34(2):405\u2013416","journal-title":"Eur Respir J"},{"issue":"3","key":"8936_CR3","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1309\/AJCP1TA3FLOQTMHF","volume":"133","author":"MW Anderson","year":"2010","unstructured":"Anderson MW, Zhao S, Ai WZ et al (2010) C-C chemokine receptor 1 expression in human hematolymphoid neoplasia[J]. Am J Clin Pathol 133(3):473\u2013483","journal-title":"Am J Clin Pathol"},{"issue":"1\u20132","key":"8936_CR4","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.cell.2017.11.033","volume":"172","author":"AS Hauser","year":"2018","unstructured":"Hauser AS, Chavali S, Masuho I et al (2018) Pharmacogenomics of GPCR Drug Targets[J]. Cell 172(1\u20132):41\u201354","journal-title":"Cell"},{"issue":"D1","key":"8936_CR5","doi-asserted-by":"publisher","first-page":"D985","DOI":"10.1093\/nar\/gkw1055","volume":"45","author":"G Koscielny","year":"2017","unstructured":"Koscielny G, An P, Carvalho-Silva D et al (2017) Open Targets: a platform for therapeutic target identification and validation[J]. Nucleic Acids Res 45(D1):D985\u2013D994","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"8936_CR6","doi-asserted-by":"publisher","first-page":"5224","DOI":"10.1038\/s41467-018-07598-9","volume":"9","author":"O Cabral-Marques","year":"2018","unstructured":"Cabral-Marques O, Marques A, Giil LM et al (2018) GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis[J]. Nat Commun 9(1):5224","journal-title":"Nat Commun"},{"key":"8936_CR7","doi-asserted-by":"crossref","unstructured":"Groves A, Kihara Y, Jonnalagadda D et al (2018) A functionally defined in vivo astrocyte population identified by c-Fos activation in a mouse model of multiple sclerosis modulated by S1P signaling: immediate-early astrocytes (ieAstrocytes)[J]. eNeuro 5(5)","DOI":"10.1523\/ENEURO.0239-18.2018"},{"issue":"2","key":"8936_CR8","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.cmet.2019.05.022","volume":"30","author":"E Li","year":"2019","unstructured":"Li E, Shan H, Chen L et al (2019) OLFR734 Mediates glucose metabolism as a receptor of asprosin[J]. Cell Metab 30(2):319\u2013328","journal-title":"Cell Metab"},{"key":"8936_CR9","doi-asserted-by":"crossref","unstructured":"Sharma G, Hu C, Staquicini DI et al (2020) Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes[J]. Sci Transl Med 12(528)","DOI":"10.1126\/scitranslmed.aau5956"},{"issue":"9\u201310","key":"8936_CR10","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1007\/s00213-017-4545-5","volume":"234","author":"JM Palacios","year":"2017","unstructured":"Palacios JM, Pazos A, Hoyer D (2017) A short history of the 5-HT(2C) receptor: from the choroid plexus to depression, obesity and addiction treatment[J]. Psychopharmacology 234(9\u201310):1395\u20131418","journal-title":"Psychopharmacology"},{"issue":"5","key":"8936_CR11","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1021\/acsomega.9b03430","volume":"5","author":"T Yempala","year":"2020","unstructured":"Yempala T, Brea J, Loza MI et al (2020) Dibenzofuranylethylamines as 5-HT(2A\/2C) receptor agonists[J]. ACS Omega 5(5):2260\u20132266","journal-title":"ACS Omega"},{"issue":"3","key":"8936_CR12","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/s42255-020-0175-z","volume":"2","author":"W Chang","year":"2020","unstructured":"Chang W, Tu CL, Jean-Alphonse FG et al (2020) PTH hypersecretion triggered by a GABA(B1) and Ca(2+)-sensing receptor heterocomplex in hyperparathyroidism[J]. Nat Metab 2(3):243\u2013255","journal-title":"Nat Metab"},{"issue":"1","key":"8936_CR13","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1021\/acsmedchemlett.8b00622","volume":"10","author":"AF Abdel-Magid","year":"2019","unstructured":"Abdel-Magid AF (2019) Treatment of diabetes, obesity, dyslipidemia, and related disorders with GPR119 agonists[J]. ACS Med Chem Lett 10(1):14\u201315","journal-title":"ACS Med Chem Lett"},{"key":"8936_CR14","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.neuropharm.2017.08.017","volume":"125","author":"M Celorrio","year":"2017","unstructured":"Celorrio M, Rojo-Bustamante E, Fern\u00e1ndez-Su\u00e1rez D et al (2017) GPR55: a therapeutic target for Parkinson\u2019s disease?[J]. Neuropharmacology 125:319\u2013332","journal-title":"Neuropharmacology"},{"issue":"11","key":"8936_CR15","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1093\/ecco-jcc\/jjx091","volume":"11","author":"N Planell","year":"2017","unstructured":"Planell N, Masamunt MC, Leal RF et al (2017) Usefulness of transcriptional blood biomarkers as a non-invasive surrogate marker of mucosal healing and endoscopic response in ulcerative colitis[J]. J Crohns Colitis 11(11):1335\u20131346","journal-title":"J Crohns Colitis"},{"key":"8936_CR16","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1146\/annurev-immunol-032713-120145","volume":"32","author":"JW Griffith","year":"2014","unstructured":"Griffith JW, Sokol CL, Luster AD (2014) Chemokines and chemokine receptors: positioning cells for host defense and immunity[J]. Annu Rev Immunol 32:659\u2013702","journal-title":"Annu Rev Immunol"},{"key":"8936_CR17","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1146\/annurev-immunol-041015-055649","volume":"34","author":"O Schulz","year":"2016","unstructured":"Schulz O, Hammerschmidt SI, Moschovakis GL et al (2016) Chemokines and chemokine receptors in lymphoid tissue dynamics[J]. Annu Rev Immunol 34:203\u2013242","journal-title":"Annu Rev Immunol"},{"issue":"5","key":"8936_CR18","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1002\/hep.29477","volume":"67","author":"SL Friedman","year":"2018","unstructured":"Friedman SL, Ratziu V, Harrison SA et al (2018) A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis[J]. Hepatology 67(5):1754\u20131767","journal-title":"Hepatology"},{"issue":"6","key":"8936_CR19","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1056\/NEJMoa1704827","volume":"378","author":"T Sato","year":"2018","unstructured":"Sato T, Coler-Reilly A, Yagishita N et al (2018) Mogamulizumab (anti-CCR4) in HTLV-1-associated myelopathy[J]. N Engl J Med 378(6):529\u2013538","journal-title":"N Engl J Med"},{"issue":"9","key":"8936_CR20","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/S1470-2045(18)30379-6","volume":"19","author":"YH Kim","year":"2018","unstructured":"Kim YH, Bagot M, Pinter-Brown L et al (2018) Mogamulizumab versus vorinostat in previously treated cutaneous T-cell lymphoma (MAVORIC): an international, open-label, randomised, controlled phase 3 trial[J]. Lancet Oncol 19(9):1192\u20131204","journal-title":"Lancet Oncol"},{"issue":"18","key":"8936_CR21","doi-asserted-by":"publisher","first-page":"5358","DOI":"10.1158\/1078-0432.CCR-16-2748","volume":"23","author":"AF Schott","year":"2017","unstructured":"Schott AF, Goldstein LJ, Cristofanilli M et al (2017) Phase Ib Pilot study to evaluate reparixin in combination with weekly paclitaxel in patients with HER-2-negative metastatic breast cancer[J]. Clin Cancer Res 23(18):5358\u20135365","journal-title":"Clin Cancer Res"},{"issue":"6","key":"8936_CR22","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1002\/1521-4141(200206)32:6<1792::AID-IMMU1792>3.0.CO;2-0","volume":"32","author":"C Nakajima","year":"2002","unstructured":"Nakajima C, Mukai T, Yamaguchi N et al (2002) Induction of the chemokine receptor CXCR3 on TCR-stimulated T cells: dependence on the release from persistent TCR-triggering and requirement for IFN-gamma stimulation[J]. Eur J Immunol 32(6):1792\u20131801","journal-title":"Eur J Immunol"},{"issue":"6","key":"8936_CR23","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/j.immuni.2012.08.016","volume":"37","author":"JR Groom","year":"2012","unstructured":"Groom JR, Richmond J, Murooka TT et al (2012) CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation[J]. Immunity 37(6):1091\u20131103","journal-title":"Immunity"},{"issue":"9","key":"8936_CR24","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1038\/ni0901-876","volume":"2","author":"DJ Campbell","year":"2001","unstructured":"Campbell DJ, Kim CH, Butcher EC (2001) Separable effector T cell populations specialized for B cell help or tissue inflammation[J]. Nat Immunol 2(9):876\u2013881","journal-title":"Nat Immunol"},{"issue":"2","key":"8936_CR25","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.immuni.2018.06.012","volume":"49","author":"J Shi","year":"2018","unstructured":"Shi J, Hou S, Fang Q et al (2018) PD-1 Controls follicular T helper cell positioning and function[J]. Immunity 49(2):264\u2013274","journal-title":"Immunity"},{"key":"8936_CR26","doi-asserted-by":"crossref","unstructured":"Turpin D, Furudoi A, Parrens M et al (2018) Increase of follicular helper T cells skewed toward a Th1 profile in CVID patients with non-infectious clinical complications[J]. Clin Immunol 197:130\u2013138","DOI":"10.1016\/j.clim.2018.09.006"},{"issue":"1","key":"8936_CR27","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.jaci.2019.01.033","volume":"144","author":"J Bier","year":"2019","unstructured":"Bier J, Rao G, Payne K et al (2019) Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4(+) T cells[J]. J Allergy Clin Immunol 144(1):236\u2013253","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"8936_CR28","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s10875-020-00755-0","volume":"40","author":"G Ottaviano","year":"2020","unstructured":"Ottaviano G, Gerosa J, Santini M et al (2020) A prevalent CXCR3(+) phenotype of circulating follicular helper T cells indicates humoral dysregulation in children with Down Syndrome[J]. J Clin Immunol 40(3):447\u2013455","journal-title":"J Clin Immunol"},{"key":"8936_CR29","doi-asserted-by":"crossref","unstructured":"Kawaguchi N, Zhang TT, Nakanishi T (2019) Involvement of CXCR4 in normal and abnormal development[J]. Cells 8(2)","DOI":"10.3390\/cells8020185"},{"issue":"9","key":"8936_CR30","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1038\/ni1100","volume":"5","author":"CD Allen","year":"2004","unstructured":"Allen CD, Ansel KM, Low C et al (2004) Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5[J]. Nat Immunol 5(9):943\u2013952","journal-title":"Nat Immunol"},{"key":"8936_CR31","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.3389\/fimmu.2018.01313","volume":"9","author":"TS Weber","year":"2018","unstructured":"Weber TS (2018) Cell cycle-associated CXCR4 expression in germinal center B cells and its implications on affinity maturation[J]. Front Immunol 9:1313","journal-title":"Front Immunol"},{"key":"8936_CR32","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.3389\/fimmu.2018.01742","volume":"9","author":"HK Pak","year":"2018","unstructured":"Pak HK, Nam B, Lee YK et al (2018) Human plasmablast migration toward CXCL12 requires glucose oxidation by enhanced pyruvate dehydrogenase activity via AKT[J]. Front Immunol 9:1742","journal-title":"Front Immunol"},{"key":"8936_CR33","doi-asserted-by":"publisher","first-page":"14647","DOI":"10.1038\/ncomms14647","volume":"8","author":"C Jandl","year":"2017","unstructured":"Jandl C, Liu SM, Ca\u00f1ete PF et al (2017) IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2[J]. Nat Commun 8:14647","journal-title":"Nat Commun"},{"key":"8936_CR34","doi-asserted-by":"crossref","unstructured":"Unger PA, Lighaam LC, Vermeulen E et al (2020) Divergent chemokine receptor expression and the consequence for human IgG4 B\u00a0cell responses[J]. Eur J Immunol","DOI":"10.1002\/eji.201948454"},{"issue":"3","key":"8936_CR35","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.celrep.2019.12.076","volume":"30","author":"I Vanderleyden","year":"2020","unstructured":"Vanderleyden I, Fra-Bido SC, Innocentin S et al (2020) Follicular regulatory T cells can access the germinal center independently of CXCR5[J]. Cell Rep 30(3):611\u2013619","journal-title":"Cell Rep"},{"issue":"7","key":"8936_CR36","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1016\/j.celrep.2019.10.012","volume":"29","author":"E Shen","year":"2019","unstructured":"Shen E, Rabe H, Luo L et al (2019) Control of germinal center localization and lineage stability of follicular regulatory T cells by the Blimp1 transcription factor[J]. Cell Rep 29(7):1848\u20131861","journal-title":"Cell Rep"},{"issue":"3","key":"8936_CR37","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1084\/jem.20181216","volume":"216","author":"AE Denton","year":"2019","unstructured":"Denton AE, Innocentin S, Carr EJ et al (2019) Type I interferon induces CXCL13 to support ectopic germinal center formation[J]. J Exp Med 216(3):621\u2013637","journal-title":"J Exp Med"},{"issue":"1","key":"8936_CR38","doi-asserted-by":"publisher","first-page":"4415","DOI":"10.1038\/s41467-019-12446-5","volume":"10","author":"Y Chen","year":"2019","unstructured":"Chen Y, Yu M, Zheng Y et al (2019) CXCR5(+)PD-1(+) follicular helper CD8 T cells control B cell tolerance[J]. Nat Commun 10(1):4415","journal-title":"Nat Commun"},{"issue":"1","key":"8936_CR39","doi-asserted-by":"publisher","first-page":"8933","DOI":"10.1038\/s41598-017-08935-6","volume":"7","author":"GL Moschovakis","year":"2017","unstructured":"Moschovakis GL, Bubke A, Friedrichsen M et al (2017) T cell specific Cxcr5 deficiency prevents rheumatoid arthritis[J]. Sci Rep 7(1):8933","journal-title":"Sci Rep"},{"key":"8936_CR40","doi-asserted-by":"crossref","unstructured":"Gu-Trantien C, Migliori E, Buisseret L et al (2017) CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer[J]. JCI Insight 2(11)","DOI":"10.1172\/jci.insight.91487"},{"key":"8936_CR41","doi-asserted-by":"publisher","first-page":"641","DOI":"10.3389\/fphar.2018.00641","volume":"9","author":"C Wang","year":"2018","unstructured":"Wang C, Chen W, Shen J (2018) CXCR7 targeting and its major disease relevance[J]. Front Pharmacol 9:641","journal-title":"Front Pharmacol"},{"issue":"6","key":"8936_CR42","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1111\/j.1600-0609.2010.01531.x","volume":"85","author":"M Tarnowski","year":"2010","unstructured":"Tarnowski M, Liu R, Wysoczynski M et al (2010) CXCR7: a new SDF-1-binding receptor in contrast to normal CD34(+) progenitors is functional and is expressed at higher level in human malignant hematopoietic cells[J]. Eur J Haematol 85(6):472\u2013483","journal-title":"Eur J Haematol"},{"issue":"10","key":"8936_CR43","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1158\/1541-7786.MCR-10-0288","volume":"8","author":"M Tarnowski","year":"2010","unstructured":"Tarnowski M, Grymula K, Liu R et al (2010) Macrophage migration inhibitory factor is secreted by rhabdomyosarcoma cells, modulates tumor metastasis by binding to CXCR4 and CXCR7 receptors and inhibits recruitment of cancer-associated fibroblasts[J]. Mol Cancer Res 8(10):1328\u20131343","journal-title":"Mol Cancer Res"},{"key":"8936_CR44","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.bcp.2016.05.012","volume":"114","author":"M Szpakowska","year":"2016","unstructured":"Szpakowska M, Dupuis N, Baragli A et al (2016) Human herpesvirus 8-encoded chemokine vCCL2\/vMIP-II is an agonist of the atypical chemokine receptor ACKR3\/CXCR7[J]. Biochem Pharmacol 114:14\u201321","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"8936_CR45","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1002\/eji.201343907","volume":"44","author":"ML Humpert","year":"2014","unstructured":"Humpert ML, Pinto D, Jarrossay D et al (2014) CXCR7 influences the migration of B cells during maturation[J]. Eur J Immunol 44(3):694\u2013705","journal-title":"Eur J Immunol"},{"issue":"3","key":"8936_CR46","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.cell.2007.12.034","volume":"132","author":"B Boldajipour","year":"2008","unstructured":"Boldajipour B, Mahabaleshwar H, Kardash E et al (2008) Control of chemokine-guided cell migration by ligand sequestration[J]. Cell 132(3):463\u2013473","journal-title":"Cell"},{"issue":"2","key":"8936_CR47","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1182\/blood-2011-03-343608","volume":"119","author":"H Wang","year":"2012","unstructured":"Wang H, Beaty N, Chen S et al (2012) The CXCR7 chemokine receptor promotes B-cell retention in the splenic marginal zone and serves as a sink for CXCL12[J]. Blood 119(2):465\u2013468","journal-title":"Blood"},{"issue":"1","key":"8936_CR48","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1136\/annrheumdis-2019-215696","volume":"79","author":"L Kuang","year":"2020","unstructured":"Kuang L, Wu J, Su N et al (2020) FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice[J]. Ann Rheum Dis 79(1):112\u2013122","journal-title":"Ann Rheum Dis"},{"key":"8936_CR49","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/1476-4598-10-73","volume":"10","author":"BA Zabel","year":"2011","unstructured":"Zabel BA, Lew\u00e9n S, Berahovich RD et al (2011) The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells[J]. Mol Cancer 10:73","journal-title":"Mol Cancer"},{"key":"8936_CR50","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.semcancer.2019.12.007","volume":"65","author":"SK Daniel","year":"2020","unstructured":"Daniel SK, Seo YD, Pillarisetty VG (2020) The CXCL12-CXCR4\/CXCR7 axis as a mechanism of immune resistance in gastrointestinal malignancies[J]. Semin Cancer Biol 65:176\u2013188","journal-title":"Semin Cancer Biol"},{"issue":"3","key":"8936_CR51","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/s41419-019-1442-3","volume":"10","author":"S Xu","year":"2019","unstructured":"Xu S, Tang J, Wang C et al (2019) CXCR7 promotes melanoma tumorigenesis via Src kinase signaling[J]. Cell Death Dis 10(3):191","journal-title":"Cell Death Dis"},{"issue":"6","key":"8936_CR52","doi-asserted-by":"publisher","first-page":"929","DOI":"10.7150\/jca.23042","volume":"9","author":"TA Werner","year":"2018","unstructured":"Werner TA, Forster CM, Dizdar L et al (2018) CXCR4\/CXCR7\/CXCL12-axis in follicular thyroid carcinoma[J]. J Cancer 9(6):929\u2013940","journal-title":"J Cancer"},{"issue":"10","key":"8936_CR53","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1158\/0008-5472.CAN-18-2812","volume":"79","author":"S Li","year":"2019","unstructured":"Li S, Fong KW, Gritsina G et al (2019) Activation of MAPK Signaling by CXCR7 leads to enzalutamide resistance in prostate cancer[J]. Cancer Res 79(10):2580\u20132592","journal-title":"Cancer Res"},{"issue":"17","key":"8936_CR54","doi-asserted-by":"publisher","first-page":"4439","DOI":"10.1158\/0008-5472.CAN-19-0024","volume":"79","author":"JH Becker","year":"2019","unstructured":"Becker JH, Gao Y, Soucheray M et al (2019) CXCR7 reactivates ERK signaling to promote resistance to EGFR kinase inhibitors in NSCLC[J]. Cancer Res 79(17):4439\u20134452","journal-title":"Cancer Res"},{"issue":"1","key":"8936_CR55","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/icb.2016.68","volume":"95","author":"D Reimer","year":"2017","unstructured":"Reimer D, Lee AY, Bannan J et al (2017) Early CCR6 expression on B cells modulates germinal centre kinetics and efficient antibody responses[J]. Immunol Cell Biol 95(1):33\u201341","journal-title":"Immunol Cell Biol"},{"issue":"6","key":"8936_CR56","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/ng.583","volume":"42","author":"Y Kochi","year":"2010","unstructured":"Kochi Y, Okada Y, Suzuki A et al (2010) A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility[J]. Nat Genet 42(6):515\u2013519","journal-title":"Nat Genet"},{"issue":"6","key":"8936_CR57","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.immuni.2017.11.022","volume":"47","author":"D Suan","year":"2017","unstructured":"Suan D, Kr\u00e4utler NJ, Maag J et al (2017) CCR6 defines memory B cell precursors in mouse and human germinal centers, revealing light-zone location and predominant low antigen affinity[J]. Immunity 47(6):1142\u20131153","journal-title":"Immunity"},{"key":"8936_CR58","doi-asserted-by":"publisher","first-page":"805","DOI":"10.3389\/fimmu.2017.00805","volume":"8","author":"YL Lin","year":"2017","unstructured":"Lin YL, Ip PP, Liao F (2017) CCR6 Deficiency impairs IgA production and dysregulates antimicrobial peptide production, altering the intestinal flora[J]. Front Immunol 8:805","journal-title":"Front Immunol"},{"issue":"11","key":"8936_CR59","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1084\/jem.20181868","volume":"216","author":"AR Albright","year":"2019","unstructured":"Albright AR, Kabat J, Li M et al (2019) TGF\u03b2 signaling in germinal center B cells promotes the transition from light zone to dark zone[J]. J Exp Med 216(11):2531\u20132545","journal-title":"J Exp Med"},{"issue":"5","key":"8936_CR60","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1111\/his.13802","volume":"74","author":"H Ryota","year":"2019","unstructured":"Ryota H, Ishida M, Satoi S et al (2019) Clinicopathological and immunological features of follicular pancreatitis - a distinct disease entity characterised by Th17 activation[J]. Histopathology 74(5):709\u2013717","journal-title":"Histopathology"},{"key":"8936_CR61","doi-asserted-by":"crossref","unstructured":"Bonami RH, Nyhoff LE, McNitt DH et al (2020) T-B Lymphocyte interactions promote type 1 diabetes independently of SLAM-associated protein[J]. J Immunol","DOI":"10.4049\/jimmunol.1900464"},{"issue":"3","key":"8936_CR62","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.immuni.2008.08.006","volume":"29","author":"D Alvarez","year":"2008","unstructured":"Alvarez D, Vollmann EH, von Andrian UH (2008) Mechanisms and consequences of dendritic cell migration[J]. Immunity 29(3):325\u2013342","journal-title":"Immunity"},{"key":"8936_CR63","doi-asserted-by":"crossref","unstructured":"Hashizume-Takizawa T, Kobayashi R, Tsuzukibashi O et al (2019) CCR7-deficient mice exhibit a delayed antigen-specific mucosal IgA antibody response to an oral recombinant Salmonella strain[J]. Pathog Dis 77(3)","DOI":"10.1093\/femspd\/ftz024"},{"issue":"7493","key":"8936_CR64","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/nature12910","volume":"507","author":"X Liu","year":"2014","unstructured":"Liu X, Chen X, Zhong B et al (2014) Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development[J]. Nature 507(7493):513\u2013518","journal-title":"Nature"},{"issue":"3","key":"8936_CR65","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1084\/jem.20171067","volume":"215","author":"EE Kara","year":"2018","unstructured":"Kara EE, Bastow CR, McKenzie DR et al (2018) Atypical chemokine receptor 4 shapes activated B cell fate[J]. J Exp Med 215(3):801\u2013813","journal-title":"J Exp Med"},{"issue":"4","key":"8936_CR66","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1128\/jvi.67.4.2209-2220.1993","volume":"67","author":"M Birkenbach","year":"1993","unstructured":"Birkenbach M, Josefsen K, Yalamanchili R et al (1993) Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors[J]. J Virol 67(4):2209\u20132220","journal-title":"J Virol"},{"issue":"7357","key":"8936_CR67","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/nature10280","volume":"475","author":"S Hannedouche","year":"2011","unstructured":"Hannedouche S, Zhang J, Yi T et al (2011) Oxysterols direct immune cell migration via EBI2[J]. Nature 475(7357):524\u2013527","journal-title":"Nature"},{"issue":"7259","key":"8936_CR68","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1038\/nature08226","volume":"460","author":"JP Pereira","year":"2009","unstructured":"Pereira JP, Kelly LM, Xu Y et al (2009) EBI2 mediates B cell segregation between the outer and centre follicle[J]. Nature 460(7259):1122\u20131126","journal-title":"Nature"},{"issue":"2","key":"8936_CR69","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.immuni.2009.06.016","volume":"31","author":"D Gatto","year":"2009","unstructured":"Gatto D, Paus D, Basten A et al (2009) Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses[J]. Immunity 31(2):259\u2013269","journal-title":"Immunity"},{"issue":"9","key":"8936_CR70","doi-asserted-by":"publisher","first-page":"4621","DOI":"10.4049\/jimmunol.1101542","volume":"187","author":"D Gatto","year":"2011","unstructured":"Gatto D, Wood K, Brink R (2011) EBI2 operates independently of but in cooperation with CXCR5 and CCR7 to direct B cell migration and organization in follicles and the germinal center[J]. J Immunol 187(9):4621\u20134628","journal-title":"J Immunol"},{"issue":"4","key":"8936_CR71","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.immuni.2015.03.002","volume":"42","author":"D Suan","year":"2015","unstructured":"Suan D, Nguyen A, Moran I et al (2015) T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses[J]. Immunity 42(4):704\u2013718","journal-title":"Immunity"},{"issue":"7601","key":"8936_CR72","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/nature17947","volume":"533","author":"J Li","year":"2016","unstructured":"Li J, Lu E, Yi T et al (2016) EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells[J]. Nature 533(7601):110\u2013114","journal-title":"Nature"},{"issue":"7","key":"8936_CR73","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1182\/blood-2016-02-697185","volume":"129","author":"AK Niss","year":"2017","unstructured":"Niss AK, Barington L, Benned-Jensen T et al (2017) EBI2 overexpression in mice leads to B1 B-cell expansion and chronic lymphocytic leukemia-like B-cell malignancies[J]. Blood 129(7):866\u2013878","journal-title":"Blood"},{"issue":"4","key":"8936_CR74","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/cea.12878","volume":"47","author":"S Feldman","year":"2017","unstructured":"Feldman S, Kasjanski R, Poposki J et al (2017) Chronic airway inflammation provides a unique environment for B cell activation and antibody production[J]. Clin Exp Allergy 47(4):457\u2013466","journal-title":"Clin Exp Allergy"},{"issue":"7","key":"8936_CR75","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1084\/jem.20141827","volume":"212","author":"MJ Barnes","year":"2015","unstructured":"Barnes MJ, Li CM, Xu Y et al (2015) The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function[J]. J Exp Med 212(7):1011\u20131020","journal-title":"J Exp Med"},{"issue":"3","key":"8936_CR76","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/s41419-019-1462-z","volume":"10","author":"D Qiu","year":"2019","unstructured":"Qiu D, Chu X, Hua L et al (2019) Gpr174-deficient regulatory T cells decrease cytokine storm in septic mice[J]. Cell Death Dis 10(3):233","journal-title":"Cell Death Dis"},{"key":"8936_CR77","doi-asserted-by":"crossref","unstructured":"Zhu M, Li C, Song Z et al (2020) The increased marginal zone B cells attenuates early inflammatory responses during sepsis in Gpr174 deficient mice[J]. Int Immunopharmacol 81:106034","DOI":"10.1016\/j.intimp.2019.106034"},{"issue":"7","key":"8936_CR78","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1136\/jmedgenet-2013-101595","volume":"50","author":"X Chu","year":"2013","unstructured":"Chu X, Shen M, Xie F et al (2013) An X chromosome-wide association analysis identifies variants in GPR174 as a risk factor for Graves\u2019 disease[J]. J Med Genet 50(7):479\u2013485","journal-title":"J Med Genet"},{"key":"8936_CR79","doi-asserted-by":"crossref","unstructured":"Yue J, Zhao X (2020) GPR174 suppression attenuates retinopathy in angiotensin II (Ang II)-treated mice by reducing inflammation via PI3K\/AKT signaling[J]. Biomed Pharmacother 122:109701","DOI":"10.1016\/j.biopha.2019.109701"},{"issue":"4","key":"8936_CR80","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.immuni.2017.03.015","volume":"46","author":"JE Konkel","year":"2017","unstructured":"Konkel JE, Zhang D, Zanvit P et al (2017) Transforming growth factor-\u03b2 signaling in regulatory T cells controls T helper-17 cells and tissue-specific immune responses[J]. Immunity 46(4):660\u2013674","journal-title":"Immunity"},{"issue":"7790","key":"8936_CR81","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/s41586-019-1873-0","volume":"577","author":"R Zhao","year":"2020","unstructured":"Zhao R, Chen X, Ma W et al (2020) A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity[J]. Nature 577(7790):416\u2013420","journal-title":"Nature"},{"issue":"10","key":"8936_CR82","doi-asserted-by":"publisher","first-page":"3879","DOI":"10.1073\/pnas.1121343109","volume":"109","author":"JG Lohr","year":"2012","unstructured":"Lohr JG, Stojanov P, Lawrence MS et al (2012) Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing[J]. Proc Natl Acad Sci U S A 109(10):3879\u20133884","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7530","key":"8936_CR83","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/nature13765","volume":"516","author":"JR Muppidi","year":"2014","unstructured":"Muppidi JR, Schmitz R, Green JA et al (2014) Loss of signalling via G\u03b113 in germinal centre B-cell-derived lymphoma[J]. Nature 516(7530):254\u2013258","journal-title":"Nature"},{"issue":"2","key":"8936_CR84","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/gcc.22421","volume":"56","author":"H Dou","year":"2017","unstructured":"Dou H, Chen X, Huang Y et al (2017) Prognostic significance of P2RY8-CRLF2 and CRLF2 overexpression may vary across risk subgroups of childhood B-cell acute lymphoblastic leukemia[J]. Genes Chromosomes Cancer 56(2):135\u2013146","journal-title":"Genes Chromosomes Cancer"},{"issue":"4","key":"8936_CR85","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1038\/s41375-018-0297-4","volume":"33","author":"N Potter","year":"2019","unstructured":"Potter N, Jones L, Blair H et al (2019) Single-cell analysis identifies CRLF2 rearrangements as both early and late events in Down syndrome and non-Down syndrome acute lymphoblastic leukaemia[J]. Leukemia 33(4):893\u2013904","journal-title":"Leukemia"},{"issue":"13","key":"8936_CR86","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1084\/jem.20151250","volume":"212","author":"JR Muppidi","year":"2015","unstructured":"Muppidi JR, Lu E, Cyster JG (2015) The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination[J]. J Exp Med 212(13):2213\u20132222","journal-title":"J Exp Med"},{"issue":"7747","key":"8936_CR87","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/s41586-019-1003-z","volume":"567","author":"E Lu","year":"2019","unstructured":"Lu E, Wolfreys FD, Muppidi JR et al (2019) S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8[J]. Nature 567(7747):244\u2013248","journal-title":"Nature"},{"issue":"10","key":"8936_CR88","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1084\/jem.20080809","volume":"205","author":"V Brune","year":"2008","unstructured":"Brune V, Tiacci E, Pfeil I et al (2008) Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis[J]. J Exp Med 205(10):2251\u20132268","journal-title":"J Exp Med"},{"key":"8936_CR89","doi-asserted-by":"crossref","unstructured":"He Y, Gallman AE, Xie C et al (2022) P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance[J]. J Exp Med\u00a0219(1)","DOI":"10.1084\/jem.20211004"},{"issue":"3","key":"8936_CR90","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.4049\/jimmunol.1001983","volume":"186","author":"A Chang","year":"2011","unstructured":"Chang A, Henderson SG, Brandt D et al (2011) In situ B cell-mediated immune responses and tubulointerstitial inflammation in human lupus nephritis[J]. J Immunol 186(3):1849\u20131860","journal-title":"J Immunol"},{"issue":"1","key":"8936_CR91","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41591-018-0254-9","volume":"25","author":"S Caielli","year":"2019","unstructured":"Caielli S, Veiga DT, Balasubramanian P et al (2019) A CD4(+) T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate[J]. Nat Med 25(1):75\u201381","journal-title":"Nat Med"},{"issue":"10","key":"8936_CR92","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1038\/cmi.2016.47","volume":"14","author":"LD Zhao","year":"2017","unstructured":"Zhao LD, Liang D, Wu XN et al (2017) Contribution and underlying mechanisms of CXCR4 overexpression in patients with systemic lupus erythematosus[J]. Cell Mol Immunol 14(10):842\u2013849","journal-title":"Cell Mol Immunol"},{"key":"8936_CR93","doi-asserted-by":"crossref","unstructured":"Kiso K, Yoshifuji H, Oku T et al (2017) Transgelin-2 is upregulated on activated B-cells and expressed in hyperplastic follicles in lupus erythematosus patients[J]. PLoS One 12(9):e184738","DOI":"10.1371\/journal.pone.0184738"},{"issue":"5","key":"8936_CR94","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.jaci.2020.03.036","volume":"146","author":"AR Kim","year":"2020","unstructured":"Kim AR, Han D, Choi JY et al (2020) Targeting inducible costimulator expressed on CXCR5(+)PD-1(+) T(H) cells suppresses the progression of pemphigus vulgaris[J]. J Allergy Clin Immunol 146(5):1070\u20131079","journal-title":"J Allergy Clin Immunol"},{"key":"8936_CR95","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.molimm.2019.07.002","volume":"114","author":"Y Wang","year":"2019","unstructured":"Wang Y, Zhang S, Liang Z et al (2019) Metformin attenuates bleomycin-induced scleroderma by regulating the balance of Treg\/Teff cells and reducing spleen germinal center formation[J]. Mol Immunol 114:72\u201380","journal-title":"Mol Immunol"},{"issue":"2","key":"8936_CR96","first-page":"e118","volume":"166","author":"G Elia","year":"2015","unstructured":"Elia G (2015) Dermatomyositis and chemokines[J]. Clin Ter 166(2):e118\u2013e121","journal-title":"Clin Ter"},{"issue":"1","key":"8936_CR97","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1111\/cei.12311","volume":"177","author":"T Fujiyama","year":"2014","unstructured":"Fujiyama T, Ito T, Ogawa N et al (2014) Preferential infiltration of interleukin-4-producing CXCR4+ T cells in the lesional muscle but not skin of patients with dermatomyositis[J]. Clin Exp Immunol 177(1):110\u2013120","journal-title":"Clin Exp Immunol"},{"issue":"6","key":"8936_CR98","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/s11427-017-9269-8","volume":"61","author":"R Xing","year":"2018","unstructured":"Xing R, Liu F, Yang Y et al (2018) GPR54 deficiency reduces the Treg population and aggravates experimental autoimmune encephalomyelitis in mice[J]. Sci China Life Sci 61(6):675\u2013687","journal-title":"Sci China Life Sci"},{"issue":"1","key":"8936_CR99","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1038\/s41467-019-10018-1","volume":"10","author":"KL Truong","year":"2019","unstructured":"Truong KL, Schlickeiser S, Vogt K et al (2019) Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4(+) memory T cells[J]. Nat Commun 10(1):2263","journal-title":"Nat Commun"},{"issue":"1\u20133","key":"8936_CR100","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.ejphar.2012.03.007","volume":"683","author":"Y Onozawa","year":"2012","unstructured":"Onozawa Y, Fujita Y, Kuwabara H et al (2012) Activation of T cell death-associated gene 8 regulates the cytokine production of T cells and macrophages in vitro[J]. Eur J Pharmacol 683(1\u20133):325\u2013331","journal-title":"Eur J Pharmacol"},{"key":"8936_CR101","doi-asserted-by":"crossref","unstructured":"Robert R, Mackay CR (2018) G\u03b1s-coupled GPCRs GPR65 and GPR174. Downers for immune responses[J]. Immunol Cell Biol 96(4):341\u2013343","DOI":"10.1111\/imcb.12027"},{"issue":"6","key":"8936_CR102","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1016\/j.immuni.2016.05.007","volume":"44","author":"KG Lassen","year":"2016","unstructured":"Lassen KG, McKenzie CI, Mari M et al (2016) Genetic coding variant in GPR65 alters lysosomal pH and links lysosomal dysfunction with colitis risk[J]. Immunity 44(6):1392\u20131405","journal-title":"Immunity"},{"issue":"2","key":"8936_CR103","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1111\/imcb.1031","volume":"96","author":"RC Wirasinha","year":"2018","unstructured":"Wirasinha RC, Vijayan D, Smith NJ et al (2018) GPR65 inhibits experimental autoimmune encephalomyelitis through CD4(+) T cell independent mechanisms that include effects on iNKT cells[J]. Immunol Cell Biol 96(2):128\u2013136","journal-title":"Immunol Cell Biol"},{"key":"8936_CR104","doi-asserted-by":"crossref","unstructured":"Xiong Y, Piao W, Brinkman CC et al (2019) CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration[J]. Sci Immunol 4(33)","DOI":"10.1126\/sciimmunol.aav1263"},{"issue":"1","key":"8936_CR105","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nrc.2017.96","volume":"18","author":"B Ogretmen","year":"2018","unstructured":"Ogretmen B (2018) Sphingolipid metabolism in cancer signalling and therapy[J]. Nat Rev Cancer 18(1):33\u201350","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"8936_CR106","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1007\/s13311-017-0565-4","volume":"14","author":"BZ Chaudhry","year":"2017","unstructured":"Chaudhry BZ, Cohen JA, Conway DS (2017) Sphingosine 1-phosphate receptor modulators for the treatment of multiple sclerosis[J]. Neurotherapeutics 14(4):859\u2013873","journal-title":"Neurotherapeutics"},{"key":"8936_CR107","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3389\/fphar.2019.00212","volume":"10","author":"T P\u00e9rez-Jeldres","year":"2019","unstructured":"P\u00e9rez-Jeldres T, Tyler CJ, Boyer JD et al (2019) Targeting cytokine signaling and lymphocyte traffic via small molecules in inflammatory bowel disease: JAK Inhibitors and S1PR Agonists[J]. Front Pharmacol 10:212","journal-title":"Front Pharmacol"},{"key":"8936_CR108","doi-asserted-by":"crossref","unstructured":"Sukocheva OA, Furuya H, Ng ML et al (2020) Sphingosine kinase and sphingosine-1-phosphate receptor signaling pathway in inflammatory gastrointestinal disease and cancers: a novel therapeutic target[J]. Pharmacol Ther 207:107464","DOI":"10.1016\/j.pharmthera.2019.107464"},{"key":"8936_CR109","doi-asserted-by":"crossref","unstructured":"Cartier A, Hla T (2019) Sphingosine 1-phosphate: lipid signaling in pathology and therapy[J]. Science 366(6463)","DOI":"10.1126\/science.aar5551"},{"key":"8936_CR110","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.pharmthera.2017.11.001","volume":"185","author":"A Huwiler","year":"2018","unstructured":"Huwiler A, Zangemeister-Wittke U (2018) The sphingosine 1-phosphate receptor modulator fingolimod as a therapeutic agent: recent findings and new perspectives[J]. Pharmacol Ther 185:34\u201349","journal-title":"Pharmacol Ther"},{"issue":"1","key":"8936_CR111","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1084\/jem.194.1.45","volume":"194","author":"DC Hargreaves","year":"2001","unstructured":"Hargreaves DC, Hyman PL, Lu TT et al (2001) A coordinated change in chemokine responsiveness guides plasma cell movements[J]. J Exp Med 194(1):45\u201356","journal-title":"J Exp Med"},{"key":"8936_CR112","doi-asserted-by":"crossref","unstructured":"Hao H, Nakayamada S, Yamagata K et al (2020) Conversion of T follicular helper cells to T follicular regulatory cells by interleukin-2 through transcriptional regulation in systemic lupus erythematosus[J]. Arthritis Rheumatol","DOI":"10.1002\/art.41457"},{"issue":"7","key":"8936_CR113","doi-asserted-by":"publisher","first-page":"3717","DOI":"10.1172\/JCI129018","volume":"130","author":"Z Wang","year":"2020","unstructured":"Wang Z, Zhao M, Yin J et al (2020) E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases[J]. J Clin Invest 130(7):3717\u20133733","journal-title":"J Clin Invest"},{"key":"8936_CR114","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.intimp.2018.01.038","volume":"56","author":"C Liu","year":"2018","unstructured":"Liu C, Wang D, Song Y et al (2018) Increased circulating CD4(+)CXCR5(+)FoxP3(+) follicular regulatory T cells correlated with severity of systemic lupus erythematosus patients[J]. Int Immunopharmacol 56:261\u2013268","journal-title":"Int Immunopharmacol"},{"key":"8936_CR115","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molimm.2020.06.003","volume":"125","author":"G Cao","year":"2020","unstructured":"Cao G, Wang P, Cui Z et al (2020) An imbalance between blood CD4(+)CXCR5(+)Foxp3(+) Tfr cells and CD4(+)CXCR5(+)Tfh cells may contribute to the immunopathogenesis of rheumatoid arthritis[J]. Mol Immunol 125:1\u20138","journal-title":"Mol Immunol"},{"issue":"6","key":"8936_CR116","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1111\/sji.12616","volume":"86","author":"J Zheng","year":"2017","unstructured":"Zheng J, Wang T, Zhang L et al (2017) Dysregulation of circulating Tfr\/Tfh ratio in primary biliary cholangitis[J]. Scand J Immunol 86(6):452\u2013461","journal-title":"Scand J Immunol"},{"issue":"11","key":"8936_CR117","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1038\/ng.3415","volume":"47","author":"K Kataoka","year":"2015","unstructured":"Kataoka K, Nagata Y, Kitanaka A et al (2015) Integrated molecular analysis of adult T cell leukemia\/lymphoma[J]. Nat Genet 47(11):1304\u20131315","journal-title":"Nat Genet"},{"issue":"17","key":"8936_CR118","doi-asserted-by":"publisher","first-page":"3026","DOI":"10.2174\/0929867324666170830111531","volume":"26","author":"W Zhou","year":"2019","unstructured":"Zhou W, Guo S, Liu M et al (2019) Targeting CXCL12\/CXCR4 axis in tumor immunotherapy[J]. Curr Med Chem 26(17):3026\u20133041","journal-title":"Curr Med Chem"},{"issue":"4","key":"8936_CR119","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1161\/CIRCULATIONAHA.117.027646","volume":"136","author":"Y D\u00f6ring","year":"2017","unstructured":"D\u00f6ring Y, Noels H, van der Vorst E et al (2017) Vascular CXCR4 limits atherosclerosis by maintaining arterial integrity: evidence from mouse and human studies[J]. Circulation 136(4):388\u2013403","journal-title":"Circulation"},{"issue":"3","key":"8936_CR120","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1111\/j.1476-5381.2011.01648.x","volume":"166","author":"DJ Scholten","year":"2012","unstructured":"Scholten DJ, Canals M, Wijtmans M et al (2012) Pharmacological characterization of a small-molecule agonist for the chemokine receptor CXCR3[J]. Br J Pharmacol 166(3):898\u2013911","journal-title":"Br J Pharmacol"},{"key":"8936_CR121","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.3389\/fonc.2020.01672","volume":"10","author":"D Cancilla","year":"2020","unstructured":"Cancilla D, Rettig MP, DiPersio JF (2020) Targeting CXCR4 in AML and ALL[J]. Front Oncol 10:1672","journal-title":"Front Oncol"},{"issue":"6","key":"8936_CR122","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1124\/mol.119.117663","volume":"96","author":"I Adlere","year":"2019","unstructured":"Adlere I, Caspar B, Arimont M et al (2019) Modulators of CXCR4 and CXCR7\/ACKR3 function[J]. Mol Pharmacol 96(6):737\u2013752","journal-title":"Mol Pharmacol"},{"issue":"6152","key":"8936_CR123","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1126\/science.1241475","volume":"341","author":"Q Tan","year":"2013","unstructured":"Tan Q, Zhu Y, Li J et al (2013) Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex[J]. Science 341(6152):1387\u20131390","journal-title":"Science"},{"issue":"1","key":"8936_CR124","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1111\/imr.12762","volume":"289","author":"JM Richmond","year":"2019","unstructured":"Richmond JM, Strassner JP, Essien KI et al (2019) T-cell positioning by chemokines in autoimmune skin diseases[J]. Immunol Rev 289(1):186\u2013204","journal-title":"Immunol Rev"},{"key":"8936_CR125","doi-asserted-by":"crossref","unstructured":"Rizeq B, Malki MI (2020) The Role of CCL21\/CCR7 chemokine axis in breast cancer progression[J]. Cancers (Basel) 12(4)","DOI":"10.3390\/cancers12041036"},{"key":"8936_CR126","doi-asserted-by":"crossref","unstructured":"Salem A, Alotaibi M, Mroueh R et al (2021) CCR7 as a therapeutic target in cancer[J]. Biochim Biophys Acta Rev Cancer\u00a01875(1):188499","DOI":"10.1016\/j.bbcan.2020.188499"},{"issue":"2","key":"8936_CR127","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1124\/jpet.120.000105","volume":"375","author":"K Braden","year":"2020","unstructured":"Braden K, Giancotti LA, Chen Z et al (2020) GPR183-oxysterol axis in spinal cord contributes to neuropathic pain[J]. J Pharmacol Exp Ther 375(2):367\u2013375","journal-title":"J Pharmacol Exp Ther"},{"issue":"16","key":"8936_CR128","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1111\/bph.15311","volume":"178","author":"B Misselwitz","year":"2021","unstructured":"Misselwitz B, Wyss A, Raselli T et al (2021) The oxysterol receptor GPR183 in inflammatory bowel diseases[J]. Br J Pharmacol 178(16):3140\u20133156","journal-title":"Br J Pharmacol"},{"key":"8936_CR129","doi-asserted-by":"crossref","unstructured":"Kjaer V, Ieremias L, Daugvilaite V et al (2021) Discovery of GPR183 agonists based on an antagonist scaffold[J]. ChemMedChem","DOI":"10.1002\/cmdc.202100301"}],"container-title":["Clinical Reviews in Allergy &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-022-08936-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12016-022-08936-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-022-08936-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T20:11:09Z","timestamp":1668888669000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12016-022-08936-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,8]]},"references-count":129,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["8936"],"URL":"https:\/\/doi.org\/10.1007\/s12016-022-08936-y","relation":{},"ISSN":["1559-0267"],"issn-type":[{"value":"1559-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,8]]},"assertion":[{"value":"23 March 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}