{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:43:10Z","timestamp":1793839390422,"version":"4.6.1"},"reference-count":225,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T00:00:00Z","timestamp":1655510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T00:00:00Z","timestamp":1655510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["RF-2016-02364842"],"award-info":[{"award-number":["RF-2016-02364842"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["RF-2016-02364842"],"award-info":[{"award-number":["RF-2016-02364842"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["RF-2016-02364842"],"award-info":[{"award-number":["RF-2016-02364842"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clinic Rev Allerg Immunol"],"DOI":"10.1007\/s12016-022-08941-1","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T05:02:53Z","timestamp":1655528573000},"page":"222-238","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":409,"title":["Inflammaging and Osteoarthritis"],"prefix":"10.1007","volume":"64","author":[{"given":"Francesca","family":"Motta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Barone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Sica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0323-0376","authenticated-orcid":false,"given":"Carlo","family":"Selmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,18]]},"reference":[{"key":"8941_CR1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/0049-0172(84)90002-7","volume":"14","author":"JH Bland","year":"1984","unstructured":"Bland JH, Cooper SM (1984) Osteoarthritis: a review of the cell biology involved and evidence for reversibility. Management rationally related to known genesis and pathophysiology. Semin Arthritis Rheum 14:106\u2013133","journal-title":"Semin Arthritis Rheum"},{"key":"8941_CR2","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1136\/ard.48.11.958","volume":"48","author":"CW Hutton","year":"1989","unstructured":"Hutton CW (1989) Osteoarthritis: the cause not result of joint failure? Ann Rheum Dis 48:958\u2013961. https:\/\/doi.org\/10.1136\/ard.48.11.958","journal-title":"Ann Rheum Dis"},{"key":"8941_CR3","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/bmb\/lds038","volume":"105","author":"A Litwic","year":"2013","unstructured":"Litwic A, Edwards MH, Dennison EM, Cooper C (2013) Epidemiology and burden of osteoarthritis. Br Med Bull 105:185\u2013199. https:\/\/doi.org\/10.1093\/bmb\/lds038","journal-title":"Br Med Bull"},{"key":"8941_CR4","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1002\/art.1780340502","volume":"34","author":"R Altman","year":"1991","unstructured":"Altman R, Alarc\u00f3n G, Appelrouth D et al (1991) The American college of rheumatology criteria for the classification and reporting of osteoarthritis of the hip. Arthritis Rheum 34:505\u2013514. https:\/\/doi.org\/10.1002\/art.1780340502","journal-title":"Arthritis Rheum"},{"key":"8941_CR5","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1002\/art.1780290816","volume":"29","author":"R Altman","year":"1986","unstructured":"Altman R, Asch E, Bloch D et al (1986) Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Arthritis Rheum 29:1039\u20131049. https:\/\/doi.org\/10.1002\/art.1780290816","journal-title":"Arthritis Rheum"},{"key":"8941_CR6","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1002\/art.1780331101","volume":"33","author":"R Altman","year":"1990","unstructured":"Altman R, Alarcon G, Appelrouth D et al (1990) The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand. Arthritis Rheum 33:1601\u20131610. https:\/\/doi.org\/10.1002\/art.1780331101","journal-title":"Arthritis Rheum"},{"key":"8941_CR7","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1136\/ard.16.4.494","volume":"16","author":"JH Kellgren","year":"1957","unstructured":"Kellgren JH, Lawrence JS (1957) Radiological assessment of osteoarthrosis. Ann Rheum Dis 16:494\u2013502. https:\/\/doi.org\/10.1136\/ard.16.4.494","journal-title":"Ann Rheum Dis"},{"key":"8941_CR8","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1002\/art.34453","volume":"64","author":"RF Loeser","year":"2012","unstructured":"Loeser RF, Goldring SR, Scanzello CR, Goldring MB (2012) Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum 64:1697\u20131707","journal-title":"Arthritis Rheum"},{"key":"8941_CR9","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1002\/art.38611","volume":"66","author":"L Sharma","year":"2014","unstructured":"Sharma L, Chmiel JS, Almagor O et al (2014) Significance of preradiographic magnetic resonance imaging lesions in persons at increased risk of knee osteoarthritis. Arthritis Rheumatol 66:1811\u20131819. https:\/\/doi.org\/10.1002\/art.38611","journal-title":"Arthritis Rheumatol"},{"key":"8941_CR10","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1016\/S0140-6736(20)32230-3","volume":"396","author":"DJ Hunter","year":"2020","unstructured":"Hunter DJ, March L, Chew M (2020) Osteoarthritis in 2020 and beyond: a Lancet Commission. Lancet 396:1711\u20131712","journal-title":"Lancet"},{"key":"8941_CR11","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.cger.2010.03.001","volume":"26","author":"Y Zhang","year":"2010","unstructured":"Zhang Y, Jordan JM (2010) Epidemiology of osteoarthritis. Clin Geriatr Med 26:355\u2013369","journal-title":"Clin Geriatr Med"},{"key":"8941_CR12","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/art.23176","volume":"58","author":"RC Lawrence","year":"2008","unstructured":"Lawrence RC, Felson DT, Helmick CG et al (2008) Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II Arthritis Rheum 58:26\u201335. https:\/\/doi.org\/10.1002\/art.23176","journal-title":"Part II Arthritis Rheum"},{"key":"8941_CR13","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1093\/aje\/kwf141","volume":"156","author":"Y Zhang","year":"2002","unstructured":"Zhang Y, Niu J, Kelly-Hayes M et al (2002) Prevalence of symptomatic hand osteoarthritis and its impact on functional status among the elderly: the Framingham study. Am J Epidemiol 156:1021\u20131027. https:\/\/doi.org\/10.1093\/aje\/kwf141","journal-title":"Am J Epidemiol"},{"key":"8941_CR14","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1007\/s40273-016-0424-x","volume":"34","author":"F Xie","year":"2016","unstructured":"Xie F, Kovic B, Jin X et al (2016) Economic and humanistic burden of osteoarthritis: A systematic review of large sample studies. Pharmacoeconomics 34:1087\u20131100","journal-title":"Pharmacoeconomics"},{"key":"8941_CR15","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1002\/acr.22909","volume":"69","author":"J Hubertsson","year":"2017","unstructured":"Hubertsson J, Turkiewicz A, Petersson IF, Englund M (2017) Understanding occupation, sick leave, and disability pension due to knee and hip osteoarthritis from a sex perspective. Arthritis Care Res 69:226\u2013233. https:\/\/doi.org\/10.1002\/acr.22909","journal-title":"Arthritis Care Res"},{"key":"8941_CR16","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1136\/annrheumdis-2013-204763","volume":"73","author":"M Cross","year":"2014","unstructured":"Cross M, Smith E, Hoy D et al (2014) The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis 73:1323\u20131330. https:\/\/doi.org\/10.1136\/annrheumdis-2013-204763","journal-title":"Ann Rheum Dis"},{"key":"8941_CR17","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1093\/gerona\/glw014","volume":"71","author":"MN Haan","year":"2016","unstructured":"Haan MN, Lee A, Odden MC et al (2016) Gender differences in the combined effects of cardiovascular disease and osteoarthritis on progression to functional impairment in older Mexican Americans. J Gerontol - Ser A Biol Sci Med Sci 71:1089\u20131095. https:\/\/doi.org\/10.1093\/gerona\/glw014","journal-title":"J Gerontol - Ser A Biol Sci Med Sci"},{"key":"8941_CR18","doi-asserted-by":"publisher","unstructured":"Park JI, Jung HH (2017)\u00a0Estimation of years lived with disability due to noncommunicable diseases and injuries using a population-representative survey. PLoS ONE 12.\u00a0https:\/\/doi.org\/10.1371\/journal.pone.0172001","DOI":"10.1371\/journal.pone.0172001"},{"key":"8941_CR19","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1093\/ageing\/afw216","volume":"46","author":"N Veronese","year":"2017","unstructured":"Veronese N, Stubbs B, Solmi M et al (2017) Association between lower limb osteoarthritis and incidence of depressive symptoms: data from the osteoarthritis initiative. Age Ageing 46:470\u2013476. https:\/\/doi.org\/10.1093\/ageing\/afw216","journal-title":"Age Ageing"},{"key":"8941_CR20","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.comppsych.2016.12.001","volume":"73","author":"SY Kye","year":"2017","unstructured":"Kye SY, Park K (2017) Suicidal ideation and suicidal attempts among adults with chronic diseases: a cross-sectional study. Compr Psychiatry 73:160\u2013167. https:\/\/doi.org\/10.1016\/j.comppsych.2016.12.001","journal-title":"Compr Psychiatry"},{"key":"8941_CR21","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1093\/pm\/pnx107","volume":"19","author":"KE Innes","year":"2018","unstructured":"Innes KE, Sambamoorthi U (2018) The association of perceived memory loss with osteoarthritis and related joint pain in a large Appalachian population. Pain Med (United States) 19:1340\u20131356. https:\/\/doi.org\/10.1093\/pm\/pnx107","journal-title":"Pain Med (United States)"},{"key":"8941_CR22","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1136\/annrheumdis-2016-210275","volume":"76","author":"O Schieir","year":"2017","unstructured":"Schieir O, Tosevski C, Glazier RH et al (2017) Incident myocardial infarction associated with major types of arthritis in the general population: a systematic review and meta-analysis. Ann Rheum Dis 76:1396\u20131404. https:\/\/doi.org\/10.1136\/annrheumdis-2016-210275","journal-title":"Ann Rheum Dis"},{"key":"8941_CR23","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1007\/s10067-016-3391-x","volume":"35","author":"WS Chung","year":"2016","unstructured":"Chung WS, Lin HH, Ho FM et al (2016) Risks of acute coronary syndrome in patients with osteoarthritis: a nationwide population-based cohort study. Clin Rheumatol 35:2807\u20132813. https:\/\/doi.org\/10.1007\/s10067-016-3391-x","journal-title":"Clin Rheumatol"},{"key":"8941_CR24","doi-asserted-by":"publisher","unstructured":"Courties A, Sellam J, Maheu E et al (2017)\u00a0Coronary heart disease is associated with a worse clinical outcome of hand osteoarthritis: a cross-sectional and longitudinal study. RMD Open 3.\u00a0https:\/\/doi.org\/10.1136\/rmdopen-2016-000344","DOI":"10.1136\/rmdopen-2016-000344"},{"key":"8941_CR25","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-209026","volume":"75","author":"SG Gao","year":"2016","unstructured":"Gao SG, Zeng C, Xiong YL et al (2016) Is painful knee an independent predictor of mortality in middle-aged women? Ann Rheum Dis 75:e22","journal-title":"Ann Rheum Dis"},{"key":"8941_CR26","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.cger.2014.08.019","volume":"31","author":"SR Piva","year":"2015","unstructured":"Piva SR, Susko AM, Khoja SS et al (2015) Links between osteoarthritis and diabetes: implications for management from a physical activity perspective. Clin Geriatr Med 31:67\u201387","journal-title":"Clin Geriatr Med"},{"key":"8941_CR27","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.joca.2016.08.003","volume":"25","author":"GA Hawker","year":"2017","unstructured":"Hawker GA, Croxford R, Bierman AS et al (2017) Osteoarthritis-related difficulty walking and risk for diabetes complications. Osteoarthr Cartil 25:67\u201375. https:\/\/doi.org\/10.1016\/j.joca.2016.08.003","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR28","doi-asserted-by":"publisher","first-page":"744","DOI":"10.2337\/dc06-1842","volume":"30","author":"CY Jeon","year":"2007","unstructured":"Jeon CY, Lokken RP, Hu FB, Van Dam RM (2007) Physical activity of moderate intensity and risk of type 2 diabetes: a systematic review. Diabetes Care 30:744\u2013752","journal-title":"Diabetes Care"},{"key":"8941_CR29","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1001\/jama.2013.277669","volume":"310","author":"SP Messier","year":"2013","unstructured":"Messier SP, Mihalko SL, Legault C et al (2013) Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: The IDEA randomized clinical trial. JAMA - J Am Med Assoc 310:1263\u20131273. https:\/\/doi.org\/10.1001\/jama.2013.277669","journal-title":"JAMA - J Am Med Assoc"},{"key":"8941_CR30","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.2337\/diabetes.52.7.1799","volume":"52","author":"BB Duncan","year":"2003","unstructured":"Duncan BB, Schmidt MI, Pankow JS et al (2003) Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes 52:1799\u20131805. https:\/\/doi.org\/10.2337\/diabetes.52.7.1799","journal-title":"Diabetes"},{"key":"8941_CR31","doi-asserted-by":"publisher","unstructured":"Rahman MM, Cibere J, Anis AH et al (2014)\u00a0Risk of type 2 diabetes among osteoarthritis patients in a prospective longitudinal study. Int J Rheumatol 2014.\u00a0https:\/\/doi.org\/10.1155\/2014\/620920","DOI":"10.1155\/2014\/620920"},{"key":"8941_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.rdc.2012.10.004","volume":"39","author":"T Neogi","year":"2013","unstructured":"Neogi T, Zhang Y (2013) Epidemiology of osteoarthritis. Rheum Dis Clin North Am 39:1\u201319","journal-title":"Rheum Dis Clin North Am"},{"key":"8941_CR33","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1016\/j.joca.2013.07.004","volume":"21","author":"R Agricola","year":"2013","unstructured":"Agricola R, Heijboer MP, Roze RH et al (2013) Pincer deformity does not lead to osteoarthritis of the hip whereas acetabular dysplasia does: acetabular coverage and development of osteoarthritis in a nationwide prospective cohort study (CHECK). Osteoarthr Cartil 21:1514\u20131521. https:\/\/doi.org\/10.1016\/j.joca.2013.07.004","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR34","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/NRRHEUM.2010.191","volume":"7","author":"AM Valdes","year":"2011","unstructured":"Valdes AM, Spector TD (2011) Genetic epidemiology of hip and knee osteoarthritis. Nat Rev Rheumatol 7:23\u201332. https:\/\/doi.org\/10.1038\/NRRHEUM.2010.191","journal-title":"Nat Rev Rheumatol"},{"key":"8941_CR35","doi-asserted-by":"publisher","unstructured":"Loughlin J (2005)\u00a0The genetic epidemiology of human primary osteoarthritis: current status. Expert Rev Mol Med 7.\u00a0https:\/\/doi.org\/10.1017\/S1462399405009257","DOI":"10.1017\/S1462399405009257"},{"key":"8941_CR36","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/S0140-6736(12)60681-3","volume":"380","author":"E Zeggini","year":"2012","unstructured":"Zeggini E, Panoutsopoulou K, Southam L et al (2012) Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet 380:815\u2013823. https:\/\/doi.org\/10.1016\/S0140-6736(12)60681-3","journal-title":"Lancet"},{"key":"8941_CR37","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1097\/BOR.0000000000000352","volume":"29","author":"SC Warnera","year":"2017","unstructured":"Warnera SC, Valdesa AM (2017) Genetic association studies in osteoarthritis: is it fairytale? Curr Opin Rheumatol 29:103\u2013109","journal-title":"Curr Opin Rheumatol"},{"key":"8941_CR38","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1097\/BOR.0b013e32835cfb8e","volume":"25","author":"MC Hochberg","year":"2013","unstructured":"Hochberg MC, Yerges-Armstrong L, Yau M, Mitchell BD (2013) Genetic epidemiology of osteoarthritis: recent developments and future directions. Curr Opin Rheumatol 25:192\u2013197","journal-title":"Curr Opin Rheumatol"},{"key":"8941_CR39","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1016\/J.JOCA.2015.01.003","volume":"23","author":"EL Rogers","year":"2015","unstructured":"Rogers EL, Reynard LN, Loughlin J (2015) The role of inflammation-related genes in osteoarthritis. Osteoarthr Cartil 23:1933\u20131938. https:\/\/doi.org\/10.1016\/J.JOCA.2015.01.003","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR40","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/NRRHEUM.2013.121","volume":"9","author":"LN Reynard","year":"2013","unstructured":"Reynard LN, Loughlin J (2013) Insights from human genetic studies into the pathways involved in osteoarthritis. Nat Rev Rheumatol 9:573\u2013583. https:\/\/doi.org\/10.1038\/NRRHEUM.2013.121","journal-title":"Nat Rev Rheumatol"},{"key":"8941_CR41","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/J.MOLMED.2011.11.005","volume":"18","author":"MB Goldring","year":"2012","unstructured":"Goldring MB, Marcu KB (2012) Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis. Trends Mol Med 18:109\u2013118. https:\/\/doi.org\/10.1016\/J.MOLMED.2011.11.005","journal-title":"Trends Mol Med"},{"key":"8941_CR42","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/J.JOCA.2011.12.012","volume":"20","author":"MJ Barter","year":"2012","unstructured":"Barter MJ, Bui C, Young DA (2012) Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs. Osteoarthr Cartil 20:339\u2013349. https:\/\/doi.org\/10.1016\/J.JOCA.2011.12.012","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR43","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/NRRHEUM.2014.189","volume":"11","author":"J Loughlin","year":"2015","unstructured":"Loughlin J, Reynard LN (2015) Osteoarthritis: epigenetics of articular cartilage in knee and hip OA. Nat Rev Rheumatol 11:6\u20137. https:\/\/doi.org\/10.1038\/NRRHEUM.2014.189","journal-title":"Nat Rev Rheumatol"},{"key":"8941_CR44","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1080\/03008207.2016.1208655","volume":"58","author":"J Shen","year":"2017","unstructured":"Shen J, Abu-Amer Y, O\u2019Keefe RJ, McAlinden A (2017) Inflammation and epigenetic regulation in osteoarthritis. Connect Tissue Res 58:49\u201363. https:\/\/doi.org\/10.1080\/03008207.2016.1208655","journal-title":"Connect Tissue Res"},{"key":"8941_CR45","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/J.PHARMTHERA.2018.11.001","volume":"195","author":"A Unnikrishnan","year":"2019","unstructured":"Unnikrishnan A, Freeman WM, Jackson J et al (2019) The role of DNA methylation in epigenetics of aging. Pharmacol Ther 195:172\u2013185. https:\/\/doi.org\/10.1016\/J.PHARMTHERA.2018.11.001","journal-title":"Pharmacol Ther"},{"key":"8941_CR46","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1097\/BOR.0000000000000161","volume":"27","author":"KD Allen","year":"2015","unstructured":"Allen KD, Golightly YM (2015) State of the evidence. Curr Opin Rheumatol 27:276\u2013283","journal-title":"Curr Opin Rheumatol"},{"key":"8941_CR47","doi-asserted-by":"crossref","unstructured":"Glyn-Jones S, Palmer AJR, Agricola R et al (2015) Osteoarthritis. In: The Lancet. Lancet Publishing Group, pp 376\u2013387","DOI":"10.1016\/S0140-6736(14)60802-3"},{"key":"8941_CR48","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/nrrheum.2013.114","volume":"9","author":"R Agricola","year":"2013","unstructured":"Agricola R, Waarsing JH, Arden NK et al (2013) Cam impingement of the hip-a risk factor for hip osteoarthritis. Nat Rev Rheumatol 9:630\u2013634","journal-title":"Nat Rev Rheumatol"},{"key":"8941_CR49","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1002\/art.37987","volume":"65","author":"T Neogi","year":"2013","unstructured":"Neogi T, Bowes MA, Niu J et al (2013) Magnetic resonance imaging-based three-dimensional bone shape of the knee predicts onset of knee osteoarthritis: data from the osteoarthritis initiative. Arthritis Rheum 65:2048\u20132058. https:\/\/doi.org\/10.1002\/art.37987","journal-title":"Arthritis Rheum"},{"key":"8941_CR50","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1136\/annrheumdis-2011-201070","volume":"72","author":"L Sharma","year":"2013","unstructured":"Sharma L, Chmiel JS, Almagor O et al (2013) The role of varus and valgus alignment in the initial development of knee cartilage damage by MRI: the MOST study. Ann Rheum Dis 72:235\u2013240. https:\/\/doi.org\/10.1136\/annrheumdis-2011-201070","journal-title":"Ann Rheum Dis"},{"key":"8941_CR51","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1002\/art.37726","volume":"65","author":"DT Felson","year":"2013","unstructured":"Felson DT, Niu J, Gross KD et al (2013) Valgus malalignment is a risk factor for lateral knee osteoarthritis incidence and progression: findings from the multicenter osteoarthritis study and the osteoarthritis initiative. Arthritis Rheum 65:355\u2013362. https:\/\/doi.org\/10.1002\/art.37726","journal-title":"Arthritis Rheum"},{"key":"8941_CR52","doi-asserted-by":"publisher","first-page":"287","DOI":"10.7326\/0003-4819-152-5-201003020-00006","volume":"152","author":"WF Harvey","year":"2010","unstructured":"Harvey WF, Yang M, Cooke TDV et al (2010) Association of leg-length inequality with knee osteoarthritis a cohort study. Ann Intern Med 152:287\u2013295. https:\/\/doi.org\/10.7326\/0003-4819-152-5-201003020-00006","journal-title":"Ann Intern Med"},{"key":"8941_CR53","doi-asserted-by":"publisher","first-page":"3917","DOI":"10.1002\/art.34681","volume":"64","author":"Y Wang","year":"2012","unstructured":"Wang Y, Wluka AE, Berry PA et al (2012) Increase in vastus medialis cross-sectional area is associated with reduced pain, cartilage loss, and joint replacement risk in knee osteoarthritis. Arthritis Rheum 64:3917\u20133925. https:\/\/doi.org\/10.1002\/art.34681","journal-title":"Arthritis Rheum"},{"key":"8941_CR54","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/art.11012","volume":"49","author":"AM Lievense","year":"2003","unstructured":"Lievense AM, Bierma-Zeinstra SMA, Verhagen AP et al (2003) Influence of sporting activities on the development of osteoarthritis of the hip: a systematic review. Arthritis Care Res 49:228\u2013236","journal-title":"Arthritis Care Res"},{"key":"8941_CR55","doi-asserted-by":"publisher","first-page":"2308","DOI":"10.1177\/0363546513497564","volume":"41","author":"KA Siebenrock","year":"2013","unstructured":"Siebenrock KA, Kaschka I, Frauchiger L et al (2013) Prevalence of cam-type deformity and hip pain in elite ice hockey players before and after the end of growth. Am J Sports Med 41:2308\u20132313. https:\/\/doi.org\/10.1177\/0363546513497564","journal-title":"Am J Sports Med"},{"key":"8941_CR56","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1136\/ard.2008.099531","volume":"69","author":"MC Nevitt","year":"2010","unstructured":"Nevitt MC, Zhang Y, Javaid MK et al (2010) High systemic bone mineral density increases the risk of incident knee OA and joint space narrowing, but not radiographic progression of existing knee OA: The MOST study. Ann Rheum Dis 69:163\u2013168. https:\/\/doi.org\/10.1136\/ard.2008.099531","journal-title":"Ann Rheum Dis"},{"key":"8941_CR57","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1016\/j.joca.2011.07.015","volume":"19","author":"SG Muthuri","year":"2011","unstructured":"Muthuri SG, McWilliams DF, Doherty M, Zhang W (2011) History of knee injuries and knee osteoarthritis: a meta-analysis of observational studies. Osteoarthr Cartil 19:1286\u20131293. https:\/\/doi.org\/10.1016\/j.joca.2011.07.015","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR58","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.joca.2009.08.010","volume":"18","author":"M Blagojevic","year":"2010","unstructured":"Blagojevic M, Jinks C, Jeffery A, Jordan KP (2010) Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthr Cartil 18:24\u201333. https:\/\/doi.org\/10.1016\/j.joca.2009.08.010","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/203901","volume":"2011","author":"J Conde","year":"2011","unstructured":"Conde J, Scotece M, G\u00f3mez R et al (2011) Adipokines and osteoarthritis: novel molecules involved in the pathogenesis and progression of disease. Arthritis 2011:1\u20138. https:\/\/doi.org\/10.1155\/2011\/203901","journal-title":"Arthritis"},{"key":"8941_CR60","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1002\/art.39707","volume":"68","author":"C Reyes","year":"2016","unstructured":"Reyes C, Leyland KM, Peat G et al (2016) Association between overweight and obesity and risk of clinically diagnosed knee, hip, and hand osteoarthritis: a population-based cohort study. Arthritis Rheumatol 68:1869\u20131875. https:\/\/doi.org\/10.1002\/art.39707","journal-title":"Arthritis Rheumatol"},{"key":"8941_CR61","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1148\/radiol.2017161005","volume":"284","author":"AS Gersing","year":"2017","unstructured":"Gersing AS, Schwaiger BJ, Nevitt MC et al (2017) Is weight loss associated with less progression of changes in knee articular cartilage among obese and overweight patients as assessed with MR imaging over 48 months? Data from the osteoarthritis initiative. Radiology 284:508\u2013520. https:\/\/doi.org\/10.1148\/radiol.2017161005","journal-title":"Radiology"},{"key":"8941_CR62","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1002\/acr.22805","volume":"68","author":"I Atukorala","year":"2016","unstructured":"Atukorala I, Makovey J, Lawler L et al (2016) Is there a dose-response relationship between weight loss and symptom improvement in persons with knee osteoarthritis? Arthritis Care Res 68:1106\u20131114. https:\/\/doi.org\/10.1002\/acr.22805","journal-title":"Arthritis Care Res"},{"key":"8941_CR63","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1016\/j.joca.2017.01.014","volume":"25","author":"N Frey","year":"2017","unstructured":"Frey N, H\u00fcgle T, Jick SS et al (2017) Hyperlipidaemia and incident osteoarthritis of the hand: a population-based case-control study. Osteoarthr Cartil 25:1040\u20131045. https:\/\/doi.org\/10.1016\/j.joca.2017.01.014","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR64","doi-asserted-by":"publisher","unstructured":"Garcia-Gil M, Reyes C, Ramos R et al (2017)\u00a0Serum lipid levels and risk of hand osteoarthritis: the Chingford prospective cohort study. Sci Rep 7.\u00a0https:\/\/doi.org\/10.1038\/s41598-017-03317-4","DOI":"10.1038\/s41598-017-03317-4"},{"key":"8941_CR65","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1177\/1759720X16664323","volume":"8","author":"JB Driban","year":"2016","unstructured":"Driban JB, Lo GH, Eaton CB et al (2016) Exploratory analysis of osteoarthritis progression among medication users: data from the Osteoarthritis Initiative. Ther Adv Musculoskelet Dis 8:207\u2013219. https:\/\/doi.org\/10.1177\/1759720X16664323","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"8941_CR66","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1007\/s10067-017-3656-z","volume":"36","author":"GH Lo","year":"2017","unstructured":"Lo GH, McAlindon TE, Katz JN et al (2017) Systolic and pulse pressure associate with incident knee osteoarthritis: data from the Osteoarthritis Initiative. Clin Rheumatol 36:2121\u20132128. https:\/\/doi.org\/10.1007\/s10067-017-3656-z","journal-title":"Clin Rheumatol"},{"key":"8941_CR67","doi-asserted-by":"publisher","unstructured":"Magnusson K, Bech Holte K, Juel NG et al (2017)\u00a0Long term type 1 diabetes is associated with hand pain, disability and stiffness but not with structural hand osteoarthritis features - The Dialong hand study. PLoS ONE 12.\u00a0https:\/\/doi.org\/10.1371\/journal.pone.0177118","DOI":"10.1371\/journal.pone.0177118"},{"key":"8941_CR68","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1016\/j.joca.2016.04.005","volume":"24","author":"N Frey","year":"2016","unstructured":"Frey N, H\u00fcgle T, Jick SS et al (2016) Type II diabetes mellitus and incident osteoarthritis of the hand: a population-based case\u2013control analysis. Osteoarthr Cartil 24:1535\u20131540. https:\/\/doi.org\/10.1016\/j.joca.2016.04.005","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR69","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1016\/j.joca.2016.04.007","volume":"24","author":"EDG Garessus","year":"2016","unstructured":"Garessus EDG, de Mutsert R, Visser AW et al (2016) No association between impaired glucose metabolism and osteoarthritis. Osteoarthr Cartil 24:1541\u20131547. https:\/\/doi.org\/10.1016\/j.joca.2016.04.007","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR70","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1016\/j.joca.2017.02.804","volume":"25","author":"X Wang","year":"2017","unstructured":"Wang X, Cicuttini F, Jin X et al (2017) Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis. Osteoarthr Cartil 25:1304\u20131312. https:\/\/doi.org\/10.1016\/j.joca.2017.02.804","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR71","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.joca.2012.11.012","volume":"21","author":"F Berenbaum","year":"2013","unstructured":"Berenbaum F (2013) Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthr Cartil 21:16\u201321","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR72","doi-asserted-by":"publisher","first-page":"26035","DOI":"10.3390\/ijms161125943","volume":"16","author":"HS Hwang","year":"2015","unstructured":"Hwang HS, Kim HA (2015) Chondrocyte apoptosis in the pathogenesis of osteoarthritis. Int J Mol Sci 16:26035\u201326054","journal-title":"Int J Mol Sci"},{"key":"8941_CR73","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.matbio.2018.05.008","volume":"71\u201372","author":"F Guilak","year":"2018","unstructured":"Guilak F, Nims RJ, Dicks A et al (2018) Osteoarthritis as a disease of the cartilage pericellular matrix. Matrix Biol 71\u201372:40\u201350","journal-title":"Matrix Biol"},{"key":"8941_CR74","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1097\/BOR.0000000000000181","volume":"27","author":"T Funck-Brentano","year":"2015","unstructured":"Funck-Brentano T, Cohen-Solal M (2015) Subchondral bone and osteoarthritis. Curr Opin Rheumatol 27:420\u2013426","journal-title":"Curr Opin Rheumatol"},{"key":"8941_CR75","doi-asserted-by":"crossref","unstructured":"Kov\u00e1cs B, Vajda E, Nagy EE (2019) Regulatory effects and interactions of the Wnt and OPG-RANKL-RANK signaling at the bone-cartilage interface in osteoarthritis. Int J Mol Sci 20","DOI":"10.3390\/ijms20184653"},{"key":"8941_CR76","doi-asserted-by":"crossref","unstructured":"Zhou X, Cao H, Yuan Y, Wu W (2020) Biochemical signals mediate the crosstalk between cartilage and bone in osteoarthritis. Biomed Res Int\u00a02020","DOI":"10.1155\/2020\/5720360"},{"key":"8941_CR77","doi-asserted-by":"crossref","unstructured":"Mathiessen A, Conaghan PG (2017) Synovitis in osteoarthritis: current understanding with therapeutic implications. Arthritis Res Ther 19","DOI":"10.1186\/s13075-017-1229-9"},{"key":"8941_CR78","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1016\/j.joca.2016.03.004","volume":"24","author":"A Sarmanova","year":"2016","unstructured":"Sarmanova A, Hall M, Moses J et al (2016) Synovial changes detected by ultrasound in people with knee osteoarthritis \u2013 a meta-analysis of observational studies. Osteoarthr Cartil 24:1376\u20131383. https:\/\/doi.org\/10.1016\/j.joca.2016.03.004","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR79","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3899\/jrheum.130541","volume":"41","author":"A Guermazi","year":"2014","unstructured":"Guermazi A, Hayashi D, Roemer FW et al (2014) Synovitis in knee osteoarthritis assessed by contrast-enhanced magnetic resonance imaging (MRI) is associated with radiographic tibiofemoral osteoarthritis and MRI-detected widespread cartilage damage: The MOST study. J Rheumatol 41:501\u2013508. https:\/\/doi.org\/10.3899\/jrheum.130541","journal-title":"J Rheumatol"},{"key":"8941_CR80","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.joca.2015.09.013","volume":"24","author":"DT Felson","year":"2016","unstructured":"Felson DT, Niu J, Neogi T et al (2016) Synovitis and the risk of knee osteoarthritis: the MOST study. Osteoarthr Cartil 24:458\u2013464. https:\/\/doi.org\/10.1016\/j.joca.2015.09.013","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR81","doi-asserted-by":"publisher","unstructured":"Prieto-Potin I, Largo R, Roman-Blas JA et al (2015)\u00a0Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis. BMC Musculoskelet Disord 16.\u00a0https:\/\/doi.org\/10.1186\/s12891-015-0664-5","DOI":"10.1186\/s12891-015-0664-5"},{"key":"8941_CR82","doi-asserted-by":"crossref","unstructured":"Wojdasiewicz P, Poniatowski \u0141A, Szukiewicz D (2014) The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediators Inflamm\u00a02014","DOI":"10.1155\/2014\/561459"},{"key":"8941_CR83","doi-asserted-by":"publisher","first-page":"771","DOI":"10.3899\/jrheum.151068","volume":"43","author":"IR Klein-Wieringa","year":"2016","unstructured":"Klein-Wieringa IR, De Lange-Brokaar BJE, Yusuf E et al (2016) Inflammatory cells in patients with endstage knee osteoarthritis: a comparison between the synovium and the infrapatellar fat pad. J Rheumatol 43:771\u2013778. https:\/\/doi.org\/10.3899\/jrheum.151068","journal-title":"J Rheumatol"},{"key":"8941_CR84","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","volume":"7","author":"M Kapoor","year":"2011","unstructured":"Kapoor M, Martel-Pelletier J, Lajeunesse D et al (2011) Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol 7:33\u201342","journal-title":"Nat Rev Rheumatol"},{"key":"8941_CR85","doi-asserted-by":"publisher","unstructured":"Cai S, Ming B, Ye C et al (2021)\u00a0Similar transition processes in synovial fibroblasts from rheumatoid arthritis and osteoarthritis: a single-cell study. Clin Dev Immunol 2019. https:\/\/doi.org\/10.1155\/2019\/4080735","DOI":"10.1155\/2019\/4080735"},{"key":"8941_CR86","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1136\/annrheumdis-2013-204494","volume":"74","author":"X Jin","year":"2015","unstructured":"Jin X, Beguerie JR, Zhang W et al (2015) Circulating C reactive protein in osteoarthritis: a systematic review and meta-analysis. Ann Rheum Dis 74:703\u2013710. https:\/\/doi.org\/10.1136\/annrheumdis-2013-204494","journal-title":"Ann Rheum Dis"},{"key":"8941_CR87","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1016\/j.joca.2010.08.016","volume":"18","author":"O Stannus","year":"2010","unstructured":"Stannus O, Jones G, Cicuttini F et al (2010) Circulating levels of IL-6 and TNF-\u03b1 are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults. Osteoarthr Cartil 18:1441\u20131447. https:\/\/doi.org\/10.1016\/j.joca.2010.08.016","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR88","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1002\/art.24598","volume":"60","author":"G Livshits","year":"2009","unstructured":"Livshits G, Zhai G, Hart DJ et al (2009) Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: the Chingford study. Arthritis Rheum 60:2037\u20132045. https:\/\/doi.org\/10.1002\/art.24598","journal-title":"Arthritis Rheum"},{"key":"8941_CR89","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1002\/art.1780400419","volume":"40","author":"TD Spector","year":"1997","unstructured":"Spector TD, Hart DJ, Nandra D et al (1997) Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease. Arthritis Rheum 40:723\u2013727. https:\/\/doi.org\/10.1002\/art.1780400419","journal-title":"Arthritis Rheum"},{"key":"8941_CR90","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1017\/S1368980007000663","volume":"10","author":"M Bull\u00f3","year":"2007","unstructured":"Bull\u00f3 M, Casas-Agustench P, Amig\u00f3-Correig P et al (2007) Inflammation, obesity and comorbidities: the role of diet. Public Health Nutr 10:1164\u20131172","journal-title":"Public Health Nutr"},{"key":"8941_CR91","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.joca.2006.01.009","volume":"14","author":"N Presle","year":"2006","unstructured":"Presle N, Pottie P, Dumond H et al (2006) Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular production. Osteoarthr Cartil 14:690\u2013695. https:\/\/doi.org\/10.1016\/j.joca.2006.01.009","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR92","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1016\/j.joca.2012.05.002","volume":"20","author":"TN de Boer","year":"2012","unstructured":"de Boer TN, van Spil WE, Huisman AM et al (2012) Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage. Osteoarthr Cartil 20:846\u2013853. https:\/\/doi.org\/10.1016\/j.joca.2012.05.002","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR93","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1080\/03008207.2019.1620221","volume":"60","author":"B Liu","year":"2019","unstructured":"Liu B, Gao YH, Dong N et al (2019) Differential expression of adipokines in the synovium and infrapatellar fat pad of osteoarthritis patients with and without metabolic syndrome. Connect Tissue Res 60:611\u2013618. https:\/\/doi.org\/10.1080\/03008207.2019.1620221","journal-title":"Connect Tissue Res"},{"key":"8941_CR94","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cyto.2018.06.019","volume":"113","author":"C Tu","year":"2019","unstructured":"Tu C, He J, Wu B et al (2019) An extensive review regarding the adipokines in the pathogenesis and progression of osteoarthritis. Cytokine 113:1\u201312","journal-title":"Cytokine"},{"key":"8941_CR95","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/nrrheum.2016.49","volume":"12","author":"E Neumann","year":"2016","unstructured":"Neumann E, Junker S, Schett G et al (2016) Adipokines in bone disease. Nat Rev Rheumatol 12:296\u2013302","journal-title":"Nat Rev Rheumatol"},{"key":"8941_CR96","doi-asserted-by":"crossref","unstructured":"Zhao CW, Gao YH, Song WX et al (2019) An update on the emerging role of resistin on the pathogenesis of osteoarthritis. Mediators Inflamm\u00a02019","DOI":"10.1155\/2019\/1532164"},{"key":"8941_CR97","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/NRENDO.2015.117","volume":"11","author":"A Garten","year":"2015","unstructured":"Garten A, Schuster S, Penke M et al (2015) Physiological and pathophysiological roles of NAMPT and NAD metabolism. Nat Rev Endocrinol 11:535\u2013546. https:\/\/doi.org\/10.1038\/NRENDO.2015.117","journal-title":"Nat Rev Endocrinol"},{"key":"8941_CR98","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1158\/0008-5472.CAN-18-1544","volume":"79","author":"C Travelli","year":"2019","unstructured":"Travelli C, Consonni FM, Sangaletti S et al (2019) Nicotinamide phosphoribosyltransferase acts as a metabolic gate for mobilization of myeloid-derived suppressor cells. Cancer Res 79:1938\u20131951. https:\/\/doi.org\/10.1158\/0008-5472.CAN-18-1544","journal-title":"Cancer Res"},{"key":"8941_CR99","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/J.CANLET.2017.12.035","volume":"418","author":"Q Yu","year":"2018","unstructured":"Yu Q, Dong L, Li Y, Liu G (2018) SIRT1 and HIF1\u03b1 signaling in metabolism and immune responses. Cancer Lett 418:20\u201326. https:\/\/doi.org\/10.1016\/J.CANLET.2017.12.035","journal-title":"Cancer Lett"},{"key":"8941_CR100","doi-asserted-by":"publisher","unstructured":"Dvir-Ginzberg M, Steinmeyer J (2013) Towards elucidating the role of SirT1 in osteoarthritis. Front Biosci (Landmark Ed) 18:343\u2013355. https:\/\/doi.org\/10.2741\/4105","DOI":"10.2741\/4105"},{"key":"8941_CR101","doi-asserted-by":"publisher","unstructured":"Chen C, Zhou M, Ge Y, Wang X (2020)\u00a0SIRT1 and aging related signaling pathways. Mech Ageing Dev 187.\u00a0https:\/\/doi.org\/10.1016\/J.MAD.2020.111215","DOI":"10.1016\/J.MAD.2020.111215"},{"key":"8941_CR102","doi-asserted-by":"publisher","unstructured":"Tsai CH, Liu SC, Chung WH et al (2020)\u00a0Visfatin increases VEGF-dependent angiogenesis of endothelial progenitor cells during osteoarthritis progression. Cells 9.\u00a0https:\/\/doi.org\/10.3390\/CELLS9051315","DOI":"10.3390\/CELLS9051315"},{"key":"8941_CR103","doi-asserted-by":"publisher","unstructured":"Suzuki A, Yabu A, Nakamura H (2020) Advanced glycation end products in musculoskeletal system and disorders. Methods 203:179\u2013186. https:\/\/doi.org\/10.1016\/j.ymeth.2020.09.012","DOI":"10.1016\/j.ymeth.2020.09.012"},{"key":"8941_CR104","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1016\/j.cellsig.2013.06.013","volume":"25","author":"J Xie","year":"2013","unstructured":"Xie J, M\u00e9ndez JD, M\u00e9ndez-Valenzuela V, Aguilar-Hern\u00e1ndez MM (2013) Cellular signalling of the receptor for advanced glycation end products (RAGE). Cell Signal 25:2185\u20132197","journal-title":"Cell Signal"},{"key":"8941_CR105","doi-asserted-by":"crossref","unstructured":"Lambert C, Zappia J, Sanchez C et al (2021) The damage-associated molecular patterns (DAMPs) as potential targets to treat osteoarthritis: perspectives from a review of the literature. Front Med 7","DOI":"10.3389\/fmed.2020.607186"},{"key":"8941_CR106","doi-asserted-by":"crossref","unstructured":"Motta F, Sica A, Selmi C (2020) Frailty in rheumatic diseases. Front Immunol 11","DOI":"10.3389\/fimmu.2020.576134"},{"key":"8941_CR107","doi-asserted-by":"publisher","DOI":"10.1007\/S12016-021-08899-6","author":"T Fulop","year":"2021","unstructured":"Fulop T, Larbi A, Pawelec G et al (2021) Immunology of aging: the birth of inflammaging. Clin Rev Allergy Immunol. https:\/\/doi.org\/10.1007\/S12016-021-08899-6","journal-title":"Clin Rev Allergy Immunol"},{"key":"8941_CR108","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1093\/gerona\/glu057","volume":"69","author":"C Franceschi","year":"2014","unstructured":"Franceschi C, Campisi J (2014) Chronic inflammation (Inflammaging) and its potential contribution to age-associated diseases. J Gerontol - Ser A Biol Sci Med Sci 69:S4\u2013S9","journal-title":"J Gerontol - Ser A Biol Sci Med Sci"},{"key":"8941_CR109","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3322\/caac.21262","volume":"65","author":"LA Torre","year":"2015","unstructured":"Torre LA, Bray F, Siegel RL et al (2015) Global cancer statistics, 2012. CA Cancer J Clin 65:87\u2013108. https:\/\/doi.org\/10.3322\/caac.21262","journal-title":"CA Cancer J Clin"},{"key":"8941_CR110","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.cell.2014.10.039","volume":"159","author":"BK Kennedy","year":"2014","unstructured":"Kennedy BK, Berger SL, Brunet A et al (2014) Geroscience: linking aging to chronic disease. Cell 159:709\u2013713","journal-title":"Cell"},{"key":"8941_CR111","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","volume":"153","author":"C L\u00f3pez-Ot\u00edn","year":"2013","unstructured":"L\u00f3pez-Ot\u00edn C, Blasco MA, Partridge L et al (2013) The hallmarks of aging. Cell 153:1194","journal-title":"Cell"},{"key":"8941_CR112","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/35041687","volume":"408","author":"T Finkel","year":"2000","unstructured":"Finkel T, Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408:239\u2013247","journal-title":"Nature"},{"key":"8941_CR113","first-page":"1603","volume":"49","author":"S Reuter","year":"2010","unstructured":"Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB (2010) Oxidative stress, inflammation, and cancer: how are they linked? Free Radic. Biol Med 49:1603\u20131616","journal-title":"Biol Med"},{"key":"8941_CR114","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.arr.2012.10.004","volume":"12","author":"V Sosa","year":"2013","unstructured":"Sosa V, Molin\u00e9 T, Somoza R et al (2013) Oxidative stress and cancer: an overview. Ageing Res Rev 12:376\u2013390","journal-title":"Ageing Res Rev"},{"key":"8941_CR115","doi-asserted-by":"publisher","first-page":"106","DOI":"10.4093\/dmj.2013.37.2.106","volume":"37","author":"U Karunakaran","year":"2013","unstructured":"Karunakaran U, Park KG (2013) A systematic review of oxidative stress and safety of antioxidants in diabetes: focus on islets and their defense. Diabetes Metab J 37:106\u2013112","journal-title":"Diabetes Metab J"},{"key":"8941_CR116","doi-asserted-by":"crossref","unstructured":"Pirillo A, Norata GD, Catapano AL (2013) LOX-1, OxLDL, and atherosclerosis. Mediators Inflamm. 2013","DOI":"10.1155\/2013\/152786"},{"key":"8941_CR117","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.bbrc.2019.03.130","volume":"512","author":"W Yu","year":"2019","unstructured":"Yu W, Zhang H, Shin MR, Sesti F (2019) Oxidation of KCNB1 potassium channels in the murine brain during aging is associated with cognitive impairment. Biochem Biophys Res Commun 512:665\u2013669. https:\/\/doi.org\/10.1016\/j.bbrc.2019.03.130","journal-title":"Biochem Biophys Res Commun"},{"key":"8941_CR118","doi-asserted-by":"crossref","unstructured":"Liu Z, Zhou T, Ziegler AC et al (2017) Oxidative stress in neurodegenerative diseases: from molecular mechanisms to clinical applications. Oxid Med Cell Longev\u00a02017","DOI":"10.1155\/2017\/2525967"},{"key":"8941_CR119","doi-asserted-by":"publisher","unstructured":"John-Schuster G, G\u00fcnter S, Hager K et al (2016) Inflammaging increases susceptibility to cigarette smoke-induced COPD. Oncotarget 7:30068\u201330083. https:\/\/doi.org\/10.18632\/oncotarget.4027","DOI":"10.18632\/oncotarget.4027"},{"key":"8941_CR120","doi-asserted-by":"publisher","unstructured":"Mateen S, Moin S, Khan AQ et al (2016)\u00a0Increased reactive oxygen species formation and oxidative stress in rheumatoid arthritis. PLoS ONE 11.\u00a0https:\/\/doi.org\/10.1371\/journal.pone.0152925","DOI":"10.1371\/journal.pone.0152925"},{"key":"8941_CR121","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.exger.2017.10.027","volume":"105","author":"Y Li","year":"2018","unstructured":"Li Y, Goronzy JJ, Weyand CM (2018) DNA damage, metabolism and aging in pro-inflammatory T cells: Rheumatoid arthritis as a model system. Exp Gerontol 105:118\u2013127","journal-title":"Exp Gerontol"},{"key":"8941_CR122","doi-asserted-by":"crossref","unstructured":"Franceschi C, Bonaf\u00e8 M, Valensin S et al (2000) Inflammaging. An evolutionary perspective on immunosenescence. In: Annals of the New York Academy of Sciences. New York Academy of Sciences, pp 244\u2013254","DOI":"10.1111\/j.1749-6632.2000.tb06651.x"},{"key":"8941_CR123","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/nrendo.2013.29","volume":"9","author":"G Vitale","year":"2013","unstructured":"Vitale G, Salvioli S, Franceschi C (2013) Oxidative stress and the ageing endocrine system. Nat Rev Endocrinol 9:228\u2013240","journal-title":"Nat Rev Endocrinol"},{"key":"8941_CR124","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.smim.2018.09.003","volume":"40","author":"T Fulop","year":"2018","unstructured":"Fulop T, Witkowski JM, Olivieri F, Larbi A (2018) The integration of inflammaging in age-related diseases. Semin Immunol 40:17\u201335","journal-title":"Semin Immunol"},{"key":"8941_CR125","doi-asserted-by":"publisher","unstructured":"Callender LA, Carroll EC, Beal RWJ et al (2018)\u00a0Human CD8 + EMRA T cells display a senescence-associated secretory phenotype regulated by p38 MAPK. Aging Cell 17.\u00a0https:\/\/doi.org\/10.1111\/acel.12675","DOI":"10.1111\/acel.12675"},{"key":"8941_CR126","doi-asserted-by":"publisher","unstructured":"Copp\u00e9 JP, Patil CK, Rodier F et al (2008)\u00a0Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 6.\u00a0https:\/\/doi.org\/10.1371\/journal.pbio.0060301","DOI":"10.1371\/journal.pbio.0060301"},{"key":"8941_CR127","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","volume":"5","author":"JP Copp\u00e9","year":"2010","unstructured":"Copp\u00e9 JP, Desprez PY, Krtolica A, Campisi J (2010) The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol Mech Dis 5:99\u2013118","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"8941_CR128","doi-asserted-by":"publisher","DOI":"10.1007\/S12016-021-08909-7","author":"A Bleve","year":"2022","unstructured":"Bleve A, Motta F, Durante B et al (2022) Immunosenescence, inflammaging, and frailty: role of myeloid cells in age-related diseases. Clin Rev Allergy Immunol. https:\/\/doi.org\/10.1007\/S12016-021-08909-7","journal-title":"Clin Rev Allergy Immunol"},{"key":"8941_CR129","doi-asserted-by":"publisher","first-page":"5825","DOI":"10.4049\/jimmunol.1500082","volume":"194","author":"BD Coder","year":"2015","unstructured":"Coder BD, Wang H, Ruan L, Su D-M (2015) Thymic involution perturbs negative selection leading to autoreactive t cells that induce chronic inflammation. J Immunol 194:5825\u20135837. https:\/\/doi.org\/10.4049\/jimmunol.1500082","journal-title":"J Immunol"},{"key":"8941_CR130","doi-asserted-by":"publisher","first-page":"21777","DOI":"10.18632\/oncotarget.4970","volume":"6","author":"B Coder","year":"2015","unstructured":"Coder B, Su DM (2015) Thymic involution beyond T-cell insufficiency. Oncotarget 6:21777\u201321778","journal-title":"Oncotarget"},{"key":"8941_CR131","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.arr.2010.08.003","volume":"10","author":"S Brunner","year":"2011","unstructured":"Brunner S, Herndler-Brandstetter D, Weinberger B, Grubeck-Loebenstein B (2011) Persistent viral infections and immune aging. Ageing Res Rev 10:362\u2013369","journal-title":"Ageing Res Rev"},{"key":"8941_CR132","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/prd.12135","volume":"72","author":"JL Ebersole","year":"2000","unstructured":"Ebersole JL, Graves CL, Gonzalez OA et al (2000) (2016) Aging, inflammation, immunity and periodontal disease. Periodontol 72:54\u201375","journal-title":"Periodontol"},{"key":"8941_CR133","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.tem.2016.09.005","volume":"28","author":"C Franceschi","year":"2017","unstructured":"Franceschi C, Garagnani P, Vitale G et al (2017) Inflammaging and \u2018Garb-aging.\u2019 Trends Endocrinol Metab 28:199\u2013212","journal-title":"Trends Endocrinol Metab"},{"key":"8941_CR134","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.660901","volume":"12","author":"B-J Lee","year":"2021","unstructured":"Lee B-J, Min C-K, Hancock M et al (2021) Human cytomegalovirus host interactions: EGFR and host cell signaling is a point of convergence between viral infection and functional changes in infected cells. Front Microbiol 12:660901. https:\/\/doi.org\/10.3389\/fmicb.2021.660901","journal-title":"Front Microbiol"},{"key":"8941_CR135","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/0140-6736(90)92145-8","volume":"336","author":"JM Lohr","year":"1990","unstructured":"Lohr JM, Oldstone MBA (1990) Detection of cytomegalovirus nucleic acid sequences in pancreas in type 2 diabetes. Lancet 336:644\u2013648. https:\/\/doi.org\/10.1016\/0140-6736(90)92145-8","journal-title":"Lancet"},{"key":"8941_CR136","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/nri2925","volume":"11","author":"MY Donath","year":"2011","unstructured":"Donath MY, Shoelson SE (2011) Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 11:98\u2013107","journal-title":"Nat Rev Immunol"},{"key":"8941_CR137","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.celrep.2016.05.070","volume":"16","author":"H Low","year":"2016","unstructured":"Low H, Mukhamedova N, Cui HL et al (2016) Cytomegalovirus restructures lipid rafts via a US28\/CDC42-mediated pathway, enhancing cholesterol efflux from host cells. Cell Rep 16:186\u2013200. https:\/\/doi.org\/10.1016\/j.celrep.2016.05.070","journal-title":"Cell Rep"},{"key":"8941_CR138","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.tim.2011.04.002","volume":"19","author":"Y Yu","year":"2011","unstructured":"Yu Y, Clippinger AJ, Alwine JC (2011) Viral effects on metabolism: changes in glucose and glutamine utilization during human cytomegalovirus infection. Trends Microbiol 19:360\u2013367","journal-title":"Trends Microbiol"},{"key":"8941_CR139","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nature05485","volume":"444","author":"GS Hotamisligil","year":"2006","unstructured":"Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444:860\u2013867","journal-title":"Nature"},{"key":"8941_CR140","doi-asserted-by":"publisher","unstructured":"Ye J, Keller JN (2010) Regulation of energy metabolism by inflammation: a feedback response in obesity and calorie restriction. Aging (Albany NY) 2:361\u2013368. https:\/\/doi.org\/10.18632\/aging.100155","DOI":"10.18632\/aging.100155"},{"key":"8941_CR141","doi-asserted-by":"publisher","unstructured":"Collino S, Montoliu I, Martin F-PJ et al (2013)\u00a0Correction: metabolic signatures of extreme longevity in Northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism. PLoS ONE 8.\u00a0https:\/\/doi.org\/10.1371\/annotation\/5fb9fa6f-4889-4407-8430-6dfc7ecdfbdd","DOI":"10.1371\/annotation\/5fb9fa6f-4889-4407-8430-6dfc7ecdfbdd"},{"key":"8941_CR142","doi-asserted-by":"publisher","unstructured":"Biagi E, Nylund L, Candela M et al (2010)\u00a0Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS ONE 5.\u00a0https:\/\/doi.org\/10.1371\/journal.pone.0010667","DOI":"10.1371\/journal.pone.0010667"},{"key":"8941_CR143","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.arr.2011.03.004","volume":"10","author":"E Biagi","year":"2011","unstructured":"Biagi E, Candela M, Franceschi C, Brigidi P (2011) The aging gut microbiota: new perspectives. Ageing Res Rev 10:428\u2013429","journal-title":"Ageing Res Rev"},{"key":"8941_CR144","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1097\/MCO.0b013e32835ada13","volume":"16","author":"E Cevenini","year":"2013","unstructured":"Cevenini E, Monti D, Franceschi C (2013) Inflamm-ageing. Curr Opin Clin Nutr Metab Care 16:14\u201320","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"8941_CR145","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1016\/j.cub.2016.04.016","volume":"26","author":"E Biagi","year":"2016","unstructured":"Biagi E, Franceschi C, Rampelli S et al (2016) Gut microbiota and extreme longevity. Curr Biol 26:1480\u20131485. https:\/\/doi.org\/10.1016\/j.cub.2016.04.016","journal-title":"Curr Biol"},{"key":"8941_CR146","doi-asserted-by":"crossref","unstructured":"Franceschi C, Salvioli S, Garagnani P et al (2017) Immunobiography and the heterogeneity of immune responses in the elderly: a focus on inflammaging and trained immunity. Front Immunol 8","DOI":"10.3389\/fimmu.2017.00982"},{"key":"8941_CR147","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00018-017-2674-y","volume":"75","author":"A Santoro","year":"2018","unstructured":"Santoro A, Ostan R, Candela M et al (2018) Gut microbiota changes in the extreme decades of human life: a focus on centenarians. Cell Mol Life Sci 75:129\u2013148","journal-title":"Cell Mol Life Sci"},{"key":"8941_CR148","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1016\/j.cell.2017.11.024","volume":"171","author":"P Kundu","year":"2017","unstructured":"Kundu P, Blacher E, Elinav E, Pettersson S (2017) Our gut microbiome: the evolving inner self. Cell 171:1481\u20131493","journal-title":"Cell"},{"key":"8941_CR149","doi-asserted-by":"crossref","unstructured":"Lee C, Longo V (2016) Dietary restriction with and without caloric restriction for healthy aging. F1000Research 5","DOI":"10.12688\/f1000research.7136.1"},{"key":"8941_CR150","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.2337\/db11-1300","volume":"61","author":"N Barzilai","year":"2012","unstructured":"Barzilai N, Huffman DM, Muzumdar RH, Bartke A (2012) The critical role of metabolic pathways in aging. Diabetes 61:1315\u20131322","journal-title":"Diabetes"},{"key":"8941_CR151","doi-asserted-by":"publisher","first-page":"288","DOI":"10.2203\/dose-response.13-035.Ristow","volume":"12","author":"M Ristow","year":"2014","unstructured":"Ristow M, Schmeisser K (2014) Mitohormesis: promoting health and lifespan by increased levels of reactive oxygen species (ROS). Dose-Response 12:288\u2013341. https:\/\/doi.org\/10.2203\/dose-response.13-035.Ristow","journal-title":"Dose-Response"},{"key":"8941_CR152","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.mce.2017.04.011","volume":"455","author":"SK Das","year":"2017","unstructured":"Das SK, Balasubramanian P, Weerasekara YK (2017) Nutrition modulation of human aging: the calorie restriction paradigm. Mol Cell Endocrinol 455:148\u2013157. https:\/\/doi.org\/10.1016\/j.mce.2017.04.011","journal-title":"Mol Cell Endocrinol"},{"key":"8941_CR153","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.tem.2014.07.002","volume":"25","author":"H Mirzaei","year":"2014","unstructured":"Mirzaei H, Suarez JA, Longo VD (2014) Protein and amino acid restriction, aging and disease: from yeast to humans. Trends Endocrinol Metab 25:558\u2013566","journal-title":"Trends Endocrinol Metab"},{"key":"8941_CR154","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1002\/ART.33388","volume":"64","author":"RF Loeser","year":"2012","unstructured":"Loeser RF, Olex AL, McNulty MA et al (2012) Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice. Arthritis Rheum 64:705\u2013717. https:\/\/doi.org\/10.1002\/ART.33388","journal-title":"Arthritis Rheum"},{"key":"8941_CR155","doi-asserted-by":"publisher","unstructured":"Long D, Blake S, Song XY et al (2008)\u00a0Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13. Arthritis Res Ther 10.\u00a0https:\/\/doi.org\/10.1186\/AR2376","DOI":"10.1186\/AR2376"},{"key":"8941_CR156","doi-asserted-by":"publisher","unstructured":"Rezu\u0219 E,\u00a0Cardoneanu A, Burlui A et al (2019)\u00a0The link between inflammaging and degenerative joint diseases. Int J Mol Sci 20.\u00a0https:\/\/doi.org\/10.3390\/IJMS20030614","DOI":"10.3390\/IJMS20030614"},{"key":"8941_CR157","first-page":"48","volume":"37","author":"M Millerand","year":"2019","unstructured":"Millerand M, Berenbaum F, Jacques C (2019) Danger signals and inflammaging in osteoarthritis. Clin Exp Rheumatol 37:48\u201356","journal-title":"Clin Exp Rheumatol"},{"key":"8941_CR158","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/j.joca.2010.03.016","volume":"18","author":"RJ Goekoop","year":"2010","unstructured":"Goekoop RJ, Kloppenburg M, Kroon HM et al (2010) Low innate production of interleukin-1\u03b2 and interleukin-6 is associated with the absence of osteoarthritis in old age. Osteoarthr Cartil 18:942\u2013947. https:\/\/doi.org\/10.1016\/j.joca.2010.03.016","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR159","doi-asserted-by":"publisher","unstructured":"Ni Z, Kuang L, Chen H et al (2019)\u00a0The exosome-like vesicles from osteoarthritic chondrocyte enhanced mature IL-1\u03b2 production of macrophages and aggravated synovitis in osteoarthritis. Cell Death Dis 10.\u00a0https:\/\/doi.org\/10.1038\/s41419-019-1739-2","DOI":"10.1038\/s41419-019-1739-2"},{"key":"8941_CR160","doi-asserted-by":"publisher","unstructured":"Kato T, Miyaki S, Ishitobi H et al (2014)\u00a0Exosomes from IL-1\u03b2 stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes. Arthritis Res Ther 16.\u00a0https:\/\/doi.org\/10.1186\/ar4679","DOI":"10.1186\/ar4679"},{"key":"8941_CR161","doi-asserted-by":"publisher","unstructured":"Chien SY, Tsai CH, Liu SC et al (2020)\u00a0Noggin inhibits IL-1\u03b2 and BMP-2 expression, and attenuates cartilage degeneration and subchondral bone destruction in experimental osteoarthritis. Cells 9.\u00a0https:\/\/doi.org\/10.3390\/cells9040927","DOI":"10.3390\/cells9040927"},{"key":"8941_CR162","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1136\/annrheumdis-2015-207487","volume":"75","author":"S Nasi","year":"2016","unstructured":"Nasi S, So A, Combes C et al (2016) Interleukin-6 and chondrocyte mineralisation act in tandem to promote experimental osteoarthritis. Ann Rheum Dis 75:1372\u20131379. https:\/\/doi.org\/10.1136\/annrheumdis-2015-207487","journal-title":"Ann Rheum Dis"},{"key":"8941_CR163","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/nrrheum.2016.65","volume":"12","author":"RF Loeser","year":"2016","unstructured":"Loeser RF, Collins JA, Diekman BO (2016) Ageing and the pathogenesis of osteoarthritis. Nat Rev Rheumatol 12:412\u2013420","journal-title":"Nat Rev Rheumatol"},{"key":"8941_CR164","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1080\/03008207.2016.1240790","volume":"58","author":"H Jeon","year":"2017","unstructured":"Jeon H, Il IG (2017) Autophagy in osteoarthritis. Connect Tissue Res 58:497\u2013508. https:\/\/doi.org\/10.1080\/03008207.2016.1240790","journal-title":"Connect Tissue Res"},{"key":"8941_CR165","doi-asserted-by":"publisher","unstructured":"Gao T, Guo W, Chen M et al (2016)\u00a0Extracellular vesicles and autophagy in osteoarthritis. Biomed Res Int 2016. https:\/\/doi.org\/10.1155\/2016\/2428915","DOI":"10.1155\/2016\/2428915"},{"key":"8941_CR166","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1016\/j.joca.2015.06.018","volume":"23","author":"F Ponchel","year":"2015","unstructured":"Ponchel F, Burska AN, Hensor EMA et al (2015) Changes in peripheral blood immune cell composition in osteoarthritis. Osteoarthr Cartil 23:1870\u20131878. https:\/\/doi.org\/10.1016\/j.joca.2015.06.018","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR167","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s10067-019-04768-y","volume":"39","author":"W Zhu","year":"2020","unstructured":"Zhu W, Zhang X, Jiang Y et al (2020) Alterations in peripheral T cell and B cell subsets in patients with osteoarthritis. Clin Rheumatol 39:523\u2013532. https:\/\/doi.org\/10.1007\/s10067-019-04768-y","journal-title":"Clin Rheumatol"},{"key":"8941_CR168","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.3892\/mmr.2017.6132","volume":"15","author":"Y Shan","year":"2017","unstructured":"Shan Y, Qi C, Liu Y et al (2017) Increased frequency of peripheral blood follicular helper T cells and elevated serum IL-21 levels in patients with knee osteoarthritis. Mol Med Rep 15:1095\u20131102. https:\/\/doi.org\/10.3892\/mmr.2017.6132","journal-title":"Mol Med Rep"},{"key":"8941_CR169","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1016\/J.JOCA.2012.08.027","volume":"20","author":"BJE de Lange-Brokaar","year":"2012","unstructured":"de Lange-Brokaar BJE, Ioan-Facsinay A, van Osch GJVM et al (2012) Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review. Osteoarthr Cartil 20:1484\u20131499. https:\/\/doi.org\/10.1016\/J.JOCA.2012.08.027","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR170","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1007\/S10067-008-0878-0","volume":"27","author":"F Pessler","year":"2008","unstructured":"Pessler F, Chen LX, Dai L et al (2008) A histomorphometric analysis of synovial biopsies from individuals with Gulf War Veterans\u2019 illness and joint pain compared to normal and osteoarthritis synovium. Clin Rheumatol 27:1127\u20131134. https:\/\/doi.org\/10.1007\/S10067-008-0878-0","journal-title":"Clin Rheumatol"},{"key":"8941_CR171","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1096\/fj.201500088R","volume":"30","author":"TP Mikolajczyk","year":"2016","unstructured":"Mikolajczyk TP, Nosalski R, Szczepaniak P et al (2016) Role of chemokine RANTES in the regulation of perivascular inflammation, T-cell accumulation, and vascular dysfunction in hypertension. FASEB J 30:1987\u20131999. https:\/\/doi.org\/10.1096\/fj.201500088R","journal-title":"FASEB J"},{"key":"8941_CR172","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/S11914-017-0411-Y","volume":"15","author":"EBP Lopes","year":"2017","unstructured":"Lopes EBP, Filiberti A, Husain SA, Humphrey MB (2017) Immune contributions to osteoarthritis. Curr Osteoporos Rep 15:593\u2013600. https:\/\/doi.org\/10.1007\/S11914-017-0411-Y","journal-title":"Curr Osteoporos Rep"},{"key":"8941_CR173","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3109\/03009742.2015.1060259","volume":"45","author":"AS Siebuhr","year":"2016","unstructured":"Siebuhr AS, Bay-Jensen AC, Jordan JM et al (2016) Inflammation (or synovitis)-driven osteoarthritis: an opportunity for personalizing prognosis and treatment? Scand J Rheumatol 45:87\u201398","journal-title":"Scand J Rheumatol"},{"key":"8941_CR174","doi-asserted-by":"publisher","unstructured":"Fried LP, Tangen CM, Walston J et al (2001)\u00a0Frailty in older adults: evidence for a phenotype. J Gerontol - Ser A Biol Sci Med Sci 56.\u00a0https:\/\/doi.org\/10.1093\/gerona\/56.3.m146","DOI":"10.1093\/gerona\/56.3.m146"},{"key":"8941_CR175","doi-asserted-by":"publisher","first-page":"23","DOI":"10.2147\/RMHP.S168750","volume":"12","author":"G Kojima","year":"2019","unstructured":"Kojima G, Liljas AEM, Iliffe S (2019) Frailty syndrome: implications and challenges for health care policy. Risk Manag Healthc Policy 12:23\u201330","journal-title":"Risk Manag Healthc Policy"},{"key":"8941_CR176","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","volume":"15","author":"L Ferrucci","year":"2018","unstructured":"Ferrucci L, Fabbri E (2018) Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol 15:505\u2013522","journal-title":"Nat Rev Cardiol"},{"key":"8941_CR177","doi-asserted-by":"publisher","unstructured":"Motta F, Sica A, Selmi C (2020)\u00a0Frailty in rheumatic diseases. Front Immunol 11.\u00a0https:\/\/doi.org\/10.3389\/FIMMU.2020.576134","DOI":"10.3389\/FIMMU.2020.576134"},{"key":"8941_CR178","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1093\/RHEUMATOLOGY\/KET348","volume":"53","author":"F Cacciatore","year":"2014","unstructured":"Cacciatore F, Della-morte D, Basile C et al (2014) Long-term mortality in frail elderly subjects with osteoarthritis. Rheumatology (Oxford) 53:293\u2013299. https:\/\/doi.org\/10.1093\/RHEUMATOLOGY\/KET348","journal-title":"Rheumatology (Oxford)"},{"key":"8941_CR179","doi-asserted-by":"publisher","unstructured":"Chen P, Huang L, Ma Y et al (2019)\u00a0Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses. J Orthop Surg Res 14.\u00a0https:\/\/doi.org\/10.1186\/s13018-019-1363-y","DOI":"10.1186\/s13018-019-1363-y"},{"key":"8941_CR180","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/J.CSM.2018.08.001","volume":"38","author":"ADK Le","year":"2019","unstructured":"Le ADK, Enweze L, DeBaun MR, Dragoo JL (2019) Platelet-rich plasma. Clin Sports Med 38:17\u201344. https:\/\/doi.org\/10.1016\/J.CSM.2018.08.001","journal-title":"Clin Sports Med"},{"key":"8941_CR181","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1002\/JCB.22344","volume":"108","author":"A Spreafico","year":"2009","unstructured":"Spreafico A, Chellini F, Frediani B et al (2009) Biochemical investigation of the effects of human platelet releasates on human articular chondrocytes. J Cell Biochem 108:1153\u20131165. https:\/\/doi.org\/10.1002\/JCB.22344","journal-title":"J Cell Biochem"},{"key":"8941_CR182","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1016\/J.ARTHRO.2013.03.004","volume":"29","author":"NA Smyth","year":"2013","unstructured":"Smyth NA, Murawski CD, Fortier LA et al (2013) Platelet-rich plasma in the pathologic processes of cartilage: review of basic science evidence. Arthroscopy 29:1399\u20131409. https:\/\/doi.org\/10.1016\/J.ARTHRO.2013.03.004","journal-title":"Arthroscopy"},{"key":"8941_CR183","doi-asserted-by":"publisher","unstructured":"Battaglia M, Guaraldi F, Vannini F et al (2013)\u00a0Efficacy of ultrasound-guided intra-articular injections of platelet-rich plasma versus hyaluronic acid for hip osteoarthritis. Orthopedics 36.\u00a0https:\/\/doi.org\/10.3928\/01477447-20131120-13","DOI":"10.3928\/01477447-20131120-13"},{"key":"8941_CR184","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1177\/0363546515620383","volume":"44","author":"D Dallari","year":"2016","unstructured":"Dallari D, Stagni C, Rani N et al (2016) Ultrasound-guided injection of platelet-rich plasma and hyaluronic acid, separately and in combination, for hip osteoarthritis: a randomized controlled study. Am J Sports Med 44:664\u2013671. https:\/\/doi.org\/10.1177\/0363546515620383","journal-title":"Am J Sports Med"},{"key":"8941_CR185","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1055\/S-0037-1605584","volume":"5","author":"C Doria","year":"2017","unstructured":"Doria C, Mosele GR, Caggiari G et al (2017) Treatment of early hip osteoarthritis: ultrasound-guided platelet rich plasma versus hyaluronic acid injections in a randomized clinical trial. Joints 5:152\u2013155. https:\/\/doi.org\/10.1055\/S-0037-1605584","journal-title":"Joints"},{"key":"8941_CR186","doi-asserted-by":"publisher","first-page":"463","DOI":"10.11152\/MU-874","volume":"18","author":"L Di Sante","year":"2016","unstructured":"Di Sante L, Villani C, Santilli V et al (2016) Intra-articular hyaluronic acid vs platelet-rich plasma in the treatment of hip osteoarthritis. Med Ultrason 18:463\u2013468. https:\/\/doi.org\/10.11152\/MU-874","journal-title":"Med Ultrason"},{"key":"8941_CR187","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/NRD.2016.231","volume":"16","author":"JA Hamilton","year":"2016","unstructured":"Hamilton JA, Cook AD, Tak PP (2016) Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases. Nat Rev Drug Discov 16:53\u201370. https:\/\/doi.org\/10.1038\/NRD.2016.231","journal-title":"Nat Rev Drug Discov"},{"key":"8941_CR188","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.joca.2020.01.012","volume":"28","author":"KMC Lee","year":"2020","unstructured":"Lee KMC, Prasad V, Achuthan A et al (2020) Targeting GM-CSF for collagenase-induced osteoarthritis pain and disease in mice. Osteoarthr Cartil 28:486\u2013491. https:\/\/doi.org\/10.1016\/j.joca.2020.01.012","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR189","doi-asserted-by":"publisher","unstructured":"Cook AD, Pobjoy J, Steidl S et al (2012)\u00a0Granulocyte-macrophage colony-stimulating factor is a key mediator in experimental osteoarthritis pain and disease development. Arthritis Res Ther 14.\u00a0https:\/\/doi.org\/10.1186\/AR4037","DOI":"10.1186\/AR4037"},{"key":"8941_CR190","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.joca.2018.05.005","volume":"26","author":"C Steen-Louws","year":"2018","unstructured":"Steen-Louws C, Popov-Celeketic J, Mastbergen SC et al (2018) IL4-10 fusion protein has chondroprotective, anti-inflammatory and potentially analgesic effects in the treatment of osteoarthritis. Osteoarthr Cartil 26:1127\u20131135. https:\/\/doi.org\/10.1016\/j.joca.2018.05.005","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR191","doi-asserted-by":"publisher","first-page":"1155S","DOI":"10.1177\/19476035211026736","volume":"13","author":"EM van Helvoort","year":"2021","unstructured":"van Helvoort EM, de Visser HM, Lafeber FPJG et al (2021) IL4-10 fusion protein shows DMOAD activity in a rat osteoarthritis model. Cartilage 13:1155S-1164S. https:\/\/doi.org\/10.1177\/19476035211026736","journal-title":"Cartilage"},{"key":"8941_CR192","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1159\/000456090","volume":"41","author":"HS Hwang","year":"2017","unstructured":"Hwang HS, Park IY, Choi SY, Kim HA (2017) PEP-1-GRX-1 modulates matrix metalloproteinase-13 and nitric oxide expression of human articular chondrocytes. Cell Physiol Biochem 41:252\u2013264. https:\/\/doi.org\/10.1159\/000456090","journal-title":"Cell Physiol Biochem"},{"key":"8941_CR193","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1007\/s10495-016-1280-z","volume":"21","author":"ZH Bin","year":"2016","unstructured":"Bin ZH, Zhang Y, Chen C et al (2016) Pioglitazone inhibits advanced glycation end product-induced matrix metalloproteinases and apoptosis by suppressing the activation of MAPK and NF-\u03baB. Apoptosis 21:1082\u20131093. https:\/\/doi.org\/10.1007\/s10495-016-1280-z","journal-title":"Apoptosis"},{"key":"8941_CR194","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/biof.202","volume":"38","author":"GM Campo","year":"2012","unstructured":"Campo GM, Avenoso A, D\u2019Ascola A et al (2012) Hyaluronan differently modulates TLR-4 and the inflammatory response in mouse chondrocytes. BioFactors 38:69\u201376. https:\/\/doi.org\/10.1002\/biof.202","journal-title":"BioFactors"},{"key":"8941_CR195","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/J.JOCA.2015.08.001","volume":"24","author":"Y Li","year":"2016","unstructured":"Li Y, Zhang Y, Chen C et al (2016) Establishment of a rabbit model to study the influence of advanced glycation end products accumulation on osteoarthritis and the protective effect of pioglitazone. Osteoarthr Cartil 24:307\u2013314. https:\/\/doi.org\/10.1016\/J.JOCA.2015.08.001","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR196","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1002\/ART.22726","volume":"56","author":"C Boileau","year":"2007","unstructured":"Boileau C, Martel-Pelletier J, Fahmi H et al (2007) The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: in vivo protective effects mediated through the inhibition of key signaling and catabolic pathways. Arthritis Rheum 56:2288\u20132298. https:\/\/doi.org\/10.1002\/ART.22726","journal-title":"Arthritis Rheum"},{"key":"8941_CR197","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1002\/ART.20792","volume":"52","author":"T Kobayashi","year":"2005","unstructured":"Kobayashi T, Notoya K, Naito T et al (2005) Pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, reduces the progression of experimental osteoarthritis in guinea pigs. Arthritis Rheum 52:479\u2013487. https:\/\/doi.org\/10.1002\/ART.20792","journal-title":"Arthritis Rheum"},{"key":"8941_CR198","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/j.clinbiochem.2010.07.007","volume":"43","author":"M Chayanupatkul","year":"2010","unstructured":"Chayanupatkul M, Honsawek S (2010) Soluble receptor for advanced glycation end products (sRAGE) in plasma and synovial fluid is inversely associated with disease severity of knee osteoarthritis. Clin Biochem 43:1133\u20131137. https:\/\/doi.org\/10.1016\/j.clinbiochem.2010.07.007","journal-title":"Clin Biochem"},{"key":"8941_CR199","doi-asserted-by":"publisher","first-page":"555","DOI":"10.2741\/4735","volume":"24","author":"Y Peng","year":"2019","unstructured":"Peng Y, Park HS, Tang LA et al (2019) Generation of sRAGE high transgenic mice to study inflammaging. Front Biosci - Landmark 24:555\u2013563. https:\/\/doi.org\/10.2741\/4735","journal-title":"Front Biosci - Landmark"},{"key":"8941_CR200","doi-asserted-by":"publisher","unstructured":"Luo Y, Li J, Wang B et al (2021)\u00a0Protective effect of glycyrrhizin on osteoarthritis cartilage degeneration and inflammation response in a rat model. J Bioenerg Biomembr\u00a053:285\u2013293.\u00a0https:\/\/doi.org\/10.1007\/S10863-021-09889-1","DOI":"10.1007\/S10863-021-09889-1"},{"key":"8941_CR201","doi-asserted-by":"publisher","unstructured":"Olcum M, Tufekci KU, Durur DY et al (2021) Ethyl\u00a0Ethyl pyruvate attenuates microglial NLRP3 inflammasome activation via inhibition of HMGB1\/NF-\u03baB\/miR-223 signaling. Antioxidants (Basel, Switzerland) 10.\u00a0https:\/\/doi.org\/10.3390\/ANTIOX10050745","DOI":"10.3390\/ANTIOX10050745"},{"key":"8941_CR202","doi-asserted-by":"publisher","unstructured":"Luo Y, Li J, Wang B et al (2021)\u00a0Protective effect of glycyrrhizin on osteoarthritis cartilage degeneration and inflammation response in a rat model. J Bioenerg Biomembr 53.\u00a0https:\/\/doi.org\/10.1007\/s10863-021-09889-1","DOI":"10.1007\/s10863-021-09889-1"},{"key":"8941_CR203","doi-asserted-by":"publisher","unstructured":"Li S, Liang F, Kwan K et al (2018)\u00a0Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity. Mol Med 24.\u00a0https:\/\/doi.org\/10.1186\/s10020-018-0006-9","DOI":"10.1186\/s10020-018-0006-9"},{"key":"8941_CR204","doi-asserted-by":"publisher","first-page":"3406","DOI":"10.1002\/jcp.30125","volume":"236","author":"J Xue","year":"2021","unstructured":"Xue J, Suarez JS, Minaai M et al (2021) HMGB1 as a therapeutic target in disease. J Cell Physiol 236:3406\u20133419","journal-title":"J Cell Physiol"},{"key":"8941_CR205","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.joca.2020.01.003","volume":"28","author":"C Aulin","year":"2020","unstructured":"Aulin C, Lassacher T, Palmblad K, Erlandsson Harris H (2020) Early stage blockade of the alarmin HMGB1 reduces cartilage destruction in experimental OA. Osteoarthr Cartil 28:698\u2013707. https:\/\/doi.org\/10.1016\/j.joca.2020.01.003","journal-title":"Osteoarthr Cartil"},{"key":"8941_CR206","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1136\/annrheumdis-2014-206517","volume":"74","author":"RF Schelbergen","year":"2015","unstructured":"Schelbergen RF, Geven EJ, Van Den Bosch MHJ et al (2015) Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis. Ann Rheum Dis 74:2254\u20132258. https:\/\/doi.org\/10.1136\/annrheumdis-2014-206517","journal-title":"Ann Rheum Dis"},{"key":"8941_CR207","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.3899\/jrheum.160270","volume":"43","author":"MH Van Den Bosch","year":"2016","unstructured":"Van Den Bosch MH, Blom AB, Schelbergen RF et al (2016) Alarmin S100A9 induces proinflammatory and catabolic effects predominantly in the M1 macrophages of human osteoarthritic synovium. J Rheumatol 43:1874\u20131884. https:\/\/doi.org\/10.3899\/jrheum.160270","journal-title":"J Rheumatol"},{"key":"8941_CR208","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/cei.13237","volume":"195","author":"MHJ van den Bosch","year":"2019","unstructured":"van den Bosch MHJ (2019) Inflammation in osteoarthritis: is it time to dampen the alarm(in) in this debilitating disease? Clin Exp Immunol 195:153\u2013166","journal-title":"Clin Exp Immunol"},{"key":"8941_CR209","doi-asserted-by":"publisher","unstructured":"Cremers NAJ, van den Bosch MHJ, van Dalen S et al (2017)\u00a0S100A8\/A9 increases the mobilization of pro-inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis. Arthritis Res Ther 19.\u00a0https:\/\/doi.org\/10.1186\/s13075-017-1426-6","DOI":"10.1186\/s13075-017-1426-6"},{"key":"8941_CR210","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/nm.4324","volume":"23","author":"OH Jeon","year":"2017","unstructured":"Jeon OH, Kim C, Laberge RM et al (2017) Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment. Nat Med 23:775\u2013781. https:\/\/doi.org\/10.1038\/nm.4324","journal-title":"Nat Med"},{"key":"8941_CR211","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1097\/BOR.0000000000000845","volume":"34","author":"AC Bay-Jensen","year":"2022","unstructured":"Bay-Jensen AC, Mobasheri A, Thudium CS et al (2022) Blood and urine biomarkers in osteoarthritis - an update on cartilage associated type II collagen and aggrecan markers. Curr Opin Rheumatol 34:54\u201360. https:\/\/doi.org\/10.1097\/BOR.0000000000000845","journal-title":"Curr Opin Rheumatol"},{"key":"8941_CR212","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1136\/ANNRHEUMDIS-2016-209252","volume":"76","author":"VB Kraus","year":"2017","unstructured":"Kraus VB, Collins JE, Hargrove D et al (2017) Predictive validity of biochemical biomarkers in knee osteoarthritis: data from the FNIH OA Biomarkers Consortium. Ann Rheum Dis 76:186\u2013195. https:\/\/doi.org\/10.1136\/ANNRHEUMDIS-2016-209252","journal-title":"Ann Rheum Dis"},{"key":"8941_CR213","doi-asserted-by":"publisher","unstructured":"Luo Y, He Y, Reker D et al (2018)\u00a0A novel high sensitivity type II collagen blood-based biomarker, PRO-C2, for assessment of cartilage formation. Int J Mol Sci 19.\u00a0https:\/\/doi.org\/10.3390\/IJMS19113485","DOI":"10.3390\/IJMS19113485"},{"key":"8941_CR214","doi-asserted-by":"publisher","unstructured":"Siebuhr AS, Bay-Jensen AC, Leeming DJ et al (2013)\u00a0Serological identification of fast progressors of structural damage with rheumatoid arthritis. Arthritis Res Ther 15.\u00a0https:\/\/doi.org\/10.1186\/AR4266","DOI":"10.1186\/AR4266"},{"key":"8941_CR215","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/J.1749-6632.2009.05240.X","volume":"1192","author":"MB Goldring","year":"2010","unstructured":"Goldring MB, Goldring SR (2010) Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis. Ann N Y Acad Sci 1192:230\u2013237. https:\/\/doi.org\/10.1111\/J.1749-6632.2009.05240.X","journal-title":"Ann N Y Acad Sci"},{"key":"8941_CR216","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.1002\/ART.38739","volume":"66","author":"JL Huebner","year":"2014","unstructured":"Huebner JL, Bay-Jensen AC, Huffman KM et al (2014) Alpha C-telopeptide of type I collagen is associated with subchondral bone turnover and predicts progression of joint space narrowing and osteophytes in osteoarthritis. Arthritis Rheumatol (Hoboken, NJ) 66:2440\u20132449. https:\/\/doi.org\/10.1002\/ART.38739","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"},{"key":"8941_CR217","doi-asserted-by":"crossref","unstructured":"Engbersen M, Huang ZKV (2016) Bone biomarkers related to osteoarthritis. In: Preedy V (ed) Biomarkers in disease: methods, discoveries and applications. Dordrecht","DOI":"10.1007\/978-94-007-7745-3_35-1"},{"key":"8941_CR218","doi-asserted-by":"publisher","unstructured":"Haraden CA, Huebner JL, Hsueh MF et al (2019)\u00a0Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation. Arthritis Res Ther 21.\u00a0https:\/\/doi.org\/10.1186\/S13075-019-1923-X","DOI":"10.1186\/S13075-019-1923-X"},{"key":"8941_CR219","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1002\/ART.41486","volume":"73","author":"MF Hsueh","year":"2021","unstructured":"Hsueh MF, Zhang X, Wellman SS et al (2021) Synergistic roles of macrophages and neutrophils in osteoarthritis progression. Arthritis Rheumatol (Hoboken, NJ) 73:89\u201399. https:\/\/doi.org\/10.1002\/ART.41486","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"},{"key":"8941_CR220","doi-asserted-by":"publisher","unstructured":"Sunahori K, Yamamura M, Yamana J et al (2006)\u00a0The S100A8\/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis. Arthritis Res Ther 8.\u00a0https:\/\/doi.org\/10.1186\/AR1939","DOI":"10.1186\/AR1939"},{"key":"8941_CR221","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1002\/ART.34315","volume":"64","author":"PLEM Van Lent","year":"2012","unstructured":"Van Lent PLEM, Blom AB, Schelbergen RFP et al (2012) Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis. Arthritis Rheum 64:1466\u20131476. https:\/\/doi.org\/10.1002\/ART.34315","journal-title":"Arthritis Rheum"},{"key":"8941_CR222","doi-asserted-by":"publisher","unstructured":"Swindell WR, Johnston A, Xing X et al (2013)\u00a0Robust shifts in S100a9 expression with aging: a novel mechanism for chronic inflammation. Sci Rep 3.\u00a0https:\/\/doi.org\/10.1038\/SREP01215","DOI":"10.1038\/SREP01215"},{"key":"8941_CR223","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1136\/ANNRHEUMDIS-2012-201329","volume":"71","author":"J Gerss","year":"2012","unstructured":"Gerss J, Roth J, Holzinger D et al (2012) Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative study. Ann Rheum Dis 71:1991\u20131997. https:\/\/doi.org\/10.1136\/ANNRHEUMDIS-2012-201329","journal-title":"Ann Rheum Dis"},{"key":"8941_CR224","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1136\/ANNRHEUMDIS-2013-203923","volume":"74","author":"IY Choi","year":"2015","unstructured":"Choi IY, Gerlag DM, Herenius MJ et al (2015) MRP8\/14 serum levels as a strong predictor of response to biological treatments in patients with rheumatoid arthritis. Ann Rheum Dis 74:499\u2013505. https:\/\/doi.org\/10.1136\/ANNRHEUMDIS-2013-203923","journal-title":"Ann Rheum Dis"},{"key":"8941_CR225","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1002\/ART.38369","volume":"66","author":"D Holzinger","year":"2014","unstructured":"Holzinger D, Nippe N, Vogl T et al (2014) Myeloid-related proteins 8 and 14 contribute to monosodium urate monohydrate crystal-induced inflammation in gout. Arthritis Rheumatol (Hoboken, NJ) 66:1327\u20131339. https:\/\/doi.org\/10.1002\/ART.38369","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"}],"container-title":["Clinical Reviews in Allergy & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-022-08941-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12016-022-08941-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-022-08941-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T05:30:20Z","timestamp":1678858220000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12016-022-08941-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,18]]},"references-count":225,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["8941"],"URL":"https:\/\/doi.org\/10.1007\/s12016-022-08941-1","relation":{},"ISSN":["1559-0267"],"issn-type":[{"value":"1559-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,18]]},"assertion":[{"value":"18 April 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}