{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T21:58:16Z","timestamp":1780955896566,"version":"3.54.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clinic Rev Allerg Immunol"],"DOI":"10.1007\/s12016-024-08990-8","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T06:02:11Z","timestamp":1711346531000},"page":"125-137","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["From Skin to Solution: Exploring Epicutaneous Immunotherapy for Peanut Allergy\u2014A Systematic Review and Meta-Analysis"],"prefix":"10.1007","volume":"66","author":[{"given":"Umm E Salma Shabbar","family":"Banatwala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Moiz","family":"Nasir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reema","family":"Javed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areeba","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Ali","family":"Farhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ajam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,25]]},"reference":[{"key":"8990_CR1","unstructured":"Lopez CM, Yarrarapu SNS, Mendez MD (2023) Food allergies. In: StatPearls [Internet]. Treasure Island (FL):\u00a0StatPearls Publishing [cited 2023 Jul 26]. Available from:\u00a0http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482187\/"},{"key":"8990_CR2","doi-asserted-by":"crossref","unstructured":"Loh W, Tang MLK (2018) The epidemiology of food allergy in the global context. Int J Environ Res Public Health [Internet]. [cited 2023 Jul 26];15(9):2043. Available from:\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6163515\/\u00a0","DOI":"10.3390\/ijerph15092043"},{"issue":"1","key":"8990_CR3","doi-asserted-by":"publisher","first-page":"e185630","DOI":"10.1001\/jamanetworkopen.2018.5630","volume":"2","author":"RS Gupta","year":"2019","unstructured":"Gupta RS, Warren CM, Smith BM, Jiang J, Blumenstock JA, Davis MM et al (2019) Prevalence and severity of food allergies among us adults. JAMA Netw Open 2(1):e185630","journal-title":"JAMA Netw Open"},{"key":"8990_CR4","unstructured":"Patel R, Koterba AP (2023) Peanut allergy. In: StatPearls [Internet]. Treasure Island (FL):\u00a0StatPearls Publishing [cited 2023 Jul 26]. Available from: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK538526\/"},{"issue":"1","key":"8990_CR5","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1067\/mai.2001.112031","volume":"107","author":"SA Bock","year":"2001","unstructured":"Bock SA, Mu\u00f1oz-Furlong A, Sampson HA (2001) Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol 107(1):191\u2013193","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"8990_CR6","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/pai.13215","volume":"31","author":"A Krogulska","year":"2020","unstructured":"Krogulska A, Wood RA (2020) Peanut allergy diagnosis: moving from basic to more elegant testing. Pediatr Allergy Immunol 31(4):346\u2013357","journal-title":"Pediatr Allergy Immunol"},{"key":"8990_CR7","doi-asserted-by":"crossref","unstructured":"Palladino C, Breiteneder H (2018) Peanut allergens. Mol Immunol [Internet].\u00a0[cited 2023 Jul 26]; 100:58\u201370. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0161589018301226","DOI":"10.1016\/j.molimm.2018.04.005"},{"key":"8990_CR8","unstructured":"Who\/iuis allergen nomenclature home page [Internet]. [cited 2023 Jul 26]. Available from: http:\/\/www.allergen.org\/index.php"},{"key":"8990_CR9","unstructured":"Dougherty JM, Alsayouri K, Sadowski A (2023) Allergy. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing [cited 2023 Jul 26]. Available from: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK545237\/"},{"issue":"3","key":"8990_CR10","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s12016-018-8703-2","volume":"57","author":"J Shroba","year":"2019","unstructured":"Shroba J, Rath N, Barnes C (2019) Possible role of environmental factors in the development of food allergies. Clin Rev Allergy Immunol 57(3):303\u2013311","journal-title":"Clin Rev Allergy Immunol"},{"issue":"9","key":"8990_CR11","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1056\/NEJMoa1414850","volume":"372","author":"G Du Toit","year":"2015","unstructured":"Du Toit G, Roberts G, Sayre PH, Bahnson HT, Radulovic S, Santos AF et al (2015) Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med 372(9):803\u2013813","journal-title":"N Engl J Med"},{"key":"8990_CR12","doi-asserted-by":"crossref","unstructured":"Eimear O, Hilary T, Andrew C, Andrew L, Sindher S, Sharon CR (2022) Current insights: a systemic review of therapeutic options for peanut allergy. Curr Opin Allergy Clin Immunol [Internet].\u00a0[cited 2023 Jul 26];22(3):188\u2013193. Available from: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9178908\/","DOI":"10.1097\/ACI.0000000000000824"},{"key":"8990_CR13","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s13223-020-0413-7","volume":"16","author":"P B\u00e9gin","year":"2020","unstructured":"B\u00e9gin P, Chan ES, Kim H, Wagner M, Cellier MS, Favron-Godbout C et al (2020) CSACI guidelines for the ethical, evidence-based and patient-oriented clinical practice of oral immunotherapy in IgE-mediated food allergy. Allergy Asthma Clin Immunol 16:20","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"10187","key":"8990_CR14","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.1016\/S0140-6736(19)30420-9","volume":"393","author":"DK Chu","year":"2019","unstructured":"Chu DK, Wood RA, French S, Fiocchi A, Jordana M, Waserman S et al (2019) Oral immunotherapy for peanut allergy (Pace): a systematic review and meta-analysis of efficacy and safety. Lancet 393(10187):2222\u20132232","journal-title":"Lancet"},{"key":"8990_CR15","doi-asserted-by":"crossref","unstructured":"Fiocchi A, Artesani MC, Fierro V, Riccardi C, Dahdah L, Mennini M (2020) Oral immunotherapy for peanut allergy: the con argument.\u00a0World Allergy Organ J\u00a0[Internet].\u00a0[cited 2023 Jul 26];13(8):100445. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1939455120303483","DOI":"10.1016\/j.waojou.2020.100445"},{"issue":"4","key":"8990_CR16","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1111\/pai.12869","volume":"29","author":"J Wang","year":"2018","unstructured":"Wang J, Sampson HA (2018) Safety and efficacy of epicutaneous immunotherapy for food allergy. Pediatr Allergy Immunol 29(4):341\u2013349","journal-title":"Pediatr Allergy Immunol"},{"issue":"3","key":"8990_CR17","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1159\/000504366","volume":"181","author":"L Xiong","year":"2020","unstructured":"Xiong L, Lin J, Luo Y, Chen W, Dai J (2020) The efficacy and safety of epicutaneous immunotherapy for allergic diseases: a systematic review and meta-analysis. Int Arch Allergy Immunol 181(3):170\u2013182","journal-title":"Int Arch Allergy Immunol"},{"issue":"2","key":"8990_CR18","doi-asserted-by":"publisher","first-page":"171","DOI":"10.2500\/aap.2014.35.3730","volume":"35","author":"J Sun","year":"2014","unstructured":"Sun J, Hui X, Ying W, Liu D, Wang X (2014) Efficacy of allergen-specific immunotherapy for peanut allergy: a meta-analysis of randomized controlled trials. Allergy Asthma Proc 35(2):171\u2013177","journal-title":"Allergy Asthma Proc"},{"issue":"6","key":"8990_CR19","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1111\/all.15211","volume":"77","author":"D de Silva","year":"2022","unstructured":"de Silva D, Rodr\u00edguez Del R\u00edo P, de Jong NW, Khaleva E, Singh C, Nowak-Wegrzyn A et al (2022) Allergen immunotherapy and\/or biologicals for IgE-mediated food allergy: a systematic review and meta-analysis. Allergy 77(6):1852\u20131862","journal-title":"Allergy"},{"issue":"372","key":"8990_CR20","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","volume":"29","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 29(372):n71","journal-title":"BMJ"},{"key":"8990_CR21","doi-asserted-by":"crossref","unstructured":"Canonica GW, Baena-Cagnani CE, Bousquet J, Bousquet PJ, Lockey RF, Malling HJ et al (2007) Recommendations for standardization of clinical trials with allergen specific immunotherapy for respiratory allergy. A statement of a World Allergy Organization (Wao) taskforce: recommendations for immunotherapy clinical trials. Allergy [Internet].\u00a0[cited 2023 Jul 26];62(3):317\u2013324. Available from: https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1398-9995.2006.01312.x","DOI":"10.1111\/j.1398-9995.2006.01312.x"},{"key":"8990_CR22","unstructured":"Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors) (2022) Cochrane handbook for systematic reviews of interventions version 6.3 (updated February 2022). Cochrane.\u00a0www.training.cochrane.org\/handbook.\u00a0Accessed 25 Oct 2023"},{"key":"8990_CR23","doi-asserted-by":"crossref","unstructured":"Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J et al (2011) GRADE guidelines: 1. Introduction\u2014GRADE evidence profiles and summary of findings tables.\u00a0J Clin Epidemiol [Internet]. 64(4):383\u2013394. https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0895435610003306.\u00a0Accessed 30 Oct 2023","DOI":"10.1016\/j.jclinepi.2010.04.026"},{"key":"8990_CR24","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/1471-2288-14-135","volume":"14","author":"X Wan","year":"2014","unstructured":"Wan X, Wang W, Liu J, Tong T (2014) Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range. BMC Med Res Methodol 14:135","journal-title":"BMC Med Res Methodol"},{"issue":"19","key":"8990_CR25","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1056\/NEJMoa2212895","volume":"388","author":"M Greenhawt","year":"2023","unstructured":"Greenhawt M, Sindher SB, Wang J, O\u2019Sullivan M, Du Toit G, Kim EH, Albright D et al (2023) Phase 3 trial of epicutaneous immunotherapy in toddlers with peanut allergy. N Engl J Med 388(19):1755\u20131766. https:\/\/doi.org\/10.1056\/NEJMoa2212895","journal-title":"N Engl J Med"},{"issue":"7","key":"8990_CR26","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1016\/j.jaip.2021.11.017","volume":"10","author":"JA Pongracic","year":"2022","unstructured":"Pongracic JA, Gagnon R, Sussman G, Siri D, Oriel RC, Brown-Whitehorn TF, Green TD et al (2022) Safety of epicutaneous immunotherapy in peanut-allergic children: REALISE randomized clinical trial results. The Journal of Allergy and Clinical Immunology: In Practice 10(7):1864\u20131873.e10. https:\/\/doi.org\/10.1016\/j.jaip.2021.11.017","journal-title":"The Journal of Allergy and Clinical Immunology: In Practice"},{"issue":"10","key":"8990_CR27","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1001\/jama.2019.1113","volume":"321","author":"DM Fleischer","year":"2019","unstructured":"Fleischer DM, Greenhawt M, Sussman G, B\u00e9gin P, Nowak-Wegrzyn A, Petroni D, Beyer K et al (2019) Effect of epicutaneous immunotherapy vs placebo on reaction to peanut protein ingestion among children with peanut allergy. JAMA 321(10):946\u2013955. https:\/\/doi.org\/10.1001\/jama.2019.1113","journal-title":"JAMA"},{"issue":"4","key":"8990_CR28","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1016\/j.jaci.2016.08.017","volume":"139","author":"SM Jones","year":"2017","unstructured":"Jones SM, Sicherer SH, Burks AW, Leung DY, Lindblad RW, Dawson P, Henning AK et al (2017) Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults. J Allergy Clin Immunol 139(4):1242\u20131252.e9. https:\/\/doi.org\/10.1016\/j.jaci.2016.08.017","journal-title":"J Allergy Clin Immunol"},{"issue":"18","key":"8990_CR29","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1001\/jama.2017.16591","volume":"318","author":"HA Sampson","year":"2017","unstructured":"Sampson HA, Shreffler WG, Yang WH, Sussman GL, Brown-Whitehorn TF, Nadeau KC, Cheema AS et al (2017) Effect of varying doses of epicutaneous immunotherapy vs placebo on reaction to peanut protein exposure among patients with peanut sensitivity. JAMA 318(18):1798\u20131809. https:\/\/doi.org\/10.1001\/jama.2017.16591","journal-title":"JAMA"},{"issue":"4","key":"8990_CR30","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1016\/j.jaci.2016.01.008","volume":"137","author":"SM Jones","year":"2016","unstructured":"Jones SM, Agbotounou WK, Fleischer DM, Burks AW, Pesek RD, Harris MW, Martin L, Thebault C, Ruban C, Benhamou PH (2016) Safety of epicutaneous immunotherapy for the treatment of peanut allergy: a phase 1 study using the Viaskin patch. J Allergy Clin Immunol 137(4):1258\u20131261.e10. https:\/\/doi.org\/10.1016\/j.jaci.2016.01.008","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"8990_CR31","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.jaip.2020.08.017","volume":"9","author":"TF Brown-Whitehorn","year":"2021","unstructured":"Brown-Whitehorn TF, de Blay F, Spergel JM, Green TD, Peillon A, Sampson HA, Campbell DE (2021) Sustained unresponsiveness to peanut after long-term peanut epicutaneous immunotherapy. The Journal of Allergy and Clinical Immunology: In Practice 9(1):524\u2013526. https:\/\/doi.org\/10.1016\/j.jaip.2020.08.017","journal-title":"The Journal of Allergy and Clinical Immunology: In Practice"},{"issue":"4","key":"8990_CR32","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.jaci.2020.06.028","volume":"146","author":"DM Fleischer","year":"2020","unstructured":"Fleischer DM, Shreffler WG, Campbell DE, Green TD, Anvari S, Assa\u2019ad A, B\u00e9gin P, et al (2020) Long-term, open-label extension study of the efficacy and safety of epicutaneous immunotherapy for peanut allergy in children: PEOPLE 3-year results. J Allergy Clin Immunol 146(4):863\u2013874. https:\/\/doi.org\/10.1016\/j.jaci.2020.06.028","journal-title":"J Allergy Clin Immunol"},{"key":"8990_CR33","doi-asserted-by":"crossref","unstructured":"Bastin M, Carr WW, Davis CM, Fleischer DM, Lieberman JA, Mustafa SS et al (2023) Immune response evolution in peanut epicutaneous immunotherapy for peanut\u2010allergic children. Allergy [Internet]. 78(9):2467\u20132476.\u00a0https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.15709.\u00a0Accessed Nov 2023","DOI":"10.1111\/all.15709"},{"key":"8990_CR34","doi-asserted-by":"crossref","unstructured":"DunnGalvin A, Fleischer DM, Campbell DE, O\u2019B Hourihane J, Green TD, Sampson HA et al (2021) Improvements in quality of life in children following epicutaneous immunotherapy (Epit) for peanut allergy in the pepites and people studies.\u00a0JACI: In Practice\u00a0[Internet]. 9(1):216\u2013224.e1. https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221321982030831X.\u00a0Accessed Nov 2023","DOI":"10.1016\/j.jaip.2020.08.015"},{"issue":"3","key":"8990_CR35","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s40521-020-00271-x","volume":"7","author":"J Gupta","year":"2020","unstructured":"Gupta J, Margolis DJ (2020) Filaggrin gene mutations with special reference to atopic dermatitis. Current Treatment Options in Allergy 7(3):403\u2013413. https:\/\/doi.org\/10.1007\/s40521-020-00271-x","journal-title":"Current Treatment Options in Allergy"},{"key":"8990_CR36","unstructured":"(2020) Home \u2022 core outcome measures for food allergy [Internet].\u00a0European Cooperation in Science and Technology (COST). https:\/\/comfa.eu\/. Accessed Dec 2023"},{"issue":"5","key":"8990_CR37","doi-asserted-by":"publisher","first-page":"e193242","DOI":"10.1001\/jamanetworkopen.2019.3242","volume":"2","author":"M Shaker","year":"2019","unstructured":"Shaker M, Greenhawt M (2019) Estimation of health and economic benefits of commercial peanut immunotherapy products: a cost-effectiveness analysis. JAMA Network Open 2(5):e193242","journal-title":"JAMA Network Open"}],"container-title":["Clinical Reviews in Allergy &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-024-08990-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12016-024-08990-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-024-08990-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T09:09:14Z","timestamp":1719047354000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12016-024-08990-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,25]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["8990"],"URL":"https:\/\/doi.org\/10.1007\/s12016-024-08990-8","relation":{},"ISSN":["1559-0267"],"issn-type":[{"value":"1559-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,25]]},"assertion":[{"value":"16 March 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study does not require ethical approval since there was no direct interaction with humans or animals. Data from published trials has been used in this analysis.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Due to the nature of this study, informed consent from participants was not required as this study is a meta-analysis that includes trials that had these participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}