{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:36:02Z","timestamp":1793637362045,"version":"4.5.1"},"reference-count":134,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clinic Rev Allerg Immunol"],"DOI":"10.1007\/s12016-025-09073-y","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T16:32:59Z","timestamp":1750264379000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Current Understanding of Epithelial-Derived Alarmins in Chronic Rhinosinusitis with Nasal Polyps"],"prefix":"10.1007","volume":"68","author":[{"given":"Fuying","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaguang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1423-0942","authenticated-orcid":false,"given":"Xicai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"issue":"4","key":"9073_CR1","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.jaip.2016.04.012","volume":"4","author":"WW Stevens","year":"2016","unstructured":"Stevens WW, Schleimer RP, Kern RC (2016) Chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol Pract 4(4):565\u2013572. https:\/\/doi.org\/10.1016\/j.jaip.2016.04.012","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"3","key":"9073_CR2","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/j.jaip.2020.09.063","volume":"9","author":"TM Laidlaw","year":"2021","unstructured":"Laidlaw TM, Mullol J, Woessner KM, Amin N, Mannent LP (2021) Chronic rhinosinusitis with nasal polyps and asthma. J Allergy Clin Immunol Pract 9(3):1133\u20131141. https:\/\/doi.org\/10.1016\/j.jaip.2020.09.063","journal-title":"J Allergy Clin Immunol Pract"},{"key":"9073_CR3","doi-asserted-by":"publisher","unstructured":"Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S et al (2020) European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology 58(Suppl S29):1\u2013464. https:\/\/doi.org\/10.4193\/Rhin20.600","DOI":"10.4193\/Rhin20.600"},{"issue":"11","key":"9073_CR4","doi-asserted-by":"publisher","first-page":"2794","DOI":"10.1111\/all.14526","volume":"75","author":"H Hong","year":"2020","unstructured":"Hong H, Liao S, Chen F, Yang Q, Wang DY (2020) Role of IL-25, IL-33, and TSLP in triggering united airway diseases toward type 2 inflammation. Allergy 75(11):2794\u20132804. https:\/\/doi.org\/10.1111\/all.14526","journal-title":"Allergy"},{"issue":"11","key":"9073_CR5","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1002\/alr.22994","volume":"12","author":"P Gevaert","year":"2022","unstructured":"Gevaert P, Han JK, Smith SG, Sousa AR, Howarth PH, Yancey SW et al (2022) The roles of eosinophils and interleukin-5 in the pathophysiology of chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol 12(11):1413\u20131423. https:\/\/doi.org\/10.1002\/alr.22994","journal-title":"Int Forum Allergy Rhinol"},{"issue":"2","key":"9073_CR6","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/cea.14065","volume":"52","author":"Y Yao","year":"2021","unstructured":"Yao Y, Zeng M, Liu Z (2021) Revisiting Asian chronic rhinosinusitis in the era of type 2 biologics. Clin Exp Allergy 52(2):231\u2013243. https:\/\/doi.org\/10.1111\/cea.14065","journal-title":"Clin Exp Allergy"},{"issue":"9","key":"9073_CR7","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1038\/s41573-023-00750-1","volume":"22","author":"P Kolkhir","year":"2023","unstructured":"Kolkhir P, Akdis CA, Akdis M, Bachert C, Bieber T, Canonica GW et al (2023) Type 2 chronic inflammatory diseases: targets, therapies and unmet needs. Nat Rev Drug Discov 22(9):743\u2013767. https:\/\/doi.org\/10.1038\/s41573-023-00750-1","journal-title":"Nat Rev Drug Discov"},{"issue":"5","key":"9073_CR8","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/j.jaci.2021.07.034","volume":"148","author":"MA Kohanski","year":"2021","unstructured":"Kohanski MA, Cohen NA, Barrett NA (2021) Epithelial dysregulation in chronic rhinosinusitis with nasal polyposis (CRSwNP) and aspirin-exacerbated respiratory disease (AERD). J Allergy Clin Immunol 148(5):1161\u20131164. https:\/\/doi.org\/10.1016\/j.jaci.2021.07.034","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"9073_CR9","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1177\/1945892419868588","volume":"33","author":"M Wynne","year":"2019","unstructured":"Wynne M, Atkinson C, Schlosser RJ, Mulligan JK (2019) Contribution of epithelial cell dysfunction to the pathogenesis of chronic rhinosinusitis with nasal polyps. Am J Rhinol Allergy 33(6):782\u2013790. https:\/\/doi.org\/10.1177\/1945892419868588","journal-title":"Am J Rhinol Allergy"},{"issue":"4","key":"9073_CR10","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1172\/jci124606","volume":"129","author":"F Roan","year":"2019","unstructured":"Roan F, Obata-Ninomiya K, Ziegler SF (2019) Epithelial cell\u2013derived cytokines: more than just signaling the alarm. J Clin Invest 129(4):1441\u20131451. https:\/\/doi.org\/10.1172\/jci124606","journal-title":"J Clin Invest"},{"issue":"4","key":"9073_CR11","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.anai.2019.12.001","volume":"124","author":"TM Laidlaw","year":"2020","unstructured":"Laidlaw TM, Buchheit KM (2020) Biologics in chronic rhinosinusitis with nasal polyposis. Ann Allergy Asthma Immunol 124(4):326\u2013332. https:\/\/doi.org\/10.1016\/j.anai.2019.12.001","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"167","key":"9073_CR12","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0144-2022","volume":"32","author":"AA Calderon","year":"2023","unstructured":"Calderon AA, Dimond C, Choy DF, Pappu R, Grimbaldeston MA, Mohan D et al (2023) Targeting interleukin-33 and thymic stromal lymphopoietin pathways for novel pulmonary therapeutics in asthma and COPD. Eur Respir Rev 32(167):220144. https:\/\/doi.org\/10.1183\/16000617.0144-2022","journal-title":"Eur Respir Rev"},{"key":"9073_CR13","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/B978-0-12-404717-4.00004-4","volume":"66","author":"SF Ziegler","year":"2013","unstructured":"Ziegler SF, Roan F, Bell BD, Stoklasek TA, Kitajima M, Han H (2013) The biology of thymic stromal lymphopoietin (TSLP). Adv Pharmacol 66:129\u2013155. https:\/\/doi.org\/10.1016\/B978-0-12-404717-4.00004-4","journal-title":"Adv Pharmacol"},{"issue":"1","key":"9073_CR14","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.1749-6632.2009.05128.x","volume":"1183","author":"R He","year":"2010","unstructured":"He R, Geha RS (2010) Thymic stromal lymphopoietin. Ann N Y Acad Sci 1183(1):13\u201324. https:\/\/doi.org\/10.1111\/j.1749-6632.2009.05128.x","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"9073_CR15","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.jaci.2013.04.005","volume":"132","author":"DR Nagarkar","year":"2013","unstructured":"Nagarkar DR, Poposki JA, Tan BK, Comeau MR, Peters AT, Hulse KE et al (2013) Thymic stromal lymphopoietin activity is increased in nasal polyps of patients with chronic rhinosinusitis. J Allergy Clin Immunol 132(3):593-600.e12. https:\/\/doi.org\/10.1016\/j.jaci.2013.04.005","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"9073_CR16","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1016\/j.jaci.2016.08.040","volume":"139","author":"JA Poposki","year":"2017","unstructured":"Poposki JA, Klingler AI, Stevens WW, Peters AT, Hulse KE, Grammer LC et al (2017) Proprotein convertases generate a highly functional heterodimeric form of thymic stromal lymphopoietin in humans. J Allergy Clin Immunol 139(5):1559\u201367.e8. https:\/\/doi.org\/10.1016\/j.jaci.2016.08.040","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"9073_CR17","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1111\/cea.14552","volume":"55","author":"J Chen","year":"2025","unstructured":"Chen J, Hu L, Liu J, Zhang Q, Cheng F, Wang Y et al (2025) Association between preoperative nasal mucus thymic stromal lymphopoietin and decreased quality of life in chronic rhinosinusitis with nasal polyps. Clin Exp Allergy 55(5):413\u2013416. https:\/\/doi.org\/10.1111\/cea.14552","journal-title":"Clin Exp Allergy"},{"issue":"5","key":"9073_CR18","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/j.jaci.2022.11.029","volume":"151","author":"BF Wang","year":"2023","unstructured":"Wang BF, Cao PP, Norton JE, Poposki JA, Klingler AI, Suh LA et al (2023) Evidence that oncostatin M synergizes with IL-4 signaling to induce TSLP expression in chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 151(5):1379\u201390.e11. https:\/\/doi.org\/10.1016\/j.jaci.2022.11.029","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"9073_CR19","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1089\/jir.2015.0058","volume":"36","author":"H Kouzaki","year":"2016","unstructured":"Kouzaki H, Matsumoto K, Kato T, Tojima I, Shimizu S, Shimizu T (2016) Epithelial cell-derived cytokines contribute to the pathophysiology of eosinophilic chronic rhinosinusitis. J Interferon Cytokine Res 36(3):169\u2013179. https:\/\/doi.org\/10.1089\/jir.2015.0058","journal-title":"J Interferon Cytokine Res"},{"issue":"1","key":"9073_CR20","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/imr.12619","volume":"281","author":"C Cayrol","year":"2018","unstructured":"Cayrol C, Girard JP (2018) Interleukin-33 (IL-33): a nuclear cytokine from the IL-1 family. Immunol Rev 281(1):154\u2013168. https:\/\/doi.org\/10.1111\/imr.12619","journal-title":"Immunol Rev"},{"key":"9073_CR21","doi-asserted-by":"publisher","first-page":"364","DOI":"10.3389\/fimmu.2019.00364","volume":"10","author":"BCL Chan","year":"2019","unstructured":"Chan BCL, Lam CWK, Tam L-S, Wong CK (2019) IL33: roles in allergic inflammation and therapeutic perspectives. Front Immunol 10:364. https:\/\/doi.org\/10.3389\/fimmu.2019.00364","journal-title":"Front Immunol"},{"issue":"5","key":"9073_CR22","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","volume":"23","author":"J Schmitz","year":"2005","unstructured":"Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK et al (2005) IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23(5):479\u2013490. https:\/\/doi.org\/10.1016\/j.immuni.2005.09.015","journal-title":"Immunity"},{"issue":"4","key":"9073_CR23","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1002\/alr.22504","volume":"10","author":"R Huang","year":"2020","unstructured":"Huang R, Mao W, Wang G, Ding J, Sun Y, Gao G et al (2020) Synergistic relationship between TSLP and IL-33\/ST2 signaling pathways in allergic rhinitis and the effects of hypoxia. Int Forum Allergy Rhinol 10(4):511\u2013520. https:\/\/doi.org\/10.1002\/alr.22504","journal-title":"Int Forum Allergy Rhinol"},{"issue":"24","key":"9073_CR24","doi-asserted-by":"publisher","first-page":"7537","DOI":"10.3390\/jcm12247537","volume":"12","author":"IM Porfire","year":"2023","unstructured":"Porfire IM, Berindan-Neagoe I, Budisan L, Leucuta D-C, Gata A, Minoiu AC et al (2023) Tissue interleukin-33: a novel potential regulator of innate immunity and biomarker of disease severity in chronic rhinosinusitis with nasal polyps. J Clin Med 12(24):7537. https:\/\/doi.org\/10.3390\/jcm12247537","journal-title":"J Clin Med"},{"issue":"4","key":"9073_CR25","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1177\/1945892419835333","volume":"33","author":"Y Nagata","year":"2019","unstructured":"Nagata Y, Maruoka S, Gon Y, Mizumura K, Kishi H, Nomura Y et al (2019) Expression of IL-25, IL-33, and thymic stromal lymphopoietin in nasal polyp gland duct epithelium in patients with chronic rhinosinusitis. Am J Rhinol Allergy 33(4):378\u2013387. https:\/\/doi.org\/10.1177\/1945892419835333","journal-title":"Am J Rhinol Allergy"},{"key":"9073_CR26","doi-asserted-by":"publisher","first-page":"9155080","DOI":"10.1155\/2022\/9155080","volume":"2022","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Zhu K, Chen J, Xia C, Yu C, Gao T et al (2022) Predictive values of serum IL-33 and sST2 in endotypes and postoperative recurrence of chronic rhinosinusitis with nasal polyps. Mediators Inflamm 2022:9155080. https:\/\/doi.org\/10.1155\/2022\/9155080","journal-title":"Mediators Inflamm"},{"issue":"1","key":"9073_CR27","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12865-022-00507-2","volume":"23","author":"H Zieli\u0144ska-Bli\u017aniewska","year":"2022","unstructured":"Zieli\u0144ska-Bli\u017aniewska H, Paprocka-Zjawiona M, Merecz-Sadowska A, Zajdel R, Bli\u017aniewska-Kowalska K, Malinowska K (2022) Serum IL-5, POSTN and IL-33 levels in chronic rhinosinusitis with nasal polyposis correlate with clinical severity. BMC Immunol 23(1):33. https:\/\/doi.org\/10.1186\/s12865-022-00507-2","journal-title":"BMC Immunol"},{"issue":"7","key":"9073_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011450","volume":"5","author":"T Means","year":"2010","unstructured":"Means T, Plager DA, Kahl JC, Asmann YW, Nilson AE, Pallanch JF et al (2010) Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis. PLoS ONE 5(7):e11450. https:\/\/doi.org\/10.1371\/journal.pone.0011450","journal-title":"PLoS ONE"},{"issue":"4","key":"9073_CR29","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1164\/rccm.201212-2227OC","volume":"188","author":"JL Shaw","year":"2013","unstructured":"Shaw JL, Fakhri S, Citardi MJ, Porter PC, Corry DB, Kheradmand F et al (2013) IL-33-responsive innate lymphoid cells are an important source of IL-13 in chronic rhinosinusitis with nasal polyps. Am J Respir Crit Care Med 188(4):432\u2013439. https:\/\/doi.org\/10.1164\/rccm.201212-2227OC","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"9073_CR30","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1002\/alr.21082","volume":"3","author":"M Lam","year":"2013","unstructured":"Lam M, Hull L, McLachlan R, Snidvongs K, Chin D, Pratt E et al (2013) Clinical severity and epithelial endotypes in chronic rhinosinusitis. Int Forum Allergy Rhinol 3(2):121\u2013128. https:\/\/doi.org\/10.1002\/alr.21082","journal-title":"Int Forum Allergy Rhinol"},{"issue":"4","key":"9073_CR31","doi-asserted-by":"publisher","first-page":"E115","DOI":"10.1002\/lary.24462","volume":"124","author":"S Baba","year":"2013","unstructured":"Baba S, Kondo K, Kanaya K, Suzukawa K, Ushio M, Urata S et al (2013) Expression of IL-33 and its receptor ST2 in chronic rhinosinusitis with nasal polyps. Laryngoscope 124(4):E115\u2013E122. https:\/\/doi.org\/10.1002\/lary.24462","journal-title":"Laryngoscope"},{"issue":"5","key":"9073_CR32","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1111\/j.1398-9995.2009.02227.x","volume":"65","author":"ID Buysschaert","year":"2010","unstructured":"Buysschaert ID, Grulois V, Eloy P, Jorissen M, Rombaux P, Bertrand B et al (2010) Genetic evidence for a role of IL33 in nasal polyposis. Allergy 65(5):616\u2013622. https:\/\/doi.org\/10.1111\/j.1398-9995.2009.02227.x","journal-title":"Allergy"},{"issue":"4","key":"9073_CR33","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1073\/pnas.1014241108","volume":"108","author":"CJ Corrigan","year":"2011","unstructured":"Corrigan CJ, Wang W, Meng Q, Fang C, Wu H, Reay V et al (2011) T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma. Proc Natl Acad Sci U S A 108(4):1579\u20131584. https:\/\/doi.org\/10.1073\/pnas.1014241108","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"9073_CR34","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.immuni.2019.03.021","volume":"50","author":"MJ McGeachy","year":"2019","unstructured":"McGeachy MJ, Cua DJ, Gaffen SL (2019) The IL-17 family of cytokines in health and disease. Immunity 50(4):892\u2013906. https:\/\/doi.org\/10.1016\/j.immuni.2019.03.021","journal-title":"Immunity"},{"issue":"1","key":"9073_CR35","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s40364-023-00474-9","volume":"11","author":"Q Yuan","year":"2023","unstructured":"Yuan Q, Peng N, Xiao F, Shi X, Zhu B, Rui K et al (2023) New insights into the function of interleukin-25 in disease pathogenesis. Biomark Res 11(1):36. https:\/\/doi.org\/10.1186\/s40364-023-00474-9","journal-title":"Biomark Res"},{"key":"9073_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.691559","volume":"12","author":"C Deng","year":"2021","unstructured":"Deng C, Peng N, Tang Y, Yu N, Wang C, Cai X et al (2021) Roles of IL-25 in type 2 inflammation and autoimmune pathogenesis. Front Immunol 12:691559. https:\/\/doi.org\/10.3389\/fimmu.2021.691559","journal-title":"Front Immunol"},{"issue":"10","key":"9073_CR37","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1038\/aps.2013.88","volume":"34","author":"S-h He","year":"2013","unstructured":"He S-h, Zhang H-y, Zeng X-n, Chen D, Yang P-c (2013) Mast cells and basophils are essential for allergies: mechanisms of allergic inflammation and a proposed procedure for diagnosis. Acta Pharmacol Sin 34(10):1270\u201383. https:\/\/doi.org\/10.1038\/aps.2013.88","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"9073_CR38","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jaci.2020.12.628","volume":"148","author":"J Borowczyk","year":"2021","unstructured":"Borowczyk J, Shutova M, Brembilla NC, Boehncke W-H (2021) IL-25 (IL-17E) in epithelial immunology and pathophysiology. J Allergy Clin Immunol 148(1):40\u201352. https:\/\/doi.org\/10.1016\/j.jaci.2020.12.628","journal-title":"J Allergy Clin Immunol"},{"key":"9073_CR39","doi-asserted-by":"publisher","unstructured":"Patel NN, Kohanski MA, Maina IW, Triantafillou V, Workman AD, Tong CCL et al (2019) Solitary chemosensory cells producing IL-25 and group-2 innate lymphoid cells are enriched in chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol 900\u20136. https:\/\/doi.org\/10.1002\/alr.22142","DOI":"10.1002\/alr.22142"},{"issue":"2","key":"9073_CR40","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.jaci.2023.03.023","volume":"152","author":"WE LeSuer","year":"2023","unstructured":"LeSuer WE, Kienzl M, Ochkur SI, Schicho R, Doyle AD, Wright BL et al (2023) Eosinophils promote effector functions of lung group 2 innate lymphoid cells in allergic airway inflammation in mice. J Allergy Clin Immunol 152(2):469\u201385.e10. https:\/\/doi.org\/10.1016\/j.jaci.2023.03.023","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"9073_CR41","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1016\/j.jaci.2015.01.003","volume":"135","author":"HW Shin","year":"2015","unstructured":"Shin HW, Kim DK, Park MH, Eun KM, Lee M, So D et al (2015) IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis. J Allergy Clin Immunol 135(6):1476\u201385.e7. https:\/\/doi.org\/10.1016\/j.jaci.2015.01.003","journal-title":"J Allergy Clin Immunol"},{"issue":"13","key":"9073_CR42","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.1084\/jem.20130351","volume":"210","author":"M Salimi","year":"2013","unstructured":"Salimi M, Barlow JL, Saunders SP, Xue L, Gutowska-Owsiak D, Wang X et al (2013) A role for IL-25 and IL-33\u2013driven type-2 innate lymphoid cells in atopic dermatitis. J Exp Med 210(13):2939\u20132950. https:\/\/doi.org\/10.1084\/jem.20130351","journal-title":"J Exp Med"},{"issue":"1","key":"9073_CR43","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1186\/s12964-023-01347-2","volume":"21","author":"Z Chegini","year":"2023","unstructured":"Chegini Z, Noei M, Hemmati J, Arabestani MR, Shariati A (2023) The destruction of mucosal barriers, epithelial remodeling, and impaired mucociliary clearance: possible pathogenic mechanisms of Pseudomonas aeruginosa and Staphylococcus aureus in chronic rhinosinusitis. Cell Commun Signal 21(1):306. https:\/\/doi.org\/10.1186\/s12964-023-01347-2","journal-title":"Cell Commun Signal"},{"issue":"5","key":"9073_CR44","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1159\/000528969","volume":"184","author":"R Zhang","year":"2023","unstructured":"Zhang R, Zhang L, Li P, Pang K, Liu H, Tian L (2023) Epithelial barrier in the nasal mucosa, related risk factors and diseases. Int Arch Allergy Immunol 184(5):481\u2013501. https:\/\/doi.org\/10.1159\/000528969","journal-title":"Int Arch Allergy Immunol"},{"issue":"2","key":"9073_CR45","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s11882-014-0495-8","volume":"15","author":"S Toppila-Salmi","year":"2014","unstructured":"Toppila-Salmi S, van Drunen CM, Fokkens WJ, Golebski K, Mattila P, Joenvaara S et al (2014) Molecular mechanisms of nasal epithelium in rhinitis and rhinosinusitis. Curr Allergy Asthma Rep 15(2):495. https:\/\/doi.org\/10.1007\/s11882-014-0495-8","journal-title":"Curr Allergy Asthma Rep"},{"issue":"3","key":"9073_CR46","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/all.12809","volume":"71","author":"N Zhang","year":"2016","unstructured":"Zhang N, Van Crombruggen K, Gevaert E, Bachert C (2016) Barrier function of the nasal mucosa in health and type-2 biased airway diseases. Allergy 71(3):295\u2013307. https:\/\/doi.org\/10.1111\/all.12809","journal-title":"Allergy"},{"key":"9073_CR47","doi-asserted-by":"publisher","unstructured":"Shin SH, Ye MK, Lee DW, Chae MH, Han BD (2020) Nasal epithelial cells activated with alternaria and house dust mite induce not only Th2 but also Th1 immune responses. Int J Mol Sci 21(8). https:\/\/doi.org\/10.3390\/ijms21082693","DOI":"10.3390\/ijms21082693"},{"key":"9073_CR48","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.molimm.2023.03.002","volume":"156","author":"A Jacquet","year":"2023","unstructured":"Jacquet A (2023) The HDM allergen orchestra and its cysteine protease maestro: stimulators of kaleidoscopic innate immune responses. Mol Immunol 156:48\u201360. https:\/\/doi.org\/10.1016\/j.molimm.2023.03.002","journal-title":"Mol Immunol"},{"issue":"5","key":"9073_CR49","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1111\/all.15678","volume":"78","author":"WT Soh","year":"2023","unstructured":"Soh WT, Zhang J, Hollenberg MD, Vliagoftis H, Rothenberg ME, Sokol CL et al (2023) Protease allergens as initiators\u2013regulators of allergic inflammation. Allergy 78(5):1148\u20131168. https:\/\/doi.org\/10.1111\/all.15678","journal-title":"Allergy"},{"issue":"1","key":"9073_CR50","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1097\/aci.0000000000000332","volume":"17","author":"M Lee","year":"2017","unstructured":"Lee M, Kim DW, Shin H-W (2017) Targeting IL-25 as a novel therapy in chronic rhinosinusitis with nasal polyps. Curr Opin Allergy Clin Immunol 17(1):17\u201322. https:\/\/doi.org\/10.1097\/aci.0000000000000332","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"3","key":"9073_CR51","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1111\/all.12329","volume":"69","author":"I Mahmutovic-Persson","year":"2014","unstructured":"Mahmutovic-Persson I, Akbarshahi H, Bartlett NW, Glanville N, Johnston SL, Brandelius A et al (2014) Inhaled dsRNA and rhinovirus evoke neutrophilic exacerbation and lung expression of thymic stromal lymphopoietin in allergic mice with established experimental asthma. Allergy 69(3):348\u2013358. https:\/\/doi.org\/10.1111\/all.12329","journal-title":"Allergy"},{"key":"9073_CR52","doi-asserted-by":"publisher","unstructured":"Kato A, Jr. SF, Avila PC, Schleimer RP (2007) TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells. J Immunol 179(2):1080\u20137. https:\/\/doi.org\/10.4049\/jimmunol.179.2.1080","DOI":"10.4049\/jimmunol.179.2.1080"},{"issue":"2","key":"9073_CR53","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.alit.2016.06.011","volume":"66","author":"T Kato","year":"2017","unstructured":"Kato T, Kouzaki H, Matsumoto K, Hosoi J, Shimizu T (2017) The effect of calprotectin on TSLP and IL-25 production from airway epithelial cells. Allergol Int 66(2):281\u2013289. https:\/\/doi.org\/10.1016\/j.alit.2016.06.011","journal-title":"Allergol Int"},{"key":"9073_CR54","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110559","volume":"121","author":"M Zhang","year":"2023","unstructured":"Zhang M, Tang B, Huang L, Xiong Y, Tu J, Jia Y et al (2023) Hypoxia induces the production of epithelial-derived cytokines in eosinophilic chronic rhinosinusitis with nasal polyps. Int Immunopharmacol 121:110559. https:\/\/doi.org\/10.1016\/j.intimp.2023.110559","journal-title":"Int Immunopharmacol"},{"key":"9073_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.530488","volume":"12","author":"R Liu","year":"2021","unstructured":"Liu R, Du J, Zhou J, Zhong B, Ba L, Zhang J et al (2021) Elevated microRNA-21 is a brake of inflammation involved in the development of nasal polyps. Front Immunol 12:530488. https:\/\/doi.org\/10.3389\/fimmu.2021.530488","journal-title":"Front Immunol"},{"issue":"2","key":"9073_CR56","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.788","volume":"11","author":"MJ Gong","year":"2023","unstructured":"Gong MJ, Zhang HB, Lou M, Wang YS, Ma RP, Hu ZZ et al (2023) Melatonin reduces IL-33 and TSLP expression in human nasal epithelial cells by scavenging ROS directly. Immun Inflamm Dis 11(2):e788. https:\/\/doi.org\/10.1002\/iid3.788","journal-title":"Immun Inflamm Dis"},{"issue":"6","key":"9073_CR57","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1016\/j.jaci.2022.07.003","volume":"150","author":"AG Stanbery","year":"2022","unstructured":"Stanbery AG, Shuchi S, von Jakob M, Tait Wojno ED, Ziegler SF (2022) TSLP, IL-33, and IL-25: not just for allergy and helminth infection. J Allergy Clin Immunol 150(6):1302\u20131313. https:\/\/doi.org\/10.1016\/j.jaci.2022.07.003","journal-title":"J Allergy Clin Immunol"},{"key":"9073_CR58","doi-asserted-by":"publisher","first-page":"309","DOI":"10.2147\/jir.S180853","volume":"12","author":"A Scherzad","year":"2019","unstructured":"Scherzad A, Hagen R, Hackenberg S (2019) Current understanding of nasal epithelial cell mis-differentiation. J Inflamm Res 12:309\u2013317. https:\/\/doi.org\/10.2147\/jir.S180853","journal-title":"J Inflamm Res"},{"issue":"6","key":"9073_CR59","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1016\/j.jaci.2020.04.024","volume":"145","author":"Z Celebi S\u00f6zener","year":"2020","unstructured":"Celebi S\u00f6zener Z, Cevhertas L, Nadeau K, Akdis M, Akdis CA (2020) Environmental factors in epithelial barrier dysfunction. J Allergy Clin Immunol 145(6):1517\u20131528. https:\/\/doi.org\/10.1016\/j.jaci.2020.04.024","journal-title":"J Allergy Clin Immunol"},{"issue":"10","key":"9073_CR60","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1038\/s41590-022-01312-0","volume":"23","author":"W Wang","year":"2022","unstructured":"Wang W, Xu Y, Wang L, Zhu Z, Aodeng S, Chen H et al (2022) Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis. Nat Immunol 23(10):1484\u20131494. https:\/\/doi.org\/10.1038\/s41590-022-01312-0","journal-title":"Nat Immunol"},{"issue":"6","key":"9073_CR61","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1016\/j.jaci.2023.01.030","volume":"151","author":"X Wang","year":"2023","unstructured":"Wang X, Hallen NR, Lee M, Samuchiwal S, Ye Q, Buchheit KM et al (2023) Type 2 inflammation drives an airway basal stem cell program through insulin receptor substrate signaling. J Allergy Clin Immunol 151(6):1536\u20131549. https:\/\/doi.org\/10.1016\/j.jaci.2023.01.030","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"9073_CR62","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s00441-009-0855-1","volume":"338","author":"R Kamekura","year":"2009","unstructured":"Kamekura R, Kojima T, Koizumi J, Ogasawara N, Kurose M, Go M et al (2009) Thymic stromal lymphopoietin enhances tight-junction barrier function of human nasal epithelial cells. Cell Tissue Res 338(2):283\u2013293. https:\/\/doi.org\/10.1007\/s00441-009-0855-1","journal-title":"Cell Tissue Res"},{"key":"9073_CR63","doi-asserted-by":"publisher","first-page":"39559","DOI":"10.1038\/srep39559","volume":"6","author":"H Dong","year":"2016","unstructured":"Dong H, Hu Y, Liu L, Zou M, Huang C, Luo L et al (2016) Distinct roles of short and long thymic stromal lymphopoietin isoforms in house dust mite-induced asthmatic airway epithelial barrier disruption. Sci Rep 6:39559. https:\/\/doi.org\/10.1038\/srep39559","journal-title":"Sci Rep"},{"issue":"7","key":"9073_CR64","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1136\/thoraxjnl-2016-208772","volume":"72","author":"DK Kim","year":"2017","unstructured":"Kim DK, Jin HR, Eun KM, Mo JH, Cho SH, Oh S et al (2017) The role of interleukin-33 in chronic rhinosinusitis. Thorax 72(7):635\u2013645. https:\/\/doi.org\/10.1136\/thoraxjnl-2016-208772","journal-title":"Thorax"},{"issue":"2","key":"9073_CR65","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.jaci.2018.03.019","volume":"142","author":"MA Kohanski","year":"2018","unstructured":"Kohanski MA, Workman AD, Patel NN, Hung L-Y, Shtraks JP, Chen B et al (2018) Solitary chemosensory cells are a primary epithelial source of IL-25 in patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 142(2):460\u20139.e7. https:\/\/doi.org\/10.1016\/j.jaci.2018.03.019","journal-title":"J Allergy Clin Immunol"},{"key":"9073_CR66","doi-asserted-by":"publisher","unstructured":"Neil N, Patel BB, Michael A (2019) Kohanski. Solitary chemosensory cells producing IL-25 and group-2 innate lymphoid cells are enriched in chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol 8(8):900\u20136. https:\/\/doi.org\/10.1002\/alr.22142","DOI":"10.1002\/alr.22142"},{"issue":"2","key":"9073_CR67","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1111\/all.13267","volume":"73","author":"HY Hong","year":"2018","unstructured":"Hong HY, Chen FH, Sun YQ, Hu XT, Wei Y, Fan YP et al (2018) Local IL-25 contributes to Th2-biased inflammatory profiles in nasal polyps. Allergy 73(2):459\u2013469. https:\/\/doi.org\/10.1111\/all.13267","journal-title":"Allergy"},{"key":"9073_CR68","doi-asserted-by":"publisher","unstructured":"Ryu G, Kim HY, Jung YG, Hong SD (2022) Endotypes of Asian chronic rhinosinusitis with nasal polyps: a narrative review. Precis Future Med 6(3):170\u20136. https:\/\/doi.org\/10.23838\/pfm.2022.00072","DOI":"10.23838\/pfm.2022.00072"},{"issue":"9","key":"9073_CR69","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1111\/all.12667","volume":"70","author":"B Liao","year":"2015","unstructured":"Liao B, Cao PP, Zeng M, Zhen Z, Wang H, Zhang YN et al (2015) Interaction of thymic stromal lymphopoietin, IL-33, and their receptors in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps. Allergy 70(9):1169\u20131180. https:\/\/doi.org\/10.1111\/all.12667","journal-title":"Allergy"},{"issue":"5","key":"9073_CR70","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.mucimm.2023.07.002","volume":"16","author":"B Curren","year":"2023","unstructured":"Curren B, Ahmed T, Howard DR, Ashik Ullah M, Sebina I, Rashid RB et al (2023) IL-33-induced neutrophilic inflammation and NETosis underlie rhinovirus-triggered exacerbations of asthma. Mucosal Immunol 16(5):671\u2013684. https:\/\/doi.org\/10.1016\/j.mucimm.2023.07.002","journal-title":"Mucosal Immunol"},{"issue":"4","key":"9073_CR71","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/s41385-020-0266-x","volume":"13","author":"H Kabata","year":"2020","unstructured":"Kabata H, Flamar AL, Mahlak\u00f5iv T, Moriyama S, Rodewald HR, Ziegler SF et al (2020) Targeted deletion of the TSLP receptor reveals cellular mechanisms that promote type 2 airway inflammation. Mucosal Immunol 13(4):626\u2013636. https:\/\/doi.org\/10.1038\/s41385-020-0266-x","journal-title":"Mucosal Immunol"},{"issue":"1","key":"9073_CR72","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/s41577-022-00735-y","volume":"23","author":"R Ebina-Shibuya","year":"2023","unstructured":"Ebina-Shibuya R, Leonard WJ (2023) Role of thymic stromal lymphopoietin in allergy and beyond. Nat Rev Immunol 23(1):24\u201337. https:\/\/doi.org\/10.1038\/s41577-022-00735-y","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"9073_CR73","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.3390\/cells9091944","volume":"9","author":"M Paplinska-Goryca","year":"2020","unstructured":"Paplinska-Goryca M, Misiukiewicz-Stepien P, Proboszcz M, Nejman-Gryz P, Gorska K, Krenke R (2020) The expressions of TSLP, IL-33, and IL-17A in monocyte derived dendritic cells from asthma and COPD patients are related to epithelial-macrophage interactions. Cells 9(9):1944. https:\/\/doi.org\/10.3390\/cells9091944","journal-title":"Cells"},{"issue":"9","key":"9073_CR74","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1084\/jem.20051135","volume":"202","author":"T Ito","year":"2005","unstructured":"Ito T, Wang YH, Duramad O, Hori T, Delespesse GJ, Watanabe N et al (2005) TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J Exp Med 202(9):1213\u20131223. https:\/\/doi.org\/10.1084\/jem.20051135","journal-title":"J Exp Med"},{"issue":"5","key":"9073_CR75","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1586\/eci.09.45","volume":"5","author":"MM Miazgowicz","year":"2014","unstructured":"Miazgowicz MM, Headley MB, Larson RP, Ziegler SF (2014) Thymic stromal lymphopoietin and the pathophysiology of atopic disease. Expert Rev Clin Immunol 5(5):547\u2013556. https:\/\/doi.org\/10.1586\/eci.09.45","journal-title":"Expert Rev Clin Immunol"},{"issue":"5","key":"9073_CR76","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.jaci.2009.02.026","volume":"123","author":"MA Rank","year":"2009","unstructured":"Rank MA, Kobayashi T, Kozaki H, Bartemes KR, Squillace DL, Kita H (2009) IL-33\u2013activated dendritic cells induce an atypical TH2-type response. J Allergy Clin Immunol 123(5):1047\u20131054. https:\/\/doi.org\/10.1016\/j.jaci.2009.02.026","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"9073_CR77","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.anai.2020.08.001","volume":"126","author":"WW Stevens","year":"2021","unstructured":"Stevens WW, Kato A (2021) Group 2 innate lymphoid cells in nasal polyposis. Ann Allergy Asthma Immunol 126(2):110\u2013117. https:\/\/doi.org\/10.1016\/j.anai.2020.08.001","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"9073_CR78","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1111\/cea.12462","volume":"45","author":"J Ho","year":"2015","unstructured":"Ho J, Bailey M, Zaunders J, Mrad N, Sacks R, Sewell W et al (2015) Group 2 innate lymphoid cells (ILC2s) are increased in chronic rhinosinusitis with nasal polyps or eosinophilia. Clin Exp Allergy 45(2):394\u2013403. https:\/\/doi.org\/10.1111\/cea.12462","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"9073_CR79","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.mucimm.2022.11.002","volume":"16","author":"MM McDaniel","year":"2023","unstructured":"McDaniel MM, Lara HI, von Moltke J (2023) Initiation of type 2 immunity at barrier surfaces. Mucosal Immunol 16(1):86\u201397. https:\/\/doi.org\/10.1016\/j.mucimm.2022.11.002","journal-title":"Mucosal Immunol"},{"issue":"7","key":"9073_CR80","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1111\/all.14196","volume":"75","author":"S Toki","year":"2020","unstructured":"Toki S, Goleniewska K, Zhang J, Zhou W, Newcomb DC, Zhou B et al (2020) TSLP and IL-33 reciprocally promote each other\u2019s lung protein expression and ILC2 receptor expression to enhance innate type-2 airway inflammation. Allergy 75(7):1606\u20131617. https:\/\/doi.org\/10.1111\/all.14196","journal-title":"Allergy"},{"issue":"1","key":"9073_CR81","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s41385-019-0215-8","volume":"13","author":"N Ogasawara","year":"2020","unstructured":"Ogasawara N, Poposki JA, Klingler AI, Tan BK, Hulse KE, Stevens WW et al (2020) Role of RANK-L as a potential inducer of ILC2-mediated type 2 inflammation in chronic rhinosinusitis with nasal polyps. Mucosal Immunol 13(1):86\u201395. https:\/\/doi.org\/10.1038\/s41385-019-0215-8","journal-title":"Mucosal Immunol"},{"issue":"12","key":"9073_CR82","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1164\/rccm.201406-1039OC","volume":"190","author":"DJ Jackson","year":"2014","unstructured":"Jackson DJ, Makrinioti H, Rana BMJ, Shamji BWH, Trujillo-Torralbo M-B, Footitt J et al (2014) IL-33\u2013dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo. Am J Respir Crit Care Med 190(12):1373\u20131382. https:\/\/doi.org\/10.1164\/rccm.201406-1039OC","journal-title":"Am J Respir Crit Care Med"},{"key":"9073_CR83","doi-asserted-by":"publisher","first-page":"1062412","DOI":"10.3389\/falgy.2022.1062412","volume":"3","author":"S Trivedi","year":"2022","unstructured":"Trivedi S, Labuz D, Deering-Rice CE, Kim CU, Christensen H, Aamodt S et al (2022) IL-33 induces NF-\u03baB activation in ILC2 that can be suppressed by in vivo and ex vivo 17\u03b2-estradiol. Front Allergy 3:1062412. https:\/\/doi.org\/10.3389\/falgy.2022.1062412","journal-title":"Front Allergy"},{"issue":"1","key":"9073_CR84","doi-asserted-by":"publisher","first-page":"3479","DOI":"10.1038\/s41598-020-60089-0","volume":"10","author":"T Petrova","year":"2020","unstructured":"Petrova T, Pesic J, Pardali K, Gaestel M, Arthur JSC (2020) p38 MAPK signalling regulates cytokine production in IL-33 stimulated type 2 innate lymphoid cells. Sci Rep 10(1):3479. https:\/\/doi.org\/10.1038\/s41598-020-60089-0","journal-title":"Sci Rep"},{"issue":"6","key":"9073_CR85","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12265","volume":"13","author":"F Sun","year":"2023","unstructured":"Sun F, Zou W, Shi H, Chen Z, Ma D, Lin M et al (2023) Interleukin-33 increases type 2 innate lymphoid cell count and their activation in eosinophilic asthma. Clin Transl Allergy 13(6):e12265. https:\/\/doi.org\/10.1002\/clt2.12265","journal-title":"Clin Transl Allergy"},{"key":"9073_CR86","doi-asserted-by":"publisher","unstructured":"Ploeg EKv, Golebski K, Nimwegen Mv, Fergusson JR, Heesters BA, Martinez-Gonzalez I et al (2021) Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases. Sci Immunol 6(55):eabd3489. https:\/\/doi.org\/10.1126\/sciimmunol.abd3489","DOI":"10.1126\/sciimmunol.abd3489"},{"issue":"2","key":"9073_CR87","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1084\/jem.20062211","volume":"204","author":"Z Allakhverdi","year":"2007","unstructured":"Allakhverdi Z, Comeau MR, Jessup HK, Yoon BR, Brewer A, Chartier S et al (2007) Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J Exp Med 204(2):253\u2013258. https:\/\/doi.org\/10.1084\/jem.20062211","journal-title":"J Exp Med"},{"issue":"5","key":"9073_CR88","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1016\/j.jaci.2015.10.020","volume":"137","author":"KM Buchheit","year":"2016","unstructured":"Buchheit KM, Cahill KN, Katz HR, Murphy KC, Feng C, Lee-Sarwar K et al (2016) Thymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol 137(5):1566\u201376.e5. https:\/\/doi.org\/10.1016\/j.jaci.2015.10.020","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"9073_CR89","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1016\/j.jaci.2008.04.005","volume":"121","author":"WB Cherry","year":"2008","unstructured":"Cherry WB, Yoon J, Bartemes KR, Iijima K, Kita H (2008) A novel IL-1 family cytokine, IL-33, potently activates human eosinophils. J Allergy Clin Immunol 121(6):1484\u20131490. https:\/\/doi.org\/10.1016\/j.jaci.2008.04.005","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"9073_CR90","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.jaci.2012.02.013","volume":"130","author":"Y Haenuki","year":"2012","unstructured":"Haenuki Y, Matsushita K, Futatsugi-Yumikura S, Ishii KJ, Kawagoe T, Imoto Y et al (2012) A critical role of IL-33 in experimental allergic rhinitis. J Allergy Clin Immunol 130(1):184\u201394.e11. https:\/\/doi.org\/10.1016\/j.jaci.2012.02.013","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"9073_CR91","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1016\/j.jaci.2015.10.019","volume":"137","author":"EP Lam","year":"2016","unstructured":"Lam EP, Kariyawasam HH, Rana BM, Durham SR, McKenzie AN, Powell N et al (2016) IL-25\/IL-33-responsive TH2 cells characterize nasal polyps with a default TH17 signature in nasal mucosa. J Allergy Clin Immunol 137(5):1514\u20131524. https:\/\/doi.org\/10.1016\/j.jaci.2015.10.019","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"9073_CR92","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.anai.2015.01.013","volume":"114","author":"T Iinuma","year":"2015","unstructured":"Iinuma T, Okamoto Y, Yamamoto H, Inamine-Sasaki A, Ohki Y, Sakurai T et al (2015) Interleukin-25 and mucosal T cells in noneosinophilic and eosinophilic chronic rhinosinusitis. Ann Allergy Asthma Immunol 114(4):289\u2013298. https:\/\/doi.org\/10.1016\/j.anai.2015.01.013","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"9073_CR93","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1111\/all.15609","volume":"78","author":"GM Gauvreau","year":"2023","unstructured":"Gauvreau GM, Bergeron C, Boulet LP, Cockcroft DW, C\u00f4t\u00e9 A, Davis BE et al (2023) Sounding the alarmins-the role of alarmin cytokines in asthma. Allergy 78(2):402\u2013417. https:\/\/doi.org\/10.1111\/all.15609","journal-title":"Allergy"},{"issue":"1","key":"9073_CR94","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s11882-024-01186-2","volume":"25","author":"E De Corso","year":"2024","unstructured":"De Corso E, Hellings PW, Fokkens WJ, Klimek L, Peters AT, Scadding GK et al (2024) Thymic stromal lymphopoietin (TSLP): evidence in respiratory epithelial-driven diseases including chronic rhinosinusitis with nasal polyps. Curr Allergy Asthma Rep 25(1):7. https:\/\/doi.org\/10.1007\/s11882-024-01186-2","journal-title":"Curr Allergy Asthma Rep"},{"key":"9073_CR95","unstructured":"AstraZeneca. Tezspire (tezepelumab) approved in the US for severe asthma 2023 [Available from: https:\/\/www.astrazeneca.com\/media-centre\/press-releases\/2021\/Tezspire-tezepelumab-approved-in-the-us-for-severe-asthma.html."},{"issue":"11","key":"9073_CR96","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1080\/13543784.2019.1672657","volume":"28","author":"G Marone","year":"2019","unstructured":"Marone G, Spadaro G, Braile M, Poto R, Criscuolo G, Pahima H et al (2019) Tezepelumab: a novel biological therapy for the treatment of severe uncontrolled asthma. Expert Opin Investig Drugs 28(11):931\u2013940. https:\/\/doi.org\/10.1080\/13543784.2019.1672657","journal-title":"Expert Opin Investig Drugs"},{"issue":"6","key":"9073_CR97","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1111\/all.15197","volume":"77","author":"J Corren","year":"2022","unstructured":"Corren J, Pham TH, Garcia Gil E, Sa\u0142apa K, Ren P, Parnes JR et al (2022) Baseline type 2 biomarker levels and response to tezepelumab in severe asthma. Allergy 77(6):1786\u20131796. https:\/\/doi.org\/10.1111\/all.15197","journal-title":"Allergy"},{"issue":"12","key":"9073_CR98","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1056\/NEJMoa2414482","volume":"392","author":"BJ Lipworth","year":"2025","unstructured":"Lipworth BJ, Han JK, Desrosiers M, Hopkins C, Lee SE, Mullol J et al (2025) Tezepelumab in adults with severe chronic rhinosinusitis with nasal polyps. N Engl J Med 392(12):1178\u20131188. https:\/\/doi.org\/10.1056\/NEJMoa2414482","journal-title":"N Engl J Med"},{"key":"9073_CR99","doi-asserted-by":"publisher","first-page":"915","DOI":"10.2147\/jaa.S413064","volume":"16","author":"TM Laidlaw","year":"2023","unstructured":"Laidlaw TM, Menzies-Gow A, Caveney S, Han JK, Martin N, Israel E et al (2023) Tezepelumab efficacy in patients with severe, uncontrolled asthma with comorbid nasal polyps in NAVIGATOR. J Asthma Allergy 16:915\u2013932. https:\/\/doi.org\/10.2147\/jaa.S413064","journal-title":"J Asthma Allergy"},{"issue":"5","key":"9073_CR100","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1016\/j.jaci.2024.01.015","volume":"153","author":"B Yan","year":"2024","unstructured":"Yan B, Lan F, Li J, Wang C, Zhang L (2024) The mucosal concept in chronic rhinosinusitis: focus on the epithelial barrier. J Allergy Clin Immunol 153(5):1206\u20131214. https:\/\/doi.org\/10.1016\/j.jaci.2024.01.015","journal-title":"J Allergy Clin Immunol"},{"key":"9073_CR101","doi-asserted-by":"publisher","unstructured":"Klironomou A, Papaiakovou G, Bakakos A, Anagnostopoulos N, Koukaki E, Theofani E et al (2024) Tezepelumab: a promising therapy for severe uncontrolled asthma. Explor Asthma Allergy 2:485\u2013501. https:\/\/doi.org\/10.37349\/eaa","DOI":"10.37349\/eaa"},{"issue":"10","key":"9073_CR102","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1111\/all.12469","volume":"69","author":"K Yadava","year":"2014","unstructured":"Yadava K, Massacand J, Mosconi I, Nicod LP, Harris NL, Marsland BJ (2014) Thymic stromal lymphopoietin plays divergent roles in murine models of atopic and nonatopic airway inflammation. Allergy 69(10):1333\u20131342. https:\/\/doi.org\/10.1111\/all.12469","journal-title":"Allergy"},{"key":"9073_CR103","unstructured":"Randazzo B (2019) Proof of concept study to investigate etokimab (ANB020) activity in adult participants with severe eosinophilic asthma. ClinicalTrials.gov. Report No.: NCT03469934."},{"issue":"18","key":"9073_CR104","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1056\/NEJMoa2024257","volume":"385","author":"ME Wechsler","year":"2021","unstructured":"Wechsler ME, Ruddy MK, Pavord ID, Israel E, Rabe KF, Ford LB et al (2021) Efficacy and safety of itepekimab in patients with moderate-to-severe asthma. N Engl J Med 385(18):1656\u20131668. https:\/\/doi.org\/10.1056\/NEJMoa2024257","journal-title":"N Engl J Med"},{"issue":"3","key":"9073_CR105","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.jaci.2021.03.044","volume":"148","author":"SG Kelsen","year":"2021","unstructured":"Kelsen SG, Agache IO, Soong W, Israel E, Chupp GL, Cheung DS et al (2021) Astegolimab (anti-ST2) efficacy and safety in adults with severe asthma: a randomized clinical trial. J Allergy Clin Immunol 148(3):790\u2013798. https:\/\/doi.org\/10.1016\/j.jaci.2021.03.044","journal-title":"J Allergy Clin Immunol"},{"key":"9073_CR106","unstructured":"AnaptysBio I (2018) Etokimab in adults with chronic rhinosinusitis with nasal polyps (CRSwNP). ClinicalTrials.gov. Report No.: NCT03614923."},{"issue":"1","key":"9073_CR107","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s13223-024-00894-8","volume":"20","author":"SI Danto","year":"2024","unstructured":"Danto SI, Tsamandouras N, Reddy P, Gilbert SA, Mancuso JY, Page K et al (2024) Exploratory pharmacodynamics and efficacy of PF-06817024 in a phase 1 study of patients with chronic rhinosinusitis and atopic dermatitis. Allergy Asthma Clin Immunol 20(1):46. https:\/\/doi.org\/10.1186\/s13223-024-00894-8","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"6","key":"9073_CR108","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1016\/j.jaci.2007.07.051","volume":"120","author":"SJ Ballantyne","year":"2007","unstructured":"Ballantyne SJ, Barlow JL, Jolin HE, Nath P, Williams AS, Chung KF et al (2007) Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. J Allergy Clin Immunol 120(6):1324\u20131331. https:\/\/doi.org\/10.1016\/j.jaci.2007.07.051","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"9073_CR109","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1159\/000346929","volume":"75","author":"Y Ouyang","year":"2013","unstructured":"Ouyang Y, Fan E, Li Y, Wang X, Zhang L (2013) Clinical characteristics and expression of thymic stromal lymphopoetin in eosinophilic and non-eosinophilic chronic rhinosinusitis. ORL J Otorhinolaryngol Relat Spec 75(1):37\u201345. https:\/\/doi.org\/10.1159\/000346929","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"issue":"9","key":"9073_CR110","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1111\/all.12440","volume":"69","author":"D Miljkovic","year":"2014","unstructured":"Miljkovic D, Bassiouni A, Cooksley C, Ou J, Hauben E, Wormald PJ et al (2014) Association between group 2 innate lymphoid cells enrichment, nasal polyps and allergy in chronic rhinosinusitis. Allergy 69(9):1154\u20131161. https:\/\/doi.org\/10.1111\/all.12440","journal-title":"Allergy"},{"issue":"2","key":"9073_CR111","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1177\/1753425914523460","volume":"21","author":"M Boita","year":"2015","unstructured":"Boita M, Garzaro M, Raimondo L, Riva G, Mazibrada J, Pecorari G et al (2015) Eosinophilic inflammation of chronic rhinosinusitis with nasal polyps is related to OX40 ligand expression. Innate Immun 21(2):167\u2013174. https:\/\/doi.org\/10.1177\/1753425914523460","journal-title":"Innate Immun"},{"issue":"3","key":"9073_CR112","doi-asserted-by":"publisher","first-page":"175","DOI":"10.2500\/ajra.2015.29.4176","volume":"29","author":"M Lam","year":"2015","unstructured":"Lam M, Hull L, Imrie A, Snidvongs K, Chin D, Pratt E et al (2015) Interleukin-25 and interleukin-33 as mediators of eosinophilic inflammation in chronic rhinosinusitis. Am J Rhinol Allergy 29(3):175\u2013181. https:\/\/doi.org\/10.2500\/ajra.2015.29.4176","journal-title":"Am J Rhinol Allergy"},{"issue":"2","key":"9073_CR113","doi-asserted-by":"publisher","first-page":"135","DOI":"10.4193\/Rhino14.078","volume":"53","author":"A Shiozawa","year":"2015","unstructured":"Shiozawa A, Miwa M, Ono N, Homma H, Hirotsu M, Ikeda K (2015) Comparative analysis of cytokine release from epithelial cell cultures of the upper airway. Rhinology 53(2):135\u2013141. https:\/\/doi.org\/10.4193\/Rhino14.078","journal-title":"Rhinology"},{"issue":"4","key":"9073_CR114","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.anai.2017.07.012","volume":"119","author":"F Chen","year":"2017","unstructured":"Chen F, Hong H, Sun Y, Hu X, Zhang J, Xu G et al (2017) Nasal interleukin 25 as a novel biomarker for patients with chronic rhinosinusitis with nasal polyps and airway hypersensitiveness: a pilot study. Ann Allergy Asthma Immunol 119(4):310\u20136.e2. https:\/\/doi.org\/10.1016\/j.anai.2017.07.012","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"11","key":"9073_CR115","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1111\/all.13552","volume":"73","author":"N Ogasawara","year":"2018","unstructured":"Ogasawara N, Klingler AI, Tan BK, Poposki JA, Hulse KE, Stevens WW et al (2018) Epithelial activators of type 2 inflammation: elevation of thymic stromal lymphopoietin, but not IL-25 or IL-33, in chronic rhinosinusitis with nasal polyps in Chicago. Illinois Allergy 73(11):2251\u20132254. https:\/\/doi.org\/10.1111\/all.13552","journal-title":"Illinois Allergy"},{"key":"9073_CR116","doi-asserted-by":"publisher","unstructured":"Wei Y, Ma R, Zhang J, Wu X, Yu G, Hu X et al (2018) Excessive periostin expression and Th2 response in patients with nasal polyps: association with asthma. J Thorac Dis 10(12):6585\u201397. https:\/\/doi.org\/10.21037\/jtd.2018.11.12","DOI":"10.21037\/jtd.2018.11.12"},{"key":"9073_CR117","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s13601-018-0237-4","volume":"20","author":"R Zheng","year":"2018","unstructured":"Zheng R, Wang D, Wang K, Gao WX, Yang QT, Jiang LJ et al (2018) Elevated expression of IL-17RB and ST2 on myeloid dendritic cells is associated with a Th2-skewed eosinophilic inflammation in nasal polyps. Clin Transl Allergy 20:46. https:\/\/doi.org\/10.1186\/s13601-018-0237-4","journal-title":"Clin Transl Allergy"},{"issue":"4","key":"9073_CR118","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1165\/rcmb.2017-0325OC","volume":"59","author":"Y Kato","year":"2018","unstructured":"Kato Y, Takabayashi T, Sakashita M, Imoto Y, Tokunaga T, Ninomiya T et al (2018) Expression and functional analysis of CST1 in intractable nasal polyps. Am J Respir Cell Mol Biol 59(4):448\u2013457. https:\/\/doi.org\/10.1165\/rcmb.2017-0325OC","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"6","key":"9073_CR119","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1007\/s00405-019-05379-8","volume":"276","author":"M Dogan","year":"2019","unstructured":"Dogan M, Sahin M, Yenisey C (2019) Increased TSLP, IL-33, IL-25, IL-19, IL 21 and amphiregulin (AREG) levels in chronic rhinosinusitis with nasal polyp. Eur Arch Otorhinolaryngol 276(6):1685\u20131691. https:\/\/doi.org\/10.1007\/s00405-019-05379-8","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"9073_CR120","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3389\/fimmu.2019.00074","volume":"10","author":"T Yamada","year":"2019","unstructured":"Yamada T, Miyabe Y, Ueki S, Fujieda S, Tokunaga T, Sakashita M et al (2019) Eotaxin-3 as a plasma biomarker for mucosal eosinophil infiltration in chronic rhinosinusitis. Front Immunol 10:74. https:\/\/doi.org\/10.3389\/fimmu.2019.00074","journal-title":"Front Immunol"},{"issue":"2","key":"9073_CR121","doi-asserted-by":"publisher","first-page":"326","DOI":"10.3390\/biom10020326","volume":"10","author":"Y Kobayashi","year":"2020","unstructured":"Kobayashi Y, Kanda A, Yun Y, Van Dan B, Suzuki K, Sawada S et al (2020) Reduced local response to corticosteroids in eosinophilic chronic rhinosinusitis with asthma. Biomolecules 10(2):326. https:\/\/doi.org\/10.3390\/biom10020326","journal-title":"Biomolecules"},{"key":"9073_CR122","doi-asserted-by":"publisher","first-page":"839","DOI":"10.2147\/jaa.S315707","volume":"14","author":"H Deng","year":"2021","unstructured":"Deng H, Li M, Zheng R, Qiu H, Yuan T, Wang W et al (2021) YAP promotes cell proliferation and epithelium-derived cytokine expression via NF-\u03baB pathway in nasal polyps. J Asthma Allergy 14:839\u2013850. https:\/\/doi.org\/10.2147\/jaa.S315707","journal-title":"J Asthma Allergy"},{"issue":"6","key":"9073_CR123","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1002\/alr.23304","volume":"14","author":"MR Chaaban","year":"2024","unstructured":"Chaaban MR, Asosingh K, Comhair S, Hoying D (2024) Assessing the clinico-immunological profile of patients with obesity and chronic rhinosinusitis. Int Forum Allergy Rhinol 14(6):1036\u20131045. https:\/\/doi.org\/10.1002\/alr.23304","journal-title":"Int Forum Allergy Rhinol"},{"issue":"2","key":"9073_CR124","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.immuni.2015.01.016","volume":"42","author":"Y Endo","year":"2015","unstructured":"Endo Y, Hirahara K, Iinuma T, Shinoda K, Tumes DJ, Asou HK et al (2015) The interleukin-33-p38 kinase axis confers memory t helper 2 cell pathogenicity in the airway. Immunity 42(2):294\u2013308. https:\/\/doi.org\/10.1016\/j.immuni.2015.01.016","journal-title":"Immunity"},{"key":"9073_CR125","doi-asserted-by":"publisher","unstructured":"Stevens WW, Ocampo CJ, Berdnikovs S, Sakashita M, Mahdavinia M, Suh L et al (2015) Cytokines in chronic rhinosinusitis. Role in eosinophilia and aspirin-exacerbated respiratory disease. American Journal of Respir Crit Care Med 192(6):682\u201394. https:\/\/doi.org\/10.1164\/rccm.201412-2278OC","DOI":"10.1164\/rccm.201412-2278OC"},{"issue":"9","key":"9073_CR126","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161013","volume":"11","author":"J Xu","year":"2016","unstructured":"Xu J, Han R, Kim DW, Mo J-H, Jin Y, Rha K-S et al (2016) Role of interleukin-10 on nasal polypogenesis in patients with chronic rhinosinusitis with nasal polyps. PLoS ONE 11(9):e0161013. https:\/\/doi.org\/10.1371\/journal.pone.0161013","journal-title":"PLoS ONE"},{"issue":"1","key":"9073_CR127","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s00405-016-4260-6","volume":"274","author":"A Ozturan","year":"2017","unstructured":"Ozturan A, Eyigor H, Eyigor M, Osma U, Yilmaz MD, Selcuk OT et al (2017) The role of IL-25 and IL-33 in chronic rhinosinusitis with or without nasal polyps. Eur Arch Otorhinolaryngol 274(1):283\u2013288. https:\/\/doi.org\/10.1007\/s00405-016-4260-6","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"6","key":"9073_CR128","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1159\/000484527","volume":"79","author":"W Song","year":"2017","unstructured":"Song W, Wang C, Zhou J, Pan S, Lin S (2017) IL-33 expression in chronic rhinosinusitis with nasal polyps and its relationship with clinical severity. ORL J Otorhinolaryngol Relat Spec 79(6):323\u2013330. https:\/\/doi.org\/10.1159\/000484527","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"issue":"4","key":"9073_CR129","doi-asserted-by":"publisher","first-page":"4582","DOI":"10.1002\/jcp.27237","volume":"234","author":"G Chiappara","year":"2018","unstructured":"Chiappara G, Sciarrino S, Di Sano C, Gallina S, Speciale R, Lorusso F et al (2018) Notch-1 signaling activation sustains overexpression of interleukin 33 in the epithelium of nasal polyps. J Cell Physiol 234(4):4582\u20134596. https:\/\/doi.org\/10.1002\/jcp.27237","journal-title":"J Cell Physiol"},{"issue":"1","key":"9073_CR130","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1159\/000503976","volume":"82","author":"X Luo","year":"2020","unstructured":"Luo X, Li C, Wang Y, Yang G, Xu Y, Li G et al (2020) Interleukin-33 promotes Th2\/Th17 response in eosinophilic and non-eosinophilic nasal polyps. ORL J Otorhinolaryngol Relat Spec 82(1):34\u201339. https:\/\/doi.org\/10.1159\/000503976","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"issue":"9","key":"9073_CR131","doi-asserted-by":"publisher","first-page":"3345","DOI":"10.1007\/s00405-020-06600-9","volume":"278","author":"M G\u00fcll\u00fcev","year":"2021","unstructured":"G\u00fcll\u00fcev M, Y\u00fccel A, Kahraman ME, Bor MA (2021) Measurement of some serum cytokines in nasal polyp and evaluation of its correlation with disease severity. Eur Arch Otorhinolaryngol 278(9):3345\u20133349. https:\/\/doi.org\/10.1007\/s00405-020-06600-9","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"5","key":"9073_CR132","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1002\/ohn.904","volume":"171","author":"FR Romano","year":"2024","unstructured":"Romano FR, Valera FCP, Fornazieri MA, Lopes NMD, Miyake MM, Dolci RLL et al (2024) Inflammatory profile of chronic rhinosinusitis with nasal polyp patients in Brazil: multicenter study. Otolaryngol Head Neck Surg 171(5):1552\u20131561. https:\/\/doi.org\/10.1002\/ohn.904","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"9073_CR133","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1002\/alr.23222","volume":"14","author":"SE Yu","year":"2023","unstructured":"Yu SE, Chiang S, Olonisakin TF, Moore JA, Bergmark RW, Maxfield AZ et al (2023) Local cytokine levels associate with SNOT-22 and UPSIT scores in chronic rhinosinusitis. Int Forum Allergy Rhinol 14(1):114\u2013118. https:\/\/doi.org\/10.1002\/alr.23222","journal-title":"Int Forum Allergy Rhinol"},{"key":"9073_CR134","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.2147\/jir.S304320","volume":"14","author":"H Hong","year":"2021","unstructured":"Hong H, Tan KS, Yan Y, Chen F, Ong HH, Oo Y et al (2021) Induction of IL-25 expression in human nasal polyp epithelium by influenza virus infection is abated by interferon-alpha pretreatment. J Inflamm Res 14:2769\u20132780. https:\/\/doi.org\/10.2147\/jir.S304320","journal-title":"J Inflamm Res"}],"container-title":["Clinical Reviews in Allergy &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-025-09073-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12016-025-09073-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-025-09073-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T16:33:01Z","timestamp":1750264381000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12016-025-09073-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,18]]},"references-count":134,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["9073"],"URL":"https:\/\/doi.org\/10.1007\/s12016-025-09073-y","relation":{},"ISSN":["1559-0267"],"issn-type":[{"value":"1559-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,18]]},"assertion":[{"value":"6 June 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article is a review of previously published studies. No new studies involving human participants or animals were conducted by the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"59"}}