{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:31:12Z","timestamp":1787319072728,"version":"build-2736575974"},"reference-count":161,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clinic Rev Allerg Immunol"],"DOI":"10.1007\/s12016-025-09075-w","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T09:04:23Z","timestamp":1752656663000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Atopic Dermatitis beyond Eczema: A Review on its Systemic Impact through Pruritus and Associated Comorbidities"],"prefix":"10.1007","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6799-3727","authenticated-orcid":false,"given":"Alvaro","family":"Prados-Carmona","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-0206","authenticated-orcid":false,"given":"Husein","family":"Husein-ElAhmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5454-3671","authenticated-orcid":false,"given":"Francisco J.","family":"Navarro-Trivi\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0381-6174","authenticated-orcid":false,"given":"Ricardo","family":"Ruiz-Villaverde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"9075_CR1","doi-asserted-by":"publisher","first-page":"S65","DOI":"10.1016\/j.jaci.2017.01.011","volume":"139","author":"PM Brunner","year":"2017","unstructured":"Brunner PM, Guttman-Yassky E, Leung DYM (2017) The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies. J Allergy Clin Immunol 139:S65\u2013S76. https:\/\/doi.org\/10.1016\/j.jaci.2017.01.011","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"9075_CR2","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.jaci.2014.11.015","volume":"135","author":"S Noda","year":"2015","unstructured":"Noda S, Krueger JG, Guttman-Yassky E (2015) The translational revolution and use of biologics in patients with inflammatory skin diseases. J Allergy Clin Immunol 135:324\u2013336. https:\/\/doi.org\/10.1016\/j.jaci.2014.11.015","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"9075_CR3","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.jaad.2018.09.035","volume":"80","author":"YW Yew","year":"2019","unstructured":"Yew YW, Thyssen JP, Silverberg JI (2019) A systematic review and meta-analysis of the regional and age-related differences in atopic dermatitis clinical characteristics. J Am Acad Dermatol 80:390\u2013401. https:\/\/doi.org\/10.1016\/j.jaad.2018.09.035","journal-title":"J Am Acad Dermatol"},{"key":"9075_CR4","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.anai.2018.11.015","volume":"122","author":"PM Brunner","year":"2019","unstructured":"Brunner PM, Guttman-Yassky E (2019) Racial differences in atopic dermatitis. Ann Allergy Asthma Immunol 122:449\u2013455. https:\/\/doi.org\/10.1016\/j.anai.2018.11.015","journal-title":"Ann Allergy Asthma Immunol"},{"key":"9075_CR5","doi-asserted-by":"publisher","first-page":"858","DOI":"10.3390\/jcm4050858","volume":"4","author":"Y Mansouri","year":"2015","unstructured":"Mansouri Y, Guttman-Yassky E (2015) Immune pathways in atopic dermatitis, and definition of biomarkers through broad and targeted therapeutics. J Clin Med 4:858\u2013873. https:\/\/doi.org\/10.3390\/jcm4050858","journal-title":"J Clin Med"},{"key":"9075_CR6","doi-asserted-by":"crossref","unstructured":"Bieber T (2012) Atopic dermatitis 2.0: from the clinical phenotype to the molecular taxonomy and stratified medicine. Allergy: European J Allergy Clin Immunol 67:1475\u20131482","DOI":"10.1111\/all.12049"},{"key":"9075_CR7","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1007\/s12016-021-08880-3","volume":"61","author":"H Li","year":"2021","unstructured":"Li H, Zhang Z, Zhang H et al (2021) Update on the pathogenesis and therapy of atopic dermatitis. Clin Rev Allergy Immunol 61:324\u2013338. https:\/\/doi.org\/10.1007\/s12016-021-08880-3","journal-title":"Clin Rev Allergy Immunol"},{"key":"9075_CR8","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.clindermatol.2017.03.005","volume":"35","author":"ON Kramer","year":"2017","unstructured":"Kramer ON, Strom MA, Ladizinski B, Lio PA (2017) The history of atopic dermatitis. Clin Dermatol 35:344\u2013348. https:\/\/doi.org\/10.1016\/j.clindermatol.2017.03.005","journal-title":"Clin Dermatol"},{"key":"9075_CR9","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.jaci.2022.08.026","volume":"151","author":"GP Geba","year":"2023","unstructured":"Geba GP, Li D, Xu M et al (2023) Attenuating the atopic march: meta-analysis of the dupilumab atopic dermatitis database for incident allergic events. J Allergy\u00a0 Clin Immuno 151:756\u2013766. https:\/\/doi.org\/10.1016\/j.jaci.2022.08.026","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"9075_CR10","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.jaad.2024.05.029","volume":"91","author":"TL Lin","year":"2024","unstructured":"Lin TL, Fan YH, Fan KS et al (2024) Reduced atopic march risk in pediatric atopic dermatitis patients prescribed dupilumab versus conventional immunomodulatory therapy: a population-based cohort study. J Am Acad Dermatol 91:466\u2013473. https:\/\/doi.org\/10.1016\/j.jaad.2024.05.029","journal-title":"J Am Acad Dermatol"},{"key":"9075_CR11","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/s41423-023-00992-4","volume":"20","author":"P Facheris","year":"2023","unstructured":"Facheris P, Jeffery J, Del Duca E, Guttman-Yassky E (2023) The translational revolution in atopic dermatitis: the paradigm shift from pathogenesis to treatment. Cell Mol Immunol 20:448\u2013474. https:\/\/doi.org\/10.1038\/s41423-023-00992-4","journal-title":"Cell Mol Immunol"},{"key":"9075_CR12","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.cyto.2014.11.023","volume":"73","author":"D Malajian","year":"2015","unstructured":"Malajian D, Guttman-Yassky E (2015) New pathogenic and therapeutic paradigms in atopic dermatitis. Cytokine 73:311\u2013318. https:\/\/doi.org\/10.1016\/j.cyto.2014.11.023","journal-title":"Cytokine"},{"key":"9075_CR13","doi-asserted-by":"publisher","DOI":"10.1002\/jvc2.537","author":"A Prados-Carmona","year":"2024","unstructured":"Prados-Carmona A, Navarro-Trivi\u00f1o FJ, Ruiz-Villaverde R, Corell A (2024) Role of interleukins in dermatology: exploring the immune mechanisms in skin diseases. JEADV Clin Prac. https:\/\/doi.org\/10.1002\/jvc2.537","journal-title":"JEADV Clinical Practice"},{"key":"9075_CR14","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.jaci.2014.08.008","volume":"134","author":"DYM Leung","year":"2014","unstructured":"Leung DYM, Guttman-Yassky E (2014) Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches. J Allergy Clin Immunol 134:769\u2013779","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"9075_CR15","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1111\/imr.13326","volume":"323","author":"P Vuscan","year":"2024","unstructured":"Vuscan P, Kischkel B, Joosten LAB, Netea MG (2024) Trained immunity: general and emerging concepts. Immunol Rev 323:164\u2013185","journal-title":"Immunol Rev"},{"key":"9075_CR16","doi-asserted-by":"publisher","unstructured":"Wang R, Lan C, Benlagha K, et al (2024) The interaction of innate immune and adaptive immune system. MedComm (Beijing) 5:. https:\/\/doi.org\/10.1002\/mco2.714","DOI":"10.1002\/mco2.714"},{"key":"9075_CR17","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/cea.14261","volume":"53","author":"L Mart\u00edn-Cruz","year":"2023","unstructured":"Mart\u00edn-Cruz L, Sevilla-Ortega C, Angelina A et al (2023) From trained immunity in allergy to trained immunity-based allergen vaccines. Clin Exp Allergy 53:145\u2013155","journal-title":"Clin Exp Allergy"},{"key":"9075_CR18","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/j.jaci.2024.09.009","volume":"154","author":"L Mart\u00edn-Cruz","year":"2024","unstructured":"Mart\u00edn-Cruz L, Benito-Villalvilla C, Angelina A et al (2024) Trained immunity\u2013based vaccines for infections and allergic diseases. J Allergy Clin Immunol 154:1085\u20131094","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"9075_CR19","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.chom.2018.12.006","volume":"25","author":"MG Netea","year":"2019","unstructured":"Netea MG, Schlitzer A, Placek K et al (2019) Innate and adaptive immune memory: an evolutionary continuum in the host\u2019s response to pathogens. Cell Host Microbe 25:13\u201326. https:\/\/doi.org\/10.1016\/j.chom.2018.12.006","journal-title":"Cell Host Microbe"},{"key":"9075_CR20","doi-asserted-by":"publisher","unstructured":"Hajishengallis G, Chavakis T (2024) Central trained immunity and its impact on chronic inflammatory and autoimmune diseases. J Allergy Clin Immunol. 154(5):1113\u20131116. https:\/\/doi.org\/10.1016\/j.jaci.2024.06.005","DOI":"10.1016\/j.jaci.2024.06.005"},{"key":"9075_CR21","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.1016\/j.jid.2016.07.017","volume":"136","author":"MC Br\u00fcggen","year":"2016","unstructured":"Br\u00fcggen MC, Bauer WM, Reininger B et al (2016) In situ mapping of innate lymphoid cells in human skin: evidence for remarkable differences between normal and inflamed skin. J Investig Dermatol 136:2396\u20132405. https:\/\/doi.org\/10.1016\/j.jid.2016.07.017","journal-title":"J Investig Dermatol"},{"key":"9075_CR22","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1161\/CIRCRESAHA.118.313591","volume":"124","author":"D Wolf","year":"2019","unstructured":"Wolf D, Ley K (2019) Immunity and inflammation in atherosclerosis. Circ Res 124:315\u2013327","journal-title":"Circ Res"},{"key":"9075_CR23","doi-asserted-by":"publisher","first-page":"11324","DOI":"10.3390\/ijms150711324","volume":"15","author":"CM Steyers","year":"2014","unstructured":"Steyers CM, Miller FJ (2014) Endothelial dysfunction in chronic inflammatory diseases. Int J Mol Sci 15:11324\u201311349","journal-title":"Int J Mol Sci"},{"key":"9075_CR24","doi-asserted-by":"publisher","unstructured":"Monteiro R, Azevedo I (2010) Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm 2010:289645.\u00a0 https:\/\/doi.org\/10.1155\/2010\/289645","DOI":"10.1155\/2010\/289645"},{"key":"9075_CR25","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.coph.2016.07.005","volume":"29","author":"R Kolb","year":"2016","unstructured":"Kolb R, Sutterwala FS, Zhang W (2016) Obesity and cancer: inflammation bridges the two. Curr Opin Pharmacol 29:77\u201389","journal-title":"Curr Opin Pharmacol"},{"key":"9075_CR26","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ad.2018.05.009","volume":"110","author":"S Gonz\u00e1lez-Parra","year":"2019","unstructured":"Gonz\u00e1lez-Parra S, Daud\u00e9n E (2019) Psoriasis and depression: the role of inflammation. Actas Dermosifiliogr 110:12\u201319","journal-title":"Actas Dermosifiliogr"},{"key":"9075_CR27","doi-asserted-by":"publisher","unstructured":"Kong P, Cui ZY, Huang XF, Zhang DD, Guo RJ, Han M (2022) Inflammation and atherosclerosis: signaling pathways and therapeutic intervention. Signal Transduct Target Ther 7(1):131. https:\/\/doi.org\/10.1038\/s41392-022-00955-7","DOI":"10.1038\/s41392-022-00955-7"},{"key":"9075_CR28","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1038\/s41573-023-00735-0","volume":"22","author":"T Bieber","year":"2023","unstructured":"Bieber T (2023) Disease modification in inflammatory skin disorders: opportunities and challenges. Nat Rev Drug Discov 22:662\u2013680. https:\/\/doi.org\/10.1038\/s41573-023-00735-0","journal-title":"Nat Rev Drug Discov"},{"key":"9075_CR29","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1017\/S0033291719001454","volume":"49","author":"EF Osimo","year":"2019","unstructured":"Osimo EF, Baxter LJ, Lewis G et al (2019) Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels. Psychol Med 49:1958\u20131970","journal-title":"Psychol Med"},{"key":"9075_CR30","doi-asserted-by":"publisher","unstructured":"Garcovich S, Maurelli M, Gisondi P et al (2021) Pruritus as a distinctive feature of type 2 inflammation. Vaccines (Basel) 9. https:\/\/doi.org\/10.3390\/vaccines9030303","DOI":"10.3390\/vaccines9030303"},{"key":"9075_CR31","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1111\/exd.14014","volume":"28","author":"C Nakashima","year":"2019","unstructured":"Nakashima C, Ishida Y, Kitoh A et al (2019) Interaction of peripheral nerves and mast cells, eosinophils, and basophils in the development of pruritus. Exp Dermatol 28:1405\u20131411. https:\/\/doi.org\/10.1111\/exd.14014","journal-title":"Exp Dermatol"},{"key":"9075_CR32","doi-asserted-by":"publisher","unstructured":"Furue M, Yamamura K, Kido-Nakahara M, et al (2018) Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis. Allergy: European J Allergy Clin Immunol 73:29\u201336. https:\/\/doi.org\/10.1111\/all.13239","DOI":"10.1111\/all.13239"},{"key":"9075_CR33","doi-asserted-by":"publisher","first-page":"T512","DOI":"10.1016\/j.ad.2023.05.013","volume":"114","author":"FJ Navarro-Trivi\u00f1o","year":"2023","unstructured":"Navarro-Trivi\u00f1o FJ (2023) [Translated article] Pruritus in dermatology: part 1\u2014general concepts and pruritogens. Actas Dermosifiliogr 114:T512\u2013T522. https:\/\/doi.org\/10.1016\/j.ad.2023.05.013","journal-title":"Actas Dermosifiliogr"},{"key":"9075_CR34","doi-asserted-by":"publisher","unstructured":"Wong LS, Wu T, Lee CH (2017) Inflammatory and noninflammatory itch: implications in pathophysiolog1y-directed treatments. Int J Mol Sci 18. https:\/\/doi.org\/10.3390\/ijms18071485","DOI":"10.3390\/ijms18071485"},{"key":"9075_CR35","doi-asserted-by":"publisher","first-page":"T613","DOI":"10.1016\/j.ad.2023.06.007","volume":"114","author":"FJ Navarro-Trivi\u00f1o","year":"2023","unstructured":"Navarro-Trivi\u00f1o FJ (2023) [Translated article] Pruritus in dermatology: part 2\u2014diseases and their treatment. Actas Dermosifiliogr 114:T613\u2013T626. https:\/\/doi.org\/10.1016\/j.ad.2023.06.007","journal-title":"Actas Dermosifiliogr"},{"key":"9075_CR36","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s12016-015-8488-5","volume":"51","author":"NK Mollanazar","year":"2016","unstructured":"Mollanazar NK, Smith PK, Yosipovitch G (2016) Mediators of chronic pruritus in atopic dermatitis: getting the itch out? Clin Rev Allergy Immunol 51:263\u2013292. https:\/\/doi.org\/10.1007\/s12016-015-8488-5","journal-title":"Clin Rev Allergy Immunol"},{"key":"9075_CR37","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/exd.13533","volume":"27","author":"C Nakashima","year":"2018","unstructured":"Nakashima C, Otsuka A, Kabashima K (2018) Interleukin-31 and interleukin-31 receptor: new therapeutic targets for atopic dermatitis. Exp Dermatol 27:327\u2013331. https:\/\/doi.org\/10.1111\/exd.13533","journal-title":"Exp Dermatol"},{"key":"9075_CR38","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1056\/nejmoa1606490","volume":"376","author":"T Ruzicka","year":"2017","unstructured":"Ruzicka T, Hanifin JM, Furue M et al (2017) Anti\u2013interleukin-31 receptor a antibody for atopic dermatitis. N Engl J Med 376:826\u2013835. https:\/\/doi.org\/10.1056\/nejmoa1606490","journal-title":"N Engl J Med"},{"key":"9075_CR39","doi-asserted-by":"publisher","unstructured":"Kabashima K, Irie H (2021) Interleukin-31 as a clinical target for pruritus treatment. Front Med (Lausanne) 8. https:\/\/doi.org\/10.3389\/fmed.2021.638325","DOI":"10.3389\/fmed.2021.638325"},{"key":"9075_CR40","doi-asserted-by":"publisher","first-page":"9227","DOI":"10.3390\/ijms24119227","volume":"24","author":"G Murdaca","year":"2023","unstructured":"Murdaca G, Gangemi S, Greco M (2023) The IL-33\/IL-31 axis in allergic and immune-mediated diseases. Int J Mol Sci 24:9227. https:\/\/doi.org\/10.3390\/ijms24119227","journal-title":"Int J Mol Sci"},{"key":"9075_CR41","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1080\/09546634.2017.1290205","volume":"28","author":"MD Saleem","year":"2017","unstructured":"Saleem MD, Oussedik E, D\u2019Amber V, Feldman SR (2017) Interleukin-31 pathway and its role in atopic dermatitis: a systematic review. J Dermatol Treat 28:591\u2013599. https:\/\/doi.org\/10.1080\/09546634.2017.1290205","journal-title":"J Dermatol Treat"},{"key":"9075_CR42","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1007\/s40265-021-01521-1","volume":"81","author":"YS Roh","year":"2021","unstructured":"Roh YS, Choi J, Sutaria N et al (2021) IL-31 inhibition as a therapeutic approach for the management of chronic pruritic dermatoses. Drugs 81:895\u2013905. https:\/\/doi.org\/10.1007\/s40265-021-01521-1","journal-title":"Drugs"},{"key":"9075_CR43","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1080\/1744666X.2021.1940962","volume":"17","author":"C Dubin","year":"2021","unstructured":"Dubin C, Del Duca E, Guttman-Yassky E (2021) The IL-4, IL-13 and IL-31 pathways in atopic dermatitis. Expert Rev Clin Immunol 17:835\u2013852. https:\/\/doi.org\/10.1080\/1744666X.2021.1940962","journal-title":"Expert Rev Clin Immunol"},{"key":"9075_CR44","doi-asserted-by":"publisher","unstructured":"Orfali RL, Aoki V (2023) Blockage of the IL-31 pathway as a potential target therapy for atopic dermatitis. Pharmaceutics 15. https:\/\/doi.org\/10.3390\/pharmaceutics15020577","DOI":"10.3390\/pharmaceutics15020577"},{"key":"9075_CR45","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.jdermsci.2014.02.009","volume":"74","author":"A Kato","year":"2014","unstructured":"Kato A, Fujii E, Watanabe T et al (2014) Distribution of IL-31 and its receptor expressing cells in skin of atopic dermatitis. J Dermatol Sci 74:229\u2013235. https:\/\/doi.org\/10.1016\/j.jdermsci.2014.02.009","journal-title":"J Dermatol Sci"},{"key":"9075_CR46","doi-asserted-by":"publisher","unstructured":"Nemmer JM, Kuchner M, Datsi A et al (2021) Interleukin-31 signaling bridges the gap between immune cells, the nervous system and epithelial tissues. Front Med (Lausanne) 8. https:\/\/doi.org\/10.3389\/fmed.2021.639097","DOI":"10.3389\/fmed.2021.639097"},{"key":"9075_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clim.2015.02.014","volume":"158","author":"F Cedeno-Laurent","year":"2015","unstructured":"Cedeno-Laurent F, Singer EM, Wysocka M et al (2015) Improved pruritus correlates with lower levels of IL-31 in CTCL patients under different therapeutic modalities. Clin Immunol 158:1\u20137. https:\/\/doi.org\/10.1016\/j.clim.2015.02.014","journal-title":"Clin Immunol"},{"key":"9075_CR48","doi-asserted-by":"publisher","first-page":"319","DOI":"10.5114\/ada.2020.96260","volume":"37","author":"B Olszewska","year":"2020","unstructured":"Olszewska B, Wojdylo MS, Lakomy J, Nowicki RJ (2020) The ambiguous pruritogenic role of interleukin-31 in cutaneous T-cell lymphomas in comparison to atopic dermatitis: a review. Postepy Dermatol Alergol 37:319\u2013325. https:\/\/doi.org\/10.5114\/ada.2020.96260","journal-title":"Postepy Dermatol Alergol"},{"key":"9075_CR49","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s12016-025-09057-y","volume":"68","author":"H You","year":"2025","unstructured":"You H, Liang Y (2025) Atopic dermatitis: the relationship between immune mediators and skin lipid barrier. Clin Rev Allergy Immunol 68:49. https:\/\/doi.org\/10.1007\/s12016-025-09057-y","journal-title":"Clin Rev Allergy Immunol"},{"key":"9075_CR50","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1111\/1346-8138.15507","volume":"47","author":"K Furue","year":"2020","unstructured":"Furue K, Ulzii D, Tanaka Y et al (2020) Pathogenic implication of epidermal scratch injury in psoriasis and atopic dermatitis. J Dermatol 47:979\u2013988. https:\/\/doi.org\/10.1111\/1346-8138.15507","journal-title":"J Dermatol"},{"key":"9075_CR51","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/j.jaci.2012.07.012","volume":"130","author":"JK Gittler","year":"2012","unstructured":"Gittler JK, Shemer A, Su\u00e1rez-Fari\u00f1as M et al (2012) Progressive activation of TH2\/TH22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis. Journal of Allergy and Clinical Immunology 130:1344\u20131354. https:\/\/doi.org\/10.1016\/j.jaci.2012.07.012","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"9075_CR52","doi-asserted-by":"publisher","unstructured":"Ulzii D, Kido-Nakahara M, Nakahara T et al (2019) Scratching counteracts il-13 signaling by upregulating the decoy receptor il-13r\u03b12 in keratinocytes. Int J Mol Sci 20. https:\/\/doi.org\/10.3390\/ijms20133324","DOI":"10.3390\/ijms20133324"},{"key":"9075_CR53","doi-asserted-by":"publisher","unstructured":"Lee HJ, Hong YJ, Kim M (2021) Angiogenesis in chronic inflammatory skin disorders. Int J Mol Sci 22. https:\/\/doi.org\/10.3390\/ijms222112035","DOI":"10.3390\/ijms222112035"},{"key":"9075_CR54","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.25987","volume":"7","author":"L Psychogiou","year":"2024","unstructured":"Psychogiou L, Navarro MC, Orri M et al (2024) Childhood and adolescent depression symptoms and young adult mental health and psychosocial outcomes. JAMA Netw Open 7:e2425987. https:\/\/doi.org\/10.1001\/jamanetworkopen.2024.25987","journal-title":"JAMA Netw Open"},{"key":"9075_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1525-1470.2008.00813.x","volume":"26","author":"G Ricci","year":"2009","unstructured":"Ricci G, Bendandi B, Aiazzi R et al (2009) Three years of Italian experience of an educational program for parents of young children affected by atopic dermatitis: improving knowledge produces lower anxiety levels in parents of children with atopic dermatitis. Pediatr Dermatol 26:1\u20135. https:\/\/doi.org\/10.1111\/j.1525-1470.2008.00813.x","journal-title":"Pediatr Dermatol"},{"key":"9075_CR56","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/j.1525-1470.2006.00277.x","volume":"23","author":"M Grillo","year":"2006","unstructured":"Grillo M, Gassner L, Marshman G et al (2006) Pediatric atopic eczema: the impact of an educational intervention. Pediatr Dermatol 23:428\u2013436. https:\/\/doi.org\/10.1111\/j.1525-1470.2006.00277.x","journal-title":"Pediatr Dermatol"},{"key":"9075_CR57","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.anr.2015.06.002","volume":"9","author":"Y Lee","year":"2015","unstructured":"Lee Y, Oh J (2015) Educational programs for the management of childhood atopic dermatitis: an integrative review. Asian Nurs Res (Korean Soc Nurs Sci) 9:185\u2013193. https:\/\/doi.org\/10.1016\/j.anr.2015.06.002","journal-title":"Asian Nurs Res (Korean Soc Nurs Sci)"},{"key":"9075_CR58","doi-asserted-by":"publisher","unstructured":"Sy W, Lamb AJ (2017) Atopic Dermatitis Disease Education. Adv Exp Med Biol. 1027:179\u2013184.https:\/\/doi.org\/10.1007\/978-3-319-64804-0_14","DOI":"10.1007\/978-3-319-64804-0_14"},{"key":"9075_CR59","doi-asserted-by":"publisher","first-page":"694","DOI":"10.3349\/ymj.2019.60.7.694","volume":"60","author":"MK Lee","year":"2019","unstructured":"Lee MK, Seo J-H, Chu H et al (2019) Current status of patient education in the management of atopic dermatitis in Korea. Yonsei Med J 60:694. https:\/\/doi.org\/10.3349\/ymj.2019.60.7.694","journal-title":"Yonsei Med J"},{"key":"9075_CR60","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/pai.12358","volume":"26","author":"B Ahrens","year":"2015","unstructured":"Ahrens B, Staab D (2015) Extended implementation of educational programs for atopic dermatitis in childhood. Pediatr Allergy Immunol 26:190\u2013196. https:\/\/doi.org\/10.1111\/pai.12358","journal-title":"Pediatr Allergy Immunol"},{"key":"9075_CR61","doi-asserted-by":"publisher","unstructured":"Schut C, Mahmutovic V, Gieler U, Kupfer J (2012) Patient education programs for childhood atopic dermatitis: who is interested? JDDG: Journal der Deutschen Dermatologischen Gesellschaft 10:657\u2013661. https:\/\/doi.org\/10.1111\/j.1610-0387.2012.07920.x","DOI":"10.1111\/j.1610-0387.2012.07920.x"},{"key":"9075_CR62","doi-asserted-by":"publisher","first-page":"884","DOI":"10.3390\/jcm4050884","volume":"4","author":"EC Siegfried","year":"2015","unstructured":"Siegfried EC, Hebert AA (2015) Diagnosis of atopic dermatitis: mimics, overlaps, and complications. J Clin Med 4:884\u2013917","journal-title":"J Clin Med"},{"key":"9075_CR63","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/j.jaci.2009.10.009","volume":"124","author":"JA Odhiambo","year":"2009","unstructured":"Odhiambo JA, Williams HC, Clayton TO et al (2009) Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three. J Allergy Clin Immunol 124:1251\u20138.e23. https:\/\/doi.org\/10.1016\/j.jaci.2009.10.009","journal-title":"J Allergy Clin Immunol"},{"key":"9075_CR64","doi-asserted-by":"publisher","unstructured":"Marenholz I, Esparza-Gordillo J, R\u00fcschendorf F et al (2015) Meta-analysis identifies seven susceptibility loci involved in the atopic March. Nat Commun 6. https:\/\/doi.org\/10.1038\/ncomms9804","DOI":"10.1038\/ncomms9804"},{"key":"9075_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1365-2249.2005.02980.x","volume":"144","author":"BS Baker","year":"2006","unstructured":"Baker BS (2006) The role of microorganisms in atopic dermatitis. Clin Exp Immunol 144:1\u20139","journal-title":"Clin Exp Immunol"},{"key":"9075_CR66","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1016\/j.jaci.2011.01.053","volume":"127","author":"E Guttman-Yassky","year":"2011","unstructured":"Guttman-Yassky E, Nograles KE, Krueger JG (2011) Contrasting pathogenesis of atopic dermatitis and psoriasis - part i: clinical and pathologic concepts. J Allergy\u00a0 Clin Immunol 127:1110\u20131118. https:\/\/doi.org\/10.1016\/j.jaci.2011.01.053","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"9075_CR67","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1056\/NEJMra1011040","volume":"365","author":"AD Irvine","year":"2011","unstructured":"Irvine AD, McLean WHI, Leung DYM (2011) Filaggrin mutations associated with skin and allergic diseases. N Engl J Med 365:1315\u20131327. https:\/\/doi.org\/10.1056\/NEJMra1011040","journal-title":"N Engl J Med"},{"key":"9075_CR68","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1038\/jid.2009.71","volume":"129","author":"T Werfel","year":"2009","unstructured":"Werfel T (2009) The role of leukocytes, keratinocytes, and allergen-specific IgE in the development of atopic dermatitis. J Investig Dermatol 129:1878\u20131891. https:\/\/doi.org\/10.1038\/jid.2009.71","journal-title":"J Investig Dermatol"},{"key":"9075_CR69","doi-asserted-by":"publisher","unstructured":"Belgrave DCM, Granell R, Simpson A et al (2014) Developmental profiles of eczema, wheeze, and rhinitis: two population-based birth cohort studies. PLoS Med 11. https:\/\/doi.org\/10.1371\/journal.pmed.1001748","DOI":"10.1371\/journal.pmed.1001748"},{"key":"9075_CR70","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.jaci.2022.12.824","volume":"151","author":"T Bieber","year":"2023","unstructured":"Bieber T (2023) In search of the Holy Grail in atopic dermatitis: will dupilumab become the first disease-modifying atopic dermatitis drug? J Allergy Clin Immunol 151:694\u2013696. https:\/\/doi.org\/10.1016\/j.jaci.2022.12.824","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"9075_CR71","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.jaad.2021.11.014","volume":"86","author":"YS Roh","year":"2022","unstructured":"Roh YS, Huang AH, Sutaria N et al (2022) Real-world comorbidities of atopic dermatitis in the US adult ambulatory population. J Am Acad Dermatol 86:835\u2013845. https:\/\/doi.org\/10.1016\/j.jaad.2021.11.014","journal-title":"J Am Acad Dermatol"},{"key":"9075_CR72","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.07.023","author":"A Kabil","year":"2024","unstructured":"Kabil A, Nayyar N, Brassard J et al (2024) Microbial intestinal dysbiosis drives long-term allergic susceptibility by sculpting an ILC2\u2013B1 cell\u2013innate IgE axis. J Allergy Clin Immunol. https:\/\/doi.org\/10.1016\/j.jaci.2024.07.023","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"9075_CR73","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/bjd.15628","volume":"177","author":"AB Simonsen","year":"2017","unstructured":"Simonsen AB, Johansen JD, Deleuran M et al (2017) Contact allergy in children with atopic dermatitis: a systematic review. Br J Dermatol 177:395\u2013405. https:\/\/doi.org\/10.1111\/bjd.15628","journal-title":"Br J Dermatol"},{"key":"9075_CR74","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jaad.2017.02.001","volume":"77","author":"CR Hamann","year":"2017","unstructured":"Hamann CR, Hamann D, Egeberg A et al (2017) Association between atopic dermatitis and contact sensitization: a systematic review and meta-analysis. J Am Acad Dermatol 77:70\u201378. https:\/\/doi.org\/10.1016\/j.jaad.2017.02.001","journal-title":"J Am Acad Dermatol"},{"key":"9075_CR75","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.jaad.2023.06.048","volume":"89","author":"H Johnson","year":"2023","unstructured":"Johnson H, Aquino MR, Snyder A et al (2023) Prevalence of allergic contact dermatitis in children with and without atopic dermatitis: a multicenter retrospective case-control study. J Am Acad Dermatol 89:1007\u20131014. https:\/\/doi.org\/10.1016\/j.jaad.2023.06.048","journal-title":"J Am Acad Dermatol"},{"key":"9075_CR76","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1111\/jdv.14973","volume":"32","author":"M Boonstra","year":"2018","unstructured":"Boonstra M, Rustemeyer T, Middelkamp-Hup MA (2018) Both children and adult patients with difficult-to-treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized. J Eur Acad Dermatol Venereol 32:1554\u20131561. https:\/\/doi.org\/10.1111\/jdv.14973","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"9075_CR77","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/cod.14130","volume":"87","author":"D Bonamonte","year":"2022","unstructured":"Bonamonte D, Hansel K, Romita P et al (2022) Contact allergy in children with and without atopic dermatitis: an Italian multicentre study. Contact Dermatitis 87:265\u2013272. https:\/\/doi.org\/10.1111\/cod.14130","journal-title":"Contact Dermatitis"},{"key":"9075_CR78","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1111\/cod.14494","volume":"90","author":"K Trimeche","year":"2024","unstructured":"Trimeche K, Lahouel I, Belhadjali H et al (2024) Contact allergy in atopic dermatitis: a prospective study on prevalence, incriminated allergens and clinical insights. Contact Dermatitis 90:514\u2013519. https:\/\/doi.org\/10.1111\/cod.14494","journal-title":"Contact Dermatitis"},{"key":"9075_CR79","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.jaad.2018.07.017","volume":"79","author":"S Rastogi","year":"2018","unstructured":"Rastogi S, Patel KR, Singam V, Silverberg JI (2018) Allergic contact dermatitis to personal care products and topical medications in adults with atopic dermatitis. J Am Acad Dermatol 79:1028-1033.e6. https:\/\/doi.org\/10.1016\/j.jaad.2018.07.017","journal-title":"J Am Acad Dermatol"},{"key":"9075_CR80","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/jdv.14737","volume":"32","author":"AB Simonsen","year":"2018","unstructured":"Simonsen AB, Johansen JD, Deleuran M et al (2018) Children with atopic dermatitis may have unacknowledged contact allergies contributing to their skin symptoms. J Eur Acad Dermatol Venereol 32:428\u2013436. https:\/\/doi.org\/10.1111\/jdv.14737","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"9075_CR81","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.jaci.2012.06.048","volume":"131","author":"JK Gittler","year":"2013","unstructured":"Gittler JK, Krueger JG, Guttman-Yassky E (2013) Atopic dermatitis results in intrinsic barrier and immune abnormalities: implications for contact dermatitis. Journal of Allergy and Clinical Immunology 131:300\u2013313. https:\/\/doi.org\/10.1016\/j.jaci.2012.06.048","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"9075_CR82","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s40257-017-0340-7","volume":"19","author":"JL Owen","year":"2018","unstructured":"Owen JL, Vakharia PP, Silverberg JI (2018) The role and diagnosis of allergic contact dermatitis in patients with atopic dermatitis. Am J Clin Dermatol 19:293\u2013302. https:\/\/doi.org\/10.1007\/s40257-017-0340-7","journal-title":"Am J Clin Dermatol"},{"key":"9075_CR83","doi-asserted-by":"publisher","unstructured":"Sidbury R, Tom WL, Bergman JN et al (2014) Guidelines of care for the management of atopic dermatitis: section 4. J Am Acad Dermatol 71:1218\u20131233. https:\/\/doi.org\/10.1016\/j.jaad.2014.08.038","DOI":"10.1016\/j.jaad.2014.08.038"},{"key":"9075_CR84","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1007\/s12016-018-8711-2","volume":"56","author":"J Borok","year":"2019","unstructured":"Borok J, Matiz C, Goldenberg A, Jacob SE (2019) Contact dermatitis in atopic dermatitis children\u2014past, present, and future. Clin Rev Allergy Immunol 56:86\u201398. https:\/\/doi.org\/10.1007\/s12016-018-8711-2>","journal-title":"Clin Rev Allergy Immunol"},{"key":"9075_CR85","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s12016-019-08733-0","volume":"57","author":"P Capucilli","year":"2019","unstructured":"Capucilli P, Hill DA (2019) Allergic comorbidity in eosinophilic esophagitis: mechanistic relevance and clinical implications. Clin Rev Allergy Immunol 57:111\u2013127. https:\/\/doi.org\/10.1007\/s12016-019-08733-0","journal-title":"Clin Rev Allergy Immunol"},{"key":"9075_CR86","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1016\/j.jaip.2018.05.010","volume":"6","author":"DA Hill","year":"2018","unstructured":"Hill DA, Grundmeier RW, Ramos M, Spergel JM (2018) Eosinophilic esophagitis is a late manifestation of the allergic march. J Allergy Clin Immunol Pract 6:1528\u20131533. https:\/\/doi.org\/10.1016\/j.jaip.2018.05.010","journal-title":"J Allergy Clin Immunol Pract"},{"key":"9075_CR87","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1016\/j.jaad.2022.01.009","volume":"86","author":"DMR Davis","year":"2022","unstructured":"Davis DMR, Drucker AM, Alikhan A et al (2022) American Academy of Dermatology guidelines: awareness of comorbidities associated with atopic dermatitis in adults. J Am Acad Dermatol 86(6):1335\u20131336.e18. https:\/\/doi.org\/10.1016\/j.jaad.2022.01.009","journal-title":"J Am Acad Dermatol"},{"key":"9075_CR88","doi-asserted-by":"crossref","unstructured":"Sweeney A, Sampath V, Nadeau KC (2021) Early intervention of atopic dermatitis as a preventive strategy for progression of food allergy. Allergy, Asthma Clin Immunol 17","DOI":"10.1186\/s13223-021-00531-8"},{"key":"9075_CR89","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.jaad.2022.12.029","volume":"89","author":"R Sidbury","year":"2023","unstructured":"Sidbury R, Alikhan A, Bercovitch L et al (2023) Guidelines of care for the management of atopic dermatitis in adults with topical therapies. J Am Acad Dermatol 89:e1\u2013e20. https:\/\/doi.org\/10.1016\/j.jaad.2022.12.029","journal-title":"J Am Acad Dermatol"},{"key":"9075_CR90","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jaci.2018.11.006","volume":"143","author":"AS Paller","year":"2019","unstructured":"Paller AS, Spergel JM, Mina-Osorio P, Irvine AD (2019) The atopic march and atopic multimorbidity: many trajectories, many pathways. J Allergy Clin Immunol 143:46\u201355. https:\/\/doi.org\/10.1016\/j.jaci.2018.11.006","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"9075_CR91","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41573-021-00266-6","volume":"21","author":"T Bieber","year":"2022","unstructured":"Bieber T (2022) Atopic dermatitis: an expanding therapeutic pipeline for a complex disease. Nat Rev Drug Discov 21:21\u201340. https:\/\/doi.org\/10.1038\/s41573-021-00266-6","journal-title":"Nat Rev Drug Discov"},{"key":"9075_CR92","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/j.jaci.2022.12.002","volume":"151","author":"JP Thyssen","year":"2023","unstructured":"Thyssen JP, Halling A-S, Schmid-Grendelmeier P et al (2023) Comorbidities of atopic dermatitis\u2014what does the evidence say? J Allergy Clin Immunol 151:1155\u20131162. https:\/\/doi.org\/10.1016\/j.jaci.2022.12.002","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"9075_CR93","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.jaci.2022.03.030","volume":"150","author":"S de Lusignan","year":"2022","unstructured":"de Lusignan S, Alexander H, Broderick C et al (2022) Atopic dermatitis and risk of autoimmune conditions: population-based cohort study. J Allergy Clin Immunol 150:709\u2013713. https:\/\/doi.org\/10.1016\/j.jaci.2022.03.030","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"9075_CR94","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s40257-019-00474-2","volume":"21","author":"G Shalom","year":"2020","unstructured":"Shalom G, Kridin K, Raviv K-O et al (2020) Atopic dermatitis and celiac disease: a cross-sectional study of 116,816 patients. Am J Clin Dermatol 21:133\u2013138. https:\/\/doi.org\/10.1007\/s40257-019-00474-2","journal-title":"Am J Clin Dermatol"},{"key":"9075_CR95","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.jid.2020.05.091","volume":"141","author":"S Kauppi","year":"2021","unstructured":"Kauppi S, Jokelainen J, Timonen M et al (2021) Atopic dermatitis is associated with dermatitis herpetiformis and celiac disease in children. J Investig Dermatol 141:191-193.e2. https:\/\/doi.org\/10.1016\/j.jid.2020.05.091","journal-title":"J Investig Dermatol"},{"key":"9075_CR96","doi-asserted-by":"publisher","unstructured":"Prados\u2010Carmona A, Ruiz\u2010Villaverde R, Navarro\u2010Trivi\u00f1o FJ (2024) Could baricitinib be a safe and effective therapeutic alternative for incoercible pruritus in patients with dermatitis herpetiformis? Int J Dermatol 63. https:\/\/doi.org\/10.1111\/ijd.16878","DOI":"10.1111\/ijd.16878"},{"key":"9075_CR97","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1111\/j.1365-2133.2012.11002.x","volume":"167","author":"K Ezzedine","year":"2012","unstructured":"Ezzedine K, Diallo A, L\u00e9aut\u00e9-Labr\u00e8ze C et al (2012) Pre- vs. post-pubertal onset of vitiligo: multivariate analysis indicates atopic diathesis association in pre-pubertal onset vitiligo. Br J Dermatol 167:490\u2013495. https:\/\/doi.org\/10.1111\/j.1365-2133.2012.11002.x","journal-title":"Br J Dermatol"},{"key":"9075_CR98","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1001\/jamadermatol.2014.3324","volume":"151","author":"GC Mohan","year":"2015","unstructured":"Mohan GC, Silverberg JI (2015) Association of vitiligo and alopecia areata with atopic dermatitis. JAMA Dermatol 151:522. https:\/\/doi.org\/10.1001\/jamadermatol.2014.3324","journal-title":"JAMA Dermatol"},{"key":"9075_CR99","doi-asserted-by":"publisher","unstructured":"Zhou W, Cai J, Li Z, Lin Y (2023) Association of atopic dermatitis with autoimmune diseases: a bidirectional and multivariable two-sample mendelian randomization study. Front Immunol 14.\u00a0https:\/\/doi.org\/10.3389\/fimmu.2023.1132719","DOI":"10.3389\/fimmu.2023.1132719"},{"key":"9075_CR100","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/j.jaip.2020.01.052","volume":"8","author":"K Kridin","year":"2020","unstructured":"Kridin K, Renert-Yuval Y, Guttman-Yassky E, Cohen AD (2020) Alopecia areata is associated with atopic diathesis: results from a population-based study of 51,561 patients. J Allergy Clin Immunol Pract 8:1323-1328.e1. https:\/\/doi.org\/10.1016\/j.jaip.2020.01.052","journal-title":"J Allergy Clin Immunol Pract"},{"key":"9075_CR101","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1111\/cea.13729","volume":"50","author":"Y Wei","year":"2020","unstructured":"Wei Y, Tai Y, Dai Y et al (2020) Bidirectional association between alopecia areata and atopic dermatitis: a population-based cohort study in Taiwan. Clin Exp Allergy 50:1406\u20131414. https:\/\/doi.org\/10.1111\/cea.13729","journal-title":"Clin Exp Allergy"},{"key":"9075_CR102","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1111\/bjd.19624","volume":"185","author":"LU Ivert","year":"2021","unstructured":"Ivert LU, Wahlgren C-F, Lindel\u00f6f B et al (2021) Association between atopic dermatitis and autoimmune diseases: a population-based case\u2013control study*. Br J Dermatol 185:335\u2013342. https:\/\/doi.org\/10.1111\/bjd.19624","journal-title":"Br J Dermatol"},{"key":"9075_CR103","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.jaci.2019.09.015","volume":"145","author":"KE Lowe","year":"2020","unstructured":"Lowe KE, Mansfield KE, Delmestri A et al (2020) Atopic eczema and fracture risk in adults: a population-based cohort study. J Allergy Clin Immunol 145:563-571.e8. https:\/\/doi.org\/10.1016\/j.jaci.2019.09.015","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"9075_CR104","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1111\/jdv.16895","volume":"35","author":"IM Mukovozov","year":"2021","unstructured":"Mukovozov IM, Morra DE, Giustini D et al (2021) Atopic dermatitis and bone health: a systematic review. J Eur Acad Dermatol Venereol 35:615\u2013628","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"9075_CR105","doi-asserted-by":"publisher","unstructured":"Kim S, Choi J, Cho MK et al (2021) Bone mineral density and osteoporosis risk in young adults with atopic dermatitis. Sci Rep 11. https:\/\/doi.org\/10.1038\/s41598-021-03630-z","DOI":"10.1038\/s41598-021-03630-z"},{"key":"9075_CR106","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.jaci.2019.10.029","volume":"145","author":"PD Arkwright","year":"2020","unstructured":"Arkwright PD, Mughal MZ (2020) Vertebral, pelvic, and hip fracture risk in adults with severe atopic dermatitis. J Allergy Clin Immunol 145:487\u2013488","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"9075_CR107","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.jaad.2013.10.036","volume":"70","author":"JJ Chen","year":"2014","unstructured":"Chen JJ, Applebaum DS, Sun GS, Pflugfelder SC (2014) Atopic keratoconjunctivitis: a review. J Am Acad Dermatol 70:569\u2013575. https:\/\/doi.org\/10.1016\/j.jaad.2013.10.036","journal-title":"J Am Acad Dermatol"},{"key":"9075_CR108","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.jaad.2020.11.037","volume":"85","author":"NH Ravn","year":"2021","unstructured":"Ravn NH, Ahmadzay ZF, Christensen TA et al (2021) Bidirectional association between atopic dermatitis, conjunctivitis, and other ocular surface diseases: a systematic review and meta-analysis. J Am Acad Dermatol 85:453\u2013461. https:\/\/doi.org\/10.1016\/j.jaad.2020.11.037","journal-title":"J Am Acad Dermatol"},{"key":"9075_CR109","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jaad.2017.03.003","volume":"77","author":"JP Thyssen","year":"2017","unstructured":"Thyssen JP, Toft PB, Halling-Overgaard A-S et al (2017) Incidence, prevalence, and risk of selected ocular disease in adults with atopic dermatitis. J Am Acad Dermatol 77:280-286.e1. https:\/\/doi.org\/10.1016\/j.jaad.2017.03.003","journal-title":"J Am Acad Dermatol"},{"key":"9075_CR110","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1097\/ACI.0000000000000935","volume":"23","author":"N Erdinest","year":"2023","unstructured":"Erdinest N, Wajnsztajn D, London N, Solomon A (2023) Ocular surface inflammation and ectatic corneal disorders. Curr Opin Allergy Clin Immunol 23:430\u2013437. https:\/\/doi.org\/10.1097\/ACI.0000000000000935","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"9075_CR111","doi-asserted-by":"publisher","first-page":"21258","DOI":"10.1038\/s41598-022-25589-1","volume":"12","author":"J-S Paik","year":"2022","unstructured":"Paik J-S, Han K, Nam G et al (2022) Increased risk of cataract surgery in patients with allergic disease: a population based cohort study. Sci Rep 12:21258. https:\/\/doi.org\/10.1038\/s41598-022-25589-1","journal-title":"Sci Rep"},{"key":"9075_CR112","doi-asserted-by":"publisher","first-page":"10694","DOI":"10.1038\/s41598-024-57619-5","volume":"14","author":"K Han","year":"2024","unstructured":"Han K, Jung J-H, Jung Y et al (2024) The risk of open angle glaucoma in young adults with allergic diseases: a nationwide cohort study. Sci Rep 14:10694. https:\/\/doi.org\/10.1038\/s41598-024-57619-5","journal-title":"Sci Rep"},{"key":"9075_CR113","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1080\/09286586.2023.2276193","volume":"31","author":"S Kim","year":"2024","unstructured":"Kim S, Kim BH, Han K et al (2024) Association between three atopic triad and retinal vein occlusion risk: a nationwide population-based study. Ophthalmic Epidemiol 31:301\u2013310. https:\/\/doi.org\/10.1080\/09286586.2023.2276193","journal-title":"Ophthalmic Epidemiol"},{"key":"9075_CR114","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1097\/OPX.0000000000001244","volume":"95","author":"L Tan","year":"2018","unstructured":"Tan L, Teo L, Lee SY (2018) Case series: bilateral rhegmatogenous retinal detachments in atopic dermatitis. Optom Vis Sci 95:621\u2013624. https:\/\/doi.org\/10.1097\/OPX.0000000000001244","journal-title":"Optom Vis Sci"},{"key":"9075_CR115","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1038\/eye.2017.151","volume":"31","author":"V Gnana Jothi","year":"2017","unstructured":"Gnana Jothi V, McGimpsey S, Sharkey JA, Chan WC (2017) Retinal detachment repair and cataract surgery in patients with atopic dermatitis. Eye 31:1296\u20131301. https:\/\/doi.org\/10.1038\/eye.2017.151","journal-title":"Eye"},{"key":"9075_CR116","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.anai.2020.08.002","volume":"126","author":"V Wang","year":"2021","unstructured":"Wang V, Boguniewicz J, Boguniewicz M, Ong PY (2021) The infectious complications of atopic dermatitis. Ann Allergy Asthma Immunol 126:3\u201312. https:\/\/doi.org\/10.1016\/j.anai.2020.08.002","journal-title":"Ann Allergy Asthma Immunol"},{"key":"9075_CR117","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1007\/s40257-024-00856-1","volume":"25","author":"R Salle","year":"2024","unstructured":"Salle R, Del Giudice P, Skayem C et al (2024) Secondary bacterial infections in patients with atopic dermatitis or other common dermatoses. Am J Clin Dermatol 25:623\u2013637. https:\/\/doi.org\/10.1007\/s40257-024-00856-1","journal-title":"Am J Clin Dermatol"},{"key":"9075_CR118","doi-asserted-by":"publisher","unstructured":"See\u00a0Tow HX, Yew YW (2024) Malassezia specific IgE in head and neck dermatitis of eczema: a systematic review & meta\u2010analysis. Exp Dermatol 33.\u00a0https:\/\/doi.org\/10.1111\/exd.15108","DOI":"10.1111\/exd.15108"},{"key":"9075_CR119","doi-asserted-by":"publisher","unstructured":"Chu H, Kim SM, Zhang K et al (2023) Head and neck dermatitis is exacerbated by Malassezia furfur colonization, skin barrier disruption, and immune dysregulation. Front Immunol 14. https:\/\/doi.org\/10.3389\/fimmu.2023.1114321","DOI":"10.3389\/fimmu.2023.1114321"},{"key":"9075_CR120","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s12016-024-09000-7","volume":"66","author":"AC Chong","year":"2024","unstructured":"Chong AC, Navarro-Trivi\u00f1o FJ, Su M, Park CO (2024) Fungal head and neck dermatitis: current understanding and management. Clin Rev Allergy Immunol 66:363\u2013375. https:\/\/doi.org\/10.1007\/s12016-024-09000-7","journal-title":"Clin Rev Allergy Immunol"},{"key":"9075_CR121","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1056\/NEJMra2023911","volume":"384","author":"S St\u00e4nder","year":"2021","unstructured":"St\u00e4nder S (2021) Atopic dermatitis. N Engl J Med 384:1136\u20131143. https:\/\/doi.org\/10.1056\/NEJMra2023911","journal-title":"N Engl J Med"},{"key":"9075_CR122","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s40257-025-00917-z","volume":"26","author":"M Napolitano","year":"2025","unstructured":"Napolitano M, Esposito M, Fargnoli MC et al (2025) Infections in patients with atopic dermatitis and the influence of treatment. Am J Clin Dermatol 26:183\u2013197. https:\/\/doi.org\/10.1007\/s40257-025-00917-z","journal-title":"Am J Clin Dermatol"},{"key":"9075_CR123","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jaad.2017.09.052","volume":"78","author":"P Fleming","year":"2018","unstructured":"Fleming P, Drucker AM (2018) Risk of infection in patients with atopic dermatitis treated with dupilumab: a meta-analysis of randomized controlled trials. J Am Acad Dermatol 78(1):62\u201369.e1. https:\/\/doi.org\/10.1016\/j.jaad.2017.09.052","journal-title":"J Am Acad Dermatol"},{"key":"9075_CR124","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20724","author":"K Kridin","year":"2025","unstructured":"Kridin K, Abdelghaffar M, Bieber K et al (2025) The real-world, long-term risk of infections associated with dupilumab in atopic dermatitis: a global cohort study. J Eur Acad Dermatol Venereol. https:\/\/doi.org\/10.1111\/jdv.20724","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"9075_CR125","doi-asserted-by":"publisher","unstructured":"Kim JH, Lee E, Ha EK et al (2024) Cascade of atopic dermatitis comorbidities in children after birth for 15 years. Allergy: European J Allergy Clin Immunol 79:153\u2013163. https:\/\/doi.org\/10.1111\/all.15917","DOI":"10.1111\/all.15917"},{"key":"9075_CR126","doi-asserted-by":"crossref","unstructured":"Xie C, Yang J, Gul A et al (2024) Immunologic aspects of asthma: from molecular mechanisms to disease pathophysiology and clinical translation. Front Immunol 15","DOI":"10.3389\/fimmu.2024.1478624"},{"key":"9075_CR127","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s12016-022-08956-8","volume":"63","author":"F Gibson","year":"2022","unstructured":"Gibson F, Hanly A, Grbic N et al (2022) Epigenetic dysregulation in autoimmune and inflammatory skin diseases. Clin Rev Allergy Immunol 63:447\u2013471. https:\/\/doi.org\/10.1007\/s12016-022-08956-8","journal-title":"Clin Rev Allergy Immunol"},{"key":"9075_CR128","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1016\/j.amjmed.2015.05.041","volume":"128","author":"KF Hjuler","year":"2015","unstructured":"Hjuler KF, B\u00f6ttcher M, Vestergaard C et al (2015) Increased prevalence of coronary artery disease in severe psoriasis and severe atopic dermatitis. Am J Med 128:1325-1334.e2. https:\/\/doi.org\/10.1016\/j.amjmed.2015.05.041","journal-title":"Am J Med"},{"key":"9075_CR129","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.jpeds.2016.03.063","volume":"174","author":"MA Strom","year":"2016","unstructured":"Strom MA, Silverberg JI (2016) Associations of physical activity and sedentary behavior with atopic disease in United States children. J Pediatr 174:247-253.e3. https:\/\/doi.org\/10.1016\/j.jpeds.2016.03.063","journal-title":"J Pediatr"},{"key":"9075_CR130","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1001\/jamadermatol.2014.3059","volume":"151","author":"JI Silverberg","year":"2015","unstructured":"Silverberg JI, Becker L, Kwasny M et al (2015) Central obesity and high blood pressure in pediatric patients with atopic dermatitis. JAMA Dermatol 151:144\u2013152. https:\/\/doi.org\/10.1001\/jamadermatol.2014.3059","journal-title":"JAMA Dermatol"},{"key":"9075_CR131","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.jaad.2014.12.013","volume":"72","author":"A Zhang","year":"2015","unstructured":"Zhang A, Silverberg JI (2015) Association of atopic dermatitis with being overweight and obese: a systematic review and metaanalysis. J Am Acad Dermatol 72:606-616.e4. https:\/\/doi.org\/10.1016\/j.jaad.2014.12.013","journal-title":"J Am Acad Dermatol"},{"key":"9075_CR132","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.jaci.2014.11.023","volume":"135","author":"JI Silverberg","year":"2015","unstructured":"Silverberg JI, Greenland P (2015) Eczema and cardiovascular risk factors in 2 US adult population studies. J Allergy Clin Immunol 135:721-728.e6. https:\/\/doi.org\/10.1016\/j.jaci.2014.11.023","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"9075_CR133","doi-asserted-by":"publisher","unstructured":"Silverberg JI (2015) Association between adult atopic dermatitis, cardiovascular disease, and increased heart attacks in three population-based studies. Allergy. 70(10):1300\u20138. https:\/\/doi.org\/10.1111\/all.12685\u00a0","DOI":"10.1111\/all.12685"},{"key":"9075_CR134","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1097\/DER.0000000000000047","volume":"25","author":"JI Silverberg","year":"2014","unstructured":"Silverberg JI, Simpson EL (2014) Association between obesity and eczema prevalence, severity and poorer health in US adolescents. Dermatitis 25:172\u2013181. https:\/\/doi.org\/10.1097\/DER.0000000000000047","journal-title":"Dermatitis"},{"key":"9075_CR135","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08165-7","author":"LC Hinte","year":"2024","unstructured":"Hinte LC, Castellano-Castillo D, Ghosh A, Melrose K, Gasser E, No\u00e9 F, Massier L, Dong H, Sun W, Hoffmann A, Wolfrum C, Ryd\u00e9n M, Mejhert N, Bl\u00fcher M, von Meyenn F (2024) Adipose tissue retains an epigenetic memory of obesity after weight loss. Nature. 636(8042):457\u2013465. https:\/\/doi.org\/10.1038\/s41586-024-08165-7","journal-title":"Nature"},{"key":"9075_CR136","doi-asserted-by":"crossref","unstructured":"Maidana D, Arroyo-\u00c1lvarez A, Arenas-Loriente A et al (2024) Inflammation as a new therapeutic target among older patients with ischemic heart disease. J Clin Med 13","DOI":"10.3390\/jcm13020363"},{"key":"9075_CR137","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1007\/s12016-024-08995-3","volume":"66","author":"Y Chen","year":"2024","unstructured":"Chen Y, Peng C, Zhu L et al (2024) Atopic dermatitis and psoriasis: similarities and differences in metabolism and microbiome. Clin Rev Allergy Immunol 66:294\u2013315. https:\/\/doi.org\/10.1007\/s12016-024-08995-3","journal-title":"Clin Rev Allergy Immunol"},{"key":"9075_CR138","doi-asserted-by":"crossref","unstructured":"Tsai YC, Tsai TF (2022) Overlapping features of psoriasis and atopic dermatitis: from genetics to immunopathogenesis to phenotypes. Int J Mol Sci 23","DOI":"10.3390\/ijms23105518"},{"key":"9075_CR139","doi-asserted-by":"publisher","unstructured":"Gerosa S, De Felici Del Giudice MB, Macchi S et al (2024) Overlap of psoriasis and atopic dermatitis in patients with comorbidities: a difficult therapeutic challenge. Italian J Dermatol\u00a0 Venereol. https:\/\/doi.org\/10.23736\/s2784-8671.24.07937-4","DOI":"10.23736\/s2784-8671.24.07937-4"},{"key":"9075_CR140","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jid.2023.06.194","volume":"144","author":"JE Kim","year":"2024","unstructured":"Kim JE, Lee J, Huh YJ et al (2024) Genomic profiling of the overlap phenotype between psoriasis and atopic dermatitis. J Investig Dermatol 144:43-52.e6. https:\/\/doi.org\/10.1016\/j.jid.2023.06.194","journal-title":"J Investig Dermatol"},{"key":"9075_CR141","doi-asserted-by":"publisher","unstructured":"Bozek A, Zajac M, Krupka M (2020) Atopic dermatitis and psoriasis as overlapping syndromes. Mediators Inflamm 2020.\u00a0https:\/\/doi.org\/10.1155\/2020\/7527859","DOI":"10.1155\/2020\/7527859"},{"key":"9075_CR142","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.coi.2017.08.008","volume":"48","author":"E Guttman-Yassky","year":"2017","unstructured":"Guttman-Yassky E, Krueger JG (2017) Atopic dermatitis and psoriasis: two different immune diseases or one spectrum? Curr Opin Immunol 48:68\u201373. https:\/\/doi.org\/10.1016\/j.coi.2017.08.008","journal-title":"Curr Opin Immunol"},{"key":"9075_CR143","doi-asserted-by":"publisher","unstructured":"Zhou Z, Meng L, Cai Y et al (2022) Exploration of the potential mechanism of the common differentially expressed genes in psoriasis and atopic dermatitis. Biomed Res Int 2022. https:\/\/doi.org\/10.1155\/2022\/1177299","DOI":"10.1155\/2022\/1177299"},{"key":"9075_CR144","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.ajhg.2014.12.004","volume":"96","author":"H Baurecht","year":"2015","unstructured":"Baurecht H, Hotze M, Brand S et al (2015) Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms. Am J Hum Genet 96:104\u2013120. https:\/\/doi.org\/10.1016\/j.ajhg.2014.12.004","journal-title":"Am J Hum Genet"},{"key":"9075_CR145","doi-asserted-by":"publisher","first-page":"4841","DOI":"10.1093\/hmg\/ddt317","volume":"22","author":"S Weidinger","year":"2013","unstructured":"Weidinger S, Willis-Owen SAG, Kamatani Y et al (2013) A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis. Hum Mol Genet 22:4841\u20134856. https:\/\/doi.org\/10.1093\/hmg\/ddt317","journal-title":"Hum Mol Genet"},{"key":"9075_CR146","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1038\/s41590-018-0256-2","volume":"19","author":"T Dainichi","year":"2018","unstructured":"Dainichi T, Kitoh A, Otsuka A et al (2018) The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis. Nat Immunol 19:1286\u20131298. https:\/\/doi.org\/10.1038\/s41590-018-0256-2","journal-title":"Nat Immunol"},{"key":"9075_CR147","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1007\/s10753-021-01608-7","volume":"45","author":"MP Corr\u00eaa","year":"2022","unstructured":"Corr\u00eaa MP, Correia-Silva RD, Sasso GRS et al (2022) Expression pattern and immunoregulatory roles of galectin-1 and galectin-3 in atopic dermatitis and psoriasis. Inflammation 45:1133\u20131145. https:\/\/doi.org\/10.1007\/s10753-021-01608-7","journal-title":"Inflammation"},{"key":"9075_CR148","doi-asserted-by":"publisher","first-page":"922","DOI":"10.2353\/ajpath.2009.080500","volume":"174","author":"J Saegusa","year":"2009","unstructured":"Saegusa J, Hsu DK, Chen H-Y et al (2009) Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis. Am J Pathol 174:922\u2013931. https:\/\/doi.org\/10.2353\/ajpath.2009.080500","journal-title":"Am J Pathol"},{"key":"9075_CR149","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/exd.13512","volume":"27","author":"N Wu","year":"2018","unstructured":"Wu N, Liu F (2018) The expression and function of galectins in skin physiology and pathology. Exp Dermatol 27:217\u2013226. https:\/\/doi.org\/10.1111\/exd.13512","journal-title":"Exp Dermatol"},{"key":"9075_CR150","doi-asserted-by":"publisher","unstructured":"Borgia F, Custurone P, Peterle L et al (2021) Role of epithelium-derived cytokines in atopic dermatitis and psoriasis: evidence and therapeutic perspectives. Biomolecules 11. https:\/\/doi.org\/10.3390\/biom11121843","DOI":"10.3390\/biom11121843"},{"key":"9075_CR151","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1080\/09546634.2019.1702147","volume":"32","author":"K Barry","year":"2021","unstructured":"Barry K, Zancanaro P, Casseres R et al (2021) Concomitant atopic dermatitis and psoriasis\u2013a retrospective review. J Dermatol Treat 32:716\u2013720. https:\/\/doi.org\/10.1080\/09546634.2019.1702147","journal-title":"J Dermatol Treat"},{"key":"9075_CR152","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1111\/cod.13572","volume":"83","author":"K Politiek","year":"2020","unstructured":"Politiek K, Loman L, Pas HH et al (2020) Hyperkeratotic hand eczema: eczema or not? Contact Dermatitis 83:196\u2013205. https:\/\/doi.org\/10.1111\/cod.13572","journal-title":"Contact Dermatitis"},{"key":"9075_CR153","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/cod.14035","volume":"86","author":"JP Thyssen","year":"2022","unstructured":"Thyssen JP, Schuttelaar MLA, Alfonso JH et al (2022) Guidelines for diagnosis, prevention, and treatment of hand eczema. Contact Dermatitis 86:357\u2013378. https:\/\/doi.org\/10.1111\/cod.14035","journal-title":"Contact Dermatitis"},{"key":"9075_CR154","doi-asserted-by":"publisher","first-page":"e557","DOI":"10.1111\/jdv.18805","volume":"37","author":"CM Olesen","year":"2023","unstructured":"Olesen CM, Y\u00fcksel YT, Zachariae C et al (2023) Treatment of chronic hand eczema with dupilumab\u2014a retrospective follow-up study. J Eur Acad Dermatol Venereol 37:e557\u2013e559","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"9075_CR155","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/j.1540-9740.2005.03636.x","volume":"4","author":"W Abramovits","year":"2005","unstructured":"Abramovits W, Cockerell C, Stevenson LC, Goldstein AM, Ehrig T, Menter A (2005) PsEma--a hitherto unnamed dermatologic entity with clinical features of both psoriasis and eczema. Skinmed 4(5):275\u201381. https:\/\/doi.org\/10.1111\/j.1540-9740.2005.03636.x","journal-title":"Skinmed"},{"key":"9075_CR156","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17100","author":"A Docampo-Sim\u00f3n","year":"2024","unstructured":"Docampo-Sim\u00f3n A, Belinch\u00f3n I, S\u00e1nchez-Pujol MJ et al (2024) Psoriasis dermatitis, a common phenotype of early forms of both psoriasis and atopic dermatitis in children: a prospective multicenter study. Int J Dermatol. https:\/\/doi.org\/10.1111\/ijd.17100","journal-title":"Int J Dermatol"},{"key":"9075_CR157","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1111\/j.1440-0960.2012.00878.x","volume":"53","author":"S Kapila","year":"2012","unstructured":"Kapila S, Hong E, Fischer G (2012) A comparative study of childhood psoriasis and atopic dermatitis and greater understanding of the overlapping condition, psoriasis-dermatitis. Australas J Dermatol 53:98\u2013105. https:\/\/doi.org\/10.1111\/j.1440-0960.2012.00878.x","journal-title":"Australas J Dermatol"},{"key":"9075_CR158","doi-asserted-by":"crossref","unstructured":"Bridgewood C, Newton D, Bragazzi N et al (2021) Unexpected connections of the IL-23\/IL-17 and IL-4\/IL-13 cytokine axes in inflammatory arthritis and enthesitis. Semin Immunol 58","DOI":"10.1016\/j.smim.2021.101520"},{"key":"9075_CR159","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1111\/jdv.16246","volume":"34","author":"A Al-Janabi","year":"2020","unstructured":"Al-Janabi A, Foulkes AC, Mason K et al (2020) Phenotypic switch to eczema in patients receiving biologics for plaque psoriasis: a systematic review. J Eur Acad Dermatol Venereol 34:1440\u20131448. https:\/\/doi.org\/10.1111\/jdv.16246","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"9075_CR160","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/exd.13336","volume":"27","author":"E Guttman-Yassky","year":"2018","unstructured":"Guttman-Yassky E, Krueger JG, Lebwohl MG (2018) Systemic immune mechanisms in atopic dermatitis and psoriasis with implications for treatment. Exp Dermatol 27:409\u2013417. https:\/\/doi.org\/10.1111\/exd.13336","journal-title":"Exp Dermatol"},{"key":"9075_CR161","doi-asserted-by":"publisher","unstructured":"Roesner LM, Farag AK, Pospich R et al (2022) T-cell receptor sequencing specifies psoriasis as a systemic and atopic dermatitis as a skin-focused, allergen-driven disease. Allergy: European J Allergy Clin Immunol 77:2737\u20132747. https:\/\/doi.org\/10.1111\/all.15272","DOI":"10.1111\/all.15272"}],"container-title":["Clinical Reviews in Allergy &amp; Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-025-09075-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12016-025-09075-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-025-09075-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T11:48:24Z","timestamp":1757245704000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12016-025-09075-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,16]]},"references-count":161,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["9075"],"URL":"https:\/\/doi.org\/10.1007\/s12016-025-09075-w","relation":{},"ISSN":["1559-0267"],"issn-type":[{"value":"1559-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,16]]},"assertion":[{"value":"24 June 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"66"}}