{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:47:55Z","timestamp":1790887675170,"version":"4.1.0"},"reference-count":213,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201144"],"award-info":[{"award-number":["82201144"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171018"],"award-info":[{"award-number":["82171018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the R&D Program of Beijing Municipal Education Commission","award":["KZ20231002543"],"award-info":[{"award-number":["KZ20231002543"]}]},{"name":"the Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes","award":["PWD&RPP-MRI\uff0cJYY2023-6"],"award-info":[{"award-number":["PWD&RPP-MRI\uff0cJYY2023-6"]}]},{"name":"the program for Youth Beijing Scholar 2020","award":["022"],"award-info":[{"award-number":["022"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clinic Rev Allerg Immunol"],"DOI":"10.1007\/s12016-025-09098-3","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T05:15:59Z","timestamp":1756444559000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Decoding Allergic Conjunctivitis: Latest Perspectives on Etiological Drivers and Immunopathological Mechanisms"],"prefix":"10.1007","volume":"68","author":[{"given":"Jiayu","family":"Bao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2649-8241","authenticated-orcid":false,"given":"Ying","family":"Jie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"9098_CR1","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.alit.2020.06.004","volume":"69","author":"D Miyazaki","year":"2020","unstructured":"Miyazaki D, Fukagawa K, Okamoto S, Fukushima A, Uchio E, Ebihara N, Shoji J, Namba K, Shimizu Y (2020) Epidemiological aspects of allergic conjunctivitis. Allergol Int 69:487\u2013495. https:\/\/doi.org\/10.1016\/j.alit.2020.06.004","journal-title":"Allergol Int"},{"key":"9098_CR2","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1097\/aci.0000000000000204","volume":"15","author":"A Leonardi","year":"2015","unstructured":"Leonardi A, Castegnaro A, Valerio AL, Lazzarini D (2015) Epidemiology of allergic conjunctivitis: clinical appearance and treatment patterns in a population-based study. Curr Opin Allergy Clin Immunol 15:482\u2013488. https:\/\/doi.org\/10.1097\/aci.0000000000000204","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"9098_CR3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s10792-025-03443-3","volume":"45","author":"X Dou","year":"2025","unstructured":"Dou X, Zhang W, Zhang X (2025) Exploring the immunological underpinnings of allergic conjunctivitis: the role of CD4 + T Cells and SLAM expression in ocular surface disease. Int Ophthalmol 45:77. https:\/\/doi.org\/10.1007\/s10792-025-03443-3","journal-title":"Int Ophthalmol"},{"key":"9098_CR4","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1097\/aci.0000000000000676","volume":"20","author":"N Erdinest","year":"2020","unstructured":"Erdinest N, London N, Solomon A (2020) Chemokines in allergic conjunctivitis. Curr Opin Allergy Clin Immunol 20:516\u2013527. https:\/\/doi.org\/10.1097\/aci.0000000000000676","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"9098_CR5","doi-asserted-by":"publisher","first-page":"e0169209","DOI":"10.1371\/journal.pone.0169209","volume":"12","author":"H Lee","year":"2017","unstructured":"Lee H, Kim EK, Kim HY, Kim TI (2017) Effects of exposure to ozone on the ocular surface in an experimental model of allergic conjunctivitis. PLoS ONE 12:e0169209. https:\/\/doi.org\/10.1371\/journal.pone.0169209","journal-title":"PLoS ONE"},{"key":"9098_CR6","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1097\/ACI.0b013e328357a21b","volume":"12","author":"MT Irkec","year":"2012","unstructured":"Irkec MT, Bozkurt B (2012) Molecular immunology of allergic conjunctivitis. Curr Opin Allergy Clin Immunol 12:534\u2013539. https:\/\/doi.org\/10.1097\/ACI.0b013e328357a21b","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"9098_CR7","doi-asserted-by":"publisher","first-page":"18205","DOI":"10.1038\/s41598-019-54841-4","volume":"9","author":"D Miyazaki","year":"2019","unstructured":"Miyazaki D, Fukagawa K, Fukushima A, Fujishima H, Uchio E, Ebihara N, Shoji J, Takamura E, Namba K, Ohashi Y et al (2019) Air pollution significantly associated with severe ocular allergic inflammatory diseases. Sci Rep 9:18205. https:\/\/doi.org\/10.1038\/s41598-019-54841-4","journal-title":"Sci Rep"},{"key":"9098_CR8","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/s41377-021-00630-6","volume":"10","author":"CW Lu","year":"2021","unstructured":"Lu CW, Fu J, Liu XF, Chen WW, Hao JL, Li XL, Pant OP (2021) Air pollution and meteorological conditions significantly contribute to the worsening of allergic conjunctivitis: a regional 20-city, 5-year study in Northeast China. Light Sci Appl 10:190. https:\/\/doi.org\/10.1038\/s41377-021-00630-6","journal-title":"Light Sci Appl"},{"key":"9098_CR9","doi-asserted-by":"publisher","unstructured":"Sutton B (2024) Revealed at last: Structure of the antibody-receptor complex common to all IgE-mediated allergic hypersensitivity reactions. Sci Signal 17:eadu0382. https:\/\/doi.org\/10.1126\/scisignal.adu0382","DOI":"10.1126\/scisignal.adu0382"},{"key":"9098_CR10","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1016\/j.jaci.2016.04.010","volume":"137","author":"TAE Platts-Mills","year":"2016","unstructured":"Platts-Mills TAE, Schuyler AJ, Erwin EA, Commins SP, Woodfolk JA (2016) IgE in the diagnosis and treatment of allergic disease. J Allergy Clin Immunol 137:1662\u20131670. https:\/\/doi.org\/10.1016\/j.jaci.2016.04.010","journal-title":"J Allergy Clin Immunol"},{"key":"9098_CR11","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.tips.2012.06.002","volume":"33","author":"DW MacGlashan Jr","year":"2012","unstructured":"MacGlashan DW Jr (2012) IgE-dependent signaling as a therapeutic target for allergies. Trends Pharmacol Sci 33:502\u2013509. https:\/\/doi.org\/10.1016\/j.tips.2012.06.002","journal-title":"Trends Pharmacol Sci"},{"key":"9098_CR12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.rmed.2011.09.007","volume":"106","author":"K Amin","year":"2012","unstructured":"Amin K (2012) The role of mast cells in allergic inflammation. Respir Med 106:9\u201314. https:\/\/doi.org\/10.1016\/j.rmed.2011.09.007","journal-title":"Respir Med"},{"key":"9098_CR13","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s11882-018-0786-6","volume":"18","author":"TE Velez","year":"2018","unstructured":"Velez TE, Bryce PJ, Hulse KE (2018) Mast cell interactions and crosstalk in regulating allergic inflammation. Curr Allergy Asthma Rep 18:30. https:\/\/doi.org\/10.1007\/s11882-018-0786-6","journal-title":"Curr Allergy Asthma Rep"},{"key":"9098_CR14","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1001\/jamadermatol.2018.4061","volume":"155","author":"S Thorsteinsdottir","year":"2019","unstructured":"Thorsteinsdottir S, Stokholm J, Thyssen JP, N\u00f8rgaard S, Thorsen J, Chawes BL, B\u00f8nnelykke K, Waage J, Bisgaard H (2019) Genetic, clinical, and environmental factors associated with persistent atopic dermatitis in childhood. JAMA Dermatol 155:50\u201357. https:\/\/doi.org\/10.1001\/jamadermatol.2018.4061","journal-title":"JAMA Dermatol"},{"key":"9098_CR15","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1177\/039463201102400204","volume":"24","author":"A Saggini","year":"2011","unstructured":"Saggini A, Maccauro G, Tripodi D, De Lutiis MA, Conti F, Felaco P, Fulcheri M, Galzio R, Caraffa A, Antinolfi P et al (2011) Allergic inflammation: role of cytokines with special emphasis on IL-4. Int J Immunopathol Pharmacol 24:305\u2013311. https:\/\/doi.org\/10.1177\/039463201102400204","journal-title":"Int J Immunopathol Pharmacol"},{"key":"9098_CR16","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1586\/1744666x.2014.967684","volume":"10","author":"A Cianferoni","year":"2014","unstructured":"Cianferoni A, Spergel J (2014) The importance of TSLP in allergic disease and its role as a potential therapeutic target. Expert Rev Clin Immunol 10:1463\u20131474. https:\/\/doi.org\/10.1586\/1744666x.2014.967684","journal-title":"Expert Rev Clin Immunol"},{"key":"9098_CR17","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1038\/s41467-017-01220-0","volume":"8","author":"I Marenholz","year":"2017","unstructured":"Marenholz I, Grosche S, Kalb B, R\u00fcschendorf F, Bl\u00fcmchen K, Schlags R, Harandi N, Price M, Hansen G, Seidenberg J et al (2017) Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy. Nat Commun 8:1056. https:\/\/doi.org\/10.1038\/s41467-017-01220-0","journal-title":"Nat Commun"},{"key":"9098_CR18","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/cea.12327","volume":"45","author":"MA Portelli","year":"2015","unstructured":"Portelli MA, Hodge E, Sayers I (2015) Genetic risk factors for the development of allergic disease identified by genome-wide association. Clin Exp Allergy 45:21\u201331. https:\/\/doi.org\/10.1111\/cea.12327","journal-title":"Clin Exp Allergy"},{"key":"9098_CR19","doi-asserted-by":"publisher","first-page":"65","DOI":"10.5505\/ktd.2024.65642","volume":"13","author":"\u00d6 Atik","year":"2024","unstructured":"Atik \u00d6, Tepetam FM, \u00d6zden \u015e, Arslan S (2024) Determination of clinical and demographic characteristics in patients with primary antibody deficiency evaluated in immunology and allergy clinic. Kocaeli Med J 13:65\u201370. https:\/\/doi.org\/10.5505\/ktd.2024.65642","journal-title":"Kocaeli Med J"},{"key":"9098_CR20","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1111\/ced.13113","volume":"42","author":"XW Wang","year":"2017","unstructured":"Wang XW, Wang JJ, Gutowska-Owsiak D, Salimi M, Selvakumar TA, Gwela A, Chen LY, Wang YJ, Giannoulatou E, Ogg G (2017) Deficiency of filaggrin regulates endogenous cysteine protease activity, leading to impaired skin barrier function. Clin Exp Dermatol 42:622\u2013631. https:\/\/doi.org\/10.1111\/ced.13113","journal-title":"Clin Exp Dermatol"},{"key":"9098_CR21","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1002\/eji.201646421","volume":"46","author":"S Sehra","year":"2016","unstructured":"Sehra S, Krishnamurthy P, Koh B, Zhou HM, Seymour L, Akhtar N, Travers JB, Turner MJ, Kaplan MH (2016) Increased Th2 activity and diminished skin barrier function cooperate in allergic skin inflammation. Eur J Immunol 46:2609\u20132613. https:\/\/doi.org\/10.1002\/eji.201646421","journal-title":"Eur J Immunol"},{"key":"9098_CR22","doi-asserted-by":"publisher","unstructured":"Yang G, Seok JK, Kang HC, Cho YY, Lee HS, Lee JY (2020) Skin barrier abnormalities and immune dysfunction in atopic dermatitis. Int J Mol Sci 21. https:\/\/doi.org\/10.3390\/ijms21082867","DOI":"10.3390\/ijms21082867"},{"key":"9098_CR23","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nature13207","volume":"510","author":"M Reyes-Fox","year":"2014","unstructured":"Reyes-Fox M, Steltzer H, Trlica MJ, McMaster GS, Andales AA, LeCain DR, Morgan JA (2014) Elevated CO2 further lengthens growing season under warming conditions. Nature 510:259\u2013262. https:\/\/doi.org\/10.1038\/nature13207","journal-title":"Nature"},{"key":"9098_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.154882","volume":"831","author":"B Adams-Groom","year":"2022","unstructured":"Adams-Groom B, Selby K, Derrett S, Frisk CA, Pashley CH, Satchwell J, King D, McKenzie G, Neilson R (2022) Pollen season trends as markers of climate change impact: Betula. Quercus and Poaceae Sci Total Environ 831:154882. https:\/\/doi.org\/10.1016\/j.scitotenv.2022.154882","journal-title":"Quercus and Poaceae Sci Total Environ"},{"key":"9098_CR25","doi-asserted-by":"publisher","first-page":"160879","DOI":"10.1016\/j.scitotenv.2022.160879","volume":"864","author":"S Nickovic","year":"2023","unstructured":"Nickovic S, Petkovi\u0107 S, Ili\u0107 L, Pejanovi\u0107 G, Miji\u0107 Z, Huete A, Marks G (2023) Prediction of airborne pollen and sub-pollen particles for thunderstorm asthma outbreaks assessment. Sci Total Environ 864:160879. https:\/\/doi.org\/10.1016\/j.scitotenv.2022.160879","journal-title":"Sci Total Environ"},{"key":"9098_CR26","doi-asserted-by":"publisher","first-page":"101","DOI":"10.2147\/jaa.S175155","volume":"12","author":"NS Harun","year":"2019","unstructured":"Harun NS, Lachapelle P, Douglass J (2019) Thunderstorm-triggered asthma: what we know so far. J Asthma Allergy 12:101\u2013108. https:\/\/doi.org\/10.2147\/jaa.S175155","journal-title":"J Asthma Allergy"},{"key":"9098_CR27","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1038\/s41467-022-28764-0","volume":"13","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Steiner AL (2022) Projected climate-driven changes in pollen emission season length and magnitude over the continental United States. Nat Commun 13:1234. https:\/\/doi.org\/10.1038\/s41467-022-28764-0","journal-title":"Nat Commun"},{"key":"9098_CR28","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/2049-6958-6-1-28","volume":"6","author":"G D'Amato","year":"2011","unstructured":"D\u2019Amato G (2011) Effects of climatic changes and urban air pollution on the rising trends of respiratory allergy and asthma. Multidiscip Respir Med 6:28\u201337. https:\/\/doi.org\/10.1186\/2049-6958-6-1-28","journal-title":"Multidiscip Respir Med"},{"key":"9098_CR29","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s11882-009-0046-x","volume":"9","author":"L Viera","year":"2009","unstructured":"Viera L, Chen K, Nel A, Lloret MG (2009) The impact of air pollutants as an adjuvant for allergic sensitization and asthma. Curr Allergy Asthma Rep 9:327\u2013333. https:\/\/doi.org\/10.1007\/s11882-009-0046-x","journal-title":"Curr Allergy Asthma Rep"},{"key":"9098_CR30","doi-asserted-by":"publisher","first-page":"123488","DOI":"10.1016\/j.envpol.2024.123488","volume":"345","author":"P Upaphong","year":"2024","unstructured":"Upaphong P, Thonusin C, Wanichthanaolan O, Chattipakorn N, Chattipakorn SC (2024) Consequences of exposure to particulate matter on the ocular surface: Mechanistic insights from cellular mechanisms to epidemiological findings. Environ Pollut 345:123488. https:\/\/doi.org\/10.1016\/j.envpol.2024.123488","journal-title":"Environ Pollut"},{"key":"9098_CR31","doi-asserted-by":"publisher","first-page":"13636","DOI":"10.1021\/acs.est.4c01791","volume":"58","author":"Y Qi","year":"2024","unstructured":"Qi Y, Liu X, Chen Y, Wu Y, Sun Y, Liu X, Bao Q, Zhang J, Yuan G, Wang T et al (2024) Enhanced intrusion of exogenous airborne fine particles toward eyes in humans and animals: where damaged blood-ocular barrier plays a crucial role. Environ Sci Technol 58:13636\u201313647. https:\/\/doi.org\/10.1021\/acs.est.4c01791","journal-title":"Environ Sci Technol"},{"key":"9098_CR32","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.envres.2018.07.013","volume":"167","author":"AI Tesone","year":"2018","unstructured":"Tesone AI, Lasagni Vitar RM, Tau J, Maglione GA, Llesuy S, Tasat DR, Berra A (2018) Volcanic ash from Puyehue-Cord\u00f3n Caulle Volcanic Complex and Calbuco promote a differential response of pro-inflammatory and oxidative stress mediators on human conjunctival epithelial cells. Environ Res 167:87\u201397. https:\/\/doi.org\/10.1016\/j.envres.2018.07.013","journal-title":"Environ Res"},{"key":"9098_CR33","doi-asserted-by":"publisher","first-page":"1325956","DOI":"10.3389\/fpubh.2024.1325956","volume":"12","author":"D Liu","year":"2024","unstructured":"Liu D, Gui S, Wang X, Wang Q, Qiao J, Tao F, Tao L, Jiang Z, Yi X (2024) Long-term effects of air pollution on daily outpatient visits for allergic conjunctivitis from 2013 to 2020: a time-series study in Urumqi China. Front Public Health 12:1325956. https:\/\/doi.org\/10.3389\/fpubh.2024.1325956","journal-title":"Front Public Health"},{"key":"9098_CR34","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.scitotenv.2014.04.057","volume":"487","author":"T Mimura","year":"2014","unstructured":"Mimura T, Ichinose T, Yamagami S, Fujishima H, Kamei Y, Goto M, Takada S, Matsubara M (2014) Airborne particulate matter (PM2.5) and the prevalence of allergic conjunctivitis in Japan. Sci Total Environ 487:493\u2013499. https:\/\/doi.org\/10.1016\/j.scitotenv.2014.04.057","journal-title":"Sci Total Environ"},{"key":"9098_CR35","doi-asserted-by":"publisher","first-page":"3263","DOI":"10.2147\/opth.S485199","volume":"18","author":"JL Patnaik","year":"2024","unstructured":"Patnaik JL, Dye-Robinson A, James KA, Kahook MY (2024) Association between particulate matter pollutants and ophthalmology visits for ocular surface irritation and allergy. Clin Ophthalmol 18:3263\u20133270. https:\/\/doi.org\/10.2147\/opth.S485199","journal-title":"Clin Ophthalmol"},{"key":"9098_CR36","doi-asserted-by":"publisher","first-page":"136032","DOI":"10.1016\/j.jhazmat.2024.136032","volume":"480","author":"Z Ruan","year":"2024","unstructured":"Ruan Z, H\u00f6gd\u00e9n A, Zhang T, Li Y, Xu Y, Wang J, Chai D, Wang Z, Shan W, Liao Y et al (2024) Daily gaseous air pollution and pediatric conjunctivitis: A case-crossover study across ten cities in China\u2019s southeastern coastal region. J Hazard Mater 480:136032. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.136032","journal-title":"J Hazard Mater"},{"key":"9098_CR37","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.coi.2018.06.007","volume":"54","author":"E Haspeslagh","year":"2018","unstructured":"Haspeslagh E, Heyndrickx I, Hammad H, Lambrecht BN (2018) The hygiene hypothesis: immunological mechanisms of airway tolerance. Curr Opin Immunol 54:102\u2013108. https:\/\/doi.org\/10.1016\/j.coi.2018.06.007","journal-title":"Curr Opin Immunol"},{"key":"9098_CR38","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1097\/aci.0000000000000930","volume":"23","author":"KM Cavuoto","year":"2023","unstructured":"Cavuoto KM, Galor A, Zhu AY (2023) Role of the ocular surface microbiome in allergic eye diseases. Curr Opin Allergy Clin Immunol 23:376\u2013382. https:\/\/doi.org\/10.1097\/aci.0000000000000930","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"9098_CR39","doi-asserted-by":"publisher","first-page":"1079154","DOI":"10.3389\/fimmu.2023.1079154","volume":"14","author":"Y Wang","year":"2023","unstructured":"Wang Y, Li X, Gu S, Fu J (2023) Characterization of dysbiosis of the conjunctival microbiome and nasal microbiome associated with allergic rhinoconjunctivitis and allergic rhinitis. Front Immunol 14:1079154. https:\/\/doi.org\/10.3389\/fimmu.2023.1079154","journal-title":"Front Immunol"},{"key":"9098_CR40","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1167\/iovs.15-17340","volume":"57","author":"YJ Lee","year":"2016","unstructured":"Lee YJ, Han SJ, Lee H, Kim JS, Seo KY (2016) Development of allergic conjunctivitis induced by house dust mite extract from dermatophagoides pteronyssinus. Invest Ophthalmol Vis Sci 57:1773\u20131781. https:\/\/doi.org\/10.1167\/iovs.15-17340","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"9098_CR41","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1097\/ICO.0b013e3182000feb","volume":"30","author":"T Mimura","year":"2011","unstructured":"Mimura T, Usui T, Mori M, Funatsu H, Noma H, Yamamoto H, Aixinjueluo W, Amano S (2011) Relation between total tear IgE and specific serum IgE in seasonal allergic conjunctivitis. Cornea 30:790\u2013795. https:\/\/doi.org\/10.1097\/ICO.0b013e3182000feb","journal-title":"Cornea"},{"key":"9098_CR42","doi-asserted-by":"publisher","first-page":"108836","DOI":"10.1016\/j.envint.2024.108836","volume":"190","author":"H Salonen","year":"2024","unstructured":"Salonen H, Salthammer T, Castagnoli E, T\u00e4ubel M, Morawska L (2024) Cleaning products: Their chemistry, effects on indoor air quality, and implications for human health. Environ Int 190:108836. https:\/\/doi.org\/10.1016\/j.envint.2024.108836","journal-title":"Environ Int"},{"key":"9098_CR43","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.4049\/jimmunol.1202889","volume":"191","author":"Y Fukuoka","year":"2013","unstructured":"Fukuoka Y, Hite MR, Dellinger AL, Schwartz LB (2013) Human skin mast cells express complement factors C3 and C5. J Immunol 191:1827\u20131834. https:\/\/doi.org\/10.4049\/jimmunol.1202889","journal-title":"J Immunol"},{"key":"9098_CR44","doi-asserted-by":"publisher","first-page":"615236","DOI":"10.3389\/fimmu.2020.615236","volume":"11","author":"PW West","year":"2020","unstructured":"West PW, Bahri R, Garcia-Rodriguez KM, Sweetland G, Wileman G, Shah R, Montero A, Rapley L, Bulfone-Paus S (2020) Interleukin-33 amplifies human mast cell activities induced by complement anaphylatoxins. Front Immunol 11:615236. https:\/\/doi.org\/10.3389\/fimmu.2020.615236","journal-title":"Front Immunol"},{"key":"9098_CR45","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1080\/08820139.2022.2151368","volume":"52","author":"X Song","year":"2023","unstructured":"Song X, Zhang L, Du X, Zheng Y, Jia T, Zhou T, Che D, Geng S (2023) Neuroblast differentiation-associated protein derived polypeptides: AHNAK(5758\u20135775) Induces inflammation by activating mast cells via ST2. Immunol Invest 52:178\u2013193. https:\/\/doi.org\/10.1080\/08820139.2022.2151368","journal-title":"Immunol Invest"},{"key":"9098_CR46","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1080\/1744666x.2023.2200936","volume":"19","author":"TC Theoharides","year":"2023","unstructured":"Theoharides TC, Perlman AI, Twahir A, Kempuraj D (2023) Mast cell activation: beyond histamine and tryptase. Expert Rev Clin Immunol 19:639\u2013654. https:\/\/doi.org\/10.1080\/1744666x.2023.2200936","journal-title":"Expert Rev Clin Immunol"},{"key":"9098_CR47","doi-asserted-by":"publisher","first-page":"172760","DOI":"10.1016\/j.ejphar.2019.172760","volume":"865","author":"MA Bawazeer","year":"2019","unstructured":"Bawazeer MA, Theoharides TC (2019) IL-33 stimulates human mast cell release of CCL5 and CCL2 via MAPK and NF-\u03baB, inhibited by methoxyluteolin. Eur J Pharmacol 865:172760. https:\/\/doi.org\/10.1016\/j.ejphar.2019.172760","journal-title":"Eur J Pharmacol"},{"key":"9098_CR48","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/imr.12622","volume":"282","author":"K Gupta","year":"2018","unstructured":"Gupta K, Harvima IT (2018) Mast cell-neural interactions contribute to pain and itch. Immunol Rev 282:168\u2013187. https:\/\/doi.org\/10.1111\/imr.12622","journal-title":"Immunol Rev"},{"key":"9098_CR49","doi-asserted-by":"publisher","unstructured":"Wang Y, Zhang X, Liu S, Gu Z, Sun Z, Zang Y, Huang X, Wang Y, Wang Q, Lin Q et al. (2025) Bi-directional communication between intrinsic enteric neurons and ILC2s inhibits host defense against helminth infection. Immunity.https:\/\/doi.org\/10.1016\/j.immuni.2025.01.004","DOI":"10.1016\/j.immuni.2025.01.004"},{"key":"9098_CR50","doi-asserted-by":"publisher","first-page":"1151754","DOI":"10.3389\/fimmu.2023.1151754","volume":"14","author":"E R\u00f6nnberg","year":"2023","unstructured":"R\u00f6nnberg E, Ravindran A, Mazzurana L, Gong Y, S\u00e4fholm J, Lorent J, Dethlefsen O, Orre AC, Al-Ameri M, Adner M et al (2023) Analysis of human lung mast cells by single cell RNA sequencing. Front Immunol 14:1151754. https:\/\/doi.org\/10.3389\/fimmu.2023.1151754","journal-title":"Front Immunol"},{"key":"9098_CR51","doi-asserted-by":"publisher","first-page":"3573142","DOI":"10.1155\/2016\/3573142","volume":"2016","author":"Y Shiraki","year":"2016","unstructured":"Shiraki Y, Shoji J, Inada N (2016) Clinical usefulness of monitoring expression levels of CCL24 (Eotaxin-2) mRNA on the ocular surface in patients with vernal keratoconjunctivitis and atopic keratoconjunctivitis. J Ophthalmol 2016:3573142. https:\/\/doi.org\/10.1155\/2016\/3573142","journal-title":"J Ophthalmol"},{"key":"9098_CR52","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1189\/jlb.0212074","volume":"94","author":"V Provost","year":"2013","unstructured":"Provost V, Larose MC, Langlois A, Rola-Pleszczynski M, Flamand N, Laviolette M (2013) CCL26\/eotaxin-3 is more effective to induce the migration of eosinophils of asthmatics than CCL11\/eotaxin-1 and CCL24\/eotaxin-2. J Leukoc Biol 94:213\u2013222. https:\/\/doi.org\/10.1189\/jlb.0212074","journal-title":"J Leukoc Biol"},{"key":"9098_CR53","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1159\/000236244","volume":"99","author":"PF Weller","year":"1992","unstructured":"Weller PF (1992) Intercellular interactions in the recruitment and functions of human eosinophils. Int Arch Allergy Immunol 99:178\u2013183. https:\/\/doi.org\/10.1159\/000236244","journal-title":"Int Arch Allergy Immunol"},{"key":"9098_CR54","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.jtos.2022.08.004","volume":"26","author":"A Fernandez","year":"2022","unstructured":"Fernandez A, Asbell P, Roy N (2022) Emerging therapies targeting eosinophil-mediated inflammation in chronic allergic conjunctivitis. Ocul Surf 26:191\u2013196. https:\/\/doi.org\/10.1016\/j.jtos.2022.08.004","journal-title":"Ocul Surf"},{"issue":"Suppl 1","key":"9098_CR55","doi-asserted-by":"publisher","first-page":"S62","DOI":"10.1097\/ICO.0b013e3181ea9b2b","volume":"29","author":"K Fukuda","year":"2010","unstructured":"Fukuda K, Nishida T (2010) Ocular allergic inflammation: interaction between the cornea and conjunctiva. Cornea 29(Suppl 1):S62-67. https:\/\/doi.org\/10.1097\/ICO.0b013e3181ea9b2b","journal-title":"Cornea"},{"key":"9098_CR56","doi-asserted-by":"publisher","first-page":"380","DOI":"10.3389\/fimmu.2012.00380","volume":"3","author":"JS Knight","year":"2012","unstructured":"Knight JS, Carmona-Rivera C, Kaplan MJ (2012) Proteins derived from neutrophil extracellular traps may serve as self-antigens and mediate organ damage in autoimmune diseases. Front Immunol 3:380. https:\/\/doi.org\/10.3389\/fimmu.2012.00380","journal-title":"Front Immunol"},{"key":"9098_CR57","doi-asserted-by":"publisher","first-page":"23633","DOI":"10.1002\/jcp.28931","volume":"234","author":"JS Silveira","year":"2019","unstructured":"Silveira JS, Antunes GL, Kaiber DB, da Costa MS, Marques EP, Ferreira FS, Gassen RB, Breda RV, Wyse ATS, Pitrez P, da Cunha AA (2019) Reactive oxygen species are involved in eosinophil extracellular traps release and in airway inflammation in asthma. J Cell Physiol 234:23633\u201323646. https:\/\/doi.org\/10.1002\/jcp.28931","journal-title":"J Cell Physiol"},{"key":"9098_CR58","doi-asserted-by":"publisher","first-page":"4043","DOI":"10.4049\/jimmunol.1400732","volume":"193","author":"PC Fulkerson","year":"2014","unstructured":"Fulkerson PC, Schollaert KL, Bouffi C, Rothenberg ME (2014) IL-5 triggers a cooperative cytokine network that promotes eosinophil precursor maturation. J Immunol 193:4043\u20134052. https:\/\/doi.org\/10.4049\/jimmunol.1400732","journal-title":"J Immunol"},{"key":"9098_CR59","doi-asserted-by":"publisher","first-page":"e24","DOI":"10.4110\/in.2020.20.e24","volume":"20","author":"HJ Kim","year":"2020","unstructured":"Kim HJ, Jung Y (2020) The emerging role of eosinophils as multifunctional leukocytes in health and disease. Immune Netw 20:e24. https:\/\/doi.org\/10.4110\/in.2020.20.e24","journal-title":"Immune Netw"},{"key":"9098_CR60","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.cyto.2015.05.010","volume":"75","author":"J Zhu","year":"2015","unstructured":"Zhu J (2015) T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production. Cytokine 75:14\u201324. https:\/\/doi.org\/10.1016\/j.cyto.2015.05.010","journal-title":"Cytokine"},{"key":"9098_CR61","doi-asserted-by":"publisher","first-page":"945063","DOI":"10.3389\/fimmu.2022.945063","volume":"13","author":"K Kokubo","year":"2022","unstructured":"Kokubo K, Onodera A, Kiuchi M, Tsuji K, Hirahara K, Nakayama T (2022) Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis. Front Immunol 13:945063. https:\/\/doi.org\/10.3389\/fimmu.2022.945063","journal-title":"Front Immunol"},{"key":"9098_CR62","doi-asserted-by":"publisher","first-page":"2352","DOI":"10.1016\/j.immuni.2022.09.016","volume":"55","author":"M Okano","year":"2022","unstructured":"Okano M, Hirahara K, Kiuchi M, Onoue M, Iwamura C, Kokubo K, Hishiya T, Morimoto Y, Ikehara Y, Murakami A et al (2022) Interleukin-33-activated neuropeptide CGRP-producing memory Th2 cells cooperate with somatosensory neurons to induce conjunctival itch. Immunity 55:2352-2368.e2357. https:\/\/doi.org\/10.1016\/j.immuni.2022.09.016","journal-title":"Immunity"},{"key":"9098_CR63","doi-asserted-by":"publisher","first-page":"5116","DOI":"10.4049\/jimmunol.0804213","volume":"182","author":"P Stock","year":"2009","unstructured":"Stock P, Lombardi V, Kohlrautz V, Akbari O (2009) Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB. J Immunol 182:5116\u20135122. https:\/\/doi.org\/10.4049\/jimmunol.0804213","journal-title":"J Immunol"},{"key":"9098_CR64","doi-asserted-by":"publisher","first-page":"4531","DOI":"10.4049\/jimmunol.0903162","volume":"184","author":"L Roussel","year":"2010","unstructured":"Roussel L, Houle F, Chan C, Yao Y, B\u00e9rub\u00e9 J, Olivenstein R, Martin JG, Huot J, Hamid Q, Ferri L, Rousseau S (2010) IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation. J Immunol 184:4531\u20134537. https:\/\/doi.org\/10.4049\/jimmunol.0903162","journal-title":"J Immunol"},{"key":"9098_CR65","doi-asserted-by":"publisher","first-page":"6287","DOI":"10.4049\/jimmunol.1200385","volume":"188","author":"GK Griffin","year":"2012","unstructured":"Griffin GK, Newton G, Tarrio ML, Bu DX, Maganto-Garcia E, Azcutia V, Alcaide P, Grabie N, Luscinskas FW, Croce KJ, Lichtman AH (2012) IL-17 and TNF-\u03b1 sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation. J Immunol 188:6287\u20136299. https:\/\/doi.org\/10.4049\/jimmunol.1200385","journal-title":"J Immunol"},{"key":"9098_CR66","doi-asserted-by":"publisher","unstructured":"Nieto JE, Casanova I, Serna-Ojeda JC, Graue-Hern\u00e1ndez EO, Quintana G, Salazar A, Jim\u00e9nez-Martinez MC (2020) Increased expression of TLR4 in circulating CD4+T cells in patients with allergic conjunctivitis and in vitro attenuation of Th2 inflammatory response by alpha-MSH. Int J Mol Sci 21. https:\/\/doi.org\/10.3390\/ijms21217861","DOI":"10.3390\/ijms21217861"},{"key":"9098_CR67","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s13223-021-00577-8","volume":"17","author":"L Lin","year":"2021","unstructured":"Lin L, Dai F, Wei J, Chen Z (2021) CD8(+) Tregs ameliorate inflammatory reactions in a murine model of allergic rhinitis. Allergy Asthma Clin Immunol 17:74. https:\/\/doi.org\/10.1186\/s13223-021-00577-8","journal-title":"Allergy Asthma Clin Immunol"},{"key":"9098_CR68","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1111\/all.15144","volume":"77","author":"S Tagkareli","year":"2022","unstructured":"Tagkareli S, Salagianni M, Galani IE, Manioudaki M, Pavlos E, Thanopoulou K, Andreakos E (2022) CD103 integrin identifies a high IL-10-producing FoxP3(+) regulatory T-cell population suppressing allergic airway inflammation. Allergy 77:1150\u20131164. https:\/\/doi.org\/10.1111\/all.15144","journal-title":"Allergy"},{"key":"9098_CR69","doi-asserted-by":"publisher","first-page":"6917185","DOI":"10.1155\/2020\/6917185","volume":"2020","author":"XT Meng","year":"2020","unstructured":"Meng XT, Shi YY, Zhang H, Zhou HY (2020) The role of Th17 cells and IL-17 in Th2 immune responses of allergic conjunctivitis. J Ophthalmol 2020:6917185. https:\/\/doi.org\/10.1155\/2020\/6917185","journal-title":"J Ophthalmol"},{"key":"9098_CR70","doi-asserted-by":"publisher","first-page":"5625","DOI":"10.4049\/jimmunol.180.8.5625","volume":"180","author":"PF Cheung","year":"2008","unstructured":"Cheung PF, Wong CK, Lam CW (2008) Molecular mechanisms of cytokine and chemokine release from eosinophils activated by IL-17A, IL-17F, and IL-23: implication for Th17 lymphocytes-mediated allergic inflammation. J Immunol 180:5625\u20135635. https:\/\/doi.org\/10.4049\/jimmunol.180.8.5625","journal-title":"J Immunol"},{"key":"9098_CR71","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1038\/cmi.2012.31","volume":"9","author":"DM Kemeny","year":"2012","unstructured":"Kemeny DM (2012) The role of the T follicular helper cells in allergic disease. Cell Mol Immunol 9:386\u2013389. https:\/\/doi.org\/10.1038\/cmi.2012.31","journal-title":"Cell Mol Immunol"},{"key":"9098_CR72","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1111\/all.14639","volume":"76","author":"Y Yao","year":"2021","unstructured":"Yao Y, Chen CL, Yu D, Liu Z (2021) Roles of follicular helper and regulatory T cells in allergic diseases and allergen immunotherapy. Allergy 76:456\u2013470. https:\/\/doi.org\/10.1111\/all.14639","journal-title":"Allergy"},{"key":"9098_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/09168451.2015.1056512","volume":"80","author":"W Ise","year":"2016","unstructured":"Ise W (2016) Development and function of follicular helper T cells. Biosci Biotechnol Biochem 80:1\u20136. https:\/\/doi.org\/10.1080\/09168451.2015.1056512","journal-title":"Biosci Biotechnol Biochem"},{"key":"9098_CR74","doi-asserted-by":"publisher","first-page":"e70011","DOI":"10.1111\/imr.70011","volume":"330","author":"M Gauthier","year":"2025","unstructured":"Gauthier M, Kale SL, Ray A (2025) T1\u2013T2 interplay in the complex immune landscape of severe asthma. Immunol Rev 330:e70011. https:\/\/doi.org\/10.1111\/imr.70011","journal-title":"Immunol Rev"},{"issue":"Suppl 1","key":"9098_CR75","doi-asserted-by":"publisher","first-page":"S47","DOI":"10.1097\/ico.0000000000002548","volume":"39","author":"Y Asada","year":"2020","unstructured":"Asada Y (2020) Roles of type 2 immune response-initiating cytokines and detection of type 2 innate lymphoid cells in mouse models of allergic conjunctivitis. Cornea 39(Suppl 1):S47-s50. https:\/\/doi.org\/10.1097\/ico.0000000000002548","journal-title":"Cornea"},{"key":"9098_CR76","doi-asserted-by":"publisher","first-page":"5194","DOI":"10.1167\/iovs.15-16563","volume":"56","author":"Y Asada","year":"2015","unstructured":"Asada Y, Nakae S, Ishida W, Hori K, Sugita J, Sudo K, Fukuda K, Fukushima A, Suto H, Murakami A et al (2015) Roles of epithelial cell-derived type 2-initiating cytokines in experimental allergic conjunctivitis. Invest Ophthalmol Vis Sci 56:5194\u20135202. https:\/\/doi.org\/10.1167\/iovs.15-16563","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"9098_CR77","doi-asserted-by":"publisher","first-page":"911022","DOI":"10.3389\/fimmu.2022.911022","volume":"13","author":"JC Zarzuela","year":"2022","unstructured":"Zarzuela JC, Reinoso R, Armentia A, Enr\u00edquez-de-Salamanca A, Corell A (2022) Conjunctival intraepithelial lymphocytes, lacrimal cytokines and ocular commensal microbiota: analysis of the three main players in allergic conjunctivitis. Front Immunol 13:911022. https:\/\/doi.org\/10.3389\/fimmu.2022.911022","journal-title":"Front Immunol"},{"key":"9098_CR78","doi-asserted-by":"publisher","first-page":"339","DOI":"10.4193\/Rhin17.065","volume":"55","author":"L Lin","year":"2017","unstructured":"Lin L, Dai F, Wei JJ, Tang XY, Chen Z, Sun GB (2017) Allergic inflammation is exacerbated by allergen-induced type 2 innate lymphoid cells in a murine model of allergic rhinitis. Rhinology 55:339\u2013347. https:\/\/doi.org\/10.4193\/Rhin17.065","journal-title":"Rhinology"},{"key":"9098_CR79","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s11882-017-0735-9","volume":"17","author":"L Cosmi","year":"2017","unstructured":"Cosmi L, Liotta F, Maggi L, Annunziato F (2017) Role of type 2 innate lymphoid cells in allergic diseases. Curr Allergy Asthma Rep 17:66. https:\/\/doi.org\/10.1007\/s11882-017-0735-9","journal-title":"Curr Allergy Asthma Rep"},{"key":"9098_CR80","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/j.jaci.2021.03.015","volume":"147","author":"KR Bartemes","year":"2021","unstructured":"Bartemes KR, Kita H (2021) Roles of innate lymphoid cells (ILCs) in allergic diseases: The 10-year anniversary for ILC2s. J Allergy Clin Immunol 147:1531\u20131547. https:\/\/doi.org\/10.1016\/j.jaci.2021.03.015","journal-title":"J Allergy Clin Immunol"},{"key":"9098_CR81","doi-asserted-by":"publisher","first-page":"586078","DOI":"10.3389\/fimmu.2021.586078","volume":"12","author":"H Zheng","year":"2021","unstructured":"Zheng H, Zhang Y, Pan J, Liu N, Qin Y, Qiu L, Liu M, Wang T (2021) The role of type 2 innate lymphoid cells in allergic diseases. Front Immunol 12:586078. https:\/\/doi.org\/10.3389\/fimmu.2021.586078","journal-title":"Front Immunol"},{"key":"9098_CR82","doi-asserted-by":"publisher","unstructured":"Sun Z, Vattepu R, Zhang S (2021) Chemokines and innate lymphoid cells in skin inflammation. Cells 10. https:\/\/doi.org\/10.3390\/cells10113074","DOI":"10.3390\/cells10113074"},{"key":"9098_CR83","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.immuni.2014.01.011","volume":"40","author":"TY Halim","year":"2014","unstructured":"Halim TY, Steer CA, Math\u00e4 L, Gold MJ, Martinez-Gonzalez I, McNagny KM, McKenzie AN, Takei F (2014) Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation. Immunity 40:425\u2013435. https:\/\/doi.org\/10.1016\/j.immuni.2014.01.011","journal-title":"Immunity"},{"key":"9098_CR84","doi-asserted-by":"publisher","first-page":"5139","DOI":"10.1038\/s41467-020-18781-2","volume":"11","author":"SP Sajuthi","year":"2020","unstructured":"Sajuthi SP, DeFord P, Li Y, Jackson ND, Montgomery MT, Everman JL, Rios CL, Pruesse E, Nolin JD, Plender EG et al (2020) Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium. Nat Commun 11:5139. https:\/\/doi.org\/10.1038\/s41467-020-18781-2","journal-title":"Nat Commun"},{"key":"9098_CR85","doi-asserted-by":"publisher","first-page":"14305","DOI":"10.1038\/s41598-019-50308-8","volume":"9","author":"S Bonne-Ann\u00e9e","year":"2019","unstructured":"Bonne-Ann\u00e9e S, Bush MC, Nutman TB (2019) Differential modulation of human Innate Lymphoid Cell (ILC) subsets by IL-10 and TGF-\u03b2. Sci Rep 9:14305. https:\/\/doi.org\/10.1038\/s41598-019-50308-8","journal-title":"Sci Rep"},{"issue":"Suppl 1","key":"9098_CR86","doi-asserted-by":"publisher","first-page":"S95","DOI":"10.1513\/AnnalsATS.201508-557MG","volume":"13","author":"H Kabata","year":"2016","unstructured":"Kabata H, Moro K, Koyasu S, Fukunaga K, Asano K, Betsuyaku T (2016) Mechanisms to suppress ILC2-induced airway inflammation. Ann Am Thorac Soc 13(Suppl 1):S95. https:\/\/doi.org\/10.1513\/AnnalsATS.201508-557MG","journal-title":"Ann Am Thorac Soc"},{"key":"9098_CR87","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cellimm.2019.02.006","volume":"338","author":"HK Yoon","year":"2019","unstructured":"Yoon HK, Shim YS, Kim PH, Park SR (2019) The TLR7 agonist imiquimod selectively inhibits IL-4-induced IgE production by suppressing IgG1\/IgE class switching and germline \u03b5 transcription through the induction of BCL6 expression in B cells. Cell Immunol 338:1\u20138. https:\/\/doi.org\/10.1016\/j.cellimm.2019.02.006","journal-title":"Cell Immunol"},{"key":"9098_CR88","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.4049\/jimmunol.1300909","volume":"192","author":"E Janssen","year":"2014","unstructured":"Janssen E, Ozcan E, Liadaki K, Jabara HH, Manis J, Ullas S, Akira S, Fitzgerald KA, Golenbock DT, Geha RS (2014) TRIF signaling is essential for TLR4-driven IgE class switching. J Immunol 192:2651\u20132658. https:\/\/doi.org\/10.4049\/jimmunol.1300909","journal-title":"J Immunol"},{"key":"9098_CR89","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s00281-016-0568-y","volume":"38","author":"Y Yamanishi","year":"2016","unstructured":"Yamanishi Y, Karasuyama H (2016) Basophil-derived IL-4 plays versatile roles in immunity. Semin Immunopathol 38:615\u2013622. https:\/\/doi.org\/10.1007\/s00281-016-0568-y","journal-title":"Semin Immunopathol"},{"key":"9098_CR90","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nri.2017.10","volume":"17","author":"O Soehnlein","year":"2017","unstructured":"Soehnlein O, Steffens S, Hidalgo A, Weber C (2017) Neutrophils as protagonists and targets in chronic inflammation. Nat Rev Immunol 17:248\u2013261. https:\/\/doi.org\/10.1038\/nri.2017.10","journal-title":"Nat Rev Immunol"},{"key":"9098_CR91","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.jid.2021.04.014","volume":"142","author":"S Nakabo","year":"2022","unstructured":"Nakabo S, Romo-Tena J, Kaplan MJ (2022) Neutrophils as drivers of immune dysregulation in autoimmune diseases with skin manifestations. J Invest Dermatol 142:823\u2013833. https:\/\/doi.org\/10.1016\/j.jid.2021.04.014","journal-title":"J Invest Dermatol"},{"key":"9098_CR92","first-page":"1280","volume":"16","author":"W Ishida","year":"2010","unstructured":"Ishida W, Fukuda K, Kajisako M, Takahashi A, Sumi T, van Rooijen N, Fukushima A (2010) Conjunctival macrophages act as antigen-presenting cells in the conjunctiva during the development of experimental allergic conjunctivitis. Mol Vis 16:1280\u20131285","journal-title":"Mol Vis"},{"key":"9098_CR93","doi-asserted-by":"publisher","unstructured":"Fukuda K, Ishida W, Fukushima A, Nishida T (2017) Corneal fibroblasts as sentinel cells and local immune modulators in infectious keratitis. Int J Mol Sci 18. https:\/\/doi.org\/10.3390\/ijms18091831","DOI":"10.3390\/ijms18091831"},{"key":"9098_CR94","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1111\/j.1476-5381.2010.01086.x","volume":"162","author":"FP Mesquita-Santos","year":"2011","unstructured":"Mesquita-Santos FP, Bakker-Abreu I, Luna-Gomes T, Bozza PT, Diaz BL, Bandeira-Melo C (2011) Co-operative signalling through DP(1) and DP(2) prostanoid receptors is required to enhance leukotriene C(4) synthesis induced by prostaglandin D(2) in eosinophils. Br J Pharmacol 162:1674\u20131685. https:\/\/doi.org\/10.1111\/j.1476-5381.2010.01086.x","journal-title":"Br J Pharmacol"},{"key":"9098_CR95","doi-asserted-by":"publisher","first-page":"G908","DOI":"10.1152\/ajpgi.00448.2012","volume":"304","author":"S Zhang","year":"2013","unstructured":"Zhang S, Grabauskas G, Wu X, Joo MK, Heldsinger A, Song I, Owyang C, Yu S (2013) Role of prostaglandin D2 in mast cell activation-induced sensitization of esophageal vagal afferents. Am J Physiol Gastrointest Liver Physiol 304:G908-916. https:\/\/doi.org\/10.1152\/ajpgi.00448.2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"9098_CR96","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/s2213-2600(16)30179-5","volume":"4","author":"S Gonem","year":"2016","unstructured":"Gonem S, Berair R, Singapuri A, Hartley R, Laurencin MFM, Bacher G, Holzhauer B, Bourne M, Mistry V, Pavord ID et al (2016) Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial. Lancet Respir Med 4:699\u2013707. https:\/\/doi.org\/10.1016\/s2213-2600(16)30179-5","journal-title":"Lancet Respir Med"},{"key":"9098_CR97","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s11882-021-01017-8","volume":"21","author":"D Yang","year":"2021","unstructured":"Yang D, Guo X, Liu T, Li Y, Du Z, Liu C (2021) Efficacy and safety of prostaglandin D2 receptor 2 antagonism with fevipiprant for patients with asthma: a systematic review and meta-analysis of randomized controlled trials. Curr Allergy Asthma Rep 21:39. https:\/\/doi.org\/10.1007\/s11882-021-01017-8","journal-title":"Curr Allergy Asthma Rep"},{"key":"9098_CR98","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.ejphar.2016.11.036","volume":"794","author":"T Sekioka","year":"2017","unstructured":"Sekioka T, Kadode M, Yonetomi Y, Kamiya A, Fujita M, Nabe T, Kawabata K (2017) CysLT(2) receptor activation is involved in LTC(4)-induced lung air-trapping in guinea pigs. Eur J Pharmacol 794:147\u2013153. https:\/\/doi.org\/10.1016\/j.ejphar.2016.11.036","journal-title":"Eur J Pharmacol"},{"key":"9098_CR99","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.alit.2014.11.002","volume":"64","author":"H Shirasaki","year":"2015","unstructured":"Shirasaki H, Kanaizumi E, Seki N, Himi T (2015) Leukotriene E4 induces MUC5AC release from human airway epithelial NCI-H292 cells. Allergol Int 64:169\u2013174. https:\/\/doi.org\/10.1016\/j.alit.2014.11.002","journal-title":"Allergol Int"},{"key":"9098_CR100","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1165\/rcmb.2007-0293OC","volume":"39","author":"C Thompson","year":"2008","unstructured":"Thompson C, McMahon S, Boss\u00e9 Y, Dubois CM, Stankova J, Rola-Pleszczynski M (2008) Leukotriene D4 up-regulates furin expression through CysLT1 receptor signaling. Am J Respir Cell Mol Biol 39:227\u2013234. https:\/\/doi.org\/10.1165\/rcmb.2007-0293OC","journal-title":"Am J Respir Cell Mol Biol"},{"key":"9098_CR101","doi-asserted-by":"publisher","first-page":"119203","DOI":"10.1016\/j.bbamcr.2021.119203","volume":"1869","author":"K Fujimori","year":"2022","unstructured":"Fujimori K, Uno S, Kuroda K, Matsumoto C, Maehara T (2022) Leukotriene C(4) synthase is a novel PPAR\u03b3 target gene, and leukotriene C(4) and D(4) activate adipogenesis through cysteinyl LT1 receptors in adipocytes. Biochim Biophys Acta Mol Cell Res 1869:119203. https:\/\/doi.org\/10.1016\/j.bbamcr.2021.119203","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"9098_CR102","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.3390\/ph3061792","volume":"3","author":"P Montuschi","year":"2010","unstructured":"Montuschi P (2010) Role of leukotrienes and leukotriene modifiers in asthma. Pharmaceuticals (Basel) 3:1792\u20131811. https:\/\/doi.org\/10.3390\/ph3061792","journal-title":"Pharmaceuticals (Basel)"},{"key":"9098_CR103","doi-asserted-by":"publisher","first-page":"158756","DOI":"10.1016\/j.bbalip.2020.158756","volume":"1865","author":"T Hirakata","year":"2020","unstructured":"Hirakata T, Matsuda A, Yokomizo T (2020) Leukotriene B(4) receptors as therapeutic targets for ophthalmic diseases. Biochim Biophys Acta Mol Cell Biol Lipids 1865:158756. https:\/\/doi.org\/10.1016\/j.bbalip.2020.158756","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"9098_CR104","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/mi.2012.43","volume":"5","author":"A Denoyer","year":"2012","unstructured":"Denoyer A, Godefroy D, C\u00e9l\u00e9rier I, Frugier J, Riancho L, Baudouin F, Rost\u00e8ne W, Baudouin C (2012) CX3CL1 expression in the conjunctiva is involved in immune cell trafficking during toxic ocular surface inflammation. Mucosal Immunol 5:702\u2013711. https:\/\/doi.org\/10.1038\/mi.2012.43","journal-title":"Mucosal Immunol"},{"key":"9098_CR105","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1165\/rcmb.2018-0175OC","volume":"60","author":"K Pal","year":"2019","unstructured":"Pal K, Feng X, Steinke JW, Burdick MD, Shim YM, Sung SS, Teague WG, Borish L (2019) Leukotriene A4 hydrolase activation and leukotriene B4 production by eosinophils in severe asthma. Am J Respir Cell Mol Biol 60:413\u2013419. https:\/\/doi.org\/10.1165\/rcmb.2018-0175OC","journal-title":"Am J Respir Cell Mol Biol"},{"key":"9098_CR106","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1159\/000141516","volume":"82","author":"T Shibamoto","year":"2008","unstructured":"Shibamoto T, Liu W, Cui S, Zhang W, Takano H, Kurata Y (2008) PAF, rather than histamine, participates in mouse anaphylactic hypotension. Pharmacology 82:114\u2013120. https:\/\/doi.org\/10.1159\/000141516","journal-title":"Pharmacology"},{"key":"9098_CR107","doi-asserted-by":"publisher","first-page":"6327","DOI":"10.4049\/jimmunol.0904043","volume":"184","author":"KD Dyer","year":"2010","unstructured":"Dyer KD, Percopo CM, Xie Z, Yang Z, Kim JD, Davoine F, Lacy P, Druey KM, Moqbel R, Rosenberg HF (2010) Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor. J Immunol 184:6327\u20136334. https:\/\/doi.org\/10.4049\/jimmunol.0904043","journal-title":"J Immunol"},{"key":"9098_CR108","doi-asserted-by":"publisher","unstructured":"Mu\u00f1oz-Cano RM, Casas-Saucedo R, Valero Santiago A, Bobolea I, Rib\u00f3 P, Mullol J (2019) Platelet-Activating Factor (PAF) in allergic rhinitis: Clinical and therapeutic implications. J Clin Med 8. https:\/\/doi.org\/10.3390\/jcm8091338","DOI":"10.3390\/jcm8091338"},{"key":"9098_CR109","doi-asserted-by":"publisher","first-page":"4661","DOI":"10.1039\/c9fo00896a","volume":"10","author":"X Guo","year":"2019","unstructured":"Guo X, Zheng M, Pan R, Zang B, Gao J, Ma H, Jin M (2019) Hydroxysafflor yellow A (HSYA) targets the platelet-activating factor (PAF) receptor and inhibits human bronchial smooth muscle activation induced by PAF. Food Funct 10:4661\u20134673. https:\/\/doi.org\/10.1039\/c9fo00896a","journal-title":"Food Funct"},{"key":"9098_CR110","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nature13479","volume":"510","author":"CN Serhan","year":"2014","unstructured":"Serhan CN (2014) Pro-resolving lipid mediators are leads for resolution physiology. Nature 510:92\u2013101. https:\/\/doi.org\/10.1038\/nature13479","journal-title":"Nature"},{"key":"9098_CR111","doi-asserted-by":"publisher","unstructured":"Recchiuti A, Isopi E, Romano M, Mattoscio D (2020) Roles of specialized pro-resolving lipid mediators in autophagy and inflammation. Int J Mol Sci 21. https:\/\/doi.org\/10.3390\/ijms21186637","DOI":"10.3390\/ijms21186637"},{"key":"9098_CR112","doi-asserted-by":"publisher","first-page":"e60","DOI":"10.1182\/blood-2012-04-423525","volume":"120","author":"J Dalli","year":"2012","unstructured":"Dalli J, Serhan CN (2012) Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators. Blood 120:e60-72. https:\/\/doi.org\/10.1182\/blood-2012-04-423525","journal-title":"Blood"},{"key":"9098_CR113","doi-asserted-by":"publisher","first-page":"1104577","DOI":"10.3389\/fmolb.2023.1104577","volume":"10","author":"V Kumar","year":"2023","unstructured":"Kumar V, Yasmeen N, Chaudhary AA, Alawam AS, Al-Zharani M, Suliman Basher N, Harikrishnan S, Goud MD, Pandey A, Lakhawat SS, Sharma PK (2023) Specialized pro-resolving lipid mediators regulate inflammatory macrophages: A paradigm shift from antibiotics to immunotherapy for mitigating COVID-19 pandemic. Front Mol Biosci 10:1104577. https:\/\/doi.org\/10.3389\/fmolb.2023.1104577","journal-title":"Front Mol Biosci"},{"key":"9098_CR114","doi-asserted-by":"publisher","first-page":"108753","DOI":"10.1016\/j.pharmthera.2024.108753","volume":"265","author":"HY Peh","year":"2025","unstructured":"Peh HY, Chen J (2025) Pro-resolving lipid mediators and therapeutic innovations in resolution of inflammation. Pharmacol Ther 265:108753. https:\/\/doi.org\/10.1016\/j.pharmthera.2024.108753","journal-title":"Pharmacol Ther"},{"key":"9098_CR115","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1080\/14728222.2017.1364363","volume":"21","author":"LO Perucci","year":"2017","unstructured":"Perucci LO, Sugimoto MA, Gomes KB, Dusse LM, Teixeira MM, Sousa LP (2017) Annexin A1 and specialized proresolving lipid mediators: promoting resolution as a therapeutic strategy in human inflammatory diseases. Expert Opin Ther Targets 21:879\u2013896. https:\/\/doi.org\/10.1080\/14728222.2017.1364363","journal-title":"Expert Opin Ther Targets"},{"key":"9098_CR116","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1111\/j.1365-2222.2011.03852.x","volume":"41","author":"S Kanoh","year":"2011","unstructured":"Kanoh S, Tanabe T, Rubin BK (2011) IL-13-induced MUC5AC production and goblet cell differentiation is steroid resistant in human airway cells. Clin Exp Allergy 41:1747\u20131756. https:\/\/doi.org\/10.1111\/j.1365-2222.2011.03852.x","journal-title":"Clin Exp Allergy"},{"key":"9098_CR117","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1465-9921-9-27","volume":"9","author":"NK Malavia","year":"2008","unstructured":"Malavia NK, Mih JD, Raub CB, Dinh BT, George SC (2008) IL-13 induces a bronchial epithelial phenotype that is profibrotic. Respir Res 9:27. https:\/\/doi.org\/10.1186\/1465-9921-9-27","journal-title":"Respir Res"},{"key":"9098_CR118","doi-asserted-by":"publisher","first-page":"S98","DOI":"10.1513\/AnnalsATS.201711-868MG","volume":"15","author":"MA Seibold","year":"2018","unstructured":"Seibold MA (2018) Interleukin-13 stimulation reveals the cellular and functional plasticity of the airway epithelium. Ann Am Thorac Soc 15:S98-s102. https:\/\/doi.org\/10.1513\/AnnalsATS.201711-868MG","journal-title":"Ann Am Thorac Soc"},{"key":"9098_CR119","first-page":"319","volume":"26","author":"S Tete","year":"2012","unstructured":"Tete S, Saggini A, Maccauro G, Rosati M, Conti F, Cianchetti E, Tripodi D, Toniato E, Fulcheri M, Salini V et al (2012) Interleukin-9 and mast cells. J Biol Regul Homeost Agents 26:319\u2013326","journal-title":"J Biol Regul Homeost Agents"},{"key":"9098_CR120","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.mucimm.2023.05.002","volume":"16","author":"A Pajulas","year":"2023","unstructured":"Pajulas A, Fu Y, Cheung CCL, Chu M, Cannon A, Alakhras N, Zhang J, Ulrich BJ, Nelson AS, Zhou B, Kaplan MH (2023) Interleukin-9 promotes mast cell progenitor proliferation and CCR2-dependent mast cell migration in allergic airway inflammation. Mucosal Immunol 16:432\u2013445. https:\/\/doi.org\/10.1016\/j.mucimm.2023.05.002","journal-title":"Mucosal Immunol"},{"key":"9098_CR121","doi-asserted-by":"publisher","first-page":"2951","DOI":"10.1084\/jem.20130071","volume":"210","author":"JE Turner","year":"2013","unstructured":"Turner JE, Morrison PJ, Wilhelm C, Wilson M, Ahlfors H, Renauld JC, Panzer U, Helmby H, Stockinger B (2013) IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation. J Exp Med 210:2951\u20132965. https:\/\/doi.org\/10.1084\/jem.20130071","journal-title":"J Exp Med"},{"key":"9098_CR122","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00281-016-0601-1","volume":"39","author":"S Koch","year":"2017","unstructured":"Koch S, Sopel N, Finotto S (2017) Th9 and other IL-9-producing cells in allergic asthma. Semin Immunopathol 39:55\u201368. https:\/\/doi.org\/10.1007\/s00281-016-0601-1","journal-title":"Semin Immunopathol"},{"key":"9098_CR123","doi-asserted-by":"publisher","first-page":"24","DOI":"10.2340\/00015555-1191","volume":"92","author":"S Nobbe","year":"2012","unstructured":"Nobbe S, Dziunycz P, M\u00fchleisen B, Bilsborough J, Dillon SR, French LE, Hofbauer GF (2012) IL-31 expression by inflammatory cells is preferentially elevated in atopic dermatitis. Acta Derm Venereol 92:24\u201328. https:\/\/doi.org\/10.2340\/00015555-1191","journal-title":"Acta Derm Venereol"},{"key":"9098_CR124","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.jaci.2016.02.020","volume":"138","author":"M Feld","year":"2016","unstructured":"Feld M, Garcia R, Buddenkotte J, Katayama S, Lewis K, Muirhead G, Hevezi P, Plesser K, Schrumpf H, Krjutskov K et al (2016) The pruritus- and TH2-associated cytokine IL-31 promotes growth of sensory nerves. J Allergy Clin Immunol 138:500-508.e524. https:\/\/doi.org\/10.1016\/j.jaci.2016.02.020","journal-title":"J Allergy Clin Immunol"},{"key":"9098_CR125","doi-asserted-by":"publisher","first-page":"113433","DOI":"10.1016\/j.celrep.2023.113433","volume":"42","author":"S Takahashi","year":"2023","unstructured":"Takahashi S, Ochiai S, Jin J, Takahashi N, Toshima S, Ishigame H, Kabashima K, Kubo M, Nakayama M, Shiroguchi K, Okada T (2023) Sensory neuronal STAT3 is critical for IL-31 receptor expression and inflammatory itch. Cell Rep 42:113433. https:\/\/doi.org\/10.1016\/j.celrep.2023.113433","journal-title":"Cell Rep"},{"key":"9098_CR126","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.jdermsci.2014.02.009","volume":"74","author":"A Kato","year":"2014","unstructured":"Kato A, Fujii E, Watanabe T, Takashima Y, Matsushita H, Furuhashi T, Morita A (2014) Distribution of IL-31 and its receptor expressing cells in skin of atopic dermatitis. J Dermatol Sci 74:229\u2013235. https:\/\/doi.org\/10.1016\/j.jdermsci.2014.02.009","journal-title":"J Dermatol Sci"},{"key":"9098_CR127","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.jaci.2013.10.048","volume":"133","author":"F Cevikbas","year":"2014","unstructured":"Cevikbas F, Wang X, Akiyama T, Kempkes C, Savinko T, Antal A, Kukova G, Buhl T, Ikoma A, Buddenkotte J et al (2014) A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1. J Allergy Clin Immunol 133:448\u2013460. https:\/\/doi.org\/10.1016\/j.jaci.2013.10.048","journal-title":"J Allergy Clin Immunol"},{"key":"9098_CR128","doi-asserted-by":"publisher","first-page":"13510","DOI":"10.1074\/jbc.M114.622126","volume":"290","author":"R Edukulla","year":"2015","unstructured":"Edukulla R, Singh B, Jegga AG, Sontake V, Dillon SR, Madala SK (2015) Th2 cytokines augment IL-31\/IL-31RA interactions via STAT6-dependent IL-31RA expression. J Biol Chem 290:13510\u201313520. https:\/\/doi.org\/10.1074\/jbc.M114.622126","journal-title":"J Biol Chem"},{"key":"9098_CR129","doi-asserted-by":"publisher","first-page":"209","DOI":"10.4049\/jimmunol.0802712","volume":"183","author":"K Nakagome","year":"2009","unstructured":"Nakagome K, Okunishi K, Imamura M, Harada H, Matsumoto T, Tanaka R, Miyazaki J, Yamamoto K, Dohi M (2009) IFN-gamma attenuates antigen-induced overall immune response in the airway as a Th1-type immune regulatory cytokine. J Immunol 183:209\u2013220. https:\/\/doi.org\/10.4049\/jimmunol.0802712","journal-title":"J Immunol"},{"key":"9098_CR130","doi-asserted-by":"publisher","first-page":"6313","DOI":"10.4049\/jimmunol.1001454","volume":"186","author":"T Feng","year":"2011","unstructured":"Feng T, Qin H, Wang L, Benveniste EN, Elson CO, Cong Y (2011) Th17 cells induce colitis and promote Th1 cell responses through IL-17 induction of innate IL-12 and IL-23 production. J Immunol 186:6313\u20136318. https:\/\/doi.org\/10.4049\/jimmunol.1001454","journal-title":"J Immunol"},{"key":"9098_CR131","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/mi.2016.90","volume":"10","author":"A Sheih","year":"2017","unstructured":"Sheih A, Parks WC, Ziegler SF (2017) GM-CSF produced by the airway epithelium is required for sensitization to cockroach allergen. Mucosal Immunol 10:705\u2013715. https:\/\/doi.org\/10.1038\/mi.2016.90","journal-title":"Mucosal Immunol"},{"key":"9098_CR132","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1002\/pro.3519","volume":"27","author":"R Morris","year":"2018","unstructured":"Morris R, Kershaw NJ, Babon JJ (2018) The molecular details of cytokine signaling via the JAK\/STAT pathway. Protein Sci 27:1984\u20132009. https:\/\/doi.org\/10.1002\/pro.3519","journal-title":"Protein Sci"},{"key":"9098_CR133","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12964-017-0177-y","volume":"15","author":"F Seif","year":"2017","unstructured":"Seif F, Khoshmirsafa M, Aazami H, Mohsenzadegan M, Sedighi G, Bahar M (2017) The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells. Cell Commun Signal 15:23. https:\/\/doi.org\/10.1186\/s12964-017-0177-y","journal-title":"Cell Commun Signal"},{"key":"9098_CR134","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s11010-017-2963-7","volume":"430","author":"Z Shi","year":"2017","unstructured":"Shi Z, Jiang W, Wang M, Wang X, Li X, Chen X, Qiao L (2017) Inhibition of JAK\/STAT pathway restrains TSLP-activated dendritic cells mediated inflammatory T helper type 2 cell response in allergic rhinitis. Mol Cell Biochem 430:161\u2013169. https:\/\/doi.org\/10.1007\/s11010-017-2963-7","journal-title":"Mol Cell Biochem"},{"key":"9098_CR135","doi-asserted-by":"publisher","unstructured":"Liu T, Zhang L, Joo D, Sun SC (2017) NF-\u03baB signaling in inflammation. Signal Transduct Target Ther 2, 17023-. https:\/\/doi.org\/10.1038\/sigtrans.2017.23","DOI":"10.1038\/sigtrans.2017.23"},{"key":"9098_CR136","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/ni.2065","volume":"12","author":"A Oeckinghaus","year":"2011","unstructured":"Oeckinghaus A, Hayden MS, Ghosh S (2011) Crosstalk in NF-\u03baB signaling pathways. Nat Immunol 12:695\u2013708. https:\/\/doi.org\/10.1038\/ni.2065","journal-title":"Nat Immunol"},{"key":"9098_CR137","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","volume":"5","author":"H Yu","year":"2020","unstructured":"Yu H, Lin L, Zhang Z, Zhang H, Hu H (2020) Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study. Signal Transduct Target Ther 5:209. https:\/\/doi.org\/10.1038\/s41392-020-00312-6","journal-title":"Signal Transduct Target Ther"},{"key":"9098_CR138","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1002\/eji.201343496","volume":"44","author":"WF Wong","year":"2014","unstructured":"Wong WF, Looi CY, Kon S, Movahed E, Funaki T, Chang LY, Satake M, Kohu K (2014) T-cell receptor signaling induces proximal Runx1 transactivation via a calcineurin-NFAT pathway. Eur J Immunol 44:894\u2013904. https:\/\/doi.org\/10.1002\/eji.201343496","journal-title":"Eur J Immunol"},{"key":"9098_CR139","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1038\/ni.3640","volume":"18","author":"D Dutta","year":"2017","unstructured":"Dutta D, Barr VA, Akpan I, Mittelstadt PR, Singha LI, Samelson LE, Ashwell JD (2017) Recruitment of calcineurin to the TCR positively regulates T cell activation. Nat Immunol 18:196\u2013204. https:\/\/doi.org\/10.1038\/ni.3640","journal-title":"Nat Immunol"},{"key":"9098_CR140","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1515\/revneuro-2017-0060","volume":"29","author":"AM Chung","year":"2018","unstructured":"Chung AM (2018) Calcitonin gene-related peptide (CGRP): role in peripheral nerve regeneration. Rev Neurosci 29:369\u2013376. https:\/\/doi.org\/10.1515\/revneuro-2017-0060","journal-title":"Rev Neurosci"},{"key":"9098_CR141","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3389\/fendo.2017.00015","volume":"8","author":"A N'Diaye","year":"2017","unstructured":"N\u2019Diaye A, Gannesen A, Borrel V, Maillot O, Enault J, Racine PJ, Plakunov V, Chevalier S, Lesouhaitier O, Feuilloley MG (2017) Substance P and calcitonin gene-related peptide: Key regulators of cutaneous microbiota homeostasis. Front Endocrinol (Lausanne) 8:15. https:\/\/doi.org\/10.3389\/fendo.2017.00015","journal-title":"Front Endocrinol (Lausanne)"},{"key":"9098_CR142","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s10565-016-9379-0","volume":"33","author":"M Zhan","year":"2017","unstructured":"Zhan M, Zheng W, Jiang Q, Zhao Z, Wang Z, Wang J, Zhang H, He S (2017) Upregulated expression of substance P (SP) and NK1R in eczema and SP-induced mast cell accumulation. Cell Biol Toxicol 33:389\u2013405. https:\/\/doi.org\/10.1007\/s10565-016-9379-0","journal-title":"Cell Biol Toxicol"},{"key":"9098_CR143","doi-asserted-by":"publisher","first-page":"2056786","DOI":"10.1155\/2016\/2056786","volume":"2016","author":"A Gonz\u00e1lez-Hern\u00e1ndez","year":"2016","unstructured":"Gonz\u00e1lez-Hern\u00e1ndez A, Marichal-Cancino BA, Lozano-Cuenca J, L\u00f3pez-Canales JS, Mu\u00f1oz-Islas E, Ram\u00edrez-Rosas MB, Villal\u00f3n CM (2016) Heteroreceptors modulating CGRP release at neurovascular junction: Potential therapeutic implications on some vascular-related diseases. Biomed Res Int 2016:2056786. https:\/\/doi.org\/10.1155\/2016\/2056786","journal-title":"Biomed Res Int"},{"key":"9098_CR144","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1124\/jpet.102.032797","volume":"302","author":"JD Richardson","year":"2002","unstructured":"Richardson JD, Vasko MR (2002) Cellular mechanisms of neurogenic inflammation. J Pharmacol Exp Ther 302:839\u2013845. https:\/\/doi.org\/10.1124\/jpet.102.032797","journal-title":"J Pharmacol Exp Ther"},{"key":"9098_CR145","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1017\/s0967199412000111","volume":"21","author":"RN Chaves","year":"2013","unstructured":"Chaves RN, Alves AM, Lima LF, Matos HM, Rodrigues AP, Figueiredo JR (2013) Role of nerve growth factor (NGF) and its receptors in folliculogenesis. Zygote 21:187\u2013197. https:\/\/doi.org\/10.1017\/s0967199412000111","journal-title":"Zygote"},{"key":"9098_CR146","doi-asserted-by":"publisher","first-page":"182","DOI":"10.5483\/BMBRep.2011.44.3.182","volume":"44","author":"EJ Song","year":"2011","unstructured":"Song EJ, Yoo YS (2011) Nerve growth factor-induced neurite outgrowth is potentiated by stabilization of TrkA receptors. BMB Rep 44:182\u2013186. https:\/\/doi.org\/10.5483\/BMBRep.2011.44.3.182","journal-title":"BMB Rep"},{"key":"9098_CR147","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1242\/dev.085266","volume":"140","author":"L Howard","year":"2013","unstructured":"Howard L, Wyatt S, Nagappan G, Davies AM (2013) ProNGF promotes neurite growth from a subset of NGF-dependent neurons by a p75NTR-dependent mechanism. Development 140:2108\u20132117. https:\/\/doi.org\/10.1242\/dev.085266","journal-title":"Development"},{"key":"9098_CR148","doi-asserted-by":"publisher","unstructured":"Sycheva M, Sustarich J, Zhang Y, Selvaraju V, Geetha T, Gearing M, Babu JR (2019) Pro-nerve growth factor induces activation of RhoA kinase and neuronal cell death. Brain Sci 9. https:\/\/doi.org\/10.3390\/brainsci9080204","DOI":"10.3390\/brainsci9080204"},{"key":"9098_CR149","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1111\/exd.13508","volume":"27","author":"HH Andersen","year":"2018","unstructured":"Andersen HH, Lo Vecchio S, Elberling J, Yosipovitch G, Arendt-Nielsen L (2018) UVB- and NGF-induced cutaneous sensitization in humans selectively augments cowhage- and histamine-induced pain and evokes mechanical hyperknesis. Exp Dermatol 27:258\u2013267. https:\/\/doi.org\/10.1111\/exd.13508","journal-title":"Exp Dermatol"},{"key":"9098_CR150","first-page":"177","volume":"28","author":"SK Kritas","year":"2014","unstructured":"Kritas SK, Saggini A, Cerulli G, Caraffa A, Antinolfi P, Pantalone A, Frydas S, Rosati M, Tei M, Speziali A et al (2014) Neuropeptide NGF mediates neuro-immune response and inflammation through mast cell activation. J Biol Regul Homeost Agents 28:177\u2013181","journal-title":"J Biol Regul Homeost Agents"},{"key":"9098_CR151","doi-asserted-by":"publisher","first-page":"3077","DOI":"10.1021\/acschembio.6b00616","volume":"11","author":"BM Manning","year":"2016","unstructured":"Manning BM, Gruba SM, Meyer AF, Haynes CL (2016) Neuropeptide-induced mast cell degranulation and characterization of signaling modulation in response to IgE conditioning. ACS Chem Biol 11:3077\u20133083. https:\/\/doi.org\/10.1021\/acschembio.6b00616","journal-title":"ACS Chem Biol"},{"key":"9098_CR152","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1111\/jnc.13397","volume":"136","author":"HT Do","year":"2016","unstructured":"Do HT, Bruelle C, Pham DD, Jauhiainen M, Eriksson O, Korhonen LT, Lindholm D (2016) Nerve growth factor (NGF) and pro-NGF increase low-density lipoprotein (LDL) receptors in neuronal cells partly by different mechanisms: role of LDL in neurite outgrowth. J Neurochem 136:306\u2013315. https:\/\/doi.org\/10.1111\/jnc.13397","journal-title":"J Neurochem"},{"key":"9098_CR153","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1016\/j.pain.2011.07.012","volume":"152","author":"A Nitzan-Luques","year":"2011","unstructured":"Nitzan-Luques A, Devor M, Tal M (2011) Genotype-selective phenotypic switch in primary afferent neurons contributes to neuropathic pain. Pain 152:2413\u20132426. https:\/\/doi.org\/10.1016\/j.pain.2011.07.012","journal-title":"Pain"},{"key":"9098_CR154","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.neuroscience.2014.03.054","volume":"269","author":"H Wong","year":"2014","unstructured":"Wong H, Kang I, Dong XD, Christidis N, Ernberg M, Svensson P, Cairns BE (2014) NGF-induced mechanical sensitization of the masseter muscle is mediated through peripheral NMDA receptors. Neuroscience 269:232\u2013244. https:\/\/doi.org\/10.1016\/j.neuroscience.2014.03.054","journal-title":"Neuroscience"},{"key":"9098_CR155","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1016\/j.jaci.2022.01.029","volume":"149","author":"D Redhu","year":"2022","unstructured":"Redhu D, Franke K, Aparicio-Soto M, Kumari V, Pazur K, Illerhaus A, Hartmann K, Worm M, Babina M (2022) Mast cells instruct keratinocytes to produce thymic stromal lymphopoietin: Relevance of the tryptase\/protease-activated receptor 2 axis. J Allergy Clin Immunol 149:2053-2061.e2056. https:\/\/doi.org\/10.1016\/j.jaci.2022.01.029","journal-title":"J Allergy Clin Immunol"},{"key":"9098_CR156","doi-asserted-by":"publisher","first-page":"422","DOI":"10.3389\/fncel.2019.00422","volume":"13","author":"H Siiskonen","year":"2019","unstructured":"Siiskonen H, Harvima I (2019) Mast cells and sensory nerves contribute to neurogenic inflammation and pruritus in chronic skin inflammation. Front Cell Neurosci 13:422. https:\/\/doi.org\/10.3389\/fncel.2019.00422","journal-title":"Front Cell Neurosci"},{"key":"9098_CR157","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2024.12.026","author":"J Hu","year":"2025","unstructured":"Hu J, Zhao Q, Che D, Peng B, Wang X, CathyWang Z, Li L, Geng S (2025) Epidermal mechanical scratching-induced ROS exacerbates the itch-scratch cycle via TRPA1 activation on mast cells in atopic dermatitis. J Invest Dermatol. https:\/\/doi.org\/10.1016\/j.jid.2024.12.026","journal-title":"J Invest Dermatol"},{"key":"9098_CR158","doi-asserted-by":"publisher","first-page":"183330","DOI":"10.1016\/j.bbamem.2020.183330","volume":"1862","author":"J Reiche","year":"2020","unstructured":"Reiche J, Huber O (2020) Post-translational modifications of tight junction transmembrane proteins and their direct effect on barrier function. Biochim Biophys Acta Biomembr 1862:183330. https:\/\/doi.org\/10.1016\/j.bbamem.2020.183330","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"9098_CR159","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.2337\/db11-1367","volume":"61","author":"T Murakami","year":"2012","unstructured":"Murakami T, Frey T, Lin C, Antonetti DA (2012) Protein kinase c\u03b2 phosphorylates occludin regulating tight junction trafficking in vascular endothelial growth factor-induced permeability in vivo. Diabetes 61:1573\u20131583. https:\/\/doi.org\/10.2337\/db11-1367","journal-title":"Diabetes"},{"key":"9098_CR160","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1016\/j.stem.2021.04.003","volume":"28","author":"A Altshuler","year":"2021","unstructured":"Altshuler A, Amitai-Lange A, Tarazi N, Dey S, Strinkovsky L, Hadad-Porat S, Bhattacharya S, Nasser W, Imeri J, Ben-David G et al (2021) Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing. Cell Stem Cell 28:1248-1261.e1248. https:\/\/doi.org\/10.1016\/j.stem.2021.04.003","journal-title":"Cell Stem Cell"},{"key":"9098_CR161","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1080\/08820530902801478","volume":"24","author":"P Lim","year":"2009","unstructured":"Lim P, Fuchsluger TA, Jurkunas UV (2009) Limbal stem cell deficiency and corneal neovascularization. Semin Ophthalmol 24:139\u2013148. https:\/\/doi.org\/10.1080\/08820530902801478","journal-title":"Semin Ophthalmol"},{"key":"9098_CR162","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1097\/ico.0000000000002940","volume":"41","author":"N Inada","year":"2022","unstructured":"Inada N, Shoji J, Harata G, Miyazawa K, He F, Tomioka A, Hirota A, Tonozuka Y, Yamagami S (2022) Dysbiosis of ocular surface microbiota in patients with refractive allergic conjunctival diseases. Cornea 41:1232\u20131241. https:\/\/doi.org\/10.1097\/ico.0000000000002940","journal-title":"Cornea"},{"key":"9098_CR163","doi-asserted-by":"publisher","unstructured":"Song H, Xiao K, Min H, Chen Z, Long Q (2022) Characterization of conjunctival sac microbiome from patients with allergic conjunctivitis. J Clin Med 11. https:\/\/doi.org\/10.3390\/jcm11041130","DOI":"10.3390\/jcm11041130"},{"key":"9098_CR164","doi-asserted-by":"publisher","first-page":"675","DOI":"10.4103\/0971-5916.174551","volume":"142","author":"P Davoodi","year":"2015","unstructured":"Davoodi P, Mahesh PA, Holla AD, Ramachandra NB (2015) A preliminary study on the association of single nucleotide polymorphisms of interleukin 4 (IL4), IL13, IL4 receptor alpha (IL4R\u03b1) & Toll-like receptor 4 (TLR4) genes with asthma in Indian adults. Indian J Med Res 142:675\u2013680. https:\/\/doi.org\/10.4103\/0971-5916.174551","journal-title":"Indian J Med Res"},{"key":"9098_CR165","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1111\/j.1399-3038.2008.00815.x","volume":"20","author":"SE Zitnik","year":"2009","unstructured":"Zitnik SE, R\u00fcschendorf F, M\u00fcller S, Sengler C, Lee YA, Griffioen RW, Meglio P, Wahn U, Witt H, Nickel R (2009) IL13 variants are associated with total serum IgE and early sensitization to food allergens in children with atopic dermatitis. Pediatr Allergy Immunol 20:551\u2013555. https:\/\/doi.org\/10.1111\/j.1399-3038.2008.00815.x","journal-title":"Pediatr Allergy Immunol"},{"key":"9098_CR166","doi-asserted-by":"publisher","first-page":"4092","DOI":"10.1038\/s41467-020-17895-x","volume":"11","author":"ML Stevens","year":"2020","unstructured":"Stevens ML, Zhang Z, Johansson E, Ray S, Jagpal A, Ruff BP, Kothari A, He H, Martin LJ, Ji H et al (2020) Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk. Nat Commun 11:4092. https:\/\/doi.org\/10.1038\/s41467-020-17895-x","journal-title":"Nat Commun"},{"key":"9098_CR167","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.jaci.2021.05.033","volume":"149","author":"LB Murrison","year":"2022","unstructured":"Murrison LB, Ren X, Preusse K, He H, Kroner J, Chen X, Jenkins S, Johansson E, Biagini JM, Weirauch MT et al (2022) TSLP disease-associated genetic variants combined with airway TSLP expression influence asthma risk. J Allergy Clin Immunol 149:79\u201388. https:\/\/doi.org\/10.1016\/j.jaci.2021.05.033","journal-title":"J Allergy Clin Immunol"},{"key":"9098_CR168","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00251-020-01185-3","volume":"72","author":"A Laha","year":"2020","unstructured":"Laha A, Ghosh A, Moitra S, Biswas H, Saha NC, Bhattacharya S, Saha GK, Podder S (2020) Association of HLA-DQ and IL13 gene variants with challenge-proven shrimp allergy in West Bengal, India. Immunogenetics 72:489\u2013498. https:\/\/doi.org\/10.1007\/s00251-020-01185-3","journal-title":"Immunogenetics"},{"key":"9098_CR169","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.jaci.2015.11.023","volume":"138","author":"Y Yatagai","year":"2016","unstructured":"Yatagai Y, Hirota T, Sakamoto T, Yamada H, Masuko H, Kaneko Y, Iijima H, Naito T, Noguchi E, Tamari M et al (2016) Variants near the HLA complex group 22 gene (HCG22) confer increased susceptibility to late-onset asthma in Japanese populations. J Allergy Clin Immunol 138:281-283.e213. https:\/\/doi.org\/10.1016\/j.jaci.2015.11.023","journal-title":"J Allergy Clin Immunol"},{"key":"9098_CR170","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1038\/jid.2012.62","volume":"132","author":"SS Wang","year":"2012","unstructured":"Wang SS, Hon KL, Sy HY, Kong AP, Chan IH, Tse LY, Lam CW, Wong GW, Chan JC, Leung TF (2012) Interactions between genetic variants of FLG and chromosome 11q13 locus determine susceptibility for eczema phenotypes. J Invest Dermatol 132:1930\u20131932. https:\/\/doi.org\/10.1038\/jid.2012.62","journal-title":"J Invest Dermatol"},{"key":"9098_CR171","doi-asserted-by":"publisher","first-page":"7415","DOI":"10.1038\/s41467-022-35088-6","volume":"13","author":"M van Breugel","year":"2022","unstructured":"van Breugel M, Qi C, Xu Z, Pedersen CT, Petoukhov I, Vonk JM, Gehring U, Berg M, B\u00fcgel M, Carpaij OA et al (2022) Nasal DNA methylation at three CpG sites predicts childhood allergic disease. Nat Commun 13:7415. https:\/\/doi.org\/10.1038\/s41467-022-35088-6","journal-title":"Nat Commun"},{"key":"9098_CR172","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1097\/mop.0000000000000285","volume":"27","author":"A DeVries","year":"2015","unstructured":"DeVries A, Vercelli D (2015) Epigenetics in allergic diseases. Curr Opin Pediatr 27:719\u2013723. https:\/\/doi.org\/10.1097\/mop.0000000000000285","journal-title":"Curr Opin Pediatr"},{"key":"9098_CR173","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.coi.2016.05.005","volume":"42","author":"DJ Martino","year":"2016","unstructured":"Martino DJ, Saffery R, Allen KJ, Prescott SL (2016) Epigenetic modifications: mechanisms of disease and biomarkers of food allergy. Curr Opin Immunol 42:9\u201315. https:\/\/doi.org\/10.1016\/j.coi.2016.05.005","journal-title":"Curr Opin Immunol"},{"key":"9098_CR174","doi-asserted-by":"publisher","first-page":"685","DOI":"10.2217\/epi.13.68","volume":"5","author":"GA Lockett","year":"2013","unstructured":"Lockett GA, Patil VK, Soto-Ram\u00edrez N, Ziyab AH, Holloway JW, Karmaus W (2013) Epigenomics and allergic disease. Epigenomics 5:685\u2013699. https:\/\/doi.org\/10.2217\/epi.13.68","journal-title":"Epigenomics"},{"key":"9098_CR175","doi-asserted-by":"publisher","first-page":"100995","DOI":"10.1016\/j.waojou.2024.100995","volume":"17","author":"J Tu","year":"2024","unstructured":"Tu J, Wan W, Tang B, Jiang F, Wen J, Luo Q, Ye J (2024) Dissecting the pathogenic effects of smoking in blood DNA methylation on allergic diseases. World Allergy Organ J 17:100995. https:\/\/doi.org\/10.1016\/j.waojou.2024.100995","journal-title":"World Allergy Organ J"},{"key":"9098_CR176","doi-asserted-by":"publisher","first-page":"1027403","DOI":"10.3389\/fimmu.2022.1027403","volume":"13","author":"Y Wang","year":"2022","unstructured":"Wang Y, Wang H (2022) The emerging role of histone deacetylase 1 in allergic diseases. Front Immunol 13:1027403. https:\/\/doi.org\/10.3389\/fimmu.2022.1027403","journal-title":"Front Immunol"},{"key":"9098_CR177","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.it.2011.04.001","volume":"32","author":"MR Shakespear","year":"2011","unstructured":"Shakespear MR, Halili MA, Irvine KM, Fairlie DP, Sweet MJ (2011) Histone deacetylases as regulators of inflammation and immunity. Trends Immunol 32:335\u2013343. https:\/\/doi.org\/10.1016\/j.it.2011.04.001","journal-title":"Trends Immunol"},{"key":"9098_CR178","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.3389\/fimmu.2018.02414","volume":"9","author":"D Krajewski","year":"2018","unstructured":"Krajewski D, Kaczenski E, Rovatti J, Polukort S, Thompson C, Dollard C, Ser-Dolansky J, Schneider SS, Kinney SRM, Mathias CB (2018) Epigenetic regulation via altered histone acetylation results in suppression of mast cell function and mast cell-mediated food allergic responses. Front Immunol 9:2414. https:\/\/doi.org\/10.3389\/fimmu.2018.02414","journal-title":"Front Immunol"},{"key":"9098_CR179","doi-asserted-by":"publisher","first-page":"116732","DOI":"10.1016\/j.bcp.2024.116732","volume":"232","author":"YX Jiao","year":"2024","unstructured":"Jiao YX, Zhou YM, Zhou ZW, He Y, Liu S, Xu XT, Ji K, Chen JJ (2024) Histone acetylation alteration by KAT6A inhibitor WM-1119 suppresses IgE-mediated mast cell activation and allergic inflammation via reduction in AP-1 signaling. Biochem Pharmacol 232:116732. https:\/\/doi.org\/10.1016\/j.bcp.2024.116732","journal-title":"Biochem Pharmacol"},{"key":"9098_CR180","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jaci.2013.04.011","volume":"132","author":"A Rebane","year":"2013","unstructured":"Rebane A, Akdis CA (2013) MicroRNAs: Essential players in the regulation of inflammation. J Allergy Clin Immunol 132:15\u201326. https:\/\/doi.org\/10.1016\/j.jaci.2013.04.011","journal-title":"J Allergy Clin Immunol"},{"key":"9098_CR181","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s00005-019-00547-4","volume":"67","author":"K Specjalski","year":"2019","unstructured":"Specjalski K, Jassem E (2019) MicroRNAs: Potential biomarkers and targets of therapy in allergic diseases? Arch Immunol Ther Exp (Warsz) 67:213\u2013223. https:\/\/doi.org\/10.1007\/s00005-019-00547-4","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"9098_CR182","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1007\/s11882-014-0424-x","volume":"14","author":"A Rebane","year":"2014","unstructured":"Rebane A, Akdis CA (2014) MicroRNAs in allergy and asthma. Curr Allergy Asthma Rep 14:424. https:\/\/doi.org\/10.1007\/s11882-014-0424-x","journal-title":"Curr Allergy Asthma Rep"},{"key":"9098_CR183","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.coi.2015.07.006","volume":"36","author":"HH Pua","year":"2015","unstructured":"Pua HH, Ansel KM (2015) MicroRNA regulation of allergic inflammation and asthma. Curr Opin Immunol 36:101\u2013108. https:\/\/doi.org\/10.1016\/j.coi.2015.07.006","journal-title":"Curr Opin Immunol"},{"key":"9098_CR184","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/cmi.2011.19","volume":"8","author":"R Zhou","year":"2011","unstructured":"Zhou R, O\u2019Hara SP, Chen XM (2011) MicroRNA regulation of innate immune responses in epithelial cells. Cell Mol Immunol 8:371\u2013379. https:\/\/doi.org\/10.1038\/cmi.2011.19","journal-title":"Cell Mol Immunol"},{"key":"9098_CR185","doi-asserted-by":"publisher","first-page":"847168","DOI":"10.3389\/fgene.2022.847168","volume":"13","author":"NH Syed","year":"2022","unstructured":"Syed NH, Shahidan WNS, Shatriah I, Zunaina E (2022) MicroRNA profiling of the tears of children with vernal keratoconjunctivitis. Front Genet 13:847168. https:\/\/doi.org\/10.3389\/fgene.2022.847168","journal-title":"Front Genet"},{"key":"9098_CR186","doi-asserted-by":"publisher","unstructured":"Zhang H, Zhu Y, Yang C, Fu L, Huang X (2025) LncRNA FOXD3-AS1 modulates ER stress and epithelial barrier dysfunction in allergic rhinitis by destabilizing CHOP mRNA. Cell Signal 111737. https:\/\/doi.org\/10.1016\/j.cellsig.2025.111737","DOI":"10.1016\/j.cellsig.2025.111737"},{"key":"9098_CR187","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.molimm.2019.11.009","volume":"118","author":"X Zhu","year":"2020","unstructured":"Zhu X, Wang X, Wang Y, Zhao Y (2020) Exosomal long non-coding RNA GAS5 suppresses Th1 differentiation and promotes Th2 differentiation via downregulating EZH2 and T-bet in allergic rhinitis. Mol Immunol 118:30\u201339. https:\/\/doi.org\/10.1016\/j.molimm.2019.11.009","journal-title":"Mol Immunol"},{"key":"9098_CR188","doi-asserted-by":"publisher","first-page":"104215","DOI":"10.1016\/j.cellimm.2020.104215","volume":"358","author":"D Poddighe","year":"2020","unstructured":"Poddighe D, Vangelista L (2020) Effects of omalizumab on basophils: Potential biomarkers in asthma and chronic spontaneous urticaria. Cell Immunol 358:104215. https:\/\/doi.org\/10.1016\/j.cellimm.2020.104215","journal-title":"Cell Immunol"},{"key":"9098_CR189","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s40123-016-0074-2","volume":"6","author":"S Doan","year":"2017","unstructured":"Doan S, Amat F, Gabison E, Saf S, Cochereau I, Just J (2017) Omalizumab in severe refractory vernal keratoconjunctivitis in children: case series and review of the literature. Ophthalmol Ther 6:195\u2013206. https:\/\/doi.org\/10.1007\/s40123-016-0074-2","journal-title":"Ophthalmol Ther"},{"key":"9098_CR190","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/iid3.384","volume":"9","author":"S Manti","year":"2021","unstructured":"Manti S, Parisi GF, Papale M, Marseglia GL, Licari A, Leonardi S (2021) Clinical efficacy and safety of omalizumab in conventional treatment-resistant vernal keratoconjunctivitis: Our experience and literature review. Immun Inflamm Dis 9:3\u20137. https:\/\/doi.org\/10.1002\/iid3.384","journal-title":"Immun Inflamm Dis"},{"key":"9098_CR191","doi-asserted-by":"publisher","first-page":"e808","DOI":"10.1002\/iid3.808","volume":"11","author":"AS Layritz","year":"2023","unstructured":"Layritz AS, Galicia-Carre\u00f3n J, Benfadal S, Novak N (2023) Differences in allergen-specific basophil activation and T cell proliferation in atopic dermatitis patients with comorbid allergic rhinoconjunctivitis treated with a monoclonal anti-IL-4R\u03b1 antibody or allergen-specific immunotherapy. Immun Inflamm Dis 11:e808. https:\/\/doi.org\/10.1002\/iid3.808","journal-title":"Immun Inflamm Dis"},{"key":"9098_CR192","doi-asserted-by":"publisher","first-page":"3388","DOI":"10.1111\/all.15432","volume":"77","author":"E Berdyshev","year":"2022","unstructured":"Berdyshev E, Goleva E, Bissonnette R, Bronova I, Bronoff AS, Richers BN, Garcia S, Ramirez-Gama M, Taylor P, Praestgaard A et al (2022) Dupilumab significantly improves skin barrier function in patients with moderate-to-severe atopic dermatitis. Allergy 77:3388\u20133397. https:\/\/doi.org\/10.1111\/all.15432","journal-title":"Allergy"},{"key":"9098_CR193","doi-asserted-by":"publisher","first-page":"375","DOI":"10.2340\/00015555-3121","volume":"99","author":"LU Ivert","year":"2019","unstructured":"Ivert LU, Wahlgren CF, Ivert L, Lundqvist M, Bradley M (2019) Eye complications during dupilumab treatment for severe atopic dermatitis. Acta Derm Venereol 99:375\u2013378. https:\/\/doi.org\/10.2340\/00015555-3121","journal-title":"Acta Derm Venereol"},{"key":"9098_CR194","doi-asserted-by":"publisher","first-page":"e281","DOI":"10.1111\/jdv.16278","volume":"34","author":"S Gkalpakiotis","year":"2020","unstructured":"Gkalpakiotis S, Arenberger P, Skalicka P, Arenbergerova M (2020) Dupilumab therapy in a patient with atopic dermatitis and severe atopic keratoconjunctivitis. J Eur Acad Dermatol Venereol 34:e281\u2013e283. https:\/\/doi.org\/10.1111\/jdv.16278","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"9098_CR195","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.jaci.2009.11.048","volume":"125","author":"WW Busse","year":"2010","unstructured":"Busse WW, Ring J, Huss-Marp J, Kahn JE (2010) A review of treatment with mepolizumab, an anti-IL-5 mAb, in hypereosinophilic syndromes and asthma. J Allergy Clin Immunol 125:803\u2013813. https:\/\/doi.org\/10.1016\/j.jaci.2009.11.048","journal-title":"J Allergy Clin Immunol"},{"key":"9098_CR196","doi-asserted-by":"publisher","first-page":"e24","DOI":"10.2500\/aap.2025.46.240106","volume":"46","author":"S Masood","year":"2025","unstructured":"Masood S, Paracha MR, Ahmed S, Malik M, Khalid AR, Khalid MH, Fatima L, Nasir BM, Rahman SU, Khan K, Ahmad F (2025) Efficacy of anti-interleukin 5 therapy in hypereosinophilic syndrome: An updated systematic review and meta-analysis. Allergy Asthma Proc 46:e24\u2013e32. https:\/\/doi.org\/10.2500\/aap.2025.46.240106","journal-title":"Allergy Asthma Proc"},{"key":"9098_CR197","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1016\/j.jaci.2013.02.042","volume":"131","author":"IM Otani","year":"2013","unstructured":"Otani IM, Anilkumar AA, Newbury RO, Bhagat M, Beppu LY, Dohil R, Broide DH, Aceves SS (2013) Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis. J Allergy Clin Immunol 131:1576\u20131582. https:\/\/doi.org\/10.1016\/j.jaci.2013.02.042","journal-title":"J Allergy Clin Immunol"},{"key":"9098_CR198","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.anl.2018.07.011","volume":"46","author":"Y Iino","year":"2019","unstructured":"Iino Y, Takahashi E, Ida S, Kikuchi S (2019) Clinical efficacy of anti-IL-5 monoclonal antibody mepolizumab in the treatment of eosinophilic otitis media. Auris Nasus Larynx 46:196\u2013203. https:\/\/doi.org\/10.1016\/j.anl.2018.07.011","journal-title":"Auris Nasus Larynx"},{"key":"9098_CR199","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1517\/13543784.2012.690029","volume":"21","author":"K Vaddi","year":"2012","unstructured":"Vaddi K, Luchi M (2012) JAK inhibition for the treatment of rheumatoid arthritis: a new era in oral DMARD therapy. Expert Opin Investig Drugs 21:961\u2013973. https:\/\/doi.org\/10.1517\/13543784.2012.690029","journal-title":"Expert Opin Investig Drugs"},{"key":"9098_CR200","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1021\/acs.jmedchem.2c01977","volume":"66","author":"G Thoma","year":"2023","unstructured":"Thoma G, Duthaler RO, Waelchli R, Hauchard A, Bruno S, Strittmatter-Keller U, Orjuela Leon A, Viebrock S, Aichholz R, Beltz K et al (2023) Discovery and characterization of the topical soft JAK inhibitor CEE321 for atopic dermatitis. J Med Chem 66:2161\u20132168. https:\/\/doi.org\/10.1021\/acs.jmedchem.2c01977","journal-title":"J Med Chem"},{"key":"9098_CR201","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.jaci.2021.08.009","volume":"148","author":"R Chovatiya","year":"2021","unstructured":"Chovatiya R, Paller AS (2021) JAK inhibitors in the treatment of atopic dermatitis. J Allergy Clin Immunol 148:927\u2013940. https:\/\/doi.org\/10.1016\/j.jaci.2021.08.009","journal-title":"J Allergy Clin Immunol"},{"key":"9098_CR202","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1111\/jdv.15489","volume":"33","author":"K Phan","year":"2019","unstructured":"Phan K, Sebaratnam DF (2019) JAK inhibitors for alopecia areata: a systematic review and meta-analysis. J Eur Acad Dermatol Venereol 33:850\u2013856. https:\/\/doi.org\/10.1111\/jdv.15489","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"9098_CR203","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/j.jaip.2024.04.034","volume":"12","author":"PS Creticos","year":"2024","unstructured":"Creticos PS, Gunaydin FE, Nolte H, Damask C, Durham SR (2024) Allergen immunotherapy: The evidence supporting the efficacy and safety of subcutaneous immunotherapy and sublingual forms of immunotherapy for allergic rhinitis\/conjunctivitis and asthma. J Allergy Clin Immunol Pract 12:1415\u20131427. https:\/\/doi.org\/10.1016\/j.jaip.2024.04.034","journal-title":"J Allergy Clin Immunol Pract"},{"key":"9098_CR204","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1002\/lary.24295","volume":"124","author":"N Erekosima","year":"2014","unstructured":"Erekosima N, Suarez-Cuervo C, Ramanathan M, Kim JM, Chelladurai Y, Segal JB, Lin SY (2014) Effectiveness of subcutaneous immunotherapy for allergic rhinoconjunctivitis and asthma: a systematic review. Laryngoscope 124:616\u2013627. https:\/\/doi.org\/10.1002\/lary.24295","journal-title":"Laryngoscope"},{"key":"9098_CR205","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1002\/alr.22149","volume":"8","author":"J Yang","year":"2018","unstructured":"Yang J, Zhang L, Zhao Z, Liao S (2018) Sublingual immunotherapy for pediatric allergic conjunctivitis: a meta-analysis of randomized controlled trials. Int Forum Allergy Rhinol 8:1253\u20131259. https:\/\/doi.org\/10.1002\/alr.22149","journal-title":"Int Forum Allergy Rhinol"},{"key":"9098_CR206","doi-asserted-by":"publisher","unstructured":"Calderon MA, Penagos M, Sheikh A, Canonica GW, Durham S (2011) Sublingual immunotherapy for treating allergic conjunctivitis. Cochrane Database Syst Rev, Cd007685. https:\/\/doi.org\/10.1002\/14651858.CD007685.pub2","DOI":"10.1002\/14651858.CD007685.pub2"},{"key":"9098_CR207","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.jaci.2013.10.041","volume":"133","author":"PS Creticos","year":"2014","unstructured":"Creticos PS, Esch RE, Couroux P, Gentile D, D\u2019Angelo P, Whitlow B, Alexander M, Coyne TC (2014) Randomized, double-blind, placebo-controlled trial of standardized ragweed sublingual-liquid immunotherapy for allergic rhinoconjunctivitis. J Allergy Clin Immunol 133:751\u2013758. https:\/\/doi.org\/10.1016\/j.jaci.2013.10.041","journal-title":"J Allergy Clin Immunol"},{"key":"9098_CR208","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.jaci.2012.06.047","volume":"130","author":"U Wahn","year":"2012","unstructured":"Wahn U, Klimek L, Ploszczuk A, Adelt T, Sandner B, Trebas-Pietras E, Eberle P, Bufe A (2012) High-dose sublingual immunotherapy with single-dose aqueous grass pollen extract in children is effective and safe: a double-blind, placebo-controlled study. J Allergy Clin Immunol 130:886-893.e885. https:\/\/doi.org\/10.1016\/j.jaci.2012.06.047","journal-title":"J Allergy Clin Immunol"},{"key":"9098_CR209","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1002\/lary.23935","volume":"123","author":"DH Wang","year":"2013","unstructured":"Wang DH, Chen L, Cheng L, Li KN, Yuan H, Lu JH, Li H (2013) Fast onset of action of sublingual immunotherapy in house dust mite-induced allergic rhinitis: a multicenter, randomized, double-blind, placebo-controlled trial. Laryngoscope 123:1334\u20131340. https:\/\/doi.org\/10.1002\/lary.23935","journal-title":"Laryngoscope"},{"key":"9098_CR210","doi-asserted-by":"publisher","first-page":"42","DOI":"10.2500\/ajra.2017.31.4447","volume":"31","author":"Y Guo","year":"2017","unstructured":"Guo Y, Li Y, Wang D, Liu Q, Liu Z, Hu L (2017) A randomized, double-blind, placebo controlled trial of sublingual immunotherapy with house-dust mite extract for allergic rhinitis. Am J Rhinol Allergy 31:42\u201347. https:\/\/doi.org\/10.2500\/ajra.2017.31.4447","journal-title":"Am J Rhinol Allergy"},{"key":"9098_CR211","doi-asserted-by":"publisher","unstructured":"Garrido-Fern\u00e1ndez S, Fern\u00e1ndez DG, L\u00f3pez GS, Mar Escribano Rodr\u00edguez MD, Delgado VM, Iglesias-Souto J, Castro G\u00f3mez C, B\u00f2ria EV, Hern\u00e1ndez-Pe\u00f1a J, S\u00e1nchez-L\u00f3pez J (2024) Satisfaction, Qol and adherence of patients allergic to dust mites and\/or pollens undergoing sublingual immunotherapy. Immunotherapy 16:693\u2013704. https:\/\/doi.org\/10.1080\/1750743x.2024.2347828","DOI":"10.1080\/1750743x.2024.2347828"},{"key":"9098_CR212","doi-asserted-by":"publisher","first-page":"272","DOI":"10.2500\/aap.2022.43.220036","volume":"43","author":"L DuBuske","year":"2022","unstructured":"DuBuske L (2022) Efficacy and safety of sublingual allergen immunotherapy. Allergy Asthma Proc 43:272\u2013280. https:\/\/doi.org\/10.2500\/aap.2022.43.220036","journal-title":"Allergy Asthma Proc"},{"key":"9098_CR213","doi-asserted-by":"publisher","first-page":"100985","DOI":"10.1016\/j.waojou.2024.100985","volume":"17","author":"D Di Bona","year":"2024","unstructured":"Di Bona D, Paoletti G, Ordak M, Dragonieri S, Cognet-Sice J, Scurati S, Canonica GW (2024) A 300 IR 5-grass pollen sublingual immunotherapy tablet-specific systematic review and meta-analysis confirms its clinical benefits for patients with allergic rhinoconjunctivitis with or without asthma. World Allergy Organ J 17:100985. https:\/\/doi.org\/10.1016\/j.waojou.2024.100985","journal-title":"World Allergy Organ J"}],"container-title":["Clinical Reviews in Allergy & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-025-09098-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12016-025-09098-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-025-09098-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T05:16:01Z","timestamp":1756444561000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12016-025-09098-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,29]]},"references-count":213,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["9098"],"URL":"https:\/\/doi.org\/10.1007\/s12016-025-09098-3","relation":{},"ISSN":["1559-0267"],"issn-type":[{"value":"1559-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,29]]},"assertion":[{"value":"21 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"85"}}