{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:58:45Z","timestamp":1788026325909,"version":"build-2784847793"},"reference-count":143,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clinic Rev Allerg Immunol"],"DOI":"10.1007\/s12016-026-09168-0","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T02:26:14Z","timestamp":1778120774000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["\u03b3\u03b4 T Cell-Mediated Neuroimmune Interactions in Skin Inflammation and Allergy"],"prefix":"10.1007","volume":"69","author":[{"given":"Shixiong","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2355-4869","authenticated-orcid":false,"given":"Tetsuya","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"9168_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.619954","volume":"11","author":"Y Li","year":"2020","unstructured":"Li Y, Li G, Zhang J, Wu X, Chen X (2020) The dual roles of human \u03b3\u03b4 T Cells: anti-tumor or tumor-promoting. Front Immunol 11:619954. https:\/\/doi.org\/10.3389\/fimmu.2020.619954","journal-title":"Front Immunol"},{"key":"9168_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9081757","author":"F Morandi","year":"2020","unstructured":"Morandi F, Yazdanifar M, Cocco C, Bertaina A, Airoldi I (2020) Engineering the bridge between innate and adaptive immunity for cancer immunotherapy: focus on \u03b3\u03b4 T and NK Cells. Cells. https:\/\/doi.org\/10.3390\/cells9081757","journal-title":"Cells"},{"key":"9168_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051206","author":"Y Liu","year":"2020","unstructured":"Liu Y, Zhang C (2020) The role of human \u03b3\u03b4 T Cells in anti-tumor immunity and their potential for cancer immunotherapy. Cells. https:\/\/doi.org\/10.3390\/cells9051206","journal-title":"Cells"},{"key":"9168_CR4","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1038\/s43018-024-00798-x","volume":"5","author":"M Arias-Badia","year":"2024","unstructured":"Arias-Badia M, Chang R, Fong L (2024) \u03b3\u03b4 T cells as critical anti-tumor immune effectors. Nat Cancer 5:1145\u20131157. https:\/\/doi.org\/10.1038\/s43018-024-00798-x","journal-title":"Nat Cancer"},{"key":"9168_CR5","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1093\/jleuko\/qiad103","volume":"115","author":"TK Suen","year":"2024","unstructured":"Suen TK et al (2024) BCG vaccination induces innate immune memory in \u03b3\u03b4 T cells in humans. J Leukoc Biol 115:149\u2013163. https:\/\/doi.org\/10.1093\/jleuko\/qiad103","journal-title":"J Leukoc Biol"},{"key":"9168_CR6","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/bs.ircmb.2025.08.010","volume":"398","author":"I Espeleta","year":"2025","unstructured":"Espeleta I, Gorgon RA, S\u00e1nchez-Madrid F, Cibrian D (2025) Deciphering the role of \u03b3\u03b4 T cells in skin inflammatory diseases: insights from psoriasis, atopic dermatitis, and alopecia areata. Int Rev Cell Mol Biol 398:75\u201398. https:\/\/doi.org\/10.1016\/bs.ircmb.2025.08.010","journal-title":"Int Rev Cell Mol Biol"},{"key":"9168_CR7","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1084\/jem.20012000","volume":"195","author":"M Girardi","year":"2002","unstructured":"Girardi M et al (2002) Resident skin-specific gammadelta T cells provide local, nonredundant regulation of cutaneous inflammation. J Exp Med 195:855\u2013867. https:\/\/doi.org\/10.1084\/jem.20012000","journal-title":"J Exp Med"},{"key":"9168_CR8","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.mucimm.2024.12.012","volume":"18","author":"J Karjalainen","year":"2025","unstructured":"Karjalainen J, Hain S, Progatzky F (2025) Glial-immune interactions in barrier organs. Mucosal Immunol 18:271\u2013278. https:\/\/doi.org\/10.1016\/j.mucimm.2024.12.012","journal-title":"Mucosal Immunol"},{"key":"9168_CR9","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/j.jaci.2023.03.013","volume":"151","author":"AW Liu","year":"2023","unstructured":"Liu AW, Gillis JE, Sumpter TL, Kaplan DH (2023) Neuroimmune interactions in atopic and allergic contact dermatitis. J Allergy Clin Immunol 151:1169\u20131177. https:\/\/doi.org\/10.1016\/j.jaci.2023.03.013","journal-title":"J Allergy Clin Immunol"},{"key":"9168_CR10","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.cell.2016.04.041","volume":"165","author":"H Veiga-Fernandes","year":"2016","unstructured":"Veiga-Fernandes H, Mucida D (2016) Neuro-immune interactions at barrier surfaces. Cell 165:801\u2013811. https:\/\/doi.org\/10.1016\/j.cell.2016.04.041","journal-title":"Cell"},{"key":"9168_CR11","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1126\/science.adv5974","volume":"391","author":"J Tian","year":"2026","unstructured":"Tian J et al (2026) A sympathetic-eosinophil axis orchestrates psychological stress to exacerbate skin inflammation. Sci (New York N Y) 391:1269\u20131277. https:\/\/doi.org\/10.1126\/science.adv5974","journal-title":"Sci (New York N Y)"},{"key":"9168_CR12","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aea7017","volume":"12","author":"L Huang","year":"2026","unstructured":"Huang L et al (2026) Sympathetic nerve aggravates autoimmune skin disease via NE-adrenergic receptor axis: Neuroimmune cross-talk insights from vitiligo. Science advances 12:eaea7017. https:\/\/doi.org\/10.1126\/sciadv.aea7017","journal-title":"Science advances"},{"key":"9168_CR13","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/nature13199","volume":"510","author":"L Riol-Blanco","year":"2014","unstructured":"Riol-Blanco L et al (2014) Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation. Nature 510:157\u2013161. https:\/\/doi.org\/10.1038\/nature13199","journal-title":"Nature"},{"key":"9168_CR14","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/s41586-024-07869-0","volume":"634","author":"CH Flayer","year":"2024","unstructured":"Flayer CH et al (2024) A \u03b3\u03b4 T cell-IL-3 axis controls allergic responses through sensory neurons. Nature 634:440\u2013446. https:\/\/doi.org\/10.1038\/s41586-024-07869-0","journal-title":"Nature"},{"key":"9168_CR15","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/319420a0","volume":"319","author":"MP Lefranc","year":"1986","unstructured":"Lefranc MP, Forster A, Rabbitts TH (1986) Rearrangement of two distinct T-cell gamma-chain variable-region genes in human DNA. Nature 319:420\u2013422. https:\/\/doi.org\/10.1038\/319420a0","journal-title":"Nature"},{"key":"9168_CR16","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1146\/annurev.immunol.14.1.511","volume":"14","author":"YH Chien","year":"1996","unstructured":"Chien YH, Jores R, Crowley MP (1996) Recognition by gamma\/delta T cells. Annu Rev Immunol 14:511\u2013532. https:\/\/doi.org\/10.1146\/annurev.immunol.14.1.511","journal-title":"Annu Rev Immunol"},{"key":"9168_CR17","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201949006","volume":"21","author":"AC Dolens","year":"2020","unstructured":"Dolens AC et al (2020) Distinct Notch1 and BCL11B requirements mediate human \u03b3\u03b4\/\u03b1\u03b2 T cell development. EMBO Rep 21:e49006. https:\/\/doi.org\/10.15252\/embr.201949006","journal-title":"EMBO Rep"},{"key":"9168_CR18","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1038\/s41590-020-0747-9","volume":"21","author":"J Roels","year":"2020","unstructured":"Roels J et al (2020) Distinct and temporary-restricted epigenetic mechanisms regulate human \u03b1\u03b2 and \u03b3\u03b4 T cell development. Nat Immunol 21:1280\u20131292. https:\/\/doi.org\/10.1038\/s41590-020-0747-9","journal-title":"Nat Immunol"},{"key":"9168_CR19","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.immuni.2012.06.003","volume":"37","author":"JD Haas","year":"2012","unstructured":"Haas JD et al (2012) Development of interleukin-17-producing \u03b3\u03b4 T cells is restricted to a functional embryonic wave. Immunity 37:48\u201359. https:\/\/doi.org\/10.1016\/j.immuni.2012.06.003","journal-title":"Immunity"},{"key":"9168_CR20","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1002\/eji.201343759","volume":"43","author":"I Prinz","year":"2013","unstructured":"Prinz I, Silva-Santos B, Pennington DJ (2013) Functional development of \u03b3\u03b4 T cells. Eur J Immunol 43:1988\u20131994. https:\/\/doi.org\/10.1002\/eji.201343759","journal-title":"Eur J Immunol"},{"key":"9168_CR21","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adn2093","volume":"10","author":"RGR Pinheiro","year":"2025","unstructured":"Pinheiro RGR, Silva-Santos B (2025) Reaching maturity: thymic \u03b3\u03b4 T cell differentiation in mice and humans. Sci Immunol 10:eadn2093. https:\/\/doi.org\/10.1126\/sciimmunol.adn2093","journal-title":"Sci Immunol"},{"key":"9168_CR22","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.immuni.2008.04.022","volume":"29","author":"KD Jensen","year":"2008","unstructured":"Jensen KD et al (2008) Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity 29:90\u2013100. https:\/\/doi.org\/10.1016\/j.immuni.2008.04.022","journal-title":"Immunity"},{"key":"9168_CR23","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1600-065X.2010.00947.x","volume":"238","author":"T Kreslavsky","year":"2010","unstructured":"Kreslavsky T, Gleimer M, Garbe AI, von Boehmer H (2010) \u03b1\u03b2 versus \u03b3\u03b4 fate choice: counting the T-cell lineages at the branch point. Immunol Rev 238:169\u2013181. https:\/\/doi.org\/10.1111\/j.1600-065X.2010.00947.x","journal-title":"Immunol Rev"},{"key":"9168_CR24","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/s41568-019-0153-5","volume":"19","author":"B Silva-Santos","year":"2019","unstructured":"Silva-Santos B, Mensurado S, Coffelt SB (2019) \u03b3\u03b4 T cells: pleiotropic immune effectors with therapeutic potential in cancer. Nat Rev Cancer 19:392\u2013404. https:\/\/doi.org\/10.1038\/s41568-019-0153-5","journal-title":"Nat Rev Cancer"},{"key":"9168_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2026.107167","volume":"280","author":"I Lorga","year":"2026","unstructured":"Lorga I, L\u00e9on-Lara X, Ravens S (2026) Functional spectrum of \u03b3\u03b4 T cells in perinatal infectious diseases. Immunol Lett 280:107167. https:\/\/doi.org\/10.1016\/j.imlet.2026.107167","journal-title":"Immunol Lett"},{"key":"9168_CR26","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nri3384","volume":"13","author":"P Vantourout","year":"2013","unstructured":"Vantourout P, Hayday A (2013) Six-of-the-best: unique contributions of \u03b3\u03b4 T cells to immunology. Nat Rev Immunol 13:88\u2013100. https:\/\/doi.org\/10.1038\/nri3384","journal-title":"Nat Rev Immunol"},{"key":"9168_CR27","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1038\/s41423-021-00656-1","volume":"18","author":"Y Hu","year":"2021","unstructured":"Hu Y et al (2021) Single-cell analysis reveals the origins and intrahepatic development of liver-resident IFN-\u03b3-producing \u03b3\u03b4 T cells. Cell Mol Immunol 18:954\u2013968. https:\/\/doi.org\/10.1038\/s41423-021-00656-1","journal-title":"Cell Mol Immunol"},{"key":"9168_CR28","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s00018-020-03613-9","volume":"78","author":"Y Xu","year":"2021","unstructured":"Xu Y, Dimitrion P, Cvetkovski S, Zhou L, Mi QS (2021) Epidermal resident \u03b3\u03b4 T cell development and function in skin. Cell Mol Life Sci 78:573\u2013580. https:\/\/doi.org\/10.1007\/s00018-020-03613-9","journal-title":"Cell Mol Life Sci"},{"key":"9168_CR29","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1038\/322836a0","volume":"322","author":"JS Heilig","year":"1986","unstructured":"Heilig JS, Tonegawa S (1986) Diversity of murine gamma genes and expression in fetal and adult T lymphocytes. Nature 322:836\u2013840. https:\/\/doi.org\/10.1038\/322836a0","journal-title":"Nature"},{"key":"9168_CR30","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1615\/CritRevImmunol.2022047288","volume":"42","author":"W Zhang","year":"2022","unstructured":"Zhang W, Pajulas A, Kaplan MH (2022) \u03b3\u03b4 T cells in skin inflammation. Crit Rev Immunol 42:43\u201356. https:\/\/doi.org\/10.1615\/CritRevImmunol.2022047288","journal-title":"Crit Rev Immunol"},{"key":"9168_CR31","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-004579","author":"E Bruni","year":"2022","unstructured":"Bruni E et al (2022) Intrahepatic CD69(+)V\u03b41 T cells re-circulate in the blood of patients with metastatic colorectal cancer and limit tumor progression. J Immunother Cancer. https:\/\/doi.org\/10.1136\/jitc-2022-004579","journal-title":"J Immunother Cancer"},{"key":"9168_CR32","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/imr.12915","volume":"298","author":"MA Fischer","year":"2020","unstructured":"Fischer MA, Golovchenko NB, Edelblum KL (2020) \u03b3\u03b4 T cell migration: separating trafficking from surveillance behaviors at barrier surfaces. Immunol Rev 298:165\u2013180. https:\/\/doi.org\/10.1111\/imr.12915","journal-title":"Immunol Rev"},{"key":"9168_CR33","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/s41590-021-01124-8","volume":"23","author":"DR McKenzie","year":"2022","unstructured":"McKenzie DR et al (2022) Normality sensing licenses local T cells for innate-like tissue surveillance. Nat Immunol 23:411\u2013422. https:\/\/doi.org\/10.1038\/s41590-021-01124-8","journal-title":"Nat Immunol"},{"key":"9168_CR34","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.immuni.2023.01.025","volume":"56","author":"M Frascoli","year":"2023","unstructured":"Frascoli M et al (2023) Skin \u03b3\u03b4 T cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol. Immunity 56:562-575.e566. https:\/\/doi.org\/10.1016\/j.immuni.2023.01.025","journal-title":"Immunity"},{"issue":"1","key":"9168_CR35","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1182\/blood-2011-01-331298","volume":"118","author":"N Caccamo","year":"2011","unstructured":"Caccamo N et al (2011) Differentiation, phenotype, and function of interleukin-17-producing human V\u03b39V\u03b42 T cells. Blood 118(1):129\u2013138. https:\/\/doi.org\/10.1182\/blood-2011-01-331298","journal-title":"Blood"},{"key":"9168_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.660361","volume":"12","author":"A Madhok","year":"2021","unstructured":"Madhok A et al (2021) Transcriptome signature of V\u03b39V\u03b42 T cells treated with phosphoantigens and Notch inhibitor reveals interplay between TCR and Notch signaling pathways. Front Immunol 12:660361. https:\/\/doi.org\/10.3389\/fimmu.2021.660361","journal-title":"Front Immunol"},{"key":"9168_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16162852","author":"AB Jones","year":"2024","unstructured":"Jones AB et al (2024) Temozolomide and the PARP inhibitor Niraparib enhance expression of Natural Killer group 2D ligand ULBP1 and gamma-delta T Cell cytotoxicity in Glioblastoma. Cancers. https:\/\/doi.org\/10.3390\/cancers16162852","journal-title":"Cancers"},{"key":"9168_CR38","doi-asserted-by":"publisher","DOI":"10.1080\/2162402x.2022.2030021","volume":"11","author":"R Serrano","year":"2022","unstructured":"Serrano R et al (2022) Stimulatory and inhibitory activity of STING ligands on tumor-reactive human gamma\/delta T cells. Oncoimmunology 11:2030021. https:\/\/doi.org\/10.1080\/2162402x.2022.2030021","journal-title":"Oncoimmunology"},{"key":"9168_CR39","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202404432","volume":"12","author":"J Luo","year":"2025","unstructured":"Luo J et al (2025) \u03b3\u03b4 T cell-mediated tumor immunity is tightly regulated by STING and TGF-\u03b2 signaling pathways. Advanced Science 12:e2404432. https:\/\/doi.org\/10.1002\/advs.202404432","journal-title":"Advanced Science"},{"key":"9168_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2022.104391","volume":"131","author":"A Matsuyama-Kato","year":"2022","unstructured":"Matsuyama-Kato A et al (2022) Differential activation of chicken gamma delta T cells from different tissues by Toll-like receptor 3 or 21 ligands. Developmental and comparative immunology 131:104391. https:\/\/doi.org\/10.1016\/j.dci.2022.104391","journal-title":"Developmental and comparative immunology"},{"key":"9168_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molimm.2025.02.019","volume":"181","author":"S Uzun\u00e7ay\u0131r","year":"2025","unstructured":"Uzun\u00e7ay\u0131r S et al (2025) The superantigen SEA binds to human \u03b3\u03b4 T cell receptor and activates \u03b3\u03b4 T cells with moderate MHC class II dependence. Molecular immunology 181:1\u20138. https:\/\/doi.org\/10.1016\/j.molimm.2025.02.019","journal-title":"Molecular immunology"},{"issue":"5","key":"9168_CR42","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.4049\/jimmunol.2100967","volume":"208","author":"D Sun","year":"2022","unstructured":"Sun D, Chan N, Shao H, Born WK, Kaplan HJ (2022) \u03b3\u03b4 T Cells activated in different inflammatory environments are functionally distinct. J Immunol 208(5):1224\u20131231. https:\/\/doi.org\/10.4049\/jimmunol.2100967","journal-title":"J Immunol"},{"key":"9168_CR43","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1016\/j.cell.2024.02.006","volume":"187","author":"L Qi","year":"2024","unstructured":"Qi L et al (2024) A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes. Cell 187:1508-1526e.e1516. https:\/\/doi.org\/10.1016\/j.cell.2024.02.006","journal-title":"Cell"},{"key":"9168_CR44","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1093\/bjd\/ljac066","volume":"188","author":"M Talagas","year":"2023","unstructured":"Talagas M (2023) Anatomical contacts between sensory neurons and epidermal cells: an unrecognized anatomical network for neuro-immuno-cutaneous crosstalk. Br J Dermatol 188:176\u2013185. https:\/\/doi.org\/10.1093\/bjd\/ljac066","journal-title":"Br J Dermatol"},{"key":"9168_CR45","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.neuron.2013.07.051","volume":"79","author":"VE Abraira","year":"2013","unstructured":"Abraira VE, Ginty DD (2013) The sensory neurons of touch. Neuron 79:618\u2013639. https:\/\/doi.org\/10.1016\/j.neuron.2013.07.051","journal-title":"Neuron"},{"key":"9168_CR46","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nature13980","volume":"516","author":"SS Ranade","year":"2014","unstructured":"Ranade SS et al (2014) Piezo2 is the major transducer of mechanical forces for touch sensation in mice. Nature 516:121\u2013125. https:\/\/doi.org\/10.1038\/nature13980","journal-title":"Nature"},{"key":"9168_CR47","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","volume":"139","author":"AI Basbaum","year":"2009","unstructured":"Basbaum AI, Bautista DM, Scherrer G, Julius D (2009) Cellular and molecular mechanisms of pain. Cell 139:267\u2013284. https:\/\/doi.org\/10.1016\/j.cell.2009.09.028","journal-title":"Cell"},{"key":"9168_CR48","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nn.3881","volume":"18","author":"D Usoskin","year":"2015","unstructured":"Usoskin D et al (2015) Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing. Nat Neurosci 18:145\u2013153. https:\/\/doi.org\/10.1038\/nn.3881","journal-title":"Nat Neurosci"},{"key":"9168_CR49","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.627985","volume":"8","author":"A Ruppenstein","year":"2021","unstructured":"Ruppenstein A et al (2021) Involvement of neuro-immune interactions in pruritus with special focus on receptor expressions. Front Med 8:627985. https:\/\/doi.org\/10.3389\/fmed.2021.627985","journal-title":"Front Med"},{"key":"9168_CR50","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/s0092-8674(01)00483-4","volume":"106","author":"X Dong","year":"2001","unstructured":"Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (2001) A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell 106:619\u2013632. https:\/\/doi.org\/10.1016\/s0092-8674(01)00483-4","journal-title":"Cell"},{"key":"9168_CR51","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1126\/science.1233765","volume":"340","author":"SK Mishra","year":"2013","unstructured":"Mishra SK, Hoon MA (2013) The cells and circuitry for itch responses in mice. Science (New York, N.Y.) 340:968\u2013971. https:\/\/doi.org\/10.1126\/science.1233765","journal-title":"Science (New York, N.Y.)"},{"issue":"4","key":"9168_CR52","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s10565-016-9379-0","volume":"33","author":"M Zhan","year":"2017","unstructured":"Zhan M et al (2017) Upregulated expression of substance P (SP) and NK1R in eczema and SP-induced mast cell accumulation. Cell Biol Toxicol 33(4):389\u2013405. https:\/\/doi.org\/10.1007\/s10565-016-9379-0","journal-title":"Cell Biol Toxicol"},{"key":"9168_CR53","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1038\/nn896","volume":"5","author":"H Olausson","year":"2002","unstructured":"Olausson H et al (2002) Unmyelinated tactile afferents signal touch and project to insular cortex. Nat Neurosci 5:900\u2013904. https:\/\/doi.org\/10.1038\/nn896","journal-title":"Nat Neurosci"},{"key":"9168_CR54","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/nature11810","volume":"493","author":"S Vrontou","year":"2013","unstructured":"Vrontou S, Wong AM, Rau KK, Koerber HR, Anderson DJ (2013) Genetic identification of C fibres that detect massage-like stroking of hairy skin in vivo. Nature 493:669\u2013673. https:\/\/doi.org\/10.1038\/nature11810","journal-title":"Nature"},{"key":"9168_CR55","doi-asserted-by":"publisher","DOI":"10.1111\/exd.15029","volume":"33","author":"M Shastri","year":"2024","unstructured":"Shastri M et al (2024) Cutaneous-immuno-neuro-endocrine (CINE) system: a complex enterprise transforming skin into a super organ. Experimental dermatology 33:e15029. https:\/\/doi.org\/10.1111\/exd.15029","journal-title":"Experimental dermatology"},{"key":"9168_CR56","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2019.102004","volume":"79","author":"AK Sandoval-Talamantes","year":"2020","unstructured":"Sandoval-Talamantes AK et al (2020) Neurotransmitters, neuropeptides and their receptors interact with immune response in healthy and psoriatic skin. Neuropeptides 79:102004. https:\/\/doi.org\/10.1016\/j.npep.2019.102004","journal-title":"Neuropeptides"},{"key":"9168_CR57","doi-asserted-by":"publisher","first-page":"18","DOI":"10.18502\/ijaai.v19i1.2414","volume":"19","author":"J Fadaee","year":"2020","unstructured":"Fadaee J et al (2020) Evaluation of serum Substance P level in chronic urticaria and correlation with disease severity. Iranian journal of allergy, asthma, and immunology 19:18\u201326. https:\/\/doi.org\/10.18502\/ijaai.v19i1.2414","journal-title":"Iranian journal of allergy, asthma, and immunology"},{"key":"9168_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2020.101344","volume":"64","author":"K Atsumi","year":"2020","unstructured":"Atsumi K et al (2020) Sensory neurons in the human jugular ganglion. Tissue & cell 64:101344. https:\/\/doi.org\/10.1016\/j.tice.2020.101344","journal-title":"Tissue & cell"},{"key":"9168_CR59","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1111\/exd.14173","volume":"29","author":"A Stegemann","year":"2020","unstructured":"Stegemann A, B\u00f6hm M (2020) Targeting the \u03b17 nicotinic acetylcholine receptor-a novel road towards the future treatment of skin diseases. Exp Dermatol 29:924\u2013931. https:\/\/doi.org\/10.1111\/exd.14173","journal-title":"Exp Dermatol"},{"key":"9168_CR60","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2322574121","volume":"121","author":"W Kulalert","year":"2024","unstructured":"Kulalert W et al (2024) The neuroimmune CGRP-RAMP1 axis tunes cutaneous adaptive immunity to the microbiota. Proceedings of the National Academy of Sciences of the United States of America 121:e2322574121. https:\/\/doi.org\/10.1073\/pnas.2322574121","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"9168_CR61","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02052-25","volume":"16","author":"S Rahmdel","year":"2025","unstructured":"Rahmdel S, Luqman A, G\u00f6tz F (2025) Microbiota-derived aromatic amino acid decarboxylases: linking microbial fitness and host neurochemical communication. mBio 16:e0205225. https:\/\/doi.org\/10.1128\/mbio.02052-25","journal-title":"mBio"},{"key":"9168_CR62","doi-asserted-by":"publisher","first-page":"573679","DOI":"10.3389\/fmicb.2020.573679","volume":"11","author":"A Luqman","year":"2020","unstructured":"Luqman A et al (2020) The Neuromodulator-Encoding sadA Gene Is Widely Distributed in the Human Skin Microbiome. Front Microbiol 11:573679. https:\/\/doi.org\/10.3389\/fmicb.2020.573679","journal-title":"Front Microbiol"},{"key":"9168_CR63","doi-asserted-by":"publisher","DOI":"10.1111\/exd.15181","volume":"33","author":"HQ Qu","year":"2024","unstructured":"Qu HQ, Kao C, Hakonarson H (2024) Implications of the non-neuronal cholinergic system for therapeutic interventions of inflammatory skin diseases. Exp Dermatol 33:e15181. https:\/\/doi.org\/10.1111\/exd.15181","journal-title":"Exp Dermatol"},{"key":"9168_CR64","doi-asserted-by":"publisher","DOI":"10.3390\/ph16020246","author":"X Huang","year":"2023","unstructured":"Huang X, Li F, Wang F (2023) Neural regulation of innate immunity in inflammatory skin diseases. Pharmaceuticals (Basel, Switzerland). https:\/\/doi.org\/10.3390\/ph16020246","journal-title":"Pharmaceuticals (Basel, Switzerland)"},{"key":"9168_CR65","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.tins.2023.05.003","volume":"46","author":"V Feuillet","year":"2023","unstructured":"Feuillet V, Ugolini S, Reynders A (2023) Differential regulation of cutaneous immunity by sensory neuron subsets. Trends Neurosci 46:640\u2013653. https:\/\/doi.org\/10.1016\/j.tins.2023.05.003","journal-title":"Trends Neurosci"},{"key":"9168_CR66","doi-asserted-by":"publisher","DOI":"10.1097\/pr9.0000000000001220","volume":"10","author":"C Sommer","year":"2025","unstructured":"Sommer C, \u00dc\u00e7eyler N (2025) Small fiber pathology in fibromyalgia syndrome. Pain Rep 10:e1220. https:\/\/doi.org\/10.1097\/pr9.0000000000001220","journal-title":"Pain Rep"},{"key":"9168_CR67","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13030663","author":"E Yang","year":"2025","unstructured":"Yang E et al (2025) Deciphering pain and pruritus in keloids from the perspective of neurological dysfunction: Where are we now? Biomedicines. https:\/\/doi.org\/10.3390\/biomedicines13030663","journal-title":"Biomedicines"},{"key":"9168_CR68","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1038\/s41577-025-01199-6","volume":"25","author":"A Leunig","year":"2025","unstructured":"Leunig A, Gianeselli M, Russo SJ, Swirski FK (2025) Connection and communication between the nervous and immune systems. Nat Rev Immunol 25:912\u2013933. https:\/\/doi.org\/10.1038\/s41577-025-01199-6","journal-title":"Nat Rev Immunol"},{"key":"9168_CR69","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.jaci.2024.03.006","volume":"154","author":"NC Wilcox","year":"2024","unstructured":"Wilcox NC et al (2024) Interactions between skin-resident dendritic and Langerhans cells and pain-sensing neurons. J Allergy Clin Immunol 154:11\u201319. https:\/\/doi.org\/10.1016\/j.jaci.2024.03.006","journal-title":"J Allergy Clin Immunol"},{"key":"9168_CR70","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1093\/intimm\/dxx040","volume":"29","author":"T Voisin","year":"2017","unstructured":"Voisin T, Bouvier A, Chiu IM (2017) Neuro-immune interactions in allergic diseases: novel targets for therapeutics. Int Immunol 29:247\u2013261. https:\/\/doi.org\/10.1093\/intimm\/dxx040","journal-title":"Int Immunol"},{"key":"9168_CR71","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2021.100361","volume":"18","author":"YJ Kim","year":"2021","unstructured":"Kim YJ, Granstein RD (2021) Roles of Calcitonin gene-related peptide in the skin, and other physiological and pathophysiological functions. Brain Behav Immun Health 18:100361. https:\/\/doi.org\/10.1016\/j.bbih.2021.100361","journal-title":"Brain Behav Immun Health"},{"key":"9168_CR72","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/s41586-025-09921-z","volume":"651","author":"W Zhang","year":"2026","unstructured":"Zhang W et al (2026) Neuro-epithelial circuits promote sensory convergence and intestinal immunity. Nature 651:440\u2013450. https:\/\/doi.org\/10.1038\/s41586-025-09921-z","journal-title":"Nature"},{"key":"9168_CR73","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/nm.4501","volume":"24","author":"P Baral","year":"2018","unstructured":"Baral P et al (2018) Nociceptor sensory neurons suppress neutrophil and \u03b3\u03b4 T cell responses in bacterial lung infections and lethal pneumonia. Nat Med 24:417\u2013426. https:\/\/doi.org\/10.1038\/nm.4501","journal-title":"Nat Med"},{"key":"9168_CR74","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.regpep.2013.03.020","volume":"184","author":"Y Zhou","year":"2013","unstructured":"Zhou Y et al (2013) Calcitonin gene-related peptide promotes the wound healing of human bronchial epithelial cells via PKC and MAPK pathways. Regul Pept 184:22\u201329. https:\/\/doi.org\/10.1016\/j.regpep.2013.03.020","journal-title":"Regul Pept"},{"key":"9168_CR75","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.neuron.2019.01.012","volume":"101","author":"DP Green","year":"2019","unstructured":"Green DP, Limjunyawong N, Gour N, Pundir P, Dong X (2019) A mast-cell-specific receptor mediates neurogenic inflammation and pain. Neuron 101:412-420.e413. https:\/\/doi.org\/10.1016\/j.neuron.2019.01.012","journal-title":"Neuron"},{"key":"9168_CR76","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1645095","volume":"16","author":"D Li","year":"2025","unstructured":"Li D et al (2025) Mast cell-neuron axis as a core mechanism in chronic pruritus of atopic dermatitis: from mechanistic insights to therapeutic targets. Front Immunol 16:1645095. https:\/\/doi.org\/10.3389\/fimmu.2025.1645095","journal-title":"Front Immunol"},{"key":"9168_CR77","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.immuni.2020.10.001","volume":"53","author":"C Perner","year":"2020","unstructured":"Perner C et al (2020) Substance P release by sensory neurons triggers dendritic cell migration and initiates the type-2 immune response to allergens. Immunity 53:1063-1077e.e1067. https:\/\/doi.org\/10.1016\/j.immuni.2020.10.001","journal-title":"Immunity"},{"key":"9168_CR78","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/s41586-021-03563-7","volume":"594","author":"G Hoeffel","year":"2021","unstructured":"Hoeffel G et al (2021) Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions. Nature 594:94\u201399. https:\/\/doi.org\/10.1038\/s41586-021-03563-7","journal-title":"Nature"},{"key":"9168_CR79","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s12272-020-01280-9","volume":"44","author":"D Dorotea","year":"2021","unstructured":"Dorotea D, Ha H (2021) Activation of \u03b2(2) adrenergic receptor signaling modulates inflammation: a target limiting the progression of kidney diseases. Arch Pharm Res 44:49\u201362. https:\/\/doi.org\/10.1007\/s12272-020-01280-9","journal-title":"Arch Pharm Res"},{"key":"9168_CR80","doi-asserted-by":"publisher","first-page":"449","DOI":"10.2174\/1567201814666170201150015","volume":"14","author":"K Duris","year":"2017","unstructured":"Duris K, Lipkova J, Jurajda M (2017) Cholinergic anti-inflammatory pathway and stroke. Curr Drug Deliv 14:449\u2013457. https:\/\/doi.org\/10.2174\/1567201814666170201150015","journal-title":"Curr Drug Deliv"},{"key":"9168_CR81","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nature01339","volume":"421","author":"H Wang","year":"2003","unstructured":"Wang H et al (2003) Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 421:384\u2013388. https:\/\/doi.org\/10.1038\/nature01339","journal-title":"Nature"},{"key":"9168_CR82","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2025.111470","volume":"229","author":"J Liu","year":"2025","unstructured":"Liu J, Chen Y, Chen G (2025) The role and mechanisms of macrophages in chronic pain: a peripheral-to-central perspective. Brain Res Bull 229:111470. https:\/\/doi.org\/10.1016\/j.brainresbull.2025.111470","journal-title":"Brain Res Bull"},{"key":"9168_CR83","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1007\/s00586-023-07672-x","volume":"32","author":"J Ma","year":"2023","unstructured":"Ma J et al (2023) Celecoxib alleviates nociceptor sensitization mediated by interleukin-1beta-primed annulus fibrosus cells. Eur Spine J 32:2048\u20132058. https:\/\/doi.org\/10.1007\/s00586-023-07672-x","journal-title":"Eur Spine J"},{"key":"9168_CR84","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.jaci.2023.05.004","volume":"152","author":"L Misery","year":"2023","unstructured":"Misery L et al (2023) Basic mechanisms of itch. J Allergy Clin Immunol 152:11\u201323. https:\/\/doi.org\/10.1016\/j.jaci.2023.05.004","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"9168_CR85","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.cell.2022.12.037","volume":"186","author":"M Enamorado","year":"2023","unstructured":"Enamorado M et al (2023) Immunity to the microbiota promotes sensory neuron regeneration. Cell 186(3):607-620.e17. https:\/\/doi.org\/10.1016\/j.cell.2022.12.037","journal-title":"Cell"},{"key":"9168_CR86","doi-asserted-by":"publisher","unstructured":"Almaguer B, Jameson J (2022) Examining the relationship between epidermal gamma delta T cells and neuropeptide Y. J Immunol 208(Supplement_1): 53\u201322. https:\/\/doi.org\/10.4049\/jimmunol.208.supp.53.22","DOI":"10.4049\/jimmunol.208.supp.53.22"},{"key":"9168_CR87","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1158\/2767-9764.crc-23-0570","volume":"4","author":"FL Baker","year":"2024","unstructured":"Baker FL et al (2024) Exercise-induced \u03b22-adrenergic Receptor activation enhances the antileukemic activity of expanded \u03b3\u03b4 T-Cells via DNAM-1 upregulation and PVR\/Nectin-2 recognition. Cancer Res Commun 4:1253\u20131267. https:\/\/doi.org\/10.1158\/2767-9764.crc-23-0570","journal-title":"Cancer Res Commun"},{"key":"9168_CR88","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03082","volume":"10","author":"FL Baker","year":"2019","unstructured":"Baker FL et al (2019) Systemic \u03b2-Adrenergic Receptor activation augments the ex vivo expansion and anti-tumor activity of V\u03b39V\u03b42 T-Cells. Front Immunol 10:3082. https:\/\/doi.org\/10.3389\/fimmu.2019.03082","journal-title":"Front Immunol"},{"key":"9168_CR89","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113721","volume":"43","author":"T Liu","year":"2024","unstructured":"Liu T et al (2024) An axon-T cell feedback loop enhances inflammation and axon degeneration. Cell Rep 43:113721. https:\/\/doi.org\/10.1016\/j.celrep.2024.113721","journal-title":"Cell Rep"},{"key":"9168_CR90","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50970-1","volume":"15","author":"Y Zhang","year":"2024","unstructured":"Zhang Y et al (2024) High-sensitive sensory neurons exacerbate rosacea-like dermatitis in mice by activating \u03b3\u03b4 T cells directly. Nat Commun 15:7265. https:\/\/doi.org\/10.1038\/s41467-024-50970-1","journal-title":"Nat Commun"},{"key":"9168_CR91","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.molimm.2021.10.020","volume":"141","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Ma X, Zha Z, Zhao Z, Li J (2022) The protective effects of allopurinol against IL-17A-induced inflammatory response in mast cells. Mol Immunol 141:53\u201359. https:\/\/doi.org\/10.1016\/j.molimm.2021.10.020","journal-title":"Mol Immunol"},{"key":"9168_CR92","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1007\/s12016-024-08991-7","volume":"66","author":"I Sieminska","year":"2024","unstructured":"Sieminska I, Pieniawska M, Grzywa TM (2024) The immunology of psoriasis-current concepts in pathogenesis. Clin Rev Allergy Immunol 66:164\u2013191. https:\/\/doi.org\/10.1007\/s12016-024-08991-7","journal-title":"Clin Rev Allergy Immunol"},{"key":"9168_CR93","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.66.2.10","volume":"66","author":"Y Li","year":"2025","unstructured":"Li Y et al (2025) IL-23 promotes \u03b3\u03b4T cell activity in dry eye disease progression. Invest Ophthalmol Vis Sci 66:10. https:\/\/doi.org\/10.1167\/iovs.66.2.10","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"9168_CR94","doi-asserted-by":"publisher","unstructured":"Rizk J et al (2023) The cIAP ubiquitin ligases sustain type 3 \u03b3\u03b4 T cells and ILC during aging to promote barrier immunity. J Exp Med 220. https:\/\/doi.org\/10.1084\/jem.20221534","DOI":"10.1084\/jem.20221534"},{"key":"9168_CR95","doi-asserted-by":"publisher","first-page":"885","DOI":"10.3389\/fimmu.2018.00885","volume":"9","author":"A Reinhardt","year":"2018","unstructured":"Reinhardt A, Prinz I (2018) Whodunit? The contribution of interleukin (IL)-17\/IL-22-producing \u03b3\u03b4 T cells, \u03b1\u03b2 T cells, and innate lymphoid cells to the pathogenesis of spondyloarthritis. Front Immunol 9:885. https:\/\/doi.org\/10.3389\/fimmu.2018.00885","journal-title":"Front Immunol"},{"key":"9168_CR96","doi-asserted-by":"publisher","first-page":"4637","DOI":"10.1073\/pnas.1813562116","volume":"116","author":"TT Ta","year":"2019","unstructured":"Ta TT et al (2019) Priming of microglia with IFN-\u03b3 slows neuronal gamma oscillations in situ. Proc Natl Acad Sci U S A 116:4637\u20134642. https:\/\/doi.org\/10.1073\/pnas.1813562116","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9168_CR97","doi-asserted-by":"publisher","first-page":"204","DOI":"10.2174\/1570159x21666230811142713","volume":"22","author":"SJ Gao","year":"2024","unstructured":"Gao SJ et al (2024) Interleukin-17: A putative novel pharmacological target for pathological pain. Curr Neuropharmacol 22:204\u2013216. https:\/\/doi.org\/10.2174\/1570159x21666230811142713","journal-title":"Curr Neuropharmacol"},{"key":"9168_CR98","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/nature08900","volume":"464","author":"DR Neill","year":"2010","unstructured":"Neill DR et al (2010) Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464:1367\u20131370. https:\/\/doi.org\/10.1038\/nature08900","journal-title":"Nature"},{"key":"9168_CR99","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.cytogfr.2023.09.002","volume":"74","author":"RK Srivastava","year":"2023","unstructured":"Srivastava RK et al (2023) Unravelling the immunobiology of innate lymphoid cells (ILCs): implications in health and disease. Cytokine Growth Factor Rev 74:56\u201375. https:\/\/doi.org\/10.1016\/j.cytogfr.2023.09.002","journal-title":"Cytokine Growth Factor Rev"},{"key":"9168_CR100","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007069","volume":"14","author":"F Sparber","year":"2018","unstructured":"Sparber F et al (2018) Langerin\u2009+\u2009DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection. PLoS Pathog 14:e1007069. https:\/\/doi.org\/10.1371\/journal.ppat.1007069","journal-title":"PLoS Pathog"},{"key":"9168_CR101","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/nature23469","volume":"549","author":"V Cardoso","year":"2017","unstructured":"Cardoso V et al (2017) Neuronal regulation of type 2 innate lymphoid cells via neuromedin U. Nature 549:277\u2013281. https:\/\/doi.org\/10.1038\/nature23469","journal-title":"Nature"},{"key":"9168_CR102","doi-asserted-by":"publisher","first-page":"486","DOI":"10.4168\/aair.2025.17.4.486","volume":"17","author":"X Qi","year":"2025","unstructured":"Qi X et al (2025) Neuromedin U activation of group 2 innate lymphocytes exacerbates local inflammation of nasal mucosa in allergic rhinitis. Allergy Asthma Immunol Res 17:486\u2013504. https:\/\/doi.org\/10.4168\/aair.2025.17.4.486","journal-title":"Allergy Asthma Immunol Res"},{"key":"9168_CR103","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/s41586-020-2039-9","volume":"579","author":"J Talbot","year":"2020","unstructured":"Talbot J et al (2020) Feeding-dependent VIP neuron-ILC3 circuit regulates the intestinal barrier. Nature 579:575\u2013580. https:\/\/doi.org\/10.1038\/s41586-020-2039-9","journal-title":"Nature"},{"key":"9168_CR104","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/nature18644","volume":"535","author":"S Ibiza","year":"2016","unstructured":"Ibiza S et al (2016) Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence. Nature 535:440\u2013443. https:\/\/doi.org\/10.1038\/nature18644","journal-title":"Nature"},{"key":"9168_CR105","doi-asserted-by":"publisher","unstructured":"Lam K, Colin J, Almaguer B, Tulloch P, Jameson J (2025) Skin Resident T Cell Interactions with NPY1R(+) Neurons During Wound Repair Are Impaired by Obesity. bioRxiv: the preprint server for biology. https:\/\/doi.org\/10.1101\/2025.06.06.658336","DOI":"10.1101\/2025.06.06.658336"},{"key":"9168_CR106","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1111\/imr.12183","volume":"260","author":"JP McAleer","year":"2014","unstructured":"McAleer JP, Kolls JK (2014) Directing traffic: IL-17 and IL-22 coordinate pulmonary immune defense. Immunol Rev 260:129\u2013144. https:\/\/doi.org\/10.1111\/imr.12183","journal-title":"Immunol Rev"},{"key":"9168_CR107","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1034\/j.1600-0897.2002.01131.x","volume":"48","author":"O Nagaeva","year":"2002","unstructured":"Nagaeva O, Jonsson L, Mincheva-Nilsson L (2002) Dominant IL-10 and TGF-beta mRNA expression in gammadeltaT cells of human early pregnancy decidua suggests immunoregulatory potential. American journal of reproductive immunology (New York, N.Y.\u202f: 1989) 48:9\u201317. https:\/\/doi.org\/10.1034\/j.1600-0897.2002.01131.x","journal-title":"American journal of reproductive immunology (New York, N.Y. : 1989)"},{"key":"9168_CR108","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.3892\/etm.2017.5638","volume":"15","author":"Y Zhang","year":"2018","unstructured":"Zhang Y et al (2018) IL-25 promotes Th2 bias by upregulating IL-4 and IL-10 expression of decidual \u03b3\u03b4T cells in early pregnancy. Experimental therapeutic Med 15:1855\u20131862. https:\/\/doi.org\/10.3892\/etm.2017.5638","journal-title":"Experimental therapeutic Med"},{"key":"9168_CR109","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s00005-019-00545-6","volume":"67","author":"LS Santos","year":"2019","unstructured":"Santos LS et al (2019) IgG from non-atopic individuals induces in vitro IFN-\u03b3 and IL-10 production by human intra-thymic \u03b3\u03b4T cells: a comparison with atopic IgG and IVIg. Arch Immunol Ther Exp Warsz 67:263\u2013270. https:\/\/doi.org\/10.1007\/s00005-019-00545-6","journal-title":"Arch Immunol Ther Exp Warsz"},{"key":"9168_CR110","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112283","volume":"144","author":"S Wang","year":"2021","unstructured":"Wang S et al (2021) REV-ERB agonist suppresses IL-17 production in \u03b3\u03b4T cells and improves psoriatic dermatitis in a mouse model. Biomed Pharmacother 144:112283. https:\/\/doi.org\/10.1016\/j.biopha.2021.112283","journal-title":"Biomed Pharmacother"},{"key":"9168_CR111","doi-asserted-by":"publisher","unstructured":"Yang Z et al (2025) Nervonic acid mitigates IMQ-triggered psoriasis in mice via inhibiting Th17\/\u03b3\u03b4T17 cell invasion and modulating the gut microbiota. J Leukoc Biol 117. https:\/\/doi.org\/10.1093\/jleuko\/qiaf070","DOI":"10.1093\/jleuko\/qiaf070"},{"key":"9168_CR112","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1080\/15548627.2020.1725381","volume":"17","author":"Z Wang","year":"2021","unstructured":"Wang Z et al (2021) Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation. Autophagy 17:529\u2013552. https:\/\/doi.org\/10.1080\/15548627.2020.1725381","journal-title":"Autophagy"},{"key":"9168_CR113","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1111\/1346-8138.12367","volume":"41","author":"A Ueyama","year":"2014","unstructured":"Ueyama A et al (2014) Mechanism of pathogenesis of imiquimod-induced skin inflammation in the mouse: a role for interferon-alpha in dendritic cell activation by imiquimod. J Dermatol 41:135\u2013143. https:\/\/doi.org\/10.1111\/1346-8138.12367","journal-title":"J Dermatol"},{"key":"9168_CR114","doi-asserted-by":"publisher","first-page":"3034","DOI":"10.1016\/j.celrep.2019.05.019","volume":"27","author":"Y Cai","year":"2019","unstructured":"Cai Y et al (2019) Differential roles of the mTOR-STAT3 signaling in dermal \u03b3\u03b4 T cell effector function in skin inflammation. Cell Rep 27:3034-3048e.e3035. https:\/\/doi.org\/10.1016\/j.celrep.2019.05.019","journal-title":"Cell Rep"},{"key":"9168_CR115","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02828","volume":"10","author":"X Chen","year":"2019","unstructured":"Chen X, Morrissey S, Chen F, Yan J (2019) Novel insight into the molecular and metabolic mechanisms orchestrating IL-17 production in \u03b3\u03b4 T cells. Front Immunol 10:2828. https:\/\/doi.org\/10.3389\/fimmu.2019.02828","journal-title":"Front Immunol"},{"key":"9168_CR116","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-026-12601-5","author":"MJ Akagha","year":"2026","unstructured":"Akagha MJ et al (2026) IFN\u03b3 shapes macrophage inflammatory responses by STAT1 isoform-specific epigenetic and transcriptional mechanisms. BMC Genomics. https:\/\/doi.org\/10.1186\/s12864-026-12601-5","journal-title":"BMC Genomics"},{"key":"9168_CR117","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1111\/j.1365-2222.2007.02826.x","volume":"37","author":"S Korematsu","year":"2007","unstructured":"Korematsu S, Tanaka Y, Nagakura T, Minato N, Izumi T (2007) Human gammadelta T cells modulate the mite allergen-specific T-helper type 2-skewed immunity. Clin Exp Allergy 37:1681\u20131687. https:\/\/doi.org\/10.1111\/j.1365-2222.2007.02826.x","journal-title":"Clin Exp Allergy"},{"key":"9168_CR118","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.867167","volume":"13","author":"K Kolbe","year":"2022","unstructured":"Kolbe K et al (2022) Inversed ratio of CD39\/CD73 expression on \u03b3\u03b4 T cells in HIV versus healthy controls correlates with immune activation and disease progression. Front Immunol 13:867167. https:\/\/doi.org\/10.3389\/fimmu.2022.867167","journal-title":"Front Immunol"},{"key":"9168_CR119","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/j.1600-065X.2008.00706.x","volume":"226","author":"DM Mosser","year":"2008","unstructured":"Mosser DM, Zhang X (2008) Interleukin-10: new perspectives on an old cytokine. Immunol Rev 226:205\u2013218. https:\/\/doi.org\/10.1111\/j.1600-065X.2008.00706.x","journal-title":"Immunol Rev"},{"key":"9168_CR120","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/cmi.2015.07","volume":"13","author":"Y Mao","year":"2016","unstructured":"Mao Y et al (2016) A new effect of IL-4 on human \u03b3\u03b4 T cells: promoting regulatory V\u03b41 T cells via IL-10 production and inhibiting function of V\u03b42 T cells. Cell Mol Immunol 13:217\u2013228. https:\/\/doi.org\/10.1038\/cmi.2015.07","journal-title":"Cell Mol Immunol"},{"key":"9168_CR121","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1097\/01.bcr.0000440705.91099.cc","volume":"35","author":"M Rani","year":"2014","unstructured":"Rani M, Zhang Q, Schwacha MG (2014) Burn wound \u03b3\u03b4 T-cells support a Th2 and Th17 immune response. J Burn Care Res 35:46\u201353. https:\/\/doi.org\/10.1097\/01.bcr.0000440705.91099.cc","journal-title":"J Burn Care Res"},{"key":"9168_CR122","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-026-03817-z","author":"I Thomas","year":"2026","unstructured":"Thomas I et al (2026) Nociceptor neurons shape antiviral immunity. J Neuroinflammation. https:\/\/doi.org\/10.1186\/s12974-026-03817-z","journal-title":"J Neuroinflammation"},{"key":"9168_CR123","doi-asserted-by":"publisher","first-page":"3640","DOI":"10.1182\/blood-2006-09-046128","volume":"109","author":"S Nakae","year":"2007","unstructured":"Nakae S, Suto H, Berry GJ, Galli SJ (2007) Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice. Blood 109:3640\u20133648. https:\/\/doi.org\/10.1182\/blood-2006-09-046128","journal-title":"Blood"},{"key":"9168_CR124","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.580304","volume":"11","author":"J Wo","year":"2020","unstructured":"Wo J et al (2020) The role of gamma-delta T Cells in diseases of the Central Nervous System. Front Immunol 11:580304. https:\/\/doi.org\/10.3389\/fimmu.2020.580304","journal-title":"Front Immunol"},{"key":"9168_CR125","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.621956","volume":"12","author":"H Bugaut","year":"2021","unstructured":"Bugaut H, Aractingi S (2021) Major role of the IL17\/23 axis in Psoriasis supports the development of new targeted therapies. Front Immunol 12:621956. https:\/\/doi.org\/10.3389\/fimmu.2021.621956","journal-title":"Front Immunol"},{"key":"9168_CR126","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.jpain.2010.08.003","volume":"12","author":"CF Kim","year":"2011","unstructured":"Kim CF, Moalem-Taylor G (2011) Interleukin-17 contributes to neuroinflammation and neuropathic pain following peripheral nerve injury in mice. J Pain 12:370\u2013383. https:\/\/doi.org\/10.1016\/j.jpain.2010.08.003","journal-title":"J Pain"},{"issue":"1","key":"9168_CR127","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s11658-025-00834-3","volume":"31","author":"Z Li","year":"2026","unstructured":"Li Z et al (2026) The neuro-immune insights of itch: peripheral mechanisms and central glial contributions. Cell Mol Biol Lett 31:18. https:\/\/doi.org\/10.1186\/s11658-025-00834-3","journal-title":"Cell Mol Biol Lett"},{"key":"9168_CR128","doi-asserted-by":"publisher","first-page":"175.102","DOI":"10.4049\/jimmunol.210.Supp.175.02","volume":"210","author":"B Almaguer","year":"2023","unstructured":"Almaguer B, Tulloch P, La Prairie C, Jameson JM (2023) Examining the relationship between gamma delta T cells and sensory peripheral nerves in the skin. J Immunol 210:175.102-175.102. https:\/\/doi.org\/10.4049\/jimmunol.210.Supp.175.02","journal-title":"J Immunol"},{"key":"9168_CR129","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmeth.2022.100350","volume":"2","author":"ED Yu","year":"2022","unstructured":"Yu ED et al (2022) Ex vivo assays show human gamma-delta T cells specific for common allergens are Th1-polarized in allergic donors. Cell Rep Methods 2:100350. https:\/\/doi.org\/10.1016\/j.crmeth.2022.100350","journal-title":"Cell Rep Methods"},{"key":"9168_CR130","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2012.00200","volume":"3","author":"MD de Oliveira Henriques","year":"2012","unstructured":"de Oliveira Henriques MD, Penido C (2012) \u03b3\u03b4 T Lymphocytes coordinate eosinophil influx during allergic responses. Front Pharmacol 3:200. https:\/\/doi.org\/10.3389\/fphar.2012.00200","journal-title":"Front Pharmacol"},{"key":"9168_CR131","doi-asserted-by":"publisher","first-page":"L104","DOI":"10.1152\/ajplung.00090.2023","volume":"325","author":"M Makullah","year":"2023","unstructured":"Makullah M, Ellis DA, Jones M, Steele C (2023) Hematopoietic 12\/15-lipoxygenase activity negatively contributes to fungal-associated allergic asthma. Am J Physiol Lung Cell Mol Physiol 325:L104\u2013l113. https:\/\/doi.org\/10.1152\/ajplung.00090.2023","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"9168_CR132","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.70292","volume":"24","author":"JST Hooks","year":"2025","unstructured":"Hooks JST et al (2025) Innate and adaptive immune responses to clinical hyaluronic acid fillers. J Cosmet Dermatol 24:e70292. https:\/\/doi.org\/10.1111\/jocd.70292","journal-title":"J Cosmet Dermatol"},{"key":"9168_CR133","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.101988","author":"JC Wang","year":"2026","unstructured":"Wang JC et al (2026) Nociceptor neurons control pollution-mediated neutrophilic asthma. eLife. https:\/\/doi.org\/10.7554\/eLife.101988","journal-title":"eLife"},{"key":"9168_CR134","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1007\/s12016-023-08966-0","volume":"65","author":"UH Hsu","year":"2023","unstructured":"Hsu UH, Chiang BL (2023) \u03b3\u03b4 T cells and allergic diseases. Clin Rev Allergy Immunol 65:172\u2013182. https:\/\/doi.org\/10.1007\/s12016-023-08966-0","journal-title":"Clin Rev Allergy Immunol"},{"key":"9168_CR135","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.jaci.2021.04.012","volume":"148","author":"MC Berin","year":"2021","unstructured":"Berin MC et al (2021) Acute FPIES reactions are associated with an IL-17 inflammatory signature. J Allergy Clin Immunol 148:895-901.e896. https:\/\/doi.org\/10.1016\/j.jaci.2021.04.012","journal-title":"J Allergy Clin Immunol"},{"key":"9168_CR136","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1007\/s11357-022-00515-5","volume":"44","author":"P Singh","year":"2022","unstructured":"Singh P, Szaraz-Szeles M, Mezei Z, Barath S, Hevessy Z (2022) Age-dependent frequency of unconventional T cells in a healthy adult Caucasian population: a combinational study of invariant natural killer T cells, \u03b3\u03b4 T cells, and mucosa-associated invariant T cells. GeroScience 44:2047\u20132060. https:\/\/doi.org\/10.1007\/s11357-022-00515-5","journal-title":"GeroScience"},{"key":"9168_CR137","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1002\/jlb.5a1121-583rr","volume":"112","author":"P Singh","year":"2022","unstructured":"Singh P, Szaraz-Szeles M, Mezei Z, Barath S, Hevessy Z (2022) Gender-dependent frequency of unconventional T cells in a healthy adult Caucasian population: a combinational study of invariant NKT cells, \u03b3\u03b4 T cells, and mucosa-associated invariant T cells. J Leukoc Biol 112:1155\u20131165. https:\/\/doi.org\/10.1002\/jlb.5a1121-583rr","journal-title":"J Leukoc Biol"},{"key":"9168_CR138","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1183\/09031936.00094306","volume":"29","author":"T Kallinich","year":"2007","unstructured":"Kallinich T, Beier KC, Wahn U, Stock P, Hamelmann E (2007) T-cell co-stimulatory molecules: their role in allergic immune reactions. Eur Respir J 29:1246\u20131255. https:\/\/doi.org\/10.1183\/09031936.00094306","journal-title":"Eur Respir J"},{"key":"9168_CR139","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1542191","volume":"16","author":"X Yu","year":"2025","unstructured":"Yu X et al (2025) Neutrophils negatively control IL-17A-producing \u03b3\u03b4 T cell frequencies in a contact-dependent manner under physiological conditions. Front Immunol 16:1542191. https:\/\/doi.org\/10.3389\/fimmu.2025.1542191","journal-title":"Front Immunol"},{"key":"9168_CR140","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1007\/s00011-023-01704-4","volume":"72","author":"L Qiu","year":"2023","unstructured":"Qiu L, Zhang Y, Zeng X (2023) The function of \u03b3\u03b4 T cells in humoral immune responses. Inflamm Res 72:747\u2013755. https:\/\/doi.org\/10.1007\/s00011-023-01704-4","journal-title":"Inflamm Res"},{"key":"9168_CR141","doi-asserted-by":"publisher","first-page":"829","DOI":"10.2147\/ccid.s462797","volume":"17","author":"L Potestio","year":"2024","unstructured":"Potestio L et al (2024) The role of Interleukin 23\/17 axis in psoriasis management: a comprehensive review of clinical trials. Clin Cosmet Investig Dermatol 17:829\u2013842. https:\/\/doi.org\/10.2147\/ccid.s462797","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"9168_CR142","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1111\/bjd.13814","volume":"173","author":"D Tha\u00e7i","year":"2015","unstructured":"Tha\u00e7i D et al (2015) Secukinumab in psoriasis: randomized, controlled phase 3 trial results assessing the potential to improve treatment response in partial responders (STATURE). Br J Dermatol 173:777\u2013787. https:\/\/doi.org\/10.1111\/bjd.13814","journal-title":"Br J Dermatol"},{"key":"9168_CR143","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.scib.2021.11.013","volume":"67","author":"Z Li","year":"2022","unstructured":"Li Z et al (2022) Single-cell RNA-seq and chromatin accessibility profiling decipher the heterogeneity of mouse \u03b3\u03b4 T cells. Sci Bull 67:408\u2013426. https:\/\/doi.org\/10.1016\/j.scib.2021.11.013","journal-title":"Sci Bull"}],"container-title":["Clinical Reviews in Allergy & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-026-09168-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12016-026-09168-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-026-09168-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T02:26:16Z","timestamp":1778120776000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12016-026-09168-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,7]]},"references-count":143,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["9168"],"URL":"https:\/\/doi.org\/10.1007\/s12016-026-09168-0","relation":{},"ISSN":["1559-0267"],"issn-type":[{"value":"1559-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,7]]},"assertion":[{"value":"16 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"41"}}