{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T07:47:37Z","timestamp":1782200857327,"version":"3.54.5"},"reference-count":186,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clinic Rev Allerg Immunol"],"DOI":"10.1007\/s12016-026-09176-0","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T18:18:23Z","timestamp":1782152303000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuropsychological Factors in Vitiligo: Mechanisms and Clinical Application"],"prefix":"10.1007","volume":"69","author":[{"given":"Fei Fei","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"issue":"4","key":"9176_CR1","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.abd.2021.09.008","volume":"97","author":"HZ Marchioro","year":"2022","unstructured":"Marchioro HZ, Silva de Castro CC, Fava VM, Sakiyama PH, Dellatorre G, Miot HA (2022) Update on the pathogenesis of vitiligo. An Bras Dermatol 97(4):478\u2013490. https:\/\/doi.org\/10.1016\/j.abd.2021.09.008","journal-title":"An Bras Dermatol"},{"issue":"1","key":"9176_CR2","first-page":"176","volume":"12","author":"L Di Bartolomeo","year":"2023","unstructured":"Di Bartolomeo L, Custurone P, Irrera N, Borgia F, Vaccaro F, Squadrito F, Vaccaro M (2023) Vitiligo and Mental Health: Natural Compounds\u2019 Usefulness. Antioxid (Basel Switzerland) 12(1):176","journal-title":"Antioxid (Basel Switzerland)"},{"issue":"1","key":"9176_CR3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1365-4362.1991.tb05870.x","volume":"30","author":"EM Farber","year":"1991","unstructured":"Farber EM, Rein G, Lanigan SW (1991) Stress and psoriasis. Psychoneuroimmunologic mechanisms. Int J Dermatol 30(1):8\u201312. https:\/\/doi.org\/10.1111\/j.1365-4362.1991.tb05870.x","journal-title":"Int J Dermatol"},{"issue":"3","key":"9176_CR4","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.clindermatol.2017.01.001","volume":"35","author":"F Cupertino","year":"2017","unstructured":"Cupertino F, Niemeyer-Corbellini JP, Ramos-E-Silva M (2017) Psychosomatic aspects of vitiligo. Clin Dermatol 35(3):292\u2013297. https:\/\/doi.org\/10.1016\/j.clindermatol.2017.01.001","journal-title":"Clin Dermatol"},{"issue":"2","key":"9176_CR5","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/j.1468-3083.2008.02764.x","volume":"23","author":"L Manolache","year":"2009","unstructured":"Manolache L, Petrescu-Seceleanu D, Benea V (2009) Correlation of stressful events with onset of vitiligo in children. J Eur Acad Dermatology Venereology: JEADV 23(2):187\u2013188. https:\/\/doi.org\/10.1111\/j.1468-3083.2008.02764.x","journal-title":"J Eur Acad Dermatology Venereology: JEADV"},{"issue":"6","key":"9176_CR6","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1046\/j.1365-2230.1998.00384.x","volume":"23","author":"L Papadopoulos","year":"1998","unstructured":"Papadopoulos L, Bor R, Legg C, Hawk JL (1998) Impact of life events on the onset of vitiligo in adults: preliminary evidence for a psychological dimension in aetiology. Clin Exp Dermatol 23(6):243\u2013248. https:\/\/doi.org\/10.1046\/j.1365-2230.1998.00384.x","journal-title":"Clin Exp Dermatol"},{"key":"9176_CR7","doi-asserted-by":"publisher","unstructured":"Le Poole C, Boissy RE (1997) Vitiligo. Semin Cutan Med Surg 16(1):3-14. https:\/\/doi.org\/10.1016\/s1085-5629(97)80030-2","DOI":"10.1016\/s1085-5629(97)80030-2"},{"issue":"1","key":"9176_CR8","doi-asserted-by":"publisher","first-page":"2504082","DOI":"10.1080\/09546634.2025.2504082","volume":"36","author":"K Ezzedine","year":"2025","unstructured":"Ezzedine K, Parsad D, Harris JE et al (2025) Depression and depressive symptoms among people living with vitiligo: findings from the cross-sectional, population-based global VALIANT survey. J Dermatological Treat 36(1):2504082. https:\/\/doi.org\/10.1080\/09546634.2025.2504082","journal-title":"J Dermatological Treat"},{"issue":"10","key":"9176_CR9","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1001\/jamadermatol.2023.2787","volume":"159","author":"K Bibeau","year":"2023","unstructured":"Bibeau K, Ezzedine K, Harris JE et al (2023) Mental health and psychosocial quality-of-life burden among patients with vitiligo: findings from the global VALIANT study. JAMA Dermatology 159(10):1124\u20131128. https:\/\/doi.org\/10.1001\/jamadermatol.2023.2787","journal-title":"JAMA Dermatology"},{"issue":"3","key":"9176_CR10","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1111\/bjd.15199","volume":"177","author":"YC Lai","year":"2017","unstructured":"Lai YC, Yew YW, Kennedy C, Schwartz RA (2017) Vitiligo and depression: a systematic review and meta-analysis of observational studies. Br J Dermatol 177(3):708\u2013718. https:\/\/doi.org\/10.1111\/bjd.15199","journal-title":"Br J Dermatol"},{"issue":"5","key":"9176_CR11","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1016\/j.jaad.2018.11.047","volume":"80","author":"IA Vallerand","year":"2019","unstructured":"Vallerand IA, Lewinson RT, Parsons LM, Hardin J, Haber RM, Lowerison MW, Barnabe C, Patten SB (2019) Vitiligo and major depressive disorder: A bidirectional population-based cohort study. J Am Acad Dermatol 80(5):1371\u20131379. https:\/\/doi.org\/10.1016\/j.jaad.2018.11.047","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"9176_CR12","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1111\/bjd.16049","volume":"178","author":"O Osinubi","year":"2018","unstructured":"Osinubi O, Grainge MJ, Hong L, Ahmed A, Batchelor JM, Grindlay D, Thompson AR, Ratib S (2018) The prevalence of psychological comorbidity in people with vitiligo: a systematic review and meta-analysis. Br J Dermatol 178(4):863\u2013878. https:\/\/doi.org\/10.1111\/bjd.16049","journal-title":"Br J Dermatol"},{"issue":"2","key":"9176_CR13","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.cell.2009.07.049","volume":"139","author":"I Adameyko","year":"2009","unstructured":"Adameyko I, Lallemend F, Aquino JB, Pereira JA, Topilko P, M\u00fcller T, Fritz N, Beljajeva A, Mochii M, Liste I, Usoskin D, Suter U, Birchmeier C, Ernfors P (2009) Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin. Cell 139(2):366\u2013379. https:\/\/doi.org\/10.1016\/j.cell.2009.07.049","journal-title":"Cell"},{"issue":"4","key":"9176_CR14","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1084\/jem.184.4.1385","volume":"184","author":"M Hara","year":"1996","unstructured":"Hara M, Toyoda M, Yaar M, Bhawan J, Avila EM, Penner IR, Gilchrest BA (1996) Innervation of melanocytes in human skin. J Exp Med 184(4):1385\u20131395. https:\/\/doi.org\/10.1084\/jem.184.4.1385","journal-title":"J Exp Med"},{"issue":"2","key":"9176_CR15","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1093\/bjd\/ljac066","volume":"188","author":"M Talagas","year":"2023","unstructured":"Talagas M (2023) Anatomical contacts between sensory neurons and epidermal cells: an unrecognized anatomical network for neuro-immuno-cutaneous crosstalk. Br J Dermatol 188(2):176\u2013185. https:\/\/doi.org\/10.1093\/bjd\/ljac066","journal-title":"Br J Dermatol"},{"issue":"2","key":"9176_CR16","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3109\/02844316809010488","volume":"2","author":"G Eriksson","year":"1968","unstructured":"Eriksson G, Klingenstr\u00f6m P, Nyl\u00e9n B, Wers\u00e4ll J (1968) Electron microscopic studies on the epidermis in human split-skin autografts. Scand J Plast Reconstr Surg 2(2):83\u201390. https:\/\/doi.org\/10.3109\/02844316809010488","journal-title":"Scand J Plast Reconstr Surg"},{"issue":"6","key":"9176_CR17","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1001\/archderm.1977.01640060051004","volume":"113","author":"M Morohashi","year":"1977","unstructured":"Morohashi M, Hashimoto K, Goodman TF Jr, Newton DE, Rist T (1977) Ultrastructural studies of vitiligo, Vogt-Koyanagi syndrome, and incontinentia pigmenti achromians. Arch Dermatol 113(6):755\u2013766","journal-title":"Arch Dermatol"},{"issue":"3","key":"9176_CR18","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1076\/1381345520000710831zft262","volume":"108","author":"R Lazarova","year":"2000","unstructured":"Lazarova R, Hristakieva E, Lazarov N, Shani J (2000) Vitiligo-related neuropeptides in nerve fibers of the skin. Arch Physiol Biochem 108(3):262\u2013267. https:\/\/doi.org\/10.1076\/1381345520000710831zft262","journal-title":"Arch Physiol Biochem"},{"key":"9176_CR19","doi-asserted-by":"publisher","unstructured":"Christoph Erbacher S, Britz P, Dinkel T, Klein M, Sauer C, Stigloher N \u00dc\u00e7eyler (2024) Interaction of human keratinocytes and nerve fiber terminals at the neuro-cutaneous unit. eLife 13:e77761. https:\/\/doi.org\/10.7554\/eLife.77761","DOI":"10.7554\/eLife.77761"},{"issue":"4","key":"9176_CR20","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.npep.2006.06.002","volume":"40","author":"A Dallos","year":"2006","unstructured":"Dallos A, Kiss M, Poly\u00e1nka H, Dobozy A, Kem\u00e9ny L, Husz S (2006) Effects of the neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide and galanin on the production of nerve growth factor and inflammatory cytokines in cultured human keratinocytes. Neuropeptides 40(4):251\u2013263. https:\/\/doi.org\/10.1016\/j.npep.2006.06.002","journal-title":"Neuropeptides"},{"key":"9176_CR21","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.regpep.2013.08.001","volume":"186","author":"X Shi","year":"2013","unstructured":"Shi X, Wang L, Clark JD, Kingery WS (2013) Keratinocytes express cytokines and nerve growth factor in response to neuropeptide activation of the ERK1\/2 and JNK MAPK transcription pathways. Regul Pept 186:92\u2013103. https:\/\/doi.org\/10.1016\/j.regpep.2013.08.001","journal-title":"Regul Pept"},{"issue":"5","key":"9176_CR22","doi-asserted-by":"publisher","first-page":"598","DOI":"10.4103\/aian.AIAN_466_19","volume":"23","author":"S Yadav","year":"2020","unstructured":"Yadav S (2020) Insight into Neurodegenerative Disorder Using Melanocytes as a Model System. Ann Indian Acad Neurol 23(5):598\u2013601. https:\/\/doi.org\/10.4103\/aian.AIAN_466_19","journal-title":"Ann Indian Acad Neurol"},{"key":"9176_CR23","doi-asserted-by":"publisher","first-page":"155432","DOI":"10.1016\/j.cyto.2021.155432","volume":"140","author":"M Singh","year":"2021","unstructured":"Singh M, Mansuri MS, Kadam A, Palit SP, Dwivedi M, Laddha NC, Begum R (2021) Tumor Necrosis Factor-alpha affects melanocyte survival and melanin synthesis via multiple pathways in vitiligo. Cytokine 140:155432. https:\/\/doi.org\/10.1016\/j.cyto.2021.155432","journal-title":"Cytokine"},{"issue":"6","key":"9176_CR24","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1046\/j.1523-1747.2000.00130.x","volume":"115","author":"YL Li","year":"2000","unstructured":"Li YL, Yu CL, Yu HS (2000) IgG anti-melanocyte antibodies purified from patients with active vitiligo induce HLA-DR and intercellular adhesion molecule-1 expression and an increase in interleukin-8 release by melanocytes. J Invest Dermatol 115(6):969\u2013973. https:\/\/doi.org\/10.1046\/j.1523-1747.2000.00130.x","journal-title":"J Invest Dermatol"},{"issue":"1","key":"9176_CR25","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/ced.12164","volume":"39","author":"A Miniati","year":"2014","unstructured":"Miniati A, Weng Z, Zhang B, Therianou A, Vasiadi M, Nicolaidou E, Stratigos AJ, Antoniou C, Theoharides TC (2014) Stimulated human melanocytes express and release interleukin-8, which is inhibited by luteolin: relevance to early vitiligo. Clin Exp Dermatol 39(1):54\u201357. https:\/\/doi.org\/10.1111\/ced.12164","journal-title":"Clin Exp Dermatol"},{"issue":"11","key":"9176_CR26","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1038\/jid.2012.181","volume":"132","author":"S Toosi","year":"2012","unstructured":"Toosi S, Orlow SJ, Manga P (2012) Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8. J Invest Dermatol 132(11):2601\u20132609. https:\/\/doi.org\/10.1038\/jid.2012.181","journal-title":"J Invest Dermatol"},{"key":"9176_CR27","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/978-3-642-78771-3_12","volume":"139","author":"K Krasagakis","year":"1995","unstructured":"Krasagakis K, Garbe C, Zouboulis CC, Orfanos CE (1995) Growth control of melanoma cells and melanocytes by cytokines. Recent results in cancer research. Fortschr der Krebsforschung Progres dans les recherches sur le cancer 139:169\u2013182. https:\/\/doi.org\/10.1007\/978-3-642-78771-3_12","journal-title":"Fortschr der Krebsforschung Progres dans les recherches sur le cancer"},{"issue":"4","key":"9176_CR28","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/j.1467-2494.2006.00321.x","volume":"28","author":"A Marconi","year":"2006","unstructured":"Marconi A, Panza MC, Bonnet-Duquennoy M, Lazou K, Kurfurst R, Truzzi F, Lotti R, De Santis G, Dumas M, Bont\u00e9 F, Pincelli C (2006) Expression and function of neurotrophins and their receptors in human melanocytes. Int J Cosmet Sci 28(4):255\u2013261. https:\/\/doi.org\/10.1111\/j.1467-2494.2006.00321.x","journal-title":"Int J Cosmet Sci"},{"key":"9176_CR29","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1146\/annurev.biochem.72.121801.161629","volume":"72","author":"EJ Huang","year":"2003","unstructured":"Huang EJ, Reichardt LF (2003) Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem 72:609\u2013642. https:\/\/doi.org\/10.1146\/annurev.biochem.72.121801.161629","journal-title":"Annu Rev Biochem"},{"key":"9176_CR30","doi-asserted-by":"publisher","first-page":"148070","DOI":"10.1016\/j.brainres.2022.148070","volume":"1796","author":"SL Bachman","year":"2022","unstructured":"Bachman SL, Nashiro K, Yoo H, Wang D, Thayer JF, Mather M (2022) Associations between locus coeruleus MRI contrast and physiological responses to acute stress in younger and older adults. Brain Res 1796:148070. https:\/\/doi.org\/10.1016\/j.brainres.2022.148070","journal-title":"Brain Res"},{"key":"9176_CR31","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1159\/000106420","volume":"35","author":"L Pavlovsky","year":"2007","unstructured":"Pavlovsky L, Friedman A (2007) Pathogenesis of stress-associated skin disorders: exploring the brain-skin axis. Curr Probl Dermatol 35:136\u2013145. https:\/\/doi.org\/10.1159\/000106420","journal-title":"Curr Probl Dermatol"},{"key":"9176_CR32","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/B978-0-444-64032-1.00027-8","volume":"160","author":"CH Gibbons","year":"2019","unstructured":"Gibbons CH (2019) Basics of autonomic nervous system function. Handb Clin Neurol 160:407\u2013418. https:\/\/doi.org\/10.1016\/B978-0-444-64032-1.00027-8","journal-title":"Handb Clin Neurol"},{"key":"9176_CR33","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0923-1811(99)00090-0","volume":"23","author":"CS Wu","year":"2000","unstructured":"Wu CS, Yu HS, Chang HR, Yu CL, Yu CL, Wu BN (2000) Cutaneous blood flow and adrenoceptor response increase in segmentaltype vitiligo lesions. J Dermatol Sci 23:53\u201362. https:\/\/doi.org\/10.1016\/S0923-1811(99)00090-0","journal-title":"J Dermatol Sci"},{"issue":"1","key":"9176_CR34","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/jidsymp.1997.9","volume":"2","author":"KU Schallreuter","year":"1997","unstructured":"Schallreuter KU (1997) Epidermal adrenergic signal transduction as part of the neuronal network in the human epidermis. J Investig Dermatol Symp Proc 2(1):37\u201340. https:\/\/doi.org\/10.1038\/jidsymp.1997.9","journal-title":"J Invest Dermatol"},{"issue":"6","key":"9176_CR35","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1111\/1523-1747.ep12606218","volume":"104","author":"KU Schallreuter","year":"1995","unstructured":"Schallreuter KU, Lemke KR, Pittelkow MR, Wood JM, K\u00f6rner C, Malik R (1995) Catecholamines in Human Keratinocyte Differentiation. J Invest Dermatology 104(6):953\u2013957. https:\/\/doi.org\/10.1111\/1523-1747.ep12606218","journal-title":"J Invest Dermatology"},{"issue":"1","key":"9176_CR36","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/BF02505037","volume":"288","author":"KU Schallreuter","year":"1996","unstructured":"Schallreuter KU, Wood JM, Pittelkow MR, Buttner G, Swanson N, Korner C, Ehrke C (1996) Increased monoamine oxidase A activity in the epidermis of patients with vitiligo. Arch Dermatol Res 288(1):14\u201318. https:\/\/doi.org\/10.1007\/BF02505037","journal-title":"Arch Dermatol Res"},{"issue":"2","key":"9176_CR37","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s00403-022-02333-3","volume":"315","author":"S Tanwar","year":"2023","unstructured":"Tanwar S, Thakur V, Bhatia A, Parsad D (2023) Catecholamines\u2019 accumulation and their disturbed metabolism at perilesional site: a possible cause of vitiligo progression. Arch Dermatol Res 315(2):173\u2013180. https:\/\/doi.org\/10.1007\/s00403-022-02333-3","journal-title":"Arch Dermatol Res"},{"key":"9176_CR38","doi-asserted-by":"publisher","first-page":"1466996","DOI":"10.3389\/fmed.2025.1466996","volume":"12","author":"Z Hu","year":"2025","unstructured":"Hu Z, Chen T, Chen D (2025) Local sympathetic nerve depletion does not alter vitiligo progression in a mouse model. Front Med 12:1466996. https:\/\/doi.org\/10.3389\/fmed.2025.1466996","journal-title":"Front Med"},{"issue":"10","key":"9176_CR39","doi-asserted-by":"publisher","first-page":"eaea7017","DOI":"10.1126\/sciadv.aea7017","volume":"12","author":"L Huang","year":"2026","unstructured":"Huang L, Kang P, Chen J, Sun W, Yin H, Yang Y, Guo S, Yi X, Chen J, Li S, Li C (2026) Sympathetic nerve aggravates autoimmune skin disease via NE-adrenergic receptor axis: Neuroimmune cross-talk insights from vitiligo. Sci Adv 12(10):eaea7017. https:\/\/doi.org\/10.1126\/sciadv.aea7017","journal-title":"Sci Adv"},{"key":"9176_CR40","doi-asserted-by":"publisher","unstructured":"Orecchia GE (2000) Neural pathogenesis. In: Hann S-K, Nordlund JJ, Lerner AB (eds) Vitiligo. https:\/\/doi.org\/10.1002\/9780470760116.ch18","DOI":"10.1002\/9780470760116.ch18"},{"issue":"2","key":"9176_CR41","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/j.1365-2133.1996.tb07618.x","volume":"134","author":"A Norris","year":"1996","unstructured":"Norris A, Todd C, Graham A, Quinn AG, Thody AJ (1996) The expression of the c-kit receptor by epidermal melanocytes may be reduced in vitiligo. Br J Dermatol 134(2):299\u2013306","journal-title":"Br J Dermatol"},{"issue":"4","key":"9176_CR42","doi-asserted-by":"publisher","first-page":"762","DOI":"10.5114\/ada.2021.110266","volume":"39","author":"D Wilamowska-Kokoszko","year":"2022","unstructured":"Wilamowska-Kokoszko D, \u0141ukasik K, Szepietowski JC, Skar\u017cynski DJ, Owczarczyk-Saczonek A, Hlebowicz-Skrodzka J, Placek WJ (2022) Assessment of stem cell factor expression and its c-KIT receptor in patients with vitiligo. Postepy dermatologii i alergologii 39(4):762\u2013767. https:\/\/doi.org\/10.5114\/ada.2021.110266","journal-title":"Postepy dermatologii i alergologii"},{"issue":"1","key":"9176_CR43","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jep.2008.03.021","volume":"118","author":"L Wen-Jun","year":"2008","unstructured":"Wen-Jun L, Hai-Yan W, Wei L, Ke-Yu W, Rui-Ming W (2008) Evidence that geniposide abrogates norepinephrine-induced hypopigmentation by the activation of GLP-1R-dependent c-kit receptor signaling in melanocyte. J Ethnopharmacol 118(1):154\u2013158. https:\/\/doi.org\/10.1016\/j.jep.2008.03.021","journal-title":"J Ethnopharmacol"},{"issue":"24","key":"9176_CR44","doi-asserted-by":"publisher","first-page":"5379","DOI":"10.1242\/dev.127.24.5379","volume":"127","author":"L Hou","year":"2000","unstructured":"Hou L, Panthier JJ, Arnheiter H (2000) Signaling and transcriptional regulation in the neural crest-derived melanocyte lineage: interactions between KIT and MITF. Development 127(24):5379\u20135389. https:\/\/doi.org\/10.1242\/dev.127.24.5379","journal-title":"Development"},{"issue":"2","key":"9176_CR45","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/j.1600-0749.2003.00126.x","volume":"17","author":"G Imokawa","year":"2004","unstructured":"Imokawa G (2004) Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders. Pigment Cell Res 17(2):96\u2013110. https:\/\/doi.org\/10.1111\/j.1600-0749.2003.00126.x","journal-title":"Pigment Cell Res"},{"issue":"1\u20132","key":"9176_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1385\/IR:35:1:1","volume":"35","author":"SA Berger","year":"2006","unstructured":"Berger SA (2006) Signaling pathways influencing SLF and c-kit-mediated survival and proliferation. Immunol Res 35(1\u20132):1\u201312. https:\/\/doi.org\/10.1385\/IR:35:1:1","journal-title":"Immunol Res"},{"issue":"7792","key":"9176_CR47","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/s41586-020-1935-3","volume":"577","author":"B Zhang","year":"2020","unstructured":"Zhang B, Ma S, Rachmin I, He M, Baral P, Choi S, Gon\u00e7alves WA, Shwartz Y, Fast EM, Su Y, Zon LI, Regev A, Buenrostro JD, Cunha TM, Chiu IM, Fisher DE, Hsu YC (2020) Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature 577(7792):676\u2013681. https:\/\/doi.org\/10.1038\/s41586-020-1935-3","journal-title":"Nature"},{"issue":"10","key":"9176_CR48","doi-asserted-by":"publisher","first-page":"937","DOI":"10.14670\/HH-18-470","volume":"37","author":"ZH Wang","year":"2022","unstructured":"Wang ZH, Liu LP, Zheng YW (2022) Melanocyte stem cells in skin diseases and their potential in cell-based therapy. Histol Histopathol 37(10):937\u2013953. https:\/\/doi.org\/10.14670\/HH-18-470","journal-title":"Histol Histopathol"},{"key":"9176_CR49","doi-asserted-by":"publisher","unstructured":"Brielle ES-SS, Mann AO, Khoury MJ, Peng J, Tellez L, Harrigan M, Ziogas M, Amalia Pasolli H, Cassandras M, Getzler AJ, Freeman R, Zhang B, Shwartz Y, Agudo J, Franklin RA, Hsu Y-C (2025) Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity. Cell. https:\/\/doi.org\/10.1016\/j.cell.2025.10.042","DOI":"10.1016\/j.cell.2025.10.042"},{"issue":"4","key":"9176_CR50","doi-asserted-by":"publisher","first-page":"584","DOI":"10.18632\/oncotarget.965","volume":"4","author":"A Hall","year":"2013","unstructured":"Hall A, Meyle KD, Lange MK, Klima M, Sanderhoff M, Dahl C, Abildgaard C, Thorup K, Moghimi SM, Jensen PB, Bartek J, Guldberg P, Christensen C (2013) Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the (V600E)BRAF oncogene. Oncotarget 4(4):584\u2013599. https:\/\/doi.org\/10.18632\/oncotarget.965","journal-title":"Oncotarget"},{"issue":"4","key":"9176_CR51","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1111\/pcmr.13165","volume":"37","author":"M Snyman","year":"2024","unstructured":"Snyman M, Walsdorf RE, Wix SN, Gill JG (2024) The metabolism of melanin synthesis-From melanocytes to melanoma. Pigment cell melanoma Res 37(4):438\u2013452. https:\/\/doi.org\/10.1111\/pcmr.13165","journal-title":"Pigment cell melanoma Res"},{"key":"9176_CR52","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s12016-025-09040-7","volume":"68","author":"H Zhang","year":"2025","unstructured":"Zhang H, Xia M, Li H et al (2025) Implication of Immunobiological Function of Melanocytes in Dermatology. Clin Rev Allerg Immunol 68:30. https:\/\/doi.org\/10.1007\/s12016-025-09040-7","journal-title":"Clin Rev Allerg Immunol"},{"issue":"2","key":"9176_CR53","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/j.1600-0749.1992.tb00003.x","volume":"5","author":"A Morrone","year":"1992","unstructured":"Morrone A, Picardo M, de Luca C, Terminali O, Passi S, Ippolito F (1992) Catecholamines and vitiligo. Pigment Cell Res 5(2):65\u201369. https:\/\/doi.org\/10.1111\/j.1600-0749.1992.tb00003.x","journal-title":"Pigment Cell Res"},{"issue":"1","key":"9176_CR54","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1034\/j.1600-0749.2000.130106.x","volume":"13","author":"ML Cucchi","year":"2000","unstructured":"Cucchi ML, Frattini P, Santagostino G, Orecchia G (2000) Higher plasma catecholamine and metabolite levels in the early phase of nonsegmental vitiligo. Pigment Cell Res 13(1):28\u201332. https:\/\/doi.org\/10.1034\/j.1600-0749.2000.130106.x","journal-title":"Pigment Cell Res"},{"issue":"6","key":"9176_CR55","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1111\/1523-1747.ep12492612","volume":"97","author":"KU Schallreuter","year":"1991","unstructured":"Schallreuter KU, Wood JM, Berger J (1991) Low catalase levels in the epidermis of patients with vitiligo. J Invest Dermatol 97(6):1081\u20131085. https:\/\/doi.org\/10.1111\/1523-1747.ep12492612","journal-title":"J Invest Dermatol"},{"issue":"1","key":"9176_CR56","doi-asserted-by":"publisher","first-page":"43","DOI":"10.4161\/oxim.2.1.7732","volume":"2","author":"K Fisher-Wellman","year":"2009","unstructured":"Fisher-Wellman K, Bell HK, Bloomer RJ (2009) Oxidative stress and antioxidant defense mechanisms linked to exercise during cardiopulmonary and metabolic disorders. Oxidative Med Cell Longev 2(1):43\u201351. https:\/\/doi.org\/10.4161\/oxim.2.1.7732","journal-title":"Oxidative Med Cell Longev"},{"issue":"5338","key":"9176_CR57","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1126\/science.278.5338.687","volume":"278","author":"L del Peso","year":"1997","unstructured":"del Peso L, Gonz\u00e1lez-Garc\u00eda M, Page C, Herrera R, Nu\u00f1ez G (1997) Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Sci (New York) 278(5338):687\u2013689. https:\/\/doi.org\/10.1126\/science.278.5338.687","journal-title":"Sci (New York)"},{"issue":"4","key":"9176_CR58","doi-asserted-by":"publisher","first-page":"E794","DOI":"10.1152\/ajpendo.00791.2007","volume":"294","author":"C Dufour","year":"2008","unstructured":"Dufour C, Holy X, Marie PJ (2008) Transforming growth factor-beta prevents osteoblast apoptosis induced by skeletal unloading via PI3K\/Akt, Bcl-2, and phospho-Bad signaling. Am J Physiol Endocrinol Metab 294(4):E794\u2013E801. https:\/\/doi.org\/10.1152\/ajpendo.00791.2007","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"2","key":"9176_CR59","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jdermsci.2007.03.009","volume":"47","author":"ES Park","year":"2007","unstructured":"Park ES, Kim SY, Na JI, Ryu HS, Youn SW, Kim DS, Yun HY, Park KC (2007) Glutathione prevented dopamine-induced apoptosis of melanocytes and its signaling. J Dermatol Sci 47(2):141\u2013149. https:\/\/doi.org\/10.1016\/j.jdermsci.2007.03.009","journal-title":"J Dermatol Sci"},{"issue":"10","key":"9176_CR60","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1111\/ijd.16166","volume":"61","author":"S Tanwar","year":"2022","unstructured":"Tanwar S, Thakur V, Parsad D (2022) Dopamine toxicity contributes to melanocyte loss via melanocytorrhagy: an in vitro study. Int J Dermatol 61(10):1253\u20131261. https:\/\/doi.org\/10.1111\/ijd.16166","journal-title":"Int J Dermatol"},{"issue":"1","key":"9176_CR61","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1124\/pharmrev.122.000618","volume":"75","author":"B Channer","year":"2023","unstructured":"Channer B, Matt SM, Nickoloff-Bybel EA, Pappa V, Agarwal Y, Wickman J, Gaskill PJ (2023) Dopamine, Immunity, and Disease. Pharmacol Rev 75(1):62\u2013158. https:\/\/doi.org\/10.1124\/pharmrev.122.000618","journal-title":"Pharmacol Rev"},{"issue":"2","key":"9176_CR62","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.jaad.2008.09.048","volume":"60","author":"PY Basak","year":"2009","unstructured":"Basak PY, Adiloglu AK, Ceyhan AM, Tas T, Akkaya VB (2009) The role of helper and regulatory T cells in the pathogenesis of vitiligo. J Am Acad Dermatol 60(2):256\u2013260. https:\/\/doi.org\/10.1016\/j.jaad.2008.09.048","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"9176_CR63","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/j.1755-148X.2011.00945.x","volume":"25","author":"Y Kotobuki","year":"2012","unstructured":"Kotobuki Y, Tanemura A, Yang L, Itoi S, Wataya-Kaneda M, Murota H, Fujimoto M, Serada S, Naka T, Katayama I (2012) Dysregulation of melanocyte function by Th17-related cytokines: significance of Th17 cell infiltration in autoimmune vitiligo vulgaris. Pigment cell melanoma Res 25(2):219\u2013230. https:\/\/doi.org\/10.1111\/j.1755-148X.2011.00945.x","journal-title":"Pigment cell melanoma Res"},{"issue":"8","key":"9176_CR64","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1084\/jem.20070663","volume":"204","author":"F Annunziato","year":"2007","unstructured":"Annunziato F, Cosmi L, Santarlasci V, Maggi L, Liotta F, Mazzinghi B, Parente E, Fil\u00ec L, Ferri S, Frosali F, Giudici F, Romagnani P, Parronchi P, Tonelli F, Maggi E, Romagnani S (2007) Phenotypic and functional features of human Th17 cells. J Exp Med 204(8):1849\u20131861. https:\/\/doi.org\/10.1084\/jem.20070663","journal-title":"J Exp Med"},{"issue":"1","key":"9176_CR65","doi-asserted-by":"publisher","first-page":"214","DOI":"10.4049\/jimmunol.180.1.214","volume":"180","author":"SP Singh","year":"2008","unstructured":"Singh SP, Zhang HH, Foley JF, Hedrick MN, Farber JM (2008) Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. J Immunol (Baltimore Md : 1950) 180(1):214\u2013221. https:\/\/doi.org\/10.4049\/jimmunol.180.1.214","journal-title":"J Immunol (Baltimore Md : 1950)"},{"issue":"5","key":"9176_CR66","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.immuni.2009.09.014","volume":"31","author":"N Martin-Orozco","year":"2009","unstructured":"Martin-Orozco N, Muranski P, Chung Y, Yang XO, Yamazaki T, Lu S, Hwu P, Restifo NP, Overwijk WW, Dong C (2009) T helper 17 cells promote cytotoxic T cell activation in tumor immunity. Immunity 31(5):787\u2013798. https:\/\/doi.org\/10.1016\/j.immuni.2009.09.014","journal-title":"Immunity"},{"key":"9176_CR67","doi-asserted-by":"publisher","unstructured":"Luiten RM, Van Den Boorn JG, Konijnenberg D, Dellemijn TAM, Van Der Veen JP W, Bos JD, \u2026, Vyth-Dreese FA (2009) Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients. J Invest Dermatol 129(9):2220\u20132232. https:\/\/doi.org\/10.1038\/jid.2009.32","DOI":"10.1038\/jid.2009.32"},{"issue":"2","key":"9176_CR68","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1182\/blood-2007-11-120998","volume":"112","author":"P Muranski","year":"2008","unstructured":"Muranski P, Boni A, Antony PA, Cassard L, Irvine KR, Kaiser A, Paulos CM, Palmer DC, Touloukian CE, Ptak K, Gattinoni L, Wrzesinski C, Hinrichs CS, Kerstann KW, Feigenbaum L, Chan CC, Restifo NP (2008) Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood 112(2):362\u2013373. https:\/\/doi.org\/10.1182\/blood-2007-11-120998","journal-title":"Blood"},{"issue":"1","key":"9176_CR69","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/cei.12146","volume":"174","author":"S You","year":"2013","unstructured":"You S, Cho YH, Byun JS, Shin EC (2013) Melanocyte-specific CD8\u2009+\u2009T cells are associated with epidermal depigmentation in a novel mouse model of vitiligo. Clin Exp Immunol 174(1):38\u201344. https:\/\/doi.org\/10.1111\/cei.12146","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"9176_CR70","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1684\/ejd.2013.2011","volume":"23","author":"BX Zhang","year":"2013","unstructured":"Zhang BX, Lin M, Qi XY, Zhang RX, Wei ZD, Zhu J, Man MQ, Tu CX (2013) Characterization of circulating CD8\u2009+\u2009T cells expressing skin homing and cytotoxic molecules in active non-segmental vitiligo. Eur J dermatology: EJD 23(3):331\u2013338. https:\/\/doi.org\/10.1684\/ejd.2013.2011","journal-title":"Eur J dermatology: EJD"},{"issue":"1","key":"9176_CR71","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3892\/mmr.2012.1117","volume":"7","author":"J Wu","year":"2013","unstructured":"Wu J, Zhou M, Wan Y, Xu A (2013) CD8\u2009+\u2009T cells from vitiligo perilesional margins induce autologous melanocyte apoptosis. Mol Med Rep 7(1):237\u2013241. https:\/\/doi.org\/10.3892\/mmr.2012.1117","journal-title":"Mol Med Rep"},{"issue":"8","key":"9176_CR72","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1111\/ijd.12160","volume":"53","author":"M Abdallah","year":"2014","unstructured":"Abdallah M, Lotfi R, Othman W, Galal R (2014) Assessment of tissue FoxP3+, CD4\u2009+\u2009and CD8\u2009+\u2009T-cells in active and stable nonsegmental vitiligo. Int J Dermatol 53(8):940\u2013946. https:\/\/doi.org\/10.1111\/ijd.12160","journal-title":"Int J Dermatol"},{"issue":"4\u20135","key":"9176_CR73","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.autrev.2014.01.050","volume":"13","author":"E Suzuki","year":"2014","unstructured":"Suzuki E, Mellins ED, Gershwin ME, Nestle FO, Adamopoulos IE (2014) The IL-23\/IL-17 axis in psoriatic arthritis. Autoimmun rev 13(4\u20135):496\u2013502. https:\/\/doi.org\/10.1016\/j.autrev.2014.01.050","journal-title":"Autoimmun rev"},{"issue":"2","key":"9176_CR74","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/1523-1747.ep12556058","volume":"98","author":"JM Schr\u00f6der","year":"1992","unstructured":"Schr\u00f6der JM, Gregory H, Young J, Christophers E (1992) Neutrophil-activating proteins in psoriasis. J Invest Dermatol 98(2):241\u2013247. https:\/\/doi.org\/10.1111\/1523-1747.ep12556058","journal-title":"J Invest Dermatol"},{"issue":"4","key":"9176_CR75","first-page":"1219","volume":"148","author":"IC Le Poole","year":"1996","unstructured":"Le Poole IC, van den Wijngaard RM, Westerhof W, Das PK (1996) Presence of T cells and macrophages in inflammatory vitiligo skin parallels melanocyte disappearance. Am J Pathol 148(4):1219\u20131228","journal-title":"Am J Pathol"},{"issue":"2","key":"9176_CR76","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/j.1365-2133.1984.tb04037.x","volume":"111","author":"W Gli\u0144ski","year":"1984","unstructured":"Gli\u0144ski W, Barszcz D, Janczura E, Zarebska Z, Jab\u0142o\u0144ska S (1984) Neutral proteinases and other neutrophil enzymes in psoriasis, and their relation to disease activity. Br J Dermatol 111(2):147\u2013154. https:\/\/doi.org\/10.1111\/j.1365-2133.1984.tb04037.x","journal-title":"Br J Dermatol"},{"issue":"10","key":"9176_CR77","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1007\/s00403-009-0964-4","volume":"301","author":"R Khan","year":"2009","unstructured":"Khan R, Satyam A, Gupta S, Sharma VK, Sharma A (2009) Circulatory levels of antioxidants and lipid peroxidation in Indian patients with generalized and localized vitiligo. Arch Dermatol Res 301(10):731\u2013737. https:\/\/doi.org\/10.1007\/s00403-009-0964-4","journal-title":"Arch Dermatol Res"},{"key":"9176_CR78","doi-asserted-by":"publisher","unstructured":"Pickens SR, Volin MV, Mandelin AM 2nd, Kolls JK, Pope RM, Shahrara S (2010) IL-17 contributes to angiogenesis in rheumatoid arthritis. J Immunol (Baltimore, Md.: 1950) 184(6):3233\u20133241. https:\/\/doi.org\/10.4049\/jimmunol.0903271","DOI":"10.4049\/jimmunol.0903271"},{"issue":"7","key":"9176_CR79","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1002\/eji.201040707","volume":"40","author":"B Silva-Santos","year":"2010","unstructured":"Silva-Santos B (2010) Promoting angiogenesis within the tumor microenvironment: the secret life of murine lymphoid IL-17-producing gammadelta T cells. Eur J Immunol 40(7):1873\u20131876. https:\/\/doi.org\/10.1002\/eji.201040707","journal-title":"Eur J Immunol"},{"issue":"2","key":"9176_CR80","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.bbrc.2011.03.021","volume":"407","author":"J Liu","year":"2011","unstructured":"Liu J, Duan Y, Cheng X, Chen X, Xie W, Long H, Lin Z, Zhu B (2011) IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma. Biochem Biophys Res Commun 407(2):348\u2013354. https:\/\/doi.org\/10.1016\/j.bbrc.2011.03.021","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"9176_CR81","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/1523-1747.ep12499793","volume":"98","author":"R Kirnbauer","year":"1992","unstructured":"Kirnbauer R, Charvat B, Schauer E, K\u00f6ck A, Urbanski A, F\u00f6rster E, Neuner P, Assmann I, Luger TA, Schwarz T (1992) Modulation of intercellular adhesion molecule-1 expression on human melanocytes and melanoma cells: evidence for a regulatory role of IL-6, IL-7, TNF beta, and UVB light. J Invest Dermatol 98(3):320\u2013326. https:\/\/doi.org\/10.1111\/1523-1747.ep12499793","journal-title":"J Invest Dermatol"},{"issue":"1","key":"9176_CR82","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1080\/08820139.2020.1813756","volume":"51","author":"M Singh","year":"2022","unstructured":"Singh M, Jadeja SD, Vaishnav J, Mansuri MS, Shah C, Mayatra JM, Shah A, Begum R (2022) Investigation of the Role of Interleukin 6 in Vitiligo Pathogenesis. Immunol Investig 51(1):120\u2013137. https:\/\/doi.org\/10.1080\/08820139.2020.1813756","journal-title":"Immunol Investig"},{"issue":"223","key":"9176_CR83","doi-asserted-by":"publisher","first-page":"223ra23","DOI":"10.1126\/scitranslmed.3007811","volume":"6","author":"M Rashighi","year":"2014","unstructured":"Rashighi M, Agarwal P, Richmond JM, Harris TH, Dresser K, Su MW, Zhou Y, Deng A, Hunter CA, Luster AD, Harris JE (2014) CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo. Sci Transl Med 6(223):223ra23. https:\/\/doi.org\/10.1126\/scitranslmed.3007811","journal-title":"Sci Transl Med"},{"issue":"1","key":"9176_CR84","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jphs.2019.05.005","volume":"141","author":"M Cai","year":"2019","unstructured":"Cai M, Zhou L, Liao J, Huang Q, Xia Z, Shang J (2019) IFN-\u03b3 inhibits 5-HT-induced melanin biosynthesis via downregulation of 5-HT receptors in vivo\/in vitro. J Pharmacol Sci 141(1):1\u20138. https:\/\/doi.org\/10.1016\/j.jphs.2019.05.005","journal-title":"J Pharmacol Sci"},{"issue":"610","key":"9176_CR85","doi-asserted-by":"publisher","first-page":"eabd8995","DOI":"10.1126\/scitranslmed.abd8995","volume":"13","author":"KJ Gellatly","year":"2021","unstructured":"Gellatly KJ, Strassner JP, Essien K, Refat MA, Murphy RL, Coffin-Schmitt A, Pandya AG, Tovar-Garza A, Frisoli ML, Fan X, Ding X, Kim EE, Abbas Z, McDonel P, Garber M, Harris JE (2021) scRNA-seq of human vitiligo reveals complex networks of subclinical immune activation and a role for CCR5 in Treg function. Sci Transl Med 13(610):eabd8995. https:\/\/doi.org\/10.1126\/scitranslmed.abd8995","journal-title":"Sci Transl Med"},{"issue":"1","key":"9176_CR86","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1002\/jcp.20839","volume":"210","author":"CN Nagineni","year":"2007","unstructured":"Nagineni CN, Cherukuri KS, Kutty V, Detrick B, Hooks JJ (2007) Interferon-gamma differentially regulates TGF-beta1 and TGF-beta2 expression in human retinal pigment epithelial cells through JAK-STAT pathway. J Cell Physiol 210(1):192\u2013200. https:\/\/doi.org\/10.1002\/jcp.20839","journal-title":"J Cell Physiol"},{"issue":"10","key":"9176_CR87","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1258\/ebm.2010.009331","volume":"235","author":"A Thorsell","year":"2010","unstructured":"Thorsell A (2010) Brain neuropeptide Y and corticotropin-releasing hormone in mediating stress and anxiety. Experimental biology and medicine. (Maywood NJ) 235(10):1163\u20131167. https:\/\/doi.org\/10.1258\/ebm.2010.009331","journal-title":"(Maywood NJ)"},{"issue":"23","key":"9176_CR88","doi-asserted-by":"publisher","first-page":"12852","DOI":"10.1073\/pnas.220232997","volume":"97","author":"A Thorsell","year":"2000","unstructured":"Thorsell A, Michalkiewicz M, Dumont Y, Quirion R, Caberlotto L, Rimondini R, Math\u00e9 AA, Heilig M (2000) Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression. Proc Natl Acad Sci USA 97(23):12852\u201312857. https:\/\/doi.org\/10.1073\/pnas.220232997","journal-title":"Proc Natl Acad Sci USA"},{"key":"9176_CR89","doi-asserted-by":"publisher","unstructured":"[89] Zhou Z, Zhu G, Hariri AR, Enoch MA, Scott D, Sinha R, Virkkunen M, Mash DC, Lipsky RH, Hu XZ, Hodgkinson CA, Xu K, Buzas B, Yuan Q, Shen PH, Ferrell RE, Manuck SB, Brown SM, Hauger RL, Stohler CS, \u2026, Goldman D (2008). Genetic variation in human NPY expression affects stress response and emotion. Nature 452(7190):997-1001 https:\/\/doi.org\/10.1038\/nature06858","DOI":"10.1038\/nature06858"},{"issue":"2","key":"9176_CR90","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/s0022-3956(03)00101-8","volume":"38","author":"M Heilig","year":"2004","unstructured":"Heilig M, Zachrisson O, Thorsell A, Ehnvall A, Mottagui-Tabar S, Sj\u00f6gren M, Asberg M, Ekman R, Wahlestedt C, Agren H (2004) Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism. J Psychiatr Res 38(2):113\u2013121. https:\/\/doi.org\/10.1016\/s0022-3956(03)00101-8","journal-title":"J Psychiatr Res"},{"key":"9176_CR91","doi-asserted-by":"publisher","first-page":"580378","DOI":"10.3389\/fimmu.2020.580378","volume":"11","author":"WC Chen","year":"2020","unstructured":"Chen WC, Liu YB, Liu WF, Zhou YY, He HF, Lin S (2020) Neuropeptide Y Is an Immunomodulatory Factor: Direct and Indirect. Front Immunol 11:580378. https:\/\/doi.org\/10.3389\/fimmu.2020.580378","journal-title":"Front Immunol"},{"issue":"2","key":"9176_CR92","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/biof.1559","volume":"46","author":"M Obradovic","year":"2020","unstructured":"Obradovic M, Essack M, Zafirovic S, Sudar-Milovanovic E, Bajic VP, Van Neste C, Trpkovic A, Stanimirovic J, Bajic VB, Isenovic ER (2020) Redox control of vascular biology. Biofactors 46(2):246\u2013262. https:\/\/doi.org\/10.1002\/biof.1559","journal-title":"Biofactors"},{"key":"9176_CR93","doi-asserted-by":"publisher","first-page":"838434","DOI":"10.3389\/fendo.2022.838434","volume":"13","author":"ZT Anderson","year":"2022","unstructured":"Anderson ZT, Dawson AD, Slominski AT, Harris ML (2022) Current Insights Into the Role of Neuropeptide Y in Skin Physiology and Pathology. Front Endocrinol 13:838434. https:\/\/doi.org\/10.3389\/fendo.2022.838434","journal-title":"Front Endocrinol"},{"key":"9176_CR94","doi-asserted-by":"publisher","unstructured":"Zhang P, Miao J, Yu H, Yu H, Liu C, Zhao L, Yang P, Zhou T, Zhang B (2026) Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin. Cell S0092-8674(25)01492-8. Advance online publication https:\/\/doi.org\/10.1016\/j.cell.2025.12.043","DOI":"10.1016\/j.cell.2025.12.043"},{"issue":"12","key":"9176_CR95","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1038\/nrendo.2012.189","volume":"8","author":"VA Pavlov","year":"2012","unstructured":"Pavlov VA, Tracey KJ (2012) The vagus nerve and the inflammatory reflex\u2013linking immunity and metabolism. Nat Rev Endocrinol 8(12):743\u2013754. https:\/\/doi.org\/10.1038\/nrendo.2012.189","journal-title":"Nat Rev Endocrinol"},{"issue":"4","key":"9176_CR96","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1111\/joa.13122","volume":"236","author":"MF Butt","year":"2020","unstructured":"Butt MF, Albusoda A, Farmer AD, Aziz Q (2020) The anatomical basis for transcutaneous auricular vagus nerve stimulation. J Anat 236(4):588\u2013611. https:\/\/doi.org\/10.1111\/joa.13122","journal-title":"J Anat"},{"issue":"6","key":"9176_CR97","doi-asserted-by":"publisher","first-page":"3411","DOI":"10.3390\/ijms25063411","volume":"25","author":"S Luo","year":"2024","unstructured":"Luo S, Meng X, Ai J, Zhang Z, Dai Y, Yu X (2024) Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Monobenzone-Induced Vitiligo in Mice. Int J Mol Sci 25(6):3411. https:\/\/doi.org\/10.3390\/ijms25063411","journal-title":"Int J Mol Sci"},{"issue":"4","key":"9176_CR98","doi-asserted-by":"publisher","first-page":"312","DOI":"10.3892\/etm.2021.9743","volume":"21","author":"SL Said-Fernandez","year":"2021","unstructured":"Said-Fernandez SL, Sanchez-Dom\u00ednguez CN, Salinas-Santander MA, Martinez-Rodriguez HG, Kubelis-Lopez DE, Zapata-Salazar NA, Vazquez-Martinez OT, Wollina U, Lotti T, Ocampo-Candiani J (2021) Novel immunological and genetic factors associated with vitiligo: A review. Experimental therapeutic Med 21(4):312. https:\/\/doi.org\/10.3892\/etm.2021.9743","journal-title":"Experimental therapeutic Med"},{"issue":"2","key":"9176_CR99","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1017\/S1461145712000387","volume":"16","author":"S Manta","year":"2013","unstructured":"Manta S, El Mansari M, Debonnel G, Blier P (2013) Electrophysiological and neurochemical effects of long-term vagus nerve stimulation on the rat monoaminergic systems. Int J Neuropsychopharmacol 16(2):459\u2013470. https:\/\/doi.org\/10.1017\/S1461145712000387","journal-title":"Int J Neuropsychopharmacol"},{"issue":"4","key":"9176_CR100","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1139\/jpn.0936","volume":"34","author":"S Manta","year":"2009","unstructured":"Manta S, Dong J, Debonnel G, Blier P (2009) Enhancement of the function of rat serotonin and norepinephrine neurons by sustained vagus nerve stimulation. J psychiatry neuroscience: JPN 34(4):272\u2013280","journal-title":"J psychiatry neuroscience: JPN"},{"issue":"2","key":"9176_CR101","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.brs.2024.02.013","volume":"17","author":"L Skora","year":"2024","unstructured":"Skora L, Marzecov\u00e1 A, Jocham G (2024) Tonic and phasic transcutaneous auricular vagus nerve stimulation (taVNS) both evoke rapid and transient pupil dilation. Brain Stimul 17(2):233\u2013244. https:\/\/doi.org\/10.1016\/j.brs.2024.02.013","journal-title":"Brain Stimul"},{"issue":"1","key":"9176_CR102","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s42234-022-00094-y","volume":"8","author":"BW Badran","year":"2022","unstructured":"Badran BW, Huffman SM, Dancy M, Austelle CW, Bikson M, Kautz SA, George MS (2022) A pilot randomized controlled trial of supervised, at-home, self-administered transcutaneous auricular vagus nerve stimulation (taVNS) to manage long COVID symptoms. Bioelectronic Med 8(1):13. https:\/\/doi.org\/10.1186\/s42234-022-00094-y","journal-title":"Bioelectronic Med"},{"key":"9176_CR103","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3389\/fpsyt.2018.00020","volume":"9","author":"J Kong","year":"2018","unstructured":"Kong J, Fang J, Park J, Li S, Rong P (2018) Treating Depression with Transcutaneous Auricular Vagus Nerve Stimulation: State of the Art and Future Perspectives. Front Psychiatry 9:20. https:\/\/doi.org\/10.3389\/fpsyt.2018.00020","journal-title":"Front Psychiatry"},{"issue":"2","key":"9176_CR104","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s10286-023-00938-w","volume":"33","author":"D Soltani","year":"2023","unstructured":"Soltani D, Azizi B, Sima S, Tavakoli K, Hosseini Mohammadi NS, Vahabie AH, Akbarzadeh-Sherbaf K, Vasheghani-Farahani A (2023) A systematic review of the effects of transcutaneous auricular vagus nerve stimulation on baroreflex sensitivity and heart rate variability in healthy subjects. Clin Auton research: official J Clin Auton Res Soc 33(2):165\u2013189. https:\/\/doi.org\/10.1007\/s10286-023-00938-w","journal-title":"Clin Auton research: official J Clin Auton Res Soc"},{"issue":"6","key":"9176_CR105","doi-asserted-by":"publisher","first-page":"e14250","DOI":"10.1111\/psyp.14250","volume":"60","author":"S De Smet","year":"2023","unstructured":"De Smet S, Ottaviani C, Verkuil B, Kappen M, Baeken C, Vanderhasselt MA (2023) Effects of non-invasive vagus nerve stimulation on cognitive and autonomic correlates of perseverative cognition. Psychophysiology 60(6):e14250. https:\/\/doi.org\/10.1111\/psyp.14250","journal-title":"Psychophysiology"},{"issue":"16","key":"9176_CR106","doi-asserted-by":"publisher","first-page":"9274","DOI":"10.3390\/ijms23169274","volume":"23","author":"M Daniel","year":"2022","unstructured":"Daniel M, Bedoui Y, Vagner D, Raffray L, Ah-Pine F, Doray B, Gasque P (2022) Pathophysiology of Sepsis and Genesis of Septic Shock: The Critical Role of Mesenchymal Stem Cells (MSCs). Int J Mol Sci 23(16):9274. https:\/\/doi.org\/10.3390\/ijms23169274","journal-title":"Int J Mol Sci"},{"issue":"23","key":"9176_CR107","doi-asserted-by":"publisher","first-page":"11706","DOI":"10.3390\/ijms262311706","volume":"26","author":"N Kurhaluk","year":"2025","unstructured":"Kurhaluk N, Ko\u0142odziejska R, Kami\u0144ski P, Tkaczenko H (2025) Integrative Neuroimmune Role of the Parasympathetic Nervous System, Vagus Nerve and Gut Microbiota in Stress Modulation: A Narrative Review. Int J Mol Sci 26(23):11706. https:\/\/doi.org\/10.3390\/ijms262311706","journal-title":"Int J Mol Sci"},{"issue":"6","key":"9176_CR108","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1159\/000073036","volume":"72","author":"MR Namazi","year":"2003","unstructured":"Namazi MR (2003) Prescribing cyclic antidepressants for vitiligo patients: which agents are superior, which are not? Psychother Psychosom 72(6):361\u2013362. https:\/\/doi.org\/10.1159\/000073036","journal-title":"Psychother Psychosom"},{"issue":"1","key":"9176_CR109","doi-asserted-by":"publisher","first-page":"e13217","DOI":"10.1111\/pcmr.13217","volume":"38","author":"O Egriboz","year":"2025","unstructured":"Egriboz O, Fehrholz M, Tsutsumi M, Sousa M, Cheret J, Funk W, K\u00fcckelhaus M, Paus R, Kajiya K, Piccini I, Bertolini M (2025) The Melanocyte and Nerve Fiber Cross-Talk, Facilitated Also by Semaphorin-4A, Enhances UV-B-Induced Melanogenesis. Pigment cell melanoma Res 38(1):e13217. https:\/\/doi.org\/10.1111\/pcmr.13217","journal-title":"Pigment cell melanoma Res"},{"issue":"8","key":"9176_CR110","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s00403-024-03362-w","volume":"316","author":"C Cao","year":"2024","unstructured":"Cao C, Lei J, Zheng Y, Xu A, Zhou M (2024) The brain-skin axis in vitiligo. Arch Dermatol Res 316(8):607. https:\/\/doi.org\/10.1007\/s00403-024-03362-w","journal-title":"Arch Dermatol Res"},{"issue":"2","key":"9176_CR111","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.fmre.2022.08.016","volume":"4","author":"M Zhang","year":"2022","unstructured":"Zhang M, Liu T, Yang J (2022) Skin neuropathy and immunomodulation in diseases. Fundamental Res 4(2):218\u2013225. https:\/\/doi.org\/10.1016\/j.fmre.2022.08.016","journal-title":"Fundamental Res"},{"issue":"8","key":"9176_CR112","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1016\/j.immuni.2025.05.018","volume":"58","author":"X Yang","year":"2025","unstructured":"Yang X, Ding W, Lou F, Xu H, Sheng A, Sun Y, Cai X, Zhou M, Lin F, Jin R, Zheng X, Wang Z, Deng S, Xu Z, Zhang T, Cheng J, Zheng X, Xu A, Wang H (2025) Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8\u2009+\u2009T cell responses in vitiligo. Immunity 58(8):2086\u20132103e9. https:\/\/doi.org\/10.1016\/j.immuni.2025.05.018","journal-title":"Immunity"},{"key":"9176_CR113","doi-asserted-by":"publisher","unstructured":"Fen Peng S, Zhao X, Zhang S, Yanling LH (2022) Calcitonin gene-related peptide upregulates IL-17A and IL-22 in \u03b3\u03b4-T cells through the paracrine effect of langerhans cells on LC\/\u03b3\u03b4-T co-culture model. J Neuroimmunol 364. https:\/\/doi.org\/10.1016\/j.jneuroim.2021.577792","DOI":"10.1016\/j.jneuroim.2021.577792"},{"issue":"5","key":"9176_CR114","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1054\/npep.2000.0834","volume":"34","author":"A Ribeiro-da-Silva","year":"2000","unstructured":"Ribeiro-da-Silva A, H\u00f6kfelt T (2000) Neuroanatomical localisation of Substance P in the CNS and sensory neurons. Neuropeptides 34(5):256\u2013271. https:\/\/doi.org\/10.1054\/npep.2000.0834","journal-title":"Neuropeptides"},{"issue":"22","key":"9176_CR115","doi-asserted-by":"publisher","first-page":"4249","DOI":"10.1007\/s00018-016-2293-z","volume":"73","author":"A Mashaghi","year":"2016","unstructured":"Mashaghi A, Marmalidou A, Tehrani M, Grace PM, Pothoulakis C, Dana R (2016) Neuropeptide substance P and the immune response. Cell Mol Life Sci 73(22):4249\u20134264. https:\/\/doi.org\/10.1007\/s00018-016-2293-z","journal-title":"Cell Mol Life Sci"},{"issue":"7","key":"9176_CR116","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1210\/er.2009-0013","volume":"30","author":"IM Beck","year":"2009","unstructured":"Beck IM, Berghe V, Vermeulen W, Yamamoto L, Haegeman KR, G., De Bosscher K (2009) Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases. Endocr Rev 30(7):830\u2013882. https:\/\/doi.org\/10.1210\/er.2009-0013","journal-title":"Endocr Rev"},{"key":"9176_CR117","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.yfrne.2017.05.001","volume":"46","author":"SA Mandakh Bekhbat","year":"2017","unstructured":"Mandakh Bekhbat SA, Rowson, Gretchen N (2017) Neigh Checks and balances: the glucocorticoid receptor and NF\u0138B in good times and bad. Front Neuroendocrinol 46:15\u201331. https:\/\/doi.org\/10.1016\/j.yfrne.2017.05.001","journal-title":"Front Neuroendocrinol"},{"key":"9176_CR118","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.molimm.2023.07.007","volume":"161","author":"N Tang","year":"2023","unstructured":"Tang N, Liu X-T, Wen W-L, Liang T-S, Lv X-T, Li Q-L, Wang G-E, Wu Y-H (2023) Restraint stress promotes monobenzone-induced depigmentation in mice via the activation of glucocorticoid receptor\/macrophage migration inhibitory factor signaling pathway. Mol Immunol 161:33\u201343. https:\/\/doi.org\/10.1016\/j.molimm.2023.07.007","journal-title":"Mol Immunol"},{"issue":"5","key":"9176_CR119","doi-asserted-by":"publisher","first-page":"e98283","DOI":"10.1371\/journal.pone.0098283","volume":"9","author":"S Pang","year":"2014","unstructured":"Pang S, Wu H, Wang Q, Cai M, Shi W et al (2014) Chronic Stress Suppresses the Expression of Cutaneous Hypothalamic\u2013Pituitary\u2013Adrenocortical Axis Elements and Melanogenesis. PLoS ONE 9(5):e98283. https:\/\/doi.org\/10.1371\/journal.pone.0098283","journal-title":"PLoS ONE"},{"key":"9176_CR120","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1034\/j.1600-0749.13.s8.22.x","volume":"8","author":"M Tsatmali","year":"2000","unstructured":"Tsatmali M, Ancans J, Yukitake J, Thody AJ (2000) Skin POMC peptides: their actions at the human MC-1 receptor and roles in the tanning response. Pigment cell Res 13 Suppl 8:125\u2013129. https:\/\/doi.org\/10.1034\/j.1600-0749.13.s8.22.x","journal-title":"Pigment cell Res 13 Suppl"},{"issue":"3","key":"9176_CR121","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1530\/acta.0.1100313","volume":"110","author":"AJ Thody","year":"1985","unstructured":"Thody AJ, Fisher C, Kendal-Taylor P, Jones MT, Price J, Abraham RR (1985) The measurement and characterisation by high pressure liquid chromatography of immunoreactive alpha-melanocyte stimulating hormone in human plasma. Acta Endocrinol 110(3):313\u2013318. https:\/\/doi.org\/10.1530\/acta.0.1100313","journal-title":"Acta Endocrinol"},{"issue":"5","key":"9176_CR122","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/j.1600-0749.1997.tb00688.x","volume":"10","author":"K Wakamatsu","year":"1997","unstructured":"Wakamatsu K, Graham A, Cook D, Thody AJ (1997) Characterisation of ACTH peptides in human skin and their activation of the melanocortin-1 receptor. Pigment Cell Res 10(5):288\u2013297. https:\/\/doi.org\/10.1111\/j.1600-0749.1997.tb00688.x","journal-title":"Pigment Cell Res"},{"key":"9176_CR123","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/j.1600-0749.1998.tb00735.x","volume":"11","author":"AJ THODY","year":"1998","unstructured":"THODY AJ, GRAHAM A (1998) Does \u03b1-MSH Have a Role in Regulating Skin Pigmentation in Humans? Pigment Cell Res 11:265\u2013274. https:\/\/doi.org\/10.1111\/j.1600-0749.1998.tb00735.x","journal-title":"Pigment Cell Res"},{"issue":"3","key":"9176_CR124","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/j.1087-0024.2005.10108.x","volume":"10","author":"DJ Tobin","year":"2005","unstructured":"Tobin DJ, Kauser S (2005) Beta-endorphin: the forgotten hair follicle melanotropin. J Invest Dermatology Symp Proc 10(3):212\u2013216. https:\/\/doi.org\/10.1111\/j.1087-0024.2005.10108.x","journal-title":"J Invest dermatology Symp Proc"},{"issue":"6","key":"9176_CR125","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1046\/j.1523-1747.2003.12242.x","volume":"120","author":"S Kauser","year":"2003","unstructured":"Kauser S, Schallreuter KU, Thody AJ, Gummer C, Tobin DJ (2003) Regulation of human epidermal melanocyte biology by beta-endorphin. J Invest Dermatol 120(6):1073\u20131080. https:\/\/doi.org\/10.1046\/j.1523-1747.2003.12242.x","journal-title":"J Invest Dermatol"},{"key":"9176_CR126","doi-asserted-by":"publisher","unstructured":"Hall JM, Cruser D, Podawiltz A, Mummert DI, Jones H, Mummert ME (2012) Psychological Stress and the cutaneous immune response: roles of the HPA axis and the sympathetic nervous system in atopic dermatitis and psoriasis. Dermatol Res Pract 403908. https:\/\/doi.org\/10.1155\/2012\/403908","DOI":"10.1155\/2012\/403908"},{"issue":"Suppl","key":"9176_CR127","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1111\/j.1600-0625.2004.00254.x","volume":"13","author":"CC Zouboulis","year":"2004","unstructured":"Zouboulis CC, B\u00f6hm M (2004) Neuroendocrine regulation of sebocytes -- a pathogenetic link between stress and acne. Exp Dermatol 13(Suppl):431\u2013435. https:\/\/doi.org\/10.1111\/j.1600-0625.2004.00254.x","journal-title":"Exp Dermatol"},{"issue":"4","key":"9176_CR128","doi-asserted-by":"publisher","first-page":"E701","DOI":"10.1152\/ajpendo.00519.2004","volume":"288","author":"A Slominski","year":"2005","unstructured":"Slominski A, Zbytek B, Szczesniewski A, Semak I, Kaminski J, Sweatman T, Wortsman J (2005) CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH. Am J Physiol Endocrinol Metab 288(4):E701\u2013E706. https:\/\/doi.org\/10.1152\/ajpendo.00519.2004","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"9176_CR129","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/s0006-291x(02)00932-4","volume":"296","author":"MJ Hoogduijn","year":"2002","unstructured":"Hoogduijn MJ, Ancans J, Suzuki I, Estdale S, Thody AJ (2002) Melanin-concentrating hormone and its receptor are expressed and functional in human skin. Biochem Biophys Res Commun 296(3):698\u2013701. https:\/\/doi.org\/10.1016\/s0006-291x(02)00932-4","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"9176_CR130","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jdermsci.2010.08.004","volume":"60","author":"E Reimann","year":"2010","unstructured":"Reimann E, Kingo K, Karelson M, Salum T, Aunin E, Reemann P, Abram K, Vasar E, Silm H, K\u00f5ks S (2010) Analysis of the expression profile of CRH-POMC system genes in vitiligo skin biopsies. J Dermatol Sci 60(2):125\u2013128. https:\/\/doi.org\/10.1016\/j.jdermsci.2010.08.004","journal-title":"J Dermatol Sci"},{"issue":"9","key":"9176_CR131","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1007\/s00403-024-03363-9","volume":"316","author":"EMS Xerfan","year":"2024","unstructured":"Xerfan EMS, Facina AS, Tomimori J, Tufik S, Andersen ML (2024) The influence of phototherapy on circadian melatonin and sleep regulation and potential benefits of these pathways in the management of vitiligo: a narrative review: Vitiligo, phototherapy, sleep and melatonin. Arch Dermatol Res 316(9):632. https:\/\/doi.org\/10.1007\/s00403-024-03363-9","journal-title":"Arch Dermatol Res"},{"issue":"9","key":"9176_CR132","first-page":"42","volume":"12","author":"AB Lyons","year":"2019","unstructured":"Lyons AB, Moy L, Moy R, Tung R (2019) Circadian Rhythm and the Skin: A Review of the Literature. J Clin Aesthetic Dermatol 12(9):42\u201345","journal-title":"J Clin Aesthetic Dermatol"},{"issue":"1","key":"9176_CR133","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/2193-1801-2-158","volume":"2","author":"B Iyengar","year":"2013","unstructured":"Iyengar B (2013) The melanocyte photosensory system in the human skin. SpringerPlus 2(1):158. https:\/\/doi.org\/10.1186\/2193-1801-2-158","journal-title":"SpringerPlus"},{"issue":"6","key":"9176_CR134","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1159\/000014558","volume":"7","author":"B Iyengar","year":"1998","unstructured":"Iyengar B (1998) Photomodulation of the melanocyte cell cycle by indoleamines. Biol Signals Recept 7(6):345\u2013350","journal-title":"Biol Signals Recept"},{"issue":"1","key":"9176_CR135","doi-asserted-by":"publisher","first-page":"e13220","DOI":"10.1111\/pcmr.13220","volume":"38","author":"GE Bertolesi","year":"2025","unstructured":"Bertolesi GE, Debnath N, Heshami N, Bui R, Zadeh-Haghighi H, Simon C, McFarlane S (2025) Interplay of Light, Melatonin, and Circadian Genes in Skin Pigmentation Regulation. Pigment cell melanoma Res 38(1):e13220. https:\/\/doi.org\/10.1111\/pcmr.13220","journal-title":"Pigment cell melanoma Res"},{"issue":"8","key":"9176_CR136","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1096\/fasebj.10.8.8666165","volume":"10","author":"I Antol\u00edn","year":"1996","unstructured":"Antol\u00edn I, Rodr\u00edguez C, Sa\u00ednz RM, Mayo JC, Ur\u00eda H, Kotler ML, Rodr\u00edguez-Colunga MJ, Tolivia D, Men\u00e9ndez-Pel\u00e1ez A (1996) Neurohormone melatonin prevents cell damage: effect on gene expression for antioxidant enzymes. FASEB journal: official publication Federation Am Soc Experimental Biology 10(8):882\u2013890. https:\/\/doi.org\/10.1096\/fasebj.10.8.8666165","journal-title":"FASEB journal: official publication Federation Am Soc Experimental Biology"},{"issue":"2","key":"9176_CR137","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1600-079x.1998.tb00371.x","volume":"24","author":"M Kotler","year":"1998","unstructured":"Kotler M, Rodr\u00edguez C, S\u00e1inz RM, Antol\u00edn I, Men\u00e9ndez-Pel\u00e1ez A (1998) Melatonin increases gene expression for antioxidant enzymes in rat brain cortex. J Pineal Res 24(2):83\u201389. https:\/\/doi.org\/10.1111\/j.1600-079x.1998.tb00371.x","journal-title":"J Pineal Res"},{"issue":"3","key":"9176_CR138","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1600-079x.1995.tb00178.x","volume":"19","author":"MI Pablos","year":"1995","unstructured":"Pablos MI, Agapito MT, Gutierrez R, Recio JM, Reiter RJ, Barlow-Walden L, Acu\u00f1a-Castroviejo D, Menendez-Pelaez A (1995) Melatonin stimulates the activity of the detoxifying enzyme glutathione peroxidase in several tissues of chicks. J Pineal Res 19(3):111\u2013115. https:\/\/doi.org\/10.1111\/j.1600-079x.1995.tb00178.x","journal-title":"J Pineal Res"},{"issue":"5","key":"9176_CR139","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s00109-023-02301-y","volume":"101","author":"LP Ma","year":"2023","unstructured":"Ma LP, Liu MM, Liu F, Sun B, Wang SN, Chen J, Yu HJ, Yan J, Tian M, Gao L, Liu QJ (2023) Melatonin inhibits senescence-associated melanin pigmentation through the p53-TYR pathway in human primary melanocytes and the skin of C57BL\/6 J mice after UVB irradiation. J Mol Med 101(5):581\u2013593. https:\/\/doi.org\/10.1007\/s00109-023-02301-y","journal-title":"J Mol Med"},{"key":"9176_CR140","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/j.1600-0625.2007.00666_5.x","volume":"17","author":"A Slominski","year":"2008","unstructured":"Slominski A, Zmijewski M, Paus R (2008) Viewpoint 4: melatonin hypothesis on the vitiligo pathogenesis. Exp Dermatol 17:149\u2013152. https:\/\/doi.org\/10.1111\/j.1600-0625.2007.00666_5.x","journal-title":"Exp Dermatol"},{"issue":"1","key":"9176_CR141","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/j.1600-079X.2006.00407.x","volume":"42","author":"DX Tan","year":"2007","unstructured":"Tan DX, Manchester LC, Terron MP, Flores LJ, Reiter RJ (2007) One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 42(1):28\u201342. https:\/\/doi.org\/10.1111\/j.1600-079X.2006.00407.x","journal-title":"J Pineal Res"},{"issue":"9","key":"9176_CR142","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1096\/fj.05-5227fje","volume":"20","author":"TW Fischer","year":"2006","unstructured":"Fischer TW, Sweatman TW, Semak I, Sayre RM, Wortsman J, Slominski A (2006) Constitutive and UV-induced metabolism of melatonin in keratinocytes and cell-free systems. FASEB journal: official publication Federation Am Soc Experimental Biology 20(9):1564\u20131566. https:\/\/doi.org\/10.1096\/fj.05-5227fje","journal-title":"FASEB journal: official publication Federation Am Soc Experimental Biology"},{"issue":"2","key":"9176_CR143","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1096\/fj.04-2079rev","volume":"19","author":"A Slominski","year":"2005","unstructured":"Slominski A, Wortsman J, Tobin DJ (2005) The cutaneous serotoninergic\/melatoninergic system: securing a place under the sun. FASEB journal: official publication Federation Am Soc Experimental Biology 19(2):176\u2013194. https:\/\/doi.org\/10.1096\/fj.04-2079rev","journal-title":"FASEB journal: official publication Federation Am Soc Experimental Biology"},{"issue":"9","key":"9176_CR144","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1177\/014107688908200911","volume":"82","author":"A Slominski","year":"1989","unstructured":"Slominski A, Paus R, Bomirski A (1989) Hypothesis: possible role for the melatonin receptor in vitiligo: discussion paper. J R Soc Med 82(9):539\u2013541. https:\/\/doi.org\/10.1177\/014107688908200911","journal-title":"J R Soc Med"},{"issue":"1","key":"9176_CR145","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00424-011-1044-0","volume":"463","author":"L Besedovsky","year":"2012","unstructured":"Besedovsky L, Lange T, Born J (2012) Sleep and immune function. Pflug Arch: Eur J Physiol 463(1):121\u2013137. https:\/\/doi.org\/10.1007\/s00424-011-1044-0","journal-title":"Pflug Arch: Eur J Physiol"},{"key":"9176_CR146","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1146\/annurev-immunol-100919-023531","volume":"38","author":"ML Frisoli","year":"2020","unstructured":"Frisoli ML, Essien K, Harris JE (2020) Vitiligo: Mechanisms of Pathogenesis and Treatment. Annu Rev Immunol 38:621\u2013648. https:\/\/doi.org\/10.1146\/annurev-immunol-100919-023531","journal-title":"Annu Rev Immunol"},{"issue":"6","key":"9176_CR147","doi-asserted-by":"publisher","first-page":"671","DOI":"10.33549\/physiolres.931236","volume":"56","author":"L Paulis","year":"2007","unstructured":"Paulis L, Simko F (2007) Blood pressure modulation and cardiovascular protection by melatonin: potential mechanisms behind. Physiol Res 56(6):671\u2013684. https:\/\/doi.org\/10.33549\/physiolres.931236","journal-title":"Physiol Res"},{"issue":"11","key":"9176_CR148","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1038\/s41440-019-0318-3","volume":"42","author":"F Simko","year":"2019","unstructured":"Simko F, Reiter RJ, Paulis L (2019) Melatonin as a rational alternative in the conservative treatment of resistant hypertension. Hypertens research: official J Japanese Soc Hypertens 42(11):1828\u20131831. https:\/\/doi.org\/10.1038\/s41440-019-0318-3","journal-title":"Hypertens research: official J Japanese Soc Hypertens"},{"issue":"24","key":"9176_CR149","doi-asserted-by":"publisher","first-page":"16187","DOI":"10.3390\/ijms232416187","volume":"23","author":"K Repova","year":"2022","unstructured":"Repova K, Baka T, Krajcirovicova K, Stanko P, Aziriova S, Reiter RJ, Simko F (2022) Melatonin as a Potential Approach to Anxiety Treatment. Int J Mol Sci 23(24):16187. https:\/\/doi.org\/10.3390\/ijms232416187","journal-title":"Int J Mol Sci"},{"key":"9176_CR150","doi-asserted-by":"publisher","unstructured":"Seneschal J, Speeckaert R, Ta\u00efeb A, Wolkerstorfer A, Passeron T, Pandya AG, Lim HW, Ezzedine K, Zhou Y, Xiang F, Thng S, Tanemura A, Suzuki T, Rosmarin D, Rodrigues M, Raboobee N, Pliszewski G, Parsad D, Oiso N, Monteiro P\u2026, van Geel N (2023) Worldwide expert recommendations for the diagnosis and management of vitiligo: position statement from the international vitiligo task force-part 2: specific treatment recommendations. J Eur Acad Dermatol Venereol: JEADV 37(11): 2185\u20132195 https:\/\/doi.org\/10.1111\/jdv.19450","DOI":"10.1111\/jdv.19450"},{"issue":"1","key":"9176_CR151","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3390\/ijms20010080","volume":"20","author":"L Liu","year":"2018","unstructured":"Liu L, Fu M, Pei S, Zhou L, Shang J (2018) R-Fluoxetine Increases Melanin Synthesis Through a 5-HT1A\/2A Receptor and p38 MAPK Signaling Pathways. Int J Mol Sci 20(1):80. https:\/\/doi.org\/10.3390\/ijms20010080","journal-title":"Int J Mol Sci"},{"key":"9176_CR152","doi-asserted-by":"publisher","first-page":"571459","DOI":"10.3389\/fphar.2020.571459","volume":"11","author":"J Sharifi-Rad","year":"2020","unstructured":"Sharifi-Rad J, Kamiloglu S, Yeskaliyeva B, Beyatli A, Alfred MA, Salehi B, Calina D, Docea AO, Imran M, Kumar A, Romero-Rom\u00e1n NV, Maroyi ME, A., Martorell M (2020) Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action. Front Pharmacol 11:571459. https:\/\/doi.org\/10.3389\/fphar.2020.571459","journal-title":"Front Pharmacol"},{"key":"9176_CR153","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.freeradbiomed.2018.10.421","volume":"129","author":"J Ma","year":"2018","unstructured":"Ma J, Li S, Zhu L, Guo S, Yi X, Cui T, He Y, Chang Y, Liu B, Li C, Jian Z (2018) Baicalein protects human vitiligo melanocytes from oxidative stress through activation of NF-E2-related factor2 (Nrf2) signaling pathway. Free Radic Biol Med 129:492\u2013503. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.10.421","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"9176_CR154","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1248\/bpb.34.253","volume":"34","author":"Z Xiong","year":"2011","unstructured":"Xiong Z, Jiang B, Wu PF, Tian J, Shi LL, Gu J, Hu ZL, Fu H, Wang F, Chen JG (2011) Antidepressant effects of a plant-derived flavonoid baicalein involving extracellular signal-regulated kinases cascade. Biol Pharm Bull 34(2):253\u2013259. https:\/\/doi.org\/10.1248\/bpb.34.253","journal-title":"Biol Pharm Bull"},{"issue":"3","key":"9176_CR155","first-page":"116","volume":"39","author":"S Takekoshi","year":"2014","unstructured":"Takekoshi S, Nagata H, Kitatani K (2014) Flavonoids enhance melanogenesis in human melanoma cells. Tokai J Exp Clin Med 39(3):116\u2013121","journal-title":"Tokai J Exp Clin Med"},{"issue":"1","key":"9176_CR156","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1046\/j.1600-0749.2003.00113.x","volume":"17","author":"H Nagata","year":"2004","unstructured":"Nagata H, Takekoshi S, Takeyama R, Homma T, Yoshiyuki Osamura R (2004) Quercetin enhances melanogenesis by increasing the activity and synthesis of tyrosinase in human melanoma cells and in normal human melanocytes. Pigment Cell Res 17(1):66\u201373. https:\/\/doi.org\/10.1046\/j.1600-0749.2003.00113.x","journal-title":"Pigment Cell Res"},{"issue":"6","key":"9176_CR157","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1002\/mnfr.201500822","volume":"60","author":"F Liu-Smith","year":"2016","unstructured":"Liu-Smith F, Meyskens FL (2016) Molecular mechanisms of flavonoids in melanin synthesis and the potential for the prevention and treatment of melanoma. Mol Nutr Food Res 60(6):1264\u20131274. https:\/\/doi.org\/10.1002\/mnfr.201500822","journal-title":"Mol Nutr Food Res"},{"issue":"5","key":"9176_CR158","doi-asserted-by":"publisher","first-page":"795","DOI":"10.33549\/physiolres.933776","volume":"67","author":"N Samad","year":"2018","unstructured":"Samad N, Saleem A, Yasmin F, Shehzad MA (2018) Quercetin protects against stress-induced anxiety- and depression-like behavior and improves memory in male mice. Physiol Res 67(5):795\u2013808. https:\/\/doi.org\/10.33549\/physiolres.933776","journal-title":"Physiol Res"},{"key":"9176_CR159","doi-asserted-by":"publisher","first-page":"147661","DOI":"10.1016\/j.brainres.2021.147661","volume":"1772","author":"Y Guan","year":"2021","unstructured":"Guan Y, Wang J, Wu X, Song L, Wang Y, Gong M, Li B (2021) Quercetin reverses chronic unpredictable mild stress-induced depression-like behavior in vivo by involving nuclear factor-E2-related factor 2. Brain Res 1772:147661. https:\/\/doi.org\/10.1016\/j.brainres.2021.147661","journal-title":"Brain Res"},{"issue":"4","key":"9176_CR160","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.jphs.2021.08.009","volume":"147","author":"H Tang","year":"2021","unstructured":"Tang H, Yang L, Wu L, Wang H, Chen K, Wu H, Li Y (2021) Kaempferol, the melanogenic component of Sanguisorba officinalis, enhances dendricity and melanosome maturation\/transport in melanocytes. J Pharmacol Sci 147(4):348\u2013357. https:\/\/doi.org\/10.1016\/j.jphs.2021.08.009","journal-title":"J Pharmacol Sci"},{"issue":"2","key":"9176_CR161","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/s11011-019-0389-5","volume":"34","author":"W Gao","year":"2019","unstructured":"Gao W, Wang W, Peng Y, Deng Z (2019) Antidepressive effects of kaempferol mediated by reduction of oxidative stress, proinflammatory cytokines and up-regulation of AKT\/\u03b2-catenin cascade. Metab Brain Dis 34(2):485\u2013494. https:\/\/doi.org\/10.1007\/s11011-019-0389-5","journal-title":"Metab Brain Dis"},{"issue":"20","key":"9176_CR162","doi-asserted-by":"publisher","first-page":"4683","DOI":"10.3390\/molecules25204683","volume":"25","author":"H Ahmad","year":"2020","unstructured":"Ahmad H, Rauf K, Zada W, McCarthy M, Abbas G, Anwar F, Shah AJ (2020) Kaempferol Facilitated Extinction Learning in Contextual Fear Conditioned Rats via Inhibition of Fatty-Acid Amide Hydrolase. Molecules 25(20):4683. https:\/\/doi.org\/10.3390\/molecules25204683","journal-title":"Molecules"},{"key":"9176_CR163","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.fitote.2014.08.007","volume":"99","author":"Y Zhu","year":"2014","unstructured":"Zhu Y, Wang S, Lin F, Li Q, Xu A (2014) The therapeutic effects of EGCG on vitiligo. Fitoterapia 99:243\u2013251. https:\/\/doi.org\/10.1016\/j.fitote.2014.08.007","journal-title":"Fitoterapia"},{"issue":"11","key":"9176_CR164","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1248\/bpb.b15-00331","volume":"38","author":"W Ning","year":"2015","unstructured":"Ning W, Wang S, Dong X, Liu D, Fu L, Jin R, Xu A (2015) Epigallocatechin-3-gallate (EGCG) Suppresses the Trafficking of Lymphocytes to Epidermal Melanocytes via Inhibition of JAK2: Its Implication for Vitiligo Treatment. Biol Pharm Bull 38(11):1700\u20131706. https:\/\/doi.org\/10.1248\/bpb.b15-00331","journal-title":"Biol Pharm Bull"},{"issue":"10","key":"9176_CR165","doi-asserted-by":"publisher","first-page":"8780","DOI":"10.1039\/d0fo00524j","volume":"11","author":"G Li","year":"2020","unstructured":"Li G, Yang J, Wang X, Zhou C, Zheng X, Lin W (2020) Effects of EGCG on depression-related behavior and serotonin concentration in a rat model of chronic unpredictable mild stress. Food Funct 11(10):8780\u20138787. https:\/\/doi.org\/10.1039\/d0fo00524j","journal-title":"Food Funct"},{"issue":"6","key":"9176_CR166","doi-asserted-by":"publisher","first-page":"e01633","DOI":"10.1002\/brb3.1633","volume":"10","author":"J Wang","year":"2020","unstructured":"Wang J, Li P, Qin T, Sun D, Zhao X, Zhang B (2020) Protective effect of epigallocatechin-3-gallate against neuroinflammation and anxiety-like behavior in a rat model of myocardial infarction. Brain Behav 10(6):e01633. https:\/\/doi.org\/10.1002\/brb3.1633","journal-title":"Brain Behav"},{"issue":"1","key":"9176_CR167","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.brainres.2006.06.062","volume":"1110","author":"M Vignes","year":"2006","unstructured":"Vignes M, Maurice T, Lant\u00e9 F, Nedjar M, Thethi K, Guiramand J, R\u00e9casens M (2006) Anxiolytic properties of green tea polyphenol (-)-epigallocatechin gallate (EGCG). Brain Res 1110(1):102\u2013115. https:\/\/doi.org\/10.1016\/j.brainres.2006.06.062","journal-title":"Brain Res"},{"issue":"2","key":"9176_CR168","doi-asserted-by":"publisher","first-page":"116","DOI":"10.2174\/1566524019666191016150757","volume":"20","author":"M Ashrafizadeh","year":"2020","unstructured":"Ashrafizadeh M, Ahmadi Z, Mohammadinejad R, Farkhondeh T, Samarghandian S (2020) Curcumin Activates the Nrf2 Pathway and Induces Cellular Protection Against Oxidative Injury. Curr Mol Med 20(2):116\u2013133. https:\/\/doi.org\/10.2174\/1566524019666191016150757","journal-title":"Curr Mol Med"},{"key":"9176_CR169","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.nutres.2020.01.005","volume":"75,","author":"D\u039d Skyvalidas","year":"2020","unstructured":"Skyvalidas D\u039d, Mavropoulos A, Tsiogkas S, Dardiotis E, Liaskos C, Mamuris Z, Roussaki-Schulze A, Sakkas LI, Zafiriou E, Bogdanos DP (2020) Curcumin mediates attenuation of pro-inflammatory interferon \u03b3 and interleukin 17 cytokine responses in psoriatic disease, strengthening its role as a dietary immunosuppressant. Nutr Res (New York) 75:95\u2013108. https:\/\/doi.org\/10.1016\/j.nutres.2020.01.005","journal-title":"Nutr Res (New York)"},{"key":"9176_CR170","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.jad.2020.09.091","volume":"278","author":"M Sadeghian","year":"2021","unstructured":"Sadeghian M, Rahmani S, Jamialahmadi T, Johnston TP, Sahebkar A (2021) The effect of oral curcumin supplementation on health-related quality of life: A systematic review and meta-analysis of randomized controlled trials. J Affect Disord 278:627\u2013636. https:\/\/doi.org\/10.1016\/j.jad.2020.09.091","journal-title":"J Affect Disord"},{"issue":"1","key":"9176_CR171","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3892\/ijmm.2019.4200","volume":"44","author":"K Mou","year":"2019","unstructured":"Mou K, Pan W, Han D, Wen X, Cao F, Miao Y, Li P (2019) Glycyrrhizin protects human melanocytes from H2O2-induced oxidative damage via the Nrf2-dependent induction of HO-1. Int J Mol Med 44(1):253\u2013261. https:\/\/doi.org\/10.3892\/ijmm.2019.4200","journal-title":"Int J Mol Med"},{"issue":"3","key":"9176_CR172","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/emm.2001.23","volume":"33","author":"GD Jung","year":"2001","unstructured":"Jung GD, Yang JY, Song ES, Par JW (2001) Stimulation of melanogenesis by glycyrrhizin in B16 melanoma cells. Exp Mol Med 33(3):131\u2013135. https:\/\/doi.org\/10.1038\/emm.2001.23","journal-title":"Exp Mol Med"},{"issue":"2","key":"9176_CR173","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/j.0022-202X.2004.23606.x","volume":"124","author":"J Lee","year":"2005","unstructured":"Lee J, Jung E, Park J, Jung K, Park E, Kim J, Hong S, Park J, Park S, Lee S, Park D (2005) Glycyrrhizin induces melanogenesis by elevating a cAMP level in b16 melanoma cells. J Invest Dermatol 124(2):405\u2013411. https:\/\/doi.org\/10.1111\/j.0022-202X.2004.23606.x","journal-title":"J Invest Dermatol"},{"issue":"8","key":"9176_CR174","doi-asserted-by":"publisher","first-page":"e5354","DOI":"10.1590\/1414-431X20165354","volume":"49","author":"KH Mou","year":"2016","unstructured":"Mou KH, Han D, Liu WL, Li P (2016) Combination therapy of orally administered glycyrrhizin and UVB improved active-stage generalized vitiligo. Brazilian J Med Biol Res = Revista brasileira de pesquisas medicas e biologica 49(8):e5354. https:\/\/doi.org\/10.1590\/1414-431X20165354","journal-title":"Brazilian J Med Biol Res = Revista brasileira de pesquisas medicas e biologica"},{"key":"9176_CR175","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.pnpbp.2019.02.005","volume":"92","author":"K Hisaoka-Nakashima","year":"2019","unstructured":"Hisaoka-Nakashima K, Tomimura Y, Yoshii T, Ohata K, Takada N, Zhang FF, Nakamura Y, Liu K, Wake H, Nishibori M, Nakata Y, Morioka N (2019) High-mobility group box 1-mediated microglial activation induces anxiodepressive-like behaviors in mice with neuropathic pain. Prog Neuro-psychopharmacol Biol Psychiatry 92:347\u2013362. https:\/\/doi.org\/10.1016\/j.pnpbp.2019.02.005","journal-title":"Prog Neuro-psychopharmacol Biol Psychiatry"},{"key":"9176_CR176","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jpsychires.2015.02.016","volume":"64","author":"TY Wu","year":"2015","unstructured":"Wu TY, Liu L, Zhang W, Zhang Y, Liu YZ, Shen XL, Gong H, Yang YY, Bi XY, Jiang CL, Wang YX (2015) High-mobility group box-1 was released actively and involved in LPS induced depressive-like behavior. J Psychiatr Res 64:99\u2013106. https:\/\/doi.org\/10.1016\/j.jpsychires.2015.02.016","journal-title":"J Psychiatr Res"},{"issue":"7","key":"9176_CR177","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s00403-016-1675-2","volume":"308","author":"M Vaccaro","year":"2016","unstructured":"Vaccaro M, Cicero F, Mannucci C, Calapai G, Spatari G, Barbuzza O, Cannav\u00f2 SP, Gangemi S (2016) IL-33 circulating serum levels are increased in patients with non-segmental generalized vitiligo. Arch Dermatol Res 308(7):527\u2013530. https:\/\/doi.org\/10.1007\/s00403-016-1675-2","journal-title":"Arch Dermatol Res"},{"key":"9176_CR178","doi-asserted-by":"crossref","unstructured":"Stokes JH, Pillsbury DH (1930) The effect on the skin of emotional and nervous states: theoretical and practical consideration of a gastrointestinal mechanism. Arch Derm Syphilol","DOI":"10.1001\/archderm.1930.01440180008002"},{"issue":"5","key":"9176_CR179","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1111\/j.1600-0625.2009.01060.x","volume":"19","author":"P Arck","year":"2010","unstructured":"Arck P, Handjiski B, Hagen E, Pincus M, Bruenahl C, Bienenstock J, Paus R (2010) Is there a \u2018gut-brain-skin axis\u2019? Exp Dermatol 19(5):401\u2013405. https:\/\/doi.org\/10.1111\/j.1600-0625.2009.01060.x","journal-title":"Exp Dermatol"},{"issue":"2","key":"9176_CR180","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3920\/BM2012.0060","volume":"5","author":"W Bowe","year":"2014","unstructured":"Bowe W, Patel NB, Logan AC (2014) Acne vulgaris, probiotics and the gut-brain-skin axis: from anecdote to translational medicine. Beneficial microbes 5(2):185\u2013199. https:\/\/doi.org\/10.3920\/BM2012.0060","journal-title":"Beneficial microbes"},{"issue":"1","key":"9176_CR181","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.it.2005.10.002","volume":"27","author":"R Paus","year":"2006","unstructured":"Paus R, Theoharides TC, Arck PC (2006) Neuroimmunoendocrine circuitry of the \u2018brain-skin connection\u2019. Trends Immunol 27(1):32\u201339. https:\/\/doi.org\/10.1016\/j.it.2005.10.002","journal-title":"Trends Immunol"},{"issue":"2","key":"9176_CR182","first-page":"203","volume":"28","author":"M Carabotti","year":"2015","unstructured":"Carabotti M, Scirocco A, Maselli MA, Severi C (2015) The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Annals Gastroenterol 28(2):203\u2013209","journal-title":"Annals Gastroenterol"},{"issue":"1","key":"9176_CR183","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1186\/s12866-023-03020-7","volume":"23","author":"M Luan","year":"2023","unstructured":"Luan M, Niu M, Yang P, Han D, Zhang Y, Li W, He Q, Zhao Y, Mao B, Chen J, Mou K, Li P (2023) Metagenomic sequencing reveals altered gut microbial compositions and gene functions in patients with non-segmental vitiligo. BMC Microbiol 23(1):265. https:\/\/doi.org\/10.1186\/s12866-023-03020-7","journal-title":"BMC Microbiol"},{"issue":"5","key":"9176_CR184","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1080\/19490976.2020.1747329","volume":"11","author":"Z Dan","year":"2020","unstructured":"Dan Z, Mao X, Liu Q, Guo M, Zhuang Y, Liu Z, Chen K, Chen J, Xu R, Tang J, Qin L, Gu B, Liu K, Su C, Zhang F, Xia Y, Hu Z, Liu X (2020) Altered gut microbial profile is associated with abnormal metabolism activity of Autism Spectrum Disorder. Gut Microbes 11(5):1246\u20131267. https:\/\/doi.org\/10.1080\/19490976.2020.1747329","journal-title":"Gut Microbes"},{"key":"9176_CR185","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/s41586-025-09120-w","volume":"643","author":"Z White","year":"2025","unstructured":"White Z, Cabrera I, Mei L et al (2025) Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation. Nature 643:509\u2013518. https:\/\/doi.org\/10.1038\/s41586-025-09120-w","journal-title":"Nature"},{"issue":"7812","key":"9176_CR186","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/s41586-020-2352-3","volume":"582","author":"J Lee","year":"2020","unstructured":"Lee J, Rabbani CC, Gao H, Steinhart MR, Woodruff BM, Pflum ZE, Kim A, Heller S, Liu Y, Shipchandler TZ, Koehler KR (2020) Hair-bearing human skin generated entirely from pluripotent stem cells. Nature 582(7812):399\u2013404. https:\/\/doi.org\/10.1038\/s41586-020-2352-3","journal-title":"Nature"}],"container-title":["Clinical Reviews in Allergy & Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-026-09176-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12016-026-09176-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12016-026-09176-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T07:03:47Z","timestamp":1782198227000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12016-026-09176-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":186,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["9176"],"URL":"https:\/\/doi.org\/10.1007\/s12016-026-09176-0","relation":{},"ISSN":["1559-0267"],"issn-type":[{"value":"1559-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,22]]},"assertion":[{"value":"29 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not necessary","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Declaration"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"53"}}