{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:06:18Z","timestamp":1791396378634,"version":"4.3.3"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T00:00:00Z","timestamp":1203465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuromol Med"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1007\/s12017-008-8030-5","type":"journal-article","created":{"date-parts":[[2008,2,19]],"date-time":"2008-02-19T14:33:30Z","timestamp":1203431610000},"page":"108-117","source":"Crossref","is-referenced-by-count":50,"title":["Physical Activity and Neuroprotection in Amyotrophic Lateral Sclerosis"],"prefix":"10.1007","volume":"10","author":[{"given":"Mary E.","family":"McCrate","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Kaspar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,2,20]]},"reference":[{"key":"8030_CR1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","volume":"7","author":"N. J. Abbott","year":"2006","unstructured":"Abbott, N. J., Ronnback, L., & Hansson, E. (2006). Astrocyte-endothelial interactions at the blood-brain barrier. Nature Reviews Neuroscience, 7, 41\u201353.","journal-title":"Nature Reviews Neuroscience"},{"key":"8030_CR2","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0003-9993(97)90073-3","volume":"78","author":"J. C. Agre","year":"1997","unstructured":"Agre, J. C., Rodriquez, A. A., & Franke, T. M. (1997). Strength, endurance, and work capacity after muscle strengthening exercise in postpolio subjects. Archive of Physics Medical Rehabilitation, 78, 681\u2013686.","journal-title":"Archive of Physics Medical Rehabilitation"},{"key":"8030_CR3","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1212\/WNL.46.5.1244","volume":"46","author":"ALS CNS Treatment Group","year":"1996","unstructured":"ALS CNS Treatment Group. (1996). A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. ALS CNTF Treatment Study Group. Neurology, 46, 1244\u20131249.","journal-title":"Neurology"},{"key":"8030_CR4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jns.2007.06.021","volume":"262","author":"C. Armon","year":"2007","unstructured":"Armon, C. (2007). Sports and trauma in amyotrophic lateral sclerosis revisited. Journal of the Neurological Sciences, 262, 45\u201353.","journal-title":"Journal of the Neurological Sciences"},{"key":"8030_CR5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nature02544","volume":"429","author":"M. Azzouz","year":"2004","unstructured":"Azzouz, M., Ralph, G. S., Storkebaum, E., et\u00a0al. (2004). VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model. Nature, 429, 413\u2013417.","journal-title":"Nature"},{"key":"8030_CR6","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1212\/WNL.52.7.1427","volume":"52","author":"BDNF Study Group","year":"1999","unstructured":"BDNF Study Group (1999). A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III). Neurology, 52, 1427\u20131433.","journal-title":"Neurology"},{"key":"8030_CR7","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1212\/01.wnl.0000264418.92308.a4","volume":"68","author":"V. D. Bello-Haas","year":"2007","unstructured":"Bello-Haas, V. D., Florence, J. M., Kloos, A. D., et\u00a0al. (2007). A randomized controlled trial of resistance exercise in individuals with ALS. Neurology, 68, 2003\u20132007.","journal-title":"Neurology"},{"key":"8030_CR8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuron.2006.09.018","volume":"52","author":"S. Boillee","year":"2006","unstructured":"Boillee, S., Vande Velde, C., & Cleveland, D. W. (2006a). ALS: a disease of motor neurons and their nonneuronal neighbors. Neuron, 52, 39\u201359.","journal-title":"Neuron"},{"key":"8030_CR9","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1126\/science.1123511","volume":"312","author":"S. Boillee","year":"2006","unstructured":"Boillee, S., Yamanaka, K., Lobsiger, C. S., et\u00a0al. (2006b). Onset and progression in inherited ALS determined by motor neurons and microglia. Science, 312, 1389\u20131392.","journal-title":"Science"},{"key":"8030_CR10","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0896-6273(00)80272-X","volume":"18","author":"L. I. Bruijn","year":"1997","unstructured":"Bruijn, L. I., Becher, M. W., Lee, M. K., et\u00a0al. (1997). ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron, 18, 327\u2013338.","journal-title":"Neuron"},{"key":"8030_CR11","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1146\/annurev.neuro.27.070203.144244","volume":"27","author":"L. I. Bruijn","year":"2004","unstructured":"Bruijn, L. I., Miller, T. M., & Cleveland, D. W. (2004). Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annual Review of Neuroscience, 27, 723\u2013749.","journal-title":"Annual Review of Neuroscience"},{"key":"8030_CR12","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1523\/JNEUROSCI.20-08-02926.2000","volume":"20","author":"E. Carro","year":"2000","unstructured":"Carro, E., Nunez, A., Busiguina, S., & Torres-Aleman, I. (2000). Circulating insulin-like growth factor I mediates effects of exercise on the brain. Journal of Neurosciences, 20, 2926\u20132933.","journal-title":"Journal of Neurosciences"},{"key":"8030_CR13","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1523\/JNEUROSCI.21-15-05678.2001","volume":"21","author":"E. Carro","year":"2001","unstructured":"Carro, E., Trejo, J. L., Busiguina, S., & Torres-Aleman, I. (2001). Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy. Journal of Neurosciences, 21, 5678\u20135684.","journal-title":"Journal of Neurosciences"},{"key":"8030_CR14","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/nm1202-793","volume":"8","author":"E. Carro","year":"2002","unstructured":"Carro, E., Trejo, J. L., Gomez-Isla, T., LeRoith, D., & Torres-Aleman, I. (2002). Serum insulin-like growth factor I regulates brain amyloid-beta levels. Nature Medicine, 8, 1390\u20131397.","journal-title":"Nature Medicine"},{"key":"8030_CR15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1385\/MN:27:2:153","volume":"27","author":"E. Carro","year":"2003","unstructured":"Carro, E., Trejo, J. L., Nunez, A., & Torres-Aleman, I. (2003). Brain repair and neuroprotection by serum insulin-like growth factor I. Molecular Neurobiology, 27, 153\u2013162.","journal-title":"Molecular Neurobiology"},{"key":"8030_CR16","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/mus.10327","volume":"27","author":"K. M. Chan","year":"2003","unstructured":"Chan, K. M., Amirjani, N., Sumrain, M., Clarke, A., & Strohschein, F. J. (2003). Randomized controlled trial of strength training in post-polio patients. Muscle Nerve, 27, 332\u2013338.","journal-title":"Muscle Nerve"},{"key":"8030_CR17","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/brain\/awh373","volume":"128","author":"A. Chio","year":"2005","unstructured":"Chio, A., Benzi, G., Dossena, M., Mutani, R., & Mora, G. (2005). Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players. Brain, 128, 472\u2013476.","journal-title":"Brain"},{"key":"8030_CR18","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35097565","volume":"2","author":"D. W. Cleveland","year":"2001","unstructured":"Cleveland, D. W., & Rothstein, J. D. (2001). From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nature Reviews Neuroscience, 2, 806\u2013819.","journal-title":"Nature Reviews Neuroscience"},{"key":"8030_CR19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0166-2236(02)02143-4","volume":"25","author":"C. W. Cotman","year":"2002","unstructured":"Cotman, C. W., & Berchtold, N. C. (2002). Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neuroscience, 25, 295\u2013301.","journal-title":"Trends Neuroscience"},{"key":"8030_CR20","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/ana.410410212","volume":"41","author":"M. E. Cudkowicz","year":"1997","unstructured":"Cudkowicz, M. E., McKenna-Yasek, D., Sapp, P. E., et\u00a0al. (1997). Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis. Annual of Neurology, 41, 210\u2013221.","journal-title":"Annual of Neurology"},{"key":"8030_CR21","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2174\/1567202043361875","volume":"1","author":"Y. H. Ding","year":"2004","unstructured":"Ding, Y. H., Luan, X. D., Li, J., et\u00a0al. (2004). Exercise-induced overexpression of angiogenic factors and reduction of ischemia\/reperfusion injury in stroke. Current Neurovascular Research, 1, 411\u2013420.","journal-title":"Current Neurovascular Research"},{"key":"8030_CR22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1083\/jcb.200407021","volume":"168","author":"G. Dobrowolny","year":"2005","unstructured":"Dobrowolny, G., Giacinti, C., Pelosi, L., et\u00a0al. (2005). Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model. The Journal of Cell Biology, 168, 193\u2013199.","journal-title":"The Journal of Cell Biology"},{"key":"8030_CR23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0022-510X(01)00610-4","volume":"191","author":"V. E. Drory","year":"2001","unstructured":"Drory, V. E., Goltsman, E., Reznik, J. G., Mosek, A., & Korczyn, A. D. (2001). The value of muscle exercise in patients with amyotrophic lateral sclerosis. Journal of the Neurological Sciences, 191, 133\u2013137.","journal-title":"Journal of the Neurological Sciences"},{"key":"8030_CR24","doi-asserted-by":"crossref","first-page":"11159","DOI":"10.1073\/pnas.0402026101","volume":"101","author":"L. Dupuis","year":"2004","unstructured":"Dupuis, L., Oudart, H., Rene, F., Gonzalez de Aguilar, J. L., & Loeffler, J. P. (2004). Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: benefit of a high-energy diet in a transgenic mouse model. Proceedings of the National Academy of Sciences of the United States of America, 101, 11159\u201311164.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"8030_CR25","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00005072-199705000-00008","volume":"56","author":"H. D. Durham","year":"1997","unstructured":"Durham, H. D., Roy, J., Dong, L., & Figlewicz, D. A. (1997). Aggregation of mutant Cu\/Zn superoxide dismutase proteins in a culture model of ALS. Journal of Neuropathology and Experimental Neurology, 56, 523\u2013530.","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"key":"8030_CR26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/mus.880160107","volume":"16","author":"A. Eisen","year":"1993","unstructured":"Eisen, A., Schulzer, M., MacNeil, M., Pant, B., & Mak, E. (1993). Duration of amyotrophic lateral sclerosis is age dependent. Muscle Nerve, 16, 27\u201332.","journal-title":"Muscle Nerve"},{"key":"8030_CR27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1089\/neu.2005.22.157","volume":"22","author":"C. Engesser-Cesar","year":"2005","unstructured":"Engesser-Cesar, C., Anderson, A. J., Basso, D. M., Edgerton, V. R., & Cotman, C. W. (2005). Voluntary wheel running improves recovery from a moderate spinal cord injury. Journal of Neurotrauma, 22, 157\u2013171.","journal-title":"Journal of Neurotrauma"},{"key":"8030_CR28","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1111\/j.1460-9568.2007.05469.x","volume":"25","author":"C. Engesser-Cesar","year":"2007","unstructured":"Engesser-Cesar, C., Ichiyama, R. M., Nefas, A. L., et\u00a0al. (2007). Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth. European Journal of Neuroscience, 25, 1931\u20131939.","journal-title":"European Journal of Neuroscience"},{"key":"8030_CR29","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.brainres.2007.04.044","volume":"1157","author":"S. Garbuzova-Davis","year":"2007","unstructured":"Garbuzova-Davis, S., Haller, E., Saporta, S., Kolomey, I., Nicosia, S. V., & Sanberg, P. R. (2007). Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS. Brain Research, 1157, 126\u2013137.","journal-title":"Brain Research"},{"key":"8030_CR30","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1152\/japplphysiol.00482.2006","volume":"101","author":"P. Gardiner","year":"2006","unstructured":"Gardiner, P., Dai, Y., & Heckman, C. J. (2006). Effects of exercise training on alpha-motoneurons. Journal of Applied Physiology, 101, 1228\u20131236.","journal-title":"Journal of Applied Physiology"},{"key":"8030_CR31","doi-asserted-by":"crossref","first-page":"7615","DOI":"10.1523\/JNEUROSCI.1245-05.2005","volume":"25","author":"C. Grondard","year":"2005","unstructured":"Grondard, C., Biondi, O., Armand, A. S., et\u00a0al. (2005). Regular exercise prolongs survival in a type 2 spinal muscular atrophy model mouse. Journal of Neuroscience, 25, 7615\u20137622.","journal-title":"Journal of Neuroscience"},{"key":"8030_CR32","doi-asserted-by":"crossref","first-page":"12524","DOI":"10.1073\/pnas.0705044104","volume":"104","author":"A. Gruzman","year":"2007","unstructured":"Gruzman, A., Wood, W. L., Alpert, E., et\u00a0al. (2007). Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences of the United States of America, 104, 12524\u201312529.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"8030_CR33","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/BF00313868","volume":"232","author":"S. S. Gubbay","year":"1985","unstructured":"Gubbay, S. S., Kahana, E., Zilber, N., Cooper, G., Pintov, S., & Leibowitz, Y. (1985). Amyotrophic lateral sclerosis. A study of its presentation and prognosis. Journal of Neurology, 232, 295\u2013300.","journal-title":"Journal of Neurology"},{"key":"8030_CR34","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.8209258","volume":"264","author":"M. E. Gurney","year":"1994","unstructured":"Gurney, M. E., Pu, H., Chiu, A. Y., et\u00a0al. (1994). Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science, 264, 1772\u20131775.","journal-title":"Science"},{"key":"8030_CR35","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/mus.20255","volume":"31","author":"M. J. Hamadeh","year":"2005","unstructured":"Hamadeh, M. J., Rodriguez, M. C., Kaczor, J. J., & Tarnopolsky, M. A. (2005). Caloric restriction transiently improves motor performance but hastens clinical onset of disease in the Cu\/Zn-superoxide dismutase mutant G93A mouse. Muscle Nerve, 31, 214\u2013220.","journal-title":"Muscle Nerve"},{"key":"8030_CR36","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1212\/WNL.26.5.460","volume":"26","author":"W. A. Horton","year":"1976","unstructured":"Horton, W. A., Eldridge, R., & Brody, J. A. (1976). Familial motor neuron disease. Evidence for at least three different types. Neurology, 26, 460\u2013465.","journal-title":"Neurology"},{"key":"8030_CR37","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1093\/brain\/awh160","volume":"127","author":"K. J. Hutchinson","year":"2004","unstructured":"Hutchinson, K. J., Gomez-Pinilla, F., Crowe, M. J., Ying, Z., & Basso, D. M. (2004). Three exercise paradigms differentially improve sensory recovery after spinal cord contusion in rats. Brain, 127, 1403\u20131414.","journal-title":"Brain"},{"key":"8030_CR38","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0003-9861(92)90431-U","volume":"298","author":"H. Ischiropoulos","year":"1992","unstructured":"Ischiropoulos, H., Zhu, L., Chen, J., et\u00a0al. (1992). Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Archives of Biochemistry and Biophysics, 298, 431\u2013437.","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"8030_CR39","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/mus.880121008","volume":"12","author":"C. K. Jablecki","year":"1989","unstructured":"Jablecki, C. K., Berry, C., & Leach, J. (1989). Survival prediction in amyotrophic lateral sclerosis. Muscle Nerve, 12, 833\u2013841.","journal-title":"Muscle Nerve"},{"key":"8030_CR40","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0304-3940(87)90625-2","volume":"78","author":"B. J. Jasmin","year":"1987","unstructured":"Jasmin, B. J., Lavoie, P. A., & Gardiner, P. F. (1987). Fast axonal transport of acetylcholinesterase in rat sciatic motoneurons is enhanced following prolonged daily running, but not following swimming. Neuroscience Letters, 78, 156\u2013160.","journal-title":"Neuroscience Letters"},{"key":"8030_CR41","doi-asserted-by":"crossref","first-page":"C731","DOI":"10.1152\/ajpcell.1988.255.6.C731","volume":"255","author":"B. J. Jasmin","year":"1988","unstructured":"Jasmin, B. J., Lavoie, P. A., & Gardiner, P. F. (1988). Fast axonal transport of labeled proteins in motoneurons of exercise-trained rats. American Journal of Physiology, 255, C731\u2013736.","journal-title":"American Journal of Physiology"},{"key":"8030_CR42","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/sj.embor.7400826","volume":"7","author":"N. Jokic","year":"2006","unstructured":"Jokic, N., Gonzalez de Aguilar, J. L., Dimou, L., et\u00a0al. (2006). The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model. EMBO Reports, 7, 1162\u20131167.","journal-title":"EMBO Reports"},{"key":"8030_CR43","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nn0507-535","volume":"10","author":"J. P. Julien","year":"2007","unstructured":"Julien, J. P. (2007). ALS: astrocytes move in as deadly neighbors. Nature of Neuroscience, 10, 535\u2013537.","journal-title":"Nature of Neuroscience"},{"key":"8030_CR44","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/ana.20451","volume":"57","author":"B. K. Kaspar","year":"2005","unstructured":"Kaspar, B. K., Frost, L. M., Christian, L., Umapathi, P., & Gage, F. H. (2005). Synergy of insulin-like growth factor-1 and exercise in amyotrophic lateral sclerosis. Annals of Neurology, 57, 649\u2013655.","journal-title":"Annals of Neurology"},{"key":"8030_CR45","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1126\/science.1086137","volume":"301","author":"B. K. Kaspar","year":"2003","unstructured":"Kaspar, B. K., Llado, J., Sherkat, N., Rothstein, J. D., & Gage, F. H. (2003). Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science, 301, 839\u2013842.","journal-title":"Science"},{"key":"8030_CR46","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/jnr.20562","volume":"81","author":"S. U. Kim","year":"2005","unstructured":"Kim, S. U., & de Vellis, J. (2005). Microglia in health and disease. Journal of Neuroscience Research, 81, 302\u2013313.","journal-title":"Journal of Neuroscience Research"},{"key":"8030_CR47","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1002\/ana.10597","volume":"53","author":"I. G. Kirkinezos","year":"2003","unstructured":"Kirkinezos, I. G., Hernandez, D., Bradley, W. G., & Moraes, C. T. (2003). Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis. Annals of Neurology, 53, 804\u2013807.","journal-title":"Annals of Neurology"},{"key":"8030_CR48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(02)02239-4","volume":"934","author":"J. A. Kleim","year":"2002","unstructured":"Kleim, J. A., Cooper, N. R., & VandenBerg, P. M. (2002). Exercise induces angiogenesis but does not alter movement representations within rat motor cortex. Brain Research, 934, 1\u20136.","journal-title":"Brain Research"},{"key":"8030_CR49","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1023\/A:1026025408742","volume":"28","author":"J. A. Kleim","year":"2003","unstructured":"Kleim, J. A., Jones, T. A., & Schallert, T. (2003). Motor enrichment and the induction of plasticity before or after brain injury. Neurochemical Research, 28, 1757\u20131769.","journal-title":"Neurochemical Research"},{"key":"8030_CR50","first-page":"245","volume":"56","author":"J. F. Kurtzke","year":"1991","unstructured":"Kurtzke, J. F. (1991). Risk factors in amyotrophic lateral sclerosis. Advanced Neurology, 56, 245\u2013270.","journal-title":"Advanced Neurology"},{"key":"8030_CR51","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.bbadis.2006.04.005","volume":"1762","author":"D. Lambrechts","year":"2006","unstructured":"Lambrechts, D., & Carmeliet, P. (2006). VEGF at the neurovascular interface: therapeutic implications for motor neuron disease. Biochimica et Biophysica Acta, 1762, 1109\u20131121.","journal-title":"Biochimica et Biophysica Acta"},{"key":"8030_CR52","doi-asserted-by":"crossref","unstructured":"Lepore, A. C., Haenggeli, C., Gasmi, M., et\u00a0al. (2007). Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1(G93A) model of ALS. Brain Research [epub].","DOI":"10.1016\/j.brainres.2007.09.034"},{"key":"8030_CR53","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.neulet.2005.06.009","volume":"386","author":"J. Li","year":"2005","unstructured":"Li, J., Ding, Y. H., Rafols, J. A., Lai, Q., McAllister, J. P., 2nd, & Ding, Y. (2005). Increased astrocyte proliferation in rats after running exercise. Neuroscience Letters, 386, 160\u2013164.","journal-title":"Neuroscience Letters"},{"key":"8030_CR54","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1111\/j.1460-9568.2004.03769.x","volume":"20","author":"D. Liebetanz","year":"2004","unstructured":"Liebetanz, D., Hagemann, K., von Lewinski, F., Kahler, E., & Paulus, W. (2004). Extensive exercise is not harmful in amyotrophic lateral sclerosis. European Journal of Neuroscience, 20, 3115\u20133120.","journal-title":"European Journal of Neuroscience"},{"key":"8030_CR55","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1001\/archneur.55.2.201","volume":"55","author":"W. T. Longstreth","year":"1998","unstructured":"Longstreth, W. T., McGuire, V., Koepsell, T. D., Wang, Y., & van Belle, G. (1998). Risk of amyotrophic lateral sclerosis and history of physical activity: a population-based case-control study. Archives of Neurology, 55, 201\u2013206.","journal-title":"Archives of Neurology"},{"key":"8030_CR56","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/mus.20004","volume":"29","author":"D. J. Mahoney","year":"2004","unstructured":"Mahoney, D. J., Rodriguez, C., Devries, M., Yasuda, N., & Tarnopolsky, M. A. (2004). Effects of high-intensity endurance exercise training in the G93A mouse model of amyotrophic lateral sclerosis. Muscle Nerve, 29, 656\u2013662.","journal-title":"Muscle Nerve"},{"key":"8030_CR57","doi-asserted-by":"crossref","first-page":"29626","DOI":"10.1074\/jbc.M203065200","volume":"277","author":"M. Mattiazzi","year":"2002","unstructured":"Mattiazzi, M., D\u2019Aurelio, M., Gajewski, C. D., et\u00a0al. (2002). Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice. Journal of Biological Chemistry, 277, 29626\u201329633.","journal-title":"Journal of Biological Chemistry"},{"key":"8030_CR58","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1385\/NMM:9:1:17","volume":"9","author":"M. P. Mattson","year":"2007","unstructured":"Mattson, M. P., Cutler, R. G., & Camandola, S. (2007). Energy intake and amyotrophic lateral sclerosis. NeuroMolecular Medicine, 9, 17\u201320.","journal-title":"NeuroMolecular Medicine"},{"key":"8030_CR59","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/ana.410390215","volume":"39","author":"R. G. Miller","year":"1996","unstructured":"Miller, R. G., Petajan, J. H., Bryan, W. W., et\u00a0al. (1996). A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. rhCNTF ALS Study Group. Annals of Neurology, 39, 256\u2013260.","journal-title":"Annals of Neurology"},{"key":"8030_CR60","doi-asserted-by":"crossref","unstructured":"Mitchell, J., Wokke, J., & Borasio, G. (2007). Recombinant human insulin-like growth factor I (rhIGF-I) for amyotrophic lateral sclerosis\/motor neuron disease. Cochrane Database of Systematic Reviews, CD002064.","DOI":"10.1002\/14651858.CD002064.pub2"},{"key":"8030_CR61","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1212\/WNL.36.4.511","volume":"36","author":"D. W. Mulder","year":"1986","unstructured":"Mulder, D. W., Kurland, L. T., Offord, K. P., & Beard, C. M. (1986). Familial adult motor neuron disease: amyotrophic lateral sclerosis. Neurology, 36, 511\u2013517.","journal-title":"Neurology"},{"key":"8030_CR62","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1212\/WNL.38.3.409","volume":"38","author":"T. L. Munsat","year":"1988","unstructured":"Munsat, T. L., Andres, P. L., Finison, L., Conlon, T., & Thibodeau, L. (1988). The natural history of motoneuron loss in amyotrophic lateral sclerosis. Neurology, 38, 409\u2013413.","journal-title":"Neurology"},{"key":"8030_CR63","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jns.2005.04.011","volume":"235","author":"I. Nagano","year":"2005","unstructured":"Nagano, I., Ilieva, H., Shiote, M., et\u00a0al. (2005). Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of Amyotrophic Lateral Sclerosis. Journal of the Neurological Sciences, 235, 61\u201368.","journal-title":"Journal of the Neurological Sciences"},{"key":"8030_CR64","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/jnr.20668","volume":"82","author":"H. Narai","year":"2005","unstructured":"Narai, H., Nagano, I., Ilieva, H., et\u00a0al. (2005). Prevention of spinal motor neuron death by insulin-like growth factor-1 associating with the signal transduction systems in SODG93A transgenic mice. Journal of Neuroscience Research, 82, 452\u2013457.","journal-title":"Journal of Neuroscience Research"},{"key":"8030_CR65","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/oxfordjournals.aje.a112848","volume":"110","author":"N. Nathanson","year":"1979","unstructured":"Nathanson, N., & Martin, J. R. (1979). The epidemiology of poliomyelitis: enigmas surrounding its appearance, epidemicity, and disappearance. American Journal of Epidemiology, 110, 672\u2013692.","journal-title":"American Journal of Epidemiology"},{"key":"8030_CR66","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0022-510X(99)00218-X","volume":"169","author":"A. C. Pinto","year":"1999","unstructured":"Pinto, A. C., Alves, M., Nogueira, A., et\u00a0al. (1999). Can amyotrophic lateral sclerosis patients with respiratory insufficiency exercise? J. Neurological Sciences, 169, 69\u201375.","journal-title":"Neurological Sciences"},{"key":"8030_CR67","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/14660820600640596","volume":"7","author":"M. M. Qureshi","year":"2006","unstructured":"Qureshi, M. M., Hayden, D., Urbinelli, L., et\u00a0al. (2006). Analysis of factors that modify susceptibility and rate of progression in amyotrophic lateral sclerosis (ALS). Amyotrophic Lateral Sclerosis, 7, 173\u2013182.","journal-title":"Amyotrophic Lateral Sclerosis"},{"key":"8030_CR68","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1073\/pnas.92.3.689","volume":"92","author":"M. E. Ripps","year":"1995","unstructured":"Ripps, M. E., Huntley, G. W., Hof, P. R., Morrison, J. H., & Gordon, J. W. (1995). Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences of the United States of America, 92, 689\u2013693.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"8030_CR69","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","volume":"362","author":"D. R. Rosen","year":"1993","unstructured":"Rosen, D. R., Siddique, T., Patterson, D., et\u00a0al. (1993). Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature, 362, 59\u201362.","journal-title":"Nature"},{"key":"8030_CR70","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1212\/WNL.59.5.773","volume":"59","author":"N. Scarmeas","year":"2002","unstructured":"Scarmeas, N., Shih, T., Stern, Y., Ottman, R., & Rowland, L. P. (2002). Premorbid weight, body mass, and varsity athletics in ALS. Neurology, 59, 773\u2013775.","journal-title":"Neurology"},{"key":"8030_CR71","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nn1360","volume":"8","author":"E. Storkebaum","year":"2005","unstructured":"Storkebaum, E., Lambrechts, D., Dewerchin, M., et\u00a0al. (2005). Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nature of Neuroscience, 8, 85\u201392.","journal-title":"Nature of Neuroscience"},{"key":"8030_CR72","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1600-0404.1996.tb00038.x","volume":"94","author":"D. Strickland","year":"1996","unstructured":"Strickland, D., Smith, S. A., Dolliff, G., Goldman, L., & Roelofs, R. I. (1996). Physical activity, trauma, and ALS: a case-control study. Acta Neurologica Scandinavica, 94, 45\u201350.","journal-title":"Acta Neurologica Scandinavica"},{"key":"8030_CR73","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0306-4522(02)00664-4","volume":"117","author":"R. A. Swain","year":"2003","unstructured":"Swain, R. A., Harris, A. B., Wiener, E. C., et\u00a0al. (2003). Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat. Neuroscience, 117, 1037\u20131046.","journal-title":"Neuroscience"},{"key":"8030_CR74","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nn1603","volume":"9","author":"M. Urushitani","year":"2006","unstructured":"Urushitani, M., Sik, A., Sakurai, T., Nukina, N., Takahashi, R., & Julien, J. P. (2006). Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Nature of Neuroscience, 9, 108\u2013118.","journal-title":"Nature of Neuroscience"},{"key":"8030_CR75","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/35008142","volume":"404","author":"A. Dellen van","year":"2000","unstructured":"van Dellen, A., Blakemore, C., Deacon, R., York, D., & Hannan, A. J. (2000). Delaying the onset of Huntington\u2019s in mice. Nature, 404, 721\u2013722.","journal-title":"Nature"},{"key":"8030_CR76","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0960-8966(03)00104-4","volume":"13","author":"J. H. Veldink","year":"2003","unstructured":"Veldink, J. H., Bar, P. R., Joosten, E. A., Otten, M., Wokke, J. H., & van den Berg, L. H. (2003). Sexual differences in onset of disease and response to exercise in a transgenic model of ALS. Neuromuscular Disorders, 13, 737\u2013743.","journal-title":"Neuromuscular Disorders"},{"key":"8030_CR77","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1212\/01.WNL.0000149513.82332.5C","volume":"64","author":"J. H. Veldink","year":"2005","unstructured":"Veldink, J. H., Kalmijn, S., Groeneveld, G. J., Titulaer, M. J., Wokke, J. H., & van den Berg, L. H. (2005). Physical activity and the association with sporadic ALS. Neurology, 64, 241\u2013245.","journal-title":"Neurology"},{"key":"8030_CR78","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1126\/science.271.5248.515","volume":"271","author":"M. Wiedau-Pazos","year":"1996","unstructured":"Wiedau-Pazos, M., Goto, J. J., Rabizadeh, S., et\u00a0al. (1996). Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis. Science, 271, 515\u2013518.","journal-title":"Science"},{"key":"8030_CR79","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1046\/j.0305-1846.2003.00518.x","volume":"29","author":"J. D. Wood","year":"2003","unstructured":"Wood, J. D., Beaujeux, T. P., & Shaw, P. J. (2003). Protein aggregation in motor neurone disorders. Neuropathology and Applied Neurobiology, 29, 529\u2013545.","journal-title":"Neuropathology and Applied Neurobiology"},{"key":"8030_CR80","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/ana.21221","volume":"62","author":"D. Wu","year":"2007","unstructured":"Wu, D., Yu, W., Kishikawa, H., et\u00a0al. (2007). Angiogenin loss-of-function mutations in amyotrophic lateral sclerosis. Annals of Neurology, 62, 609\u2013617.","journal-title":"Annals of Neurology"},{"key":"8030_CR81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nn2047","volume":"11","author":"K. Yamanaka","year":"2008","unstructured":"Yamanaka, K., Chun, S. J., Boillee, S., et al. (2008). Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nature Neuroscience, 11, 1\u20133.","journal-title":"Nature Neuroscience"}],"container-title":["NeuroMolecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-008-8030-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12017-008-8030-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-008-8030-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T12:35:02Z","timestamp":1708605302000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12017-008-8030-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,20]]},"references-count":81,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["8030"],"URL":"https:\/\/doi.org\/10.1007\/s12017-008-8030-5","relation":{},"ISSN":["1535-1084","1559-1174"],"issn-type":[{"value":"1535-1084","type":"print"},{"value":"1559-1174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,20]]}}}