{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:49:44Z","timestamp":1791078584031,"version":"4.1.0"},"reference-count":138,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T00:00:00Z","timestamp":1242864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuromol Med"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1007\/s12017-009-8063-4","type":"journal-article","created":{"date-parts":[[2009,5,20]],"date-time":"2009-05-20T07:20:03Z","timestamp":1242804003000},"page":"183-199","source":"Crossref","is-referenced-by-count":108,"title":["Gene Dysregulation in Huntington\u2019s Disease: REST, MicroRNAs and Beyond"],"prefix":"10.1007","volume":"11","author":[{"given":"Rory","family":"Johnson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel J.","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,5,21]]},"reference":[{"key":"8063_CR2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1126\/science.1116502","volume":"310","author":"JF Abelson","year":"2005","unstructured":"Abelson, J. F., Kwan, K. Y., O\u2019Roak, B. J., Baek, D. Y., Stillman, A. A., et al. (2005). Sequence variants in SLITRK1 are associated with Tourette\u2019s syndrome. Science, 310, 317\u2013320. doi: 10.1126\/science.1116502 .","journal-title":"Science"},{"key":"8063_CR3","doi-asserted-by":"crossref","first-page":"18017","DOI":"10.1073\/pnas.0508823102","volume":"102","author":"AA Aboobaker","year":"2005","unstructured":"Aboobaker, A. A., Tomancak, P., Patel, N., Rubin, G. M., & Lai, E. C. (2005). Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development. Proceedings of the National Academy of Sciences of the United States of America, 102, 18017\u201318022. doi: 10.1073\/pnas.0508823102 .","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"8063_CR4","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/39885","volume":"389","author":"CA Altar","year":"1997","unstructured":"Altar, C. A., Cai, N., Bliven, T., Juhasz, M., Conner, J. M., et al. (1997). Anterograde transport of brain-derived neurotrophic factor and its role in the brain. Nature, 389, 856\u2013860. doi: 10.1038\/39885 .","journal-title":"Nature"},{"key":"8063_CR5","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/00005072-199704000-00013","volume":"56","author":"T Arzberger","year":"1997","unstructured":"Arzberger, T., Krampfl, K., Leimgruber, S., & Weindl, A. (1997). Changes of NMDA receptor subunit (NR1, NR2B) and glutamate transporter (GLT1) mRNA expression in Huntington\u2019s disease\u2014an in situ hybridization study. Journal of Neuropathology and Experimental Neurology, 56, 440\u2013454. doi: 10.1097\/00005072-199704000-00013 .","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"key":"8063_CR6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/ana.410420213","volume":"42","author":"SJ Augood","year":"1997","unstructured":"Augood, S. J., Faull, R. L., & Emson, P. C. (1997). Dopamine D1 and D2 receptor gene expression in the striatum in Huntington\u2019s disease. Annals of Neurology, 42, 215\u2013221. doi: 10.1002\/ana.410420213 .","journal-title":"Annals of Neurology"},{"key":"8063_CR7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuron.2005.06.005","volume":"47","author":"B-I Bae","year":"2005","unstructured":"Bae, B.-I., Xu, H., Igarashi, S., Fujimuro, M., Agrawal, N., et al. (2005). p53 mediates cellular dysfunction and behavioral abnormalities in huntington\u2019s disease. Neuron, 47, 29\u201341. doi: 10.1016\/j.neuron.2005.06.005 .","journal-title":"Neuron"},{"key":"8063_CR8","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1261\/rna.783108","volume":"14","author":"M Bak","year":"2008","unstructured":"Bak, M., Silahtaroglu, A., Moller, M., Christensen, M., Rath, M. F., et al. (2008). MicroRNA expression in the adult mouse central nervous system. RNA, 14, 432\u2013444. doi: 10.1261\/rna.783108 .","journal-title":"RNA"},{"key":"8063_CR9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0896-6273(01)00371-3","volume":"31","author":"N Ballas","year":"2001","unstructured":"Ballas, N., Battaglioli, E., Atouf, F., Andres, M. E., Chenoweth, J., et al. (2001). Regulation of neuronal traits by a novel transcriptional complex. Neuron, 31, 353\u2013365. doi: 10.1016\/S0896-6273(01)00371-3 .","journal-title":"Neuron"},{"key":"8063_CR10","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2003","unstructured":"Bartel, D. P. (2003). MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell, 116, 281\u2013297. doi: 10.1016\/S0092-8674(04)00045-5 .","journal-title":"Cell"},{"key":"8063_CR11","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","volume":"136","author":"DP Bartel","year":"2009","unstructured":"Bartel, D. P. (2009). MicroRNAs: Target recognition and regulatory functions. Cell, 136, 215\u2013233. doi: 10.1016\/j.cell.2009.01.002 .","journal-title":"Cell"},{"key":"8063_CR12","doi-asserted-by":"crossref","first-page":"10720","DOI":"10.1523\/JNEUROSCI.2126-08.2008","volume":"28","author":"CL Benn","year":"2008","unstructured":"Benn, C. L., Sun, T., Sadri-Vakili, G., McFarland, K. N., DiRocco, D. P., et al. (2008). Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner. Journal of Neuroscience, 28, 10720\u201310733. doi: 10.1523\/JNEUROSCI.2126-08.2008 .","journal-title":"Journal of Neuroscience"},{"key":"8063_CR13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.molcel.2006.07.030","volume":"24","author":"J Bilen","year":"2006","unstructured":"Bilen, J., Liu, N., Burnett, B., Pittman, R., & Bonini, N. (2006). MicroRNA pathways modulate polyglutamine-induced neurodegeneration. Molecular Cell, 24, 157\u2013163. doi: 10.1016\/j.molcel.2006.07.030 .","journal-title":"Molecular Cell"},{"key":"8063_CR14","doi-asserted-by":"crossref","first-page":"11023","DOI":"10.1073\/pnas.0504921102","volume":"102","author":"F Borovecki","year":"2005","unstructured":"Borovecki, F., Lovrecic, L., Zhou, J., Jeong, H., Then, F., et al. (2005). Genome-wide expression profiling of human blood reveals biomarkers for Huntington\u2019s disease. PNAS, 102, 11023\u201311028. doi: 10.1073\/pnas.0504921102 .","journal-title":"PNAS"},{"key":"8063_CR15","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/hmg\/8.9.1647","volume":"8","author":"JM Boutell","year":"1999","unstructured":"Boutell, J. M., Thomas, P., Neal, J. W., Weston, V. J., Duce, J., et al. (1999). Aberrant interactions of transcriptional repressor proteins with the Huntington\u2019s disease gene product, huntingtin. Human Molecular Genetics, 8, 1647\u20131655. doi: 10.1093\/hmg\/8.9.1647 .","journal-title":"Human Molecular Genetics"},{"key":"8063_CR16","doi-asserted-by":"crossref","first-page":"10458","DOI":"10.1073\/pnas.0401827101","volume":"101","author":"AW Bruce","year":"2004","unstructured":"Bruce, A. W., Donaldson, I. J., Wood, I. C., Yerbury, S. A., Sadowski, M. I., et al. (2004). Genome-wide analysis of repressor element 1 silencing transcription factor\/neuron-restrictive silencing factor (REST\/NRSF) target genes. PNAS, 101, 10458\u201310463. doi: 10.1073\/pnas.0401827101 .","journal-title":"PNAS"},{"key":"8063_CR17","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1523\/JNEUROSCI.23-06-02112.2003","volume":"23","author":"A Calderone","year":"2003","unstructured":"Calderone, A., Jover, T., Noh, K.-M., Tanaka, H., Yokota, H., et al. (2003). Ischemic insults derepress the gene silencer REST in neurons destined to die. Journal of Neuroscience, 23, 2112\u20132121.","journal-title":"Journal of Neuroscience"},{"key":"8063_CR18","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nm1582","volume":"13","author":"A Care","year":"2007","unstructured":"Care, A., Catalucci, D., Felicetti, F., Bonci, D., Addario, A., et al. (2007). MicroRNA-133 controls cardiac hypertrophy. Nature Medicine, 13, 613\u2013618. doi: 10.1038\/nm1582 .","journal-title":"Nature Medicine"},{"key":"8063_CR19","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1126\/science.1112014","volume":"309","author":"P Carninci","year":"2005","unstructured":"Carninci, P., Kasukawa, T., Katayama, S., Gough, J., Frith, M. C., et al. (2005). The transcriptional landscape of the mammalian genome. Science, 309, 1559\u20131563. doi: 10.1126\/science.1112014 .","journal-title":"Science"},{"key":"8063_CR20","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nrn1806","volume":"6","author":"E Cattaneo","year":"2005","unstructured":"Cattaneo, E., Zuccato, C., & Tartari, M. (2005). Normal huntingtin function: an alternative approach to Huntington\u2019s disease. Nature Reviews Neuroscience, 6, 919\u2013930. doi: 10.1038\/nrn1806 .","journal-title":"Nature Reviews Neuroscience"},{"key":"8063_CR21","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.pneurobio.2007.03.004","volume":"83","author":"JH Cha","year":"2007","unstructured":"Cha, J. H. (2007). Transcriptional signatures in Huntington\u2019s disease. Progress in Neurobiology, 83, 228\u2013248. doi: 10.1016\/j.pneurobio.2007.03.004 .","journal-title":"Progress in Neurobiology"},{"key":"8063_CR22","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ng1725","volume":"38","author":"J-F Chen","year":"2006","unstructured":"Chen, J.-F., Mandel, E. M., Thomson, J. M., Wu, Q., Callis, T. E., et al. (2006). The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nature Genetics, 38, 228\u2013233. doi: 10.1038\/ng1725 .","journal-title":"Nature Genetics"},{"key":"8063_CR23","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/2431","volume":"20","author":"Z-F Chen","year":"1998","unstructured":"Chen, Z.-F., Paquette, A. J., & Anderson, D. J. (1998). NRSF\/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis. Nature Genetics, 20, 136\u2013142. doi: 10.1038\/2431 .","journal-title":"Nature Genetics"},{"key":"8063_CR24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.nbd.2005.11.001","volume":"22","author":"AS Chen-Plotkin","year":"2006","unstructured":"Chen-Plotkin, A. S., Sadri-Vakili, G., Yohrling, G. J., Braveman, M. W., Benn, C. L., et al. (2006). Decreased association of the transcription factor Sp1 with genes downregulated in Huntington\u2019s disease. Neurobiology of Disease, 22, 233\u2013241. doi: 10.1016\/j.nbd.2005.11.001 .","journal-title":"Neurobiology of Disease"},{"key":"8063_CR25","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/0092-8674(95)90298-8","volume":"80","author":"J Chong","year":"1995","unstructured":"Chong, J., Tapia-Ramirez, J., Kim, S., Toledo-Aral, J., Zheng, Y., et al. (1995). REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell, 80, 949\u2013957. doi: 10.1016\/0092-8674(95)90298-8 .","journal-title":"Cell"},{"issue":"6","key":"8063_CR26","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.molcel.2009.01.026","volume":"33","author":"CM Clemson","year":"2009","unstructured":"Clemson, C. M., Hutchinson, J. N., Sara, S. A., Ensminger, A. W., Fox, A. H., et al. (2009). An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles. Molecular Cell, 33(6), 717\u2013726.","journal-title":"Molecular Cell"},{"key":"8063_CR27","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1073\/pnas.0511041103","volume":"103","author":"C Conaco","year":"2006","unstructured":"Conaco, C., Otto, S., Han, J.-J., & Mandel, G. (2006). Reciprocal actions of REST and a microRNA promote neuronal identity. PNAS, 103, 2422\u20132427. doi: 10.1073\/pnas.0511041103 .","journal-title":"PNAS"},{"key":"8063_CR28","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1101\/gr.078378.108","volume":"18","author":"ME Dinger","year":"2008","unstructured":"Dinger, M. E., Amaral, P. P., Mercer, T. R., Pang, K. C., Bruce, S. J., et al. (2008). Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. Genome Research, 18, 1433\u20131445. doi: 10.1101\/gr.078378.108 .","journal-title":"Genome Research"},{"key":"8063_CR29","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1126\/science.1072613","volume":"296","author":"AW Dunah","year":"2002","unstructured":"Dunah, A. W., Jeong, H., Griffin, A., Kim, Y. M., Standaert, D. G., et al. (2002). Sp1 and TAFII130 transcriptional activity disrupted in early Huntington\u2019s disease. Science, 296, 2238\u20132243. doi: 10.1126\/science.1072613 .","journal-title":"Science"},{"key":"8063_CR30","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.mehy.2007.02.046","volume":"69","author":"BR Eskenazi","year":"2007","unstructured":"Eskenazi, B. R., Wilson-Rich, N. S., & Starks, P. T. (2007). A Darwinian approach to Huntington\u2019s disease: Subtle health benefits of a neurological disorder. Medical Hypotheses, 69, 1183\u20131189. doi: 10.1016\/j.mehy.2007.02.046 .","journal-title":"Medical Hypotheses"},{"key":"8063_CR31","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nm1784","volume":"14","author":"MA Faghihi","year":"2008","unstructured":"Faghihi, M. A., Modarresi, F., Khalil, A. M., Wood, D. E., Sahagan, B. G., et al. (2008). Expression of a noncoding RNA is elevated in Alzheimer\u2019s disease and drives rapid feed-forward regulation of beta-secretase. Nature Medicine, 14, 723\u2013730. doi: 10.1038\/nm1784 .","journal-title":"Nature Medicine"},{"key":"8063_CR32","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1126\/science.1121158","volume":"310","author":"KK Farh","year":"2005","unstructured":"Farh, K. K., Grimson, A., Jan, C., Lewis, B. P., Johnston, W. K., et al. (2005). The widespread impact of mammalian microRNAs on mRNA repression and evolution. Science, 310, 1817\u20131821. doi: 10.1126\/science.1121158 .","journal-title":"Science"},{"key":"8063_CR33","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1101\/gad.1416106","volume":"20","author":"J Feng","year":"2006","unstructured":"Feng, J., Bi, C., Clark, B. S., Mady, R., Shah, P., et al. (2006). The Evf-2 noncoding RNA is transcribed from the Dlx-5\/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator. Genes and Development, 20, 1470\u20131484. doi: 10.1101\/gad.1416106 .","journal-title":"Genes and Development"},{"key":"8063_CR34","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1126\/science.2931802","volume":"230","author":"RJ Ferrante","year":"1985","unstructured":"Ferrante, R. J., Kowall, N. W., Beal, M. F., Richardson, E. P., Jr., Bird, E. D., et al. (1985). Selective sparing of a class of striatal neurons in Huntington\u2019s disease. Science, 230, 561\u2013563. doi: 10.1126\/science.2931802 .","journal-title":"Science"},{"key":"8063_CR35","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nrg2290","volume":"9","author":"W Filipowicz","year":"2008","unstructured":"Filipowicz, W., Bhattacharyya, S. N., & Sonenberg, N. (2008). Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight? Nature Reviews. Genetics, 9, 102\u2013114. doi: 10.1038\/nrg2290 .","journal-title":"Nature Reviews. Genetics"},{"key":"8063_CR36","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nbt1394","volume":"26","author":"MR Friedlander","year":"2008","unstructured":"Friedlander, M. R., Chen, W., Adamidi, C., Maaskola, J., Einspanier, R., et al. (2008). Discovering microRNAs from deep sequencing data using miRDeep. Nature Biotechnology, 26, 407\u2013415. doi: 10.1038\/nbt1394 .","journal-title":"Nature Biotechnology"},{"key":"8063_CR37","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nrm2621","volume":"10","author":"VK Gangaraju","year":"2009","unstructured":"Gangaraju, V. K., & Lin, H. (2009). MicroRNAs: Key regulators of stem cells. Nature Reviews. Molecular Cell Biology, 10, 116\u2013125. doi: 10.1038\/nrm2621 .","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"8063_CR38","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1126\/science.1109020","volume":"308","author":"AJ Giraldez","year":"2005","unstructured":"Giraldez, A. J., Cinalli, R. M., Glasner, M. E., Enright, A. J., Thomson, J. M., et al. (2005). MicroRNAs regulate brain morphogenesis in zebrafish. Science, 308, 833\u2013838. doi: 10.1126\/science.1109020 .","journal-title":"Science"},{"key":"8063_CR39","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1634\/stemcells.2006-0207","volume":"25","author":"DJ Greenway","year":"2007","unstructured":"Greenway, D. J., Street, M., Jeffries, A., & Buckley, N. J. (2007). RE1 silencing transcription factor maintains a repressive chromatin environment in embryonic hippocampal neural stem cells. Stem Cells, 25, 354\u2013363. doi: 10.1634\/stemcells.2006-0207 .","journal-title":"Stem Cells"},{"key":"8063_CR40","doi-asserted-by":"crossref","first-page":"D109","DOI":"10.1093\/nar\/gkh023","volume":"32","author":"S Griffiths-Jones","year":"2004","unstructured":"Griffiths-Jones, S. (2004). The microRNA registry. Nucleic Acids Research, 32, D109\u2013D111. doi: 10.1093\/nar\/gkh023 .","journal-title":"Nucleic Acids Research"},{"key":"8063_CR41","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/nature05939","volume":"447","author":"L He","year":"2007","unstructured":"He, L., He, X., Lim, L. P., de Stanchina, E., Xuan, Z., et al. (2007). A microRNA component of the p53 tumour suppressor network. Nature, 447, 1130\u20131134. doi: 10.1038\/nature05939 .","journal-title":"Nature"},{"key":"8063_CR42","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nature03552","volume":"435","author":"L He","year":"2005","unstructured":"He, L., Thomson, J. M., Hemann, M. T., Hernando-Monge, E., Mu, D., et al. (2005). A microRNA polycistron as a potential human oncogene. Nature, 435, 828\u2013833. doi: 10.1038\/nature03552 .","journal-title":"Nature"},{"key":"8063_CR43","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1073\/pnas.0710263105","volume":"105","author":"SS Hebert","year":"2008","unstructured":"Hebert, S. S., Horre, K., Nicolai, L., Papadopoulou, A. S., Mandemakers, W., et al. (2008). Loss of microRNA cluster miR-29a\/b-1 in sporadic Alzheimer\u2019s disease correlates with increased BACE1\/beta-secretase expression. Proceedings of the National Academy of Sciences of the United States of America, 105, 6415\u20136420. doi: 10.1073\/pnas.0710263105 .","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"8063_CR44","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0304-3940(91)90583-F","volume":"133","author":"JC Hedreen","year":"1991","unstructured":"Hedreen, J. C., Peyser, C. E., Folstein, S. E., & Ross, C. A. (1991). Neuronal loss in layers V and VI of cerebral cortex in Huntington\u2019s disease. Neuroscience Letters, 133, 257\u2013261. doi: 10.1016\/0304-3940(91)90583-F .","journal-title":"Neuroscience Letters"},{"key":"8063_CR45","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/hmg\/ddl013","volume":"15","author":"A Hodges","year":"2006","unstructured":"Hodges, A., Strand, A. D., Aragaki, A. K., Kuhn, A., Sengstag, T., et al. (2006). Regional and cellular gene expression changes in human Huntington\u2019s disease brain. Human Molecular Genetics, 15, 965\u2013977. doi: 10.1093\/hmg\/ddl013 .","journal-title":"Human Molecular Genetics"},{"key":"8063_CR46","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1023\/B:SCAM.0000007124.19463.e5","volume":"24","author":"CC Huang","year":"1998","unstructured":"Huang, C. C., Faber, P. W., Persichetti, F., Mittal, V., Vonsattel, J. P., et al. (1998). Amyloid formation by mutant huntingtin: Threshold, progressivity and recruitment of normal polyglutamine proteins. Somatic Cell and Molecular Genetics, 24, 217\u2013233. doi: 10.1023\/B:SCAM.0000007124.19463.e5 .","journal-title":"Somatic Cell and Molecular Genetics"},{"key":"8063_CR1","doi-asserted-by":"crossref","unstructured":"Huntington\u2019s Disease Collaborative Research Group. (1993). A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes. The Huntington\u2019s Disease Collaborative Research Group. Cell, 72, 971\u2013983. doi: 10.1016\/0092-8674(93)90585-E .","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"8063_CR47","doi-asserted-by":"crossref","first-page":"8031","DOI":"10.1038\/sj.onc.1206928","volume":"22","author":"P Ji","year":"2003","unstructured":"Ji, P., Diederichs, S., Wang, W., Boing, S., Metzger, R., et al. (2003). MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene, 22, 8031\u20138041. doi: 10.1038\/sj.onc.1206928 .","journal-title":"Oncogene"},{"key":"8063_CR48","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1093\/nar\/gkl525","volume":"34","author":"R Johnson","year":"2006","unstructured":"Johnson, R., Gamblin, R. J., Ooi, L., Bruce, A. W., Donaldson, I. J., et al. (2006). Identification of the REST regulon reveals extensive transposable element-mediated binding site duplication. Nucleic Acids Research, 34, 3862\u20133877. doi: 10.1093\/nar\/gkl525 .","journal-title":"Nucleic Acids Research"},{"key":"8063_CR49","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1126\/science.1141319","volume":"316","author":"D Johnson","year":"2007","unstructured":"Johnson, D., Mortazavi, A., Myers, R., & Wold, B. (2007). Genome-wide mapping of in vivo protein-DNA interactions. Science, 316, 1497\u20131502. doi: 10.1126\/science.1141319 .","journal-title":"Science"},{"key":"8063_CR50","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1261\/rna.1127009","volume":"15","author":"R Johnson","year":"2009","unstructured":"Johnson, R., Teh, C. H., Jia, H., Vanisri, R. R., Pandey, T., et al. (2009). Regulation of neural macroRNAs by the transcriptional repressor REST. RNA, 15, 85\u201396. doi: 10.1261\/rna.1127009 .","journal-title":"RNA"},{"key":"8063_CR51","doi-asserted-by":"crossref","first-page":"e256","DOI":"10.1371\/journal.pbio.0060256","volume":"6","author":"R Johnson","year":"2008","unstructured":"Johnson, R., Teh, C. H.-L., Kunarso, G., Wong, K. Y., Srinivasan, G., et al. (2008a). REST regulates distinct transcriptional networks in embryonic and neural stem cells. PLoS Biology, 6, e256. doi: 10.1371\/journal.pbio.0060256 .","journal-title":"PLoS Biology"},{"key":"8063_CR52","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.nbd.2007.11.001","volume":"29","author":"R Johnson","year":"2008","unstructured":"Johnson, R., Zuccato, C., Belyaev, N. D., Guest, D. J., Cattaneo, E., et al. (2008b). A microRNA-based gene dysregulation pathway in Huntington\u2019s disease. Neurobiology of Disease, 29, 438\u2013445. doi: 10.1016\/j.nbd.2007.11.001 .","journal-title":"Neurobiology of Disease"},{"key":"8063_CR53","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.cell.2007.09.020","volume":"131","author":"JS Karres","year":"2007","unstructured":"Karres, J. S., Hilgers, V., Carrera, I., Treisman, J., & Cohen, S. M. (2007). The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila. Cell, 131, 136\u2013145. doi: 10.1016\/j.cell.2007.09.020 .","journal-title":"Cell"},{"key":"8063_CR54","doi-asserted-by":"crossref","first-page":"7466","DOI":"10.1074\/jbc.M103946200","volume":"277","author":"KB Kegel","year":"2002","unstructured":"Kegel, K. B., Meloni, A. R., Yi, Y., Kim, Y. J., Doyle, E., et al. (2002). Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription. Journal of Biological Chemistry, 277, 7466\u20137476. doi: 10.1074\/jbc.M103946200 .","journal-title":"Journal of Biological Chemistry"},{"key":"8063_CR55","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1523\/JNEUROSCI.5667-07.2008","volume":"28","author":"MO Kim","year":"2008","unstructured":"Kim, M. O., Chawla, P., Overland, R. P., Xia, E., Sadri-Vakili, G., et al. (2008). Altered histone monoubiquitylation mediated by mutant huntingtin induces transcriptional dysregulation. Journal of Neuroscience, 28, 3947\u20133957. doi: 10.1523\/JNEUROSCI.5667-07.2008 .","journal-title":"Journal of Neuroscience"},{"key":"8063_CR56","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1126\/science.1140481","volume":"317","author":"J Kim","year":"2007","unstructured":"Kim, J., Inoue, K., Ishii, J., Vanti, W. B., Voronov, S. V., et al. (2007). A MicroRNA feedback circuit in midbrain dopamine neurons. Science, 317, 1220\u20131224. doi: 10.1126\/science.1140481 .","journal-title":"Science"},{"key":"8063_CR57","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/nrn2037","volume":"7","author":"KS Kosik","year":"2006","unstructured":"Kosik, K. S. (2006). The neuronal microRNA system. Nature Reviews Neuroscience, 7, 911\u2013920. doi: 10.1038\/nrn2037 .","journal-title":"Nature Reviews Neuroscience"},{"key":"8063_CR58","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1261\/rna.5980303","volume":"9","author":"AM Krichevsky","year":"2003","unstructured":"Krichevsky, A. M., King, K. S., Donahue, C. P., Khrapko, K., & Kosik, K. S. (2003). A microRNA array reveals extensive regulation of microRNAs during brain development. RNA, 9, 1274\u20131281. doi: 10.1261\/rna.5980303 .","journal-title":"RNA"},{"key":"8063_CR59","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1634\/stemcells.2005-0441","volume":"24","author":"AM Krichevsky","year":"2006","unstructured":"Krichevsky, A. M., Sonntag, K. C., Isacson, O., & Kosik, K. S. (2006). Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells, 24, 857\u2013864. doi: 10.1634\/stemcells.2005-0441 .","journal-title":"Stem Cells"},{"key":"8063_CR60","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1093\/hmg\/ddm133","volume":"16","author":"A Kuhn","year":"2007","unstructured":"Kuhn, A., Goldstein, D. R., Hodges, A., Strand, A. D., Sengstag, T., et al. (2007). Mutant huntingtin\u2019s effects on striatal gene expression in mice recapitulate changes observed in human Huntington\u2019s disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage. Human Molecular Genetics, 16, 1845\u20131861. doi: 10.1093\/hmg\/ddm133 .","journal-title":"Human Molecular Genetics"},{"key":"8063_CR61","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.cell.2007.04.040","volume":"129","author":"P Landgraf","year":"2007","unstructured":"Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., et al. (2007). A mammalian microRNA expression atlas based on small RNA library sequencing. Cell, 129, 1401\u20131414. doi: 10.1016\/j.cell.2007.04.040 .","journal-title":"Cell"},{"key":"8063_CR62","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0092-8674(00)80711-4","volume":"97","author":"R Lanz","year":"1999","unstructured":"Lanz, R., McKenna, N., Onate, S., Albrecht, U., Wong, J., et al. (1999). A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. Cell, 97, 17\u201327. doi: 10.1016\/S0092-8674(00)80711-4 .","journal-title":"Cell"},{"key":"8063_CR63","doi-asserted-by":"crossref","first-page":"5695","DOI":"10.1016\/j.bmc.2008.03.067","volume":"16","author":"S Leone","year":"2008","unstructured":"Leone, S., Mutti, C., Kazantsev, A., Sturlese, M., Moro, S., et al. (2008). SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington\u2019s disease. Bioorganic & Medicinal Chemistry, 16, 5695\u20135703. doi: 10.1016\/j.bmc.2008.03.067 .","journal-title":"Bioorganic & Medicinal Chemistry"},{"key":"8063_CR64","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nn.2115","volume":"11","author":"C Leucht","year":"2008","unstructured":"Leucht, C., Stigloher, C., Wizenmann, A., Klafke, R., Folchert, A., et al. (2008). MicroRNA-9 directs late organizer activity of the midbrain\u2013hindbrain boundary. Nature Neuroscience, 11, 641\u2013648. doi: 10.1038\/nn.2115 .","journal-title":"Nature Neuroscience"},{"key":"8063_CR65","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0092-8674(03)01018-3","volume":"115","author":"BP Lewis","year":"2003","unstructured":"Lewis, B. P., Shih, I. H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003). Prediction of mammalian microRNA targets. Cell, 115, 787\u2013798. doi: 10.1016\/S0092-8674(03)01018-3 .","journal-title":"Cell"},{"key":"8063_CR66","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nature03315","volume":"433","author":"LP Lim","year":"2005","unstructured":"Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., et al. (2005). Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature, 433, 769\u2013773. doi: 10.1038\/nature03315 .","journal-title":"Nature"},{"key":"8063_CR67","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00239-005-0041-3","volume":"62","author":"L Lipovich","year":"2006","unstructured":"Lipovich, L., Vanisri, R. R., Kong, S. L., Lin, C. Y., & Liu, E. T. (2006). Primate-specific endogenous cis-antisense transcription in the human 5q31 protocadherin gene cluster. Journal of Molecular Evolution, 62, 73\u201388. doi: 10.1007\/s00239-005-0041-3 .","journal-title":"Journal of Molecular Evolution"},{"key":"8063_CR68","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1741-7007-5-4","volume":"5","author":"R Louro","year":"2007","unstructured":"Louro, R., Nakaya, H. I., Amaral, P. P., Festa, F., Sogayar, M. C., et al. (2007). Androgen responsive intronic non-coding RNAs. BMC Biology, 5, 4. doi: 10.1186\/1741-7007-5-4 .","journal-title":"BMC Biology"},{"key":"8063_CR69","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature03702","volume":"435","author":"J Lu","year":"2005","unstructured":"Lu, J., Getz, G., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., et al. (2005). MicroRNA expression profiles classify human cancers. Nature, 435, 834\u2013838. doi: 10.1038\/nature03702 .","journal-title":"Nature"},{"key":"8063_CR70","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1093\/hmg\/11.17.1911","volume":"11","author":"R Luthi-Carter","year":"2002","unstructured":"Luthi-Carter, R., Hanson, S. A., Strand, A. D., Bergstrom, D. A., Chun, W., et al. (2002). Dysregulation of gene expression in the R6\/2 model of polyglutamine disease: parallel changes in muscle and brain. Human Molecular Genetics, 11, 1911\u20131926. doi: 10.1093\/hmg\/11.17.1911 .","journal-title":"Human Molecular Genetics"},{"key":"8063_CR71","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/hmg\/9.9.1259","volume":"9","author":"R Luthi-Carter","year":"2000","unstructured":"Luthi-Carter, R., Strand, A., Peters, N. L., Solano, S. M., Hollingsworth, Z. R., et al. (2000). Decreased expression of striatal signaling genes in a mouse model of Huntington\u2019s disease. Human Molecular Genetics, 9, 1259\u20131271. doi: 10.1093\/hmg\/9.9.1259 .","journal-title":"Human Molecular Genetics"},{"key":"8063_CR72","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.molcel.2007.07.015","volume":"27","author":"EV Makeyev","year":"2007","unstructured":"Makeyev, E. V., Zhang, J., Carrasco, M. A., & Maniatis, T. (2007). The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Molecular Cell, 27, 435\u2013448. doi: 10.1016\/j.molcel.2007.07.015 .","journal-title":"Molecular Cell"},{"key":"8063_CR73","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","volume":"87","author":"L Mangiarini","year":"1996","unstructured":"Mangiarini, L., Sathasivam, K., Seller, M., Cozens, B., Harper, A., et al. (1996). Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell, 87, 493\u2013506. doi: 10.1016\/S0092-8674(00)81369-0 .","journal-title":"Cell"},{"key":"8063_CR74","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.molcel.2007.12.013","volume":"29","author":"PD Mariner","year":"2008","unstructured":"Mariner, P. D., Walters, R. D., Espinoza, C. A., Drullinger, L. F., Wagner, S. D., et al. (2008). Human Alu RNA is a modular transacting repressor of mRNA transcription during heat shock. Molecular Cell, 29, 499\u2013509. doi: 10.1016\/j.molcel.2007.12.013 .","journal-title":"Molecular Cell"},{"key":"8063_CR75","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1093\/hmg\/9.14.2197","volume":"9","author":"A McCampbell","year":"2000","unstructured":"McCampbell, A., Taylor, J. P., Taye, A. A., Robitschek, J., Li, M., et al. (2000). CREB-binding protein sequestration by expanded polyglutamine. Human Molecular Genetics, 9, 2197\u20132202. doi: 10.1093\/hmg\/9.14.2197 .","journal-title":"Human Molecular Genetics"},{"key":"8063_CR76","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1152\/physrev.00036.2006","volume":"87","author":"MF Mehler","year":"2007","unstructured":"Mehler, M. F., & Mattick, J. S. (2007). Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological disease. Physiological Reviews, 87, 799\u2013823. doi: 10.1152\/physrev.00036.2006 .","journal-title":"Physiological Reviews"},{"key":"8063_CR77","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1016\/j.cub.2005.10.048","volume":"15","author":"G Meister","year":"2005","unstructured":"Meister, G., Landthaler, M., Peters, L., Chen, P. Y., Urlaub, H., et al. (2005). Identification of novel argonaute-associated proteins. Current Biology, 15, 2149\u20132155. doi: 10.1016\/j.cub.2005.10.048 .","journal-title":"Current Biology"},{"key":"8063_CR78","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1073\/pnas.0706729105","volume":"105","author":"TR Mercer","year":"2008","unstructured":"Mercer, T. R., Dinger, M. E., Sunkin, S. M., Mehler, M. F., & Mattick, J. S. (2008). Specific expression of long noncoding RNAs in the mouse brain. Proceedings of the National Academy of Sciences of the United States of America, 105, 716\u2013721. doi: 10.1073\/pnas.0706729105 .","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"8063_CR79","doi-asserted-by":"crossref","first-page":"R68","DOI":"10.1186\/gb-2004-5-9-r68","volume":"5","author":"EA Miska","year":"2004","unstructured":"Miska, E. A., Alvarez-Saavedra, E., Townsend, M., Yoshii, A., Sestan, N., et al. (2004). Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biology, 5, R68. doi: 10.1186\/gb-2004-5-9-r68 .","journal-title":"Genome Biology"},{"key":"8063_CR80","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1101\/gr.4997306","volume":"16","author":"A Mortazavi","year":"2006","unstructured":"Mortazavi, A., Thompson, E. C. L., Garcia, S. T., Myers, R. M., & Wold, B. (2006). Comparative genomics modeling of the NRSF\/REST repressor network: From single conserved sites to genome-wide repertoire. Genome Research, 16, 1208\u20131221. doi: 10.1101\/gr.4997306 .","journal-title":"Genome Research"},{"key":"8063_CR81","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nmeth.1226","volume":"5","author":"A Mortazavi","year":"2008","unstructured":"Mortazavi, A., Williams, B. A., McCue, K., Schaeffer, L., & Wold, B. (2008). Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nature Methods, 5, 621\u2013628. doi: 10.1038\/nmeth.1226 .","journal-title":"Nature Methods"},{"key":"8063_CR82","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1093\/hmg\/10.14.1441","volume":"10","author":"K Nakamura","year":"2001","unstructured":"Nakamura, K., Jeong, S. Y., Uchihara, T., Anno, M., Nagashima, K., et al. (2001). SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein. Human Molecular Genetics, 10, 1441\u20131448. doi: 10.1093\/hmg\/10.14.1441 .","journal-title":"Human Molecular Genetics"},{"key":"8063_CR83","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1093\/hmg\/ddn011","volume":"17","author":"T Nomura","year":"2008","unstructured":"Nomura, T., Kimura, M., Horii, T., Morita, S., Soejima, H., et al. (2008). MeCP2-dependent repression of an imprinted miR-184 released by depolarization. Human Molecular Genetics, 17, 1192\u20131199. doi: 10.1093\/hmg\/ddn011 .","journal-title":"Human Molecular Genetics"},{"key":"8063_CR84","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrg981","volume":"4","author":"MV Olson","year":"2003","unstructured":"Olson, M. V., & Varki, A. (2003). Sequencing the chimpanzee genome: insights into human evolution and disease. Nature Review. Genetics, 4, 20\u201328. doi: 10.1038\/nrg981 .","journal-title":"Nature Review. Genetics"},{"key":"8063_CR85","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nrg2100","volume":"8","author":"L Ooi","year":"2007","unstructured":"Ooi, L., & Wood, I. C. (2007). Chromatin crosstalk in development and disease: lessons from REST. Nature Reviews Genetics, 8, 544\u2013554. doi: 10.1038\/nrg2100 .","journal-title":"Nature Reviews Genetics"},{"key":"8063_CR86","doi-asserted-by":"crossref","first-page":"6729","DOI":"10.1523\/JNEUROSCI.0091-07.2007","volume":"27","author":"SJ Otto","year":"2007","unstructured":"Otto, S. J., McCorkle, S. R., Hover, J., Conaco, C., Han, J.-J., et al. (2007). A new binding motif for the transcriptional repressor rest uncovers large gene networks devoted to neuronal functions. Journal of Neuroscience, 27, 6729\u20136739. doi: 10.1523\/JNEUROSCI.0091-07.2007 .","journal-title":"Journal of Neuroscience"},{"key":"8063_CR87","doi-asserted-by":"crossref","first-page":"14341","DOI":"10.1523\/JNEUROSCI.2390-08.2008","volume":"28","author":"AN Packer","year":"2008","unstructured":"Packer, A. N., Xing, Y., Harper, S. Q., Jones, L., & Davidson, B. L. (2008). The bifunctional microRNA miR-9\/miR-9* regulates REST and CoREST and is downregulated in Huntington\u2019s disease. Journal of Neuroscience, 28, 14341\u201314346. doi: 10.1523\/JNEUROSCI.2390-08.2008 .","journal-title":"Journal of Neuroscience"},{"key":"8063_CR88","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1523\/JNEUROSCI.18-04-01280.1998","volume":"18","author":"K Palm","year":"1998","unstructured":"Palm, K., Belluardo, N., Metsis, M., & To, Timmusk. (1998). Neuronal expression of zinc finger transcription factor REST\/NRSF\/XBR gene. Journal of Neuroscience, 18, 1280\u20131296.","journal-title":"Journal of Neuroscience"},{"key":"8063_CR89","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.molcel.2008.08.022","volume":"32","author":"RR Pandey","year":"2008","unstructured":"Pandey, R. R., Mondal, T., Mohammad, F., Enroth, S., Redrup, L., et al. (2008). Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation. Molecular Cell, 32, 232\u2013246. doi: 10.1016\/j.molcel.2008.08.022 .","journal-title":"Molecular Cell"},{"key":"8063_CR90","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1750-1326-3-10","volume":"3","author":"N Patel","year":"2008","unstructured":"Patel, N., Hoang, D., Miller, N., Ansaloni, S., Huang, Q., et al. (2008). MicroRNAs can regulate human APP levels. Molecular Neurodegeneration, 3, 10. doi: 10.1186\/1750-1326-3-10 .","journal-title":"Molecular Neurodegeneration"},{"key":"8063_CR91","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/hmg\/ddm336","volume":"17","author":"DS Perez","year":"2008","unstructured":"Perez, D. S., Hoage, T. R., Pritchett, J. R., Ducharme-Smith, A. L., Halling, M. L., et al. (2008). Long, abundantly expressed non-coding transcripts are altered in cancer. Human Molecular Genetics, 17, 642\u2013655. doi: 10.1093\/hmg\/ddm336 .","journal-title":"Human Molecular Genetics"},{"key":"8063_CR92","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nature05113","volume":"443","author":"KS Pollard","year":"2006","unstructured":"Pollard, K. S., Salama, S. R., Lambert, N., Lambot, M.-A., Coppens, S., et al. (2006). An RNA gene expressed during cortical development evolved rapidly in humans. Nature, 443, 167\u2013172. doi: 10.1038\/nature05113 .","journal-title":"Nature"},{"key":"8063_CR93","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1101\/gr.6036807","volume":"17","author":"J Ponjavic","year":"2007","unstructured":"Ponjavic, J., Ponting, C. P., & Lunter, G. (2007). Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs. Genome Research, 17, 556\u2013565. doi: 10.1101\/gr.6036807 .","journal-title":"Genome Research"},{"key":"8063_CR94","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1126\/science.1164096","volume":"322","author":"P Preker","year":"2008","unstructured":"Preker, P., Nielsen, J., Kammler, S., Lykke-Andersen, S., Christensen, M. S., et al. (2008). RNA exosome depletion reveals transcription upstream of active human promoters. Science, 322, 1851\u20131854. doi: 10.1126\/science.1164096 .","journal-title":"Science"},{"key":"8063_CR95","doi-asserted-by":"crossref","first-page":"16672","DOI":"10.1074\/jbc.M511648200","volume":"281","author":"Z Qiu","year":"2006","unstructured":"Qiu, Z., Norflus, F., Singh, B., Swindell, M. K., Buzescu, R., et al. (2006). Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective. Journal of Biological Chemistry, 281, 16672\u201316680. doi: 10.1074\/jbc.M511648200 .","journal-title":"Journal of Biological Chemistry"},{"key":"8063_CR96","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.ydbio.2003.12.003","volume":"267","author":"N Rajewsky","year":"2004","unstructured":"Rajewsky, N., & Socci, N. D. (2004). Computational identification of microRNA targets. Developmental Biology, 267, 529\u2013535. doi: 10.1016\/j.ydbio.2003.12.003 .","journal-title":"Developmental Biology"},{"key":"8063_CR97","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1101\/gr.4200206","volume":"16","author":"T Ravasi","year":"2006","unstructured":"Ravasi, T., Suzuki, H., Pang, K. C., Katayama, S., Furuno, M., et al. (2006). Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome. Genome Research, 16, 11\u201319. doi: 10.1101\/gr.4200206 .","journal-title":"Genome Research"},{"key":"8063_CR98","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.1073\/pnas.85.15.5733","volume":"85","author":"A Reiner","year":"1988","unstructured":"Reiner, A., Albin, R. L., Anderson, K. D., D\u2019Amato, C. J., Penney, J. B., et al. (1988). Differential loss of striatal projection neurons in Huntington disease. Proceedings of the National Academy of Sciences of the United States of America, 85, 5733\u20135737. doi: 10.1073\/pnas.85.15.5733 .","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"8063_CR99","doi-asserted-by":"crossref","first-page":"24554","DOI":"10.1074\/jbc.M609885200","volume":"282","author":"D Rigamonti","year":"2007","unstructured":"Rigamonti, D., Bolognini, D., Mutti, C., Zuccato, C., Tartari, M., et al. (2007). Loss of huntingtin function complemented by small molecules acting as repressor element 1\/neuron restrictive silencer element silencer modulators. Journal of Biological Chemistry, 282, 24554\u201324562. doi: 10.1074\/jbc.M609885200 .","journal-title":"Journal of Biological Chemistry"},{"key":"8063_CR100","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.cell.2007.05.022","volume":"127","author":"J Rinn","year":"2007","unstructured":"Rinn, J., Kertesz, M., Wang, J., Squazzo, S., Xu, X., et al. (2007). Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell, 127, 1311\u20131323. doi: 10.1016\/j.cell.2007.05.022 .","journal-title":"Cell"},{"key":"8063_CR101","doi-asserted-by":"crossref","first-page":"14424","DOI":"10.1073\/pnas.0703652104","volume":"104","author":"H Runne","year":"2007","unstructured":"Runne, H., Kuhn, A., Wild, E. J., Pratyaksha, W., Kristiansen, M., et al. (2007). Analysis of potential transcriptomic biomarkers for Huntington\u2019s disease in peripheral blood. Proceedings of the National Academy of Sciences of the United States of America, 104, 14424\u201314429. doi: 10.1073\/pnas.0703652104 .","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"8063_CR102","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1126\/science.1066315","volume":"294","author":"G Ruvkun","year":"2001","unstructured":"Ruvkun, G. (2001). Molecular biology. Glimpses of a tiny RNA world. Science, 294, 797\u2013799. doi: 10.1126\/science.1066315 .","journal-title":"Science"},{"key":"8063_CR103","doi-asserted-by":"crossref","first-page":"e3652","DOI":"10.1371\/journal.pone.0003652","volume":"3","author":"R Saba","year":"2008","unstructured":"Saba, R., Goodman, C. D., Huzarewich, R. L., Robertson, C., & Booth, S. A. (2008). A miRNA signature of prion induced neurodegeneration. PLoS ONE, 3, e3652. doi: 10.1371\/journal.pone.0003652 .","journal-title":"PLoS ONE"},{"key":"8063_CR104","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1093\/hmg\/ddm078","volume":"16","author":"G Sadri-Vakili","year":"2007","unstructured":"Sadri-Vakili, G., Bouzou, B., Benn, C. L., Kim, M. O., Chawla, P., et al. (2007). Histones associated with downregulated genes are hypo-acetylated in Huntington\u2019s disease models. Human Molecular Genetics, 16, 1293\u20131306. doi: 10.1093\/hmg\/ddm078 .","journal-title":"Human Molecular Genetics"},{"key":"8063_CR105","doi-asserted-by":"crossref","first-page":"10820","DOI":"10.1073\/pnas.0800658105","volume":"105","author":"JN Savas","year":"2008","unstructured":"Savas, J. N., Makusky, A., Ottosen, S., Baillat, D., Then, F., et al. (2008). Huntington\u2019s disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies. Proceedings of the National Academy of Sciences of the United States of America, 105, 10820\u201310825. doi: 10.1073\/pnas.0800658105 .","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"8063_CR106","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1084\/jem.20070823","volume":"204","author":"A Schaefer","year":"2007","unstructured":"Schaefer, A., O\u2019Carroll, D., Tan, C. L., Hillman, D., Sugimori, M., et al. (2007). Cerebellar neurodegeneration in the absence of microRNAs. Journal of Experimental Medicine, 204, 1553\u20131558. doi: 10.1084\/jem.20070823 .","journal-title":"Journal of Experimental Medicine"},{"key":"8063_CR107","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1126\/science.7871435","volume":"5202","author":"C Schoenherr","year":"1995","unstructured":"Schoenherr, C., & Anderson, D. (1995). The neuron-restrictive silencer factor (NRSF): A coordinate repressor of multiple neuron-specific genes. Science, 5202, 1360\u20131363. doi: 10.1126\/science.7871435 .","journal-title":"Science"},{"key":"8063_CR108","doi-asserted-by":"crossref","first-page":"9881","DOI":"10.1073\/pnas.93.18.9881","volume":"93","author":"CJ Schoenherr","year":"1996","unstructured":"Schoenherr, C. J., Paquette, A. J., & Anderson, D. J. (1996). Identification of potential target genes for the neuron-restrictive silencer factor. Proceedings of the National Academy of Sciences, 93, 9881\u20139886. doi: 10.1073\/pnas.93.18.9881 .","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"8063_CR109","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nature04367","volume":"439","author":"GM Schratt","year":"2006","unstructured":"Schratt, G. M., Tuebing, F., Nigh, E. A., Kane, C. G., Sabatini, M. E., et al. (2006). A brain-specific microRNA regulates dendritic spine development. Nature, 439, 283\u2013289. doi: 10.1038\/nature04367 .","journal-title":"Nature"},{"key":"8063_CR110","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1186\/gb-2004-5-3-r13","volume":"5","author":"LF Sempere","year":"2004","unstructured":"Sempere, L. F., Freemantle, S., Pitha-Rowe, I., Moss, E., Dmitrovsky, E., et al. (2004). Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biology, 5, R13. doi: 10.1186\/gb-2004-5-3-r13 .","journal-title":"Genome Biology"},{"key":"8063_CR111","doi-asserted-by":"crossref","first-page":"10415","DOI":"10.1523\/JNEUROSCI.3219-08.2008","volume":"28","author":"M Shibata","year":"2008","unstructured":"Shibata, M., Kurokawa, D., Nakao, H., Ohmura, T., & Aizawa, S. (2008). MicroRNA-9 modulates Cajal\u2013Retzius cell differentiation by suppressing Foxg1 expression in mouse medial pallium. Journal of Neuroscience, 28, 10415\u201310421. doi: 10.1523\/JNEUROSCI.3219-08.2008 .","journal-title":"Journal of Neuroscience"},{"key":"8063_CR112","doi-asserted-by":"crossref","first-page":"34880","DOI":"10.1074\/jbc.M804183200","volume":"283","author":"M Shimojo","year":"2008","unstructured":"Shimojo, M. (2008). Huntingtin regulates RE1-silencing transcription factor\/neuron-restrictive silencer factor (REST\/NRSF) nuclear trafficking indirectly through a complex with REST\/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued. Journal of Biological Chemistry, 283, 34880\u201334886. doi: 10.1074\/jbc.M804183200 .","journal-title":"Journal of Biological Chemistry"},{"key":"8063_CR113","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1111\/j.1460-9568.2005.03978.x","volume":"21","author":"L Smirnova","year":"2005","unstructured":"Smirnova, L., Grafe, A., Seiler, A., Schumacher, S., Nitsch, R., et al. (2005). Regulation of miRNA expression during neural cell specification. European Journal of Neuroscience, 21, 1469\u20131477. doi: 10.1111\/j.1460-9568.2005.03978.x .","journal-title":"European Journal of Neuroscience"},{"key":"8063_CR114","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ng0893-393","volume":"4","author":"RG Snell","year":"1993","unstructured":"Snell, R. G., MacMillan, J. C., Cheadle, J. P., Fenton, I., Lazarou, L. P., et al. (1993). Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington\u2019s disease. Nature Genetics, 4, 393\u2013397. doi: 10.1038\/ng0893-393 .","journal-title":"Nature Genetics"},{"key":"8063_CR115","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1073\/pnas.0511045103","volume":"103","author":"P Sood","year":"2006","unstructured":"Sood, P., Krek, A., Zavolan, M., Macino, G., & Rajewsky, N. (2006). Cell-type-specific signatures of microRNAs on target mRNA expression. PNAS, 103, 2746\u20132751. doi: 10.1073\/pnas.0511045103 .","journal-title":"PNAS"},{"key":"8063_CR116","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/ng.138","volume":"40","author":"KL Stark","year":"2008","unstructured":"Stark, K. L., Xu, B., Bagchi, A., Lai, W. S., Liu, H., et al. (2008). Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nature Genetics, 40, 751\u2013760. doi: 10.1038\/ng.138 .","journal-title":"Nature Genetics"},{"key":"8063_CR117","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1073\/pnas.100110097","volume":"97","author":"JS Steffan","year":"2000","unstructured":"Steffan, J. S., Kazantsev, A., Spasic-Boskovic, O., Greenwald, M., Zhu, Y.-Z., et al. (2000). The Huntington\u2019s disease protein interacts with p53 and CREB-binding protein and represses transcription. PNAS, 97, 6763\u20136768. doi: 10.1073\/pnas.100110097 .","journal-title":"PNAS"},{"key":"8063_CR118","doi-asserted-by":"crossref","first-page":"11758","DOI":"10.1523\/JNEUROSCI.2461-07.2007","volume":"27","author":"AD Strand","year":"2007","unstructured":"Strand, A. D., Baquet, Z. C., Aragaki, A. K., Holmans, P., Yang, L., et al. (2007). Expression profiling of Huntington\u2019s disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration. Journal of Neuroscience, 27, 11758\u201311768. doi: 10.1523\/JNEUROSCI.2461-07.2007 .","journal-title":"Journal of Neuroscience"},{"key":"8063_CR119","doi-asserted-by":"crossref","first-page":"5630","DOI":"10.1091\/mbc.e05-07-0687","volume":"16","author":"Y-M Sun","year":"2005","unstructured":"Sun, Y.-M., Greenway, D. J., Johnson, R., Street, M., Belyaev, N. D., et al. (2005). Distinct profiles of REST interactions with its target genes at different stages of neuronal development. Molecular Biology of the Cell, 16, 5630\u20135638. doi: 10.1091\/mbc.E05-07-0687 .","journal-title":"Molecular Biology of the Cell"},{"key":"8063_CR120","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.bbrc.2008.05.127","volume":"372","author":"S Tochitani","year":"2008","unstructured":"Tochitani, S., & Hayashizaki, Y. (2008). Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation. Biochemical and Biophysical Research Communications, 372, 691\u2013696. doi: 10.1016\/j.bbrc.2008.05.127 .","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"8063_CR121","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1101\/gr.3737405","volume":"15","author":"A Varki","year":"2005","unstructured":"Varki, A., & Altheide, T. K. (2005). Comparing the human and chimpanzee genomes: searching for needles in a haystack. Genome Research, 15, 1746\u20131758. doi: 10.1101\/gr.3737405 .","journal-title":"Genome Research"},{"key":"8063_CR122","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1101\/gad.1519107","volume":"21","author":"J Visvanathan","year":"2007","unstructured":"Visvanathan, J., Lee, S., Lee, B., Lee, J. W., & Lee, S. K. (2007). The microRNA miR-124 antagonizes the anti-neural REST\/SCP1 pathway during embryonic CNS development. Genes and Development, 21, 744\u2013749. doi: 10.1101\/gad.1519107 .","journal-title":"Genes and Development"},{"key":"8063_CR123","doi-asserted-by":"crossref","first-page":"16426","DOI":"10.1073\/pnas.0508448102","volume":"102","author":"N Vo","year":"2005","unstructured":"Vo, N., Klein, M. E., Varlamova, O., Keller, D. M., Yamamoto, T., et al. (2005). From the cover: A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. PNAS, 102, 16426\u201316431. doi: 10.1073\/pnas.0508448102 .","journal-title":"PNAS"},{"key":"8063_CR124","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00005072-199805000-00001","volume":"57","author":"JP Vonsattel","year":"1998","unstructured":"Vonsattel, J. P., & DiFiglia, M. (1998). Huntington disease. Journal of Neuropathology and Experimental Neurology, 57, 369\u2013384. doi: 10.1097\/00005072-199805000-00001 .","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"key":"8063_CR125","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","volume":"369","author":"FO Walker","year":"2007","unstructured":"Walker, F. O. (2007). Huntington\u2019s disease. Lancet, 369, 218\u2013228. doi: 10.1016\/S0140-6736(07)60111-1 .","journal-title":"Lancet"},{"key":"8063_CR126","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1523\/JNEUROSCI.5065-07.2008","volume":"28","author":"WX Wang","year":"2008","unstructured":"Wang, W. X., Rajeev, B. W., Stromberg, A. J., Ren, N., Tang, G., et al. (2008). The expression of microRNA miR-107 decreases early in Alzheimer\u2019s disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. Journal of Neuroscience, 28, 1213\u20131223. doi: 10.1523\/JNEUROSCI.5065-07.2008 .","journal-title":"Journal of Neuroscience"},{"key":"8063_CR127","doi-asserted-by":"crossref","first-page":"9093","DOI":"10.1073\/pnas.0803072105","volume":"105","author":"GA Wayman","year":"2008","unstructured":"Wayman, G. A., Davare, M., Ando, H., Fortin, D., Varlamova, O., et al. (2008). An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proceedings of the National Academy of Sciences of the United States of America, 105, 9093\u20139098. doi: 10.1073\/pnas.0803072105 .","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"8063_CR128","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/hmg\/8.1.115","volume":"8","author":"VC Wheeler","year":"1999","unstructured":"Wheeler, V. C., Auerbach, W., White, J. K., Srinidhi, J., Auerbach, A., et al. (1999). Length-dependent gametic CAG repeat instability in the Huntington\u2019s disease knock-in mouse. Human Molecular Genetics, 8, 115\u2013122. doi: 10.1093\/hmg\/8.1.115 .","journal-title":"Human Molecular Genetics"},{"key":"8063_CR129","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1126\/science.1115901","volume":"309","author":"A Willingham","year":"2005","unstructured":"Willingham, A., Orth, A., Batalov, S., Peters, E., Wen, B., et al. (2005). A strategy for probing the function of noncoding RNAs finds a repressor of NFAT. Science, 309, 1570\u20131573. doi: 10.1126\/science.1115901 .","journal-title":"Science"},{"key":"8063_CR130","doi-asserted-by":"crossref","first-page":"R85","DOI":"10.1186\/gb-2006-7-9-r85","volume":"7","author":"J Wu","year":"2006","unstructured":"Wu, J., & Xie, X. (2006). Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression. Genome Biology, 7, R85. doi: 10.1186\/gb-2006-7-9-r85 .","journal-title":"Genome Biology"},{"key":"8063_CR131","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1016\/j.yexcr.2008.06.002","volume":"314","author":"JY Yu","year":"2008","unstructured":"Yu, J. Y., Chung, K. H., Deo, M., Thompson, R. C., & Turner, D. L. (2008). MicroRNA miR-124 regulates neurite outgrowth during neuronal differentiation. Experimental Cell Research, 314, 2618\u20132633. doi: 10.1016\/j.yexcr.2008.06.002 .","journal-title":"Experimental Cell Research"},{"key":"8063_CR132","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1074\/mcp.M200016-MCP200","volume":"1","author":"C Zabel","year":"2002","unstructured":"Zabel, C., Chamrad, D. C., Priller, J., Woodman, B., Meyer, H. E., et al. (2002). Alterations in the mouse and human proteome caused by Huntington\u2019s disease. Molecular & Cellular Proteomics, 1, 366\u2013375. doi: 10.1074\/mcp.M200016-MCP200 .","journal-title":"Molecular & Cellular Proteomics"},{"key":"8063_CR133","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1101\/gad.1543507","volume":"21","author":"T Zhao","year":"2007","unstructured":"Zhao, T., Li, G., Mi, S., Li, S., Hannon, G. J., et al. (2007a). A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii. Genes and Development, 21, 1190\u20131203. doi: 10.1101\/gad.1543507 .","journal-title":"Genes and Development"},{"key":"8063_CR134","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cell.2007.03.030","volume":"129","author":"Y Zhao","year":"2007","unstructured":"Zhao, Y., Ransom, J. F., Li, A., Vedantham, V., von Drehle, M., et al. (2007b). Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell, 129, 303\u2013317. doi: 10.1016\/j.cell.2007.03.030 .","journal-title":"Cell"},{"key":"8063_CR135","doi-asserted-by":"crossref","first-page":"6972","DOI":"10.1523\/JNEUROSCI.4278-06.2007","volume":"27","author":"C Zuccato","year":"2007","unstructured":"Zuccato, C., Belyaev, N., Conforti, P., Ooi, L., Tartari, M., et al. (2007). Widespread disruption of repressor element-1 silencing transcription factor\/neuron-restrictive silencer factor occupancy at its target genes in huntington\u2019s disease. Journal of Neuroscience, 27, 6972\u20136983. doi: 10.1523\/JNEUROSCI.4278-06.2007 .","journal-title":"Journal of Neuroscience"},{"key":"8063_CR136","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.pneurobio.2007.01.003","volume":"81","author":"C Zuccato","year":"2007","unstructured":"Zuccato, C., & Cattaneo, E. (2007). Role of brain-derived neurotrophic factor in Huntington\u2019s disease. Progress in Neurobiology, 81, 294\u2013330. doi: 10.1016\/j.pneurobio.2007.01.003 .","journal-title":"Progress in Neurobiology"},{"key":"8063_CR137","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1126\/science.1059581","volume":"293","author":"C Zuccato","year":"2001","unstructured":"Zuccato, C., Ciammola, A., Rigamonti, D., Leavitt, B. R., Goffredo, D., et al. (2001). Loss of huntingtin-mediated BDNF gene transcription in Huntington\u2019s disease. Science, 293, 493\u2013498. doi: 10.1126\/science.1059581 .","journal-title":"Science"},{"key":"8063_CR138","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/ng1219","volume":"35","author":"C Zuccato","year":"2003","unstructured":"Zuccato, C., Tartari, M., Crotti, A., Goffredo, D., Valenza, M., et al. (2003). Huntingtin interacts with REST\/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nature Genetics, 35, 76\u201383. doi: 10.1038\/ng1219 .","journal-title":"Nature Genetics"}],"container-title":["NeuroMolecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-009-8063-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12017-009-8063-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-009-8063-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T01:49:05Z","timestamp":1559440145000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12017-009-8063-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,21]]},"references-count":138,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["8063"],"URL":"https:\/\/doi.org\/10.1007\/s12017-009-8063-4","relation":{},"ISSN":["1535-1084","1559-1174"],"issn-type":[{"value":"1535-1084","type":"print"},{"value":"1559-1174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,21]]}}}