{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:44:20Z","timestamp":1773272660914,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,8,19]],"date-time":"2012-08-19T00:00:00Z","timestamp":1345334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuromol Med"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1007\/s12017-012-8196-8","type":"journal-article","created":{"date-parts":[[2012,8,18]],"date-time":"2012-08-18T07:50:26Z","timestamp":1345276226000},"page":"74-81","source":"Crossref","is-referenced-by-count":20,"title":["RVG-Mediated Calpain2 Gene Silencing in the Brain Impairs Learning and Memory"],"prefix":"10.1007","volume":"15","author":[{"given":"Sohila","family":"Zadran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garnik","family":"Akopian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Homera","family":"Zadran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Baudry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,8,19]]},"reference":[{"issue":"2","key":"8196_CR1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1527-3458.2006.00135.x","volume":"12","author":"A Camins","year":"2006","unstructured":"Camins, A., Verdaguer, E., Folch, J., & Pall\u00e0s, M. (2006). Involvement of calpain activation in neurodegenerative processes. CNS Drug Reviews, 12(2), 135\u2013148.","journal-title":"CNS Drug Reviews"},{"issue":"1","key":"8196_CR2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/(SICI)1097-4547(19991001)58:1<167::AID-JNR16>3.0.CO;2-K","volume":"58","author":"SL Chan","year":"1999","unstructured":"Chan, S. L., & Mattson, M. P. (1999). Caspase and calpain substrates: Roles in synaptic plasticity and cell death. Journal of Neuroscience Research, 58(1), 167\u2013190.","journal-title":"Journal of Neuroscience Research"},{"key":"8196_CR3","doi-asserted-by":"crossref","first-page":"5363","DOI":"10.1523\/JNEUROSCI.0164-07.2007","volume":"20","author":"LY Chen","year":"2007","unstructured":"Chen, L. Y., Rex, C. S., Casale, M. S., Gall, C. M., & Lynch, G. (2007). Changes in synaptic morphology accompany actin signaling during LTP. Journal of Neuroscience, 20, 5363\u20135372.","journal-title":"Journal of Neuroscience"},{"issue":"17","key":"8196_CR5","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1007\/s00018-005-5097-0","volume":"62","author":"A Czogalla","year":"2005","unstructured":"Czogalla, A., & Sikorski, A. F. (2005). Spectrin and calpain: A \u2018target\u2019 and a \u2018sniper\u2019 in the pathology of neuronal cells. Cellular and Molecular Life Sciences, 62(17), 1913\u20131924. (Review).","journal-title":"Cellular and Molecular Life Sciences"},{"key":"8196_CR6","doi-asserted-by":"crossref","unstructured":"Demarchi, F., & Schneider, C. (2007). The calpain system as a modulator of stress\/damage response. Cell Cycle, 6(2), 136\u20138. (Epub 2007 Jan 27. Review).","DOI":"10.4161\/cc.6.2.3759"},{"key":"8196_CR7","doi-asserted-by":"crossref","unstructured":"Donkor I. O. (2011). Calpain inhibitors: A survey of compounds reported in the patent and scientific literature. Expert Opinion on Therapeutic Patents, 21(5), 601\u201336. (Epub 2011 Mar 24. Review).","DOI":"10.1517\/13543776.2011.568480"},{"key":"8196_CR9","doi-asserted-by":"crossref","unstructured":"Farr, C., & Berger, S. (2010). Measuring calpain activity in fixed and living cells by flow cytometry. Journal of Visualized Experiments, (41). doi: 10.3791\/2050 .","DOI":"10.3791\/2050"},{"key":"8196_CR10","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1152\/physrev.00029.2002","volume":"3","author":"DE Goll","year":"2003","unstructured":"Goll, D. E., Thompson, V. F., Li, H., Wei, W., & Cong, J. (2003). The calpain system. Physiological Reviews, 3, 731.","journal-title":"Physiological Reviews"},{"key":"8196_CR11","first-page":"222","volume":"3","author":"M Grammer","year":"2003","unstructured":"Grammer, M., Kuchay, S., Chisht, A., & Baudry, M. (2003). Lack of phenotype for LTP and fear conditioning learning in calpain 1 knock-out mice. Neurobiology of Learning and Memory, 3, 222\u2013227.","journal-title":"Neurobiology of Learning and Memory"},{"key":"8196_CR12","doi-asserted-by":"crossref","unstructured":"Greget, R., Pernot, F., Bouteiller, J. M., Ghaderi, V., Allam, S., Keller, A. F., Ambert, N., Legendre, A., Sarmis, M., Haeberle, O., Faupel, M., Bischoff, S., Berger, T. W., Baudry, M. (2011). Simulation of postsynaptic glutamate receptors reveals critical features of glutamatergic transmission. PLoS One, 6(12), e28380. (Epub 2011 Dec 15).","DOI":"10.1371\/journal.pone.0028380"},{"issue":"8","key":"8196_CR13","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S1471-4914(01)02049-4","volume":"7","author":"Y Huang","year":"2001","unstructured":"Huang, Y., & Wang, K. K. (2001). The calpain family and human disease. Trends in Molecular Medicine, 7(8), 355\u2013362. (Review).","journal-title":"Trends in Molecular Medicine"},{"key":"8196_CR14","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511614125","volume-title":"Molecular reaction dynamics","author":"RD Levine","year":"2005","unstructured":"Levine, R. D. (2005). Molecular reaction dynamics. Cambridge, UK: Cambridge University Press."},{"key":"8196_CR15","unstructured":"Liu, J., Liu, M. C., & Wang, K. K. (2008). Calpain in the CNS: From synaptic function to neurotoxicity. Science Signal, (14):re1 (Review)."},{"key":"8196_CR18","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.6144182","volume":"224","author":"G Lynch","year":"1984","unstructured":"Lynch, G., & Baudry, M. (1984). The biochemistry of memory: A new and specific hypothesis. Science, 224, 1057\u20131063.","journal-title":"Science"},{"issue":"4","key":"8196_CR20","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3109\/1061186X.2012.669526","volume":"20","author":"S Rohn","year":"2012","unstructured":"Rohn, S., Suttkus, A., Arendt, T., & Ueberham, U. (2012). RVG peptide as transfection reagent for specific cdk4 gene silencing in vitro and in vivo. Journal of Drug Targeting, 20(4), 381\u2013388.","journal-title":"Journal of Drug Targeting"},{"issue":"6","key":"8196_CR22","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2183\/pjab.87.287","volume":"87","author":"H Sorimachi","year":"2011","unstructured":"Sorimachi, H., Hata, S., & Ono, Y. (2011). Calpain chronicle\u2014An enzyme family under multidisciplinary characterization. Proceedings of the Japan Academy. Series B, Physical and biological sciences, 87(6), 287\u2013327.","journal-title":"Proceedings of the Japan Academy. Series B, Physical and biological sciences"},{"key":"8196_CR23","doi-asserted-by":"crossref","unstructured":"Stockholm D, Bartoli M, Sillon G, Bourg N, Davoust J, Richard I. (2005). Imaging calpain protease activity by multiphoton FRET in living mice. Journal of Molecular Biology, 346(1), 215\u201322. (Epub 2004 Dec 16).","DOI":"10.1016\/j.jmb.2004.11.039"},{"issue":"19","key":"8196_CR24","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1128\/MCB.05189-11","volume":"31","author":"J Takano","year":"2011","unstructured":"Takano, J., Mihjra, N., Fujioka, R., Hosoki, E., Chishti, A. H., & Saido, T. C. (2011). Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival. Molecular and Cellular Biology, 31(19), 4097\u20134106.","journal-title":"Molecular and Cellular Biology"},{"issue":"1","key":"8196_CR25","first-page":"139","volume":"13","author":"MA Verity","year":"1992","unstructured":"Verity, M. A. (1992). Ca(2+)-dependent processes as mediators of neurotoxicity. Neurotoxicology, 13(1), 139\u2013147. Review.","journal-title":"Neurotoxicology"},{"key":"8196_CR26","doi-asserted-by":"crossref","unstructured":"Vosler, P. S., Brennan, C. S., Chen, J. (2008). Calpain-mediated signaling mechanisms in neuronal injury and neurodegeneration. Molecular Neurobiology, 38(1), 78\u2013100. (Epub 2008 Aug 7. Review).","DOI":"10.1007\/s12035-008-8036-x"},{"key":"8196_CR27","doi-asserted-by":"crossref","unstructured":"Zadran S., Bi X., & Baudry M. (2010a). Regulation of calpain-2 in neurons: Implications for synaptic plasticity. Molecular Neurobiology, 42(2), 143\u201350. (Epub 2010 Oct 6. Review).","DOI":"10.1007\/s12035-010-8145-1"},{"key":"8196_CR28","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1523\/JNEUROSCI.5120-09.2010","volume":"3","author":"S Zadran","year":"2010","unstructured":"Zadran, S., Jourdi, H., Rostamiani, K., Qin, Q., Bi, X., & Baudry, M. (2010b). Brain-derived neurotrophic factor and epidermal growth factor activate neuronal m-calpain via mitogen-activated protein kinase-dependent phosphorylation. Journal of Neuroscience, 3, 1086\u20131095.","journal-title":"Journal of Neuroscience"},{"key":"8196_CR29","doi-asserted-by":"crossref","first-page":"21936","DOI":"10.1073\/pnas.0912558106","volume":"51","author":"S Zadran","year":"2009","unstructured":"Zadran, S., Qin, Q., Bi, X., Zadran, H., Kim, Y., Foy, M. R., et al. (2009). 17-\u03b2-Estradiol increases neuronal excitability through MAP kinase-induced calpain activation. Proceedings of the National Academy of Sciences of the United States of America, 51, 21936\u201321941.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"}],"container-title":["NeuroMolecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-012-8196-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12017-012-8196-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-012-8196-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T23:30:52Z","timestamp":1562110252000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12017-012-8196-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,19]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["8196"],"URL":"https:\/\/doi.org\/10.1007\/s12017-012-8196-8","relation":{},"ISSN":["1535-1084","1559-1174"],"issn-type":[{"value":"1535-1084","type":"print"},{"value":"1559-1174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,19]]}}}