{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T08:10:45Z","timestamp":1763367045215,"version":"3.40.4"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,11,30]],"date-time":"2013-11-30T00:00:00Z","timestamp":1385769600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuromol Med"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1007\/s12017-013-8282-6","type":"journal-article","created":{"date-parts":[[2013,11,29]],"date-time":"2013-11-29T10:39:11Z","timestamp":1385721551000},"page":"308-321","source":"Crossref","is-referenced-by-count":27,"title":["Blockade of Nav1.8 Currents in Nociceptive Trigeminal Neurons Contributes to Anti-trigeminovascular Nociceptive Effect of Amitriptyline"],"prefix":"10.1007","volume":"16","author":[{"given":"Jingyao","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiyan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruozhuo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianquan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengyuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,11,30]]},"reference":[{"issue":"Suppl 1","key":"8282_CR1","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1007\/s10072-012-1034-9","volume":"33","author":"M Aguggia","year":"2012","unstructured":"Aguggia, M. (2012). Allodynia and migraine. Neurological Science, 33(Suppl 1), S9\u2013S11.","journal-title":"Neurological Science"},{"issue":"6","key":"8282_CR2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/9195","volume":"2","author":"AN Akopian","year":"1999","unstructured":"Akopian, A. N., Souslova, V., England, S., Okuse, K., Ogata, N., Ure, J., et al. (1999). The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nature Neuroscience, 2(6), 541\u2013548.","journal-title":"Nature Neuroscience"},{"issue":"4","key":"8282_CR3","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1006\/mcne.1999.0828","volume":"15","author":"F Amaya","year":"2000","unstructured":"Amaya, F., Decosterd, I., Samad, T. A., Plumpton, C., Tate, S., Mannion, R. J., et al. (2000). Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2. Molecular and Cellular Neuroscience, 15(4), 331\u2013342.","journal-title":"Molecular and Cellular Neuroscience"},{"issue":"Suppl 1","key":"8282_CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1468-1331.2005.01202.x","volume":"12","author":"P Andlin-Sobocki","year":"2005","unstructured":"Andlin-Sobocki, P., Jonsson, B., Wittchen, H. U., & Olesen, J. (2005). Cost of disorders of the brain in Europe. European Journal of Neurology, 12(Suppl 1), 1\u201327.","journal-title":"European Journal of Neurology"},{"issue":"11","key":"8282_CR5","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1177\/0333102412451360","volume":"32","author":"M Antonova","year":"2012","unstructured":"Antonova, M., Wienecke, T., Olesen, J., & Ashina, M. (2012). Prostaglandin E(2) induces immediate migraine-like attack in migraine patients without aura. Cephalalgia, 32(11), 822\u2013833.","journal-title":"Cephalalgia"},{"issue":"3","key":"8282_CR6","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.pain.2009.08.003","volume":"146","author":"A Arsenault","year":"2009","unstructured":"Arsenault, A., & Sawynok, J. (2009). Perisurgical amitriptyline produces a preventive effect on afferent hypersensitivity following spared nerve injury. Pain, 146(3), 308\u2013314.","journal-title":"Pain"},{"issue":"1","key":"8282_CR7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1526-4610.2005.05006.x","volume":"45","author":"HT Atasoy","year":"2005","unstructured":"Atasoy, H. T., Unal, A. E., Atasoy, N., Emre, U., & Sumer, M. (2005). Low income and education levels may cause medication overuse and chronicity in migraine patients. Headache, 45(1), 25\u201331.","journal-title":"Headache"},{"issue":"10","key":"8282_CR8","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1111\/j.1526-4637.2011.01200.x","volume":"12","author":"O Ates","year":"2011","unstructured":"Ates, O., Kurt, S., Altinisik, J., Karaer, H., & Sezer, S. (2011). Genetic variations in tumor necrosis factor alpha, interleukin-10 genes, and migraine susceptibility. Pain Medicine, 12(10), 1464\u20131469.","journal-title":"Pain Medicine"},{"issue":"3","key":"8282_CR9","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/01.RES.69.3.677","volume":"69","author":"MJ Barber","year":"1991","unstructured":"Barber, M. J., Starmer, C. F., & Grant, A. O. (1991). Blockade of cardiac sodium channels by amitriptyline and diphenylhydantoin. Evidence for two use-dependent binding sites. Circulation Research, 69(3), 677\u2013696.","journal-title":"Circulation Research"},{"issue":"5","key":"8282_CR10","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1023\/A:1015061317793","volume":"47","author":"K Bielefeldt","year":"2002","unstructured":"Bielefeldt, K., Ozaki, N., Whiteis, C., & Gebhart, G. F. (2002). Amitriptyline inhibits voltage-sensitive sodium currents in rat gastric sensory neurons. Digestive Diseases and Sciences, 47(5), 959\u2013966.","journal-title":"Digestive Diseases and Sciences"},{"issue":"23","key":"8282_CR11","doi-asserted-by":"crossref","first-page":"10277","DOI":"10.1523\/JNEUROSCI.22-23-10277.2002","volume":"22","author":"NT Blair","year":"2002","unstructured":"Blair, N. T., & Bean, B. P. (2002). Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons. The Journal of Neuroscience, 22(23), 10277\u201310290.","journal-title":"The Journal of Neuroscience"},{"issue":"2","key":"8282_CR12","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1006\/exnr.2000.7437","volume":"164","author":"U Bongenhielm","year":"2000","unstructured":"Bongenhielm, U., Nosrat, C. A., Nosrat, I., Eriksson, J., Fjell, J., & Fried, K. (2000). Expression of sodium channel SNS\/PN3 and ankyrin(G) mRNAs in the trigeminal ganglion after inferior alveolar nerve injury in the rat. Experimental Neurology, 164(2), 384\u2013395.","journal-title":"Experimental Neurology"},{"key":"8282_CR13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1744-8069-5-33","volume":"5","author":"CL Cang","year":"2009","unstructured":"Cang, C. L., Zhang, H., Zhang, Y. Q., & Zhao, Z. Q. (2009). PKCepsilon-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons. Molecular Pain, 5, 33.","journal-title":"Molecular Pain"},{"issue":"2","key":"8282_CR14","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.expneurol.2010.11.017","volume":"227","author":"X Chen","year":"2011","unstructured":"Chen, X., Pang, R. P., Shen, K. F., Zimmermann, M., Xin, W. J., Li, Y. Y., et al. (2011). TNF-alpha enhances the currents of voltage gated sodium channels in uninjured dorsal root ganglion neurons following motor nerve injury. Experimental Neurology, 227(2), 279\u2013286.","journal-title":"Experimental Neurology"},{"issue":"1","key":"8282_CR15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1471-2377-12-44","volume":"12","author":"KI Cheng","year":"2012","unstructured":"Cheng, K. I., Wang, H. C., Chang, L. L., Wang, F. Y., Lai, C. S., Chou, C. W., et al. (2012). Pretreatment with intrathecal amitriptyline potentiates anti-hyperalgesic effects of post-injury intra-peritoneal amitriptyline following spinal nerve ligation. BMC Neurology, 12(1), 44.","journal-title":"BMC Neurology"},{"issue":"Pt 11","key":"8282_CR16","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1113\/jphysiol.2010.187807","volume":"588","author":"R Cregg","year":"2010","unstructured":"Cregg, R., Momin, A., Rugiero, F., Wood, J. N., & Zhao, J. (2010). Pain channelopathies. The Journal of Physiology, 588(Pt 11), 1897\u20131904.","journal-title":"The Journal of Physiology"},{"issue":"Suppl 1","key":"8282_CR17","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1007\/s10072-010-0268-7","volume":"31","author":"D D\u2019Amico","year":"2010","unstructured":"D\u2019Amico, D. (2010). Pharmacological prophylaxis of chronic migraine: A review of double-blind placebo-controlled trials. Neurological Science, 31(Suppl 1), S23\u2013S28.","journal-title":"Neurological Science"},{"issue":"2","key":"8282_CR18","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/ng1081","volume":"33","author":"M Fusco De","year":"2003","unstructured":"De Fusco, M., Marconi, R., Silvestri, L., Atorino, L., Rampoldi, L., Morgante, L., et al. (2003). Haploinsufficiency of ATP1A2 encoding the Na+\/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nature Genetics, 33(2), 192\u2013196.","journal-title":"Nature Genetics"},{"issue":"9483","key":"8282_CR19","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0140-6736(05)66786-4","volume":"366","author":"M Dichgans","year":"2005","unstructured":"Dichgans, M., Freilinger, T., Eckstein, G., Babini, E., Lorenz-Depiereux, B., Biskup, S., et al. (2005). Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine. Lancet, 366(9483), 371\u2013377.","journal-title":"Lancet"},{"issue":"4","key":"8282_CR20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jpain.2006.10.001","volume":"8","author":"IE Dick","year":"2007","unstructured":"Dick, I. E., Brochu, R. M., Purohit, Y., Kaczorowski, G. J., Martin, W. J., & Priest, B. T. (2007). Sodium channel blockade may contribute to the analgesic efficacy of antidepressants. Journal of Pain, 8(4), 315\u2013324.","journal-title":"Journal of Pain"},{"issue":"Pt 2","key":"8282_CR21","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1113\/jphysiol.2002.026559","volume":"546","author":"L Djouhri","year":"2003","unstructured":"Djouhri, L., Newton, R., Levinson, S. R., Berry, C. M., Carruthers, B., & Lawson, S. N. (2003). Sensory and electrophysiological properties of guinea-pig sensory neurones expressing Nav 1.7 (PN1) Na+ channel alpha subunit protein. Journal of Physiology, 546(Pt 2), 565\u2013576.","journal-title":"Journal of Physiology"},{"key":"8282_CR22","unstructured":"Ducros, A. (2006). [Mechanisms and genetics of migraine]. CNS Drugs, 20 Spec no. 1, 1\u201311."},{"issue":"5","key":"8282_CR23","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.pain.2011.01.033","volume":"152","author":"A Ebersberger","year":"2011","unstructured":"Ebersberger, A., Natura, G., Eitner, A., Halbhuber, K. J., Rost, R., & Schaible, H. G. (2011). Effects of prostaglandin D2 on tetrodotoxin-resistant Na+ currents in DRG neurons of adult rat. Pain, 152(5), 1114\u20131126.","journal-title":"Pain"},{"key":"8282_CR24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1113\/jphysiol.1993.sp019583","volume":"463","author":"AA Elliott","year":"1993","unstructured":"Elliott, A. A., & Elliott, J. R. (1993). Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia. The Journal of Physiology, 463, 39\u201356.","journal-title":"The Journal of Physiology"},{"issue":"1\u20133","key":"8282_CR25","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.pain.2005.09.019","volume":"119","author":"J Eriksson","year":"2005","unstructured":"Eriksson, J., Jablonski, A., Persson, A. K., Hao, J. X., Kouya, P. F., Wiesenfeld-Hallin, Z., et al. (2005). Behavioral changes and trigeminal ganglion sodium channel regulation in an orofacial neuropathic pain model. Pain, 119(1\u20133), 82\u201394.","journal-title":"Pain"},{"issue":"7","key":"8282_CR26","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1007\/BF03017447","volume":"49","author":"JP Estebe","year":"2002","unstructured":"Estebe, J. P., Gentili, M. E., Le Corre, P., Le Verge, R., Moulinoux, J. P., & Ecoffey, C. (2002). Sciatic nerve block with bupivacaine-loaded microspheres prevents hyperalgesia in an inflammatory animal model. Canadian Journal of Anaesthesia, 49(7), 690\u2013693.","journal-title":"Canadian Journal of Anaesthesia"},{"issue":"7","key":"8282_CR27","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1074\/jbc.M605248200","volume":"282","author":"Z Fang","year":"2007","unstructured":"Fang, Z., Park, C. K., Li, H. Y., Kim, H. Y., Park, S. H., Jung, S. J., et al. (2007). Molecular basis of Ca(v)2.3 calcium channels in rat nociceptive neurons. Journal of Biological Chemistry, 282(7), 4757\u20134764.","journal-title":"Journal of Biological Chemistry"},{"issue":"3","key":"8282_CR28","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.pain.2005.08.013","volume":"118","author":"NB Finnerup","year":"2005","unstructured":"Finnerup, N. B., Otto, M., McQuay, H. J., Jensen, T. S., & Sindrup, S. H. (2005). Algorithm for neuropathic pain treatment: An evidence based proposal. Pain, 118(3), 289\u2013305.","journal-title":"Pain"},{"issue":"3","key":"8282_CR29","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.pain.2006.09.017","volume":"128","author":"E Fusayasu","year":"2007","unstructured":"Fusayasu, E., Kowa, H., Takeshima, T., Nakaso, K., & Nakashima, K. (2007). Increased plasma substance P and CGRP levels, and high ACE activity in migraineurs during headache-free periods. Pain, 128(3), 209\u2013214.","journal-title":"Pain"},{"issue":"4","key":"8282_CR30","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/00000542-200104000-00021","volume":"94","author":"P Gerner","year":"2001","unstructured":"Gerner, P., Mujtaba, M., Sinnott, C. J., & Wang, G. K. (2001). Amitriptyline versus bupivacaine in rat sciatic nerve blockade. Anesthesiology, 94(4), 661\u2013667.","journal-title":"Anesthesiology"},{"issue":"24","key":"8282_CR31","doi-asserted-by":"crossref","first-page":"10345","DOI":"10.1523\/JNEUROSCI.18-24-10345.1998","volume":"18","author":"MS Gold","year":"1998","unstructured":"Gold, M. S., Levine, J. D., & Correa, A. M. (1998). Modulation of TTX-R INa by PKC and PKA and their role in PGE2-induced sensitization of rat sensory neurons in vitro. The Journal of Neuroscience, 18(24), 10345\u201310355.","journal-title":"The Journal of Neuroscience"},{"issue":"4","key":"8282_CR32","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1085\/jgp.69.4.497","volume":"69","author":"B Hille","year":"1977","unstructured":"Hille, B. (1977). Local anesthetics: Hydrophilic and hydrophobic pathways for the drug-receptor reaction. The Journal of General Physiology, 69(4), 497\u2013515.","journal-title":"The Journal of General Physiology"},{"issue":"2","key":"8282_CR33","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s12272-001-1138-x","volume":"31","author":"YK Hur","year":"2008","unstructured":"Hur, Y. K., Choi, I. S., Cho, J. H., Park, E. J., Choi, J. K., Choi, B. J., et al. (2008). Effects of carbamazepine and amitriptyline on tetrodotoxinresistant Na+ channels in immature rat trigeminal ganglion neurons. Archives of Pharmacal Research, 31(2), 178\u2013182.","journal-title":"Archives of Pharmacal Research"},{"issue":"2\u20133","key":"8282_CR34","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0014-2999(92)90726-K","volume":"221","author":"Y Ishii","year":"1992","unstructured":"Ishii, Y., & Sumi, T. (1992). Amitriptyline inhibits striatal efflux of neurotransmitters via blockade of voltage-dependent Na+ channels. European Journal of Pharmacology, 221(2\u20133), 377\u2013380.","journal-title":"European Journal of Pharmacology"},{"issue":"2","key":"8282_CR35","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1601-0825.2010.01717.x","volume":"17","author":"MU Jang","year":"2011","unstructured":"Jang, M. U., Park, J. W., Kho, H. S., Chung, S. C., & Chung, J. W. (2011). Plasma and saliva levels of nerve growth factor and neuropeptides in chronic migraine patients. Oral Diseases, 17(2), 187\u2013193.","journal-title":"Oral Diseases"},{"issue":"20","key":"8282_CR36","doi-asserted-by":"crossref","first-page":"8520","DOI":"10.1073\/pnas.0611364104","volume":"104","author":"MF Jarvis","year":"2007","unstructured":"Jarvis, M. F., Honore, P., Shieh, C. C., Chapman, M., Joshi, S., Zhang, X. F., et al. (2007). A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proceedings of the National Academy of Sciences of the United States of America, 104(20), 8520\u20138525.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"8282_CR37","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jpain.2008.09.007","volume":"10","author":"SK Joshi","year":"2009","unstructured":"Joshi, S. K., Honore, P., Hernandez, G., Schmidt, R., Gomtsyan, A., Scanio, M., et al. (2009). Additive antinociceptive effects of the selective Nav1.8 blocker A-803467 and selective TRPV1 antagonists in rat inflammatory and neuropathic pain models. Journal of Pain, 10(3), 306\u2013315.","journal-title":"Journal of Pain"},{"issue":"1\u20132","key":"8282_CR38","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.pain.2006.02.011","volume":"123","author":"SK Joshi","year":"2006","unstructured":"Joshi, S. K., Mikusa, J. P., Hernandez, G., Baker, S., Shieh, C. C., Neelands, T., et al. (2006). Involvement of the TTX-resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post-operative, pain states. Pain, 123(1\u20132), 75\u201382.","journal-title":"Pain"},{"issue":"14","key":"8282_CR39","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1097\/00001756-200110080-00019","volume":"12","author":"BJ Kerr","year":"2001","unstructured":"Kerr, B. J., Souslova, V., McMahon, S. B., & Wood, J. N. (2001). A role for the TTX-resistant sodium channel Nav 1.8 in NGF-induced hyperalgesia, but not neuropathic pain. NeuroReport, 12(14), 3077\u20133080.","journal-title":"NeuroReport"},{"issue":"4 Suppl 1","key":"8282_CR40","first-page":"S61","volume":"39","author":"H Kwiecinski","year":"2005","unstructured":"Kwiecinski, H. (2005). Is migraine a neuronal channelopothy? Neurologia i Neurochirurgia Polska, 39(4 Suppl 1), S61\u2013S64.","journal-title":"Neurologia i Neurochirurgia Polska"},{"issue":"1\u20132","key":"8282_CR41","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0304-3959(01)00391-8","volume":"95","author":"J Lai","year":"2002","unstructured":"Lai, J., Gold, M. S., Kim, C. S., Bian, D., Ossipov, M. H., Hunter, J. C., et al. (2002). Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8. Pain, 95(1\u20132), 143\u2013152.","journal-title":"Pain"},{"issue":"19","key":"8282_CR42","doi-asserted-by":"crossref","first-page":"8352","DOI":"10.1523\/JNEUROSCI.22-19-08352.2002","volume":"22","author":"JM Laird","year":"2002","unstructured":"Laird, J. M., Souslova, V., Wood, J. N., & Cervero, F. (2002). Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS\/PN3)-null mice. The Journal of Neuroscience, 22(19), 8352\u20138356.","journal-title":"The Journal of Neuroscience"},{"issue":"1","key":"8282_CR43","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1124\/jpet.106.109025","volume":"320","author":"A Leffler","year":"2007","unstructured":"Leffler, A., Reiprich, A., Mohapatra, D. P., & Nau, C. (2007). Use-dependent block by lidocaine but not amitriptyline is more pronounced in tetrodotoxin (TTX)-Resistant Nav1.8 than in TTX-sensitive Na+ channels. Journal of Pharmacology and Experimental Therapeutics, 320(1), 354\u2013364.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"1","key":"8282_CR44","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1744-8069-9-31","volume":"9","author":"J Liang","year":"2013","unstructured":"Liang, J., Liu, X., Zheng, J., & Yu, S. (2013). Effect of amitriptyline on tetrodotoxin-resistant Nav1.9 currents in nociceptive trigeminal neurons. Molecular Pain, 9(1), 31.","journal-title":"Molecular Pain"},{"key":"8282_CR45","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainres.2011.09.048","volume":"1424","author":"J Liang","year":"2011","unstructured":"Liang, J., Yu, S., Dong, Z., Wang, X., Liu, R., Chen, X., et al. (2011). The effects of OB-induced depression on nociceptive behaviors induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus. Brain Research, 1424, 9\u201319.","journal-title":"Brain Research"},{"key":"8282_CR46","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1744-8069-2-5","volume":"2","author":"EA Matthews","year":"2006","unstructured":"Matthews, E. A., Wood, J. N., & Dickenson, A. H. (2006). Na(v) 1.8-null mice show stimulus-dependent deficits in spinal neuronal activity. Molecular Pain, 2, 5.","journal-title":"Molecular Pain"},{"issue":"3","key":"8282_CR47","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1124\/jpet.107.134148","volume":"324","author":"S McGaraughty","year":"2008","unstructured":"McGaraughty, S., Chu, K. L., Scanio, M. J., Kort, M. E., Faltynek, C. R., & Jarvis, M. F. (2008). A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats. Journal of Pharmacology and Experimental Therapeutics, 324(3), 1204\u20131211.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"3","key":"8282_CR48","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1213\/ane.0b013e3181b01b02","volume":"109","author":"E McGowan","year":"2009","unstructured":"McGowan, E., Hoyt, S. B., Li, X., Lyons, K. A., & Abbadie, C. (2009). A peripherally acting Na(v)1.7 sodium channel blocker reverses hyperalgesia and allodynia on rat models of inflammatory and neuropathic pain. Anesthesia and Analgesia, 109(3), 951\u2013958.","journal-title":"Anesthesia and Analgesia"},{"issue":"5","key":"8282_CR49","first-page":"579","volume":"51","author":"T Mert","year":"2012","unstructured":"Mert, T., & Gunes, Y. (2012). Antinociceptive activities of lidocaine and the nav1.8 blocker a803467 in diabetic rats. Journal of the American Association for Laboratory Animal Science, 51(5), 579\u2013585.","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"issue":"1","key":"8282_CR50","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1213\/ANE.0b013e318238002e","volume":"114","author":"JY Moon","year":"2012","unstructured":"Moon, J. Y., Song, S., Yoon, S. Y., Roh, D. H., Kang, S. Y., Park, J. H., et al. (2012). The differential effect of intrathecal Nav1.8 blockers on the induction and maintenance of capsaicin- and peripheral ischemia-induced mechanical allodynia and thermal hyperalgesia. Anesthesia and Analgesia, 114(1), 215\u2013223.","journal-title":"Anesthesia and Analgesia"},{"issue":"2","key":"8282_CR51","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/ana.410160202","volume":"16","author":"MA Moskowitz","year":"1984","unstructured":"Moskowitz, M. A. (1984). The neurobiology of vascular head pain. Annals of Neurology, 16(2), 157\u2013168.","journal-title":"Annals of Neurology"},{"issue":"2 (Pt 1)","key":"8282_CR52","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1212\/WNL.41.2_Part_1.182","volume":"41","author":"MA Moskowitz","year":"1991","unstructured":"Moskowitz, M. A. (1991). The visceral organ brain: Implications for the pathophysiology of vascular head pain. Neurology, 41(2 (Pt 1)), 182\u2013186.","journal-title":"Neurology"},{"issue":"3","key":"8282_CR53","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.pain.2005.04.002","volume":"116","author":"G Natura","year":"2005","unstructured":"Natura, G., von Banchet, G. S., & Schaible, H. G. (2005). Calcitonin gene-related peptide enhances TTX-resistant sodium currents in cultured dorsal root ganglion neurons from adult rats. Pain, 116(3), 194\u2013204.","journal-title":"Pain"},{"issue":"3","key":"8282_CR54","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0022-3565(24)35384-4","volume":"292","author":"C Nau","year":"2000","unstructured":"Nau, C., Seaver, M., Wang, S. Y., & Wang, G. K. (2000). Block of human heart hH1 sodium channels by amitriptyline. Journal of Pharmacology and Experimental Therapeutics, 292(3), 1015\u20131023.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"7","key":"8282_CR55","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S1474-4422(09)70090-0","volume":"8","author":"J Olesen","year":"2009","unstructured":"Olesen, J., Burstein, R., Ashina, M., & Tfelt-Hansen, P. (2009). Origin of pain in migraine: Evidence for peripheral sensitisation. The Lancet Neurology, 8(7), 679\u2013690.","journal-title":"The Lancet Neurology"},{"issue":"3","key":"8282_CR56","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0092-8674(00)81373-2","volume":"87","author":"RA Ophoff","year":"1996","unstructured":"Ophoff, R. A., Terwindt, G. M., Vergouwe, M. N., van Eijk, R., Oefner, P. J., Hoffman, S. M., et al. (1996). Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell, 87(3), 543\u2013552.","journal-title":"Cell"},{"issue":"1","key":"8282_CR57","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0022-3565(24)37206-4","volume":"284","author":"JJ Pancrazio","year":"1998","unstructured":"Pancrazio, J. J., Kamatchi, G. L., Roscoe, A. K., & Lynch, C, 3rd. (1998). Inhibition of neuronal Na+ channels by antidepressant drugs. Journal of Pharmacology and Experimental Therapeutics, 284(1), 208\u2013214.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"5","key":"8282_CR58","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1073\/pnas.252777799","volume":"100","author":"CA Parada","year":"2003","unstructured":"Parada, C. A., Vivancos, G. G., Tambeli, C. H., Cunha, F. Q., & Ferreira, S. H. (2003). Activation of presynaptic NMDA receptors coupled to NaV1.8-resistant sodium channel C-fibers causes retrograde mechanical nociceptor sensitization. Proceedings of the National Academy of Sciences of the United States of America, 100(5), 2923\u20132928.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"10","key":"8282_CR59","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1177\/0022034510377094","volume":"89","author":"CK Park","year":"2010","unstructured":"Park, C. K., Bae, J. H., Kim, H. Y., Jo, H. J., Kim, Y. H., Jung, S. J., et al. (2010). Substance P sensitizes P2X3 in nociceptive trigeminal neurons. Journal of Dental Research, 89(10), 1154\u20131159.","journal-title":"Journal of Dental Research"},{"issue":"14","key":"8282_CR60","doi-asserted-by":"crossref","first-page":"7640","DOI":"10.1073\/pnas.96.14.7640","volume":"96","author":"F Porreca","year":"1999","unstructured":"Porreca, F., Lai, J., Bian, D., Wegert, S., Ossipov, M. H., Eglen, R. M., et al. (1999). A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3\/SNS and NaN\/SNS2, in rat models of chronic pain. Proceedings of the National Academy of Sciences of the United States of America, 96(14), 7640\u20137644.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"8282_CR61","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1152\/jn.2001.86.2.629","volume":"86","author":"M Renganathan","year":"2001","unstructured":"Renganathan, M., Cummins, T. R., & Waxman, S. G. (2001). Contribution of Na(v)1.8 sodium channels to action potential electrogenesis in DRG neurons. Journal of Neurophysiology, 86(2), 629\u2013640.","journal-title":"Journal of Neurophysiology"},{"issue":"7","key":"8282_CR62","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nm1074","volume":"10","author":"MA Rogawski","year":"2004","unstructured":"Rogawski, M. A., & Loscher, W. (2004). The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions. Nature Medicine, 10(7), 685\u2013692.","journal-title":"Nature Medicine"},{"issue":"1","key":"8282_CR63","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1460-9568.2005.04186.x","volume":"22","author":"AM Rush","year":"2005","unstructured":"Rush, A. M., Craner, M. J., Kageyama, T., Dib-Hajj, S. D., Waxman, S. G., & Ranscht, B. (2005). Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons. European Journal of Neuroscience, 22(1), 39\u201349.","journal-title":"European Journal of Neuroscience"},{"issue":"1","key":"8282_CR64","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/0333102410365108","volume":"31","author":"TJ Schwedt","year":"2011","unstructured":"Schwedt, T. J., Krauss, M. J., Frey, K., & Gereau, R. W. (2011). Episodic and chronic migraineurs are hypersensitive to thermal stimuli between migraine attacks. Cephalalgia, 31(1), 6\u201312.","journal-title":"Cephalalgia"},{"issue":"19","key":"8282_CR65","doi-asserted-by":"crossref","first-page":"7279","DOI":"10.1523\/JNEUROSCI.20-19-07279.2000","volume":"20","author":"AA Sleeper","year":"2000","unstructured":"Sleeper, A. A., Cummins, T. R., Dib-Hajj, S. D., Hormuzdiar, W., Tyrrell, L., Waxman, S. G., et al. (2000). Changes in expression of two tetrodotoxin-resistant sodium channels and their currents in dorsal root ganglion neurons after sciatic nerve injury but not rhizotomy. Journal of Neuroscience, 20(19), 7279\u20137289.","journal-title":"Journal of Neuroscience"},{"issue":"5","key":"8282_CR66","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1755-5949.2010.00170.x","volume":"17","author":"TA Smitherman","year":"2010","unstructured":"Smitherman, T. A., Walters, A. B., Maizels, M., & Penzien, D. B. (2010). The use of antidepressants for headache prophylaxis. CNS Neuroscience & Therapeutics, 17(5), 462\u2013469.","journal-title":"CNS Neuroscience & Therapeutics"},{"issue":"3","key":"8282_CR67","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0014-2999(00)00460-X","volume":"401","author":"JH Song","year":"2000","unstructured":"Song, J. H., Ham, S. S., Shin, Y. K., & Lee, C. S. (2000). Amitriptyline modulation of Na(+) channels in rat dorsal root ganglion neurons. European Journal of Pharmacology, 401(3), 297\u2013305.","journal-title":"European Journal of Pharmacology"},{"issue":"1","key":"8282_CR68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1129-2377-14-1","volume":"14","author":"TJ Steiner","year":"2013","unstructured":"Steiner, T. J., Stovner, L. J., & Birbeck, G. L. (2013). Migraine: The seventh disabler. Journal of Headache Pain, 14(1), 1.","journal-title":"Journal of Headache Pain"},{"issue":"1\u20132","key":"8282_CR69","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0304-3959(02)00375-5","volume":"103","author":"Y Sudoh","year":"2003","unstructured":"Sudoh, Y., Cahoon, E. E., Gerner, P., & Wang, G. K. (2003). Tricyclic antidepressants as long-acting local anesthetics. Pain, 103(1\u20132), 49\u201355.","journal-title":"Pain"},{"issue":"2","key":"8282_CR70","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neulet.2003.12.048","volume":"357","author":"B Sung","year":"2004","unstructured":"Sung, B., & Wang, G. K. (2004). Peripherally administered amitriptyline derivatives have differential anti-allodynic effects in a rat model of neuropathic pain. Neuroscience Letters, 357(2), 115\u2013118.","journal-title":"Neuroscience Letters"},{"issue":"1","key":"8282_CR71","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/ALN.0b013e318278cade","volume":"118","author":"MR Suter","year":"2013","unstructured":"Suter, M. R., Kirschmann, G., Laedermann, C. J., Abriel, H., & Decosterd, I. (2013). Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. Anesthesiology, 118(1), 160\u2013172.","journal-title":"Anesthesiology"},{"issue":"1","key":"8282_CR72","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/157488907779561754","volume":"2","author":"I Tarnawa","year":"2007","unstructured":"Tarnawa, I., Bolcskei, H., & Kocsis, P. (2007). Blockers of voltage-gated sodium channels for the treatment of central nervous system diseases. Recent Patents on CNS Drug Discovery, 2(1), 57\u201378.","journal-title":"Recent Patents on CNS Drug Discovery"},{"issue":"5","key":"8282_CR73","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/00127893-200109000-00002","volume":"7","author":"SJ Tepper","year":"2001","unstructured":"Tepper, S. J., Rapoport, A., & Sheftell, F. (2001). The pathophysiology of migraine. Neurologist, 7(5), 279\u2013286.","journal-title":"Neurologist"},{"issue":"1","key":"8282_CR74","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3109\/00365517609068012","volume":"36","author":"C Thorstrand","year":"1976","unstructured":"Thorstrand, C., Bergstrom, J., & Castenfors, J. (1976). Cardiac effects of amitriptyline in rats. Scandinavian Journal of Clinical and Laboratory Investigation, 36(1), 7\u201315.","journal-title":"Scandinavian Journal of Clinical and Laboratory Investigation"},{"issue":"1\u20132","key":"8282_CR75","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/s0304-3959(02)00183-5","volume":"102","author":"O Veneroni","year":"2003","unstructured":"Veneroni, O., Maj, R., Calabresi, M., Faravelli, L., Fariello, R. G., & Salvati, P. (2003). Anti-allodynic effect of NW-1029, a novel Na(+) channel blocker, in experimental animal models of inflammatory and neuropathic pain. Pain, 102(1\u20132), 17\u201325.","journal-title":"Pain"},{"issue":"2","key":"8282_CR76","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neulet.2005.04.060","volume":"386","author":"CF Villarreal","year":"2005","unstructured":"Villarreal, C. F., Sachs, D., Cunha, F. Q., Parada, C. A., & Ferreira, S. H. (2005). The role of Na(V)1.8 sodium channel in the maintenance of chronic inflammatory hypernociception. Neuroscience Letters, 386(2), 72\u201377.","journal-title":"Neuroscience Letters"},{"issue":"1\u20132","key":"8282_CR77","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.pain.2004.03.018","volume":"110","author":"GK Wang","year":"2004","unstructured":"Wang, G. K., Russell, C., & Wang, S. Y. (2004). State-dependent block of voltage-gated Na+ channels by amitriptyline via the local anesthetic receptor and its implication for neuropathic pain. Pain, 110(1\u20132), 166\u2013174.","journal-title":"Pain"},{"key":"8282_CR78","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1741-7015-9-116","volume":"9","author":"GA Weir","year":"2011","unstructured":"Weir, G. A., & Cader, M. Z. (2011). New directions in migraine. BMC Medicine, 9, 116.","journal-title":"BMC Medicine"},{"issue":"2","key":"8282_CR79","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.neulet.2011.11.031","volume":"506","author":"W Wu","year":"2012","unstructured":"Wu, W., Ye, Q., Wang, W., Yan, L., Wang, Q., Xiao, H., et al. (2012). Amitriptyline modulates calcium currents and intracellular calcium concentration in mouse trigeminal ganglion neurons. Neuroscience Letters, 506(2), 307\u2013311.","journal-title":"Neuroscience Letters"},{"key":"8282_CR80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2010.04.016","volume":"1336","author":"L Yan","year":"2010","unstructured":"Yan, L., Wang, Q., Fu, Q., Ye, Q., Xiao, H., & Wan, Q. (2010). Amitriptyline inhibits currents and decreases the mRNA expression of voltage-gated sodium channels in cultured rat cortical neurons. Brain Research, 1336, 1\u20139.","journal-title":"Brain Research"},{"key":"8282_CR81","doi-asserted-by":"crossref","unstructured":"Yu, S., He, M., Liu, R., Feng, J., Qiao, X., Yang, X., et al. (2013). Headache yesterday in China: A new approach to estimating the burden of headache, applied in a general-population survey in China. Cephalalgia, 33(15), 1211\u20131217.","DOI":"10.1177\/0333102413490347"},{"issue":"4","key":"8282_CR82","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/j.1526-4610.2011.02061.x","volume":"52","author":"S Yu","year":"2012","unstructured":"Yu, S., Liu, R., Zhao, G., Yang, X., Qiao, X., Feng, J., et al. (2012). The prevalence and burden of primary headaches in China: A population-based door-to-door survey. Headache, 52(4), 582\u2013591.","journal-title":"Headache"},{"issue":"5","key":"8282_CR83","doi-asserted-by":"crossref","first-page":"e19865","DOI":"10.1371\/journal.pone.0019865","volume":"6","author":"Y Yu","year":"2011","unstructured":"Yu, Y., Zhao, F., Guan, S., & Chen, J. (2011). Antisense-mediated knockdown of Na(V)1.8, but not Na(V)1.9, generates inhibitory effects on complete Freund\u2019s adjuvant-induced inflammatory pain in rat. PLoS One, 6(5), e19865.","journal-title":"PLoS One"},{"issue":"3","key":"8282_CR84","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1124\/jpet.107.132456","volume":"324","author":"I Zahradnik","year":"2008","unstructured":"Zahradnik, I., Minarovic, I., & Zahradnikova, A. (2008). Inhibition of the cardiac L-type calcium channel current by antidepressant drugs. Journal of Pharmacology and Experimental Therapeutics, 324(3), 977\u2013984.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"7146","key":"8282_CR85","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/nature05880","volume":"447","author":"K Zimmermann","year":"2007","unstructured":"Zimmermann, K., Leffler, A., Babes, A., Cendan, C. M., Carr, R. W., Kobayashi, J., et al. (2007). Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures. Nature, 447(7146), 855\u2013858.","journal-title":"Nature"}],"container-title":["NeuroMolecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-013-8282-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12017-013-8282-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-013-8282-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:28:27Z","timestamp":1746059307000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12017-013-8282-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,30]]},"references-count":85,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["8282"],"URL":"https:\/\/doi.org\/10.1007\/s12017-013-8282-6","relation":{},"ISSN":["1535-1084","1559-1174"],"issn-type":[{"type":"print","value":"1535-1084"},{"type":"electronic","value":"1559-1174"}],"subject":[],"published":{"date-parts":[[2013,11,30]]}}}