{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:33:40Z","timestamp":1790040820773,"version":"4.0.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuromol Med"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s12017-018-8502-1","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T14:18:48Z","timestamp":1531750728000},"page":"409-417","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["RNA Sequencing and Pathway Analysis Identify Important Pathways Involved in Hypertrichosis and Intellectual Disability in Patients with Wiedemann\u2013Steiner Syndrome"],"prefix":"10.1007","volume":"20","author":[{"given":"L\u00e9o","family":"Mietton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Lebrun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Giurgea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Goldenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Saintpierre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Hamroune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Afenjar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Billuart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5953-2728","authenticated-orcid":false,"given":"Thierry","family":"Bienvenu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,16]]},"reference":[{"key":"8502_CR1","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.ejmg.2017.03.006","volume":"60","author":"A Aggarwal","year":"2017","unstructured":"Aggarwal, A., Rodriguez, D. F., & Northrup, H. (2017). Wiedemann-Steiner syndrome: Novel pathogenic variant and review of literature. European Journal of Medical Genetics, 60, 285\u2013288.","journal-title":"European Journal of Medical Genetics"},{"issue":"Database issue","key":"8502_CR2","first-page":"D530","volume":"41","author":"JA Blake","year":"2013","unstructured":"Blake, J. A., et al. (2013). Gene Ontology annotations and resources. Nucleic Acids Research, 41(Database issue), D530\u2013D535.","journal-title":"Nucleic Acids Research"},{"issue":"10","key":"8502_CR3","doi-asserted-by":"publisher","first-page":"2861","DOI":"10.1093\/hmg\/ddv046","volume":"24","author":"E Brookes","year":"2015","unstructured":"Brookes, E., et al. (2015). Mutations in the intellectual disability gene KDM5C reduce protein stability and demethylase activity. Human Molecular Genetics, 24(10), 2861\u20132872.","journal-title":"Human Molecular Genetics"},{"issue":"9","key":"8502_CR4","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1523\/JNEUROSCI.5071-04.2005","volume":"25","author":"J Chen","year":"2005","unstructured":"Chen, J., et al. (2005). Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in mice. Journal of Neurosciences, 25(9), 2366\u20132375.","journal-title":"Journal of Neurosciences"},{"issue":"2","key":"8502_CR5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nrg3607","volume":"15","author":"T Chen","year":"2014","unstructured":"Chen, T., & Dent, S. Y. (2014). Chromatin modifiers and remodellers: regulators of cellular differentiation. Nature Review Genetics, 15(2), 93\u2013106.","journal-title":"Nature Review Genetics"},{"issue":"8","key":"8502_CR6","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1111\/j.1742-4658.2010.07609.x","volume":"277","author":"MS Cosgrove","year":"2010","unstructured":"Cosgrove, M. S., & Patel, A. (2010). Mixed lineage leukemia: a structure-function perspective of the MLL1 protein. FEBS Journal, 277(8), 1832\u20131842.","journal-title":"FEBS Journal"},{"issue":"9","key":"8502_CR7","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1093\/bioinformatics\/bth078","volume":"20","author":"MJ Hoon de","year":"2004","unstructured":"de Hoon, M. J., Imoto, S., Nolan, J., & Miyano, S. (2004). Open source clustering software. Bioinformatics, 20(9), 1453\u20131454.","journal-title":"Bioinformatics"},{"issue":"9","key":"8502_CR8","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.4161\/epi.6.9.16069","volume":"6","author":"PA Rizzo Del","year":"2011","unstructured":"Del Rizzo, P. A., & Trievel, R. C. (2011). Substrate and product specificities of SET domain methyltransferases. Epigenetics, 6(9), 1059\u20131067.","journal-title":"Epigenetics"},{"issue":"4","key":"8502_CR9","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1182\/blood-2006-08-039651","volume":"109","author":"F Diehl","year":"2007","unstructured":"Diehl, F., et al. (2007). The histone methyltransferase MLL is an upstream regulator of endothelial-cell sprout formation. Blood, 109(4), 1472\u20131478.","journal-title":"Blood"},{"issue":"1","key":"8502_CR10","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin, A., et al. (2013). STAR: ultrafast universal RNA-seq aligner. Bioinformatics, 29(1), 15\u201321.","journal-title":"Bioinformatics"},{"key":"8502_CR11","doi-asserted-by":"publisher","first-page":"e2217","DOI":"10.1038\/cddis.2016.120","volume":"7","author":"J Gao","year":"2016","unstructured":"Gao, J., et al. (2016). Transcription factor Six2 mediates the protection of GDNF on 6-OHDA lesioned dopaminergic neurons by regulating Smurf1 expression. Cell Death Disease, 7, e2217.","journal-title":"Cell Death Disease"},{"issue":"24","key":"8502_CR12","doi-asserted-by":"publisher","first-page":"8603","DOI":"10.1073\/pnas.0503072102","volume":"102","author":"MG Guenther","year":"2005","unstructured":"Guenther, M. G., et al. (2005). Global and Hox-specific roles for the MLL1 methyltransferase. Proceedings of the National Academy of Sciences USA, 102(24), 8603\u20138608.","journal-title":"Proceedings of the National Academy of Sciences USA"},{"issue":"24","key":"8502_CR13","doi-asserted-by":"publisher","first-page":"6297","DOI":"10.1113\/jphysiol.2012.240762","volume":"590","author":"Y Hellsten","year":"2012","unstructured":"Hellsten, Y., et al. (2012). Vasodilator interactions in skeletal muscle blood flow regulation. Journal of Physiology, 590(24), 6297\u20136305.","journal-title":"Journal of Physiology"},{"key":"8502_CR14","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.fitote.2016.08.008","volume":"114","author":"A Herman","year":"2016","unstructured":"Herman, A., & Herman, A. P. (2016). Mechanism of action of herbs and their active constituents used in hair loss treatment. Fitoterapia, 114, 18\u201325.","journal-title":"Fitoterapia"},{"issue":"2","key":"8502_CR15","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.ajhg.2012.06.008","volume":"91","author":"WD Jones","year":"2012","unstructured":"Jones, W. D., et al. (2012). De novo mutations in MLL cause Wiedemann-Steiner syndrome. American Journal of Human Genetics, 91(2), 358\u2013364.","journal-title":"American Journal of Human Genetics"},{"issue":"12","key":"8502_CR16","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1038\/nsmb.1961","volume":"17","author":"S Katada","year":"2010","unstructured":"Katada, S., & Sassone-Corsi, P. (2010). The histone methyltransferase MLL1 permits the oscillation of circadian gene expression. Nature Structural & Molecular Biology, 17(12), 1414\u20131421.","journal-title":"Nature Structural & Molecular Biology"},{"issue":"3","key":"8502_CR17","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.celrep.2017.06.072","volume":"20","author":"C Kerimoglu","year":"2017","unstructured":"Kerimoglu, C., et al. (2017). KMT2A and KMT2B mediate memory function by affecting distinct genomic regions. Cell Reports, 20(3), 538\u2013548.","journal-title":"Cell Reports"},{"issue":"4","key":"8502_CR18","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","volume":"128","author":"T Kouzarides","year":"2007","unstructured":"Kouzarides, T. (2007). Chromatin modifications and their function. Cell, 128(4), 693\u2013705.","journal-title":"Cell"},{"issue":"1","key":"8502_CR19","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41431-017-0033-y","volume":"26","author":"N Lebrun","year":"2017","unstructured":"Lebrun, N., et al. (2017). Molecular and cellular issues of KMT2A variants involved in Wiedemann-Steiner syndrome. European Journal of Human Genetics, 26(1), 107\u2013116.","journal-title":"European Journal of Human Genetics"},{"issue":"6","key":"8502_CR21","doi-asserted-by":"publisher","first-page":"H2761","DOI":"10.1152\/ajpheart.01344.2007","volume":"294","author":"Z Li","year":"2008","unstructured":"Li, Z., et al. (2008). Inhibitory effect of D1-like and D3 dopamine receptors on norepinephrine-induced proliferation in vascular smooth muscle cells. American Journal of Physiology Heart and Circulation Physiology, 294(6), H2761\u2013H2768.","journal-title":"American Journal of Physiology Heart and Circulation Physiology"},{"issue":"7","key":"8502_CR22","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","volume":"30","author":"Y Liao","year":"2014","unstructured":"Liao, Y., Smyth, G. K., & Shi, W. (2014). FeatureCounts: an efficient general-purpose program for assigning sequence reads to genomic features. Bioinformatics, 30(7), 923\u2013930.","journal-title":"Bioinformatics"},{"key":"8502_CR23","first-page":"730139","volume":"2015","author":"WH Lin","year":"2015","unstructured":"Lin, W. H., et al. (2015). Fibroblast growth factors stimulate hair growth through \u03b2-catenin and Shh expression in C57BL\/6 mice. BioMed Research International, 2015, 730139.","journal-title":"BioMed Research International"},{"key":"8502_CR24","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M. I., Huber, W., & Anders, S. (2014). Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biology, 15, 550.","journal-title":"Genome Biology"},{"issue":"8","key":"8502_CR25","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1111\/j.1742-4658.2010.07607.x","volume":"277","author":"S Malik","year":"2010","unstructured":"Malik, S., & Bhaumik, S. R. (2010). Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human. FEBS Journal, 277(8), 1805\u20131821.","journal-title":"FEBS Journal"},{"issue":"7","key":"8502_CR26","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1387\/ijdb.052110cm","volume":"50","author":"CS Merzdorf","year":"2006","unstructured":"Merzdorf, C. S., & Sive, H. L. (2006). The zic1 gene is an activator of Wnt signaling. The International Journal of Developmental Biology, 50(7), 611\u2013617.","journal-title":"The International Journal of Developmental Biology"},{"issue":"3","key":"8502_CR27","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1073\/pnas.0408836102","volume":"102","author":"TA Milne","year":"2005","unstructured":"Milne, T. A., et al. (2005). Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proceedings of the National Academy of Sciences USA, 102(3),749\u2013754.","journal-title":"Proceedings of the National Academy of Sciences USA"},{"issue":"1","key":"8502_CR28","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/cge.12586","volume":"89","author":"N Miyake","year":"2016","unstructured":"Miyake, N., et al. (2016). Delineation of clinical features in Wiedemann-Steiner syndrome caused by KMT2A mutations. Clinical Genetics, 89(1), 115\u2013119.","journal-title":"Clinical Genetics"},{"key":"8502_CR29","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0079-6123(08)63205-7","volume":"118","author":"RR Mize","year":"1998","unstructured":"Mize, R. R., et al. (1998). The role of nitric oxide in development of the patch-cluster system and retinocollicular pathways in the rodent superior colliculus. Progress in Brain Research, 118, 133\u2013152.","journal-title":"Progress in Brain Research"},{"issue":"3","key":"8502_CR30","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/S0006-291X(03)00183-9","volume":"302","author":"H Ohuchi","year":"2003","unstructured":"Ohuchi, H., et al. (2003). Fibroblast growth factor 10 is required for proper development of the mouse whiskers. Biochemical and Biophysical Research Communications, 302(3), 562\u2013567.","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"2","key":"8502_CR31","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.devcel.2013.09.025","volume":"27","author":"T Oyama","year":"2013","unstructured":"Oyama, T., et al. (2013). Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs. Developmental Cell, 27(2), 188\u2013200.","journal-title":"Developmental Cell"},{"issue":"10","key":"8502_CR32","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1101\/lm.029363.112","volume":"20","author":"S Parkel","year":"2013","unstructured":"Parkel, S., Lopez-Atalaya, J. P., & Barco, A. (2013). Histone H3 lysine methylation in cognition and intellectual disability disorders. Learning & Memory, 20(10), 570\u2013579.","journal-title":"Learning & Memory"},{"issue":"3","key":"8502_CR33","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1055\/s-0035-1564442","volume":"4","author":"L Pezzani","year":"2015","unstructured":"Pezzani, L., Milani, D., & Tadini, G. (2015). Intellectual disability: When the hypertrichosis is a clue. Journal of Pediatrics Genetics, 4(3), 154\u2013158.","journal-title":"Journal of Pediatrics Genetics"},{"issue":"4","key":"8502_CR34","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1002\/path.2440","volume":"216","author":"F Pont\u00e9n","year":"2008","unstructured":"Pont\u00e9n, F., Jirstr\u00f6m, K., & Uhlen, M. (2008). The Human protein atlas\u2014a tool for pathology. Journal of Pathology, 216(4), 387\u2013393.","journal-title":"Journal of Pathology"},{"issue":"26","key":"8502_CR35","doi-asserted-by":"publisher","first-page":"5122","DOI":"10.1016\/j.febslet.2007.09.061","volume":"581","author":"R Pourebrahim","year":"2007","unstructured":"Pourebrahim, R., et al. (2007). ZIC1 gene expression is controlled by DNA and histone methylation in mesenchymal proliferations. FEBS Letters, 581(26), 5122\u20135126.","journal-title":"FEBS Letters"},{"issue":"1\u20132","key":"8502_CR36","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0925-4773(98)00177-4","volume":"78","author":"BC Powell","year":"1998","unstructured":"Powell, B. C., et al. (1998). The Notch signalling pathway in hair growth. Mechanisms of Development, 78(1\u20132), 189\u2013192.","journal-title":"Mechanisms of Development"},{"issue":"1","key":"8502_CR37","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.3390\/ijms15011647","volume":"15","author":"P Rishikaysh","year":"2014","unstructured":"Rishikaysh, P., et al. (2014). Signaling involved in hair follicle morphogenesis and development. International Journal of Molecular Sciences, 15(1), 1647\u20131670.","journal-title":"International Journal of Molecular Sciences"},{"issue":"5","key":"8502_CR38","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nrg3413","volume":"14","author":"JL Ronan","year":"2013","unstructured":"Ronan, J. L., Wu, W., & Crabtree, G. R. (2013). From neural development to cognition: unexpected roles for chromatin. Nature Reviews Genetics, 14(5), 347\u2013359.","journal-title":"Nature Reviews Genetics"},{"issue":"Database issue","key":"8502_CR39","doi-asserted-by":"publisher","first-page":"D620","DOI":"10.1093\/nar\/gkp961","volume":"38","author":"KR Rosenbloom","year":"2010","unstructured":"Rosenbloom, K. R., et al. (2010). ENCODE whole-genome data in the UCSC Genome Browser. Nucleic Acids Research, 38(Database issue), D620\u2013D625.","journal-title":"Nucleic Acids Research"},{"issue":"17","key":"8502_CR40","doi-asserted-by":"publisher","first-page":"3246","DOI":"10.1093\/bioinformatics\/bth349","volume":"20","author":"AJ Saldanha","year":"2004","unstructured":"Saldanha, A. J. (2004). Java TreeView\u2013extensible visualization of microarray data. Bioinformatics, 20(17), 3246\u20133248.","journal-title":"Bioinformatics"},{"issue":"43","key":"8502_CR41","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A., et al (2005). Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences of the United States of America, 102(43), 15545\u201315550.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"8502_CR42","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1002\/ajmg.a.38025","volume":"173","author":"Y Sun","year":"2017","unstructured":"Sun, Y., et al. (2017). Further delineation of the phenotype of truncating KMT2A mutations: The extended Wiedemann-Steiner syndrome. American Journal of Medical Genetics A, 173(2), 510\u2013514.","journal-title":"American Journal of Medical Genetics A"},{"issue":"3","key":"8502_CR43","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.ajhg.2015.07.007","volume":"97","author":"SR Twigg","year":"2015","unstructured":"Twigg, S. R., et al. (2015). Gain-of-Function Mutations in ZIC1 Are Associated with Coronal Craniosynostosis and Learning Disability. American Journal of Human Genetics, 97(3), 378\u2013388.","journal-title":"American Journal of Human Genetics"},{"issue":"3","key":"8502_CR44","doi-asserted-by":"publisher","first-page":"503","DOI":"10.2217\/epi.15.1","volume":"7","author":"CN Vallianatos","year":"2015","unstructured":"Vallianatos, C. N., & Iwase, S. (2015). Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders. Epigenomics, 7(3), 503\u2013519.","journal-title":"Epigenomics"},{"issue":"10","key":"8502_CR45","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1038\/ncb2827","volume":"15","author":"D Wang","year":"2013","unstructured":"Wang, D., et al. (2013). MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway. Nature Cell Biology, 15(10), 1153\u20131163.","journal-title":"Nature Cell Biology"},{"key":"8502_CR46","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1186\/1752-0509-5-S2-S3","volume":"5","author":"X Wang","year":"2011","unstructured":"Wang, X., & Zhang, X. (2011). Pinpointing transcription factor binding sites from ChIP-seq data with SeqSite. BMC Systems Biology, 5, S3.","journal-title":"BMC Systems Biology"},{"key":"8502_CR47","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s13072-016-0103-3","volume":"9","author":"M Wiersma","year":"2016","unstructured":"Wiersma, M., et al. (2016). Protein kinase Msk1 physically and functionally interacts with the KMT2A\/MLL1methyltransferase complex and contributes to the regulation of multiple target genes. Epigenetics & Chromatin, 9, 52.","journal-title":"Epigenetics & Chromatin"},{"issue":"2","key":"8502_CR48","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1002\/bip.22126","volume":"99","author":"P Zhang","year":"2013","unstructured":"Zhang, P., Bergamin, E., & Couture, J. F. (2013). The many facets of MLL1 regulation. Biopolymers, 99(2), 136\u2013145.","journal-title":"Biopolymers"}],"container-title":["NeuroMolecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12017-018-8502-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-018-8502-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-018-8502-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T19:49:19Z","timestamp":1693770559000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12017-018-8502-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,16]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["8502"],"URL":"https:\/\/doi.org\/10.1007\/s12017-018-8502-1","relation":{},"ISSN":["1535-1084","1559-1174"],"issn-type":[{"value":"1535-1084","type":"print"},{"value":"1559-1174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,16]]},"assertion":[{"value":"18 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors have declared no conflicting interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}