{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T22:20:29Z","timestamp":1776982829283,"version":"3.51.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuromol Med"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s12017-019-08529-7","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T09:09:25Z","timestamp":1553677765000},"page":"160-169","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Neuronal Ceroid Lipofuscinoses-Linked Loss of Function CLN5 and CLN8 Variants Disrupt Normal Lysosomal Function"],"prefix":"10.1007","volume":"21","author":[{"given":"Shaho","family":"Parvin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Rezazadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Hosseinzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Moradi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadi","family":"Shiva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2613-3421","authenticated-orcid":false,"given":"Jalal","family":"Gharesouran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,3,27]]},"reference":[{"issue":"1","key":"8529_CR1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/mgg3.263","volume":"5","author":"C Beesley","year":"2017","unstructured":"Beesley, C., Guerreiro, R. J., Bras, J. T., Williams, R. E., Taratuto, A. L., Eltze, C., & Mole, S. E. (2017). CLN 8 disease caused by large genomic deletions. Molecular Genetics & Genomic Medicine, 5(1), 85\u201391.","journal-title":"Molecular Genetics & Genomic Medicine"},{"issue":"2","key":"8529_CR2","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s10048-005-0024-y","volume":"7","author":"N Cannelli","year":"2006","unstructured":"Cannelli, N., Cassandrini, D., Bertini, E., Striano, P., Fusco, L., Gaggero, R.,.. . Bruno, C. (2006). Novel mutations in CLN8 in Italian variant late infantile neuronal ceroid lipofuscinosis: Another genetic hit in the Mediterranean. Neurogenetics, 7(2), 111.","journal-title":"Neurogenetics"},{"issue":"1","key":"8529_CR3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12881-018-0535-7","volume":"19","author":"Z Gao","year":"2018","unstructured":"Gao, Z., Xie, H., Jiang, Q., Wu, N., Chen, X., & Chen, Q. (2018). Identification of two novel null variants in CLN8 by targeted next-generation sequencing: First report of a Chinese patient with neuronal ceroid lipofuscinosis due to CLN8 variants. BMC medical genetics, 19(1), 21.","journal-title":"BMC medical genetics"},{"issue":"3","key":"8529_CR4","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00018-010-0468-6","volume":"68","author":"AL Getty","year":"2011","unstructured":"Getty, A. L., & Pearce, D. A. (2011). Interactions of the proteins of neuronal ceroid lipofuscinosis: Clues to function. Cellular and molecular life sciences, 68(3), 453\u2013474.","journal-title":"Cellular and molecular life sciences"},{"issue":"24","key":"8529_CR5","doi-asserted-by":"publisher","first-page":"3798","DOI":"10.1002\/elps.201200472","volume":"33","author":"SE Haddad","year":"2012","unstructured":"Haddad, S. E., Khoury, M., Daoud, M., Kantar, R., Harati, H., Mousallem, T.,.. . Boustany, R. M. (2012). CLN 5 and CLN 8 protein association with ceramide synthase: B iochemical and proteomic approaches. Electrophoresis, 33(24), 3798\u20133809.","journal-title":"Electrophoresis"},{"key":"8529_CR6","volume-title":"Batten disease: Diagnosis, treatment, and research","author":"JC Hall","year":"2001","unstructured":"Hall, J. C., Dunlap, J. C., Friedmann, T., Giannelli, F., Wisniewski, K. E., & Zhong, N. (2001). Batten disease: Diagnosis, treatment, and research (Vol. 45). Amsterdam: Elsevier."},{"issue":"1","key":"8529_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jnen\/62.1.1","volume":"62","author":"M Haltia","year":"2003","unstructured":"Haltia, M. (2003). The neuronal ceroid-lipofuscinoses. Journal of Neuropathology & Experimental Neurology, 62(1), 1\u201313.","journal-title":"Journal of Neuropathology & Experimental Neurology"},{"issue":"2","key":"8529_CR8","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/j.1750-3639.2000.tb00255.x","volume":"10","author":"R Herva","year":"2000","unstructured":"Herva, R., Tyynel\u00e4, J., Hirvasniemi, A., Syrj\u00e4kallio-Ylitalo, M., & Haltia, M. (2000). Northern epilepsy: A novel form of neuronal ceroid-lipofuscinosis. Brain Pathology, 10(2), 215\u2013222.","journal-title":"Brain Pathology"},{"issue":"1","key":"8529_CR9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.nbd.2003.12.019","volume":"16","author":"V Holmberg","year":"2004","unstructured":"Holmberg, V., Jalanko, A., Isosomppi, J., Fabritius, A.-L., Peltonen, L., & Kopra, O. (2004). The mouse ortholog of the neuronal ceroid lipofuscinosis CLN5 gene encodes a soluble lysosomal glycoprotein expressed in the developing brain. Neurobiology of Disease, 16(1), 29\u201340.","journal-title":"Neurobiology of Disease"},{"issue":"4","key":"8529_CR10","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.bbamcr.2008.11.004","volume":"1793","author":"A Jalanko","year":"2009","unstructured":"Jalanko, A., & Braulke, T. (2009). Neuronal ceroid lipofuscinoses. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1793(4), 697\u2013709.","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Cell Research"},{"issue":"3","key":"8529_CR11","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.braindev.2015.09.008","volume":"38","author":"Y Katata","year":"2016","unstructured":"Katata, Y., Uematsu, M., Sato, H., Suzuki, S., Nakayama, T., Kubota, Y.,.. . Kure, S. (2016). Novel missense mutation in CLN8 in late infantile neuronal ceroid lipofuscinosis: The first report of a CLN8 mutation in Japan. Brain and Development, 38(3), 341\u2013345.","journal-title":"Brain and Development"},{"issue":"11","key":"8529_CR12","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1016\/j.bbadis.2013.01.019","volume":"1832","author":"K Kollmann","year":"2013","unstructured":"Kollmann, K., Uusi-Rauva, K., Scifo, E., Tyynel\u00e4, J., Jalanko, A., & Braulke, T. (2013). Cell biology and function of neuronal ceroid lipofuscinosis-related proteins. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1832(11), 1866\u20131881.","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease"},{"issue":"23","key":"8529_CR13","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1093\/hmg\/ddh312","volume":"13","author":"O Kopra","year":"2004","unstructured":"Kopra, O., Vesa, J., von Schantz, C., Manninen, T., Minye, H., Fabritius, A.-L.,.. . Jalanko, A. (2004). A mouse model for Finnish variant late infantile neuronal ceroid lipofuscinosis, CLN5, reveals neuropathology associated with early aging. Human Molecular Genetics, 13(23), 2893\u20132906.","journal-title":"Human Molecular Genetics"},{"issue":"1","key":"8529_CR14","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/humu.21624","volume":"33","author":"M Kousi","year":"2012","unstructured":"Kousi, M., Lehesjoki, A. E., & Mole, S. E. (2012). Update of the mutation spectrum and clinical correlations of over 360 mutations in eight genes that underlie the neuronal ceroid lipofuscinoses. Human Mutation, 33(1), 42\u201363.","journal-title":"Human Mutation"},{"issue":"11","key":"8529_CR15","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1093\/hmg\/9.11.1691","volume":"9","author":"L Lonka","year":"2000","unstructured":"Lonka, L., Kytt\u00e4l\u00e4, A., Ranta, S., Jalanko, A., & Lehesjoki, A.-E. (2000). The neuronal ceroid lipofuscinosis CLN8 membrane protein is a resident of the endoplasmic reticulum. Human Molecular Genetics, 9(11), 1691\u20131697.","journal-title":"Human Molecular Genetics"},{"issue":"6","key":"8529_CR16","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1002\/jnr.20133","volume":"76","author":"L Lonka","year":"2004","unstructured":"Lonka, L., Salonen, T., Siintola, E., Kopra, O., Lehesjoki, A. E., & Jalanko, A. (2004). Localization of wild-type and mutant neuronal ceroid lipofuscinosis CLN8 proteins in non-neuronal and neuronal cells. Journal of Neuroscience Research, 76(6), 862\u2013871.","journal-title":"Journal of Neuroscience Research"},{"issue":"4","key":"8529_CR17","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.pediatrneurol.2012.05.016","volume":"47","author":"M Mahajnah","year":"2012","unstructured":"Mahajnah, M., & Zelnik, N. (2012). Phenotypic heterogeneity in consanguineous patients with a common CLN8 mutation. Pediatric Neurology, 47(4), 303\u2013305.","journal-title":"Pediatric Neurology"},{"issue":"10","key":"8529_CR18","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1128\/MCB.06726-11","volume":"32","author":"A Mamo","year":"2012","unstructured":"Mamo, A., Jules, F., Dumaresq-Doiron, K., Costantino, S., & Lefrancois, S. (2012). The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting. Molecular and Cellular Biology, 32(10), 1855\u20131866.","journal-title":"Molecular and Cellular Biology"},{"issue":"1","key":"8529_CR19","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s00415-014-7553-y","volume":"262","author":"C Mancini","year":"2015","unstructured":"Mancini, C., Nassani, S., Guo, Y., Chen, Y., Giorgio, E., Brussino, A.,.. . Funaro, A. (2015). Adult-onset autosomal recessive ataxia associated with neuronal ceroid lipofuscinosis type 5 gene (CLN5) mutations. Journal of Neurology, 262(1), 173\u2013178.","journal-title":"Journal of Neurology"},{"issue":"6","key":"8529_CR20","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1016\/j.bbadis.2017.04.003","volume":"1863","author":"D Marotta","year":"2017","unstructured":"Marotta, D., Tinelli, E., & Mole, S. E. (2017). NCLs and ER: A stressful relationship. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1863(6), 1273\u20131281.","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease"},{"issue":"6918","key":"8529_CR21","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/nature01250","volume":"421","author":"LO Martinez","year":"2003","unstructured":"Martinez, L. O., Jacquet, S., Esteve, J.-P., Rolland, C., Cabez\u00f3n, E., Champagne, E.,.. . Terc\u00e9, F. (2003). Ectopic \u03b2-chain of ATP synthase is an apolipoprotein AI receptor in hepatic HDL endocytosis. Nature, 421(6918), 75.","journal-title":"Nature"},{"issue":"10","key":"8529_CR22","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1016\/j.bbadis.2015.05.011","volume":"1852","author":"SE Mole","year":"2015","unstructured":"Mole, S. E., & Cotman, S. L. (2015). Genetics of the neuronal ceroid lipofuscinoses (Batten disease). Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1852(10), 2237\u20132241.","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease"},{"issue":"3","key":"8529_CR23","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s10048-005-0218-3","volume":"6","author":"SE Mole","year":"2005","unstructured":"Mole, S. E., Williams, R. E., & Goebel, H. H. (2005). Correlations between genotype, ultrastructural morphology and clinical phenotype in the neuronal ceroid lipofuscinoses. Neurogenetics, 6(3), 107\u2013126.","journal-title":"Neurogenetics"},{"issue":"4","key":"8529_CR24","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1002\/humu.20018","volume":"23","author":"S Ranta","year":"2004","unstructured":"Ranta, S., Topcu, M., Tegelberg, S., Tan, H., \u00dcst\u00fcb\u00fct\u00fcn, A., Saatci, I.,.. . Alembik, Y. (2004). Variant late infantile neuronal ceroid lipofuscinosis in a subset of Turkish patients is allelic to Northern epilepsy. Human Mutation, 23(4), 300\u2013305.","journal-title":"Human Mutation"},{"issue":"1","key":"8529_CR25","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1399-0004.2009.01285.x","volume":"77","author":"K Reinhardt","year":"2010","unstructured":"Reinhardt, K., Grapp, M., Schlachter, K., Br\u00fcck, W., G\u00e4rtner, J., & Steinfeld, R. (2010). Novel CLN8 mutations confirm the clinical and ethnic diversity of late infantile neuronal ceroid lipofuscinosis. Clinical Genetics, 77(1), 79\u201385.","journal-title":"Clinical Genetics"},{"issue":"3","key":"8529_CR26","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1002\/humu.21195","volume":"31","author":"ML Schmiedt","year":"2010","unstructured":"Schmiedt, M. L., Bessa, C., Heine, C., Ribeiro, M. G., Jalanko, A., & Kytt\u00e4l\u00e4, A. (2010). The neuronal ceroid lipofuscinosis protein CLN5: New insights into cellular maturation, transport, and consequences of mutations. Human Mutation, 31(3), 356\u2013365.","journal-title":"Human Mutation"},{"issue":"1","key":"8529_CR27","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.nbd.2011.12.009","volume":"46","author":"M-L Schmiedt","year":"2012","unstructured":"Schmiedt, M.-L., Blom, T., Blom, T., Kopra, O., Wong, A., von Schantz-Fant, C.,.. . Cooper, J. D. (2012). Cln5-deficiency in mice leads to microglial activation, defective myelination and changes in lipid metabolism. Neurobiology of Disease, 46(1), 19\u201329.","journal-title":"Neurobiology of Disease"},{"issue":"3","key":"8529_CR28","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1002\/ana.20187","volume":"56","author":"A Schulz","year":"2004","unstructured":"Schulz, A., Dhar, S., Rylova, S., Dbaibo, G., Alroy, J., Hagel, C.,.. . Boustany, R. M. (2004). Impaired cell adhesion and apoptosis in a novel CLN9 Batten disease variant. Annals of Neurology, 56(3), 342\u2013350.","journal-title":"Annals of Neurology"},{"issue":"2","key":"8529_CR29","doi-asserted-by":"publisher","first-page":"117","DOI":"10.4103\/1817-1745.117840","volume":"8","author":"G Setty","year":"2013","unstructured":"Setty, G., Saleem, R., Khan, A., & Hussain, N. (2013). Atypical juvenile neuronal ceroid lipofuscinosis: A report of three cases. Journal of Pediatric Neurosciences, 8(2), 117.","journal-title":"Journal of Pediatric Neurosciences"},{"issue":"1","key":"8529_CR30","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1086\/518902","volume":"81","author":"E Siintola","year":"2007","unstructured":"Siintola, E., Topcu, M., Aula, N., Lohi, H., Minassian, B. A., Paterson, A. D.,.. . Anttonen, A.-K. (2007). The novel neuronal ceroid lipofuscinosis gene MFSD8 encodes a putative lysosomal transporter. The American Journal of Human Genetics, 81(1), 136\u2013146.","journal-title":"The American Journal of Human Genetics"},{"issue":"4","key":"8529_CR31","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/j.1750-3639.2004.tb00077.x","volume":"14","author":"J Tyynel\u00e4","year":"2004","unstructured":"Tyynel\u00e4, J., Cooper, J. D., Khan, M. N., Shemilt, S. J., & Haltia, M. (2004). Hippocampal pathology in the human neuronal ceroid-lipofuscinoses: Distinct patterns of storage deposition, neurodegeneration and glial activation. Brain Pathology, 14(4), 349\u2013357.","journal-title":"Brain Pathology"},{"issue":"5","key":"8529_CR32","doi-asserted-by":"publisher","first-page":"955","DOI":"10.3390\/ijms18050955","volume":"18","author":"K Uusi-Rauva","year":"2017","unstructured":"Uusi-Rauva, K., Blom, T., von Schantz-Fant, C., Blom, T., Jalanko, A., & Kytt\u00e4l\u00e4, A. (2017). Induced pluripotent stem cells derived from a CLN5 patient manifest phenotypic characteristics of neuronal ceroid lipofuscinoses. International Journal of Molecular Sciences, 18(5), 955.","journal-title":"International Journal of Molecular Sciences"},{"issue":"7","key":"8529_CR33","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1002\/humu.21012","volume":"30","author":"C Vantaggiato","year":"2009","unstructured":"Vantaggiato, C., Redaelli, F., Falcone, S., Perrotta, C., Tonelli, A., Bondioni, S.,.. . Bonaglia, M. C. (2009). A novel CLN8 mutation in late-infantile-onset neuronal ceroid lipofuscinosis (LINCL) reveals aspects of CLN8 neurobiological function. Human Mutation, 30(7), 1104\u20131116.","journal-title":"Human Mutation"},{"issue":"5","key":"8529_CR34","doi-asserted-by":"publisher","first-page":"439","DOI":"10.2174\/1566524023362311","volume":"2","author":"J Vesa","year":"2002","unstructured":"Vesa, J., & Peltonen, L. (2002). Mutated genes in juvenile and variant late infantile neuronal ceroid lipofuscinoses encode lysosomal proteins. Current Molecular Medicine, 2(5), 439\u2013444.","journal-title":"Current Molecular Medicine"},{"issue":"1","key":"8529_CR35","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/1471-2164-9-146","volume":"9","author":"C Schantz von","year":"2008","unstructured":"von Schantz, C., Saharinen, J., Kopra, O., Cooper, J. D., Gentile, M., Hovatta, I.,.. . Jalanko, A. (2008). Brain gene expression profiles of Cln1 and Cln5 deficient mice unravels common molecular pathways underlying neuronal degeneration in NCL diseases. BMC Genomics, 9(1), 146.","journal-title":"BMC Genomics"},{"issue":"11","key":"8529_CR36","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1016\/j.bbadis.2013.03.017","volume":"1832","author":"V Warrier","year":"2013","unstructured":"Warrier, V., Vieira, M., & Mole, S. E. (2013). Genetic basis and phenotypic correlations of the neuronal ceroid lipofusinoses. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1832(11), 1827\u20131830.","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease"},{"issue":"2","key":"8529_CR37","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1212\/WNL.0b013e31825f0547","volume":"79","author":"RE Williams","year":"2012","unstructured":"Williams, R. E., & Mole, S. E. (2012). New nomenclature and classification scheme for the neuronal ceroid lipofuscinoses. Neurology, 79(2), 183\u2013191.","journal-title":"Neurology"},{"issue":"8","key":"8529_CR38","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/S0968-0004(02)02154-0","volume":"27","author":"E Winter","year":"2002","unstructured":"Winter, E., & Ponting, C. P. (2002). TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains? Trends in Biochemical Sciences, 27(8), 381\u2013383.","journal-title":"Trends in Biochemical Sciences"},{"issue":"7","key":"8529_CR39","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1212\/WNL.0b013e3181cff70d","volume":"74","author":"W Xin","year":"2010","unstructured":"Xin, W., Mullen, T., Kiely, R., Min, J., Feng, X., Cao, Y.,.. . Mole, S. (2010). CLN5 mutations are frequent in juvenile and late-onset non-Finnish patients with NCL. Neurology, 74(7), 565\u2013571.","journal-title":"Neurology"},{"issue":"6","key":"8529_CR40","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.pediatrneurol.2007.01.008","volume":"36","author":"N Zelnik","year":"2007","unstructured":"Zelnik, N., Mahajna, M., Iancu, T. C., Sharony, R., & Zeigler, M. (2007). A novel mutation of the CLN8 gene: is there a Mediterranean phenotype? Pediatric Neurology, 36(6), 411\u2013413.","journal-title":"Pediatric Neurology"}],"container-title":["NeuroMolecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-019-08529-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12017-019-08529-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-019-08529-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T00:10:41Z","timestamp":1585181441000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12017-019-08529-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,27]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["8529"],"URL":"https:\/\/doi.org\/10.1007\/s12017-019-08529-7","relation":{},"ISSN":["1535-1084","1559-1174"],"issn-type":[{"value":"1535-1084","type":"print"},{"value":"1559-1174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,27]]},"assertion":[{"value":"20 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}