{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:37:48Z","timestamp":1790437068998,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Medical Univeristy of Silesia","award":["KNW-2-003N\/3\/N"],"award-info":[{"award-number":["KNW-2-003N\/3\/N"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuromol Med"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to find the potential association between<jats:italic>HSPA1B<\/jats:italic>polymorphisms and risk of paranoid schizophrenia, clinical variables of the disease, and suicidal behavior. A total of 901 unrelated Polish subjects of Caucasian origin (377 schizophrenia patients and 524 controls) were recruited. Four single-nucleotide polymorphisms (SNP) were genotyped using PCR\u2013RFLP (rs539689, rs9281590) and TaqMan assays (rs263979, rs6547452). A strong tendency towards statistical significance (<jats:italic>p<\/jats:italic>\u2009=\u20090.051) was observed in rs539689 allele distribution between patients and controls in overall study subjects. After stratification according to gender, we found that rs539689 was significantly associated with schizophrenia in males, but not in females. The minor allele C had a protective effect in males [OR\u20090.73 (95% CI 0.61\u20130.88,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05)]. In addition, two SNPs (rs539689, rs9281590) were significantly associated with PANSS scores. Another important finding was a strong significant association between the<jats:italic>HSPA1B<\/jats:italic>rs539689 polymorphism and attempted suicide in schizophrenic patients. The C\/C genotype and C allele were protective against suicidal behavior in entire sample (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), in males (<jats:italic>p\u2009<\/jats:italic>&lt;\u2009001), and in females (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), although associations were weaker than in males. Our findings support that<jats:italic>HSPA1B<\/jats:italic>gene may be involved in susceptibility to schizophrenia and clinical presentation of the disease in a sex-dependent manner, and may play a role in suicidal behavior in the Polish population of schizophrenic patients. Further independent analyses in different populations should be performed to clarify the role of<jats:italic>HSPA1B<\/jats:italic>in the pathogenesis of schizophrenia.<\/jats:p>","DOI":"10.1007\/s12017-019-08575-1","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T16:15:35Z","timestamp":1571847335000},"page":"159-169","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Association of HSPA1B Polymorphisms with Paranoid Schizophrenia in a Polish Population"],"prefix":"10.1007","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6679-1368","authenticated-orcid":false,"given":"Malgorzata","family":"Kowalczyk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Kucia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksander","family":"Owczarek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Suchanek-Raif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Merk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Fila-Danilow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Paul-Samojedny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Choreza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kowalski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,23]]},"reference":[{"key":"8575_CR1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0952-3278(96)90153-2","volume":"55","author":"PR Bates","year":"1996","unstructured":"Bates, P. R., Hawkins, A., Mahadik, S. P., & McGrath, J. J. (1996). Heat stress lipids and schizophrenia. Prostaglandins Leukotrienes and Essential Fatty Acids,55, 101\u2013107.","journal-title":"Prostaglandins Leukotrienes and Essential Fatty Acids"},{"issue":"2","key":"8575_CR2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1046\/j.1471-4159.2000.740641.x","volume":"74","author":"DA Bechtold","year":"2000","unstructured":"Bechtold, D. A., Rush, S. J., & Brown, I. R. (2000). Localization of the heat-shock protein Hsp70 to the synapse following hyperthermic stress in the brain. Journal of Neurochemistry,74(2), 641\u2013646.","journal-title":"Journal of Neurochemistry"},{"key":"8575_CR3","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1212\/WNL.0b013e31820c3119","volume":"76","author":"EE Benarroch","year":"2011","unstructured":"Benarroch, E. E. (2011). Heat shock proteins: Multiple neuroprotective functions and implications for neurologic disease. Neurology,76, 660\u2013667.","journal-title":"Neurology"},{"key":"8575_CR4","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/mp.2012.73","volume":"17","author":"SE Bergen","year":"2012","unstructured":"Bergen, S. E., O\u2019Dushlaine, C. T., & Ripke, S. (2012). Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. Molecular Psychiatry,17, 880\u2013886.","journal-title":"Molecular Psychiatry"},{"issue":"3","key":"8575_CR5","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.neubiorev.2010.10.008","volume":"35","author":"BY Bitanihirwe","year":"2011","unstructured":"Bitanihirwe, B. Y., & Woo, T.-U. W. (2011). Oxidative stress in schizophrenia: An integrated approach. Neuroscience and Biobehavioral Reviews,35(3), 878\u2013893.","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"8575_CR6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1196\/annals.1391.032","volume":"1113","author":"IR Brown","year":"2007","unstructured":"Brown, I. R. (2007). Heat shock proteins and protection of the nervous system. Annals of the New York Academy of Sciences,1113, 147\u2013158.","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"11","key":"8575_CR7","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1089\/ars.2009.3074","volume":"13","author":"V Calabrese","year":"2010","unstructured":"Calabrese, V., Cornelius, C., Dinkova-Kostova, A. T., Calabrese, E. J., & Mattson, M. P. (2010). Cellular stress responses, the hormesis paradigm, and vitagenes: Novel targets for therapeutic intervention in neurodegenerative disorders. Antioxidants & Redox Signaling,13(11), 176\u20131811.","journal-title":"Antioxidants & Redox Signaling"},{"issue":"5","key":"8575_CR8","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1002\/jnr.23967","volume":"95","author":"V Calabrese","year":"2017","unstructured":"Calabrese, V., Giordano, J., Crupi, R., Di Paola, R., Ruggieri, M., Bianchini, R., et al. (2017). Hormesis, cellular stress response and neuroinflammation in schizophrenia: Early onset versus late onset state. Journal of Neuroscience Research,95(5), 1182\u20131193.","journal-title":"Journal of Neuroscience Research"},{"key":"8575_CR9","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1177\/0891988703256051","volume":"16","author":"J Clarimon","year":"2003","unstructured":"Clarimon, J., Bertranpetit, J., Boada, M., T\u00e0rraga, L., & Comas, D. (2003). HSP70-2 (HSPA1B) is associated with noncognitive symptoms in late-onset Alzheimer\u2019s disease. Journal of Geriatric Psychiatry and Neurology,16, 146\u2013150.","journal-title":"Journal of Geriatric Psychiatry and Neurology"},{"issue":"1\u20132","key":"8575_CR10","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1159\/000135642","volume":"57","author":"PM Czerski","year":"2008","unstructured":"Czerski, P. M., Rybakowski, F., Kapelski, P., Rybakowski, J. K., Dmitrzak-Weglarz, M., Leszczy\u0144ska-Rodziewicz, A., et al. (2008). Association of tumor necrosis factor -308G\/A promoter polymorphism with schizophrenia and bipolar affective disorder in a Polish population. Neuropsychobiology,57(1\u20132), 88\u201394.","journal-title":"Neuropsychobiology"},{"issue":"10","key":"8575_CR11","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/ng1885","volume":"38","author":"PI de Bakker","year":"2006","unstructured":"de Bakker, P. I., McVean, G., Sabeti, P. C., Miretti, M. M., Green, T., Marchini, J., et al. (2006). A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nature Genetics,38(10), 1166\u20131172.","journal-title":"Nature Genetics"},{"key":"8575_CR12","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1093\/schbul\/sbn187","volume":"35","author":"SH Fatemi","year":"2009","unstructured":"Fatemi, S. H., & Folsom, T. D. (2009). The neurodevelopmental hypothesis of schizophrenia, revisited. Schizophrenia Bulletin,35, 528\u2013548.","journal-title":"Schizophrenia Bulletin"},{"key":"8575_CR13","volume-title":"Structured clinical interview for DSM-IV axis I disorders, clinician version (SCID-CV)","author":"MB First","year":"1997","unstructured":"First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. (1997). Structured clinical interview for DSM-IV axis I disorders, clinician version (SCID-CV). Washington: American Psychiatric Press."},{"issue":"6","key":"8575_CR14","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.biopsych.2013.03.018","volume":"74","author":"J Flatow","year":"2013","unstructured":"Flatow, J., Buckley, P., & Miller, B. J. (2013). Meta-analysis of oxidative stress in schizophrenia. Biological Psychiatry,74(6), 400\u2013409.","journal-title":"Biological Psychiatry"},{"key":"8575_CR15","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.psyneuen.2015.10.008","volume":"63","author":"L Ganan\u00e7a","year":"2016","unstructured":"Ganan\u00e7a, L., Oquendo, M. A., Tyrka, A. R., Cisneros-Trujillo, S., Mann, J. J., & Sublette, M. E. (2016). The role of cytokines in the pathophysiology of suicidal behavior. Psychoneuroendocrinology,63, 296\u2013310.","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"8575_CR16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.psc.2009.12.003","volume":"33","author":"PV Gejman","year":"2010","unstructured":"Gejman, P. V., Sanders, A. R., & Duan, J. (2010). The role of genetics in the etiology of schizophrenia. Psychiatric Clinics of North America,33(1), 35\u201366.","journal-title":"Psychiatric Clinics of North America"},{"key":"8575_CR17","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1176\/ps.2006.57.6.844","volume":"57","author":"LS Grossman","year":"2006","unstructured":"Grossman, L. S., Harrow, M., Rosen, C., & Faull, R. (2006). Sex differences in outcome and recovery for schizophrenia and other psychotic and nonpsychotic disorders. Psychiatric Services (Washington, D. C.),57, 844\u2013850.","journal-title":"Psychiatric Services (Washington, D. C.)"},{"issue":"24","key":"8575_CR18","doi-asserted-by":"crossref","first-page":"7576","DOI":"10.1158\/0008-5472.CAN-11-1409","volume":"71","author":"H Guo","year":"2011","unstructured":"Guo, H., Deng, Q., Wu, C., Hu, L., Wei, S., Xu, P., et al. (2011). Variations in HSPA1B at 6p21.3 are associated with lung cancer risk and prognosis in Chinese populations. Cancer Research,71(24), 7576\u20137586.","journal-title":"Cancer Research"},{"issue":"3","key":"8575_CR19","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1379\/CSC-265.1","volume":"12","author":"S Guo","year":"2007","unstructured":"Guo, S., Wharton, W., Moseley, P., & Shi, H. (2007). Heat shock protein 70 regulates cellular redox status by modulating glutathione-related enzyme activities. Cell Stress and Chaperones,12(3), 245\u2013254.","journal-title":"Cell Stress and Chaperones"},{"key":"8575_CR20","doi-asserted-by":"crossref","first-page":"540273","DOI":"10.1155\/2012\/540273","volume":"2012","author":"E Hayes","year":"2012","unstructured":"Hayes, E., Gavrilidis, E., & Kulkarni, J. (2012). The role of oestrogen and other hormones in the pathophysiology and treatment of schizophrenia. Schizophrenia Research and Treatment,2012, 540273.","journal-title":"Schizophrenia Research and Treatment"},{"issue":"5","key":"8575_CR21","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.exger.2009.10.006","volume":"45","author":"Y Hou","year":"2010","unstructured":"Hou, Y., Wei, H., Luo, Y., & Liu, G. (2010). Modulating expression of brain heat shock proteins by estrogen in ovariectomized mice model of aging. Experimental Gerontology,45(5), 323\u2013330.","journal-title":"Experimental Gerontology"},{"key":"8575_CR22","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/schbul\/sbp006","volume":"35","author":"OD Howes","year":"2009","unstructured":"Howes, O. D., & Kapur, S. (2009). The dopamine hypothesis of schizophrenia: Version III-the final common pathway. Schizophrenia Bulletin,35, 549\u2013562.","journal-title":"Schizophrenia Bulletin"},{"issue":"2","key":"8575_CR23","first-page":"4","volume":"2","author":"D Huang","year":"2017","unstructured":"Huang, D., & Liu, S. (2017). Oxidative stress and schizophrenia. JPBS,2(2), 4.","journal-title":"JPBS"},{"key":"8575_CR24","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1136\/jmedgenet-2011-100397","volume":"49","author":"P Jia","year":"2012","unstructured":"Jia, P., Wang, L., Fanous, A. H., Chen, X., Kendler, K. S., International Schizophrenia Consortium, et al. (2012). A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia. Journal of Medical Genetics,49, 96\u2013103.","journal-title":"Journal of Medical Genetics"},{"key":"8575_CR25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0165-1781(88)90038-8","volume":"23","author":"SR Kay","year":"1988","unstructured":"Kay, S. R., Opler, L. A., & Lindenmayer, J. P. (1988). Reliability and validity of the positive and negative syndrome scale for schizophrenics. Psychiatry Research,23, 99\u2013110.","journal-title":"Psychiatry Research"},{"issue":"8","key":"8575_CR26","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1186\/1471-2164-8-413","volume":"12","author":"S Kim","year":"2007","unstructured":"Kim, S., Choi, K. H., Baykiz, A. F., & Gershenfeld, H. K. (2007). Suicide candidate genes associated with bipolar disorder and schizophrenia: An exploratory gene expression profiling analysis of post-mortem prefrontal cortex. BMC Genomics,12(8), 413.","journal-title":"BMC Genomics"},{"key":"8575_CR27","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0920-9964(00)00091-8","volume":"52","author":"JJ Kim","year":"2001","unstructured":"Kim, J. J., Lee, S. J., Toh, K. Y., Lee, C. U., Lee, C., & Paik, I. H. (2001). Identification of antibodies to heat shock proteins 90\u00a0kDa and 70\u00a0kDa in patients with schizophrenia. Schizophrenia Research,52, 127\u2013135.","journal-title":"Schizophrenia Research"},{"key":"8575_CR28","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00406-007-0791-6","volume":"258","author":"JJ Kim","year":"2008","unstructured":"Kim, J. J., Mandelli, L., Lim, S., Lim, H. K., Kwon, O. J., Pae, C. U., et al. (2008). Association analysis of heat shock protein 70 gene polymorphisms in schizophrenia. European Archives of Psychiatry and Clinical Neuroscience,258, 239\u2013244.","journal-title":"European Archives of Psychiatry and Clinical Neuroscience"},{"key":"8575_CR29","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s12192-013-0446-7","volume":"19","author":"M Kowalczyk","year":"2014","unstructured":"Kowalczyk, M., Owczarek, A., Suchanek, R., Paul-Samojedny, M., Fila-Danilow, A., Borkowska, P., et al. (2014). Heat shock protein 70 gene polymorphisms are associated with paranoid schizophrenia in the Polish population. Cell Stress and Chaperones,19, 205\u2013215.","journal-title":"Cell Stress and Chaperones"},{"key":"8575_CR30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1601-183X.2011.00734.x","volume":"11","author":"W Li","year":"2012","unstructured":"Li, W., Wang, X., Zhao, J., Lin, J., Song, X. Q., Yang, Y., et al. (2012). Association study of myelin transcription factor 1-like polymorphisms with schizophrenia in Han Chinese population. Genes, Brain and Behavior,11, 87\u201393.","journal-title":"Genes, Brain and Behavior"},{"key":"8575_CR31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1365-2796.2009.02132.x","volume":"267","author":"A Marucci","year":"2010","unstructured":"Marucci, A., Miscio, G., Padovano, L., Boonyasrisawat, W., Doria, A., Trischitta, V., et al. (2010). A functional variant in the gene 3\u2032 untranslated region regulates HSP70 expression and is a potential candidate for insulin resistance-related abnormalities. Journal of Internal Medicine,267, 237\u2013240.","journal-title":"Journal of Internal Medicine"},{"key":"8575_CR32","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/BF00187095","volume":"32","author":"CM Milner","year":"1990","unstructured":"Milner, C. M., & Campbell, R. D. (1990). Structure and expression of the three MHC-linked HSP70 genes. Immunogenetics,32, 242\u2013251.","journal-title":"Immunogenetics"},{"issue":"6","key":"8575_CR33","doi-asserted-by":"crossref","first-page":"479","DOI":"10.4172\/2155-9899.1000479","volume":"7","author":"R Mokhtari","year":"2016","unstructured":"Mokhtari, R., & Lachman, H. M. (2016). The major histocompatibility complex (MHC) in schizophrenia: A review. Journal of Clinical and Cellular Immunology,7(6), 479.","journal-title":"Journal of Clinical and Cellular Immunology"},{"issue":"3","key":"8575_CR34","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2174\/157339510791823673","volume":"6","author":"N M\u00fcller","year":"2010","unstructured":"M\u00fcller, N., & Schwarz, M. J. (2010). Immune system and schizophrenia. Current Immunology Reviews,6(3), 213\u2013220.","journal-title":"Current Immunology Reviews"},{"issue":"4","key":"8575_CR35","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1080\/13811110903266418","volume":"13","author":"MD Omrani","year":"2009","unstructured":"Omrani, M. D., Bushehri, B., Bagheri, M., Salari-Lak, S., Alipour, A., Anoshae, M. R., et al. (2009). Role of IL-10 -1082, IFN-gamma +874, and TNF-alpha -308 genes polymorphisms in suicidal behavior. Archives of Suicide Research,13(4), 330\u2013339.","journal-title":"Archives of Suicide Research"},{"key":"8575_CR36","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000218075","volume":"59","author":"CU Pae","year":"2009","unstructured":"Pae, C. U., Drago, A., Kim, J. J., Mandelli, L., De Ronchi, D., & Serretti, A. (2009). The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients. Neuropsychobiology,59, 135\u2013141.","journal-title":"Neuropsychobiology"},{"key":"8575_CR37","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.neures.2005.05.004","volume":"53","author":"CU Pae","year":"2005","unstructured":"Pae, C. U., Kim, T. S., Kwon, O. J., Artioli, P., Serretti, A., Lee, C. U., et al. (2005). Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia. Neuroscience Research,53, 8\u201313.","journal-title":"Neuroscience Research"},{"key":"8575_CR38","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s12031-010-9442-x","volume":"43","author":"M Paul-Samojedny","year":"2011","unstructured":"Paul-Samojedny, M., Owczarek, A., Suchanek, R., Kowalczyk, M., Fila-Danilow, A., Borkowska, P., et al. (2011). Association study of interferon gamma (IFN-gamma) +874T\/A gene polymorphism in patients with paranoid schizophrenia. Journal of Molecular Neuroscience,43, 309\u2013315.","journal-title":"Journal of Molecular Neuroscience"},{"key":"8575_CR39","first-page":"25","volume-title":"Heat shock proteins in neural cells","author":"K Reed-Herbert","year":"2006","unstructured":"Reed-Herbert, K., Samali, A., & Gorman, A. M. (2006). The role of heat shock proteins in neuronal differentiation and development. In C. Richter-Landsberg (Ed.), Heat shock proteins in neural cells (pp. 25\u201337). New York: Landes Bioscience and Springer."},{"key":"8575_CR40","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cobeha.2014.07.001","volume":"2","author":"E Rees","year":"2015","unstructured":"Rees, E., O\u2019Donovan, M. C., & Owen, M. J. (2015). Genetics of schizophrenia. Current Opinion in Behavioral Sciences,2, 8\u201314.","journal-title":"Current Opinion in Behavioral Sciences"},{"key":"8575_CR41","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.bbi.2006.11.009","volume":"21","author":"E Sacchetti","year":"2007","unstructured":"Sacchetti, E., Bocchio-Chiavetto, L., Valsecchi, P., Scassellati, C., Pasqualetti, P., Bonvicini, C., et al. (2007). G308A tumor necrosis factor alpha functional polymorphism and schizophrenia risk: Meta-analysis plus association study. Brain, Behavior, and Immunity,21, 450\u2013457.","journal-title":"Brain, Behavior, and Immunity"},{"issue":"7510","key":"8575_CR42","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature13595","volume":"511","author":"Schizophrenia Working Group of the Psychiatric Genomic Consortium","year":"2014","unstructured":"Schizophrenia Working Group of the Psychiatric Genomic Consortium. (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature,511(7510), 421\u2013427.","journal-title":"Nature"},{"key":"8575_CR43","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1097\/00003246-199907000-00006","volume":"27","author":"S Schroeder","year":"1999","unstructured":"Schroeder, S., Reck, M., Hoeft, A., & Stuber, F. (1999). Analysis of two human leukocyte antigen-linked polymorphic heat shock protein 70 genes in patients with severe sepsis. Critical Care Medicine,27, 1265\u20131270.","journal-title":"Critical Care Medicine"},{"key":"8575_CR44","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1176\/ajp.156.7.1103","volume":"156","author":"MJ Schwarz","year":"1999","unstructured":"Schwarz, M. J., Riedel, M., Gruber, R., Ackenheil, M., & M\u00fcller, N. (1999). Antibodies to heat shock proteins in schizophrenic patients: Implications for the mechanism of the disease. American Journal of Psychiatry,156, 1103\u20131104.","journal-title":"American Journal of Psychiatry"},{"key":"8575_CR45","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1097\/WNR.0b013e32832a2f32","volume":"20","author":"Y Terao","year":"2009","unstructured":"Terao, Y., Miyamoto, S., Hirai, K., Kamiguchi, H., Ohta, H., Shimojo, M., et al. (2009). Hypothermia enhances heat-shock protein 70 production in ischemic brains. NeuroReport,20, 745\u2013749.","journal-title":"NeuroReport"},{"key":"8575_CR46","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1227\/01.NEU.0000090341.38659.CF","volume":"53","author":"D Tsuchiya","year":"2003","unstructured":"Tsuchiya, D., Hong, S., Matsumori, Y., Kayama, T., Swanson, R. A., Dillman, W. H., et al. (2003). Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia and kainic acid-induced seizures. Neurosurgery,53, 1179\u20131187.","journal-title":"Neurosurgery"},{"key":"8575_CR47","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.biopsych.2011.01.003","volume":"69","author":"F Zhang","year":"2011","unstructured":"Zhang, F., Chen, Q., Ye, T., Lipska, B. K., Straub, R. E., Vakkalanka, R., et al. (2011). Evidence of sex-modulated association of ZNF804A with schizophrenia. Biological Psychiatry,69, 914\u2013947.","journal-title":"Biological Psychiatry"},{"key":"8575_CR48","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.schres.2005.10.011","volume":"81","author":"XY Zhang","year":"2006","unstructured":"Zhang, X. Y., Tan, Y. L., Cao, L. Y., Wu, G. Y., Xu, Q., Shen, Y., et al. (2006). Antioxidant enzymes and lipid peroxidation in different forms of schizophrenia treated with typical and atypical antipsychotics. Schizophrenia Research,81, 291\u2013300.","journal-title":"Schizophrenia Research"}],"container-title":["NeuroMolecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-019-08575-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12017-019-08575-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-019-08575-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T11:41:08Z","timestamp":1664710868000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12017-019-08575-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,23]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["8575"],"URL":"https:\/\/doi.org\/10.1007\/s12017-019-08575-1","relation":{},"ISSN":["1535-1084","1559-1174"],"issn-type":[{"value":"1535-1084","type":"print"},{"value":"1559-1174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,23]]},"assertion":[{"value":"17 October 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"We have no conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures followed were in accordance with the Bioethics Committee of Medical University of Silesia (No. KNW\/0022\/KB1\/38\/I\/12) and with the Helsinki Declaration of 1975, as revised in 2000.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All subjects had provided written consent prior to inclusion in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}