{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:56:27Z","timestamp":1786982187808,"version":"build-2736575974"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2018JJ6086"],"award-info":[{"award-number":["2018JJ6086"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuromol Med"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s12017-020-08605-3","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T15:03:24Z","timestamp":1595862204000},"page":"256-266","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Blockage of miR-485-5p on Cortical Neuronal Apoptosis Induced by Oxygen and Glucose Deprivation\/Reoxygenation Through Inactivating MAPK Pathway"],"prefix":"10.1007","volume":"23","author":[{"given":"Jiangliu","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suonan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4840-3151","authenticated-orcid":false,"given":"Xieli","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,27]]},"reference":[{"issue":"3","key":"8605_CR2","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1016\/j.bbrc.2016.08.116","volume":"478","author":"Z Chen","year":"2016","unstructured":"Chen, Z., Zhang, Z., et al. (2016). Hydrogen sulfide protects against TNF-alpha induced neuronal cell apoptosis through miR-485-5p\/TRADD signaling. Biochemical and Biophysical Research Communications, 478(3), 1304\u20131309.","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"8605_CR1","doi-asserted-by":"publisher","DOI":"10.2174\/1567202617666200415154822","author":"X Chen","year":"2020","unstructured":"Chen, X., Zhang, S., et al. (2020). MiR-485\u20135p promotes neuron survival through mediating Rac1\/Notch2 signaling pathway after cerebral ischemia\/reperfusion. Current Neurovascular Research. https:\/\/doi.org\/10.2174\/1567202617666200415154822.","journal-title":"Current Neurovascular Research"},{"key":"8605_CR3","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0509","author":"JE Cohen","year":"2014","unstructured":"Cohen, J. E., Lee, P. R., et al. (2014). Systematic identification of 3\u2032-UTR regulatory elements in activity-dependent mRNA stability in hippocampal neurons. Philosophical Transactions of the Royal Society B: Biological Sciences. https:\/\/doi.org\/10.1098\/rstb.2013.0509.","journal-title":"Philosophical Transactions of the Royal Society B: Biological Sciences"},{"issue":"2","key":"8605_CR4","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.bbrc.2019.04.161","volume":"514","author":"HY Gai","year":"2019","unstructured":"Gai, H. Y., Wu, C., et al. (2019). Long non-coding RNA CHRF modulates the progression of cerebral ischemia\/reperfusion injury via miR-126\/SOX6 signaling pathway. Biochemical and Biophysical Research Communications, 514(2), 550\u2013557.","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"8605_CR5","doi-asserted-by":"publisher","first-page":"109466","DOI":"10.1016\/j.cellsig.2019.109466","volume":"66","author":"J Gao","year":"2020","unstructured":"Gao, J., Dai, C., et al. (2020). microRNA-485-5p inhibits the progression of hepatocellular carcinoma through blocking the WBP2\/Wnt signaling pathway. Cellular Signalling, 66, 109466.","journal-title":"Cellular Signalling"},{"issue":"15","key":"8605_CR6","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.7150\/jca.24918","volume":"9","author":"XX Hu","year":"2018","unstructured":"Hu, X. X., Xu, X. N., et al. (2018). microRNA-485-5p functions as a tumor suppressor in colorectal cancer cells by targeting CD147. J Cancer, 9(15), 2603\u20132611.","journal-title":"J Cancer"},{"issue":"11","key":"8605_CR7","first-page":"3529","volume":"10","author":"Y Jiang","year":"2018","unstructured":"Jiang, Y., Xie, H., et al. (2018). Exosomes secreted by HUVECs attenuate hypoxia\/reoxygenation-induced apoptosis in neural cells by suppressing miR-21-3p. Am J Transl Res, 10(11), 3529\u20133541.","journal-title":"Am J Transl Res"},{"issue":"5","key":"8605_CR8","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1159\/000487873","volume":"45","author":"Y Liang","year":"2018","unstructured":"Liang, Y., Xu, J., et al. (2018). Inhibition of MiRNA-125b decreases cerebral ischemia\/reperfusion injury by targeting CK2alpha\/NADPH oxidase signaling. Cellular Physiology and Biochemistry, 45(5), 1818\u20131826.","journal-title":"Cellular Physiology and Biochemistry"},{"key":"8605_CR9","doi-asserted-by":"crossref","unstructured":"Liang, Z., Xu, J., et al. (2019). Novel role of the SRY-related high-mobility-group box D gene in cancer. In Seminars cancer biology. New York: Academic Press","DOI":"10.1016\/j.semcancer.2019.07.011"},{"issue":"2","key":"8605_CR10","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s13105-020-00730-8","volume":"76","author":"Q Liu","year":"2020","unstructured":"Liu, Q., Wang, Z., et al. (2020). miR-485-5p\/HSP90 axis blocks Akt1 phosphorylation to suppress osteosarcoma cell proliferation and migration via PI3K\/AKT pathway. Journal of Physiology and Biochemistry, 76(2), 279\u2013290.","journal-title":"Journal of Physiology and Biochemistry"},{"key":"8605_CR11","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.12659\/MSM.900218","volume":"23","author":"Y Liu","year":"2017","unstructured":"Liu, Y., Song, Y., et al. (2017). MicroRNA-181a regulates apoptosis and autophagy process in Parkinson's disease by inhibiting p38 mitogen-activated protein kinase (MAPK)\/c-Jun N-terminal kinases (JNK) signaling pathways. Medical Science Monitor, 23, 1597\u20131606.","journal-title":"Medical Science Monitor"},{"issue":"2","key":"8605_CR12","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.tins.2014.11.003","volume":"38","author":"S Lodato","year":"2015","unstructured":"Lodato, S., Shetty, A. S., et al. (2015). Cerebral cortex assembly: Generating and reprogramming projection neuron diversity. Trends in Neurosciences, 38(2), 117\u2013125.","journal-title":"Trends in Neurosciences"},{"key":"8605_CR13","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.nbd.2013.01.017","volume":"54","author":"CH Nijboer","year":"2013","unstructured":"Nijboer, C. H., Bonestroo, H. J., et al. (2013). Mitochondrial JNK phosphorylation as a novel therapeutic target to inhibit neuroinflammation and apoptosis after neonatal ischemic brain damage. Neurobiology of Diseases, 54, 432\u2013444.","journal-title":"Neurobiology of Diseases"},{"key":"8605_CR14","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.neuroscience.2017.10.046","volume":"367","author":"YB Pan","year":"2017","unstructured":"Pan, Y. B., Sun, Z. L., et al. (2017). The role of MicroRNA in traumatic brain injury. Neuroscience, 367, 189\u2013199.","journal-title":"Neuroscience"},{"issue":"7","key":"8605_CR15","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/s41419-018-0784-6","volume":"9","author":"S Piccirillo","year":"2018","unstructured":"Piccirillo, S., Castaldo, P., et al. (2018). Glutamate as a potential \"survival factor\" in an in vitro model of neuronal hypoxia\/reoxygenation injury: Leading role of the Na(+)\/Ca(2+) exchanger. Cell Death & Disease, 9(7), 731.","journal-title":"Cell Death & Disease"},{"key":"8605_CR16","doi-asserted-by":"publisher","first-page":"103129","DOI":"10.1016\/j.jri.2020.103129","volume":"140","author":"HF Qiao","year":"2020","unstructured":"Qiao, H. F., Liu, Y. L., et al. (2020). G-5555 synergized miR-485-5p to alleviate cisplatin resistance in ovarian cancer cells via Pi3k\/Akt signaling pathway. Journal of Reproductive Immunology, 140, 103129.","journal-title":"Journal of Reproductive Immunology"},{"issue":"2","key":"8605_CR17","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1515\/jbcpp-2013-0121","volume":"25","author":"A Siniscalchi","year":"2014","unstructured":"Siniscalchi, A., Gallelli, L., et al. (2014). Cerebral stroke injury: The role of cytokines and brain inflammation. Journal of Basic and Clinical Physiology and Pharmacology, 25(2), 131\u2013137.","journal-title":"Journal of Basic and Clinical Physiology and Pharmacology"},{"issue":"1","key":"8605_CR18","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.bbrc.2018.04.129","volume":"501","author":"M Wang","year":"2018","unstructured":"Wang, M., Cai, W. R., et al. (2018a). miR-485-5p suppresses breast cancer progression and chemosensitivity by targeting survivin. Biochemical and Biophysical Research Communications, 501(1), 48\u201354.","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"12","key":"8605_CR19","first-page":"2507","volume":"8","author":"R Wang","year":"2018","unstructured":"Wang, R., Zuo, X., et al. (2018b). MicroRNA-485-5p attenuates cell proliferation in glioma by directly targeting paired box 3. American Journal of Cancer Research, 8(12), 2507\u20132517.","journal-title":"American Journal of Cancer Research"},{"issue":"3","key":"8605_CR20","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s12264-019-00425-1","volume":"36","author":"XG Wang","year":"2019","unstructured":"Wang, X. G., Zhu, D. D., et al. (2019). Scorpion venom heat-resistant peptide is neuroprotective against cerebral ischemia-reperfusion injury in association with the NMDA-MAPK pathway. Neuroscience Bulletin, 36(3), 243\u2013253.","journal-title":"Neuroscience Bulletin"},{"issue":"9","key":"8605_CR21","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1038\/s41419-018-0937-7","volume":"9","author":"Y Wang","year":"2018","unstructured":"Wang, Y., Sun, L., et al. (2018c). Long non-coding RNA DSCR8 acts as a molecular sponge for miR-485-5p to activate Wnt\/beta-catenin signal pathway in hepatocellular carcinoma. Cell Death & Disease, 9(9), 851.","journal-title":"Cell Death & Disease"},{"issue":"9","key":"8605_CR22","doi-asserted-by":"publisher","first-page":"6632","DOI":"10.1002\/jcp.26297","volume":"233","author":"DM Wu","year":"2018","unstructured":"Wu, D. M., Zhang, Y. T., et al. (2018). Effects of microRNA-129 and its target gene c-Fos on proliferation and apoptosis of hippocampal neurons in rats with epilepsy via the MAPK signaling pathway. Journal of Cellular Physiology, 233(9), 6632\u20136643.","journal-title":"Journal of Cellular Physiology"},{"key":"8605_CR23","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.biopha.2017.03.064","volume":"90","author":"J Wu","year":"2017","unstructured":"Wu, J., Li, J., et al. (2017). MicroRNA-485-5p represses melanoma cell invasion and proliferation by suppressing Frizzled7. Biomedicine & Pharmacotherapy, 90, 303\u2013310.","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"11","key":"8605_CR24","doi-asserted-by":"publisher","first-page":"18901","DOI":"10.1002\/jcb.29210","volume":"120","author":"T Wu","year":"2019","unstructured":"Wu, T., Yin, F., et al. (2019). Germacrone attenuates cerebral ischemia\/reperfusion injury in rats via antioxidative and antiapoptotic mechanisms. Journal of Cellular Biochemistry, 120(11), 18901\u201318909.","journal-title":"Journal of Cellular Biochemistry"},{"key":"8605_CR25","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.3389\/fnins.2019.01036","volume":"13","author":"Q Yang","year":"2019","unstructured":"Yang, Q., Huang, Q., et al. (2019). Potential neuroprotective treatment of stroke: Targeting excitotoxicity, oxidative stress, and inflammation. Frontiers in Neuroscience, 13, 1036.","journal-title":"Frontiers in Neuroscience"},{"issue":"1","key":"8605_CR26","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12974-018-1053-4","volume":"15","author":"L Yao","year":"2018","unstructured":"Yao, L., Ye, Y., et al. (2018). MicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson's disease. Journal of Neuroinflammation, 15(1), 13.","journal-title":"Journal of Neuroinflammation"},{"issue":"22","key":"8605_CR27","doi-asserted-by":"publisher","first-page":"3095","DOI":"10.1080\/15384101.2019.1669388","volume":"18","author":"Z Zeng","year":"2019","unstructured":"Zeng, Z., Liu, Y., et al. (2019). MicroRNA-129-5p alleviates nerve injury and inflammatory response of Alzheimer's disease via downregulating SOX6. Cell Cycle, 18(22), 3095\u20133110.","journal-title":"Cell Cycle"},{"key":"8605_CR28","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.cbi.2019.06.008","volume":"308","author":"Y Zhang","year":"2019","unstructured":"Zhang, Y., Shan, Z., et al. (2019). Sevoflurane prevents miR-181a-induced cerebral ischemia\/reperfusion injury. Chemico-Biological Interactions, 308, 332\u2013338.","journal-title":"Chemico-Biological Interactions"},{"issue":"5","key":"8605_CR29","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.neuron.2010.02.018","volume":"65","author":"X Zhao","year":"2010","unstructured":"Zhao, X., He, X., et al. (2010). MicroRNA-mediated control of oligodendrocyte differentiation. Neuron, 65(5), 612\u2013626.","journal-title":"Neuron"},{"issue":"1","key":"8605_CR30","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s12964-019-0417-4","volume":"17","author":"Y Zheng","year":"2019","unstructured":"Zheng, Y., Wang, L., et al. (2019). Inhibition of T cell immunoglobulin and mucin-1 (TIM-1) protects against cerebral ischemia-reperfusion injury. Cell Communication and Signaling, 17(1), 103.","journal-title":"Cell Communication and Signaling"}],"container-title":["NeuroMolecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-020-08605-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12017-020-08605-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-020-08605-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T20:31:40Z","timestamp":1627331500000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12017-020-08605-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,27]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["8605"],"URL":"https:\/\/doi.org\/10.1007\/s12017-020-08605-3","relation":{},"ISSN":["1535-1084","1559-1174"],"issn-type":[{"value":"1535-1084","type":"print"},{"value":"1559-1174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,27]]},"assertion":[{"value":"1 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The author declares that they have nothing worth disclosure.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}