{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:34:03Z","timestamp":1789594443075,"version":"build-2803163510"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Shandong Medical and Health Science and Technology Development Plan","award":["2013WS0129"],"award-info":[{"award-number":["2013WS0129"]}]},{"name":"Central Financial Support for the Development of Special Funds for Local Colleges and Universities","award":["3500-112291"],"award-info":[{"award-number":["3500-112291"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuromol Med"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s12017-020-08606-2","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T13:05:53Z","timestamp":1603285553000},"page":"493-502","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Galuteolin Inhibited Autophagy for Neuroprotection Against Transient Focal Cerebral Ischemia in Rats"],"prefix":"10.1007","volume":"22","author":[{"given":"Juxun","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8679-5988","authenticated-orcid":false,"given":"Jinping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"issue":"6","key":"8606_CR1","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1042\/bj0170836","volume":"17","author":"G Barger","year":"1923","unstructured":"Barger, G., & White, F. D. (1923). Galuteolin, a new glucoside from Galega officinalis. Biochemical Journal, 17(6), 836.","journal-title":"Biochemical Journal"},{"key":"8606_CR2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/2040-7378-6-8","volume":"6","author":"KM Buckley","year":"2014","unstructured":"Buckley, K. M., Hess, D. L., Sazonova, I. Y., Periyasamy-Thandavan, S., Barrett, J. R., Kirks, R., et al. (2014). Rapamycin up-regulation of autophagy reduces infarct size and improves outcomes in both permanent MCAL, and embolic MCAO, murine models of stroke. Experimental & Translational Stroke Medicine, 6, 8. https:\/\/doi.org\/10.1186\/2040-7378-6-8.","journal-title":"Experimental & Translational Stroke Medicine"},{"issue":"11","key":"8606_CR3","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1007\/s11064-005-8510-z","volume":"30","author":"J Burda","year":"2005","unstructured":"Burda, J., Matia\u0161ov\u00e1, M., Gottlieb, M., Danielisova, V., Nemethova, M., Garcia, L., et al. (2005). Evidence for a role of second pathophysiological stress in prevention of delayed neuronal death in the hippocampal CA1 region. Neurochemical Research, 30(11), 1397\u20131405.","journal-title":"Neurochemical Research"},{"issue":"2","key":"8606_CR4","doi-asserted-by":"crossref","first-page":"e0148693","DOI":"10.1371\/journal.pone.0148693","volume":"11","author":"Z Cao","year":"2016","unstructured":"Cao, Z., Ding, Y., Ke, Z., Cao, L., Li, N., Ding, G., et al. (2016). Luteoloside acts as 3C protease inhibitor of enterovirus 71 in vitro. PLoS ONE, 11(2), e0148693.","journal-title":"PLoS ONE"},{"issue":"3","key":"8606_CR5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.nbd.2008.07.022","volume":"32","author":"S Carloni","year":"2008","unstructured":"Carloni, S., Buonocore, G., & Balduini, W. (2008). Protective role of autophagy in neonatal hypoxia\u2013ischemia induced brain injury. Neurobiology of Disease, 32(3), 329\u2013339.","journal-title":"Neurobiology of Disease"},{"issue":"12","key":"8606_CR6","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.4103\/1673-5374.135329","volume":"9","author":"W Chen","year":"2014","unstructured":"Chen, W., Sun, Y., Liu, K., & Sun, X. (2014). Autophagy: a double-edged sword for neuronal survival after cerebral ischemia. Neural Regeneration Research, 9(12), 1210.","journal-title":"Neural Regeneration Research"},{"issue":"2","key":"8606_CR7","doi-asserted-by":"crossref","first-page":"e89961","DOI":"10.1371\/journal.pone.0089961","volume":"9","author":"S-H Fan","year":"2014","unstructured":"Fan, S.-H., Wang, Y.-Y., Lu, J., Zheng, Y.-L., Wu, D.-M., Li, M.-Q., et al. (2014). Luteoloside suppresses proliferation and metastasis of hepatocellular carcinoma cells by inhibition of NLRP3 inflammasome. PLoS ONE, 9(2), e89961.","journal-title":"PLoS ONE"},{"issue":"8","key":"8606_CR8","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrn.2016.51","volume":"17","author":"L Galluzzi","year":"2016","unstructured":"Galluzzi, L., Bravo-San Pedro, J. M., Blomgren, K., & Kroemer, G. (2016). Autophagy in acute brain injury. Nature Reviews Neuroscience, 17(8), 467.","journal-title":"Nature Reviews Neuroscience"},{"issue":"9","key":"8606_CR9","doi-asserted-by":"crossref","first-page":"e46092","DOI":"10.1371\/journal.pone.0046092","volume":"7","author":"L Gao","year":"2012","unstructured":"Gao, L., Jiang, T., Guo, J., Liu, Y., Cui, G., Gu, L., et al. (2012). Inhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats. PLoS ONE, 7(9), e46092.","journal-title":"PLoS ONE"},{"key":"8606_CR10","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.biopha.2017.02.015","volume":"89","author":"X-P Huang","year":"2017","unstructured":"Huang, X.-P., Ding, H., Yang, X.-Q., Li, J.-X., Tang, B., Liu, X.-D., et al. (2017). Synergism and mechanism of Astragaloside IV combined with Ginsenoside Rg1 against autophagic injury of PC12 cells induced by oxygen glucose deprivation\/reoxygenation. Biomedicine & Pharmacotherapy, 89, 124\u2013134.","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"11","key":"8606_CR11","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1002\/2211-5463.12301","volume":"7","author":"WW Jiang","year":"2017","unstructured":"Jiang, W. W., Huang, B. S., Han, Y., Deng, L. H., & Wu, L. X. (2017). Sodium hydrosulfide attenuates cerebral ischemia\/reperfusion injury by suppressing overactivated autophagy in rats. FEBS Open Bio, 7(11), 1686\u20131695.","journal-title":"FEBS Open Bio"},{"issue":"1\u20132","key":"8606_CR12","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jns.2015.03.008","volume":"351","author":"J-C Lee","year":"2015","unstructured":"Lee, J.-C., Cho, J.-H., Kim, I. H., Ahn, J. H., Park, J. H., Cho, G.-S., et al. (2015). Ischemic preconditioning inhibits expression of Na+\/H+ exchanger 1 (NHE1) in the gerbil hippocampal CA1 region after transient forebrain ischemia. Journal of the Neurological Sciences, 351(1\u20132), 146\u2013153.","journal-title":"Journal of the Neurological Sciences"},{"issue":"5","key":"8606_CR13","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.neuint.2012.01.026","volume":"60","author":"M Li","year":"2012","unstructured":"Li, M., Qu, Y. Z., Zhao, Z. W., Wu, S. X., Liu, Y. Y., Wei, X. Y., et al. (2012). Astragaloside IV protects against focal cerebral ischemia\/reperfusion injury correlating to suppression of neutrophils adhesion-related molecules. Neurochemistry International, 60(5), 458\u2013465.","journal-title":"Neurochemistry International"},{"key":"8606_CR14","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.intimp.2018.11.044","volume":"66","author":"Q Li","year":"2019","unstructured":"Li, Q., Tian, Z., Wang, M., Kou, J., Wang, C., Rong, X., et al. (2019). Luteoloside attenuates neuroinflammation in focal cerebral ischemia in rats via regulation of the PPAR\u03b3\/Nrf2\/NF-\u03baB signaling pathway. International Immunopharmacology, 66, 309\u2013316.","journal-title":"International Immunopharmacology"},{"issue":"3","key":"8606_CR15","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/cdd.2014.143","volume":"22","author":"Y Liu","year":"2015","unstructured":"Liu, Y., & Levine, B. (2015). Autosis and autophagic cell death: the dark side of autophagy. Cell Death and Differentiation, 22(3), 367.","journal-title":"Cell Death and Differentiation"},{"issue":"1","key":"8606_CR16","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","volume":"20","author":"EZ Longa","year":"1989","unstructured":"Longa, E. Z., Weinstein, P. R., Carlson, S., & Cummins, R. (1989). Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke, 20(1), 84\u201391.","journal-title":"Stroke"},{"key":"8606_CR17","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.redox.2015.06.016","volume":"6","author":"Q Lu","year":"2015","unstructured":"Lu, Q., Harris, V. A., Kumar, S., Mansour, H. M., & Black, S. M. (2015). Autophagy in neonatal hypoxia ischemic brain is associated with oxidative stress. Redox Biology, 6, 516\u2013523.","journal-title":"Redox Biology"},{"key":"8606_CR18","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neuroscience.2015.03.050","volume":"297","author":"C Nocjar","year":"2015","unstructured":"Nocjar, C., Alex, K. D., Sonneborn, A., Abbas, A. I., Roth, B. L., & Pehek, E. A. (2015). Serotonin-2C and-2a receptor co-expression on cells in the rat medial prefrontal cortex. Neuroscience, 297, 22\u201337.","journal-title":"Neuroscience"},{"issue":"1","key":"8606_CR19","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.nbd.2007.08.005","volume":"29","author":"A Rami","year":"2008","unstructured":"Rami, A., Langhagen, A., & Steiger, S. (2008). Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death. Neurobiology of Disease, 29(1), 132\u2013141.","journal-title":"Neurobiology of Disease"},{"issue":"2","key":"8606_CR20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ana.410090206","volume":"9","author":"JE Rice","year":"1981","unstructured":"Rice, J. E., Vannucci, R. C., & Brierley, J. B. (1981). The influence of immaturity on hypoxic-ischemic brain damage in the rat. Annals of Neurology, 9(2), 131\u2013141.","journal-title":"Annals of Neurology"},{"issue":"2","key":"8606_CR21","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1002\/jcp.26084","volume":"233","author":"F Song","year":"2018","unstructured":"Song, F., Wei, C., Zhou, L., Qin, A., Yang, M., Tickner, J., et al. (2018). Luteoloside prevents lipopolysaccharide-induced osteolysis and suppresses RANKL-induced osteoclastogenesis through attenuating RANKL signaling cascades. Journal of Cellular Physiology, 233(2), 1723\u20131735.","journal-title":"Journal of Cellular Physiology"},{"key":"8606_CR22","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jep.2014.11.015","volume":"159","author":"T-C Tsai","year":"2015","unstructured":"Tsai, T.-C., Tung, Y.-T., Kuo, Y.-H., Liao, J.-W., Tsai, H.-C., Chong, K.-Y., et al. (2015). Anti-inflammatory effects of Antrodia camphorata, a herbal medicine, in a mouse skin ischemia model. Journal of Ethnopharmacology, 159, 113\u2013121.","journal-title":"Journal of Ethnopharmacology"},{"issue":"4","key":"8606_CR23","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1203\/00006450-199004000-00001","volume":"27","author":"RC Vannucci","year":"1990","unstructured":"Vannucci, R. C. (1990). Experimental biology of cerebral hypoxia-ischemia: Relation to perinatal brain damage. Pediatric Research, 27(4), 317.","journal-title":"Pediatric Research"},{"issue":"5","key":"8606_CR24","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1007\/s10753-018-0814-7","volume":"41","author":"X Wang","year":"2018","unstructured":"Wang, X., Yuan, T., Yin, N., Ma, X., Zhang, Z., Zhu, Z., et al. (2018). Luteoloside protects the uterus from Staphylococcus aureus-induced inflammation, apoptosis, and injury. Inflammation, 41(5), 1702\u20131716.","journal-title":"Inflammation"},{"issue":"4","key":"8606_CR25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1017\/S031716710001218X","volume":"38","author":"X-Y Xin","year":"2011","unstructured":"Xin, X.-Y., Pan, J., Wang, X.-Q., Ma, J.-F., Ding, J.-Q., Yang, G.-Y., et al. (2011). 2-Methoxyestradiol attenuates autophagy activation after global ischemia. Canadian Journal of Neurological Sciences, 38(4), 631\u2013638.","journal-title":"Canadian Journal of Neurological Sciences"},{"issue":"5","key":"8606_CR26","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/jnc.13851","volume":"139","author":"Y Xu","year":"2016","unstructured":"Xu, Y., Tian, Y., Tian, Y., Li, X., & Zhao, P. (2016). Autophagy activation involved in hypoxic-ischemic brain injury induces cognitive and memory impairment in neonatal rats. Journal of Neurochemistry, 139(5), 795\u2013805.","journal-title":"Journal of Neurochemistry"},{"issue":"5","key":"8606_CR27","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1248\/bpb.24.558","volume":"24","author":"W Xuejiang","year":"2001","unstructured":"Xuejiang, W., Ichikawa, H., & Konishi, T. (2001). Antioxidant potential of Qizhu Tang, a Chinese Herbal Medicine, and the effect of cerebral oxidative damage after ischemia reperfusion in rats. Biological and Pharmaceutical Bulletin, 24(5), 558\u2013563.","journal-title":"Biological and Pharmaceutical Bulletin"},{"issue":"5","key":"8606_CR28","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1080\/10715769900301011","volume":"31","author":"W Xuejiang","year":"1999","unstructured":"Xuejiang, W., Magara, T., & Konishi, T. (1999). Prevention and repair of cerebral ischemia-reperfusion injury by Chinese herbal medicine, shengmai san, in rats. Free Radical Research, 31(5), 449\u2013455.","journal-title":"Free Radical Research"},{"issue":"9","key":"8606_CR29","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.4161\/auto.25132","volume":"9","author":"X Zhang","year":"2013","unstructured":"Zhang, X., Yan, H., Yuan, Y., Gao, J., Shen, Z., Cheng, Y., et al. (2013). Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance. Autophagy, 9(9), 1321\u20131333.","journal-title":"Autophagy"}],"container-title":["NeuroMolecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-020-08606-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12017-020-08606-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-020-08606-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T23:45:33Z","timestamp":1634773533000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12017-020-08606-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,21]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["8606"],"URL":"https:\/\/doi.org\/10.1007\/s12017-020-08606-2","relation":{},"ISSN":["1535-1084","1559-1174"],"issn-type":[{"value":"1535-1084","type":"print"},{"value":"1559-1174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,21]]},"assertion":[{"value":"9 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Animal Ethics Committee of Shandong Provincial Qianfoshan Hospital. All procedures performed in studies involving animals were conducted according to the guidelines for the use of laboratory animals in China.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}