{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:40:28Z","timestamp":1780461628976,"version":"3.54.1"},"reference-count":99,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T00:00:00Z","timestamp":1625270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T00:00:00Z","timestamp":1625270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100006827","name":"Florida Department of Health","doi-asserted-by":"crossref","award":["7JK01"],"award-info":[{"award-number":["7JK01"]}],"id":[{"id":"10.13039\/100006827","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Florida Department of Heath","award":["20K09"],"award-info":[{"award-number":["20K09"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuromol Med"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s12017-021-08666-y","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T03:35:27Z","timestamp":1625283327000},"page":"62-73","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Irisin-Associated Neuroprotective and Rehabilitative Strategies for Stroke"],"prefix":"10.1007","volume":"24","author":[{"given":"Melissa Ann","family":"Huberman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan D.","family":"d\u2019Adesky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qismat Bahar","family":"Niazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Perez-Pinzon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M.","family":"Bramlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1757-9947","authenticated-orcid":false,"given":"Ami P.","family":"Raval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,3]]},"reference":[{"key":"8666_CR1","volume-title":"Using whole body vibration in physical therapy and sport: Clinical practice and treatment exercises","author":"A Albasini","year":"2010","unstructured":"Albasini, A., Krause, M., & Rembitzki, I. V. (2010). Using whole body vibration in physical therapy and sport: Clinical practice and treatment exercises. Churchill Livingstone\/Elsevier."},{"issue":"1","key":"8666_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13539-014-0135-0","volume":"5","author":"SD Anker","year":"2014","unstructured":"Anker, S. D., Coats, A. J., Morley, J. E., Rosano, G., Bernabei, R., von Haehling, S., & Kalantar-Zadeh, K. (2014). Muscle wasting disease: A proposal for a new disease classification. Journal of Cachexia, Sarcopenia and Muscle, 5(1), 1\u20133. https:\/\/doi.org\/10.1007\/s13539-014-0135-0","journal-title":"Journal of Cachexia, Sarcopenia and Muscle"},{"issue":"8","key":"8666_CR3","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1007\/s11064-018-2569-9","volume":"43","author":"Y Asadi","year":"2018","unstructured":"Asadi, Y., Gorjipour, F., Behrouzifar, S., & Vakili, A. (2018). Irisin peptide protects brain against ischemic injury through reducing apoptosis and enhancing BDNF in a rodent model of stroke. Neurochemical Research, 43(8), 1549\u20131560. https:\/\/doi.org\/10.1007\/s11064-018-2569-9","journal-title":"Neurochemical Research"},{"key":"8666_CR4","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.peptides.2014.09.014","volume":"61","author":"S Aydin","year":"2014","unstructured":"Aydin, S., Kuloglu, T., Aydin, S., Kalayci, M., Yilmaz, M., Cakmak, T., Albayrak, S., Gungor, S., Colakoglu, N., & Ozercan, I. H. (2014). A comprehensive immunohistochemical examination of the distribution of the fat-burning protein irisin in biological tissues. Peptides, 61, 130\u2013136. https:\/\/doi.org\/10.1016\/j.peptides.2014.09.014","journal-title":"Peptides"},{"issue":"3","key":"8666_CR5","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1097\/gme.0b013e3181c7dd41","volume":"17","author":"Y Baba","year":"2010","unstructured":"Baba, Y., Ishikawa, S., Amagi, Y., Kayaba, K., Gotoh, T., & Kajii, E. (2010). Premature menopause is associated with increased risk of cerebral infarction in Japanese women. Menopause, 17(3), 506\u2013510. https:\/\/doi.org\/10.1097\/gme.0b013e3181c7dd41","journal-title":"Menopause"},{"issue":"7382","key":"8666_CR6","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nature10777","volume":"481","author":"P Bostrom","year":"2012","unstructured":"Bostrom, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Bostrom, E. A., Choi, J. H., Long, J. Z., Kajimura, S., Zingaretti, M. C., Vind, B. F., Tu, H., Cinti, S., Hojlund, K., Gygi, S. P., & Spiegelman, B. M. (2012). A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature, 481(7382), 463\u2013468. https:\/\/doi.org\/10.1038\/nature10777","journal-title":"Nature"},{"issue":"9","key":"8666_CR7","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1007\/s00198-014-2748-8","volume":"25","author":"HM Bramlett","year":"2014","unstructured":"Bramlett, H. M., Dietrich, W. D., Marcillo, A., Mawhinney, L. J., Furones-Alonso, O., Bregy, A., Peng, Y., Wu, Y., Pan, J., Wang, J., Guo, X. E., Bauman, W. A., Cardozo, C., & Qin, W. (2014). Effects of low intensity vibration on bone and muscle in rats with spinal cord injury. Osteoporosis International, 25(9), 2209\u20132219. https:\/\/doi.org\/10.1007\/s00198-014-2748-8","journal-title":"Osteoporosis International"},{"issue":"2","key":"8666_CR8","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1152\/advan.90111.2008","volume":"32","author":"M Brown","year":"2008","unstructured":"Brown, M. (2008). Skeletal muscle and bone: Effect of sex steroids and aging. Advances in Physiology Education, 32(2), 120\u2013126. https:\/\/doi.org\/10.1152\/advan.90111.2008","journal-title":"Advances in Physiology Education"},{"issue":"12","key":"8666_CR9","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1177\/0271678X18793324","volume":"38","author":"CD Bushnell","year":"2018","unstructured":"Bushnell, C. D., Chaturvedi, S., Gage, K. R., Herson, P. S., Hurn, P. D., Jimenez, M. C., Kittner, S. J., Madsen, T. E., McCullough, L. D., McDermott, M., Reeves, M. J., & Rundek, T. (2018). Sex differences in stroke: Challenges and opportunities. Journal of Cerebral Blood Flow and Metabolism, 38(12), 2179\u20132191. https:\/\/doi.org\/10.1177\/0271678X18793324","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"issue":"12","key":"8666_CR10","doi-asserted-by":"publisher","first-page":"1164 e1167","DOI":"10.1016\/j.jamda.2016.09.013","volume":"17","author":"KV Chang","year":"2016","unstructured":"Chang, K. V., Hsu, T. H., Wu, W. T., Huang, K. C., & Han, D. S. (2016). Association between sarcopenia and cognitive impairment: A systematic review and meta-analysis. Journal of the American Medical Directors Association, 17(12), 1164 e1167-1164 e1115. https:\/\/doi.org\/10.1016\/j.jamda.2016.09.013","journal-title":"Journal of the American Medical Directors Association"},{"issue":"5","key":"8666_CR11","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/S1474-4422(19)30034-1","volume":"18","author":"GBDS Collaborators","year":"2019","unstructured":"Collaborators, G. B. D. S. (2019). Global, regional, and national burden of stroke, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurology, 18(5), 439\u2013458. https:\/\/doi.org\/10.1016\/S1474-4422(19)30034-1","journal-title":"Lancet Neurology"},{"issue":"1","key":"8666_CR12","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/ageing\/afy169","volume":"48","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft, A. J., Bahat, G., Bauer, J., Boirie, Y., Bruyere, O., Cederholm, T., Cooper, C., Landi, F., Rolland, Y., Sayer, A. A., Schneider, S. M., Sieber, C. C., Topinkova, E., Vandewoude, M., Visser, M., Zamboni, M., Writing Group for the European Working Group on Sarcopenia in Older, P., & the Extended Group for, E. (2019). Sarcopenia: Revised European consensus on definition and diagnosis. Age and Ageing, 48(1), 16\u201331. https:\/\/doi.org\/10.1093\/ageing\/afy169","journal-title":"Age and Ageing"},{"key":"8666_CR13","doi-asserted-by":"publisher","first-page":"15004","DOI":"10.1038\/nrdp.2015.4","volume":"1","author":"SR Davis","year":"2015","unstructured":"Davis, S. R., Lambrinoudaki, I., Lumsden, M., Mishra, G. D., Pal, L., Rees, M., Santoro, N., & Simoncini, T. (2015). Menopause. Nature Reviews. Disease Primers, 1, 15004. https:\/\/doi.org\/10.1038\/nrdp.2015.4","journal-title":"Nature Reviews. Disease Primers"},{"issue":"2","key":"8666_CR14","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/mus.20085","volume":"30","author":"PG De Deyne","year":"2004","unstructured":"De Deyne, P. G., Hafer-Macko, C. E., Ivey, F. M., Ryan, A. S., & Macko, R. F. (2004). Muscle molecular phenotype after stroke is associated with gait speed. Muscle and Nerve, 30(2), 209\u2013215. https:\/\/doi.org\/10.1002\/mus.20085","journal-title":"Muscle and Nerve"},{"issue":"6","key":"8666_CR15","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1111\/jnc.15039","volume":"155","author":"GB de Freitas","year":"2020","unstructured":"de Freitas, G. B., Lourenco, M. V., & De Felice, F. G. (2020). Protective actions of exercise-related FNDC5\/Irisin in memory and Alzheimer\u2019s disease. Journal of Neurochemistry, 155(6), 602\u2013611. https:\/\/doi.org\/10.1111\/jnc.15039","journal-title":"Journal of Neurochemistry"},{"key":"8666_CR16","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13404","author":"JP de Rivero Vaccari","year":"2015","unstructured":"de Rivero Vaccari, J. P., Patel, H. H., Brand, F. J., 3rd., Perez-Pinzon, M. A., Bramlett, H. M., & Raval, A. P. (2015). Estrogen receptor beta signaling alters cellular inflammasomes activity after global cerebral ischemia in reproductively senescence female rats. Journal of Neurochemistry. https:\/\/doi.org\/10.1111\/jnc.13404","journal-title":"Journal of Neurochemistry"},{"key":"8666_CR17","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.029405","author":"N Dhanesha","year":"2020","unstructured":"Dhanesha, N., Schnell, T., Rahmatalla, S., DeShaw, J., Thedens, D., Parker, B. M., Zimmerman, M. B., Pieper, A. A., Chauhan, A. K., & Leira, E. C. (2020). Low-frequency vibrations enhance thrombolytic therapy and improve stroke outcomes. Stroke. https:\/\/doi.org\/10.1161\/STROKEAHA.120.029405","journal-title":"Stroke"},{"issue":"1","key":"8666_CR18","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.cger.2016.08.002","volume":"33","author":"RJ Dhillon","year":"2017","unstructured":"Dhillon, R. J., & Hasni, S. (2017). Pathogenesis and management of sarcopenia. Clinics in Geriatric Medicine, 33(1), 17\u201326. https:\/\/doi.org\/10.1016\/j.cger.2016.08.002","journal-title":"Clinics in Geriatric Medicine"},{"key":"8666_CR19","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.neuroscience.2013.02.050","volume":"240","author":"SL Dun","year":"2013","unstructured":"Dun, S. L., Lyu, R. M., Chen, Y. H., Chang, J. K., Luo, J. J., & Dun, N. J. (2013). Irisin-immunoreactivity in neural and non-neural cells of the rodent. Neuroscience, 240, 155\u2013162. https:\/\/doi.org\/10.1016\/j.neuroscience.2013.02.050","journal-title":"Neuroscience"},{"issue":"9","key":"8666_CR20","doi-asserted-by":"publisher","first-page":"e100","DOI":"10.1161\/01.STR.0000180861.54180.FF","volume":"36","author":"PW Duncan","year":"2005","unstructured":"Duncan, P. W., Zorowitz, R., Bates, B., Choi, J. Y., Glasberg, J. J., Graham, G. D., Katz, R. C., Lamberty, K., & Reker, D. (2005). Management of Adult Stroke Rehabilitation Care: A clinical practice guideline. Stroke, 36(9), e100-143. https:\/\/doi.org\/10.1161\/01.STR.0000180861.54180.FF","journal-title":"Stroke"},{"issue":"1","key":"8666_CR21","doi-asserted-by":"publisher","first-page":"44","DOI":"10.4070\/kcj.2016.0079","volume":"47","author":"TH Efe","year":"2017","unstructured":"Efe, T. H., Acar, B., Ertem, A. G., Yayla, K. G., Algul, E., Yayla, C., Unal, S., Bilgin, M., Cimen, T., Kirbas, O., & Yeter, E. (2017). Serum irisin level can predict the severity of coronary artery disease in patients with stable angina. Korean Circ J, 47(1), 44\u201349. https:\/\/doi.org\/10.4070\/kcj.2016.0079","journal-title":"Korean Circ J"},{"issue":"4","key":"8666_CR22","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.cmet.2010.03.008","volume":"11","author":"S Enerback","year":"2010","unstructured":"Enerback, S. (2010). Human brown adipose tissue. Cell Metabolism, 11(4), 248\u2013252. https:\/\/doi.org\/10.1016\/j.cmet.2010.03.008","journal-title":"Cell Metabolism"},{"issue":"1","key":"8666_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13539-011-0025-7","volume":"2","author":"K Fearon","year":"2011","unstructured":"Fearon, K., Evans, W. J., & Anker, S. D. (2011). Myopenia-a new universal term for muscle wasting. Journal of Cachexia, Sarcopenia and Muscle, 2(1), 1\u20133. https:\/\/doi.org\/10.1007\/s13539-011-0025-7","journal-title":"Journal of Cachexia, Sarcopenia and Muscle"},{"issue":"2","key":"8666_CR24","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1002\/dvdy.10099","volume":"224","author":"A Ferrer-Martinez","year":"2002","unstructured":"Ferrer-Martinez, A., Ruiz-Lozano, P., & Chien, K. R. (2002). Mouse PeP: A novel peroxisomal protein linked to myoblast differentiation and development. Developmental Dynamics, 224(2), 154\u2013167. https:\/\/doi.org\/10.1002\/dvdy.10099","journal-title":"Developmental Dynamics"},{"issue":"1","key":"8666_CR25","doi-asserted-by":"publisher","first-page":"42","DOI":"10.2340\/16501977-0129","volume":"40","author":"UB Flansbjer","year":"2008","unstructured":"Flansbjer, U. B., Miller, M., Downham, D., & Lexell, J. (2008). Progressive resistance training after stroke: Effects on muscle strength, muscle tone, gait performance and perceived participation. Journal of Rehabilitation Medicine, 40(1), 42\u201348. https:\/\/doi.org\/10.2340\/16501977-0129","journal-title":"Journal of Rehabilitation Medicine"},{"issue":"1","key":"8666_CR26","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s12877-019-1115-1","volume":"19","author":"A Gingrich","year":"2019","unstructured":"Gingrich, A., Volkert, D., Kiesswetter, E., Thomanek, M., Bach, S., Sieber, C. C., & Zopf, Y. (2019). Prevalence and overlap of sarcopenia, frailty, cachexia and malnutrition in older medical inpatients. BMC Geriatrics, 19(1), 120. https:\/\/doi.org\/10.1186\/s12877-019-1115-1","journal-title":"BMC Geriatrics"},{"issue":"1","key":"8666_CR27","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1186\/s12974-018-1282-6","volume":"15","author":"Z Gong","year":"2018","unstructured":"Gong, Z., Pan, J., Shen, Q., Li, M., & Peng, Y. (2018). Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia\/reperfusion injury. Journal of Neuroinflammation, 15(1), 242. https:\/\/doi.org\/10.1186\/s12974-018-1282-6","journal-title":"Journal of Neuroinflammation"},{"key":"8666_CR28","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/1471-2466-14-60","volume":"14","author":"T Greulich","year":"2014","unstructured":"Greulich, T., Nell, C., Koepke, J., Fechtel, J., Franke, M., Schmeck, B., Haid, D., Apelt, S., Filipovic, S., Kenn, K., Janciauskiene, S., Vogelmeier, C., & Koczulla, A. R. (2014). Benefits of whole body vibration training in patients hospitalised for COPD exacerbations\u2014A randomized clinical trial. BMC Pulmonary Medicine, 14, 60. https:\/\/doi.org\/10.1186\/1471-2466-14-60","journal-title":"BMC Pulmonary Medicine"},{"issue":"20","key":"8666_CR29","first-page":"4687","volume":"21","author":"B Grygiel-Gorniak","year":"2017","unstructured":"Grygiel-Gorniak, B., & Puszczewicz, M. (2017). A review on irisin, a new protagonist that mediates muscle-adipose-bone-neuron connectivity. European Review for Medical and Pharmacological Sciences, 21(20), 4687\u20134693.","journal-title":"European Review for Medical and Pharmacological Sciences"},{"issue":"10","key":"8666_CR30","doi-asserted-by":"publisher","first-page":"e01425","DOI":"10.1002\/brb3.1425","volume":"9","author":"P Guo","year":"2019","unstructured":"Guo, P., Jin, Z., Wu, H., Li, X., Ke, J., Zhang, Z., & Zhao, Q. (2019). Effects of irisin on the dysfunction of blood-brain barrier in rats after focal cerebral ischemia\/reperfusion. Brain and Behavior: A Cognitive Neuroscience Perspective, 9(10), e01425. https:\/\/doi.org\/10.1002\/brb3.1425","journal-title":"Brain and Behavior: A Cognitive Neuroscience Perspective"},{"issue":"2","key":"8666_CR31","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1682\/jrrd.2007.02.0040","volume":"45","author":"CE Hafer-Macko","year":"2008","unstructured":"Hafer-Macko, C. E., Ryan, A. S., Ivey, F. M., & Macko, R. F. (2008). Skeletal muscle changes after hemiparetic stroke and potential beneficial effects of exercise intervention strategies. Journal of Rehabilitation Research and Development, 45(2), 261\u2013272. https:\/\/doi.org\/10.1682\/jrrd.2007.02.0040","journal-title":"Journal of Rehabilitation Research and Development"},{"issue":"7203","key":"8666_CR32","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nature07206","volume":"454","author":"C Handschin","year":"2008","unstructured":"Handschin, C., & Spiegelman, B. M. (2008). The role of exercise and PGC1alpha in inflammation and chronic disease. Nature, 454(7203), 463\u2013469. https:\/\/doi.org\/10.1038\/nature07206","journal-title":"Nature"},{"issue":"7","key":"8666_CR33","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.metabol.2014.04.001","volume":"63","author":"JY Huh","year":"2014","unstructured":"Huh, J. Y., Mougios, V., Skraparlis, A., Kabasakalis, A., & Mantzoros, C. S. (2014). Irisin in response to acute and chronic whole-body vibration exercise in humans. Metabolism, 63(7), 918\u2013921. https:\/\/doi.org\/10.1016\/j.metabol.2014.04.001","journal-title":"Metabolism"},{"issue":"12","key":"8666_CR34","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1016\/j.metabol.2012.09.002","volume":"61","author":"JY Huh","year":"2012","unstructured":"Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012). FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism, 61(12), 1725\u20131738. https:\/\/doi.org\/10.1016\/j.metabol.2012.09.002","journal-title":"Metabolism"},{"issue":"2","key":"8666_CR35","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s00774-019-01043-7","volume":"38","author":"S Iemura","year":"2020","unstructured":"Iemura, S., Kawao, N., Okumoto, K., Akagi, M., & Kaji, H. (2020). Role of irisin in androgen-deficient muscle wasting and osteopenia in mice. Journal of Bone and Mineral Metabolism, 38(2), 161\u2013171. https:\/\/doi.org\/10.1007\/s00774-019-01043-7","journal-title":"Journal of Bone and Mineral Metabolism"},{"issue":"3","key":"8666_CR36","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1161\/STR.0b013e318284056a","volume":"44","author":"EC Jauch","year":"2013","unstructured":"Jauch, E. C., Saver, J. L., Adams, H. P., Jr., Bruno, A., Connors, J. J., Demaerschalk, B. M., Khatri, P., McMullan, P. W., Jr., Qureshi, A. I., Rosenfield, K., Scott, P. A., Summers, D. R., Wang, D. Z., Wintermark, M., Yonas, H., American Heart Association Stroke, C., Council on Cardiovascular, N., Council on Peripheral Vascular, D., & Council on Clinical, C. (2013). Guidelines for the early management of patients with acute ischemic stroke: A guideline for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke, 44(3), 870\u2013947. https:\/\/doi.org\/10.1161\/STR.0b013e318284056a","journal-title":"Stroke"},{"issue":"4","key":"8666_CR37","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/j.cmet.2015.08.001","volume":"22","author":"MP Jedrychowski","year":"2015","unstructured":"Jedrychowski, M. P., Wrann, C. D., Paulo, J. A., Gerber, K. K., Szpyt, J., Robinson, M. M., Nair, K. S., Gygi, S. P., & Spiegelman, B. M. (2015). Detection and quantitation of circulating human irisin by tandem mass spectrometry. Cell Metabolism, 22(4), 734\u2013740. https:\/\/doi.org\/10.1016\/j.cmet.2015.08.001","journal-title":"Cell Metabolism"},{"issue":"2","key":"8666_CR38","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S1474-4422(10)70277-5","volume":"10","author":"D Kapogiannis","year":"2011","unstructured":"Kapogiannis, D., & Mattson, M. P. (2011). Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer\u2019s disease. Lancet Neurology, 10(2), 187\u2013198. https:\/\/doi.org\/10.1016\/S1474-4422(10)70277-5","journal-title":"Lancet Neurology"},{"issue":"4","key":"8666_CR39","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.ogc.2018.07.012","volume":"45","author":"AS Karlamangla","year":"2018","unstructured":"Karlamangla, A. S., Burnett-Bowie, S. M., & Crandall, C. J. (2018). Bone health during the menopause transition and beyond. Obstetrics and Gynecology Clinics of North America, 45(4), 695\u2013708. https:\/\/doi.org\/10.1016\/j.ogc.2018.07.012","journal-title":"Obstetrics and Gynecology Clinics of North America"},{"key":"8666_CR40","doi-asserted-by":"publisher","first-page":"309","DOI":"10.3389\/fnmol.2018.00309","volume":"11","author":"N Kerr","year":"2018","unstructured":"Kerr, N., Garcia-Contreras, M., Abbassi, S., Mejias, N. H., Desousa, B. R., Ricordi, C., Dietrich, W. D., Keane, R. W., & de Rivero Vaccari, J. P. (2018a). Inflammasome proteins in serum and serum-derived extracellular vesicles as biomarkers of stroke. Frontiers in Molecular Neuroscience, 11, 309. https:\/\/doi.org\/10.3389\/fnmol.2018.00309","journal-title":"Frontiers in Molecular Neuroscience"},{"issue":"12","key":"8666_CR41","doi-asserted-by":"publisher","first-page":"e0210128","DOI":"10.1371\/journal.pone.0210128","volume":"13","author":"N Kerr","year":"2018","unstructured":"Kerr, N., Lee, S. W., Perez-Barcena, J., Crespi, C., Ibanez, J., Bullock, M. R., Dietrich, W. D., Keane, R. W., & de Rivero Vaccari, J. P. (2018b). Inflammasome proteins as biomarkers of traumatic brain injury. PLoS ONE, 13(12), e0210128. https:\/\/doi.org\/10.1371\/journal.pone.0210128","journal-title":"PLoS ONE"},{"issue":"2","key":"8666_CR42","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s13224-019-01213-7","volume":"69","author":"SS Khadilkar","year":"2019","unstructured":"Khadilkar, S. S. (2019). Musculoskeletal disorders and menopause. Journal of Obstetrics and Gynaecology of India, 69(2), 99\u2013103. https:\/\/doi.org\/10.1007\/s13224-019-01213-7","journal-title":"Journal of Obstetrics and Gynaecology of India"},{"issue":"7","key":"8666_CR43","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1016\/j.cell.2018.10.025","volume":"175","author":"H Kim","year":"2018","unstructured":"Kim, H., Wrann, C. D., Jedrychowski, M., Vidoni, S., Kitase, Y., Nagano, K., Zhou, C., Chou, J., Parkman, V. A., Novick, S. J., Strutzenberg, T. S., Pascal, B. D., Le, P. T., Brooks, D. J., Roche, A. M., Gerber, K. K., Mattheis, L., Chen, W., Tu, H., \u2026 Spiegelman, B. M. (2018). Irisin mediates effects on bone and fat via alphaV integrin receptors. Cell, 175(7), 1756\u20131768. https:\/\/doi.org\/10.1016\/j.cell.2018.10.025","journal-title":"Cell"},{"key":"8666_CR44","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.exger.2015.07.006","volume":"70","author":"HJ Kim","year":"2015","unstructured":"Kim, H. J., So, B., Choi, M., Kang, D., & Song, W. (2015). Resistance exercise training increases the expression of irisin concomitant with improvement of muscle function in aging mice and humans. Experimental Gerontology, 70, 11\u201317. https:\/\/doi.org\/10.1016\/j.exger.2015.07.006","journal-title":"Experimental Gerontology"},{"key":"8666_CR45","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8050121","author":"Y Kim","year":"2019","unstructured":"Kim, Y., Park, J., & Choi, Y. K. (2019). The role of astrocytes in the central nervous system focused on BK channel and heme oxygenase metabolites: A review. Antioxidants. https:\/\/doi.org\/10.3390\/antiox8050121","journal-title":"Antioxidants"},{"issue":"6","key":"8666_CR46","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1210\/me.2014-1353","volume":"29","author":"HJ Lee","year":"2015","unstructured":"Lee, H. J., Lee, J. O., Kim, N., Kim, J. K., Kim, H. I., Lee, Y. W., Kim, S. J., Choi, J. I., Oh, Y., Kim, J. H., Suyeon, H., Park, S. H., & Kim, H. S. (2015). Irisin, a novel myokine, regulates glucose uptake in skeletal muscle cells via AMPK. Molecular Endocrinology, 29(6), 873\u2013881. https:\/\/doi.org\/10.1210\/me.2014-1353","journal-title":"Molecular Endocrinology"},{"key":"8666_CR47","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.metabol.2016.12.003","volume":"68","author":"DJ Li","year":"2017","unstructured":"Li, D. J., Li, Y. H., Yuan, H. B., Qu, L. F., & Wang, P. (2017). The novel exercise-induced hormone irisin protects against neuronal injury via activation of the Akt and ERK1\/2 signaling pathways and contributes to the neuroprotection of physical exercise in cerebral ischemia. Metabolism, 68, 31\u201342. https:\/\/doi.org\/10.1016\/j.metabol.2016.12.003","journal-title":"Metabolism"},{"issue":"9","key":"8666_CR48","doi-asserted-by":"publisher","first-page":"4381","DOI":"10.7150\/thno.53652","volume":"11","author":"DJ Li","year":"2021","unstructured":"Li, D. J., Sun, S. J., Fu, J. T., Ouyang, S. X., Zhao, Q. J., Su, L., Ji, Q. X., Sun, D. Y., Zhu, J. H., Zhang, G. Y., Ma, J. W., Lan, X. T., Zhao, Y., Tong, J., Li, G. Q., Shen, F. M., & Wang, P. (2021). NAD(+)-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5\/irisin. Theranostics, 11(9), 4381\u20134402. https:\/\/doi.org\/10.7150\/thno.53652","journal-title":"Theranostics"},{"key":"8666_CR49","doi-asserted-by":"publisher","first-page":"695","DOI":"10.2147\/NDT.S290148","volume":"17","author":"L Liu","year":"2021","unstructured":"Liu, L., Zhang, Q., Li, M., Wang, N., Li, C., Song, D., Shen, X., Luo, L., Fan, Y., Xie, H., & Wu, Y. (2021). Early post-stroke electroacupuncture promotes motor function recovery in post-ischemic rats by increasing the blood and brain irisin. Neuropsychiatric Disease and Treatment, 17, 695\u2013702. https:\/\/doi.org\/10.2147\/NDT.S290148","journal-title":"Neuropsychiatric Disease and Treatment"},{"issue":"1","key":"8666_CR50","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/s41591-018-0275-4","volume":"25","author":"MV Lourenco","year":"2019","unstructured":"Lourenco, M. V., Frozza, R. L., de Freitas, G. B., Zhang, H., Kincheski, G. C., Ribeiro, F. C., Goncalves, R. A., Clarke, J. R., Beckman, D., Staniszewski, A., Berman, H., Guerra, L. A., Forny-Germano, L., Meier, S., Wilcock, D. M., de Souza, J. M., Alves-Leon, S., Prado, V. F., Prado, M. A. M., \u2026 De Felice, F. G. (2019). Exercise-linked FNDC5\/irisin rescues synaptic plasticity and memory defects in Alzheimer\u2019s models. Nature Medicine, 25(1), 165\u2013175. https:\/\/doi.org\/10.1038\/s41591-018-0275-4","journal-title":"Nature Medicine"},{"issue":"8","key":"8666_CR51","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1053\/apmr.2002.33984","volume":"83","author":"NE Mayo","year":"2002","unstructured":"Mayo, N. E., Wood-Dauphinee, S., Cote, R., Durcan, L., & Carlton, J. (2002). Activity, participation, and quality of life 6 months poststroke. Archives of Physical Medicine and Rehabilitation, 83(8), 1035\u20131042. https:\/\/doi.org\/10.1053\/apmr.2002.33984","journal-title":"Archives of Physical Medicine and Rehabilitation"},{"issue":"4","key":"8666_CR52","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.maturitas.2011.01.014","volume":"68","author":"V Messier","year":"2011","unstructured":"Messier, V., Rabasa-Lhoret, R., Barbat-Artigas, S., Elisha, B., Karelis, A. D., & Aubertin-Leheudre, M. (2011). Menopause and sarcopenia: A potential role for sex hormones. Maturitas, 68(4), 331\u2013336. https:\/\/doi.org\/10.1016\/j.maturitas.2011.01.014","journal-title":"Maturitas"},{"issue":"8","key":"8666_CR53","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.metabol.2013.04.007","volume":"62","author":"HS Moon","year":"2013","unstructured":"Moon, H. S., Dincer, F., & Mantzoros, C. S. (2013). Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19\u20137 hippocampal cell lines. Metabolism, 62(8), 1131\u20131136. https:\/\/doi.org\/10.1016\/j.metabol.2013.04.007","journal-title":"Metabolism"},{"issue":"1","key":"8666_CR54","first-page":"81","volume":"52","author":"M Morreale","year":"2016","unstructured":"Morreale, M., Marchione, P., Pili, A., Lauta, A., Castiglia, S. F., Spallone, A., Pierelli, F., & Giacomini, P. (2016). Early versus delayed rehabilitation treatment in hemiplegic patients with ischemic stroke: Proprioceptive or cognitive approach? European Journal of Physical and Rehabilitation Medicine, 52(1), 81\u201389.","journal-title":"European Journal of Physical and Rehabilitation Medicine"},{"issue":"6","key":"8666_CR55","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1038\/jcbfm.2014.51","volume":"34","author":"KC Morris-Blanco","year":"2014","unstructured":"Morris-Blanco, K. C., Cohan, C. H., Neumann, J. T., Sick, T. J., & Perez-Pinzon, M. A. (2014). Protein kinase C epsilon regulates mitochondrial pools of Nampt and NAD following resveratrol and ischemic preconditioning in the rat cortex. Journal of Cerebral Blood Flow and Metabolism, 34(6), 1024\u20131032. https:\/\/doi.org\/10.1038\/jcbfm.2014.51","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"8666_CR56","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bmb\/ldq008","volume":"95","author":"MV Narici","year":"2010","unstructured":"Narici, M. V., & Maffulli, N. (2010). Sarcopenia: Characteristics, mechanisms and functional significance. British Medical Bulletin, 95, 139\u2013159. https:\/\/doi.org\/10.1093\/bmb\/ldq008","journal-title":"British Medical Bulletin"},{"key":"8666_CR57","doi-asserted-by":"publisher","first-page":"110840","DOI":"10.1016\/j.mce.2020.110840","volume":"510","author":"Y Nie","year":"2020","unstructured":"Nie, Y., Dai, B., Guo, X., & Liu, D. (2020). Cleavage of FNDC5 and insights into its maturation process. Molecular and Cellular Endocrinology, 510, 110840. https:\/\/doi.org\/10.1016\/j.mce.2020.110840","journal-title":"Molecular and Cellular Endocrinology"},{"issue":"18","key":"8666_CR58","doi-asserted-by":"publisher","first-page":"3167","DOI":"10.1042\/BCJ20170241","volume":"474","author":"Y Nie","year":"2017","unstructured":"Nie, Y., & Liu, D. (2017). N-Glycosylation is required for FDNC5 stabilization and irisin secretion. The Biochemical Journal, 474(18), 3167\u20133177. https:\/\/doi.org\/10.1042\/BCJ20170241","journal-title":"The Biochemical Journal"},{"issue":"8","key":"8666_CR59","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.05.001","volume":"28","author":"M Nozoe","year":"2019","unstructured":"Nozoe, M., Kanai, M., Kubo, H., Yamamoto, M., Shimada, S., & Mase, K. (2019). Prestroke sarcopenia and stroke severity in elderly patients with acute stroke. Journal of Stroke and Cerebrovascular Diseases, 28(8), 2228\u20132231. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2019.05.001","journal-title":"Journal of Stroke and Cerebrovascular Diseases"},{"key":"8666_CR60","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.3389\/fneur.2019.01255","volume":"10","author":"K Palmer","year":"2019","unstructured":"Palmer, K., Vetrano, D. L., Padua, L., Romano, V., Rivoiro, C., Scelfo, B., Marengoni, A., Bernabei, R., & Onder, G. (2019). Frailty syndromes in persons with cerebrovascular disease: A systematic review and meta-analysis. Frontiers in Neurology, 10, 1255. https:\/\/doi.org\/10.3389\/fneur.2019.01255","journal-title":"Frontiers in Neurology"},{"issue":"6","key":"8666_CR61","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/s0003-9993(00)90095-9","volume":"81","author":"S Paolucci","year":"2000","unstructured":"Paolucci, S., Antonucci, G., Grasso, M. G., Morelli, D., Troisi, E., Coiro, P., & Bragoni, M. (2000). Early versus delayed inpatient stroke rehabilitation: A matched comparison conducted in Italy. Archives of Physical Medicine and Rehabilitation, 81(6), 695\u2013700. https:\/\/doi.org\/10.1016\/s0003-9993(00)90095-9","journal-title":"Archives of Physical Medicine and Rehabilitation"},{"key":"8666_CR62","doi-asserted-by":"publisher","first-page":"5083634","DOI":"10.1155\/2018\/5083634","volume":"2018","author":"YJ Park","year":"2018","unstructured":"Park, Y. J., Park, S. W., & Lee, H. S. (2018). Comparison of the effectiveness of whole body vibration in stroke patients: A meta-analysis. BioMed Research International, 2018, 5083634. https:\/\/doi.org\/10.1155\/2018\/5083634","journal-title":"BioMed Research International"},{"key":"8666_CR63","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.molimm.2017.09.014","volume":"91","author":"J Peng","year":"2017","unstructured":"Peng, J., Deng, X., Huang, W., Yu, J. H., Wang, J. X., Wang, J. P., Yang, S. B., Liu, X., Wang, L., Zhang, Y., Zhou, X. Y., Yang, H., He, Y. Z., & Xu, F. Y. (2017). Irisin protects against neuronal injury induced by oxygen-glucose deprivation in part depends on the inhibition of ROS-NLRP3 inflammatory signaling pathway. Molecular Immunology, 91, 185\u2013194. https:\/\/doi.org\/10.1016\/j.molimm.2017.09.014","journal-title":"Molecular Immunology"},{"issue":"6","key":"8666_CR64","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/nrendo.2016.221","volume":"13","author":"N Perakakis","year":"2017","unstructured":"Perakakis, N., Triantafyllou, G. A., Fernandez-Real, J. M., Huh, J. Y., Park, K. H., Seufert, J., & Mantzoros, C. S. (2017). Physiology and role of irisin in glucose homeostasis. Nature Reviews Endocrinology, 13(6), 324\u2013337. https:\/\/doi.org\/10.1038\/nrendo.2016.221","journal-title":"Nature Reviews Endocrinology"},{"issue":"1","key":"8666_CR65","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1042\/cs0840095","volume":"84","author":"SK Phillips","year":"1993","unstructured":"Phillips, S. K., Rook, K. M., Siddle, N. C., Bruce, S. A., & Woledge, R. C. (1993). Muscle weakness in women occurs at an earlier age than in men, but strength is preserved by hormone replacement therapy. Clinical Science, 84(1), 95\u201398. https:\/\/doi.org\/10.1042\/cs0840095","journal-title":"Clinical Science"},{"issue":"5","key":"8666_CR66","doi-asserted-by":"publisher","first-page":"E512","DOI":"10.1152\/ajpendo.00308.2013","volume":"306","author":"MK Piya","year":"2014","unstructured":"Piya, M. K., Harte, A. L., Sivakumar, K., Tripathi, G., Voyias, P. D., James, S., Sabico, S., Al-Daghri, N. M., Saravanan, P., Barber, T. M., Kumar, S., Vatish, M., & McTernan, P. G. (2014). The identification of irisin in human cerebrospinal fluid: Influence of adiposity, metabolic markers, and gestational diabetes. American Journal of Physiology. Endocrinology and Metabolism, 306(5), E512-518. https:\/\/doi.org\/10.1152\/ajpendo.00308.2013","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"issue":"14","key":"8666_CR67","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1001\/jama.2015.3058","volume":"313","author":"S Prabhakaran","year":"2015","unstructured":"Prabhakaran, S., Ruff, I., & Bernstein, R. A. (2015). Acute stroke intervention: A systematic review. JAMA, 313(14), 1451\u20131462. https:\/\/doi.org\/10.1001\/jama.2015.3058","journal-title":"JAMA"},{"issue":"1","key":"8666_CR68","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s12905-020-01153-9","volume":"21","author":"N Rathnayake","year":"2021","unstructured":"Rathnayake, N., Alwis, G., Lenora, J., & Lekamwasam, S. (2021). Factors associated with measures of sarcopenia in pre and postmenopausal women. BMC Women\u2019s Health, 21(1), 5. https:\/\/doi.org\/10.1186\/s12905-020-01153-9","journal-title":"BMC Women's Health"},{"key":"8666_CR69","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092749","author":"AP Raval","year":"2018","unstructured":"Raval, A. P., Schatz, M., Bhattacharya, P., d\u2019Adesky, N., Rundek, T., Dietrich, W. D., & Bramlett, H. M. (2018). Whole body vibration therapy after ischemia reduces brain damage in reproductively senescent female rats. International Journal of Molecular Sciences. https:\/\/doi.org\/10.3390\/ijms19092749","journal-title":"International Journal of Molecular Sciences"},{"issue":"4","key":"8666_CR70","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.jsams.2008.02.002","volume":"12","author":"SS Rees","year":"2009","unstructured":"Rees, S. S., Murphy, A. J., & Watsford, M. L. (2009). Effects of whole body vibration on postural steadiness in an older population. Journal of Science and Medicine in Sport, 12(4), 440\u2013444. https:\/\/doi.org\/10.1016\/j.jsams.2008.02.002","journal-title":"Journal of Science and Medicine in Sport"},{"issue":"9","key":"8666_CR71","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1177\/0271678X16655551","volume":"36","author":"RG Rempe","year":"2016","unstructured":"Rempe, R. G., Hartz, A. M. S., & Bauer, B. (2016). Matrix metalloproteinases in the brain and blood-brain barrier: Versatile breakers and makers. Journal of Cerebral Blood Flow and Metabolism, 36(9), 1481\u20131507. https:\/\/doi.org\/10.1177\/0271678X16655551","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"issue":"4","key":"8666_CR72","doi-asserted-by":"publisher","first-page":"e60563","DOI":"10.1371\/journal.pone.0060563","volume":"8","author":"A Roca-Rivada","year":"2013","unstructured":"Roca-Rivada, A., Castelao, C., Senin, L. L., Landrove, M. O., Baltar, J., Belen Crujeiras, A., Seoane, L. M., Casanueva, F. F., & Pardo, M. (2013). FNDC5\/irisin is not only a myokine but also an adipokine. PLoS ONE, 8(4), e60563. https:\/\/doi.org\/10.1371\/journal.pone.0060563","journal-title":"PLoS ONE"},{"key":"8666_CR73","doi-asserted-by":"publisher","first-page":"100861","DOI":"10.1016\/j.yfrne.2020.100861","volume":"59","author":"M Schatz","year":"2020","unstructured":"Schatz, M., Saravanan, S., d\u2019Adesky, N. D., Bramlett, H., Perez-Pinzon, M. A., & Raval, A. P. (2020). Osteocalcin, ovarian senescence, and brain health. Frontiers in Neuroendocrinology, 59, 100861. https:\/\/doi.org\/10.1016\/j.yfrne.2020.100861","journal-title":"Frontiers in Neuroendocrinology"},{"issue":"1","key":"8666_CR74","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s13539-011-0024-8","volume":"2","author":"N Scherbakov","year":"2011","unstructured":"Scherbakov, N., & Doehner, W. (2011). Sarcopenia in stroke-facts and numbers on muscle loss accounting for disability after stroke. Journal of Cachexia, Sarcopenia and Muscle, 2(1), 5\u20138. https:\/\/doi.org\/10.1007\/s13539-011-0024-8","journal-title":"Journal of Cachexia, Sarcopenia and Muscle"},{"issue":"4","key":"8666_CR75","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.jamda.2014.12.007","volume":"16","author":"N Scherbakov","year":"2015","unstructured":"Scherbakov, N., Sandek, A., & Doehner, W. (2015). Stroke-related sarcopenia: Specific characteristics. Journal of the American Medical Directors Association, 16(4), 272\u2013276. https:\/\/doi.org\/10.1016\/j.jamda.2014.12.007","journal-title":"Journal of the American Medical Directors Association"},{"issue":"47","key":"8666_CR76","doi-asserted-by":"publisher","first-page":"33738","DOI":"10.1074\/jbc.M113.516641","volume":"288","author":"MA Schumacher","year":"2013","unstructured":"Schumacher, M. A., Chinnam, N., Ohashi, T., Shah, R. S., & Erickson, H. P. (2013). The structure of irisin reveals a novel intersubunit beta-sheet fibronectin type III (FNIII) dimer: Implications for receptor activation. Journal of Biological Chemistry, 288(47), 33738\u201333744. https:\/\/doi.org\/10.1074\/jbc.M113.516641","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"8666_CR77","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1172\/JCI44271","volume":"121","author":"P Seale","year":"2011","unstructured":"Seale, P., Conroe, H. M., Estall, J., Kajimura, S., Frontini, A., Ishibashi, J., Cohen, P., Cinti, S., & Spiegelman, B. M. (2011). Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. The Journal of Clinical Investigation, 121(1), 96\u2013105. https:\/\/doi.org\/10.1172\/JCI44271","journal-title":"The Journal of Clinical Investigation"},{"issue":"1","key":"8666_CR78","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.clnu.2016.12.002","volume":"37","author":"A Shiraishi","year":"2018","unstructured":"Shiraishi, A., Yoshimura, Y., Wakabayashi, H., & Tsuji, Y. (2018). Prevalence of stroke-related sarcopenia and its association with poor oral status in post-acute stroke patients: Implications for oral sarcopenia. Clinical Nutrition, 37(1), 204\u2013207. https:\/\/doi.org\/10.1016\/j.clnu.2016.12.002","journal-title":"Clinical Nutrition"},{"issue":"1","key":"8666_CR79","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1152\/japplphysiol.00129.2005","volume":"99","author":"KR Short","year":"2005","unstructured":"Short, K. R., Vittone, J. L., Bigelow, M. L., Proctor, D. N., Coenen-Schimke, J. M., Rys, P., & Nair, K. S. (2005). Changes in myosin heavy chain mRNA and protein expression in human skeletal muscle with age and endurance exercise training. Journal of Applied Physiology (1985), 99(1), 95\u2013102. https:\/\/doi.org\/10.1152\/japplphysiol.00129.2005","journal-title":"Journal of Applied Physiology (1985)"},{"issue":"9","key":"8666_CR80","doi-asserted-by":"publisher","first-page":"105092","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105092","volume":"29","author":"Y Su","year":"2020","unstructured":"Su, Y., Yuki, M., & Otsuki, M. (2020). Prevalence of stroke-related sarcopenia: A systematic review and meta-analysis. Journal of Stroke and Cerebrovascular Diseases, 29(9), 105092. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2020.105092","journal-title":"Journal of Stroke and Cerebrovascular Diseases"},{"issue":"9","key":"8666_CR81","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.metabol.2015.05.010","volume":"64","author":"Y Tsuchiya","year":"2015","unstructured":"Tsuchiya, Y., Ando, D., Takamatsu, K., & Goto, K. (2015). Resistance exercise induces a greater irisin response than endurance exercise. Metabolism, 64(9), 1042\u20131050. https:\/\/doi.org\/10.1016\/j.metabol.2015.05.010","journal-title":"Metabolism"},{"key":"8666_CR82","doi-asserted-by":"publisher","first-page":"640215","DOI":"10.3389\/fnagi.2021.640215","volume":"13","author":"T Tu","year":"2021","unstructured":"Tu, T., Yin, S., Pang, J., Zhang, X., Zhang, L., Zhang, Y., Xie, Y., Guo, K., Chen, L., Peng, J., & Jiang, Y. (2021). Irisin contributes to neuroprotection by promoting mitochondrial biogenesis after experimental subarachnoid hemorrhage. Frontiers in Aging Neuroscience, 13, 640215. https:\/\/doi.org\/10.3389\/fnagi.2021.640215","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"4","key":"8666_CR83","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1007\/s13311-018-0651-2","volume":"15","author":"WJ Tu","year":"2018","unstructured":"Tu, W. J., Qiu, H. C., Cao, J. L., Liu, Q., Zeng, X. W., & Zhao, J. Z. (2018). Decreased concentration of irisin is associated with poor functional outcome in ischemic stroke. Neurotherapeutics, 15(4), 1158\u20131167. https:\/\/doi.org\/10.1007\/s13311-018-0651-2","journal-title":"Neurotherapeutics"},{"key":"8666_CR84","doi-asserted-by":"publisher","first-page":"29898","DOI":"10.1038\/srep29898","volume":"6","author":"BM Varela-Rodriguez","year":"2016","unstructured":"Varela-Rodriguez, B. M., Pena-Bello, L., Juiz-Valina, P., Vidal-Bretal, B., Cordido, F., & Sangiao-Alvarellos, S. (2016). FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle. Science and Reports, 6, 29898. https:\/\/doi.org\/10.1038\/srep29898","journal-title":"Science and Reports"},{"key":"8666_CR100","doi-asserted-by":"publisher","unstructured":"Wang, K., Li, H., Wang, H., Wang, J. H., Song, F., & Sun, Y. (2018). Irisin exerts neuroprotective effects on cultured neurons by regulating astrocytes. Mediators of Inflammation, 2018, 9070341. https:\/\/doi.org\/10.1155\/2018\/9070341","DOI":"10.1155\/2018\/9070341"},{"issue":"1","key":"8666_CR85","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.bbrc.2016.04.047","volume":"474","author":"S Wang","year":"2016","unstructured":"Wang, S., & Pan, J. (2016). Irisin ameliorates depressive-like behaviors in rats by regulating energy metabolism. Biochemical and Biophysical Research Communications, 474(1), 22\u201328. https:\/\/doi.org\/10.1016\/j.bbrc.2016.04.047","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"8666_CR101","doi-asserted-by":"publisher","unstructured":"Wilkinson, S. B., Phillips, S. M., Atherton, P. J., Patel, R., Yarasheski, K. E., Tarnopolsky, M. A., & Rennie, M. J. (2008). Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle. Journal of Physiology, 586(15), 3701\u20133717. https:\/\/doi.org\/10.1113\/jphysiol.2008.153916","DOI":"10.1113\/jphysiol.2008.153916"},{"issue":"7","key":"8666_CR86","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1161\/STROKEAHA.117.016726","volume":"48","author":"DT Winovich","year":"2017","unstructured":"Winovich, D. T., Longstreth, W. T., Jr., Arnold, A. M., Varadhan, R., Zeki Al Hazzouri, A., Cushman, M., Newman, A. B., & Odden, M. C. (2017). Factors associated with ischemic stroke survival and recovery in older adults. Stroke, 48(7), 1818\u20131826. https:\/\/doi.org\/10.1161\/STROKEAHA.117.016726","journal-title":"Stroke"},{"issue":"1","key":"8666_CR87","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3233\/BPL-150019","volume":"1","author":"CD Wrann","year":"2015","unstructured":"Wrann, C. D. (2015). FNDC5\/irisin\u2014Their role in the nervous system and as a mediator for beneficial effects of exercise on the brain. Brain Plast, 1(1), 55\u201361. https:\/\/doi.org\/10.3233\/BPL-150019","journal-title":"Brain Plast"},{"issue":"5","key":"8666_CR88","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.cmet.2013.09.008","volume":"18","author":"CD Wrann","year":"2013","unstructured":"Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013). Exercise induces hippocampal BDNF through a PGC-1alpha\/FNDC5 pathway. Cell Metabolism, 18(5), 649\u2013659. https:\/\/doi.org\/10.1016\/j.cmet.2013.09.008","journal-title":"Cell Metabolism"},{"issue":"1","key":"8666_CR89","doi-asserted-by":"publisher","first-page":"387","DOI":"10.18632\/aging.102629","volume":"12","author":"J Wu","year":"2020","unstructured":"Wu, J., Dou, Y., Liu, W., Zhao, Y., & Liu, X. (2020). Osteocalcin improves outcome after acute ischemic stroke. Aging, 12(1), 387\u2013396. https:\/\/doi.org\/10.18632\/aging.102629","journal-title":"Aging"},{"issue":"1","key":"8666_CR90","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.pharmthera.2011.12.008","volume":"134","author":"X Wu","year":"2012","unstructured":"Wu, X., & Reddy, D. S. (2012). Integrins as receptor targets for neurological disorders. Pharmacology & Therapeutics, 134(1), 68\u201381. https:\/\/doi.org\/10.1016\/j.pharmthera.2011.12.008","journal-title":"Pharmacology & Therapeutics"},{"issue":"4","key":"8666_CR91","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/jcbfm.2013.242","volume":"34","author":"F Yang","year":"2014","unstructured":"Yang, F., Wang, Z., Wei, X., Han, H., Meng, X., Zhang, Y., Shi, W., Li, F., Xin, T., Pang, Q., & Yi, F. (2014). NLRP3 deficiency ameliorates neurovascular damage in experimental ischemic stroke. Journal of Cerebral Blood Flow and Metabolism, 34(4), 660\u2013667. https:\/\/doi.org\/10.1038\/jcbfm.2013.242","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"8666_CR92","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.redox.2018.03.002","volume":"16","author":"JL Yang","year":"2018","unstructured":"Yang, J. L., Mukda, S., & Chen, S. D. (2018). Diverse roles of mitochondria in ischemic stroke. Redox Biology, 16, 263\u2013275. https:\/\/doi.org\/10.1016\/j.redox.2018.03.002","journal-title":"Redox Biology"},{"issue":"2","key":"8666_CR93","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.pcad.2019.02.007","volume":"62","author":"MF Young","year":"2019","unstructured":"Young, M. F., Valaris, S., & Wrann, C. D. (2019). A role for FNDC5\/Irisin in the beneficial effects of exercise on the brain and in neurodegenerative diseases. Progress in Cardiovascular Diseases, 62(2), 172\u2013178. https:\/\/doi.org\/10.1016\/j.pcad.2019.02.007","journal-title":"Progress in Cardiovascular Diseases"},{"issue":"4","key":"8666_CR94","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1159\/000505961","volume":"49","author":"Q Yu","year":"2020","unstructured":"Yu, Q., Li, G., Ding, Q., Tao, L., Li, J., Sun, L., Sun, X., & Yang, Y. (2020). Irisin protects brain against ischemia\/reperfusion injury through suppressing TLR4\/MyD88 pathway. Cerebrovascular Diseases, 49(4), 346\u2013354. https:\/\/doi.org\/10.1159\/000505961","journal-title":"Cerebrovascular Diseases"},{"issue":"4","key":"8666_CR95","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1515\/bmc-2016-0012","volume":"7","author":"J Zhang","year":"2016","unstructured":"Zhang, J., & Zhang, W. (2016). Can irisin be a linker between physical activity and brain function? Biomolecular Concepts, 7(4), 253. https:\/\/doi.org\/10.1515\/bmc-2016-0012","journal-title":"Biomolecular Concepts"},{"key":"8666_CR96","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004031","author":"Y Zhang","year":"2016","unstructured":"Zhang, Y., Song, H., Zhang, Y., Wu, F., Mu, Q., Jiang, M., Wang, F., Zhang, W., Li, L., Shao, L., Li, S., Yang, L., Zhang, M., Wu, Q., & Tang, D. (2016). Irisin inhibits atherosclerosis by promoting endothelial proliferation through microRNA126\u20135p. Journal of the American Heart Association. https:\/\/doi.org\/10.1161\/JAHA.116.004031","journal-title":"Journal of the American Heart Association"},{"key":"8666_CR97","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3389\/fphys.2017.00171","volume":"8","author":"J Zhao","year":"2017","unstructured":"Zhao, J., Su, Z., Qu, C., & Dong, Y. (2017). Effects of 12 weeks resistance training on serum irisin in older male adults. Frontiers in Physiology, 8, 171. https:\/\/doi.org\/10.3389\/fphys.2017.00171","journal-title":"Frontiers in Physiology"}],"container-title":["NeuroMolecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-021-08666-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12017-021-08666-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-021-08666-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T11:52:19Z","timestamp":1652874739000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12017-021-08666-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,3]]},"references-count":99,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["8666"],"URL":"https:\/\/doi.org\/10.1007\/s12017-021-08666-y","relation":{},"ISSN":["1535-1084","1559-1174"],"issn-type":[{"value":"1535-1084","type":"print"},{"value":"1559-1174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,3]]},"assertion":[{"value":"15 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}