{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:19:15Z","timestamp":1793067555830,"version":"4.5.0"},"reference-count":127,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T00:00:00Z","timestamp":1747440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T00:00:00Z","timestamp":1747440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Private Universit\u00e4t Witten\/Herdecke gGmbH"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuromol Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alzheimer\u2019s disease (AD) remains one of the most debilitating neurodegenerative disorders, with its pathological hallmark being progressive cognitive decline and memory loss. Recent research has illuminated the crucial role of the brain-derived neurotrophic factor (BDNF) in the central nervous system (CNS), highlighting its impact on neurogenesis, synaptic plasticity, and neuronal survival. Dysregulation of the BDNF signaling axis, particularly the imbalance between its precursor form and mature BDNF, is strongly implicated in the pathophysiology of AD. This review explores the molecular mechanisms through which BDNF modulates AD neuropathology and presents novel therapeutic strategies to activate BDNF signaling. We focus on the potential of BDNF activators, such as TrkB agonists and mimetic molecules, to restore synaptic function and ameliorate cognitive deficits in AD. Furthermore, we examine the challenges in translating these findings into clinical practice, including issues with blood\u2013brain barrier penetration and the need for precise receptor targeting. The review emphasizes the therapeutic potential of repurposed drugs, including statins and metformin, in enhancing BDNF signaling and offers new insights into the future of AD treatment. Ultimately, this work provides a compelling argument for BDNF-based therapies as a promising avenue for mitigating the cognitive decline associated with Alzheimer\u2019s disease, signaling a hopeful direction for future research and clinical trials.<\/jats:p>","DOI":"10.1007\/s12017-025-08857-x","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T22:32:40Z","timestamp":1747434760000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Unlocking Alzheimer\u2019s Disease: The Role of BDNF Signaling in Neuropathology and Treatment"],"prefix":"10.1007","volume":"27","author":[{"given":"Saad Misfer","family":"Alqahtani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayder M.","family":"Al-kuraishy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali I.","family":"Al Gareeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali K.","family":"Albuhadily","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Alexiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios","family":"Papadakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loah R.","family":"Hemeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safaa A.","family":"Faheem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaber","family":"El-Saber Batiha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,17]]},"reference":[{"issue":"7","key":"8857_CR1","doi-asserted-by":"publisher","first-page":"3405","DOI":"10.1007\/s10571-023-01392-y","volume":"43","author":"FH AlAnazi","year":"2023","unstructured":"AlAnazi, F. H., Al-Kuraishy, H. M., Alexiou, A., Papadakis, M., Ashour, M. H. M., Alnaaim, S. A., Elhussieny, O., Saad, H. M., & Batiha, G.E.-S. (2023). Primary hypothyroidism and Alzheimer\u2019s disease: A tale of two. Cellular and Molecular Neurobiology, 43(7), 3405\u20133416.","journal-title":"Cellular and Molecular Neurobiology"},{"issue":"2","key":"8857_CR2","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s13760-023-02403-x","volume":"124","author":"NH Ali","year":"2024","unstructured":"Ali, N. H., Al-Kuraishy, H. M., Al-Gareeb, A. I., Alnaaim, S. A., Alexiou, A., Papadakis, M., Saad, H. M., & Batiha, G.E.-S. (2024a). The probable role of tissue plasminogen activator\/neuroserpin axis in Alzheimer\u2019s disease: A new perspective. Acta Neurologica Belgica, 124(2), 377\u2013388.","journal-title":"Acta Neurologica Belgica"},{"issue":"5","key":"8857_CR3","doi-asserted-by":"publisher","first-page":"2469","DOI":"10.1007\/s12035-023-03727-8","volume":"61","author":"NH Ali","year":"2024","unstructured":"Ali, N. H., Al-Kuraishy, H. M., Al-Gareeb, A. I., Alnaaim, S. A., Saad, H. M., & Batiha, G.E.-S. (2024b). The molecular pathway of p75 neurotrophin receptor (p75NTR) in Parkinson\u2019s disease: The way of new inroads. Molecular Neurobiology, 61(5), 2469\u20132480.","journal-title":"Molecular Neurobiology"},{"issue":"1","key":"8857_CR4","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s10571-024-01489-y","volume":"44","author":"NH Ali","year":"2024","unstructured":"Ali, N. H., Al-Kuraishy, H. M., Al-Gareeb, A. I., Hadi, N. R., Assiri, A. A., Alrouji, M., Welson, N. N., Alexiou, A., Papadakis, M., & Batiha, G.E.-S. (2024c). Hypoglycemia and Alzheimer disease risk: The possible role of dasiglucagon. Cellular and Molecular Neurobiology, 44(1), 55.","journal-title":"Cellular and Molecular Neurobiology"},{"issue":"2","key":"8857_CR5","doi-asserted-by":"publisher","first-page":"70","DOI":"10.4103\/bc.bc_42_19","volume":"6","author":"HM Al-Kuraishy","year":"2020","unstructured":"Al-Kuraishy, H. M., Abdulhadi, M. H., Hussien, N. R., Al-Niemi, M. S., Rasheed, H. A., & Al-Gareeb, A. I. (2020a). Involvement of orexinergic system in psychiatric and neurodegenerative disorders: A scoping review. Brain Circulation, 6(2), 70\u201380.","journal-title":"Brain Circulation"},{"issue":"1","key":"8857_CR6","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/s40001-022-00818-5","volume":"27","author":"HM Al-Kuraishy","year":"2022","unstructured":"Al-Kuraishy, H. M., Al-Fakhrany, O. M., Elekhnawy, E., Al-Gareeb, A. I., Alorabi, M., De Waard, M., Albogami, S. M., & Batiha, G.E.-S. (2022a). Traditional herbs against COVID-19: Back to old weapons to combat the new pandemic. European Journal of Medical Research, 27(1), 186.","journal-title":"European Journal of Medical Research"},{"issue":"1","key":"8857_CR7","doi-asserted-by":"publisher","first-page":"33","DOI":"10.4103\/japtr.JAPTR_330_18","volume":"10","author":"HM Al-Kuraishy","year":"2019","unstructured":"Al-Kuraishy, H. M., & Al-Gareeb, A. I. (2019). Effects of rosuvastatin on metabolic profile: Versatility of dose-dependent effect. Journal of Advanced Pharmaceutical Technology & Research, 10(1), 33\u201338.","journal-title":"Journal of Advanced Pharmaceutical Technology & Research"},{"key":"8857_CR8","doi-asserted-by":"publisher","DOI":"10.5812\/archcid.102624","author":"HM Al-Kuraishy","year":"2020","unstructured":"Al-Kuraishy, H. M., & Al-Gareeb, A. I. (2020). From SARS-CoV to nCoV-2019: Ruction and argument. Archives of Clinical Infectious Diseases. https:\/\/doi.org\/10.5812\/archcid.102624","journal-title":"Archives of Clinical Infectious Diseases"},{"issue":"2","key":"8857_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.1063","volume":"11","author":"HM Al-kuraishy","year":"2023","unstructured":"Al-kuraishy, H. M., Al-Gareeb, A. I., Alexiou, A., Papadakis, M., Alsayegh, A. A., Almohmadi, N. H., Saad, H. M., & Batiha, G. E. S. (2023). Pros and cons for statins use and risk of Parkinson\u2019s disease: An updated perspective. Pharmacology Research & Perspectives, 11(2), Article e01063.","journal-title":"Pharmacology Research & Perspectives"},{"issue":"12","key":"8857_CR10","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1111\/1753-0407.13334","volume":"14","author":"HM Al-kuraishy","year":"2022","unstructured":"Al-kuraishy, H. M., Al-Gareeb, A. I., Alexiou, A., Papadakis, M., Nadwa, E. H., Albogami, S. M., Alorabi, M., Saad, H. M., & Batiha, G. E. S. (2022). Metformin and growth differentiation factor 15 (GDF15) in type 2 diabetes mellitus: A hidden treasure. Journal of Diabetes, 14(12), 806\u2013814.","journal-title":"Journal of Diabetes"},{"issue":"10","key":"8857_CR11","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1089\/vim.2021.0042","volume":"34","author":"HM Al-Kuraishy","year":"2021","unstructured":"Al-Kuraishy, H. M., Al-Gareeb, A. I., Alkazmi, L., Alexiou, A., & Batiha, G.E.-S. (2021). Levamisole therapy in COVID-19. Viral Immunology, 34(10), 722\u2013725.","journal-title":"Viral Immunology"},{"issue":"1","key":"8857_CR12","doi-asserted-by":"publisher","first-page":"16","DOI":"10.4103\/ijpvm.IJPVM_567_18","volume":"11","author":"HM Al-Kuraishy","year":"2020","unstructured":"Al-Kuraishy, H. M., Al-Gareeb, A. I., & Al-Nami, M. S. (2020b). Irbesartan attenuates gentamicin-induced nephrotoxicity in rats through modulation of oxidative stress and endogenous antioxidant capacity. International Journal of Preventive Medicine, 11(1), 16.","journal-title":"International Journal of Preventive Medicine"},{"issue":"4","key":"8857_CR13","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1007\/s10753-022-01648-7","volume":"45","author":"HM Al-Kuraishy","year":"2022","unstructured":"Al-Kuraishy, H. M., Al-Gareeb, A. I., Al-Niemi, M. S., Aljowaie, R. M., Almutairi, S. M., Alexiou, A., & Batiha, G.E.-S. (2022b). The prospective effect of allopurinol on the oxidative stress index and endothelial dysfunction in Covid-19. Inflammation, 45(4), 1651\u20131667.","journal-title":"Inflammation"},{"key":"8857_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121532","volume":"320","author":"HM Al-Kuraishy","year":"2023","unstructured":"Al-Kuraishy, H. M., Al-Gareeb, A. I., Alsayegh, A. A., Abusudah, W. F., Almohmadi, N. H., Eldahshan, O. A., Ahmed, E. A., & Batiha, G.E.-S. (2023b). Insights on benzodiazepines\u2019 potential in Alzheimer\u2019s disease. Life Sciences, 320, Article 121532.","journal-title":"Life Sciences"},{"issue":"3","key":"8857_CR15","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s11064-022-03817-4","volume":"48","author":"HM Al-Kuraishy","year":"2023","unstructured":"Al-Kuraishy, H. M., Al-Gareeb, A. I., Alsayegh, A. A., Hakami, Z. H., Khamjan, N. A., Saad, H. M., Batiha, G.E.-S., & De Waard, M. (2023c). A potential link between visceral obesity and risk of Alzheimer\u2019s disease. Neurochemical Research, 48(3), 745\u2013766.","journal-title":"Neurochemical Research"},{"issue":"5","key":"8857_CR16","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1007\/s11010-022-04381-9","volume":"477","author":"HM Al-Kuraishy","year":"2022","unstructured":"Al-Kuraishy, H. M., Al-Gareeb, A. I., Butnariu, M., & Batiha, G.E.-S. (2022c). The crucial role of prolactin-lactogenic hormone in Covid-19. Molecular and Cellular Biochemistry, 477(5), 1381\u20131392.","journal-title":"Molecular and Cellular Biochemistry"},{"issue":"3","key":"8857_CR18","doi-asserted-by":"publisher","first-page":"239","DOI":"10.4103\/bbrj.bbrj_44_20","volume":"4","author":"HM Al-Kuraishy","year":"2020","unstructured":"Al-Kuraishy, H. M., Al-Gareeb, A. I., & Naji, M. T. (2020c). Brain natriuretic peptide in patients with acute ischemic stroke: Role of statins. Biomedical and Biotechnology Research Journal (BBRJ), 4(3), 239\u2013245.","journal-title":"Biomedical and Biotechnology Research Journal (BBRJ)"},{"issue":"3","key":"8857_CR19","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1007\/s10787-023-01163-7","volume":"31","author":"HM Al-Kuraishy","year":"2023","unstructured":"Al-Kuraishy, H. M., Al-Gareeb, A. I., Saad, H. M., & Batiha, G.E.-S. (2023d). Long-term use of metformin and Alzheimer\u2019s disease: Beneficial or detrimental effects. Inflammopharmacology, 31(3), 1107\u20131115.","journal-title":"Inflammopharmacology"},{"issue":"04","key":"8857_CR20","doi-asserted-by":"publisher","first-page":"317","DOI":"10.4103\/JLP.JLP_123_19","volume":"11","author":"HM Al-Kuraishy","year":"2019","unstructured":"Al-Kuraishy, H. M., Al-Gareeb, A. I., Shams, H. A., & Al-Mamorri, F. (2019). Endothelial dysfunction and inflammatory biomarkers as a response factor of concurrent coenzyme Q10 add-on metformin in patients with type 2 diabetes mellitus. Journal of Laboratory Physicians, 11(04), 317\u2013322.","journal-title":"Journal of Laboratory Physicians"},{"issue":"4","key":"8857_CR21","doi-asserted-by":"publisher","first-page":"496","DOI":"10.4103\/jnrp.jnrp_97_18","volume":"9","author":"HM Alkuraishy","year":"2018","unstructured":"Alkuraishy, H. M., Al-Gareeb, A. I., & Waheed, H. J. (2018). Lipoprotein-associated phospholipase A2 is linked with poor cardio-metabolic profile in patients with ischemic stroke: A study of effects of statins. Journal of Neurosciences in Rural Practice, 9(4), 496.","journal-title":"Journal of Neurosciences in Rural Practice"},{"key":"8857_CR22","doi-asserted-by":"publisher","first-page":"102233","DOI":"10.1016\/j.arr.2024.102233","volume":"95","author":"HM Al-Kuraishy","year":"2024","unstructured":"Al-Kuraishy, H. M., Jabir, M. S., Albuhadily, A. K., Al-Gareeb, A. I., Jawad, S. F., Swelum, A. A., & Hadi, N. R. (2024). Role of ketogenic diet in neurodegenerative diseases focusing on Alzheimer diseases: The guardian angle. Ageing Research Reviews, 95, 102233.","journal-title":"Ageing Research Reviews"},{"key":"8857_CR23","doi-asserted-by":"publisher","first-page":"102084","DOI":"10.1016\/j.arr.2023.102084","volume":"91","author":"HM Al-Kuraishy","year":"2023","unstructured":"Al-Kuraishy, H. M., Jabir, M. S., Albuhadily, A. K., Al-Gareeb, A. I., & Rafeeq, M. F. (2023f). The link between Alzheimer disease and metabolic syndrome: a mutual relationship and long rigorous investigation. Ageing Research Reviews, 91, 102084.","journal-title":"Ageing Research Reviews"},{"key":"8857_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.102119","author":"HM Al-Kuraishy","year":"2023","unstructured":"Al-Kuraishy, H. M., Jabir, M. S., Al-Gareeb, A. I., Albuhadily, A. K., Albukhaty, S., Sulaiman, G. M., & Batiha, G.E.-S. (2023e). Evaluation and targeting of amyloid precursor protein (APP)\/amyloid beta (A\u03b2) axis in amyloidogenic and non-amyloidogenic pathways: A time outside the tunnel. Ageing Research Reviews. https:\/\/doi.org\/10.1016\/j.arr.2023.102119","journal-title":"Ageing Research Reviews"},{"issue":"24","key":"8857_CR25","doi-asserted-by":"publisher","first-page":"3953","DOI":"10.1111\/jcmm.17965","volume":"27","author":"SA Alnaaim","year":"2023","unstructured":"Alnaaim, S. A., Al-kuraishy, H. M., Al-Gareeb, A. I., Ali, N. H., Alexiou, A., Papadakis, M., Saad, H. M., & Batiha, G. E. S. (2023). New insights on the potential anti-epileptic effect of metformin: Mechanistic pathway. Journal of Cellular and Molecular Medicine, 27(24), 3953\u20133965.","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"8857_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113225","volume":"152","author":"M Alorabi","year":"2022","unstructured":"Alorabi, M., Cavalu, S., Al-Kuraishy, H. M., Al-Gareeb, A. I., Mostafa-Hedeab, G., Negm, W. A., Youssef, A., El-Kadem, A. H., Saad, H. M., & Batiha, G.E.-S. (2022). Pentoxifylline and berberine mitigate diclofenac-induced acute nephrotoxicity in male rats via modulation of inflammation and oxidative stress. Biomedicine & Pharmacotherapy, 152, Article 113225.","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"1","key":"8857_CR27","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s13098-023-01082-1","volume":"15","author":"M Alrouji","year":"2023","unstructured":"Alrouji, M., Al-Kuraishy, H. M., Al-Gareeb, A. I., Alexiou, A., Papadakis, M., Saad, H. M., & Batiha, G.E.-S. (2023). The potential role of human islet amyloid polypeptide in type 2 diabetes mellitus and Alzheimer\u2019s diseases. Diabetology & Metabolic Syndrome, 15(1), 101.","journal-title":"Diabetology & Metabolic Syndrome"},{"issue":"4","key":"8857_CR28","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1007\/s11010-023-04771-7","volume":"479","author":"M Alrouji","year":"2024","unstructured":"Alrouji, M., Al-Kuraishy, H. M., Al-Gareeb, A. I., Ashour, N. A., Jabir, M. S., Negm, W. A., & Batiha, G.E.-S. (2024). Metformin role in Parkinson\u2019s disease: A double-sword effect. Molecular and Cellular Biochemistry, 479(4), 975\u2013991.","journal-title":"Molecular and Cellular Biochemistry"},{"issue":"10","key":"8857_CR29","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.3390\/brainsci12101290","volume":"12","author":"N Alsubaie","year":"2022","unstructured":"Alsubaie, N., Al-Kuraishy, H. M., Al-Gareeb, A. I., Alharbi, B., De Waard, M., Sabatier, J.-M., Saad, H. M., & Batiha, G.E.-S. (2022). Statins use in Alzheimer disease: Bane or boon from frantic search and narrative review. Brain Sciences, 12(10), 1290.","journal-title":"Brain Sciences"},{"issue":"8","key":"8857_CR30","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.3390\/biomedicines10082032","volume":"10","author":"AW Al-Thomali","year":"2022","unstructured":"Al-Thomali, A. W., Al-Kuraishy, H. M., Al-Gareeb, A. I., Al-buhadiliy, K. A., De Waard, M., Sabatier, J. M., Khan Khalil, A. A., Saad, H. M., & Batiha, G. E. S. (2022). Role of neuropilin 1 in COVID-19 patients with acute ischemic stroke. Biomedicines, 10(8), 2032.","journal-title":"Biomedicines"},{"issue":"2","key":"8857_CR31","doi-asserted-by":"publisher","first-page":"188429","DOI":"10.1016\/j.bbcan.2020.188429","volume":"1874","author":"M Al-Yozbaki","year":"2020","unstructured":"Al-Yozbaki, M., Acha-Sagredo, A., George, A., Liloglou, T., & Wilson, C. M. (2020). Balancing neurotrophin pathway and sortilin function: Its role in human disease. Biochimica Et Biophysica Acta (BBA)-Reviews on Cancer, 1874(2), 188429.","journal-title":"Biochimica Et Biophysica Acta (BBA)-Reviews on Cancer"},{"issue":"1","key":"8857_CR32","doi-asserted-by":"publisher","first-page":"17084","DOI":"10.1038\/s41598-022-20945-7","volume":"12","author":"O Ameen","year":"2022","unstructured":"Ameen, O., Samaka, R. M., & Abo-Elsoud, R. A. (2022). Metformin alleviates neurocognitive impairment in aging via activation of AMPK\/BDNF\/PI3K pathway. Scientific Reports, 12(1), 17084.","journal-title":"Scientific Reports"},{"key":"8857_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118020","volume":"257","author":"M Amidfar","year":"2020","unstructured":"Amidfar, M., de Oliveira, J., Kucharska, E., Budni, J., & Kim, Y.-K. (2020). The role of CREB and BDNF in neurobiology and treatment of Alzheimer\u2019s disease. Life Sciences, 257, Article 118020.","journal-title":"Life Sciences"},{"issue":"12","key":"8857_CR34","doi-asserted-by":"publisher","first-page":"6827","DOI":"10.3390\/ijms23126827","volume":"23","author":"KF Azman","year":"2022","unstructured":"Azman, K. F., & Zakaria, R. (2022a). Recent advances on the role of brain-derived neurotrophic factor (BDNF) in neurodegenerative diseases. International Journal of Molecular Sciences, 23(12), 6827.","journal-title":"International Journal of Molecular Sciences"},{"key":"8857_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126827","author":"KF Azman","year":"2022","unstructured":"Azman, K. F., & Zakaria, R. (2022b). Recent advances on the role of brain-derived neurotrophic factor (BDNF) in neurodegenerative diseases. International Journal of Molecular Sciences. https:\/\/doi.org\/10.3390\/ijms23126827","journal-title":"International Journal of Molecular Sciences"},{"key":"8857_CR36","doi-asserted-by":"publisher","first-page":"6661","DOI":"10.1007\/s12035-017-0866-y","volume":"55","author":"M Balietti","year":"2018","unstructured":"Balietti, M., Giuli, C., & Conti, F. (2018). Peripheral blood brain-derived neurotrophic factor as a biomarker of Alzheimer\u2019s disease: Are there methodological biases? Molecular Neurobiology, 55, 6661\u20136672.","journal-title":"Molecular Neurobiology"},{"issue":"2","key":"8857_CR37","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1515\/jbcpp-2021-0182","volume":"34","author":"M Banerjee","year":"2023","unstructured":"Banerjee, M., & Shenoy, R. R. (2023). Emphasizing roles of BDNF promoters and inducers in Alzheimer\u2019s disease for improving impaired cognition and memory. Journal of Basic and Clinical Physiology and Pharmacology, 34(2), 125\u2013136.","journal-title":"Journal of Basic and Clinical Physiology and Pharmacology"},{"key":"8857_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158417","author":"AH Bazzari","year":"2022","unstructured":"Bazzari, A. H., & Bazzari, F. H. (2022). BDNF therapeutic mechanisms in neuropsychiatric disorders. International Journal of Molecular Sciences. https:\/\/doi.org\/10.3390\/ijms23158417","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"8857_CR39","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1159\/000089137","volume":"21","author":"I Blasko","year":"2005","unstructured":"Blasko, I., Lederer, W., Oberbauer, H., Walch, T., Kemmler, G., Hinterhuber, H., Marksteiner, J., & Humpel, C. (2005). Measurement of thirteen biological markers in CSF of patients with Alzheimer\u2019s disease and other dementias. Dementia and Geriatric Cognitive Disorders, 21(1), 9\u201315.","journal-title":"Dementia and Geriatric Cognitive Disorders"},{"issue":"3","key":"8857_CR40","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/sj.bjp.0705638","volume":"141","author":"A Braun","year":"2004","unstructured":"Braun, A., Lommatzsch, M., Neuhaus-Steinmetz, U., Quarcoo, D., Glaab, T., McGregor, G. P., Fischer, A., & Renz, H. (2004). Brain-derived neurotrophic factor (BDNF) contributes to neuronal dysfunction in a model of allergic airway inflammation. British Journal of Pharmacology, 141(3), 431\u2013440. https:\/\/doi.org\/10.1038\/sj.bjp.0705638","journal-title":"British Journal of Pharmacology"},{"key":"8857_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.omtn.2022.05.037","volume":"29","author":"Q Cao","year":"2022","unstructured":"Cao, Q., Luo, S., Yao, W., Qu, Y., Wang, N., Hong, J., Murayama, S., Zhang, Z., Chen, J., & Hashimoto, K. (2022). Suppression of abnormal \u03b1-synuclein expression by activation of BDNF transcription ameliorates Parkinson\u2019s disease-like pathology. Molecular Therapy-Nucleic Acids, 29, 1\u201315.","journal-title":"Molecular Therapy-Nucleic Acids"},{"issue":"1","key":"8857_CR42","doi-asserted-by":"publisher","first-page":"e53596","DOI":"10.1371\/journal.pone.0053596","volume":"8","author":"MdC Cardenas-Aguayo","year":"2013","unstructured":"Cardenas-Aguayo, Md. C., Kazim, S. F., Grundke-Iqbal, I., & Iqbal, K. (2013). Neurogenic and neurotrophic effects of BDNF peptides in mouse hippocampal primary neuronal cell cultures. PLoS ONE, 8(1), e53596.","journal-title":"PLoS ONE"},{"issue":"3","key":"8857_CR43","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1073\/pnas.1718683115","volume":"115","author":"C Chen","year":"2018","unstructured":"Chen, C., Wang, Z., Zhang, Z., Liu, X., Kang, S. S., Zhang, Y., & Ye, K. (2018a). The prodrug of 7, 8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer\u2019s disease. Proceedings of the National Academy of Sciences, 115(3), 578\u2013583.","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"6","key":"8857_CR44","first-page":"496","volume":"34","author":"J-G Chen","year":"2018","unstructured":"Chen, J.-G., Jiang, Q.-C., Wen, B., Wang, R.-Y., Wu, Y.-G., & Li, X. (2018b). Effects of deoxygedunin on Alzheimer-like pathologic dysfunction induced by D-galactose combined with AlCl 3. Chinese Journal of Applied Physiology, 34(6), 496\u2013500.","journal-title":"Chinese Journal of Applied Physiology"},{"issue":"18","key":"8857_CR45","doi-asserted-by":"publisher","first-page":"7568","DOI":"10.18632\/aging.204306","volume":"14","author":"Y-J Chiu","year":"2022","unstructured":"Chiu, Y.-J., Lin, T.-H., Chang, K.-H., Lin, W., Hsieh-Li, H. M., Su, M.-T., Chen, C.-M., Sun, Y.-C., & Lee-Chen, G.-J. (2022). Novel TRKB agonists activate TRKB and downstream ERK and AKT signaling to protect A\u03b2-GFP SH-SY5Y cells against A\u03b2 toxicity. Aging (Albany NY), 14(18), 7568.","journal-title":"Aging (Albany NY)"},{"key":"8857_CR46","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.jpsychires.2024.01.001","volume":"170","author":"T Cui","year":"2024","unstructured":"Cui, T., Liu, Z., Li, Z., Han, Y., Xiong, W., Qu, Z., & Zhang, X. (2024). Serum brain-derived neurotrophic factor concentration is different between autism spectrum disorders and intellectual disability children and adolescents. Journal of Psychiatric Research, 170, 355\u2013360.","journal-title":"Journal of Psychiatric Research"},{"issue":"5","key":"8857_CR47","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1080\/01616412.2018.1447318","volume":"40","author":"X Cui","year":"2018","unstructured":"Cui, X., Fu, Z., Wang, M., Nan, X., & Zhang, B. (2018). Pitavastatin treatment induces neuroprotection through the BDNF-TrkB signalling pathway in cultured cerebral neurons after oxygen-glucose deprivation. Neurological Research, 40(5), 391\u2013397.","journal-title":"Neurological Research"},{"key":"8857_CR48","volume-title":"Exocytosis-dependent p75NTR signaling in neurodevelopment and its regulation by RELL1","author":"M Cumming","year":"2022","unstructured":"Cumming, M. (2022). Exocytosis-dependent p75NTR signaling in neurodevelopment and its regulation by RELL1. McGill University."},{"issue":"5","key":"8857_CR49","doi-asserted-by":"publisher","first-page":"e562","DOI":"10.1038\/tp.2015.55","volume":"5","author":"L Devi","year":"2015","unstructured":"Devi, L., & Ohno, M. (2015). TrkB reduction exacerbates Alzheimer\u2019s disease-like signaling aberrations and memory deficits without affecting \u03b2-amyloidosis in 5XFAD mice. Translational Psychiatry, 5(5), e562\u2013e562.","journal-title":"Translational Psychiatry"},{"key":"8857_CR50","first-page":"295","volume":"60","author":"DM Diniz","year":"2020","unstructured":"Diniz, D. M., Franze, S., & Homberg, J. R. (2020). Crossing the blood-brain-barrier: A bifunctional liposome for BDNF gene delivery\u2014a Pilot Study. bioRxiv, 60, 295.","journal-title":"bioRxiv"},{"key":"8857_CR51","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2022.924155","volume":"16","author":"S-H Dou","year":"2022","unstructured":"Dou, S.-H., Cui, Y., Huang, S.-M., & Zhang, B. (2022). The role of brain-derived neurotrophic factor signaling in central nervous system disease pathogenesis. Frontiers in Human Neuroscience, 16, Article 924155.","journal-title":"Frontiers in Human Neuroscience"},{"key":"8857_CR52","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s12031-018-1100-8","volume":"65","author":"Y Du","year":"2018","unstructured":"Du, Y., Wu, H.-T., Qin, X.-Y., Cao, C., Liu, Y., Cao, Z.-Z., & Cheng, Y. (2018). Postmortem brain, cerebrospinal fluid, and blood neurotrophic factor levels in Alzheimer\u2019s disease: A systematic review and meta-analysis. Journal of Molecular Neuroscience, 65, 289\u2013300.","journal-title":"Journal of Molecular Neuroscience"},{"issue":"34","key":"8857_CR53","doi-asserted-by":"publisher","first-page":"29556","DOI":"10.1074\/jbc.M111.219675","volume":"286","author":"SF Evans","year":"2011","unstructured":"Evans, S. F., Irmady, K., Ostrow, K., Kim, T., Nykjaer, A., Saftig, P., Blobel, C., & Hempstead, B. L. (2011). Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation. Journal of Biological Chemistry, 286(34), 29556\u201329567. https:\/\/doi.org\/10.1074\/jbc.M111.219675","journal-title":"Journal of Biological Chemistry"},{"key":"8857_CR54","doi-asserted-by":"publisher","first-page":"3173","DOI":"10.1007\/s00213-020-05602-z","volume":"237","author":"C-H Fan","year":"2020","unstructured":"Fan, C.-H., Lin, C.-W., Huang, H.-J., Lee-Chen, G.-J., Sun, Y.-C., Lin, W., Chen, C.-M., Chang, K.-H., Su, M.-T., & Hsieh-Li, H. M. (2020). LMDS-1, a potential TrkB receptor agonist provides a safe and neurotrophic effect for early-phase Alzheimer\u2019s disease. Psychopharmacology (Berl), 237, 3173\u20133190.","journal-title":"Psychopharmacology (Berl)"},{"key":"8857_CR55","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.jad.2019.09.013","volume":"260","author":"W Fang","year":"2020","unstructured":"Fang, W., Zhang, J., Hong, L., Huang, W., Dai, X., Ye, Q., & Chen, X. (2020). Metformin ameliorates stress-induced depression-like behaviors via enhancing the expression of BDNF by activating AMPK\/CREB-mediated histone acetylation. Journal of Affective Disorders, 260, 302\u2013313.","journal-title":"Journal of Affective Disorders"},{"key":"8857_CR56","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.jpsychires.2014.01.019","volume":"53","author":"MC Faria","year":"2014","unstructured":"Faria, M. C., Gon\u00e7alves, G. S., Rocha, N. P., Moraes, E. N., Bicalho, M. A., Cintra, M. T. G., de Paula, J. J., de Miranda, L. F. J. R., de Souza Ferreira, A. C., & Teixeira, A. L. (2014a). Increased plasma levels of BDNF and inflammatory markers in Alzheimer\u2019s disease. Journal of Psychiatric Research, 53, 166\u2013172.","journal-title":"Journal of Psychiatric Research"},{"key":"8857_CR57","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.jpsychires.2014.01.019","volume":"53","author":"MC Faria","year":"2014","unstructured":"Faria, M. C., Gon\u00e7alves, G. S., Rocha, N. P., Moraes, E. N., Bicalho, M. A., Gualberto Cintra, M. T., Jardim de Paula, J., Ravic, J., de Miranda, L. F., de Souza, C., Ferreira, A., Teixeira, A. L., Gomes, K. B., Carvalho, M., & Sousa, L. P. (2014b). Increased plasma levels of BDNF and inflammatory markers in Alzheimer\u2019s disease. Journal of Psychiatric Research, 53, 166\u2013172. https:\/\/doi.org\/10.1016\/j.jpsychires.2014.01.019","journal-title":"Journal of Psychiatric Research"},{"issue":"4","key":"8857_CR58","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.3233\/JAD-181240","volume":"68","author":"SA Farr","year":"2019","unstructured":"Farr, S. A., Roesler, E., Niehoff, M. L., Roby, D. A., McKee, A., & Morley, J. E. (2019). Metformin improves learning and memory in the SAMP8 mouse model of Alzheimer\u2019s disease. Journal of Alzheimer\u2019s Disease, 68(4), 1699\u20131710.","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"12","key":"8857_CR59","doi-asserted-by":"publisher","first-page":"8799","DOI":"10.1007\/s12035-018-1031-y","volume":"55","author":"H Ferrero","year":"2018","unstructured":"Ferrero, H., Larrayoz, I. M., Gil-Bea, F. J., Mart\u00ednez, A., & Ram\u00edrez, M. J. (2018). Adrenomedullin, a novel target for neurodegenerative diseases. Molecular Neurobiology, 55(12), 8799\u20138814.","journal-title":"Molecular Neurobiology"},{"issue":"4","key":"8857_CR60","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.bbadis.2017.01.023","volume":"1863","author":"G Gerenu","year":"2017","unstructured":"Gerenu, G., Martisova, E., Ferrero, H., Carracedo, M., Rantam\u00e4ki, T., Ramirez, M. J., & Gil-Bea, F. J. (2017). Modulation of BDNF cleavage by plasminogen-activator inhibitor-1 contributes to Alzheimer\u2019s neuropathology and cognitive deficits. Biochimica Et Biophysica Acta (BBA)-Molecular Basis of Disease, 1863(4), 991\u20131001.","journal-title":"Biochimica Et Biophysica Acta (BBA)-Molecular Basis of Disease"},{"issue":"1","key":"8857_CR61","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3233\/JAD-130497","volume":"37","author":"D Gezen-Ak","year":"2013","unstructured":"Gezen-Ak, D., Dursun, E., Hana\u011fas\u0131, H., Bilgi\u00e7, B., Lohman, E., Araz, \u00d6. S., Atasoy, \u0130L., Alayl\u0131o\u011flu, M., \u00d6nal, B., & G\u00fcrvit, H. (2013). BDNF, TNF\u03b1, HSP90, CFH, and IL-10 serum levels in patients with early or late onset Alzheimer\u2019s disease or mild cognitive impairment. Journal of Alzheimer\u2019s Disease, 37(1), 185\u2013195.","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"10","key":"8857_CR62","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.3109\/13880209.2016.1150306","volume":"54","author":"N Ghadernezhad","year":"2016","unstructured":"Ghadernezhad, N., Khalaj, L., Pazoki-Toroudi, H., Mirmasoumi, M., & Ashabi, G. (2016). Metformin pretreatment enhanced learning and memory in cerebral forebrain ischaemia: The role of the AMPK\/BDNF\/P70SK signalling pathway. Pharmaceutical Biology, 54(10), 2211\u20132219.","journal-title":"Pharmaceutical Biology"},{"issue":"6","key":"8857_CR63","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/j.neuropharm.2011.01.033","volume":"60","author":"A Gupta","year":"2011","unstructured":"Gupta, A., Bisht, B., & Dey, C. S. (2011). Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer\u2019s-like changes. Neuropharmacology, 60(6), 910\u2013920.","journal-title":"Neuropharmacology"},{"issue":"3","key":"8857_CR64","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.neulet.2010.09.007","volume":"487","author":"X Han","year":"2011","unstructured":"Han, X., Yang, N., Xu, Y., Zhu, J., Chen, Z., Liu, Z., Dang, G., & Song, C. (2011). Simvastatin treatment improves functional recovery after experimental spinal cord injury by upregulating the expression of BDNF and GDNF. Neuroscience Letters, 487(3), 255\u2013259.","journal-title":"Neuroscience Letters"},{"key":"8857_CR65","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.866343","volume":"9","author":"D Hasan Khudhair","year":"2022","unstructured":"Hasan Khudhair, D., Al-Gareeb, A. I., Al-Kuraishy, H. M., El-Kadem, A. H., Elekhnawy, E., Negm, W. A., Saber, S., Cavalu, S., Tirla, A., & Alotaibi, S. S. (2022). Combination of vitamin C and curcumin safeguards against methotrexate-induced acute liver injury in mice by synergistic antioxidant effects. Frontiers in Medicine, 9, Article 866343.","journal-title":"Frontiers in Medicine"},{"key":"8857_CR66","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1007\/s00415-020-10299-3","volume":"268","author":"Y Huang","year":"2021","unstructured":"Huang, Y., Huang, C., Zhang, Q., Wu, W., & Sun, J. (2021). Serum BDNF discriminates Parkinson\u2019s disease patients with depression from without depression and reflect motor severity and gender differences. Journal of Neurology, 268, 1411\u20131418.","journal-title":"Journal of Neurology"},{"issue":"7","key":"8857_CR67","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011528","volume":"5","author":"S-W Jang","year":"2010","unstructured":"Jang, S.-W., Liu, X., Chan, C. B., France, S. A., Sayeed, I., Tang, W., Lin, X., Xiao, G., Andero, R., & Chang, Q. (2010a). Deoxygedunin, a natural product with potent neurotrophic activity in mice. PLoS ONE, 5(7), Article e11528.","journal-title":"PLoS ONE"},{"issue":"8","key":"8857_CR68","doi-asserted-by":"publisher","first-page":"3876","DOI":"10.1073\/pnas.0912531107","volume":"107","author":"S-W Jang","year":"2010","unstructured":"Jang, S.-W., Liu, X., Pradoldej, S., Tosini, G., Chang, Q., Iuvone, P. M., & Ye, K. (2010b). N-acetylserotonin activates TrkB receptor in a circadian rhythm. Proceedings of the National Academy of Sciences, 107(8), 3876\u20133881.","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"9","key":"8857_CR69","doi-asserted-by":"publisher","first-page":"3107","DOI":"10.1093\/cercor\/bhu105","volume":"25","author":"A Jer\u00f3nimo-Santos","year":"2015","unstructured":"Jer\u00f3nimo-Santos, A., Vaz, S. H., Parreira, S., Rapaz-L\u00e9rias, S., Caetano, A. P., Bu\u00e9e-Scherrer, V., Castr\u00e9n, E., Valente, C. A., Blum, D., & Sebasti\u00e3o, A. M. (2015a). Dysregulation of TrkB receptors and BDNF function by amyloid-\u03b2 peptide is mediated by calpain. Cerebral Cortex, 25(9), 3107\u20133121.","journal-title":"Cerebral Cortex"},{"issue":"9","key":"8857_CR70","doi-asserted-by":"publisher","first-page":"3107","DOI":"10.1093\/cercor\/bhu105","volume":"25","author":"A Jer\u00f3nimo-Santos","year":"2015","unstructured":"Jer\u00f3nimo-Santos, A., Vaz, S. H., Parreira, S., Rapaz-L\u00e9rias, S., Caetano, A. P., Bu\u00e9e-Scherrer, V., Castr\u00e9n, E., Valente, C. A., Blum, D., Sebasti\u00e3o, A. M., & Di\u00f3genes, M. J. (2015b). Dysregulation of TrkB receptors and BDNF function by amyloid-\u03b2 peptide is mediated by calpain. Cerebral Cortex, 25(9), 3107\u20133121. https:\/\/doi.org\/10.1093\/cercor\/bhu105","journal-title":"Cerebral Cortex"},{"issue":"1","key":"8857_CR71","doi-asserted-by":"publisher","first-page":"257","DOI":"10.3390\/jcm9010257","volume":"9","author":"W Jin","year":"2020","unstructured":"Jin, W. (2020). Regulation of BDNF-TrkB signaling and potential therapeutic strategies for Parkinson\u2019s disease. Journal of Clinical Medicine, 9(1), 257.","journal-title":"Journal of Clinical Medicine"},{"key":"8857_CR72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13024-016-0119-y","volume":"11","author":"SF Kazim","year":"2016","unstructured":"Kazim, S. F., & Iqbal, K. (2016). Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: Emerging therapeutic modality for Alzheimer\u2019s disease. Molecular Neurodegeneration, 11, 1\u201316.","journal-title":"Molecular Neurodegeneration"},{"issue":"6","key":"8857_CR73","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1007\/s12035-021-02306-z","volume":"58","author":"J Keifer","year":"2021","unstructured":"Keifer, J. (2021). Comparative genomics of the BDNF gene, non-canonical modes of transcriptional regulation, and neurological disease. Molecular Neurobiology, 58(6), 2851\u20132861.","journal-title":"Molecular Neurobiology"},{"issue":"50","key":"8857_CR74","doi-asserted-by":"publisher","first-page":"21830","DOI":"10.1073\/pnas.0912793107","volume":"107","author":"E Kickstein","year":"2010","unstructured":"Kickstein, E., Krauss, S., Thornhill, P., Rutschow, D., Zeller, R., Sharkey, J., Williamson, R., Fuchs, M., K\u00f6hler, A., & Glossmann, H. (2010). Biguanide metformin acts on tau phosphorylation via mTOR\/protein phosphatase 2A (PP2A) signaling. Proceedings of the National Academy of Sciences, 107(50), 21830\u201321835.","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"8857_CR75","doi-asserted-by":"publisher","first-page":"7297","DOI":"10.1007\/s12035-016-0192-9","volume":"54","author":"BY Kim","year":"2017","unstructured":"Kim, B. Y., Lee, S. H., Graham, P. L., Angelucci, F., Lucia, A., Pareja-Galeano, H., Leyhe, T., Turana, Y., Lee, I. R., & Yoon, J. H. (2017). Peripheral brain-derived neurotrophic factor levels in Alzheimer\u2019s disease and mild cognitive impairment: A comprehensive systematic review and meta-analysis. Molecular Neurobiology, 54, 7297\u20137311.","journal-title":"Molecular Neurobiology"},{"key":"8857_CR76","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.136007","author":"PA Kipnis","year":"2020","unstructured":"Kipnis, P. A., Sullivan, B. J., Carter, B. M., & Kadam, S. D. (2020). TrkB agonists prevent postischemic emergence of refractory neonatal seizures in mice. JCI Insight. https:\/\/doi.org\/10.1172\/jci.insight.136007","journal-title":"JCI Insight"},{"key":"8857_CR77","doi-asserted-by":"publisher","DOI":"10.18103\/mra.v8i2.2043","author":"BM Kopec","year":"2020","unstructured":"Kopec, B. M., Zhao, L., Rosa-Molinar, E., & Siahaan, T. J. (2020). Non-invasive brain delivery and efficacy of BDNF in APP\/PS1 transgenic mice as a model of Alzheimer\u2019s disease. Medical Research Archives. https:\/\/doi.org\/10.18103\/mra.v8i2.2043","journal-title":"Medical Research Archives"},{"key":"8857_CR78","volume-title":"Role of BDNF and NGF in central nervous system myelination","author":"J Langhnoja","year":"2018","unstructured":"Langhnoja, J. (2018). Role of BDNF and NGF in central nervous system myelination. Maharaja Sayajirao University of Baroda."},{"issue":"5","key":"8857_CR79","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.jpsychires.2006.01.014","volume":"41","author":"C Laske","year":"2007","unstructured":"Laske, C., Stransky, E., Leyhe, T., Eschweiler, G. W., Maetzler, W., Wittorf, A., Soekadar, S., Richartz, E., Koehler, N., & Bartels, M. (2007). BDNF serum and CSF concentrations in Alzheimer\u2019s disease, normal pressure hydrocephalus and healthy controls. Journal of Psychiatric Research, 41(5), 387\u2013394.","journal-title":"Journal of Psychiatric Research"},{"issue":"15","key":"8857_CR80","doi-asserted-by":"publisher","first-page":"3359","DOI":"10.1016\/j.febslet.2010.06.025","volume":"584","author":"B Li","year":"2010","unstructured":"Li, B., Wanka, L., Blanchard, J., Liu, F., Chohan, M. O., Iqbal, K., & Grundke-Iqbal, I. (2010). Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice. FEBS Letters, 584(15), 3359\u20133365.","journal-title":"FEBS Letters"},{"issue":"11","key":"8857_CR81","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1038\/mp.2014.123","volume":"20","author":"YY Lim","year":"2015","unstructured":"Lim, Y. Y., Villemagne, V. L., Laws, S. M., Pietrzak, R., Snyder, P., Ames, D., Ellis, K. A., Harrington, K., Rembach, A., & Martins, R. N. (2015). APOE and BDNF polymorphisms moderate amyloid \u03b2-related cognitive decline in preclinical Alzheimer\u2019s disease. Molecular Psychiatry, 20(11), 1322\u20131328.","journal-title":"Molecular Psychiatry"},{"issue":"5","key":"8857_CR82","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1007\/s12035-018-1283-6","volume":"56","author":"B Lima Giacobbo","year":"2019","unstructured":"Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R., Bromberg, E., & de Vries, E. F. J. (2019). Brain-derived neurotrophic factor in brain disorders: Focus on neuroinflammation. Molecular Neurobiology, 56(5), 3295\u20133312. https:\/\/doi.org\/10.1007\/s12035-018-1283-6","journal-title":"Molecular Neurobiology"},{"issue":"8","key":"8857_CR83","doi-asserted-by":"publisher","first-page":"2869","DOI":"10.1093\/brain\/awac093","volume":"145","author":"CP Lin","year":"2022","unstructured":"Lin, C. P., Frigerio, I., Boon, B. D., Zhou, Z., Rozemuller, A. J., Bouwman, F. H., Schoonheim, M. M., van de Berg, W. D., & Jonkman, L. E. (2022). Structural (dys) connectivity associates with cholinergic cell density in Alzheimer\u2019s disease. Brain, 145(8), 2869\u20132881.","journal-title":"Brain"},{"issue":"23","key":"8857_CR84","doi-asserted-by":"publisher","first-page":"8274","DOI":"10.1021\/jm101206p","volume":"53","author":"X Liu","year":"2010","unstructured":"Liu, X., Chan, C.-B., Jang, S.-W., Pradoldej, S., Huang, J., He, K., Phun, L. H., France, S., Xiao, G., & Jia, Y. (2010). A synthetic 7, 8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. Journal of Medicinal Chemistry, 53(23), 8274\u20138286.","journal-title":"Journal of Medicinal Chemistry"},{"issue":"7","key":"8857_CR85","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/nrd4024","volume":"12","author":"FM Longo","year":"2013","unstructured":"Longo, F. M., & Massa, S. M. (2013). Small-molecule modulation of neurotrophin receptors: A strategy for the treatment of neurological disease. Nature Reviews Drug Discovery, 12(7), 507\u2013525.","journal-title":"Nature Reviews Drug Discovery"},{"issue":"5","key":"8857_CR86","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1172\/JCI41356","volume":"120","author":"SM Massa","year":"2010","unstructured":"Massa, S. M., Yang, T., Xie, Y., Shi, J., Bilgen, M., Joyce, J. N., Nehama, D., Rajadas, J., & Longo, F. M. (2010). Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. The Journal of Clinical Investigation, 120(5), 1774\u20131785.","journal-title":"The Journal of Clinical Investigation"},{"key":"8857_CR87","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2023.107200","volume":"195","author":"A McGonigal","year":"2023","unstructured":"McGonigal, A., Becker, C., Fath, J., Hammam, K., Baumstarck, K., Fernandes, S., Giusiano, B., Dufau, S., Rheims, S., Maillard, L., Biraben, A., Benoliel, J. J., Bernard, C., & Bartolomei, F. (2023). BDNF as potential biomarker of epilepsy severity and psychiatric comorbidity: Pitfalls in the clinical population. Epilepsy Research, 195, Article 107200. https:\/\/doi.org\/10.1016\/j.eplepsyres.2023.107200","journal-title":"Epilepsy Research"},{"issue":"5","key":"8857_CR88","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1172\/JCI79300","volume":"125","author":"DP Meka","year":"2015","unstructured":"Meka, D. P., M\u00fcller-Rischart, A. K., Nidadavolu, P., Mohammadi, B., Motori, E., Ponna, S. K., Aboutalebi, H., Bassal, M., Annamneedi, A., & Finckh, B. (2015). Parkin cooperates with GDNF\/RET signaling to prevent dopaminergic neuron degeneration. The Journal of Clinical Investigation, 125(5), 1873\u20131885.","journal-title":"The Journal of Clinical Investigation"},{"issue":"6","key":"8857_CR89","doi-asserted-by":"publisher","first-page":"925","DOI":"10.33549\/physiolres.932996","volume":"64","author":"PN Menshanov","year":"2015","unstructured":"Menshanov, P. N., Lanshakov, D. A., & Dygalo, N. N. (2015). proBDNF is a major product of bdnf gene expressed in the perinatal rat cortex. Physiological Research, 64(6), 925\u2013934. https:\/\/doi.org\/10.33549\/physiolres.932996","journal-title":"Physiological Research"},{"key":"8857_CR90","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105281","volume":"162","author":"C Miranda-Louren\u00e7o","year":"2020","unstructured":"Miranda-Louren\u00e7o, C., Ribeiro-Rodrigues, L., Fonseca-Gomes, J., Tanqueiro, S. R., Belo, R. F., Ferreira, C. B., Rei, N., Ferreira-Manso, M., de Almeida-Borlido, C., & Costa-Coelho, T. (2020). Challenges of BDNF-based therapies: From common to rare diseases. Pharmacological Research, 162, Article 105281.","journal-title":"Pharmacological Research"},{"key":"8857_CR91","doi-asserted-by":"publisher","first-page":"109571","DOI":"10.1016\/j.intimp.2022.109571","volume":"114","author":"YT Mohamed","year":"2023","unstructured":"Mohamed, Y. T., Salama, A., Rabie, M. A., & Abd El Fattah, M. A. (2023). Neuroprotective effect of secukinumab against rotenone induced Parkinson\u2019s disease in rat model: Involvement of IL-17, HMGB-1\/TLR4 axis and BDNF\/TrKB cascade. International Immunopharmacology, 114, 109571.","journal-title":"International Immunopharmacology"},{"issue":"5","key":"8857_CR92","doi-asserted-by":"publisher","first-page":"285","DOI":"10.3390\/brainsci10050285","volume":"10","author":"C Molinari","year":"2020","unstructured":"Molinari, C., Morsanuto, V., Ruga, S., Notte, F., Farghali, M., Galla, R., & Uberti, F. (2020). The role of BDNF on aging-modulation markers. Brain Sciences, 10(5), 285.","journal-title":"Brain Sciences"},{"issue":"3","key":"8857_CR93","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1007\/s10787-022-00993-1","volume":"30","author":"G Mostafa-Hedeab","year":"2022","unstructured":"Mostafa-Hedeab, G., Al-Kuraishy, H. M., Al-Gareeb, A. I., Jeandet, P., Saad, H. M., & Batiha, G.E.-S. (2022). A raising dawn of pentoxifylline in management of inflammatory disorders in Covid-19. Inflammopharmacology, 30(3), 799\u2013809.","journal-title":"Inflammopharmacology"},{"issue":"14","key":"8857_CR94","doi-asserted-by":"publisher","first-page":"7553","DOI":"10.3390\/ijerph18147553","volume":"18","author":"E Murawska-Cia\u0142owicz","year":"2021","unstructured":"Murawska-Cia\u0142owicz, E., Wiatr, M., Cia\u0142owicz, M., Gomes de Assis, G., Borowicz, W., Rocha-Rodrigues, S., Paprocka-Borowicz, M., & Marques, A. (2021). BDNF impact on biological markers of depression\u2014role of physical exercise and training. International Journal of Environmental Research and Public Health, 18(14), 7553.","journal-title":"International Journal of Environmental Research and Public Health"},{"issue":"3","key":"8857_CR95","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/nm.1912","volume":"15","author":"AH Nagahara","year":"2009","unstructured":"Nagahara, A. H., Merrill, D. A., Coppola, G., Tsukada, S., Schroeder, B. E., Shaked, G. M., Wang, L., Blesch, A., Kim, A., & Conner, J. M. (2009). Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer\u2019s disease. Nature Medicine, 15(3), 331\u2013337.","journal-title":"Nature Medicine"},{"key":"8857_CR96","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-021-06968-9","author":"A Nasrolahi","year":"2022","unstructured":"Nasrolahi, A., Javaherforooshzadeh, F., Jafarzadeh-Gharehziaaddin, M., Mahmoudi, J., Asl, K. D., & Shabani, Z. (2022). Therapeutic potential of neurotrophic factors in Alzheimer\u2019s disease. Molecular Biology Reports. https:\/\/doi.org\/10.1007\/s11033-021-06968-9","journal-title":"Molecular Biology Reports"},{"issue":"2","key":"8857_CR97","doi-asserted-by":"publisher","first-page":"257","DOI":"10.3390\/ijms20020257","volume":"20","author":"TKS Ng","year":"2019","unstructured":"Ng, T. K. S., Ho, C. S. H., Tam, W. W. S., Kua, E. H., & Ho, R.C.-M. (2019). Decreased serum brain-derived neurotrophic factor (BDNF) levels in patients with Alzheimer\u2019s disease (AD): A systematic review and meta-analysis. International Journal of Molecular Sciences, 20(2), 257.","journal-title":"International Journal of Molecular Sciences"},{"issue":"11","key":"8857_CR98","doi-asserted-by":"publisher","first-page":"5719","DOI":"10.3390\/ijms22115719","volume":"22","author":"T Numakawa","year":"2021","unstructured":"Numakawa, T., & Odaka, H. (2021). Brain-derived neurotrophic factor signaling in the pathophysiology of Alzheimer\u2019s disease: Beneficial effects of flavonoids for neuroprotection. International Journal of Molecular Sciences, 22(11), 5719.","journal-title":"International Journal of Molecular Sciences"},{"issue":"2","key":"8857_CR99","doi-asserted-by":"publisher","first-page":"11084","DOI":"10.55779\/nsb14211084","volume":"14","author":"UM Okezie","year":"2022","unstructured":"Okezie, U. M., Okoye, F. B., & Esimone, C. O. (2022). Orthosporin, a major component of the fermentation product of Lasiodiplodia theobromae-an endophytic fungus of Musa paradisiaca as a potential antimicrobial agent. Notulae Scientia Biologicae, 14(2), 11084\u201311084.","journal-title":"Notulae Scientia Biologicae"},{"issue":"5","key":"8857_CR100","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1093\/eurjpc\/zwab208","volume":"29","author":"E Olmastroni","year":"2022","unstructured":"Olmastroni, E., Molari, G., De Beni, N., Colpani, O., Galimberti, F., Gazzotti, M., Zambon, A., Catapano, A. L., & Casula, M. (2022). Statin use and risk of dementia or Alzheimer\u2019s disease: A systematic review and meta-analysis of observational studies. European Journal of Preventive Cardiology, 29(5), 804\u2013814.","journal-title":"European Journal of Preventive Cardiology"},{"issue":"2","key":"8857_CR101","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/jnc.15683","volume":"163","author":"C Orciani","year":"2022","unstructured":"Orciani, C., Hall, H., Pentz, R., Foret, M. K., Do Carmo, S., & Cuello, A. C. (2022). Long-term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and BDNF levels without affecting the NGF synthesis. Journal of Neurochemistry, 163(2), 149\u2013167.","journal-title":"Journal of Neurochemistry"},{"key":"8857_CR102","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.jconrel.2021.01.027","volume":"331","author":"S Padmakumar","year":"2021","unstructured":"Padmakumar, S., Jones, G., Pawar, G., Khorkova, O., Hsiao, J., Kim, J., Amiji, M. M., & Bleier, B. S. (2021). Minimally Invasive Nasal Depot (MIND) technique for direct BDNF AntagoNAT delivery to the brain. Journal of Controlled Release, 331, 176\u2013186. https:\/\/doi.org\/10.1016\/j.jconrel.2021.01.027","journal-title":"Journal of Controlled Release"},{"key":"8857_CR103","doi-asserted-by":"publisher","DOI":"10.3390\/ph14080704","author":"P Pankiewicz","year":"2021","unstructured":"Pankiewicz, P., Szybi\u0144ski, M., Kisielewska, K., Go\u0142\u0119biowski, F., Krzemi\u0144ski, P., Rutkowska-W\u0142odarczyk, I., Moszczy\u0144ski-P\u0119tkowski, R., Gurba-Bry\u015bkiewicz, L., Delis, M., Mulewski, K., Smuga, D., Dominowski, J., Janusz, A., G\u00f3rka, M., Abramski, K., Napi\u00f3rkowska, A., Nowotny, M., Dubiel, K., Kalita, K., \u2026 Mat\u0142oka, M. (2021). Do small molecules activate the TrkB receptor in the same manner as BDNF? Limitations of published TrkB low molecular agonists and screening for novel TrkB orthosteric agonists. Pharmaceuticals (Basel). https:\/\/doi.org\/10.3390\/ph14080704","journal-title":"Pharmaceuticals (Basel)"},{"issue":"6","key":"8857_CR104","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1111\/j.1471-4159.2005.03135.x","volume":"93","author":"S Peng","year":"2005","unstructured":"Peng, S., Wuu, J., Mufson, E. J., & Fahnestock, M. (2005). Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer\u2019s disease. Journal of Neurochemistry, 93(6), 1412\u20131421.","journal-title":"Journal of Neurochemistry"},{"key":"8857_CR105","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02367-7","author":"M Pettorruso","year":"2024","unstructured":"Pettorruso, M., Miuli, A., Clemente, K., Mancusi, G., Migliara, G., Di Carlo, F., Pernaci, G., Di Crosta, T., Santorelli, M., & d\u2019Andrea, G. (2024). Enhanced peripheral levels of BDNF and proBDNF: Elucidating neurotrophin dynamics in cocaine use disorder. Molecular Psychiatry. https:\/\/doi.org\/10.1038\/s41380-023-02367-7","journal-title":"Molecular Psychiatry"},{"issue":"4","key":"8857_CR106","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062241","volume":"8","author":"S Pilakka-Kanthikeel","year":"2013","unstructured":"Pilakka-Kanthikeel, S., Atluri, V. S., Sagar, V., Saxena, S. K., & Nair, M. (2013). Targeted brain derived neurotropic factors (BDNF) delivery across the blood-brain barrier for neuro-protection using magnetic nano carriers: An in-vitro study. PLoS ONE, 8(4), Article e62241. https:\/\/doi.org\/10.1371\/journal.pone.0062241","journal-title":"PLoS ONE"},{"key":"8857_CR107","doi-asserted-by":"publisher","first-page":"368","DOI":"10.3389\/fncel.2019.00368","volume":"13","author":"J Pradhan","year":"2019","unstructured":"Pradhan, J., Noakes, P. G., & Bellingham, M. C. (2019). The role of altered BDNF\/TrkB signaling in amyotrophic lateral sclerosis. Frontiers in Cellular Neuroscience, 13, 368.","journal-title":"Frontiers in Cellular Neuroscience"},{"issue":"2","key":"8857_CR108","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/mp.2016.62","volume":"22","author":"X Qin","year":"2017","unstructured":"Qin, X., Cao, C., Cawley, N., Liu, T., Yuan, J., Loh, Y., & Cheng, Y. (2017). Decreased peripheral brain-derived neurotrophic factor levels in Alzheimer\u2019s disease: A meta-analysis study (N\u00a0= 7277). Molecular Psychiatry, 22(2), 312\u2013320.","journal-title":"Molecular Psychiatry"},{"issue":"16","key":"8857_CR109","doi-asserted-by":"publisher","first-page":"8814","DOI":"10.3390\/ijms22168814","volume":"22","author":"D Ribeiro","year":"2021","unstructured":"Ribeiro, D., Petrigna, L., Pereira, F. C., Muscella, A., Bianco, A., & Tavares, P. (2021). The impact of physical exercise on the circulating levels of BDNF and NT 4\/5: A review. International Journal of Molecular Sciences, 22(16), 8814.","journal-title":"International Journal of Molecular Sciences"},{"issue":"9","key":"8857_CR110","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1038\/s41593-024-01730-3","volume":"27","author":"AO Sasmita","year":"2024","unstructured":"Sasmita, A. O., Depp, C., Nazarenko, T., Sun, T., Siems, S. B., Ong, E. C., Nkeh, Y. B., B\u00f6hler, C., Xuan, Yu., Bues, B., Evangelista, L., Mao, S., Morgado, B., Zoe, Wu., Ruhwedel, T., Subramanian, S., B\u00f6rensen, F., Overhoff, K., Spieth, L., \u2026 Nave, K.-A. (2024). Oligodendrocytes produce amyloid-\u03b2 and contribute to plaque formation alongside neurons in Alzheimer\u2019s disease model mice. Nature Neuroscience, 27(9), 1668\u20131674. https:\/\/doi.org\/10.1038\/s41593-024-01730-3","journal-title":"Nature Neuroscience"},{"key":"8857_CR111","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.euroneuro.2020.01.015","volume":"33","author":"E Schueller","year":"2020","unstructured":"Schueller, E., Paiva, I., Blanc, F., Wang, X.-L., Cassel, J.-C., Boutillier, A.-L., & Bousiges, O. (2020). Dysregulation of histone acetylation pathways in hippocampus and frontal cortex of Alzheimer\u2019s disease patients. European Neuropsychopharmacology, 33, 101\u2013116.","journal-title":"European Neuropsychopharmacology"},{"issue":"19","key":"8857_CR112","doi-asserted-by":"publisher","first-page":"7538","DOI":"10.1523\/JNEUROSCI.0260-15.2015","volume":"35","author":"A Sen","year":"2015","unstructured":"Sen, A., Nelson, T. J., & Alkon, D. L. (2015). ApoE4 and A\u03b2 oligomers reduce BDNF expression via HDAC nuclear translocation. Journal of Neuroscience, 35(19), 7538\u20137551.","journal-title":"Journal of Neuroscience"},{"key":"8857_CR113","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3389\/fnagi.2014.00069","volume":"6","author":"H Shimada","year":"2014","unstructured":"Shimada, H., Makizako, H., Doi, T., Yoshida, D., Tsutsumimoto, K., Anan, Y., Uemura, K., Lee, S., Park, H., & Suzuki, T. (2014). A large, cross-sectional observational study of serum BDNF, cognitive function, and mild cognitive impairment in the elderly. Frontiers in Aging Neuroscience, 6, 69.","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"17","key":"8857_CR114","doi-asserted-by":"publisher","first-page":"5163","DOI":"10.3390\/molecules26175163","volume":"26","author":"RK Sindhu","year":"2021","unstructured":"Sindhu, R. K., Verma, R., Salgotra, T., Rahman, M. H., Shah, M., Akter, R., Murad, W., Mubin, S., Bibi, P., & Qusti, S. (2021). Impacting the remedial potential of nano delivery-based flavonoids for breast cancer treatment. Molecules, 26(17), 5163.","journal-title":"Molecules"},{"key":"8857_CR115","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.678182","volume":"9","author":"W Sun","year":"2021","unstructured":"Sun, W., Cheng, H., Yang, Y., Tang, D., Li, X., & An, L. (2021). Requirements of postnatal proBDNF in the hippocampus for spatial memory consolidation and neural function. Front Cell Dev Biol, 9, Article 678182. https:\/\/doi.org\/10.3389\/fcell.2021.678182","journal-title":"Front Cell Dev Biol"},{"key":"8857_CR116","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.945348","volume":"15","author":"C Tacke","year":"2022","unstructured":"Tacke, C., DiStefano, P. S., Lindsay, R. M., Metzdorf, K., Zagrebelsky, M., & Korte, M. (2022). Actions of the TrkB agonist antibody ZEB85 in regulating the architecture and synaptic plasticity in hippocampal neurons. Frontiers in Molecular Neuroscience, 15, Article 945348.","journal-title":"Frontiers in Molecular Neuroscience"},{"issue":"6","key":"8857_CR117","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1016\/j.mehy.2006.09.043","volume":"68","author":"S-J Tsai","year":"2007","unstructured":"Tsai, S.-J. (2007). Statins may enhance the proteolytic cleavage of proBDNF: Implications for the treatment of depression. Medical Hypotheses, 68(6), 1296\u20131299.","journal-title":"Medical Hypotheses"},{"issue":"3","key":"8857_CR118","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1080\/01616412.2022.2129760","volume":"45","author":"T Wang","year":"2023","unstructured":"Wang, T., Li, T., Hao, S., Han, Y., & Cai, Y. (2023). Association of plasma BDNF levels with different stages of Alzheimer\u2019s disease: A cross-sectional study. Neurological Research, 45(3), 234\u2013240.","journal-title":"Neurological Research"},{"issue":"3","key":"8857_CR119","doi-asserted-by":"publisher","first-page":"191","DOI":"10.5603\/MRJ.a2020.0019","volume":"5","author":"A We\u0142niak","year":"2020","unstructured":"We\u0142niak, A., Koszykowska, P., & K\u0119dziora-Kornatowska, K. (2020). Statins and Alzheimer\u2014current stand and further development directions. Medical Research Journal, 5(3), 191\u2013200.","journal-title":"Medical Research Journal"},{"key":"8857_CR120","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113812","volume":"345","author":"P Yan","year":"2021","unstructured":"Yan, P., Xue, Z., Li, D., Ni, S., Wang, C., Jin, X., Zhou, D., Li, X., Zhao, X., & Chen, X. (2021). Dysregulated CRTC1-BDNF signaling pathway in the hippocampus contributes to A\u03b2 oligomer-induced long-term synaptic plasticity and memory impairment. Experimental Neurology, 345, Article 113812.","journal-title":"Experimental Neurology"},{"issue":"3","key":"8857_CR121","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101558R","volume":"36","author":"CR Yang","year":"2022","unstructured":"Yang, C. R., Ding, H. J., Yu, M., Zhou, F. H., Han, C. Y., Liang, R., Zhang, X. Y., Zhang, X. L., Meng, F. J., & Wang, S. (2022). proBDNF\/p75NTR promotes rheumatoid arthritis and inflammatory response by activating proinflammatory cytokines. The FASEB Journal, 36(3), Article e22180.","journal-title":"The FASEB Journal"},{"key":"8857_CR122","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1007\/s00406-006-0652-8","volume":"256","author":"C Yasutake","year":"2006","unstructured":"Yasutake, C., Kuroda, K., Yanagawa, T., Okamura, T., & Yoneda, H. (2006). Serum BDNF, TNF-\u03b1 and IL-1\u03b2 levels in dementia patients: Comparison between Alzheimer\u2019s disease and vascular dementia. European Archives of Psychiatry and Clinical Neuroscience, 256, 402\u2013406.","journal-title":"European Archives of Psychiatry and Clinical Neuroscience"},{"key":"8857_CR123","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.680765","volume":"12","author":"X Yi","year":"2021","unstructured":"Yi, X., Yang, Y., Zhao, Z., Xu, M., Zhang, Y., Sheng, Y., Tian, J., & Xu, Z. (2021). Serum mBDNF and ProBDNF expression levels as diagnosis clue for early stage Parkinson\u2019s disease. Frontiers in Neurology, 12, Article 680765.","journal-title":"Frontiers in Neurology"},{"key":"8857_CR124","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.redox.2016.12.034","volume":"11","author":"J-M Yoo","year":"2017","unstructured":"Yoo, J.-M., Lee, B. D., Sok, D.-E., Ma, J. Y., & Kim, M. R. (2017). Neuroprotective action of N-acetyl serotonin in oxidative stress-induced apoptosis through the activation of both TrkB\/CREB\/BDNF pathway and Akt\/Nrf2\/antioxidant enzyme in neuronal cells. Redox Biology, 11, 592\u2013599.","journal-title":"Redox Biology"},{"issue":"1","key":"8857_CR125","doi-asserted-by":"publisher","first-page":"29","DOI":"10.4103\/1673-5374.374138","volume":"19","author":"M Zagrebelsky","year":"2024","unstructured":"Zagrebelsky, M., & Korte, M. (2024). Are TrkB receptor agonists the right tool to fulfill the promises for a therapeutic value of the brain-derived neurotrophic factor? Neural Regeneration Research, 19(1), 29\u201334.","journal-title":"Neural Regeneration Research"},{"key":"8857_CR126","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106099","volume":"177","author":"SN Zarneshan","year":"2022","unstructured":"Zarneshan, S. N., Fakhri, S., & Khan, H. (2022). Targeting Akt\/CREB\/BDNF signaling pathway by ginsenosides in neurodegenerative diseases: A mechanistic approach. Pharmacological Research, 177, Article 106099.","journal-title":"Pharmacological Research"},{"issue":"1","key":"8857_CR127","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3109\/00207454.2016.1146882","volume":"127","author":"J Zhang","year":"2017","unstructured":"Zhang, J., Mu, X., Breker, D. A., Li, Y., Gao, Z., & Huang, Y. (2017). Atorvastatin treatment is associated with increased BDNF level and improved functional recovery after atherothrombotic stroke. International Journal of Neuroscience, 127(1), 92\u201397.","journal-title":"International Journal of Neuroscience"},{"key":"8857_CR128","unstructured":"\u68ee\u53cb\u7d00\u5b50. (2021). Serum BDNF as a potential biomarker of Alzheimer\u2019s disease: Verification through assessment of serum, cerebrospinal fluid, and medial temporal lobe atrophy \u662d\u548c\u5927\u5b66]."}],"container-title":["NeuroMolecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-025-08857-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12017-025-08857-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-025-08857-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T16:02:12Z","timestamp":1767196932000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12017-025-08857-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,17]]},"references-count":127,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["8857"],"URL":"https:\/\/doi.org\/10.1007\/s12017-025-08857-x","relation":{},"ISSN":["1559-1174"],"issn-type":[{"value":"1559-1174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,17]]},"assertion":[{"value":"9 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}],"article-number":"36"}}