{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:50:28Z","timestamp":1791402628880,"version":"4.3.3"},"reference-count":213,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuromol Med"],"DOI":"10.1007\/s12017-025-08870-0","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T06:18:02Z","timestamp":1751523482000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Dysbiosis and Neurodegeneration in ALS: Unraveling the Gut\u2013Brain Axis"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1678-4180","authenticated-orcid":false,"given":"Vivek Kumar","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"8870_CR1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/ijms20092280","volume":"20","author":"S Adesso","year":"2019","unstructured":"Adesso, S., Ruocco, M., Rapa, S. F., Piaz, F. D., Raffaele Di Iorio, B., Popolo, A., et al. (2019). Effect of indoxyl sulfate on the repair and intactness of intestinal epithelial cells: Role of reactive oxygen species\u2019 release. International Journal of Molecular Sciences, 20, 9.","journal-title":"International Journal of Molecular Sciences"},{"key":"8870_CR2","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s00401-012-1022-4","volume":"124","author":"A Al-Chalabi","year":"2012","unstructured":"Al-Chalabi, A., Jones, A., Troakes, C., King, A., Al-Sarraj, S., & van den Berg, L. H. (2012). The genetics and neuropathology of amyotrophic lateral sclerosis. Acta Neuropathologica, 124, 339\u2013352.","journal-title":"Acta Neuropathologica"},{"key":"8870_CR3","doi-asserted-by":"publisher","first-page":"166","DOI":"10.3934\/Neuroscience.2024.2.166","volume":"11","author":"U Ansari","year":"2024","unstructured":"Ansari, U., Alam, M., Nadora, D., Muttalib, Z., Chen, V., Taguinod, I., FitzPatrick, M., Wen, J., Ansari, Z., & Lui, F. (2024). Assessing the efficacy of amyotrophic lateral sclerosis drugs in slowing disease progression: A literature review. AIMS Neuroscience, 11, 166\u2013177. https:\/\/doi.org\/10.3934\/Neuroscience.2024.2.166","journal-title":"AIMS Neuroscience"},{"key":"8870_CR4","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1093\/brain\/awaa096","volume":"143","author":"ML Arotcarena","year":"2020","unstructured":"Arotcarena, M. L., Dovero, S., Prigent, A., et al. (2020). Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates. Brain, 143, 1462\u20131475.","journal-title":"Brain"},{"key":"8870_CR5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3390\/sclerosis3010008","volume":"3","author":"V Ayala","year":"2025","unstructured":"Ayala, V., Fontdevila, L., Rico-Rios, S., Povedano, M., Andr\u00e9s-Benito, P., Torres, P., Serrano, J. C. E., Pamplona, R., & Portero-Otin, M. (2025). Microbial influences on amyotrophic lateral sclerosis: The gut\u2013brain axis and therapeutic potential of microbiota modulation. Sclerosis, 3, 8.","journal-title":"Sclerosis"},{"key":"8870_CR6","doi-asserted-by":"publisher","first-page":"e00099","DOI":"10.1128\/MCB.00099-20","volume":"40","author":"L Baird","year":"2020","unstructured":"Baird, L., & Yamamoto, M. (2020). The molecular mechanisms regulating the KEAP1-NRF2 pathway. Molecular and Cellular Biology, 40, e00099.","journal-title":"Molecular and Cellular Biology"},{"key":"8870_CR7","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/ana.27126","volume":"97","author":"R Bedlack","year":"2024","unstructured":"Bedlack, R., Li, X., Evangelista, B. A., Panzetta, M. E., Kwan, J., Gittings, L. M., & Sattler, R. (2024). The scientific and therapeutic rationale for off-label treatments in amyotrophic lateral sclerosis. Annals of Neurology, 97, 15\u201327.","journal-title":"Annals of Neurology"},{"key":"8870_CR8","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1172\/jci.insight.89530","volume":"2","author":"R Beers","year":"2017","unstructured":"Beers, R., Zhao, W., Wang, J., et al. (2017). ALS patients\u2019 regulatory T lymphocytes are dysfunctional and correlate with disease progression rate and severity. JCI Insight, 2, 5.","journal-title":"JCI Insight"},{"key":"8870_CR9","doi-asserted-by":"publisher","first-page":"fcaa124","DOI":"10.1093\/braincomms\/fcaa124","volume":"2","author":"LC B\u00e9land","year":"2020","unstructured":"B\u00e9land, L. C., Markovinovic, A., Jakovac, H., De Marchi, F., Bilic, E., Mazzini, L., Kriz, J., & Munitic, I. (2020). Immunity in amyotrophic lateral sclerosis: Blurred lines between excessive inflammation and inefficient immune responses. Brain Communications, 2, fcaa124.","journal-title":"Brain Communications"},{"key":"8870_CR10","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/BF00370302","volume":"419","author":"E Benoit","year":"1991","unstructured":"Benoit, E., & Escande, D. (1991). Riluzole specifically blocks inactivated Na channels in myelinated nerve fibre. Pflugers Archiv, 419, 603\u2013609.","journal-title":"Pflugers Archiv"},{"key":"8870_CR11","doi-asserted-by":"publisher","first-page":"20523","DOI":"10.1073\/pnas.1006869107","volume":"107","author":"LG Bilsland","year":"2010","unstructured":"Bilsland, L. G., Sahai, E., Kelly, G., Golding, M., Greensmith, L., & Schiavo, G. (2010). Deficits in axonal transport precede ALS symptoms in vivo. Proceedings of the National Academy of Sciences USA, 107, 20523\u201320528.","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"8870_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-019-08453-9","volume":"10","author":"E Blacher","year":"2019","unstructured":"Blacher, E., Bashiardes, S., Shapiro, H., Rothschild, D., Mor, U., Dori-Bachash, M., et al. (2019a). Potential roles of gut microbiome and metabolites in modulating ALS pathogenesis. Nature Communications, 10, 1\u201310. https:\/\/doi.org\/10.1038\/s41467-019-08453-9","journal-title":"Nature Communications"},{"key":"8870_CR13","doi-asserted-by":"crossref","first-page":"5825","DOI":"10.1038\/s41467-019-13768-0","volume":"10","author":"E Blacher","year":"2019","unstructured":"Blacher, E., Bashiardes, S., Shapiro, H., Rothschild, D., Mor, U., Dori-Bachash, M., et al. (2019b). Potential roles of gut microbiome and metabolites in modulating ALS progression. Nature Communications, 10, 5825.","journal-title":"Nature Communications"},{"key":"8870_CR14","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/nrneurol.2017.44","volume":"13","author":"E Blacher","year":"2017","unstructured":"Blacher, E., Bashiardes, S., Shapiro, H., Rothschild, D., Mor, U., Dori-Bachash, M., Zvibel, I., Elinav, E., Segal, E., Halpern, Z., Amariglio, N., Ben-Haim, S., & Koren, O. (2017). The gut microbiome in neurodegenerative disorders. Nature Reviews Neurology, 13, 359\u2013371. https:\/\/doi.org\/10.1038\/nrneurol.2017.44","journal-title":"Nature Reviews Neurology"},{"key":"8870_CR15","first-page":"460","volume":"12","author":"H Blasco","year":"2018","unstructured":"Blasco, H., et al. (2018). Gut microbiota and amyotrophic lateral sclerosis: A potential mechanism. Frontiers in Cellular Neuroscience, 12, 460.","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"8870_CR16","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1007\/s00401-013-1125-6","volume":"125","author":"AM Blokhuis","year":"2013","unstructured":"Blokhuis, A. M., Groen, E. J., Koppers, M., van den Berg, L. H., & Pasterkamp, R. J. (2013). Protein aggregation in amyotrophic lateral sclerosis. Acta Neuropathologica, 125, 777\u2013794.","journal-title":"Acta Neuropathologica"},{"key":"8870_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12916-020-01885-3","volume":"19","author":"SL Boddy","year":"2021","unstructured":"Boddy, S. L., Giovannelli, I., Sassani, M., Cooper-Knock, J., Snyder, M. P., Segal, E., Elinav, E., Barker, L. A., Shaw, P. J., & McDermott, C. J. (2021). The gut microbiome: A key player in the complexity of amyotrophic lateral sclerosis (ALS). BMC Medicine, 19, 1\u201314.","journal-title":"BMC Medicine"},{"issue":"3","key":"8870_CR18","doi-asserted-by":"publisher","first-page":"429","DOI":"10.3390\/cells12030429","volume":"12","author":"F Borbolis","year":"2023","unstructured":"Borbolis, F., Mytilinaiou, E., & Palikaras, K. (2023). The crosstalk between microbiome and mitochondrial homeostasis in neurodegeneration. Cells, 12(3), 429.","journal-title":"Cells"},{"key":"8870_CR19","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1007\/s13311-022-01247-2","volume":"19","author":"BD Boros","year":"2022","unstructured":"Boros, B. D., Schoch, K. M., Kreple, C. J., & Miller, T. M. (2022). Antisense oligonucleotides for the study and treatment of ALS. Neurotherapeutics, 19, 1145\u20131158.","journal-title":"Neurotherapeutics"},{"key":"8870_CR20","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1093\/brain\/awx370","volume":"141","author":"D Brenner","year":"2018","unstructured":"Brenner, D., et al. (2018). Hot-spot KIF5A mutations cause familial ALS. Brain, 141, 688\u2013697.","journal-title":"Brain"},{"key":"8870_CR21","doi-asserted-by":"publisher","first-page":"256","DOI":"10.3390\/cells12010256","volume":"12","author":"D Brenner","year":"2023","unstructured":"Brenner, D., et al. (2023a). Gut microbiota and amyotrophic lateral sclerosis: A role for neuroinflammation. Cells, 12, 256. https:\/\/doi.org\/10.3390\/cells12010256","journal-title":"Cells"},{"issue":"1","key":"8870_CR22","first-page":"256","volume":"12","author":"D Brenner","year":"2023","unstructured":"Brenner, D., et al. (2023b). Gut microbiota and amyotrophic lateral sclerosis: A role for neuroinflammation. Cells, 12(1), 256.","journal-title":"Cells"},{"key":"8870_CR23","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/s41586-020-2288-7","volume":"582","author":"A Burberry","year":"2020","unstructured":"Burberry, A., Wells, M. F., Limone, F., Couto, A., Smith, K. S., Keaney, J., et al. (2020). C9orf72 suppresses systemic and neural inflammation induced by gut bacteria. Nature, 582, 89\u201394.","journal-title":"Nature"},{"key":"8870_CR24","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1007\/s00401-019-01964-7","volume":"137","author":"K Burk","year":"2019","unstructured":"Burk, K., & Pasterkamp, R. J. (2019). Disrupted neuronal trafficking in amyotrophic lateral sclerosis. Acta Neuropathologica, 137, 859\u2013877.","journal-title":"Acta Neuropathologica"},{"key":"8870_CR25","doi-asserted-by":"publisher","first-page":"712","DOI":"10.3389\/fgene.2018.00712","volume":"9","author":"Z Butti","year":"2019","unstructured":"Butti, Z., & Patten, S. A. (2019a). RNA dysregulation in amyotrophic lateral sclerosis. Frontiers in Genetics, 9, 712. https:\/\/doi.org\/10.3389\/fgene.2018.00712","journal-title":"Frontiers in Genetics"},{"key":"8870_CR26","doi-asserted-by":"publisher","first-page":"712","DOI":"10.3389\/fgene.2018.00712","volume":"9","author":"Z Butti","year":"2019","unstructured":"Butti, Z., & Patten, S. A. (2019b). RNA dysregulation in amyotrophic lateral sclerosis. Frontiers in Genetics, 9, 712.","journal-title":"Frontiers in Genetics"},{"key":"8870_CR27","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1523\/JNEUROSCI.20-01-00240.2000","volume":"20","author":"SG Carriedo","year":"2000","unstructured":"Carriedo, S. G., Sensi, S. L., Yin, H. Z., & Weiss, J. H. (2000). AMPA exposures induce mitochondrial Ca2+ overload and ROS generation in spinal motor neurons in vitro. Journal of Neuroscience, 20, 240\u2013250.","journal-title":"Journal of Neuroscience"},{"issue":"2","key":"8870_CR28","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3390\/metabo11020120","volume":"11","author":"J Casani-Cubel","year":"2021","unstructured":"Casani-Cubel, J., Benlloch, M., Sanchis-Sanchis, C. E., Marin, R., Lajara-Romance, J. M., & de la Rubia Orti, J. E. (2021). The impact of microbiota on the pathogenesis of amyotrophic lateral sclerosis and the possible benefits of polyphenols. An overview. Metabolites, 11(2), 120.","journal-title":"Metabolites"},{"key":"8870_CR29","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1007\/s10571-023-01234-5","volume":"43","author":"E Cecerska-Hery\u0107","year":"2023","unstructured":"Cecerska-Hery\u0107, E., P\u0119ka\u0142a, M., Serwin, N., et al. (2023). The use of stem cells as a potential treatment method for selected neurodegenerative diseases: Review. Cellular and Molecular Neurobiology, 43, 2643\u20132673. https:\/\/doi.org\/10.1007\/s10571-023-01234-5","journal-title":"Cellular and Molecular Neurobiology"},{"key":"8870_CR30","doi-asserted-by":"publisher","first-page":"74","DOI":"10.14336\/AD.2023.1231","volume":"15","author":"S Chen","year":"2024","unstructured":"Chen, S., Cai, X., Lao, L., Wang, Y., Su, H., & Sun, H. (2024). Brain-gut-microbiota axis in amyotrophic lateral sclerosis: A historical overview and future directions. Aging & Disease, 15, 74\u201395. https:\/\/doi.org\/10.14336\/AD.2023.1231","journal-title":"Aging & Disease"},{"key":"8870_CR31","doi-asserted-by":"publisher","first-page":"101","DOI":"10.2174\/157015906776359540","volume":"4","author":"L Ciranna","year":"2006","unstructured":"Ciranna, L. (2006). Serotonin as a modulator of glutamate- and GABA-mediated neurotransmission: Implications in physiological functions and in pathology. Current Neuropharmacology, 4, 101\u2013114.","journal-title":"Current Neuropharmacology"},{"key":"8870_CR32","doi-asserted-by":"publisher","first-page":"3526","DOI":"10.1093\/brain\/awaa309","volume":"143","author":"BE Clarke","year":"2020","unstructured":"Clarke, B. E., & Patani, R. (2020). The microglial component of amyotrophic lateral sclerosis. Brain, 143, 3526\u20133539.","journal-title":"Brain"},{"key":"8870_CR33","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1073\/pnas.1815961116","volume":"116","author":"E Coque","year":"2019","unstructured":"Coque, E., Salsac, C., Espinosa-Carrasco, G., Varga, B., Degauque, N., Cadoux, M., et al. (2019). Cytotoxic CD8+ T lymphocytes expressing ALS-causing SOD1 mutant selectively trigger death of spinal motoneurons. Proceedings of the National Academy of Sciences USA, 116, 2312\u20132317. https:\/\/doi.org\/10.1073\/pnas.1815961116","journal-title":"Proceedings of the National Academy of Sciences USA"},{"issue":"9","key":"8870_CR34","first-page":"e0238558","volume":"15","author":"P Corcia","year":"2020","unstructured":"Corcia, P., Tauber, C., Vercoullie, J., et al. (2020). Molecular imaging of microglial activation in amyotrophic lateral sclerosis. PLoS ONE, 15(9), e0238558.","journal-title":"PLoS ONE"},{"key":"8870_CR35","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/nrn3346","volume":"13","author":"JF Cryan","year":"2012","unstructured":"Cryan, J. F., & Dinan, T. G. (2012). Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour. Nature Reviews Neuroscience, 13, 701\u2013712.","journal-title":"Nature Reviews Neuroscience"},{"key":"8870_CR36","doi-asserted-by":"publisher","first-page":"5021694","DOI":"10.1155\/2020\/5021694","volume":"2020","author":"T Cunha-Oliveira","year":"2020","unstructured":"Cunha-Oliveira, T., Montezinho, L., Mendes, C., Firuzi, O., Saso, L., Oliveira, P. J., & Silva, F. S. G. (2020). Oxidative stress in amyotrophic lateral sclerosis: Pathophysiology and opportunities for pharmacological intervention. Oxidative Medicine and Cellular Longevity, 2020, 5021694.","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"8870_CR37","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.cmet.2012.03.019","volume":"15","author":"S Da Cruz","year":"2012","unstructured":"Da Cruz, S., Parone, P. A., Lopes, V. S., Lillo, C., McAlonis-Downes, M., Lee, S. K., Vetto, A. P., Petrosyan, S., Marsala, M., Murphy, A. N., Williams, D. S., Spiegelman, B. M., & Cleveland, D. W. (2012). Elevated PGC-1\u03b1 activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metabolism, 15, 778\u2013786.","journal-title":"Cell Metabolism"},{"key":"8870_CR38","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1007\/s40262-018-0655-4","volume":"57","author":"RP Dash","year":"2018","unstructured":"Dash, R. P., Babu, R. J., & Srinivas, N. R. (2018). Two decades-long journeys from riluzole to edaravone: Revisiting the clinical pharmacokinetics of the only two amyotrophic lateral sclerosis therapeutics. Clinical Pharmacokinetics, 57, 1385\u20131398.","journal-title":"Clinical Pharmacokinetics"},{"key":"8870_CR39","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1096\/fasebj.14.5.729","volume":"14","author":"E Daugas","year":"2000","unstructured":"Daugas, E., Susin, S. A., Zamzami, N., Ferri, K. F., Irinopoulou, T., Larochette, N., Prevost, M. C., Leber, B., Andrews, D., Penninger, J., & Kroemer, G. (2000). Mitochondrion\u2013nuclear translocation of AIF in apoptosis and necrosis. The FASEB Journal, 14, 729\u2013738.","journal-title":"The FASEB Journal"},{"key":"8870_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-020-01742-3","volume":"17","author":"SE Desale","year":"2020","unstructured":"Desale, S. E., & Chinnathambi, S. (2020). Role of dietary fatty acids in microglial polarization in Alzheimer\u2019s disease. Journal of Neuroinflammation, 17, 1\u201314.","journal-title":"Journal of Neuroinflammation"},{"key":"8870_CR41","doi-asserted-by":"publisher","first-page":"3985","DOI":"10.3390\/ijms22083985","volume":"22","author":"M Deshimaru","year":"2021","unstructured":"Deshimaru, M., Kinoshita-Kawada, M., Kubota, K., Watanabe, T., Tanaka, Y., Hirano, S., et al. (2021). DCTN1 binds to TDP-43 and regulates TDP-43 aggregation. International Journal of Molecular Sciences, 22, 3985. https:\/\/doi.org\/10.3390\/ijms22083985","journal-title":"International Journal of Molecular Sciences"},{"key":"8870_CR42","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.gtc.2016.09.007","volume":"46","author":"TG Dinan","year":"2017","unstructured":"Dinan, T. G., & Cryan, J. F. (2017). The microbiome-gut-brain axis in health and disease. Gastroenterology Clinics of North America, 46, 77\u201389. https:\/\/doi.org\/10.1016\/j.gtc.2016.09.007","journal-title":"Gastroenterology Clinics of North America"},{"issue":"6 Suppl 4","key":"8870_CR43","first-page":"S233","volume":"47","author":"A Doble","year":"1996","unstructured":"Doble, A. (1996). The pharmacology and mechanism of action of riluzole. Neurology, 47(6 Suppl 4), S233\u2013S241.","journal-title":"Neurology"},{"key":"8870_CR44","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1038\/nature02261","volume":"426","author":"CM Dobson","year":"2003","unstructured":"Dobson, C. M. (2003). Protein folding and misfolding. Nature, 426, 884\u2013890.","journal-title":"Nature"},{"key":"8870_CR45","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/aps.2009.24","volume":"30","author":"XX Dong","year":"2009","unstructured":"Dong, X. X., Wang, Y., & Qin, Z. H. (2009). Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases. Acta Pharmacologica Sinica, 30, 379\u2013387.","journal-title":"Acta Pharmacologica Sinica"},{"issue":"13","key":"8870_CR46","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1212\/01.wnl.0000285080.70324.27","volume":"70","author":"L Dupuis","year":"2008","unstructured":"Dupuis, L., et al. (2008). Dyslipidemia is a protective factor in amyotrophic lateral sclerosis. Neurology, 70(13), 1004\u20131009.","journal-title":"Neurology"},{"key":"8870_CR47","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1038\/nn.4030","volume":"18","author":"D Erny","year":"2015","unstructured":"Erny, D., De Angelis, A. L. H., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015). Host microbiota constantly control maturation and function of microglia in the CNS. Nature Neuroscience, 18, 965\u2013977.","journal-title":"Nature Neuroscience"},{"key":"8870_CR48","doi-asserted-by":"publisher","first-page":"3703","DOI":"10.1093\/hmg\/dds205","volume":"21","author":"C Fallini","year":"2012","unstructured":"Fallini, C., Bassell, G. J., & Rossoll, W. (2012). The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth. Human Molecular Genetics, 21, 3703\u20133718.","journal-title":"Human Molecular Genetics"},{"key":"8870_CR49","volume":"16","author":"P Fang","year":"2022","unstructured":"Fang, P., Kazim, L., Li, S., Nachmanson, D., Na, C. H., Kopchick, J. J., et al. (2022). Gut microbiota-derived lipopolysaccharide induces neuroinflammation and aggravates protein aggregation in ALS. Frontiers in Cellular Neuroscience, 16, Article 879430.","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"8870_CR50","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1001\/jamaneurol.2013.234","volume":"70","author":"BR Foerster","year":"2013","unstructured":"Foerster, B. R., Pomper, M. G., Callaghan, B. C., Petrou, M., Edden, R. A., Mohamed, M. A., Welsh, R. C., Carlos, R. C., Barker, P. B., & Feldman, E. L. (2013). An imbalance between excitatory and inhibitory neurotransmitters in amyotrophic lateral sclerosis revealed by use of 3-T proton magnetic resonance spectroscopy. JAMA Neurology, 70, 1009\u20131016.","journal-title":"JAMA Neurology"},{"key":"8870_CR51","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1089\/ars.2009.2444","volume":"11","author":"E Foran","year":"2009","unstructured":"Foran, E., & Trotti, D. (2009). Glutamate transporters and the excitotoxic path to motor neuron degeneration in amyotrophic lateral sclerosis. Antioxidants & Redox Signaling, 11, 1587\u20131602.","journal-title":"Antioxidants & Redox Signaling"},{"key":"8870_CR52","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s11154-019-09511-3","volume":"20","author":"CB Forsyth","year":"2019","unstructured":"Forsyth, C. B., Shannon, K. M., Kordower, J. H., Vo, N., Shaikh, M., Jaglin, J. A., Estes, J. D., & Fox, H. S. (2019). Role of the gut microbiota in neuroinflammatory and neurodegenerative diseases. Reviews in Endocrine & Metabolic Disorders, 20, 387\u2013397. https:\/\/doi.org\/10.1007\/s11154-019-09511-3","journal-title":"Reviews in Endocrine & Metabolic Disorders"},{"key":"8870_CR53","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/nature12721","volume":"504","author":"Y Furusawa","year":"2013","unstructured":"Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013). Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature, 504, 446\u2013450. https:\/\/doi.org\/10.1038\/nature12721","journal-title":"Nature"},{"key":"8870_CR54","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.brainres.2012.05.056","volume":"1469","author":"S Garbuzova-Davis","year":"2012","unstructured":"Garbuzova-Davis, S., Hernandez-Ontiveros, D. G., Rodrigues, M. C. O., Haller, E., Frisina-Deyo, A., Mirtyl, S., Sallot, S., Saporta, S., Borlongan, C. V., & Sanberg, P. R. (2012). Impaired blood\u2013brain\/spinal cord barrier in ALS patients. Brain Research, 1469, 114\u2013128.","journal-title":"Brain Research"},{"key":"8870_CR55","first-page":"765","volume":"19","author":"ME Garcia","year":"2022","unstructured":"Garcia, M. E., et al. (2022). Therapeutic potential of modulating the gut microbiome in neurodegenerative disorders. Neurotherapeutics, 19, 765\u2013782.","journal-title":"Neurotherapeutics"},{"issue":"11","key":"8870_CR56","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.3390\/genes14111981","volume":"14","author":"EC Genin","year":"2023","unstructured":"Genin, E. C., Abou-Ali, M., & Paquis-Flucklinger, V. (2023). Mitochondria, a key target in amyotrophic lateral sclerosis pathogenesis. Genes, 14(11), 1981. https:\/\/doi.org\/10.3390\/genes14111981","journal-title":"Genes"},{"key":"8870_CR57","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1006\/nbdi.2000.0295","volume":"7","author":"JL Gonz\u00e1lez de Aguilar","year":"2000","unstructured":"Gonz\u00e1lez de Aguilar, J. L., Gordon, J. W., Ren\u00e9, F., de Tapia, M., Lutz-Bucher, B., Gaiddon, C., & Loeffler, J. P. (2000). Alteration of the Bcl-x\/Bax ratio in a transgenic mouse model of amyotrophic lateral sclerosis: Evidence for the implication of the p53 signaling pathway. Neurobiology of Diseases, 7, 406\u2013415.","journal-title":"Neurobiology of Diseases"},{"key":"8870_CR58","doi-asserted-by":"publisher","first-page":"647","DOI":"10.3390\/life15040647","volume":"15","author":"M Gonz\u00e1lez-S\u00e1nchez","year":"2025","unstructured":"Gonz\u00e1lez-S\u00e1nchez, M., Ram\u00edrez-Exp\u00f3sito, M. J., & Mart\u00ednez-Martos, J. M. (2025). Pathophysiology, clinical heterogeneity, and therapeutic advances in amyotrophic lateral sclerosis: A comprehensive review of molecular mechanisms, diagnostic challenges, and multidisciplinary management strategies. Life, 15, 647. https:\/\/doi.org\/10.3390\/life15040647","journal-title":"Life"},{"key":"8870_CR59","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.91963","author":"W Guo","year":"2020","unstructured":"Guo, W., Fumagalli, L., & Van Den Bosch, L. (2020). Targeting axonal transport: A new therapeutic avenue for ALS. IntechOpen. https:\/\/doi.org\/10.5772\/intechopen.91963","journal-title":"IntechOpen"},{"key":"8870_CR60","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1007\/s10072-023-06817-7","volume":"45","author":"AA Hamad","year":"2024","unstructured":"Hamad, A. A., Amer, B. E., Hawas, Y., Mabrouk, M. A., & Meshref, M. (2024). Masitinib as a neuroprotective agent: A scoping review of preclinical and clinical evidence. Neurological Sciences, 45, 1861\u20131873. https:\/\/doi.org\/10.1007\/s10072-023-06817-7","journal-title":"Neurological Sciences"},{"key":"8870_CR61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.conb.2019.11.007","volume":"62","author":"S Hazan","year":"2020","unstructured":"Hazan, S., Dave, S., Patrizio, A., et al. (2020). Microbiome and neurodegeneration: Links to ALS. Current Opinion in Neurobiology, 62, 1\u20136.","journal-title":"Current Opinion in Neurobiology"},{"key":"8870_CR62","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1080\/21678421.2021.1918722","volume":"23","author":"J He","year":"2022","unstructured":"He, J., Yu, W., Liu, X., & Fan, D. (2022). An identical DCTN1 mutation in two Chinese siblings manifest as dHMN and ALS respectively: A case report. Amyotroph Lateral Scler Frontotemporal Degener, 23, 149\u2013153. https:\/\/doi.org\/10.1080\/21678421.2021.1918722","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"8870_CR63","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1038\/sj.cdd.4402166","volume":"14","author":"C Hetz","year":"2007","unstructured":"Hetz, C., Thielen, P., Fisher, J., Pasinelli, P., Brown, R. H., Korsmeyer, S., & Glimcher, L. (2007). The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis. Cell Death and Differentiation, 14, 1386\u20131389. https:\/\/doi.org\/10.1038\/sj.cdd.4402166","journal-title":"Cell Death and Differentiation"},{"key":"8870_CR64","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1111\/nan.12148","volume":"40","author":"JR Highley","year":"2014","unstructured":"Highley, J. R., Kirby, J., Jansweijer, J. A., et al. (2014). Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurons. Neuropathology and Applied Neurobiology, 40, 670\u2013685.","journal-title":"Neuropathology and Applied Neurobiology"},{"key":"8870_CR65","doi-asserted-by":"publisher","first-page":"61","DOI":"10.2147\/DNND.S135748","volume":"7","author":"M Hinchcliffe","year":"2017","unstructured":"Hinchcliffe, M., & Smith, A. (2017). Riluzole: Real-world evidence supports significant extension of median survival times in patients with amyotrophic lateral sclerosis. Degenerative Neurological and Neuromuscular Disease, 7, 61\u201370.","journal-title":"Degenerative Neurological and Neuromuscular Disease"},{"key":"8870_CR66","doi-asserted-by":"publisher","first-page":"294","DOI":"10.3109\/10409238.2014.914151","volume":"49","author":"WM Holmes","year":"2014","unstructured":"Holmes, W. M., Klaips, C. L., & Serio, T. R. (2014). Defining the limits: Protein aggregation and toxicity in vivo. Critical Reviews in Biochemistry and Molecular Biology, 49, 294\u2013303.","journal-title":"Critical Reviews in Biochemistry and Molecular Biology"},{"key":"8870_CR67","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.4103\/1673-5374.382985","volume":"19","author":"Y Hu","year":"2024","unstructured":"Hu, Y., Chen, W., Wei, C., Jiang, S., Li, S., Wang, X., & Xu, R. (2024). Pathological mechanisms of amyotrophic lateral sclerosis. Neural Regeneration Research, 19, 1036\u20131044. https:\/\/doi.org\/10.4103\/1673-5374.382985","journal-title":"Neural Regeneration Research"},{"key":"8870_CR68","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3389\/fnins.2014.00355","volume":"8","author":"MA Huntley","year":"2014","unstructured":"Huntley, M. A., Bien-Ly, N., Daneman, R., & Watts, R. J. (2014). Dissecting gene expression at the blood-brain barrier. Frontiers in Neuroscience, 8, 355.","journal-title":"Frontiers in Neuroscience"},{"key":"8870_CR69","doi-asserted-by":"publisher","first-page":"1047897","DOI":"10.3389\/fnagi.2023.1047897","volume":"15","author":"YM Jeon","year":"2023","unstructured":"Jeon, Y. M., Kwon, Y., Lee, S., & Kim, H. J. (2023). Potential roles of the endoplasmic reticulum stress pathway in amyotrophic lateral sclerosis. Frontiers in Aging Neuroscience, 15, 1047897.","journal-title":"Frontiers in Aging Neuroscience"},{"key":"8870_CR70","doi-asserted-by":"publisher","first-page":"1054006","DOI":"10.3389\/fphar.2022.1054006","volume":"13","author":"J Jiang","year":"2022","unstructured":"Jiang, J., Wang, Y., & Deng, M. (2022). New developments and opportunities in drugs being trialed for amyotrophic lateral sclerosis from 2020 to 2022. Frontiers in Pharmacology, 13, 1054006. https:\/\/doi.org\/10.3389\/fphar.2022.1054006","journal-title":"Frontiers in Pharmacology"},{"key":"8870_CR71","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1111\/febs.14589","volume":"286","author":"H Kadowaki","year":"2019","unstructured":"Kadowaki, H., & Nishitoh, H. (2019). Endoplasmic reticulum quality control by garbage disposal. FEBS Journal, 286, 232\u2013240.","journal-title":"FEBS Journal"},{"key":"8870_CR72","doi-asserted-by":"publisher","first-page":"2537698","DOI":"10.1155\/2019\/2537698","volume":"2019","author":"N Kakaroubas","year":"2019","unstructured":"Kakaroubas, N., Brennan, S., Keon, M., & Saksena, N. K. (2019). Pathomechanisms of blood-brain barrier disruption in ALS. Neuroscience Journal, 2019, 2537698.","journal-title":"Neuroscience Journal"},{"key":"8870_CR73","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1111\/j.1471-4159.2008.05595.x","volume":"107","author":"B Kalmar","year":"2008","unstructured":"Kalmar, B., Novoselov, S., Gray, A., Cheetham, M. E., Margulis, B., & Greensmith, L. (2008). Late-stage treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1 mouse model of ALS. Journal of Neurochemistry, 107, 339\u2013350.","journal-title":"Journal of Neurochemistry"},{"key":"8870_CR74","doi-asserted-by":"publisher","first-page":"e00469","DOI":"10.1016\/j.neurot.2024.e00469","volume":"21","author":"M Kaul","year":"2024","unstructured":"Kaul, M., Mukherjee, D., Weiner, H. L., & Cox, L. M. (2024). Gut microbiota immune crosstalk in amyotrophic lateral sclerosis. Neurotherapeutics, 21, e00469.","journal-title":"Neurotherapeutics"},{"issue":"3","key":"8870_CR75","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.3233\/JAD-200436","volume":"76","author":"H Kaur","year":"2020","unstructured":"Kaur, H., Golovko, S., Golovko, M. Y., Singh, S., Darland, D. C., & Combs, C. K. (2020). Effects of probiotic supplementation on short chain fatty acids in the AppNL-G-F mouse model of Alzheimer\u2019s disease. Journal of Alzheimer\u2019s Disease, 76(3), 1083\u20131102.","journal-title":"Journal of Alzheimer's Disease"},{"key":"8870_CR76","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s40035-022-00299-2","volume":"11","author":"K Khalaf","year":"2022","unstructured":"Khalaf, K., Tornese, P., Cocco, A., et al. (2022). Tauroursodeoxycholic acid: A potential therapeutic tool in neurodegenerative diseases. Translational Neurodegeneration, 11, 33. https:\/\/doi.org\/10.1186\/s40035-022-00299-2","journal-title":"Translational Neurodegeneration"},{"key":"8870_CR77","doi-asserted-by":"publisher","first-page":"1145241","DOI":"10.3389\/fnagi.2023.1145241","volume":"15","author":"S Khatoon","year":"2023","unstructured":"Khatoon, S., Kalam, N., Rashid, S., & Bano, G. (2023). Effects of gut microbiota on neurodegenerative diseases. Frontiers in Aging Neuroscience, 15, 1145241. https:\/\/doi.org\/10.3389\/fnagi.2023.1145241","journal-title":"Frontiers in Aging Neuroscience"},{"key":"8870_CR78","first-page":"1188","volume":"52","author":"SM Kim","year":"2020","unstructured":"Kim, S. M., Kim, H., Lee, J. S., Park, K. S., Jeon, G. S., Shon, J., et al. (2020). Gut microbiome analysis reveals alterations in the ALS microbiota and suggests probiotics as a therapeutic strategy. Experimental & Molecular Medicine, 52, 1188\u20131197.","journal-title":"Experimental & Molecular Medicine"},{"key":"8870_CR79","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/S0891-5849(98)00216-0","volume":"26","author":"AJ Kowaltowski","year":"1999","unstructured":"Kowaltowski, A. J., & Vercesi, A. E. (1999). Mitochondrial damage induced by conditions of oxidative stress. Free Radical Biology & Medicine, 26, 463\u2013471. https:\/\/doi.org\/10.1016\/S0891-5849(98)00216-0","journal-title":"Free Radical Biology & Medicine"},{"key":"8870_CR80","doi-asserted-by":"publisher","first-page":"107327482412636","DOI":"10.1177\/10732748241263650","volume":"31","author":"G Kwao-Zigah","year":"2024","unstructured":"Kwao-Zigah, G., Bediako-Bowan, A., Boateng, P. A., et al. (2024). Microbiome dysbiosis, dietary intake and lifestyle-associated factors involve in epigenetic modulations in colorectal cancer: A narrative review. Cancer Control, 31, 10732748241263650. https:\/\/doi.org\/10.1177\/10732748241263650","journal-title":"Cancer Control"},{"key":"8870_CR81","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1038\/s42003-022-04327-3","volume":"5","author":"A Labarre","year":"2022","unstructured":"Labarre, A., Guitard, E., Tossing, G., Forest, A., Bareke, E., Labrecque, M., T\u00e9treault, M., Ruiz, M., & Parker, J. A. (2022). Fatty acids derived from the probiotic Lacticaseibacillus rhamnosus HA-114 suppress age-dependent neurodegeneration. Communications Biology, 5, 1340. https:\/\/doi.org\/10.1038\/s42003-022-04327-3","journal-title":"Communications Biology"},{"key":"8870_CR82","doi-asserted-by":"publisher","first-page":"e1361","DOI":"10.1212\/WNL.0000000000201604","volume":"100","author":"L Lacomblez","year":"2023","unstructured":"Lacomblez, L., et al. (2023). A phase 2\/3 study of Reldesemtiv in patients with amyotrophic lateral sclerosis: AMO104. Neurology, 100, e1361\u2013e1371. https:\/\/doi.org\/10.1212\/WNL.0000000000201604","journal-title":"Neurology"},{"key":"8870_CR83","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1016\/S0140-6736(96)91680-3","volume":"347","author":"L Lacomblez","year":"1996","unstructured":"Lacomblez, L., Bensimon, G., Leigh, P. N., Guillet, P., & Meininger, V. (1996a). Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis\/Riluzole study group II. Lancet, 347, 1425\u20131431.","journal-title":"Lancet"},{"key":"8870_CR84","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1016\/S0140-6736(96)91680-3","volume":"347","author":"L Lacomblez","year":"1996","unstructured":"Lacomblez, L., Bensimon, G., Leigh, P. N., Guillet, P., & Meininger, V. (1996b). Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis\/Riluzole Study Group II. Lancet, 347, 1425\u20131431.","journal-title":"Lancet"},{"key":"8870_CR85","doi-asserted-by":"publisher","first-page":"R46","DOI":"10.1093\/hmg\/ddq137","volume":"19","author":"C Lagier-Tourenne","year":"2010","unstructured":"Lagier-Tourenne, C., Polymenidou, M., & Cleveland, D. W. (2010). TDP-43 and FUS\/TLS: Emerging roles in RNA processing and neurodegeneration. Human Molecular Genetics, 19, R46\u2013R64.","journal-title":"Human Molecular Genetics"},{"key":"8870_CR86","doi-asserted-by":"publisher","first-page":"11798","DOI":"10.1523\/JNEUROSCI.2084-06.2006","volume":"26","author":"C Lai","year":"2006","unstructured":"Lai, C., et al. (2006). Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. Journal of Neuroscience, 26, 11798\u201311806.","journal-title":"Journal of Neuroscience"},{"key":"8870_CR87","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/j.1749-6632.1990.tb16891.x","volume":"600","author":"JM Lauder","year":"1990","unstructured":"Lauder, J. M. (1990). Ontogeny of the serotonergic system in the rat: Serotonin as a developmental signal. Annals of the New York Academy of Sciences, 600, 297\u2013313. https:\/\/doi.org\/10.1111\/j.1749-6632.1990.tb16891.x","journal-title":"Annals of the New York Academy of Sciences"},{"key":"8870_CR88","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.3390\/ijms25031871","volume":"25","author":"A Lee","year":"2024","unstructured":"Lee, A., Henderson, R., Aylward, J., & McCombe, P. (2024). Gut symptoms, gut dysbiosis and gut-derived toxins in ALS. International Journal of Molecular Sciences, 25, 1871. https:\/\/doi.org\/10.3390\/ijms25031871","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"8870_CR89","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12974-023-02704-1","volume":"20","author":"S Lee","year":"2023","unstructured":"Lee, S., et al. (2023). Peripheral T cell infiltration exacerbates neuroinflammation and neurodegeneration in amyotrophic lateral sclerosis. J Neuroinflamm, 20(1), 19.","journal-title":"J Neuroinflamm"},{"key":"8870_CR90","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1523\/JNEUROSCI.5159-07.2008","volume":"28","author":"D Leonoudakis","year":"2008","unstructured":"Leonoudakis, D., Zhao, P., & Beattie, E. C. (2008). Rapid tumor necrosis factor alpha-induced exocytosis of glutamate receptor 2-lacking AMPA receptors to extrasynaptic plasma membrane potentiates excitotoxicity. Journal of Neuroscience, 28, 2119\u20132130.","journal-title":"Journal of Neuroscience"},{"key":"8870_CR91","doi-asserted-by":"publisher","first-page":"7688","DOI":"10.3390\/ijms22147688","volume":"22","author":"P Li","year":"2021","unstructured":"Li, P., & Chang, M. (2021). Roles of PRR-mediated signaling pathways in the regulation of oxidative stress and inflammatory diseases. International Journal of Molecular Sciences, 22, 7688.","journal-title":"International Journal of Molecular Sciences"},{"issue":"4","key":"8870_CR92","first-page":"2133","volume":"58","author":"X Li","year":"2021","unstructured":"Li, X., et al. (2021). Autophagy, RNA metabolism, and the microbiota: New insights into ALS pathogenesis. Molecular Neurobiology, 58(4), 2133\u20132146.","journal-title":"Molecular Neurobiology"},{"key":"8870_CR93","doi-asserted-by":"publisher","first-page":"3745","DOI":"10.1007\/s12035-021-02375-0","volume":"58","author":"Y Liang","year":"2021","unstructured":"Liang, Y., Cui, L., Gao, J., Zhu, M., Zhang, Y., & Zhang, H. L. (2021). Gut microbial metabolites in Parkinson\u2019s disease: Implications of mitochondrial dysfunction in the pathogenesis and treatment. Molecular Neurobiology, 58, 3745\u20133758.","journal-title":"Molecular Neurobiology"},{"key":"8870_CR94","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/S0896-6273(00)80997-6","volume":"20","author":"CL Lin","year":"1998","unstructured":"Lin, C. L., Bristol, L. A., Jin, L., Dykes-Hoberg, M., Crawford, T., Clawson, L., et al. (1998). Aberrant RNA processing in a neurodegenerative disease: The cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis. Neuron, 20, 589\u2013602.","journal-title":"Neuron"},{"key":"8870_CR95","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.neuron.2013.07.033","volume":"79","author":"SC Ling","year":"2013","unstructured":"Ling, S. C., Polymenidou, M., & Cleveland, D. W. (2013). Converging mechanisms in ALS and FTD: Disrupted RNA and protein homeostasis. Neuron, 79, 416\u2013438.","journal-title":"Neuron"},{"key":"8870_CR96","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.3389\/fimmu.2017.01005","volume":"8","author":"J Liu","year":"2017","unstructured":"Liu, J., & Wang, F. (2017). Role of neuroinflammation in amyotrophic lateral sclerosis: Cellular mechanisms and therapeutic implications. Frontiers in Immunology, 8, 1005.","journal-title":"Frontiers in Immunology"},{"key":"8870_CR97","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.cell.2022.12.038","volume":"186","author":"C L\u00f3pez-Ot\u00edn","year":"2023","unstructured":"L\u00f3pez-Ot\u00edn, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023). Hallmarks of aging: An expanding universe. Cell, 186, 243\u2013278. https:\/\/doi.org\/10.1016\/j.cell.2022.12.038","journal-title":"Cell"},{"key":"8870_CR98","doi-asserted-by":"publisher","first-page":"1402962","DOI":"10.3389\/fneur.2024.1402962","volume":"15","author":"L Lu","year":"2024","unstructured":"Lu, L., Deng, Y., & Xu, R. (2024). Current potential therapeutics of amyotrophic lateral sclerosis. Frontiers in Neurology, 15, 1402962. https:\/\/doi.org\/10.3389\/fneur.2024.1402962","journal-title":"Frontiers in Neurology"},{"key":"8870_CR99","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1126\/science.1227157","volume":"338","author":"KC Luk","year":"2012","unstructured":"Luk, K. C., Kehm, V., Carroll, J., et al. (2012). Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science, 338, 949\u2013953.","journal-title":"Science"},{"key":"8870_CR100","doi-asserted-by":"publisher","first-page":"eaah3924","DOI":"10.1126\/scitranslmed.aah3924","volume":"10","author":"M Maier","year":"2018","unstructured":"Maier, M., Welt, T., Wirth, F., Montrasio, F., Preisig, D., McAfoose, J., et al. (2018). A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis. Science Translational Medicine, 10, eaah3924.","journal-title":"Science Translational Medicine"},{"key":"8870_CR101","doi-asserted-by":"publisher","first-page":"651","DOI":"10.3390\/antiox12030651","volume":"12","author":"E Maldonado","year":"2023","unstructured":"Maldonado, E., Morales-Pison, S., Urbina, F., & Solari, A. (2023). Aging hallmarks and the role of oxidative stress. Antioxidants (Basel), 12, 651.","journal-title":"Antioxidants (Basel)"},{"key":"8870_CR102","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3389\/fnmol.2020.00098","volume":"13","author":"R Malik","year":"2020","unstructured":"Malik, R., & Wiedau, M. (2020). Therapeutic approaches targeting protein aggregation in amyotrophic lateral sclerosis. Frontiers in Molecular Neuroscience, 13, 98.","journal-title":"Frontiers in Molecular Neuroscience"},{"key":"8870_CR103","first-page":"10","volume":"23","author":"S Manske","year":"2024","unstructured":"Manske, S. (2024). Lifestyle medicine and the microbiome: Holistic prevention and treatment. Integrative Medicine (Encinitas), 23, 10\u201314.","journal-title":"Integrative Medicine (Encinitas)"},{"issue":"11","key":"8870_CR104","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1002\/acn3.51887","volume":"10","author":"NJ Maragakis","year":"2023","unstructured":"Maragakis, N. J., de Carvalho, M., & Weiss, M. D. (2023). Therapeutic targeting of ALS pathways: Refocusing an incomplete picture. Annals of Clinical Translational Neurology, 10(11), 1948\u20131971.","journal-title":"Annals of Clinical Translational Neurology"},{"key":"8870_CR105","first-page":"788","volume":"2024","author":"N Marchal","year":"2025","unstructured":"Marchal, N., Janes, W. E., Earwood, J. H., Mosa, A. S. M., Popescu, M., Skubic, M., & Song, X. (2025). Integrating multi-sensor time-series data for ALSFRS-R clinical scale predictions in an ALS patient case study. American Medical Informatics Association Annual Symposium Proceedings, 2024, 788\u2013797.","journal-title":"American Medical Informatics Association Annual Symposium Proceedings"},{"key":"8870_CR106","doi-asserted-by":"publisher","first-page":"839526","DOI":"10.3389\/fcimb.2022.839526","volume":"12","author":"S Martin","year":"2022","unstructured":"Martin, S., Battistini, C., & Sun, J. (2022). A gut feeling in amyotrophic lateral sclerosis: Microbiome of mice and men. Frontiers in Cellular and Infection Microbiology, 12, 839526. https:\/\/doi.org\/10.3389\/fcimb.2022.839526","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"8870_CR107","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1111\/ene.14393","volume":"27","author":"P Masrori","year":"2020","unstructured":"Masrori, P., & Van Damme, P. (2020). Amyotrophic lateral sclerosis: A clinical review. European Journal of Neurology, 27, 1918\u20131929.","journal-title":"European Journal of Neurology"},{"key":"8870_CR108","doi-asserted-by":"publisher","first-page":"e89596","DOI":"10.1371\/journal.pone.0089596","volume":"9","author":"C May","year":"2014","unstructured":"May, C., Nordhoff, E., Casjens, S., Turewicz, M., Eisenacher, M., Gold, R., et al. (2014). Highly immunoreactive IgG antibodies directed against a set of twenty human proteins in the sera of patients with amyotrophic lateral sclerosis identified by protein array. PLoS ONE, 9, e89596. https:\/\/doi.org\/10.1371\/journal.pone.0089596","journal-title":"PLoS ONE"},{"key":"8870_CR109","volume-title":"Amyotrophic lateral sclerosis","author":"L Mazzini","year":"2021","unstructured":"Mazzini, L., De Marchi, F., Niccolai, E., Mandrioli, J., & Amedei, A. (2021). Gastrointestinal status and microbiota shaping in amyotrophic lateral sclerosis: a new frontier for targeting. In T. Araki (Ed.), Amyotrophic lateral sclerosis. Brisbane: Exon Publications."},{"key":"8870_CR110","doi-asserted-by":"publisher","first-page":"14774","DOI":"10.1038\/ncomms14774","volume":"8","author":"RL McLaughlin","year":"2017","unstructured":"McLaughlin, R. L., Schijven, D., van Rheenen, W., et al. (2017). Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nature Communications, 8, 14774.","journal-title":"Nature Communications"},{"key":"8870_CR111","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/s41573-022-00612-2","volume":"22","author":"RJ Mead","year":"2023","unstructured":"Mead, R. J., Shan, N., Reiser, H. J., et al. (2023). Amyotrophic lateral sclerosis: A neurodegenerative disorder poised for successful therapeutic translation. Nature Reviews Drug Discovery, 22, 185\u2013212.","journal-title":"Nature Reviews Drug Discovery"},{"key":"8870_CR112","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1007\/s00702-017-1732-9","volume":"125","author":"AS Mendiola","year":"2018","unstructured":"Mendiola, A. S., & Cardona, A. E. (2018). The IL-1\u03b2 phenomena in neuroinflammatory diseases. Journal of Neural Transmission (Vienna), 125, 781\u2013795.","journal-title":"Journal of Neural Transmission (Vienna)"},{"key":"8870_CR113","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1080\/21541248.2016.1277001","volume":"9","author":"ML Mignogna","year":"2018","unstructured":"Mignogna, M. L., & D\u2019Adamo, P. (2018). Critical importance of RAB proteins for synaptic function. Small GTPases, 9, 145\u2013157.","journal-title":"Small GTPases"},{"key":"8870_CR114","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/mus.27424","volume":"66","author":"RG Miller","year":"2022","unstructured":"Miller, R. G., Zhang, R., Bracci, P. M., Azhir, A., Barohn, R., Bedlack, R., Benatar, M., Berry, J. D., Cudkowicz, M., Kasarskis, E. J., Mitsumoto, H., Manousakis, G., Walk, D., Oskarsson, B., Shefner, J., & McGrath, M. S. (2022). Phase 2B randomized controlled trial of NP001 in amyotrophic lateral sclerosis: Pre-specified and post hoc analyses. Muscle and Nerve, 66, 39\u201349. https:\/\/doi.org\/10.1002\/mus.27424","journal-title":"Muscle and Nerve"},{"key":"8870_CR115","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1080\/17482960801933942","volume":"9","author":"H Mitsumoto","year":"2008","unstructured":"Mitsumoto, H., Santella, R., Liu, X., et al. (2008). Oxidative stress biomarkers in sporadic ALS. Amyotrophic Lateral Sclerosis, 9, 177\u2013183.","journal-title":"Amyotrophic Lateral Sclerosis"},{"key":"8870_CR116","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/s41598-023-35689-5","volume":"13","author":"Y Miyazaki","year":"2023","unstructured":"Miyazaki, Y., Araki, T., Morimoto, N., Suzuki, S., Kurata, T., Ikeda, Y., & Abe, K. (2023). Lactobacillus paracasei GMNL-32, a probiotic strain, attenuates motor dysfunction, neuroinflammation, and neurodegeneration in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Science and Reports, 13, 81. https:\/\/doi.org\/10.1038\/s41598-023-35689-5","journal-title":"Science and Reports"},{"issue":"3","key":"8870_CR117","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s10123-018-00051-3","volume":"22","author":"G Mohammadi","year":"2019","unstructured":"Mohammadi, G., Dargahi, L., Naserpour, T., Mirzanejad, Y., Alizadeh, S. A., Peymani, A., & Nassiri-Asl, M. (2019). Probiotic mixture of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 attenuates hippocampal apoptosis induced by lipopolysaccharide in rats. International Microbiology, 22(3), 317\u2013323.","journal-title":"International Microbiology"},{"key":"8870_CR118","doi-asserted-by":"publisher","first-page":"3020","DOI":"10.3390\/ijms19103020","volume":"19","author":"HW Moon","year":"2018","unstructured":"Moon, H. W., Han, H. G., & Jeon, Y. J. (2018). Protein quality control in the endoplasmic reticulum and cancer. International Journal of Molecular Sciences, 19, 3020.","journal-title":"International Journal of Molecular Sciences"},{"key":"8870_CR119","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1093\/hmg\/dds011","volume":"21","author":"GM M\u00f3rotz","year":"2012","unstructured":"M\u00f3rotz, G. M., De Vos, K. J., Vagnoni, A., Ackerley, S., Shaw, C. E., & Miller, C. C. J. (2012). Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria. Human Molecular Genetics, 21, 1979\u20131988.","journal-title":"Human Molecular Genetics"},{"key":"8870_CR120","first-page":"347","volume":"2","author":"JR Morrice","year":"1863","unstructured":"Morrice, J. R., & Gregory-Evans, C. Y. (1863). Shaw CA (2017) Necroptosis in amyotrophic lateral sclerosis and other neurological disorders. Biochimica Et Biophysica Acta (BBA)-Molecular Basis of Disease, 2, 347\u2013353.","journal-title":"Biochimica Et Biophysica Acta (BBA)-Molecular Basis of Disease"},{"key":"8870_CR121","first-page":"227","volume":"23","author":"F Muller","year":"2000","unstructured":"Muller, F. (2000). The nature and mechanism of superoxide production by the electron transport chain: Its relevance to aging. Journal of the American Aging Association, 23, 227\u2013253.","journal-title":"Journal of the American Aging Association"},{"key":"8870_CR122","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1212\/01.WNL.0000134608.83927.B1","volume":"63","author":"C M\u00fcnch","year":"2004","unstructured":"M\u00fcnch, C., et al. (2004). Point mutations of the p150 subunit of dynactin (DCTN1) gene ALS. Neurology, 63, 724\u2013726.","journal-title":"Neurology"},{"key":"8870_CR123","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1111\/bph.12476","volume":"171","author":"H Muyderman","year":"2014","unstructured":"Muyderman, H., & Chen, T. (2014). Mitochondrial dysfunction in amyotrophic lateral sclerosis\u2014a valid pharmacological target? British Journal of Pharmacology, 171, 2191\u20132205.","journal-title":"British Journal of Pharmacology"},{"key":"8870_CR124","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13024-018-0271-7","volume":"13","author":"G Nardo","year":"2018","unstructured":"Nardo, G., Trolese, M. C., Verderio, M., et al. (2018). Counteracting roles of MHCI and CD8+ T cells in the peripheral and central nervous system of ALS SOD1G93A mice. Molecular Neurodegeneration, 13, 42.","journal-title":"Molecular Neurodegeneration"},{"issue":"1","key":"8870_CR125","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1111\/imr.13083","volume":"311","author":"DV Neel","year":"2022","unstructured":"Neel, D. V., Basu, H., Gunner, G., & Chiu, I. M. (2022). Catching a killer: Mechanisms of programmed cell death and immune activation in amyotrophic lateral sclerosis. Immunological Reviews, 311(1), 130\u2013150.","journal-title":"Immunological Reviews"},{"key":"8870_CR126","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1093\/oxfordjournals.aje.a010184","volume":"151","author":"LM Nelson","year":"2000","unstructured":"Nelson, L. M., Matkin, C., Longstreth, W. T. J., & McGuire, V. (2000). Population-based case-control study of amyotrophic lateral sclerosis in western Washington State. II. Diet. American Journal of Epidemiology, 151, 164\u2013173. https:\/\/doi.org\/10.1093\/oxfordjournals.aje.a010184","journal-title":"American Journal of Epidemiology"},{"key":"8870_CR127","first-page":"e33746","volume":"15","author":"P Neupane","year":"2023","unstructured":"Neupane, P., Thada, P. K., Singh, P., et al. (2023). Investigating edaravone use for management of amyotrophic lateral sclerosis (ALS): A narrative review. Cureus, 15, e33746.","journal-title":"Cureus"},{"key":"8870_CR128","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1080\/21678421.2020.1772825","volume":"21","author":"ST Ngo","year":"2020","unstructured":"Ngo, S. T., Restuadi, R., McCrae, A. F., Van Eijk, R. P., Garton, F., Henderson, R. D., et al. (2020). Progression and survival of patients with motor neuron disease relative to their fecal microbiota. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 21, 549\u2013562. https:\/\/doi.org\/10.1080\/21678421.2020.1772825","journal-title":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"},{"key":"8870_CR129","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.3390\/biomedicines9101324","volume":"9","author":"E Niccolai","year":"2021","unstructured":"Niccolai, E., Di Pilato, V., Nannini, G., Baldi, S., Russo, E., Zucchi, E., et al. (2021). The gut microbiota-immunity axis in ALS: A role in deciphering disease heterogeneity? Biomedicines, 9, 1324. https:\/\/doi.org\/10.3390\/biomedicines9101324","journal-title":"Biomedicines"},{"key":"8870_CR130","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1080\/21678421.2020.1828475","volume":"22","author":"K Nicholson","year":"2021","unstructured":"Nicholson, K., Bjornevik, K., Abu-Ali, G., Chan, J., Cortese, M., Dedi, B., Jeon, M., Xavier, R., Huttenhower, C., Ascherio, A., et al. (2021). The human gut microbiota in people with amyotrophic lateral sclerosis. Amyotroph Lateral Scler Front Degener, 22, 186\u2013194.","journal-title":"Amyotroph Lateral Scler Front Degener"},{"key":"8870_CR131","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1016\/j.neuron.2018.02.027","volume":"97","author":"A Nicolas","year":"2018","unstructured":"Nicolas, A., et al. (2018). Genome-wide analyses identify KIF5A as a novel ALS gene. Neuron, 97, 1268-1283.e6.","journal-title":"Neuron"},{"key":"8870_CR132","doi-asserted-by":"publisher","first-page":"175628642413098","DOI":"10.1177\/17562864241309811","volume":"18","author":"T Niu","year":"2025","unstructured":"Niu, T., Wang, P., Zhou, X., et al. (2025). An overlap-weighted analysis on the association of constipation symptoms with disease progression and survival in amyotrophic lateral sclerosis: A nested case-control study. Therapeutic Advances in Neurological Disorders, 18, 17562864241309812. https:\/\/doi.org\/10.1177\/17562864241309811","journal-title":"Therapeutic Advances in Neurological Disorders"},{"key":"8870_CR133","doi-asserted-by":"publisher","first-page":"590","DOI":"10.3390\/nu16050590","volume":"16","author":"A Noor Eddin","year":"2024","unstructured":"Noor Eddin, A., Alfuwais, M., Noor Eddin, R., Alkattan, K., & Yaqinuddin, A. (2024). Gut-modulating agents and amyotrophic lateral sclerosis: current evidence and future perspectives. Nutrients, 16, 590.","journal-title":"Nutrients"},{"key":"8870_CR134","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.neulet.2006.07.044","volume":"406","author":"YK Oh","year":"2006","unstructured":"Oh, Y. K., Shin, K. S., & Kang, S. J. (2006). AIF translocates to the nucleus in the spinal motor neurons in a mouse model of ALS. Neuroscience Letters, 406, 205\u2013210.","journal-title":"Neuroscience Letters"},{"key":"8870_CR135","doi-asserted-by":"publisher","first-page":"821","DOI":"10.3389\/fimmu.2023.1080027","volume":"14","author":"\u00c9J O'Reilly","year":"2023","unstructured":"O\u2019Reilly, \u00c9. J., Fitzgerald, K. C., Falcone, G. J., McCullough, M. L., Hart, J. E., Ascherio, A., & Weisskopf, M. G. (2023). Probiotic intake is inversely associated with amyotrophic lateral sclerosis in women. Frontiers in Immunology, 14, 821. https:\/\/doi.org\/10.3389\/fimmu.2023.1080027","journal-title":"Frontiers in Immunology"},{"key":"8870_CR136","doi-asserted-by":"publisher","first-page":"39","DOI":"10.4081\/ni.2015.5885","volume":"7","author":"M Orsini","year":"2015","unstructured":"Orsini, M., Oliveira, A. B., Nascimento, O. J., et al. (2015). Amyotrophic lateral sclerosis: New perspectives and update. Neurology International, 7, 39\u201347. https:\/\/doi.org\/10.4081\/ni.2015.5885","journal-title":"Neurology International"},{"key":"8870_CR137","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00429-023-02728-6","volume":"229","author":"SV Ovsepian","year":"2024","unstructured":"Ovsepian, S. V., O\u2019Leary, V. B., & Martinez, S. (2024). Selective vulnerability of motor neuron types and functional groups to degeneration in amyotrophic lateral sclerosis: Review of the neurobiological mechanisms and functional correlates. Brain Structure & Function, 229, 1\u201314. https:\/\/doi.org\/10.1007\/s00429-023-02728-6","journal-title":"Brain Structure & Function"},{"key":"8870_CR138","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1056\/NEJMoa1916945","volume":"383","author":"S Paganoni","year":"2020","unstructured":"Paganoni, S., et al. (2020). Trial of sodium phenylbutyrate\u2013taurursodiol for ALS. New England Journal of Medicine, 383, 919\u2013930.","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"8870_CR139","first-page":"2348","volume":"27","author":"MD Palomo Ruiz","year":"2023","unstructured":"Palomo Ruiz, M. D., et al. (2023). Nuclear factor-\u03baB in the pathogenesis and progression of amyotrophic lateral sclerosis. Journal of Cellular and Molecular Medicine, 27(4), 2348\u20132359.","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"8870_CR140","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1080\/19490976.2019.1638722","volume":"11","author":"A Parker","year":"2020","unstructured":"Parker, A., Fonseca, S., & Carding, S. R. (2020). Gut microbes and metabolites as modulators of blood\u2013brain barrier integrity and brain health. Gut Microbes, 11, 135\u2013157.","journal-title":"Gut Microbes"},{"key":"8870_CR141","doi-asserted-by":"publisher","first-page":"509","DOI":"10.3390\/diagnostics11030509","volume":"11","author":"E Parobkova","year":"2021","unstructured":"Parobkova, E., & Matej, R. (2021). Amyotrophic lateral sclerosis and frontotemporal lobar degenerations: Similarities in genetic background. Diagnostics, 11, 509.","journal-title":"Diagnostics"},{"issue":"1","key":"8870_CR142","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.neuron.2004.06.021","volume":"43","author":"P Pasinelli","year":"2004","unstructured":"Pasinelli, P., Belford, M. E., Lennon, N., et al. (2004). Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria. Neuron, 43(1), 19\u201330.","journal-title":"Neuron"},{"key":"8870_CR143","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.676621","volume":"12","author":"AP Passaro","year":"2021","unstructured":"Passaro, A. P., Lebos, A. L., Yao, Y., & Stice, S. L. (2021). Immune response in neurological pathology: Emerging role of central and peripheral immune crosstalk. Frontiers in Immunology, 12, Article 676621.","journal-title":"Frontiers in Immunology"},{"issue":"3","key":"8870_CR144","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.3390\/ijms24032272","volume":"24","author":"D Pathak","year":"2023","unstructured":"Pathak, D., & Sriram, K. (2023). Molecular mechanisms underlying neuroinflammation elicited by occupational injuries and toxicants. International Journal of Molecular Sciences, 24(3), 2272.","journal-title":"International Journal of Molecular Sciences"},{"key":"8870_CR145","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3390\/audiolres15030053","volume":"15","author":"M P\u00e9rez-Bonilla","year":"2025","unstructured":"P\u00e9rez-Bonilla, M., D\u00edaz Borrego, P., Mora-Ortiz, M., Fern\u00e1ndez-Baillo, R., Mu\u00f1oz-Alcaraz, M. N., Mayordomo-Riera, F. J., & Girela L\u00f3pez, E. (2025). Relationship between voice analysis and functional status in patients with amyotrophic lateral sclerosis. Audiology Research, 15, 53. https:\/\/doi.org\/10.3390\/audiolres15030053","journal-title":"Audiology Research"},{"key":"8870_CR146","doi-asserted-by":"publisher","first-page":"1345684","DOI":"10.3389\/fmicb.2024.1345684","volume":"15","author":"P Petakh","year":"2024","unstructured":"Petakh, P., Oksenych, V., Kamyshna, I., Boisak, I., Lyubomirskaya, K., & Kamyshnyi, O. (2024). Exploring the complex interplay: Gut microbiome, stress, and leptospirosis. Frontiers in Microbiology, 15, 1345684. https:\/\/doi.org\/10.3389\/fmicb.2024.1345684","journal-title":"Frontiers in Microbiology"},{"key":"8870_CR147","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3389\/fnmol.2019.00025","volume":"12","author":"A Prasad","year":"2019","unstructured":"Prasad, A., Bharathi, V., Sivalingam, V., Girdhar, A., & Patel, B. K. (2019). Molecular mechanisms of TDP-43 misfolding and pathology in amyotrophic lateral sclerosis. Frontiers in Molecular Neuroscience, 12, 25.","journal-title":"Frontiers in Molecular Neuroscience"},{"key":"8870_CR148","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1038\/nn.4065","volume":"18","author":"M Prudencio","year":"2015","unstructured":"Prudencio, M., Belzil, V. V., Batra, R., Ross, C. A., Gendron, T. F., Pregent, L. J., et al. (2015). Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS. Nature Neuroscience, 18, 1175\u20131182.","journal-title":"Nature Neuroscience"},{"key":"8870_CR149","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1080\/21678421.2017.1418002","volume":"19","author":"E Pupillo","year":"2018","unstructured":"Pupillo, E., Bianchi, E., Chi\u00f2, A., Casale, F., Zecca, C., Tortelli, R., et al. (2018b). Amyotrophic lateral sclerosis and food intake. Amyotroph Lateral Scler Frontotemporal Degener, 19, 267\u2013274. https:\/\/doi.org\/10.1080\/21678421.2017.1418002","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"8870_CR150","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1080\/21678421.2017.1386687","volume":"19","author":"E Pupillo","year":"2018","unstructured":"Pupillo, E., Poloni, M., Bianchi, E., et al. (2018a). Trauma and amyotrophic lateral sclerosis: A European population-based case\u2013control study from the EURALS consortium. Amyotroph Lateral Scler Frontotemporal Degener, 19, 118\u2013125.","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"8870_CR151","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1007\/s13311-015-0344-z","volume":"12","author":"LV Reddy","year":"2015","unstructured":"Reddy, L. V., & Miller, T. M. (2015). RNA-targeted therapeutics for ALS. Neurotherapeutics, 12, 424\u2013427.","journal-title":"Neurotherapeutics"},{"issue":"3","key":"8870_CR152","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.humimm.2021.01.017","volume":"82","author":"J Rodrigues Lima-Junior","year":"2021","unstructured":"Rodrigues Lima-Junior, J., Sulzer, D., Lindestam Arlehamn, C. S., & Sette, A. (2021). The role of immune-mediated alterations and disorders in ALS disease. Human Immunology, 82(3), 155\u2013161.","journal-title":"Human Immunology"},{"key":"8870_CR153","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.3390\/biomedicines11082267","volume":"11","author":"D Rojas-Valverde","year":"2023","unstructured":"Rojas-Valverde, D., Bonilla, D. A., G\u00f3mez-Miranda, L. M., Calleja-N\u00fa\u00f1ez, J. J., Arias, N., & Mart\u00ednez-Guardado, I. (2023). Examining the interaction between exercise, gut microbiota, and neurodegeneration: Future research directions. Biomedicines, 11, 2267. https:\/\/doi.org\/10.3390\/biomedicines11082267","journal-title":"Biomedicines"},{"key":"8870_CR154","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/braincomms\/fcab157","volume":"3","author":"L Rolfes","year":"2021","unstructured":"Rolfes, L., Schulte-Mecklenbeck, A., Schreiber, S., Vielhaber, S., Herty, M., Marten, A., et al. (2021). Amyotrophic lateral sclerosis patients show increased peripheral and intrathecal T-cell activation. Brain Commun, 3, 1\u201311. https:\/\/doi.org\/10.1093\/braincomms\/fcab157","journal-title":"Brain Commun"},{"key":"8870_CR155","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1053\/j.gastro.2017.12.013","volume":"154","author":"J Rowin","year":"2018","unstructured":"Rowin, J., & Lewis, J. D. (2018). Benefits and risks of combining fecal microbiota transplantation with immunomodulator therapy. Gastroenterology, 154, 1277\u20131280. https:\/\/doi.org\/10.1053\/j.gastro.2017.12.013","journal-title":"Gastroenterology"},{"key":"8870_CR156","doi-asserted-by":"publisher","first-page":"e13443","DOI":"10.14814\/phy2.13443","volume":"5","author":"Y Rowin Jx","year":"2017","unstructured":"Rowin Jx, Y., Jung, B., & Sun, J. (2017). Gut inflammation and dysbiosis in human motor neuron disease. Physics Reports, 5, e13443. https:\/\/doi.org\/10.14814\/phy2.13443","journal-title":"Physics Reports"},{"issue":"6","key":"8870_CR157","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","volume":"167","author":"TR Sampson","year":"2020","unstructured":"Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., et al. (2020). Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson\u2019s disease. Cell, 167(6), 1469-1480.e12.","journal-title":"Cell"},{"key":"8870_CR158","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.clim.2013.04.010","volume":"148","author":"M Saresella","year":"2013","unstructured":"Saresella, M., Piancone, F., Tortorella, P., Marventano, I., Gatti, A., Caputo, D., Lunetta, C., Corbo, M., Rovaris, M., & Clerici, M. (2013). T helper-17 activation dominates the immunologic milieu of both amyotrophic lateral sclerosis and progressive multiple sclerosis. Clinical Immunology, 148, 79\u201388.","journal-title":"Clinical Immunology"},{"key":"8870_CR159","doi-asserted-by":"publisher","first-page":"4149","DOI":"10.1038\/sj.emboj.7601840","volume":"26","author":"J Sasabe","year":"2007","unstructured":"Sasabe, J., Chiba, T., Yamada, M., Okamoto, K., Nishimoto, I., Matsuoka, M., & Aiso, S. (2007). D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis. EMBO Journal, 26, 4149\u20134159.","journal-title":"EMBO Journal"},{"key":"8870_CR160","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1007\/s00401-007-0299-1","volume":"114","author":"S Sasaki","year":"2007","unstructured":"Sasaki, S., Horie, Y., & Iwata, M. (2007). Mitochondrial alterations in dorsal root ganglion cells in sporadic amyotrophic lateral sclerosis. Acta Neuropathologica, 114, 633\u2013639.","journal-title":"Acta Neuropathologica"},{"key":"8870_CR161","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neulet.2015.05.005","volume":"598","author":"S Sasaki","year":"2015","unstructured":"Sasaki, S., Iguchi, Y., Katsuno, M., & Sobue, G. (2015). Alterations in the blood\u2013spinal cord barrier in TDP-43 conditional knockout mice. Neuroscience Letters, 598, 1\u20135.","journal-title":"Neuroscience Letters"},{"key":"8870_CR162","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1002\/mds.29161","volume":"37","author":"M Sawamura","year":"2022","unstructured":"Sawamura, M., Onoe, H., Tsukada, H., et al. (2022). Lewy body disease primate model with alpha-Synuclein propagation from the olfactory bulb. Movement Disorders, 37, 2033\u20132044.","journal-title":"Movement Disorders"},{"key":"8870_CR163","volume-title":"amyotrophic lateral sclerosis","author":"F Scamps","year":"2021","unstructured":"Scamps, F., Aimond, F., Hilaire, C., & Raoul, C. (2021). Synaptic transmission and motoneuron excitability defects in amyotrophic lateral sclerosis. In T. Araki (Ed.), amyotrophic lateral sclerosis. Brisbane, AU: Exon Publications."},{"key":"8870_CR164","doi-asserted-by":"publisher","first-page":"eadg3665","DOI":"10.1126\/scitranslmed.adg3665","volume":"16","author":"J Scekic-Zahirovic","year":"2024","unstructured":"Scekic-Zahirovic, J., Benetton, C., Brunet, A., Ye, X., Logunov, E., Douchamps, V., Megat, S., Andry, V., Kan, V. W. Y., Stuart-Lopez, G., et al. (2024). Cortical hyperexcitability in mouse models and patients with amyotrophic lateral sclerosis is linked to noradrenaline deficiency. Science Translational Medicine, 16, eadg3665.","journal-title":"Science Translational Medicine"},{"key":"8870_CR165","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jare.2021.09.005","volume":"38","author":"S Shandilya","year":"2021","unstructured":"Shandilya, S., Kumar, S., Kumar Jha, N., Kumar Kesari, K., & Ruokolainen, J. (2021). Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection. Journal of Advanced Research, 38, 223\u2013244.","journal-title":"Journal of Advanced Research"},{"issue":"Suppl 2","key":"8870_CR166","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1007\/BF03160574","volume":"244","author":"PJ Shaw","year":"1997","unstructured":"Shaw, P. J., & Ince, P. G. (1997). Glutamate, excitotoxicity and amyotrophic lateral sclerosis. Journal of Neurology, 244(Suppl 2), S3\u2013S14. https:\/\/doi.org\/10.1007\/BF03160574","journal-title":"Journal of Neurology"},{"key":"8870_CR167","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3109\/00207454.2010.537416","volume":"121","author":"M Shrivastava","year":"2011","unstructured":"Shrivastava, M., Vivekanandhan, S., Pati, U., Behari, M., & Das, T. K. (2011). Mitochondrial perturbance and execution of apoptosis in platelet mitochondria of patients with amyotrophic lateral sclerosis. International Journal of Neuroscience, 121, 149\u2013158.","journal-title":"International Journal of Neuroscience"},{"key":"8870_CR168","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/ana.410390210","volume":"39","author":"L Siklos","year":"1996","unstructured":"Siklos, L., Engelhardt, J., Harati, Y., Smith, R. G., Joo, F., & Appel, S. H. (1996). Ultrastructural evidence for altered calcium in motor nerve terminals in amyotrophic lateral sclerosis. Annals of Neurology, 39, 203\u2013216.","journal-title":"Annals of Neurology"},{"key":"8870_CR169","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3389\/fendo.2020.00025","volume":"11","author":"YP Silva","year":"2020","unstructured":"Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020). The role of short-chain fatty acids from gut microbiota in gut-brain communication. Frontiers in Endocrinology (Lausanne), 11, 25.","journal-title":"Frontiers in Endocrinology (Lausanne)"},{"key":"8870_CR170","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/glia.24082","volume":"70","author":"SG Sims","year":"2022","unstructured":"Sims, S. G., Cisney, R. N., Lipscomb, M. M., & Meares, G. P. (2022). The role of endoplasmic reticulum stress in astrocytes. Glia, 70, 5\u201319.","journal-title":"Glia"},{"key":"8870_CR171","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.3390\/molecules24081583","volume":"22","author":"A Singh","year":"2019","unstructured":"Singh, A., Kukreti, R., Saso, L., & Kukreti, S. (2019a). Oxidative stress: A key modulator in neurodegenerative diseases. Molecules, 22, 1583. https:\/\/doi.org\/10.3390\/molecules24081583","journal-title":"Molecules"},{"issue":"3","key":"8870_CR172","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/s41580-018-0089-8","volume":"20","author":"R Singh","year":"2019","unstructured":"Singh, R., Letai, A., & Sarosiek, K. (2019b). Regulation of apoptosis in health and disease: The balancing act of BCL-2 family proteins. Nature Reviews Molecular Cell Biology, 20(3), 175\u2013193.","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"8870_CR173","doi-asserted-by":"publisher","first-page":"3655","DOI":"10.1016\/j.celrep.2020.02.078","volume":"30","author":"JN Sleigh","year":"2020","unstructured":"Sleigh, J. N., Tosolini, A. P., Gordon, D., Devoy, A., Fratta, P., Fisher, E. M. C., et al. (2020). Mice carrying ALS mutant TDP-43, but not mutant FUS, display in vivo defects in axonal transport of signaling endosomes. Cell Reports, 30, 3655-3662.e2.","journal-title":"Cell Reports"},{"key":"8870_CR174","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3389\/fnmol.2019.00231","volume":"12","author":"AB Smith","year":"2019","unstructured":"Smith, A. B., & Johnson, C. D. (2019). Inflammatory mediators and RNA binding proteins in ALS: A link to microbial dysbiosis. Frontiers in Molecular Neuroscience, 12, 231.","journal-title":"Frontiers in Molecular Neuroscience"},{"key":"8870_CR175","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101790","volume":"83","author":"P Soares","year":"2023","unstructured":"Soares, P., Silva, C., Chavarria, D., Silva, F. S. G., Oliveira, P. J., & Borges, F. (2023). Drug discovery and amyotrophic lateral sclerosis: Emerging challenges and therapeutic opportunities. Ageing Research Reviews, 83, Article 101790.","journal-title":"Ageing Research Reviews"},{"key":"8870_CR176","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.neuroscience.2013.04.038","volume":"246","author":"L Song","year":"2013","unstructured":"Song, L., Gao, Y., Zhang, X., & Le, W. (2013). Galactooligosaccharide improves the animal survival and alleviates motor neuron death in SOD1G93A mouse model of amyotrophic lateral sclerosis. Neuroscience, 246, 281\u2013290. https:\/\/doi.org\/10.1016\/j.neuroscience.2013.04.038","journal-title":"Neuroscience"},{"key":"8870_CR177","volume-title":"Handbook of Neurotoxicity","author":"KA Staats","year":"2022","unstructured":"Staats, K. A., & Van Den Bosch, L. (2022). Excitotoxicity and amyotrophic lateral sclerosis. In R. M. Kostrzewa (Ed.), Handbook of Neurotoxicity. Berlin: Springer."},{"key":"8870_CR178","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.neuint.2016.06.011","volume":"99","author":"RM Stilling","year":"2016","unstructured":"Stilling, R. M., van de Wouw, M., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2016). The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis? Neurochemistry International, 99, 110\u2013132.","journal-title":"Neurochemistry International"},{"key":"8870_CR179","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2024.e00441","volume":"21","author":"J Sun","year":"2024","unstructured":"Sun, J., & Zhang, Y. (2024). Microbiome and micronutrient in ALS: From novel mechanisms to new treatments. Neurotherapeutics, 21, Article e00441.","journal-title":"Neurotherapeutics"},{"key":"8870_CR180","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1042\/CBI20100532","volume":"34","author":"B Szende","year":"2010","unstructured":"Szende, B., & Tyih\u00e1k, E. (2010). Effect of formaldehyde on cell proliferation and death. Cell Biology International, 34, 1273\u20131282. https:\/\/doi.org\/10.1042\/CBI20100532","journal-title":"Cell Biology International"},{"key":"8870_CR181","doi-asserted-by":"publisher","first-page":"12767","DOI":"10.3390\/ijms252312767","volume":"25","author":"M Tanaka","year":"2024","unstructured":"Tanaka, M., Szab\u00f3, \u00c1., & V\u00e9csei, L. (2024). Redefining roles: A paradigm shift in tryptophan-kynurenine metabolism for innovative clinical applications. International Journal of Molecular Sciences, 25, 12767.","journal-title":"International Journal of Molecular Sciences"},{"key":"8870_CR182","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nature20413","volume":"539","author":"JP Taylor","year":"2016","unstructured":"Taylor, J. P., Brown, R. H., & Cleveland, D. W. (2016). Decoding ALS: From genes to mechanism. Nature, 539, 197\u2013206.","journal-title":"Nature"},{"key":"8870_CR183","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.3389\/fimmu.2018.01017","volume":"9","author":"RP Toth","year":"2018","unstructured":"Toth, R. P., & Atkin, J. D. (2018). Dysfunction of optineurin in amyotrophic lateral sclerosis and glaucoma. Frontiers in Immunology, 9, 1017.","journal-title":"Frontiers in Immunology"},{"key":"8870_CR184","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.3390\/cells12091523","volume":"12","author":"L Tzeplaeff","year":"2023","unstructured":"Tzeplaeff, L., Wilfling, S., Requardt, M. V., & Herdick, M. (2023). Current state and future directions in the therapy of ALS. Cells, 12, 1523. https:\/\/doi.org\/10.3390\/cells12091523","journal-title":"Cells"},{"key":"8870_CR185","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3389\/fnins.2018.00185","volume":"12","author":"Y Vermeiren","year":"2018","unstructured":"Vermeiren, Y., Janssens, J., Van Dam, D., & De Deyn, P. P. (2018). Serotonergic dysfunction in amyotrophic lateral sclerosis and Parkinson\u2019s disease: Similar mechanisms, dissimilar outcomes. Frontiers in Neuroscience, 12, 185.","journal-title":"Frontiers in Neuroscience"},{"key":"8870_CR186","doi-asserted-by":"publisher","first-page":"105674","DOI":"10.1016\/j.nbd.2022.105674","volume":"161","author":"D Visini","year":"2023","unstructured":"Visini, D., et al. (2023). Biomarkers for clinical trials in amyotrophic lateral sclerosis: Ready for prime time? Neurobiology of Diseases, 161, 105674. https:\/\/doi.org\/10.1016\/j.nbd.2022.105674","journal-title":"Neurobiology of Diseases"},{"issue":"5","key":"8870_CR187","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14780","volume":"36","author":"G Vivacqua","year":"2024","unstructured":"Vivacqua, G., Mancinelli, R., Leone, S., Vaccaro, R., Garro, L., Carotti, S., Ceci, L., Onori, P., Pannarale, L., Franchitto, A., Gaudio, E., & Casini, A. (2024). Endoplasmic reticulum stress: A possible connection between intestinal inflammation and neurodegenerative disorders. Neurogastroenterology and Motility, 36(5), Article e14780.","journal-title":"Neurogastroenterology and Motility"},{"key":"8870_CR188","doi-asserted-by":"publisher","first-page":"8097","DOI":"10.1038\/s41598-018-26397-2","volume":"8","author":"MA Vogt","year":"2018","unstructured":"Vogt, M. A., Ehsaei, Z., Knuckles, P., Higginbottom, A., Helmbrecht, M. S., Kunath, T., Eggan, K., Williams, L. A., Shaw, P. J., Wurst, W., et al. (2018). TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons. Scientific Reports, 8, 8097. https:\/\/doi.org\/10.1038\/s41598-018-26397-2","journal-title":"Scientific Reports"},{"key":"8870_CR189","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41531-021-00218-2","volume":"7","author":"ZD Wallen","year":"2021","unstructured":"Wallen, Z. D., Stone, W. J., Factor, S. A., et al. (2021). Exploring human-genome gut-microbiome interaction in Parkinson\u2019s disease. Npj Parkinson\u2019s Disease, 7, 74.","journal-title":"Npj Parkinson's Disease"},{"key":"8870_CR190","doi-asserted-by":"publisher","first-page":"e2106504118","DOI":"10.1073\/pnas.2106504118","volume":"118","author":"C Wang","year":"2021","unstructured":"Wang, C., Lau, C. Y., Ma, F., & Zheng, C. (2021b). Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America, 118, e2106504118.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"Suppl 1","key":"8870_CR191","doi-asserted-by":"publisher","first-page":"S23","DOI":"10.1016\/j.jfma.2018.08.011","volume":"118","author":"JW Wang","year":"2019","unstructured":"Wang, J. W., Kuo, C. H., Kuo, F. C., Wang, Y. K., Hsu, W. H., Yu, F. J., Hu, H. M., & Hsu, P. I. (2019). Fecal microbiota transplantation: Review and update. Journal of the Formosan Medical Association, 118(Suppl 1), S23\u2013S31. https:\/\/doi.org\/10.1016\/j.jfma.2018.08.011","journal-title":"Journal of the Formosan Medical Association"},{"key":"8870_CR192","volume":"146","author":"Y Wang","year":"2021","unstructured":"Wang, Y., Zhang, L., Zhou, X., et al. (2021a). The impact of probiotics on ER stress in ALS models. Neurobiology of Diseases, 146, Article 105133.","journal-title":"Neurobiology of Diseases"},{"key":"8870_CR193","volume":"410","author":"S Wu","year":"2020","unstructured":"Wu, S., et al. (2020). Rifaximin improves survival in patients with amyotrophic lateral sclerosis. Journal of the Neurological Sciences, 410, Article 116642.","journal-title":"Journal of the Neurological Sciences"},{"key":"8870_CR194","doi-asserted-by":"publisher","first-page":"e12356","DOI":"10.14814\/phy2.12356","volume":"3","author":"S Wu","year":"2015","unstructured":"Wu, S., Yi, J., Zhang, Y. G., Zhou, J., & Sun, J. (2015). Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model. Physiological Reports, 3, e12356. https:\/\/doi.org\/10.14814\/phy2.12356","journal-title":"Physiological Reports"},{"key":"8870_CR195","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40035-025-00366-9","volume":"14","author":"Q Xie","year":"2025","unstructured":"Xie, Q., Li, K., Chen, Y., Zhang, Z., Wang, H., & Liu, F. (2025). Gene therapy breakthroughs in ALS: A beacon of hope for 20% of ALS patients. Translational Neurodegeneration, 14, 19. https:\/\/doi.org\/10.1186\/s40035-025-00366-9","journal-title":"Translational Neurodegeneration"},{"key":"8870_CR196","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3389\/fnmol.2020.00078","volume":"13","author":"YC Xue","year":"2020","unstructured":"Xue, Y. C., Ng, C. S., Xiang, P., Liu, H., Zhang, K., Mohamud, Y., & Luo, H. (2020). Dysregulation of RNA-binding proteins in amyotrophic lateral sclerosis. Frontiers in Molecular Neuroscience, 13, 78.","journal-title":"Frontiers in Molecular Neuroscience"},{"key":"8870_CR197","doi-asserted-by":"publisher","first-page":"1172197","DOI":"10.3389\/fnmol.2023.1172197","volume":"16","author":"X Yang","year":"2023","unstructured":"Yang, X., Ma, Z., Lian, P., Xu, Y., & Cao, X. (2023). Common mechanisms underlying axonal transport deficits in neurodegenerative diseases: A mini review. Frontiers in Molecular Neuroscience, 16, 1172197.","journal-title":"Frontiers in Molecular Neuroscience"},{"key":"8870_CR198","first-page":"1","volume":"3","author":"H Yasuda","year":"2020","unstructured":"Yasuda, H., Yamamoto, H., Hanamura, K., Mehruba, M., Kawamata, T., Morisaki, H., et al. (2020). PKN1 promotes synapse maturation by inhibiting mGluR-dependent silencing through neuronal glutamate transporter activation. Communcations Biology, 3, 1\u201316.","journal-title":"Communcations Biology"},{"key":"8870_CR199","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1097\/CM9.0000000000000344","volume":"132","author":"CD Zhai","year":"2019","unstructured":"Zhai, C. D., Zheng, J. J., An, B. C., Huang, H. F., & Tan, Z. C. (2019). Intestinal microbiota composition in patients with amyotrophic lateral sclerosis: Establishment of bacterial and archaeal communities analyses. Chinese Medical Journal (Engl), 132, 1815\u20131822. https:\/\/doi.org\/10.1097\/CM9.0000000000000344","journal-title":"Chinese Medical Journal (Engl)"},{"key":"8870_CR200","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1053\/j.gastro.2023.09.016","volume":"165","author":"F Zhang","year":"2023","unstructured":"Zhang, F., Huang, R., Cheng, C., Wu, K., Liu, H., Sun, X., & Li, Y. (2023). Modulation of gut microbiota by fecal microbiota transplantation mitigates ALS pathology. Gastroenterology, 165, 1762-1776.e22. https:\/\/doi.org\/10.1053\/j.gastro.2023.09.016","journal-title":"Gastroenterology"},{"key":"8870_CR201","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3988\/jcn.2020.16.1.90","volume":"16","author":"F Zhang","year":"2020","unstructured":"Zhang, F., Zhang, L., Jiang, J., Qi, H., Xu, M., & Yu, X. (2020b). Inulin-type fructans for intervention in amyotrophic lateral sclerosis: A randomized, double-blinded, placebo-controlled pilot trial. Journal of Clinical Neurology, 16, 90\u201396. https:\/\/doi.org\/10.3988\/jcn.2020.16.1.90","journal-title":"Journal of Clinical Neurology"},{"key":"8870_CR202","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12974-020-1715-x","volume":"17","author":"H Zhang","year":"2020","unstructured":"Zhang, H., et al. (2020a). Gut microbiota and its impact on neurodegenerative diseases: A focus on RNA processing in ALS. Journal of Neuroinflammation, 17, 45.","journal-title":"Journal of Neuroinflammation"},{"key":"8870_CR203","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12883-021-02538-2","volume":"22","author":"L Zhang","year":"2022","unstructured":"Zhang, L., Zhuang, Z., Zhang, G., Huang, T., & Fan, D. (2022). Assessment of bidirectional relationships between 98 genera of the human gut microbiota and amyotrophic lateral sclerosis: A 2-sample Mendelian randomization study. BMC Neurology, 22, 8. https:\/\/doi.org\/10.1186\/s12883-021-02538-2","journal-title":"BMC Neurology"},{"key":"8870_CR204","doi-asserted-by":"crossref","first-page":"745","DOI":"10.3389\/fnins.2018.00745","volume":"12","author":"X Zhang","year":"2018","unstructured":"Zhang, X., et al. (2018). Alterations in gut microbiota composition and its impact on RNA processing in amyotrophic lateral sclerosis. Frontiers in Neuroscience, 12, 745.","journal-title":"Frontiers in Neuroscience"},{"key":"8870_CR205","volume":"12","author":"X Zhang","year":"2021","unstructured":"Zhang, X., Li, J., Zhao, Q., et al. (2021b). Gut microbiota dysbiosis in ALS. Frontiers in Neurology, 12, Article 631613.","journal-title":"Frontiers in Neurology"},{"key":"8870_CR206","doi-asserted-by":"publisher","first-page":"6428","DOI":"10.1126\/science.aav2606","volume":"363","author":"YJ Zhang","year":"2019","unstructured":"Zhang, Y. J., Guo, L., Gonzales, P. K., Gendron, T. F., Wu, Y., Jansen-West, K., et al. (2019). Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly (PR) toxicity. Science, 363, 6428.","journal-title":"Science"},{"key":"8870_CR207","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2024.2363880","volume":"16","author":"Y Zhang","year":"2024","unstructured":"Zhang, Y., Xia, Y., & Sun, J. (2024). Probiotics and microbial metabolites maintain barrier and neuromuscular functions and clean protein aggregation to delay disease progression in TDP43 mutation mice. Gut Microbes, 16, 1.","journal-title":"Gut Microbes"},{"key":"8870_CR208","first-page":"735258","volume":"13","author":"Y Zhang","year":"2021","unstructured":"Zhang, Y., Zhou, Y., Luo, Y., Liu, J., & Hu, X. (2021a). The role of gut microbiota in amyotrophic lateral sclerosis: Mechanisms and therapeutic implications. Front Aging Neurosci, 13, 735258.","journal-title":"Front Aging Neurosci"},{"key":"8870_CR209","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.892518","volume":"14","author":"C Zhao","year":"2022","unstructured":"Zhao, C., Liao, Y., Rahaman, A., & Kumar, V. (2022b). Towards understanding the relationship between ER stress and unfolded protein response in amyotrophic lateral sclerosis. Frontiers in Aging Neuroscience, 14, Article 892518.","journal-title":"Frontiers in Aging Neuroscience"},{"key":"8870_CR210","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.3390\/cells11132049","volume":"11","author":"J Zhao","year":"2022","unstructured":"Zhao, J., Wang, X., Huo, Z., Chen, Y., Liu, J., Zhao, Z., et al. (2022a). The impact of mitochondrial dysfunction in amyotrophic lateral sclerosis. Cells, 11, 2049.","journal-title":"Cells"},{"issue":"3","key":"8870_CR211","first-page":"837","volume":"24","author":"Z Zhao","year":"2023","unstructured":"Zhao, Z., et al. (2023). Gut microbiota dysbiosis and neuroinflammation: bridging the pathogenesis of amyotrophic lateral sclerosis. International Journal of Molecular Sciences, 24(3), 837.","journal-title":"International Journal of Molecular Sciences"},{"key":"8870_CR212","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12974-020-1705-z","volume":"17","author":"S Zhu","year":"2020","unstructured":"Zhu, S., Jiang, Y., Xu, K., et al. (2020). The progress of gut microbiome research related to brain disorders. Journal of Neuroinflammation, 17, 25. https:\/\/doi.org\/10.1186\/s12974-020-1705-z","journal-title":"Journal of Neuroinflammation"},{"issue":"1","key":"8870_CR213","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00401-021-02315-1","volume":"142","author":"L Zondler","year":"2021","unstructured":"Zondler, L., M\u00fcller, K., Khalaji, S., et al. (2021). Peripheral monocytes are functionally altered and invade the CNS in ALS patients. Acta Neuropathologica, 142(1), 139\u2013154.","journal-title":"Acta Neuropathologica"}],"container-title":["NeuroMolecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-025-08870-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12017-025-08870-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-025-08870-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T16:02:28Z","timestamp":1767196948000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12017-025-08870-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,3]]},"references-count":213,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["8870"],"URL":"https:\/\/doi.org\/10.1007\/s12017-025-08870-0","relation":{},"ISSN":["1559-1174"],"issn-type":[{"value":"1559-1174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,3]]},"assertion":[{"value":"25 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"Ethical approval was not applicable for this study as it did not involve human participants, animal subjects, or clinical trials.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}],"article-number":"50"}}