{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:59:34Z","timestamp":1791917974386,"version":"4.3.4"},"reference-count":143,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuromol Med"],"DOI":"10.1007\/s12017-025-08879-5","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T09:22:07Z","timestamp":1757064127000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Engineering the Microbiome: a Novel Approach to Managing Autoimmune Diseases"],"prefix":"10.1007","volume":"27","author":[{"given":"Thabit Moath","family":"Omar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karar H.","family":"Alfarttoosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Sanghvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Roopashree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Kashyap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Krithiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waam Mohammed","family":"Taher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariem","family":"Alwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood Jasem","family":"Jawad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali M. Ali","family":"Al-Nuaimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"issue":"2","key":"8879_CR1","doi-asserted-by":"publisher","first-page":"8970","DOI":"10.24294\/ti8970","volume":"8","author":"M Afzal","year":"2024","unstructured":"Afzal, M., Sah, A. K., Agarwal, S., Tanzeel, A., Elshaikh, R. H., Alobeidli, F. A., et al. (2024). Advancements in the treatment of autoimmune diseases: Integrating artificial intelligence for personalized medicine. Trends in Immunotherapy, 8(2), 8970.","journal-title":"Trends in Immunotherapy"},{"key":"8879_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13099-019-0341-6","volume":"12","author":"MT Alam","year":"2020","unstructured":"Alam, M. T., Amos, G. C., Murphy, A. R., Murch, S., Wellington, E. M., & Arasaradnam, R. P. (2020). Microbial imbalance in inflammatory bowel disease patients at different taxonomic levels. Gut Pathogens, 12, 1\u20138.","journal-title":"Gut Pathogens"},{"issue":"6","key":"8879_CR3","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1093\/rheumatology\/kez452","volume":"59","author":"D Armstrong","year":"2020","unstructured":"Armstrong, D., Dregan, A., Ashworth, M., White, P., McGee, C., & de Lusignan, S. (2020). Influence of prior antibiotic use on risk of rheumatoid arthritis: Case control study in general practice. Rheumatology, 59(6), 1281\u20131287.","journal-title":"Rheumatology"},{"key":"8879_CR4","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-023-10166-3","author":"JJ Arriaga-Morales","year":"2023","unstructured":"Arriaga-Morales, J. J., Ordaz-Pichardo, C., Castro-Mu\u00f1oz, R., & Dur\u00e1n-P\u00e1ramo, E. (2023). Attenuation of hyperglycemia in diabetic rats assisted by immobilized probiotic in sodium alginate. Probiotics and Antimicrobial Proteins. https:\/\/doi.org\/10.1007\/s12602-023-10166-3","journal-title":"Probiotics and Antimicrobial Proteins"},{"issue":"1","key":"8879_CR5","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1146\/annurev-immunol-030409-101159","volume":"28","author":"FY Avci","year":"2009","unstructured":"Avci, F. Y., & Kasper, D. L. (2009). How bacterial carbohydrates influence the adaptive immune system. Annual Review of Immunology, 28(1), 107\u2013130.","journal-title":"Annual Review of Immunology"},{"issue":"10","key":"8879_CR6","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1136\/ard-2023-223929","volume":"82","author":"DF Azzouz","year":"2023","unstructured":"Azzouz, D. F., Chen, Z., Izmirly, P. M., Chen, L. A., Li, Z., Zhang, C., et al. (2023). Longitudinal gut microbiome analyses and blooms of pathogenic strains during lupus disease flares. Annals of the Rheumatic Diseases, 82(10), 1315\u20131327.","journal-title":"Annals of the Rheumatic Diseases"},{"key":"8879_CR7","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1016\/B978-0-12-809954-4.00065-7","volume-title":"Physiology of the gastrointestinal tract","author":"G Bamias","year":"2018","unstructured":"Bamias, G., Rivera-Nieves, J., & Grisham, M. B. (2018). Recruitment of Inflammatory and Immune Cells in the Gut. Physiology of the gastrointestinal tract (pp. 1579\u20131614). Elsevier."},{"issue":"9","key":"8879_CR8","doi-asserted-by":"publisher","first-page":"e3114","DOI":"10.1210\/clinem\/dgaa407","volume":"105","author":"R Biassoni","year":"2020","unstructured":"Biassoni, R., Di Marco, E., Squillario, M., Barla, A., Piccolo, G., Ugolotti, E., et al. (2020). Gut microbiota in T1DM-onset pediatric patients: Machine-learning algorithms to classify microorganisms as disease linked. The Journal of Clinical Endocrinology & Metabolism, 105(9), e3114\u2013e3126.","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"issue":"1","key":"8879_CR9","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1146\/annurev-bioeng-062117-121019","volume":"20","author":"JR Bober","year":"2018","unstructured":"Bober, J. R., Beisel, C. L., & Nair, N. U. (2018). Synthetic biology approaches to engineer probiotics and members of the human microbiota for biomedical applications. Annual Review of Biomedical Engineering, 20(1), 277\u2013300.","journal-title":"Annual Review of Biomedical Engineering"},{"key":"8879_CR10","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009759","author":"V Braniste","year":"2014","unstructured":"Braniste, V., Al-Asmakh, M., Kowal, C., Anuar, F., Abbaspour, A., T\u00f3th, M., et al. (2014). The gut microbiota influences blood-brain barrier permeability in mice. Science Translational Medicine. https:\/\/doi.org\/10.1126\/scitranslmed.3009759","journal-title":"Science Translational Medicine"},{"issue":"5","key":"8879_CR11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155082","volume":"11","author":"C Buerth","year":"2016","unstructured":"Buerth, C., Mausberg, A. K., Heininger, M. K., Hartung, H.-P., Kieseier, B. C., & Ernst, J. F. (2016). Oral tolerance induction in experimental autoimmune encephalomyelitis with Candida utilis expressing the immunogenic MOG35-55 peptide. PLoS ONE, 11(5), Article e0155082.","journal-title":"PLoS ONE"},{"issue":"2","key":"8879_CR12","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/s41591-018-0326-x","volume":"25","author":"CT Charlesworth","year":"2019","unstructured":"Charlesworth, C. T., Deshpande, P. S., Dever, D. P., Camarena, J., Lemgart, V. T., Cromer, M. K., et al. (2019). Identification of preexisting adaptive immunity to Cas9 proteins in humans. Nature Medicine, 25(2), 249\u2013254.","journal-title":"Nature Medicine"},{"issue":"6","key":"8879_CR13","doi-asserted-by":"publisher","first-page":"531","DOI":"10.7555\/JBR.38.20240009","volume":"38","author":"V Chasov","year":"2024","unstructured":"Chasov, V., Zmievskaya, E., Ganeeva, I., Gilyazova, E., Davletshin, D., Filimonova, M., et al. (2024). Systemic lupus erythematosus therapeutic strategy: From immunotherapy to gut microbiota modulation. Journal of Biomedical Research, 38(6), 531.","journal-title":"Journal of Biomedical Research"},{"key":"8879_CR14","first-page":"1993","volume-title":"The human microbiota and its therapeutic options","author":"Y Chen","year":"2024","unstructured":"Chen, Y., & Li, L. (2024). The human microbiota and its therapeutic options (pp. 1993\u20132005). Elsevier."},{"issue":"6658","key":"8879_CR15","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1126\/science.adf3974","volume":"381","author":"RM Cooper","year":"2023","unstructured":"Cooper, R. M., Wright, J. A., Ng, J. Q., Goyne, J. M., Suzuki, N., Lee, Y. K., et al. (2023). Engineered bacteria detect tumor DNA. Science, 381(6658), 682\u2013686.","journal-title":"Science"},{"key":"8879_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40168-017-0252-z","volume":"5","author":"JD Corr\u00eaa","year":"2017","unstructured":"Corr\u00eaa, J. D., Calderaro, D. C., Ferreira, G. A., Mendon\u00e7a, S. M. S., Fernandes, G. R., Xiao, E., et al. (2017). Subgingival microbiota dysbiosis in systemic lupus erythematosus: Association with periodontal status. Microbiome, 5, 1\u201313.","journal-title":"Microbiome"},{"key":"8879_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12876-021-01856-9","volume":"21","author":"JW Crothers","year":"2021","unstructured":"Crothers, J. W., Chu, N. D., Nguyen, L. T. T., Phillips, M., Collins, C., Fortner, K., et al. (2021). Daily, oral FMT for long-term maintenance therapy in ulcerative colitis: Results of a single-center, prospective, randomized pilot study. BMC Gastroenterology, 21, 1\u201316.","journal-title":"BMC Gastroenterology"},{"issue":"5","key":"8879_CR18","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.3892\/etm.2021.10757","volume":"22","author":"ZF Dai","year":"2021","unstructured":"Dai, Z. F., Ma, X. Y., Yang, R. L., Wang, H. C., Xu, D. D., Yang, J. N., et al. (2021). Intestinal flora alterations in patients with ulcerative colitis and their association with inflammation. Experimental and Therapeutic Medicine, 22(5), 1322.","journal-title":"Experimental and Therapeutic Medicine"},{"issue":"2","key":"8879_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009253","volume":"17","author":"L Deng","year":"2021","unstructured":"Deng, L., Wojciech, L., Gascoigne, N. R., Peng, G., & Tan, K. S. (2021). New insights into the interactions between Blastocystis, the gut microbiota, and host immunity. PLoS Pathogens, 17(2), Article e1009253.","journal-title":"PLoS Pathogens"},{"issue":"1","key":"8879_CR20","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1093\/rheumatology\/keac237","volume":"62","author":"VF Derksen","year":"2023","unstructured":"Derksen, V. F., Allaart, C. F., Van der Helm-Van Mil, A. H., Huizinga, T. W., Toes, R. E., & van der Woude, D. (2023). In rheumatoid arthritis patients, total IgA1 and IgA2 levels are elevated: Implications for the mucosal origin hypothesis. Rheumatology, 62(1), 407\u2013416.","journal-title":"Rheumatology"},{"key":"8879_CR21","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-024-05077-y","author":"G Ding","year":"2024","unstructured":"Ding, G., Yang, X., Li, Y., Wang, Y., Du, Y., Wang, M., et al. (2024). Gut microbiota regulates gut homeostasis, mucosal immunity and influences immune-related diseases. Molecular and Cellular Biochemistry. https:\/\/doi.org\/10.1007\/s11010-024-05077-y","journal-title":"Molecular and Cellular Biochemistry"},{"issue":"6","key":"8879_CR22","doi-asserted-by":"publisher","first-page":"2945","DOI":"10.3390\/ijms22062945","volume":"22","author":"G Esposito","year":"2021","unstructured":"Esposito, G., Pesce, M., Seguella, L., Lu, J., Corpetti, C., Del Re, A., et al. (2021). Engineered Lactobacillus paracasei producing palmitoylethanolamide (PEA) prevents colitis in mice. International Journal of Molecular Sciences, 22(6), 2945.","journal-title":"International Journal of Molecular Sciences"},{"issue":"3","key":"8879_CR23","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.immuni.2020.02.001","volume":"52","author":"TM Fenton","year":"2020","unstructured":"Fenton, T. M., J\u00f8rgensen, P. B., Niss, K., Rubin, S. J., M\u00f6rbe, U. M., Riis, L. B., et al. (2020). Immune profiling of human gut-associated lymphoid tissue identifies a role for isolated lymphoid follicles in priming of region-specific immunity. Immunity, 52(3), 557-570.e556.","journal-title":"Immunity"},{"issue":"3","key":"8879_CR24","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/jpen.1682","volume":"44","author":"Y Fu","year":"2020","unstructured":"Fu, Y., Moscoso, D. I., Porter, J., Krishnareddy, S., Abrams, J. A., Seres, D., et al. (2020). Relationship between dietary fiber intake and short-chain fatty acid\u2013producing bacteria during critical illness: A prospective cohort study. Journal of Parenteral and Enteral Nutrition, 44(3), 463\u2013471.","journal-title":"Journal of Parenteral and Enteral Nutrition"},{"issue":"6371","key":"8879_CR25","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1126\/science.aan4236","volume":"359","author":"V Gopalakrishnan","year":"2018","unstructured":"Gopalakrishnan, V., Spencer, C. N., Nezi, L., Reuben, A., Andrews, M. C., Karpinets, T. V., et al. (2018). Gut microbiome modulates response to anti\u2013PD-1 immunotherapy in melanoma patients. Science, 359(6371), 97\u2013103.","journal-title":"Science"},{"key":"8879_CR26","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.3389\/fimmu.2020.02054","volume":"11","author":"JA Grondin","year":"2020","unstructured":"Grondin, J. A., Kwon, Y. H., Far, P. M., Haq, S., & Khan, W. I. (2020). Mucins in intestinal mucosal defense and inflammation: Learning from clinical and experimental studies. Frontiers in Immunology, 11, 2054.","journal-title":"Frontiers in Immunology"},{"issue":"1","key":"8879_CR27","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s12967-023-03892-3","volume":"21","author":"J Guo","year":"2023","unstructured":"Guo, J., Cui, G., Huang, W., Zheng, Z., Li, T., Gao, G., et al. (2023). Alterations in the human oral microbiota in systemic lupus erythematosus. Journal of Translational Medicine, 21(1), 95.","journal-title":"Journal of Translational Medicine"},{"issue":"8","key":"8879_CR28","doi-asserted-by":"publisher","first-page":"3306","DOI":"10.1111\/dom.15658","volume":"26","author":"K Guo","year":"2024","unstructured":"Guo, K., Ye, J., Li, J., Huang, J., & Zhou, Z. (2024). Effects of gut microbiome on type 1 diabetes susceptibility and complications: A large-scale bidirectional Mendelian randomization and external validation study. Diabetes, Obesity and Metabolism, 26(8), 3306\u20133317.","journal-title":"Diabetes, Obesity and Metabolism"},{"issue":"8","key":"8879_CR29","doi-asserted-by":"publisher","first-page":"777","DOI":"10.3748\/wjg.v26.i8.777","volume":"26","author":"A Gupta","year":"2020","unstructured":"Gupta, A., Saha, S., & Khanna, S. (2020). Therapies to modulate gut microbiota: Past, present and future. World Journal of Gastroenterology, 26(8), 777.","journal-title":"World Journal of Gastroenterology"},{"issue":"4","key":"8879_CR30","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1136\/gut.2008.176131","volume":"59","author":"ZZ Hamady","year":"2010","unstructured":"Hamady, Z. Z., Scott, N., Farrar, M. D., Lodge, J. P. A., Holland, K. T., Whitehead, T., et al. (2010). Xylan-regulated delivery of human keratinocyte growth factor-2 to the inflamed colon by the human anaerobic commensal bacterium Bacteroides ovatus. Gut, 59(4), 461\u2013469.","journal-title":"Gut"},{"issue":"26","key":"8879_CR31","doi-asserted-by":"publisher","first-page":"8048","DOI":"10.1080\/10408398.2022.2054934","volume":"63","author":"B-L He","year":"2023","unstructured":"He, B.-L., Xiong, Y., Hu, T.-G., Zong, M.-H., & Wu, H. (2023). Bifidobacterium spp. as functional foods: A review of current status, challenges, and strategies. Critical Reviews in Food Science and Nutrition, 63(26), 8048\u20138065.","journal-title":"Critical Reviews in Food Science and Nutrition"},{"issue":"32","key":"8879_CR32","doi-asserted-by":"publisher","first-page":"15774","DOI":"10.1073\/pnas.1905421116","volume":"116","author":"C Hidalgo-Cantabrana","year":"2019","unstructured":"Hidalgo-Cantabrana, C., Goh, Y. J., Pan, M., Sanozky-Dawes, R., & Barrangou, R. (2019). Genome editing using the endogenous type I CRISPR-Cas system in Lactobacillus crispatus. Proceedings of the National Academy of Sciences of the United States of America, 116(32), 15774\u201315783.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"8879_CR33","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.mib.2017.05.015","volume":"37","author":"C Hidalgo-Cantabrana","year":"2017","unstructured":"Hidalgo-Cantabrana, C., O\u2019Flaherty, S., & Barrangou, R. (2017). CRISPR-based engineering of next-generation lactic acid bacteria. Current Opinion in Microbiology, 37, 79\u201387.","journal-title":"Current Opinion in Microbiology"},{"key":"8879_CR34","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S456173","author":"J Hong","year":"2024","unstructured":"Hong, J., Fu, T., Liu, W., Du, Y., Bu, J., Wei, G., et al. (2024). An Update on the role and potential molecules in relation to Ruminococcus gnavus in inflammatory bowel disease obesity and diabetes mellitus. Diabetes Metabolic Syndrome and Obesity. https:\/\/doi.org\/10.2147\/DMSO.S456173","journal-title":"Diabetes Metabolic Syndrome and Obesity"},{"issue":"9","key":"8879_CR35","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/nbt.2647","volume":"31","author":"PD Hsu","year":"2013","unstructured":"Hsu, P. D., Scott, D. A., Weinstein, J. A., Ran, F. A., Konermann, S., Agarwala, V., et al. (2013). DNA targeting specificity of RNA-guided Cas9 nucleases. Nature Biotechnology, 31(9), 827\u2013832.","journal-title":"Nature Biotechnology"},{"key":"8879_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.134785","volume":"278","author":"Y Hu","year":"2024","unstructured":"Hu, Y., Zhu, S., Ye, X., Wen, Z., Fu, H., Zhao, J., et al. (2024). Oral delivery of sodium alginate\/chitosan bilayer microgels loaded with Lactobacillus rhamnosus GG for targeted therapy of ulcerative colitis. International Journal of Biological Macromolecules, 278, Article 134785.","journal-title":"International Journal of Biological Macromolecules"},{"key":"8879_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122274","volume":"301","author":"Q-X Huang","year":"2023","unstructured":"Huang, Q.-X., Liang, J.-L., Yang, C.-H., Li, K., Niu, M.-T., Fan, J.-X., et al. (2023). Stimulation-responsive mucoadhesive probiotics for inflammatory bowel disease treatment by scavenging reactive oxygen species and regulating gut microbiota. Biomaterials, 301, Article 122274.","journal-title":"Biomaterials"},{"key":"8879_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13099-019-0332-7","volume":"11","author":"P Jamshidi","year":"2019","unstructured":"Jamshidi, P., Hasanzadeh, S., Tahvildari, A., Farsi, Y., Arbabi, M., Mota, J. F., et al. (2019). Is there any association between gut microbiota and type 1 diabetes? A systematic review. Gut Pathogens, 11, 1\u201310.","journal-title":"Gut Pathogens"},{"issue":"10","key":"8879_CR39","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/nri.2016.88","volume":"16","author":"ME Johansson","year":"2016","unstructured":"Johansson, M. E., & Hansson, G. C. (2016). Immunological aspects of intestinal mucus and mucins. Nature Reviews Immunology, 16(10), 639\u2013649.","journal-title":"Nature Reviews Immunology"},{"issue":"1","key":"8879_CR40","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1097\/MCG.0b013e31823711fd","volume":"46","author":"SJ Kallus","year":"2012","unstructured":"Kallus, S. J., & Brandt, L. J. (2012). The intestinal microbiota and obesity. Journal of Clinical Gastroenterology, 46(1), 16\u201324.","journal-title":"Journal of Clinical Gastroenterology"},{"issue":"1","key":"8879_CR41","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1021\/acssynbio.0c00466","volume":"10","author":"A Kan","year":"2020","unstructured":"Kan, A., Gelfat, I., Emani, S., Praveschotinunt, P., & Joshi, N. S. (2020). Plasmid vectors for in vivo selection-free use with the probiotic E. coli Nissle 1917. ACS Synthetic Biology, 10(1), 94\u2013106.","journal-title":"ACS Synthetic Biology"},{"key":"8879_CR42","doi-asserted-by":"publisher","DOI":"10.36877\/pmmb.a0000396","author":"S Kandasamy","year":"2023","unstructured":"Kandasamy, S., Letchumanan, V., Hong, K. W., Chua, K.-O., Ab Mutalib, N. S., Ng, A. L. O., et al. (2023). The role of human gut microbe Ruminococcus gnavus in inflammatory diseases. Progress in Microbes & Molecular Biology. https:\/\/doi.org\/10.36877\/pmmb.a0000396","journal-title":"Progress in Microbes & Molecular Biology"},{"issue":"1","key":"8879_CR43","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/s41575-020-0350-4","volume":"18","author":"A Khoruts","year":"2021","unstructured":"Khoruts, A., Staley, C., & Sadowsky, M. J. (2021). Faecal microbiota transplantation for Clostridioides difficile: Mechanisms and pharmacology. Nature Reviews Gastroenterology & Hepatology, 18(1), 67\u201380.","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"issue":"5","key":"8879_CR44","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1038\/s41423-020-00625-0","volume":"18","author":"CH Kim","year":"2021","unstructured":"Kim, C. H. (2021). Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids. Cellular and Molecular Immunology, 18(5), 1161\u20131171.","journal-title":"Cellular and Molecular Immunology"},{"key":"8879_CR45","doi-asserted-by":"publisher","DOI":"10.1007\/s40005-024-00708-4","author":"JS Kim","year":"2024","unstructured":"Kim, J. S., Kim, B. J., Lee, S. M., Choi, I. S., Park, J. H., Choi, H.-G., et al. (2024). Single-cell nanoencapsulation enables fabrication of probiotics-loaded hydrogel dressing with improved wound healing efficacy in vivo. Journal of Pharmaceutical Investigation. https:\/\/doi.org\/10.1007\/s40005-024-00708-4","journal-title":"Journal of Pharmaceutical Investigation"},{"issue":"1","key":"8879_CR46","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.1038\/s41467-020-15545-w","volume":"11","author":"SM Kim","year":"2020","unstructured":"Kim, S. M., DeFazio, J. R., Hyoju, S. K., Sangani, K., Keskey, R., Krezalek, M. A., et al. (2020). Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity. Nature Communications, 11(1), 2354.","journal-title":"Nature Communications"},{"key":"8879_CR47","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.imlet.2021.03.008","volume":"233","author":"K Kitamura","year":"2021","unstructured":"Kitamura, K., Sasaki, M., Matsumoto, M., Shionoya, H., & Iida, K. (2021). Protective effect of Bacteroides fragilis LPS on Escherichia coli LPS-induced inflammatory changes in human monocytic cells and in a rheumatoid arthritis mouse model. Immunology Letters, 233, 48\u201356.","journal-title":"Immunology Letters"},{"issue":"1","key":"8879_CR48","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13075-023-03013-x","volume":"25","author":"JH Koh","year":"2023","unstructured":"Koh, J. H., Lee, E. H., Cha, K. H., Pan, C.-H., Kim, D., & Kim, W.-U. (2023). Factors associated with the composition of the gut microbiome in patients with established rheumatoid arthritis and its value for predicting treatment responses. Arthritis Research & Therapy, 25(1), 32.","journal-title":"Arthritis Research & Therapy"},{"issue":"17","key":"8879_CR49","doi-asserted-by":"publisher","first-page":"2666","DOI":"10.3748\/wjg.v29.i17.2666","volume":"29","author":"P Lahtinen","year":"2023","unstructured":"Lahtinen, P., Jalanka, J., Mattila, E., Tillonen, J., Bergman, P., Satokari, R., et al. (2023). Fecal microbiota transplantation for the maintenance of remission in patients with ulcerative colitis: A randomized controlled trial. World Journal of Gastroenterology, 29(17), 2666.","journal-title":"World Journal of Gastroenterology"},{"key":"8879_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.bej.2021.107952","volume":"168","author":"Y-J Lan","year":"2021","unstructured":"Lan, Y.-J., Tan, S.-I., Cheng, S.-Y., Ting, W.-W., Xue, C., Lin, T.-H., et al. (2021). Development of Escherichia coli Nissle 1917 derivative by CRISPR\/Cas9 and application for gamma-aminobutyric acid (GABA) production in antibiotic-free system. Biochemical Engineering Journal, 168, Article 107952.","journal-title":"Biochemical Engineering Journal"},{"key":"8879_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/ar3848","volume":"14","author":"SC Law","year":"2012","unstructured":"Law, S. C., Street, S., Yu, C.-H.A., Capini, C., Ramnoruth, S., Nel, H. J., et al. (2012). T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles. Arthritis Research & Therapy, 14, 1\u201312.","journal-title":"Arthritis Research & Therapy"},{"issue":"1","key":"8879_CR52","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1038\/s41598-025-85334-2","volume":"15","author":"D Lee","year":"2025","unstructured":"Lee, D., Muir, P., Lundberg, S., Lundholm, A., Sandegren, L., & Koskiniemi, S. (2025). A CRISPR-Cas9 system protecting E. coli against acquisition of antibiotic resistance genes. Scientific Reports, 15(1), 1545.","journal-title":"Scientific Reports"},{"key":"8879_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122584","volume":"309","author":"M Li","year":"2024","unstructured":"Li, M., Liu, N., Zhu, J., Wu, Y., Niu, L., Liu, Y., et al. (2024a). Engineered probiotics with sustained release of interleukin-2 for the treatment of inflammatory bowel disease after oral delivery. Biomaterials, 309, Article 122584.","journal-title":"Biomaterials"},{"key":"8879_CR54","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02471","volume":"10","author":"Y Li","year":"2019","unstructured":"Li, Y., & Peng, N. (2019). Endogenous CRISPR-Cas system-based genome editing and antimicrobials: Review and prospects. Frontiers in Microbiology, 10, Article 2471.","journal-title":"Frontiers in Microbiology"},{"key":"8879_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2024.109956","volume":"153","author":"Y Li","year":"2024","unstructured":"Li, Y., Pei, Y., Shan, Z., Jiang, Y., Cui, S. W., He, Z., et al. (2024b). A pH-sensitive W\/O\/W emulsion-bound carboxymethyl chitosan-alginate hydrogel bead system through the Maillard reaction for probiotics intestine-targeted delivery. Food Hydrocolloids, 153, Article 109956.","journal-title":"Food Hydrocolloids"},{"issue":"4","key":"8879_CR56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035240","volume":"7","author":"HV Lin","year":"2012","unstructured":"Lin, H. V., Frassetto, A., Kowalik, E. J., Jr., Nawrocki, A. R., Lu, M. M., Kosinski, J. R., et al. (2012). Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLoS ONE, 7(4), Article e35240.","journal-title":"PLoS ONE"},{"issue":"7","key":"8879_CR57","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/1751-2980.12909","volume":"21","author":"H Liu","year":"2020","unstructured":"Liu, H., Hong, X. L., Sun, T. T., Huang, X. W., Wang, J. L., & Xiong, H. (2020). Fusobacterium nucleatum exacerbates colitis by damaging epithelial barriers and inducing aberrant inflammation. Journal of Digestive Diseases, 21(7), 385\u2013398.","journal-title":"Journal of Digestive Diseases"},{"key":"8879_CR58","doi-asserted-by":"publisher","DOI":"10.34133\/bdr.0017","volume":"5","author":"L Liu","year":"2023","unstructured":"Liu, L., Helal, S. E., & Peng, N. (2023). CRISPR-Cas-based engineering of probiotics. BioDesign Research, 5, Article 0017.","journal-title":"BioDesign Research"},{"issue":"20","key":"8879_CR59","doi-asserted-by":"publisher","first-page":"e00948","DOI":"10.1128\/AEM.00948-21","volume":"87","author":"L Liu","year":"2021","unstructured":"Liu, L., Yang, D., Zhang, Z., Liu, T., Hu, G., He, M., et al. (2021). High-efficiency genome editing based on endogenous CRISPR-Cas system enhances cell growth and lactic acid production in Pediococcus acidilactici. Applied and Environmental Microbiology, 87(20), e00948-e1921.","journal-title":"Applied and Environmental Microbiology"},{"key":"8879_CR60","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.intimp.2018.02.004","volume":"57","author":"M Liu","year":"2018","unstructured":"Liu, M., Li, S., Zhang, Q., Xu, Z., Wang, J., & Sun, H. (2018). Oral engineered Bifidobacterium longum expressing rhMnSOD to suppress experimental colitis. International Immunopharmacology, 57, 25\u201332.","journal-title":"International Immunopharmacology"},{"issue":"6","key":"8879_CR61","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.chom.2019.10.008","volume":"26","author":"S Liu","year":"2019","unstructured":"Liu, S., Rezende, R. M., Moreira, T. G., Tankou, S. K., Cox, L. M., Wu, M., et al. (2019). Oral administration of miR-30d from feces of MS patients suppresses MS-like symptoms in mice by expanding Akkermansia muciniphila. Cell Host & Microbe, 26(6), 779-794.e778.","journal-title":"Cell Host & Microbe"},{"issue":"7758","key":"8879_CR62","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/s41586-019-1237-9","volume":"569","author":"J Lloyd-Price","year":"2019","unstructured":"Lloyd-Price, J., Arze, C., Ananthakrishnan, A. N., Schirmer, M., Avila-Pacheco, J., Poon, T. W., et al. (2019). Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. Nature, 569(7758), 655\u2013662.","journal-title":"Nature"},{"issue":"13","key":"8879_CR63","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1158\/1078-0432.CCR-23-0118","volume":"29","author":"JJ Luke","year":"2023","unstructured":"Luke, J. J., Piha-Paul, S. A., Medina, T., Verschraegen, C. F., Varterasian, M., Brennan, A. M., et al. (2023). Phase I study of SYNB1891, an engineered E. coli nissle strain expressing STING agonist, with and without atezolizumab in advanced malignancies. Clinical Cancer Research, 29(13), 2435\u20132444.","journal-title":"Clinical Cancer Research"},{"key":"8879_CR64","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.938358","volume":"13","author":"S Luo","year":"2022","unstructured":"Luo, S., Yue, T., Liu, Z., Yang, D., Xu, M., Ding, Y., et al. (2022). Gut microbiome and metabolic activity in type 1 diabetes: An analysis based on the presence of GADA. Frontiers in Endocrinology, 13, Article 938358.","journal-title":"Frontiers in Endocrinology"},{"issue":"32","key":"8879_CR65","doi-asserted-by":"publisher","first-page":"4685","DOI":"10.1016\/S0264-410X(03)00522-X","volume":"21","author":"CB Maassen","year":"2003","unstructured":"Maassen, C. B., Laman, J. D., van Holten-Neelen, C., Hoogteijling, L., Groenewegen, L., Visser, L., et al. (2003). Reduced experimental autoimmune encephalomyelitis after intranasal and oral administration of recombinant lactobacilli expressing myelin antigens. Vaccine, 21(32), 4685\u20134693.","journal-title":"Vaccine"},{"issue":"20","key":"8879_CR66","doi-asserted-by":"publisher","first-page":"e01416","DOI":"10.1128\/AEM.01416-19","volume":"85","author":"A Maikova","year":"2019","unstructured":"Maikova, A., Kreis, V., Boutserin, A., Severinov, K., & Soutourina, O. (2019). Using an endogenous CRISPR-Cas system for genome editing in the human pathogen Clostridium difficile. Applied and Environmental Microbiology, 85(20), e01416-01419.","journal-title":"Applied and Environmental Microbiology"},{"issue":"6","key":"8879_CR67","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/mi.2011.41","volume":"4","author":"NJ Mantis","year":"2011","unstructured":"Mantis, N. J., Rol, N., & Corth\u00e9sy, B. (2011). Secretory IgA\u2019s complex roles in immunity and mucosal homeostasis in the gut. Mucosal Immunology, 4(6), 603\u2013611.","journal-title":"Mucosal Immunology"},{"key":"8879_CR68","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.imlet.2019.08.008","volume":"214","author":"R Mao","year":"2019","unstructured":"Mao, R., Chen, Y., Wu, Q., Zhang, T., Diao, E., Wu, D., et al. (2019). Oral delivery of single-chain insulin (SCI-59) analog by bacterium-like particles (BLPs) induces oral tolerance and prevents autoimmune diabetes in NOD mice. Immunology Letters, 214, 37\u201344.","journal-title":"Immunology Letters"},{"issue":"6371","key":"8879_CR69","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1126\/science.aao3290","volume":"359","author":"V Matson","year":"2018","unstructured":"Matson, V., Fessler, J., Bao, R., Chongsuwat, T., Zha, Y., Alegre, M.-L., et al. (2018). The commensal microbiome is associated with anti\u2013PD-1 efficacy in metastatic melanoma patients. Science, 359(6371), 104\u2013108.","journal-title":"Science"},{"key":"8879_CR70","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00373.x","author":"TS McCormick","year":"2010","unstructured":"McCormick, T. S., & Weinberg, A. (2010). Epithelial cell-derived antimicrobial peptides are multi-functional agents that bridge innate and adaptive immunity. Periodontology 2000. https:\/\/doi.org\/10.1111\/j.1600-0757.2010.00373.x","journal-title":"Periodontology 2000"},{"issue":"8","key":"8879_CR71","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1136\/gutjnl-2017-315732","volume":"67","author":"G Mithieux","year":"2018","unstructured":"Mithieux, G. (2018). Does Akkermansia muciniphila play a role in type 1 diabetes? Gut, 67(8), 1373\u20131374.","journal-title":"Gut"},{"issue":"9","key":"8879_CR72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137429","volume":"10","author":"S Miyake","year":"2015","unstructured":"Miyake, S., Kim, S., Suda, W., Oshima, K., Nakamura, M., Matsuoka, T., et al. (2015). Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species belonging to clostridia XIVa and IV clusters. PLoS ONE, 10(9), Article e0137429.","journal-title":"PLoS ONE"},{"issue":"1","key":"8879_CR73","doi-asserted-by":"publisher","first-page":"1926841","DOI":"10.1080\/19490976.2021.1926841","volume":"13","author":"P Mokhtari","year":"2021","unstructured":"Mokhtari, P., Metos, J., & Anandh Babu, P. V. (2021). Impact of type 1 diabetes on the composition and functional potential of gut microbiome in children and adolescents: Possible mechanisms, current knowledge, and challenges. Gut Microbes, 13(1), 1926841.","journal-title":"Gut Microbes"},{"issue":"1","key":"8879_CR74","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s13075-023-03118-3","volume":"25","author":"J Moon","year":"2023","unstructured":"Moon, J., Lee, A. R., Kim, H., Jhun, J., Lee, S.-Y., Choi, J. W., et al. (2023). Faecalibacterium prausnitzii alleviates inflammatory arthritis and regulates IL-17 production, short chain fatty acids, and the intestinal microbial flora in experimental mouse model for rheumatoid arthritis. Arthritis Research & Therapy, 25(1), 130.","journal-title":"Arthritis Research & Therapy"},{"issue":"2","key":"8879_CR75","first-page":"e00007","volume":"4","author":"I Myrbraten","year":"2019","unstructured":"Myrbraten, I., Wiull, K., Salehian, Z., Havarstein, L., Straume, D., & Kjos, M. (2019). CRISPR interference for rapid knockdown of essential cell cycle genes in Lactobacillus plantarum. M Sphere, 4(2), e00007-19.","journal-title":"M Sphere"},{"key":"8879_CR76","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.757718","volume":"11","author":"K Nie","year":"2021","unstructured":"Nie, K., Ma, K., Luo, W., Shen, Z., Yang, Z., Xiao, M., et al. (2021). Roseburia intestinalis: A beneficial gut organism from the discoveries in genus and species. Frontiers in Cellular and Infection Microbiology, 11, Article 757718.","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"issue":"7","key":"8879_CR77","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.3390\/microorganisms10071368","volume":"10","author":"E Nova","year":"2022","unstructured":"Nova, E., G\u00f3mez-Martinez, S., & Gonz\u00e1lez-Soltero, R. (2022). The influence of dietary factors on the gut microbiota. Microorganisms, 10(7), 1368.","journal-title":"Microorganisms"},{"issue":"5","key":"8879_CR78","doi-asserted-by":"publisher","first-page":"4624","DOI":"10.3390\/ijerph20054624","volume":"20","author":"A Ordo\u00f1ez-Rodriguez","year":"2023","unstructured":"Ordo\u00f1ez-Rodriguez, A., Roman, P., Rueda-Ruzafa, L., Campos-Rios, A., & Cardona, D. (2023). Changes in gut microbiota and multiple sclerosis: A systematic review. International Journal of Environmental Research and Public Health, 20(5), 4624.","journal-title":"International Journal of Environmental Research and Public Health"},{"issue":"5","key":"8879_CR79","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.cell.2014.08.006","volume":"158","author":"NW Palm","year":"2014","unstructured":"Palm, N. W., De Zoete, M. R., Cullen, T. W., Barry, N. A., Stefanowski, J., Hao, L., et al. (2014). Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Cell, 158(5), 1000\u20131010.","journal-title":"Cell"},{"issue":"30","key":"8879_CR80","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2205068119","volume":"119","author":"M Pan","year":"2022","unstructured":"Pan, M., Morovic, W., Hidalgo-Cantabrana, C., Roberts, A., Walden, K. K., Goh, Y. J., et al. (2022). Genomic and epigenetic landscapes drive CRISPR-based genome editing in Bifidobacterium. Proceedings of the National Academy of Sciences of the United States of America, 119(30), Article e2205068119.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"8879_CR81","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.124631","volume":"405","author":"G Pant","year":"2021","unstructured":"Pant, G., Garlapati, D., Agrawal, U., Prasuna, R. G., Mathimani, T., & Pugazhendhi, A. (2021). Biological approaches practised using genetically engineered microbes for a sustainable environment: A review. Journal of Hazardous Materials, 405, Article 124631.","journal-title":"Journal of Hazardous Materials"},{"issue":"3","key":"8879_CR82","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/nri.2015.17","volume":"16","author":"A Perez-Lopez","year":"2016","unstructured":"Perez-Lopez, A., Behnsen, J., Nuccio, S.-P., & Raffatellu, M. (2016). Mucosal immunity to pathogenic intestinal bacteria. Nature Reviews Immunology, 16(3), 135\u2013148.","journal-title":"Nature Reviews Immunology"},{"issue":"10","key":"8879_CR83","doi-asserted-by":"publisher","first-page":"5466","DOI":"10.3390\/ijms23105466","volume":"23","author":"M Pesce","year":"2022","unstructured":"Pesce, M., Seguella, L., Del Re, A., Lu, J., Palenca, I., Corpetti, C., et al. (2022). Next-generation probiotics for inflammatory bowel disease. International Journal of Molecular Sciences, 23(10), 5466.","journal-title":"International Journal of Molecular Sciences"},{"issue":"3","key":"8879_CR84","doi-asserted-by":"publisher","first-page":"707","DOI":"10.3390\/biomedicines11030707","volume":"11","author":"A Piccioni","year":"2023","unstructured":"Piccioni, A., Rosa, F., Mannucci, S., Manca, F., Merra, G., Chiloiro, S., et al. (2023). Gut microbiota, LADA, and type 1 diabetes mellitus: An evolving relationship. Biomedicines, 11(3), 707.","journal-title":"Biomedicines"},{"issue":"8","key":"8879_CR85","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/s41581-023-00720-1","volume":"19","author":"DS Pisetsky","year":"2023","unstructured":"Pisetsky, D. S. (2023). Pathogenesis of autoimmune disease. Nature Reviews Nephrology, 19(8), 509\u2013524.","journal-title":"Nature Reviews Nephrology"},{"issue":"4","key":"8879_CR86","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1053\/j.gastro.2019.11.294","volume":"158","author":"R Pittayanon","year":"2020","unstructured":"Pittayanon, R., Lau, J. T., Leontiadis, G. I., Tse, F., Yuan, Y., Surette, M., et al. (2020). Differences in gut microbiota in patients with vs without inflammatory bowel diseases: A systematic review. Gastroenterology, 158(4), 930\u2013946931.","journal-title":"Gastroenterology"},{"issue":"8","key":"8879_CR87","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1038\/s42255-021-00430-7","volume":"3","author":"MK Puurunen","year":"2021","unstructured":"Puurunen, M. K., Vockley, J., Searle, S. L., Sacharow, S. J., Phillips, J. A., III., Denney, W. S., et al. (2021). Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: A first-in-human phase 1\/2a study. Nature Metabolism, 3(8), 1125\u20131132.","journal-title":"Nature Metabolism"},{"issue":"12","key":"8879_CR88","doi-asserted-by":"publisher","first-page":"1801427","DOI":"10.1002\/mnfr.201801427","volume":"63","author":"C Ren","year":"2019","unstructured":"Ren, C., Dokter-Fokkens, J., Figueroa Lozano, S., Zhang, Q., de Haan, B. J., Zhang, H., et al. (2019). Fibroblasts impact goblet cell responses to lactic acid bacteria after exposure to inflammatory cytokines and mucus disruptors. Molecular Nutrition & Food Research, 63(12), 1801427.","journal-title":"Molecular Nutrition & Food Research"},{"key":"8879_CR89","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jaut.2012.07.012","volume":"40","author":"RM Rezende","year":"2013","unstructured":"Rezende, R. M., Oliveira, R. P., Medeiros, S. R., Gomes-Santos, A. C., Alves, A. C., Loli, F. G., et al. (2013). Hsp65-producing Lactococcus lactis prevents experimental autoimmune encephalomyelitis in mice by inducing CD4+ LAP+ regulatory T cells. Journal of Autoimmunity, 40, 45\u201357.","journal-title":"Journal of Autoimmunity"},{"issue":"8","key":"8879_CR90","doi-asserted-by":"publisher","first-page":"2876","DOI":"10.2337\/db13-1236","volume":"63","author":"S Robert","year":"2014","unstructured":"Robert, S., Gysemans, C., Takiishi, T., Korf, H., Spagnuolo, I., Sebastiani, G., et al. (2014). Oral delivery of glutamic acid decarboxylase (GAD)-65 and IL10 by Lactococcus lactis reverses diabetes in recent-onset NOD mice. Diabetes, 63(8), 2876\u20132887.","journal-title":"Diabetes"},{"issue":"1","key":"8879_CR91","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1093\/clinids\/12.1.20","volume":"12","author":"P Rosenkranz","year":"1990","unstructured":"Rosenkranz, P., Lederman, M. M., Gopalakrishna, K., & Ellner, J. J. (1990). Septic arthritis caused by Bacteroides fragilis. Reviews of Infectious Diseases, 12(1), 20\u201330.","journal-title":"Reviews of Infectious Diseases"},{"issue":"1","key":"8879_CR92","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/s41467-022-28163-5","volume":"13","author":"AG Rottinghaus","year":"2022","unstructured":"Rottinghaus, A. G., Ferreiro, A., Fishbein, S. R., Dantas, G., & Moon, T. S. (2022). Genetically stable CRISPR-based kill switches for engineered microbes. Nature Communications, 13(1), 672.","journal-title":"Nature Communications"},{"issue":"6371","key":"8879_CR93","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1126\/science.aan3706","volume":"359","author":"B Routy","year":"2018","unstructured":"Routy, B., Le Chatelier, E., Derosa, L., Duong, C. P., Alou, M. T., Daill\u00e8re, R., et al. (2018). Gut microbiome influences efficacy of PD-1\u2013based immunotherapy against epithelial tumors. Science, 359(6371), 91\u201397.","journal-title":"Science"},{"issue":"1","key":"8879_CR94","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/s41564-021-01014-7","volume":"7","author":"BE Rubin","year":"2022","unstructured":"Rubin, B. E., Diamond, S., Cress, B. F., Crits-Christoph, A., Lou, Y. C., Borges, A. L., et al. (2022). Species-and site-specific genome editing in complex bacterial communities. Nature Microbiology, 7(1), 34\u201347.","journal-title":"Nature Microbiology"},{"issue":"7975","key":"8879_CR95","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/s41586-023-06409-6","volume":"620","author":"LM Sanmarco","year":"2023","unstructured":"Sanmarco, L. M., Rone, J. M., Polonio, C. M., Fernandez Lahore, G., Giovannoni, F., Ferrara, K., et al. (2023). Lactate limits CNS autoimmunity by stabilizing HIF-1\u03b1 in dendritic cells. Nature, 620(7975), 881\u2013889.","journal-title":"Nature"},{"issue":"1","key":"8879_CR96","doi-asserted-by":"publisher","first-page":"2431643","DOI":"10.1080\/19490976.2024.2431643","volume":"16","author":"AB Shah","year":"2024","unstructured":"Shah, A. B., Baiseitova, A., Zahoor, M., Ahmad, I., Ikram, M., Bakhsh, A., et al. (2024). Probiotic significance of Lactobacillus strains: A comprehensive review on health impacts, research gaps, and future prospects. Gut Microbes, 16(1), 2431643.","journal-title":"Gut Microbes"},{"issue":"6","key":"8879_CR97","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1080\/19490976.2017.1349041","volume":"8","author":"SK Shahi","year":"2017","unstructured":"Shahi, S. K., Freedman, S. N., & Mangalam, A. K. (2017). Gut microbiome in multiple sclerosis: The players involved and the roles they play. Gut Microbes, 8(6), 607\u2013615.","journal-title":"Gut Microbes"},{"key":"8879_CR98","doi-asserted-by":"publisher","first-page":"387","DOI":"10.3389\/fcimb.2017.00387","volume":"7","author":"J-F Sicard","year":"2017","unstructured":"Sicard, J.-F., Le Bihan, G., Vogeleer, P., Jacques, M., & Harel, J. (2017). Interactions of intestinal bacteria with components of the intestinal mucus. Frontiers in Cellular and Infection Microbiology, 7, 387.","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"8879_CR99","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.897971","volume":"13","author":"GJ Silverman","year":"2022","unstructured":"Silverman, G. J., Deng, J., & Azzouz, D. F. (2022). Sex-dependent lupus Blautia (Ruminococcus) gnavus strain induction of zonulin-mediated intestinal permeability and autoimmunity. Frontiers in Immunology, 13, Article 897971.","journal-title":"Frontiers in Immunology"},{"issue":"10","key":"8879_CR100","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.2337\/db19-0211","volume":"68","author":"MH Sofi","year":"2019","unstructured":"Sofi, M. H., Johnson, B. M., Gudi, R. R., Jolly, A., Gaudreau, M.-C., & Vasu, C. (2019). Polysaccharide A-dependent opposing effects of mucosal and systemic exposures to human gut commensal Bacteroides fragilis in type 1 diabetes. Diabetes, 68(10), 1975\u20131989.","journal-title":"Diabetes"},{"issue":"22","key":"8879_CR101","doi-asserted-by":"publisher","first-page":"e01259","DOI":"10.1128\/AEM.01259-17","volume":"83","author":"X Song","year":"2017","unstructured":"Song, X., Huang, H., Xiong, Z., Ai, L., & Yang, S. (2017). CRISPR-Cas9D10A nickase-assisted genome editing in Lactobacillus casei. Applied and Environmental Microbiology, 83(22), e01259-e11217.","journal-title":"Applied and Environmental Microbiology"},{"key":"8879_CR102","doi-asserted-by":"publisher","first-page":"1177504","DOI":"10.3389\/fimmu.2023.1177504","volume":"14","author":"M Sun","year":"2023","unstructured":"Sun, M., Ju, J., Xu, H., & Wang, Y. (2023a). Intestinal fungi and antifungal secretory immunoglobulin A in Crohn\u2019s disease. Frontiers in Immunology, 14, 1177504.","journal-title":"Frontiers in Immunology"},{"issue":"15","key":"8879_CR103","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.3390\/nano13152185","volume":"13","author":"Q Sun","year":"2023","unstructured":"Sun, Q., Yin, S., He, Y., Cao, Y., & Jiang, C. (2023b). Biomaterials and encapsulation techniques for probiotics: Current status and future prospects in biomedical applications. Nanomaterials (Basel), 13(15), 2185.","journal-title":"Nanomaterials (Basel)"},{"issue":"42","key":"8879_CR104","doi-asserted-by":"publisher","first-page":"20969","DOI":"10.1073\/pnas.1906843116","volume":"116","author":"Y Tan","year":"2019","unstructured":"Tan, Y., Chu, A. H., Bao, S., Hoang, D. A., Kebede, F. T., Xiong, W., et al. (2019). Rationally engineered Staphylococcus aureus Cas9 nucleases with high genome-wide specificity. Proceedings of the National Academy of Sciences of the United States of America, 116(42), 20969\u201320976.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"706","key":"8879_CR105","doi-asserted-by":"publisher","first-page":"eabn4722","DOI":"10.1126\/scitranslmed.abn4722","volume":"15","author":"KN Thompson","year":"2023","unstructured":"Thompson, K. N., Bonham, K. S., Ilott, N. E., Britton, G. J., Colmenero, P., Bullers, S. J., et al. (2023). Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes. Science Translational Medicine, 15(706), eabn4722.","journal-title":"Science Translational Medicine"},{"issue":"9","key":"8879_CR106","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1177\/13524585231186899","volume":"29","author":"RW Titball","year":"2023","unstructured":"Titball, R. W., Lewis, N., & Nicholas, R. (2023). Is Clostridium perfringens epsilon toxin associated with multiple sclerosis? Multiple Sclerosis Journal, 29(9), 1057\u20131063.","journal-title":"Multiple Sclerosis Journal"},{"issue":"12","key":"8879_CR107","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1002\/acn3.51476","volume":"8","author":"H Tremlett","year":"2021","unstructured":"Tremlett, H., Zhu, F., Arnold, D., Bar-Or, A., Bernstein, C. N., Bonner, C., et al. (2021). The gut microbiota in pediatric multiple sclerosis and demyelinating syndromes. Annals of Clinical and Translational Neurology, 8(12), 2252\u20132269.","journal-title":"Annals of Clinical and Translational Neurology"},{"issue":"4","key":"8879_CR108","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/nbt0409-344","volume":"27","author":"MH Tsch\u00f6p","year":"2009","unstructured":"Tsch\u00f6p, M. H., Hugenholtz, P., & Karp, C. L. (2009). Getting to the core of the gut microbiome. Nature Biotechnology, 27(4), 344\u2013346.","journal-title":"Nature Biotechnology"},{"issue":"1","key":"8879_CR109","doi-asserted-by":"publisher","first-page":"2387794","DOI":"10.1080\/19490976.2024.2387794","volume":"16","author":"T-A Turner","year":"2024","unstructured":"Turner, T.-A., Lehman, P., Ghimire, S., Shahi, S. K., & Mangalam, A. (2024). Game of microbes: The battle within\u2013gut microbiota and multiple sclerosis. Gut Microbes, 16(1), 2387794.","journal-title":"Gut Microbes"},{"issue":"5","key":"8879_CR110","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1056\/NEJMoa1205037","volume":"368","author":"E Van Nood","year":"2013","unstructured":"Van Nood, E., Vrieze, A., Nieuwdorp, M., Fuentes, S., Zoetendal, E. G., de Vos, W. M., et al. (2013). Duodenal infusion of donor feces for recurrent Clostridium difficile. New England Journal of Medicine, 368(5), 407\u2013415.","journal-title":"New England Journal of Medicine"},{"issue":"10","key":"8879_CR111","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1080\/00365521.2020.1803396","volume":"55","author":"S Vatn","year":"2020","unstructured":"Vatn, S., Carstens, A., Kristoffersen, A. B., Bergemalm, D., Cas\u00e9n, C., Moen, A. E. F., et al. (2020). Faecal microbiota signatures of IBD and their relation to diagnosis, disease phenotype, inflammation, treatment escalation and anti-TNF response in a European Multicentre Study (IBD-Character). Scandinavian Journal of Gastroenterology, 55(10), 1146\u20131156.","journal-title":"Scandinavian Journal of Gastroenterology"},{"issue":"2","key":"8879_CR112","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/s41591-018-0204-6","volume":"25","author":"DL Wagner","year":"2019","unstructured":"Wagner, D. L., Amini, L., Wendering, D. J., Burkhardt, L.-M., Aky\u00fcz, L., Reinke, P., et al. (2019). High prevalence of Streptococcus pyogenes Cas9-reactive T cells within the adult human population. Nature Medicine, 25(2), 242\u2013248.","journal-title":"Nature Medicine"},{"key":"8879_CR113","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.802823","volume":"13","author":"J Wan","year":"2022","unstructured":"Wan, J., Zhang, Y., He, W., Tian, Z., Lin, J., Liu, Z., et al. (2022). Gut microbiota and metabolite changes in patients with ulcerative colitis and Clostridioides difficile infection. Frontiers in Microbiology, 13, Article 802823.","journal-title":"Frontiers in Microbiology"},{"issue":"21","key":"8879_CR114","doi-asserted-by":"publisher","first-page":"3518","DOI":"10.1080\/10408398.2020.1802695","volume":"61","author":"C Wang","year":"2021","unstructured":"Wang, C., Zhao, J., Zhang, H., Lee, Y.-K., Zhai, Q., & Chen, W. (2021a). Roles of intestinal bacteroides in human health and diseases. Critical Reviews in Food Science and Nutrition, 61(21), 3518\u20133536.","journal-title":"Critical Reviews in Food Science and Nutrition"},{"issue":"3","key":"8879_CR115","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10219","volume":"6","author":"L Wang","year":"2021","unstructured":"Wang, L., Liao, Y., Yang, R., Zhu, Z., Zhang, L., Wu, Z., et al. (2021b). An engineered probiotic secreting Sj16 ameliorates colitis via Ruminococcaceae\/butyrate\/retinoic acid axis. Bioengineering & Translational Medicine, 6(3), Article e10219.","journal-title":"Bioengineering & Translational Medicine"},{"issue":"4","key":"8879_CR116","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.3390\/pharmaceutics15041202","volume":"15","author":"Q Wang","year":"2023","unstructured":"Wang, Q., Guo, H., Mao, W., Qian, X., & Liu, Y. (2023a). The oral delivery system of modified GLP-1 by probiotics for T2DM. Pharmaceutics, 15(4), 1202.","journal-title":"Pharmaceutics"},{"key":"8879_CR117","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.3389\/fmicb.2017.01933","volume":"8","author":"R Wang","year":"2017","unstructured":"Wang, R., Li, L., Huang, Y., Huang, T., Tang, J., Xie, T., et al. (2017). Pathogenicity of human ST23 Streptococcus agalactiae to fish and genomic comparison of pathogenic and non-pathogenic isolates. Frontiers in Microbiology, 8, 1933.","journal-title":"Frontiers in Microbiology"},{"key":"8879_CR118","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.883747","volume":"13","author":"W Wang","year":"2022","unstructured":"Wang, W., Fan, Y., & Wang, X. (2022). Lactobacillus: Friend or foe for systemic lupus erythematosus? Frontiers in Immunology, 13, Article 883747.","journal-title":"Frontiers in Immunology"},{"issue":"11","key":"8879_CR119","doi-asserted-by":"publisher","first-page":"2303958","DOI":"10.1002\/adhm.202303958","volume":"13","author":"Y Wang","year":"2024","unstructured":"Wang, Y., Shi, Y., Peng, X., Li, T., Liang, C., Wang, W., et al. (2024). Biochemotaxis-oriented engineering bacteria expressing GLP-1 enhance diabetes therapy by regulating the balance of immune. Advanced Healthcare Materials, 13(11), 2303958.","journal-title":"Advanced Healthcare Materials"},{"issue":"2","key":"8879_CR120","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2211977120","volume":"120","author":"Y Wang","year":"2023","unstructured":"Wang, Y., Zhu, D., Ortiz-Velez, L. C., Perry, J. L., Pennington, M. W., Hyser, J. M., et al. (2023b). A bioengineered probiotic for the oral delivery of a peptide Kv1. 3 channel blocker to treat rheumatoid arthritis. Proceedings of the National Academy of Sciences, 120(2), Article e2211977120.","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"2","key":"8879_CR121","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1099\/jmm.0.000197","volume":"65","author":"P Wei","year":"2016","unstructured":"Wei, P., Yang, Y., Ding, Q., Li, X., Sun, H., Liu, Z., et al. (2016). Oral delivery of Bifidobacterium longum expressing \u03b1-melanocyte-stimulating hormone to combat ulcerative colitis. Journal of Medical Microbiology, 65(2), 160\u2013168.","journal-title":"Journal of Medical Microbiology"},{"issue":"7","key":"8879_CR122","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.29781","volume":"96","author":"Y Xing","year":"2024","unstructured":"Xing, Y., Liu, Y., Sha, S., Zhang, Y., Dou, Y., Liu, C., et al. (2024). Multikingdom characterization of gut microbiota in patients with rheumatoid arthritis and rheumatoid arthritis-associated interstitial lung disease. Journal of Medical Virology, 96(7), Article e29781.","journal-title":"Journal of Medical Virology"},{"issue":"1","key":"8879_CR123","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3168\/jds.2019-17346","volume":"103","author":"Z-Q Xiong","year":"2020","unstructured":"Xiong, Z.-Q., Wei, Y.-Y., Kong, L.-H., Song, X., Yi, H.-X., & Ai, L.-Z. (2020). An inducible CRISPR\/dCas9 gene repression system in Lactococcus lactis. Journal of Dairy Science, 103(1), 161\u2013165.","journal-title":"Journal of Dairy Science"},{"key":"8879_CR124","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.jconrel.2022.06.061","volume":"349","author":"C Xu","year":"2022","unstructured":"Xu, C., Ban, Q., Wang, W., Hou, J., & Jiang, Z. (2022a). Novel nano-encapsulated probiotic agents: Encapsulate materials, delivery, and encapsulation systems. Journal of Controlled Release, 349, 184\u2013205.","journal-title":"Journal of Controlled Release"},{"key":"8879_CR125","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.bioactmat.2024.01.011","volume":"35","author":"H Xu","year":"2024","unstructured":"Xu, H., Li, Y., Song, J., Zhou, L., Wu, K., Lu, X., et al. (2024). Highly active probiotic hydrogels matrixed on bacterial EPS accelerate wound healing via maintaining stable skin microbiota and reducing inflammation. Bioactive Materials, 35, 31\u201344.","journal-title":"Bioactive Materials"},{"issue":"3","key":"8879_CR126","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202207890","volume":"35","author":"J Xu","year":"2023","unstructured":"Xu, J., Xu, J., Shi, T., Zhang, Y., Chen, F., Yang, C., et al. (2023). Probiotic-inspired nanomedicine restores intestinal homeostasis in colitis by regulating redox balance, immune responses, and the gut microbiome. Advanced Materials, 35(3), Article 2207890.","journal-title":"Advanced Materials"},{"issue":"1","key":"8879_CR127","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13099-022-00499-9","volume":"14","author":"X Xu","year":"2022","unstructured":"Xu, X., Ocansey, D. K. W., Hang, S., Wang, B., Amoah, S., Yi, C., et al. (2022b). The gut metagenomics and metabolomics signature in patients with inflammatory bowel disease. Gut Pathogens, 14(1), 26.","journal-title":"Gut Pathogens"},{"key":"8879_CR128","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00060-22","author":"A Yadegar","year":"2024","unstructured":"Yadegar, A., Bar-Yoseph, H., Monaghan, T. M., Pakpour, S., Severino, A., Kuijper, E. J., et al. (2024). Fecal microbiota transplantation: Current challenges and future landscapes. Clinical Microbiology Reviews. https:\/\/doi.org\/10.1128\/cmr.00060-22","journal-title":"Clinical Microbiology Reviews"},{"key":"8879_CR129","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202400856","author":"X Yang","year":"2024","unstructured":"Yang, X., Che, T., Tian, S., Zhang, Y., Zheng, Y., Zhang, Y., et al. (2024). A living microecological hydrogel with microbiota remodelling and immune reinstatement for diabetic wound healing. Advanced Healthcare Materials. https:\/\/doi.org\/10.1002\/adhm.202400856","journal-title":"Advanced Healthcare Materials"},{"issue":"3","key":"8879_CR130","doi-asserted-by":"publisher","first-page":"4041","DOI":"10.1021\/acsnano.1c09681","volume":"16","author":"X Yang","year":"2022","unstructured":"Yang, X., Yang, J., Ye, Z., Zhang, G., Nie, W., Cheng, H., et al. (2022). Physiologically inspired mucin coated Escherichia coli Nissle 1917 enhances biotherapy by regulating the pathological microenvironment to improve intestinal colonization. ACS Nano, 16(3), 4041\u20134058.","journal-title":"ACS Nano"},{"issue":"10","key":"8879_CR131","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8101587","volume":"8","author":"JY Yoo","year":"2020","unstructured":"Yoo, J. Y., Groer, M., Dutra, S. V. O., Sarkar, A., & McSkimming, D. I. (2020). Gut microbiota and immune system interactions. Microorganisms, 8(10), Article 1587.","journal-title":"Microorganisms"},{"key":"8879_CR132","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1342098","volume":"15","author":"SY Yu","year":"2024","unstructured":"Yu, S. Y., Oh, B. S., Ryu, S. W., Bak, J. E., Heo, E. S., Moon, J. C., et al. (2024). Novel microbiota Mesosutterella faecium sp. nov. has a protective effect against inflammatory bowel disease. Frontiers in Microbiology, 15, Article 1342098.","journal-title":"Frontiers in Microbiology"},{"key":"8879_CR133","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S496991","author":"Y-X Yuan","year":"2024","unstructured":"Yuan, Y.-X., Feng, S.-R., Wu, A.-Y., Wu, W.-H., Tian, P., Chen, A.-Z., et al. (2024). Influence of TNF-\u03b1 inhibitors on gut microbiota and immune modulation in treating ankylosing spondylitis: Insights into therapeutic mechanisms and clinical implications. Journal of Inflammation Research. https:\/\/doi.org\/10.2147\/JIR.S496991","journal-title":"Journal of Inflammation Research"},{"issue":"11","key":"8879_CR134","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260384","volume":"16","author":"Z Zangeneh","year":"2021","unstructured":"Zangeneh, Z., Abdi-Ali, A., Khamooshian, K., Alvandi, A., & Abiri, R. (2021). Bacterial variation in the oral microbiota in multiple sclerosis patients. PLoS ONE, 16(11), Article e0260384.","journal-title":"PLoS ONE"},{"key":"8879_CR135","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.686501","volume":"12","author":"L Zhang","year":"2021","unstructured":"Zhang, L., Qing, P., Yang, H., Wu, Y., Liu, Y., & Luo, Y. (2021). Gut microbiome and metabolites in systemic lupus erythematosus: Link, mechanisms and intervention. Frontiers in Immunology, 12, Article 686501.","journal-title":"Frontiers in Immunology"},{"key":"8879_CR136","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S492651","author":"S Zhang","year":"2024","unstructured":"Zhang, S., Ma, J., Ma, Y., Yi, J., Wang, B., Wang, H., et al. (2024). Engineering probiotics for diabetes management: Advances, challenges, and future directions in translational microbiology. International Journal of Nanomedicine. https:\/\/doi.org\/10.2147\/IJN.S492651","journal-title":"International Journal of Nanomedicine"},{"issue":"7","key":"8879_CR137","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.3390\/nu15071566","volume":"15","author":"T Zhang","year":"2023","unstructured":"Zhang, T., Zhang, J., & Duan, L. (2023). The role of genetically engineered probiotics for treatment of inflammatory bowel disease: A systematic review. Nutrients, 15(7), 1566.","journal-title":"Nutrients"},{"issue":"9","key":"8879_CR138","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.molmed.2020.04.001","volume":"26","author":"X Zhang","year":"2020","unstructured":"Zhang, X., Zhao, L.-D., & Li, H. (2020). The gut microbiota: Emerging evidence in autoimmune diseases. Trends in Molecular Medicine, 26(9), 862\u2013873.","journal-title":"Trends in Molecular Medicine"},{"issue":"2","key":"8879_CR139","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/jgh.15222","volume":"36","author":"H Zhao","year":"2021","unstructured":"Zhao, H., Xu, H., Chen, S., He, J., Zhou, Y., & Nie, Y. (2021). Systematic review and meta-analysis of the role of Faecalibacterium prausnitzii alteration in inflammatory bowel disease. Journal of Gastroenterology and Hepatology, 36(2), 320\u2013328.","journal-title":"Journal of Gastroenterology and Hepatology"},{"issue":"1","key":"8879_CR140","first-page":"3936247","volume":"2020","author":"H Zhou","year":"2020","unstructured":"Zhou, H., Zhao, X., Sun, L., Liu, Y., Lv, Y., Gang, X., et al. (2020). Gut microbiota profile in patients with type 1 diabetes based on 16S rRNA gene sequencing: A systematic review. Disease Markers, 2020(1), 3936247.","journal-title":"Disease Markers"},{"issue":"19","key":"8879_CR141","doi-asserted-by":"publisher","first-page":"3467","DOI":"10.1016\/j.cell.2022.08.021","volume":"185","author":"X Zhou","year":"2022","unstructured":"Zhou, X., Baumann, R., Gao, X., Mendoza, M., Singh, S., Sand, I. K., et al. (2022). Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course. Cell, 185(19), 3467-3486.e3416.","journal-title":"Cell"},{"issue":"9","key":"8879_CR142","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/nrm.2016.80","volume":"17","author":"C Zihni","year":"2016","unstructured":"Zihni, C., Mills, C., Matter, K., & Balda, M. S. (2016). Tight junctions: From simple barriers to multifunctional molecular gates. Nature Reviews Molecular Cell Biology, 17(9), 564\u2013580.","journal-title":"Nature Reviews Molecular Cell Biology"},{"issue":"6","key":"8879_CR143","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.cell.2018.08.041","volume":"174","author":"N Zmora","year":"2018","unstructured":"Zmora, N., Zilberman-Schapira, G., Suez, J., Mor, U., Dori-Bachash, M., Bashiardes, S., et al. (2018). Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features. Cell, 174(6), 1388-1405.e1321.","journal-title":"Cell"}],"container-title":["NeuroMolecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-025-08879-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12017-025-08879-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-025-08879-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T16:02:32Z","timestamp":1767196952000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12017-025-08879-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,5]]},"references-count":143,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["8879"],"URL":"https:\/\/doi.org\/10.1007\/s12017-025-08879-5","relation":{},"ISSN":["1559-1174"],"issn-type":[{"value":"1559-1174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,5]]},"assertion":[{"value":"23 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}}],"article-number":"63"}}