{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:02:03Z","timestamp":1793422923595,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuromol Med"],"DOI":"10.1007\/s12017-025-08880-y","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T11:34:24Z","timestamp":1754652864000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["An Enigma of Brain Gasotransmitters: Hydrogen Sulfide and Depression"],"prefix":"10.1007","volume":"27","author":[{"given":"Antonello","family":"Pinna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Kistowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2632-1211","authenticated-orcid":false,"given":"Artur","family":"Pa\u0142asz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"issue":"1","key":"8880_CR1","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/s42003-023-05016-5","volume":"6","author":"MM Al-Owais","year":"2023","unstructured":"Al-Owais, M. M., Hettiarachchi, N. T., Dallas, M. L., Scragg, J. L., Lippiat, J. D., Holden, A. V., Steele, D. S., & Peers, C. (2023). Inhibition of the voltage-gated potassium channel Kv1.5 by hydrogen sulfide attenuates remodeling through S-nitrosylation-mediated signaling. Communications Biology, 6(1), 651. https:\/\/doi.org\/10.1038\/s42003-023-05016-5","journal-title":"Communications Biology"},{"key":"8880_CR2","doi-asserted-by":"publisher","first-page":"109668","DOI":"10.1016\/j.pnpbp.2019.109668","volume":"94","author":"M Amidfar","year":"2019","unstructured":"Amidfar, M., Woelfer, M., R\u00e9us, G. Z., Quevedo, J., Walter, M., & Kim, Y. K. (2019). The role of NMDA receptor in neurobiology and treatment of major depressive disorder: Evidence from translational research. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 94, 109668. https:\/\/doi.org\/10.1016\/j.pnpbp.2019.109668","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"issue":"7","key":"8880_CR3","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1021\/acschemneuro.5c00057","volume":"16","author":"MA Azzam","year":"2025","unstructured":"Azzam, M. A., ElMonier, A. A., Gad, E. S., & Abd-Elmawla, M. A. (2025). Interplay of endoplasmic reticulum stress, inflammation, apoptosis, and oxidative stress in corticosteroid-induced anxiety and depression: Exploring therapeutic potential of hydrogen sulfide and sertraline. ACS Chemical Neuroscience, 16(7), 1361\u20131376. https:\/\/doi.org\/10.1021\/acschemneuro.5c00057","journal-title":"ACS Chemical Neuroscience"},{"issue":"7","key":"8880_CR4","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.3390\/antiox10071074","volume":"10","author":"X Bai","year":"2021","unstructured":"Bai, X., Batall\u00e9, G., & Pol, O. (2021). The anxiolytic and antidepressant effects of Diallyl Disulfide and GYY4137 in animals with chronic neuropathic pain. Antioxidants (Basel, Switzerland), 10(7), 1074. https:\/\/doi.org\/10.3390\/antiox10071074","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"6","key":"8880_CR5","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.3390\/antiox12061179","volume":"12","author":"X Bai","year":"2023","unstructured":"Bai, X., Batall\u00e9, G., Mart\u00ednez-Martel, I., & Pol, O. (2023). Hydrogen sulfide interacting with cannabinoid 2 receptors during sciatic nerve injury-induced neuropathic pain. Antioxidants, 12(6), 1179. https:\/\/doi.org\/10.3390\/antiox12061179","journal-title":"Antioxidants"},{"issue":"8","key":"8880_CR6","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.3390\/biology12081092","volume":"12","author":"P Bao","year":"2023","unstructured":"Bao, P., Gong, Y., Wang, Y., Xu, M., Qian, Z., Ni, X., & Lu, J. (2023). Hydrogen sulfide prevents LPS-Induced depression-like behavior through the suppression of NLRP3 inflammasome and pyroptosis and the improvement of mitochondrial function in the hippocampus of mice. Biology, 12(8), 1092. https:\/\/doi.org\/10.3390\/biology12081092","journal-title":"Biology"},{"issue":"4","key":"8880_CR7","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1111\/fcp.12763","volume":"36","author":"V Baskin","year":"2022","unstructured":"Baskin, V., Eroglu, E., Harmanci, N., & Erol, K. (2022). Antinociceptive, anxiolytic, and depression-like effects of hydrogen sulfide, nitric oxide, and carbon monoxide in rats and the role of opioidergic and serotonergic systems in antinociceptive activity. Fundamental and Clinical Pharmacology, 36(4), 674\u2013686. https:\/\/doi.org\/10.1111\/fcp.12763","journal-title":"Fundamental and Clinical Pharmacology"},{"issue":"10","key":"8880_CR8","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.3390\/antiox10101632","volume":"10","author":"G Batall\u00e9","year":"2021","unstructured":"Batall\u00e9, G., Bai, X., Pouso-V\u00e1zquez, E., Roch, G., Rodr\u00edguez, L., & Pol, O. (2021). The recovery of cognitive and affective deficiencies linked with chronic osteoarthritis pain and implicated pathways by slow-releasing hydrogen sulfide treatment. Antioxidants (Basel, Switzerland), 10(10), 1632. https:\/\/doi.org\/10.3390\/antiox10101632","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"17","key":"8880_CR9","doi-asserted-by":"publisher","first-page":"6275","DOI":"10.1021\/jm901638j","volume":"53","author":"G Caliendo","year":"2010","unstructured":"Caliendo, G., Cirino, G., Santagada, V., & Wallace, J. L. (2010). Synthesis and biological effects of hydrogen sulfide (H2S): Development of H2S-releasing drugs as pharmaceuticals. Journal of Medicinal Chemistry, 53(17), 6275\u20136286. https:\/\/doi.org\/10.1021\/jm901638j","journal-title":"Journal of Medicinal Chemistry"},{"issue":"3","key":"8880_CR10","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1158\/1078-0432.CCR-16-1326","volume":"23","author":"N Chan","year":"2017","unstructured":"Chan, N., Willis, A., Kornhauser, N., Ward, M. M., Lee, S. B., Nackos, E., Seo, B. R., Chuang, E., Cigler, T., Moore, A., Donovan, D., Vallee Cobham, M., Fitzpatrick, V., Schneider, S., Wiener, A., Guillaume-Abraham, J., Aljom, E., Zelkowitz, R., Warren, J. D., \u2026 Vahdat, L. (2017). Influencing the tumor microenvironment: A phase II study of copper depletion using Tetrathiomolybdate in patients with breast cancer at high risk for recurrence and in preclinical models of lung metastases. Clinical Cancer Research: an Official Journal of the American Association for Cancer Research, 23(3), 666\u2013676. https:\/\/doi.org\/10.1158\/1078-0432.CCR-16-1326","journal-title":"Clinical Cancer Research: an Official Journal of the American Association for Cancer Research"},{"issue":"50","key":"8880_CR11","doi-asserted-by":"publisher","first-page":"52082","DOI":"10.1074\/jbc.C400481200","volume":"279","author":"X Chen","year":"2004","unstructured":"Chen, X., Jhee, K. H., & Kruger, W. D. (2004). Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine. The Journal of Biological Chemistry, 279(50), 52082\u201352086. https:\/\/doi.org\/10.1074\/jbc.C400481200","journal-title":"The Journal of Biological Chemistry"},{"issue":"3","key":"8880_CR12","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1097\/WNR.0000000000001870","volume":"34","author":"L Du","year":"2023","unstructured":"Du, L., Chen, L., Luo, B., Chen, Y. J., Zhang, P., Tang, Y. Y., Jiang, J. M., & Zou, W. (2023). Silent information regulator 1 mediates H2S-inhibited chronic restraint stress-induced depressive-like behaviors by regulating hippocampal autophagy. NeuroReport, 34(3), 128\u2013136. https:\/\/doi.org\/10.1097\/WNR.0000000000001870","journal-title":"NeuroReport"},{"issue":"3","key":"8880_CR13","doi-asserted-by":"publisher","first-page":"e56857","DOI":"10.7759\/cureus.56857","volume":"16","author":"SS Dutta","year":"2024","unstructured":"Dutta, S. S., Dasgupta, S., Banerjee, A. K., Nath, I., Biswas, U., Bera, N., & Ruram, A. (2024). Exploring the role of serum hydrogen sulphide (H2S) levels in manic depressive psychosis in terms of its association, diagnostic ability, and severity prediction: findings from a tertiary care center in North Bengal. Cureus, 16(3), e56857. https:\/\/doi.org\/10.7759\/cureus.56857","journal-title":"Cureus"},{"key":"8880_CR14","doi-asserted-by":"publisher","first-page":"1546737","DOI":"10.3389\/fpsyt.2025.1546737","volume":"16","author":"B Gu","year":"2025","unstructured":"Gu, B., Li, T., Zhao, H., Yue, R., Luo, Q., Yu, S., Li, T., Zhao, Y., Liu, D., Wang, Z., & Ho, C. S. H. (2025). Age-dependent effects of H2S on post-traumatic stress disorder in adolescent and adult mice. Frontiers in Psychiatry, 16, 1546737. https:\/\/doi.org\/10.3389\/fpsyt.2025.1546737","journal-title":"Frontiers in Psychiatry"},{"issue":"7","key":"8880_CR15","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1016\/j.pnpbp.2010.06.013","volume":"35","author":"K Hashimoto","year":"2011","unstructured":"Hashimoto, K. (2011). The role of glutamate on the action of antidepressants. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35(7), 1558\u20131568. https:\/\/doi.org\/10.1016\/j.pnpbp.2010.06.013","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"8880_CR16","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.neuroscience.2017.03.018","volume":"350","author":"J He","year":"2017","unstructured":"He, J., Guo, R., Qiu, P., Su, X., Yan, G., & Feng, J. (2017). Exogenous hydrogen sulfide eliminates spatial memory retrieval impairment and hippocampal CA1 LTD enhancement caused by acute stress via promoting glutamate uptake. Neuroscience, 350, 110\u2013123. https:\/\/doi.org\/10.1016\/j.neuroscience.2017.03.018","journal-title":"Neuroscience"},{"issue":"12","key":"8880_CR17","doi-asserted-by":"publisher","first-page":"10221","DOI":"10.3168\/jds.2024-25169","volume":"107","author":"SK Jain","year":"2024","unstructured":"Jain, S. K., Margret, J. J., Parsanathan, R., & Velusamy, T. (2024). Efficacy of l-cysteine in increasing circulatory hydrogen sulfide, nitrite, and 25-hydroxyvitamin D levels in Zucker diabetic fatty rats and in vitro treatment of hydrogen sulfide and nitrite in upregulating vitamin D hydroxylase genes in monocytes. Journal of Dairy Science, 107(12), 10221\u201310230. https:\/\/doi.org\/10.3168\/jds.2024-25169","journal-title":"Journal of Dairy Science"},{"key":"8880_CR18","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.neuro.2021.05.016","volume":"85","author":"W Jiang","year":"2021","unstructured":"Jiang, W., Tang, Y. Y., Zhu, W. W., Li, C., Zhang, P., Li, R. Q., Chen, Y. J., Zou, W., & Tang, X. Q. (2021). PI3K\/AKT pathway mediates the antidepressant- and anxiolytic-like roles of hydrogen sulfide in streptozotocin-induced diabetic rats via promoting hippocampal neurogenesis. Neurotoxicology, 85, 201\u2013208. https:\/\/doi.org\/10.1016\/j.neuro.2021.05.016","journal-title":"Neurotoxicology"},{"key":"8880_CR19","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.brainresbull.2021.10.002","volume":"177","author":"X Kang","year":"2021","unstructured":"Kang, X., Jiang, L., Lan, F., Tang, Y. Y., Zhang, P., Zou, W., Chen, Y. J., & Tang, X. Q. (2021). Hydrogen sulfide antagonizes sleep deprivation-induced depression- and anxiety-like behaviors by inhibiting neuroinflammation in a hippocampal Sirt1-dependent manner. Brain Research Bulletin, 177, 194\u2013202. https:\/\/doi.org\/10.1016\/j.brainresbull.2021.10.002","journal-title":"Brain Research Bulletin"},{"issue":"22","key":"8880_CR20","doi-asserted-by":"publisher","first-page":"5031","DOI":"10.1111\/bph.15246","volume":"177","author":"H Kimura","year":"2020","unstructured":"Kimura, H. (2020). Hydrogen sulfide signalling in the CNS - Comparison with NO. British Journal of Pharmacology, 177(22), 5031\u20135045. https:\/\/doi.org\/10.1111\/bph.15246","journal-title":"British Journal of Pharmacology"},{"issue":"6","key":"8880_CR21","doi-asserted-by":"publisher","first-page":"896","DOI":"10.3390\/biom11060896","volume":"11","author":"H Kimura","year":"2021","unstructured":"Kimura, H. (2021). Hydrogen sulfide (H2S) and polysulfide (H2Sn) signaling: The first 25 years. Biomolecules, 11(6), 896. https:\/\/doi.org\/10.3390\/biom11060896","journal-title":"Biomolecules"},{"key":"8880_CR22","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.niox.2013.07.002","volume":"35","author":"GK Kolluru","year":"2013","unstructured":"Kolluru, G. K., Shen, X., Bir, S. C., & Kevil, C. G. (2013). Hydrogen sulfide chemical biology: Pathophysiological roles and detection. Nitric Oxide, 35, 5\u201320. https:\/\/doi.org\/10.1016\/j.niox.2013.07.002","journal-title":"Nitric Oxide"},{"key":"8880_CR23","doi-asserted-by":"publisher","first-page":"107418","DOI":"10.1016\/j.psyneuen.2025.107418","volume":"175","author":"Z Ling","year":"2025","unstructured":"Ling, Z., Kong, Q., He, Z., Hao, X., Liu, R., Liu, J., Wang, Y., Liu, J., Du, W., & Liu, Y. (2025). Hydrogen sulfide improves depression-like behaviors in CUMS-induced mice by regulating autophagy. Psychoneuroendocrinology, 175, 107418. https:\/\/doi.org\/10.1016\/j.psyneuen.2025.107418","journal-title":"Psychoneuroendocrinology"},{"key":"8880_CR24","doi-asserted-by":"publisher","first-page":"173677","DOI":"10.1016\/j.pbb.2023.173677","volume":"234","author":"F Liu","year":"2024","unstructured":"Liu, F., Tian, Q., Tang, H. L., Cheng, X., Zou, W., & Zhang, P. (2024). Hydrogen sulfide attenuates depression-like behaviours in Parkinson\u2019s disease model rats by improving synaptic plasticity in a hippocampal Warburg effect-dependent manner. Pharmacology, Biochemistry, and Behavior, 234, 173677. https:\/\/doi.org\/10.1016\/j.pbb.2023.173677","journal-title":"Pharmacology, Biochemistry, and Behavior"},{"issue":"6","key":"8880_CR25","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1097\/WNR.0000000000002152","volume":"36","author":"B Luo","year":"2025","unstructured":"Luo, B., Xie, Y., Kuang, W., Wang, Y., Chen, G., Zhang, Y., & Yuan, M. (2025). Hydrogen sulfide improves poststroke depression-induced inflammation in microglial cells by enhancing endoplasmic reticulum autophagy and inhibiting the cGAS-STING pathway. NeuroReport, 36(6), 314\u2013326. https:\/\/doi.org\/10.1097\/WNR.0000000000002152","journal-title":"NeuroReport"},{"key":"8880_CR26","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.niox.2024.02.001","volume":"145","author":"JZ Lv","year":"2024","unstructured":"Lv, J. Z., Du, X. Z., Wu, Q., Gao, Y., Zhao, W., Wang, X., Li, Y., Li, J. X., Cao, X., Li, X., Xu, Y., Zhang, Y., Ren, Z. Y., & Liu, S. (2024). Plasma levels of hydrogen sulfide and homocysteine correlate with the efficacy of antidepressant agents and serve as potential diagnostic and therapeutic markers. Nitric Oxide, 145, 33\u201340. https:\/\/doi.org\/10.1016\/j.niox.2024.02.001","journal-title":"Nitric Oxide"},{"issue":"22","key":"8880_CR27","doi-asserted-by":"publisher","first-page":"e202502588","DOI":"10.1002\/anie.202502588","volume":"64","author":"T Ma","year":"2025","unstructured":"Ma, T., Gan, G., Cheng, J., Shen, Z., Zhang, G., Liu, S., & Hu, J. (2025). Engineered probiotics enable targeted gut delivery of dual gasotransmitters for inflammatory bowel disease therapy. Angewandte Chemie (International Ed. in English), 64(22), e202502588. https:\/\/doi.org\/10.1002\/anie.202502588","journal-title":"Angewandte Chemie (International Ed. in English)"},{"issue":"11","key":"8880_CR28","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.3390\/ph17111480","volume":"17","author":"C Munteanu","year":"2024","unstructured":"Munteanu, C., Onose, G., Po\u0219taru, M., Turnea, M., Rotariu, M., & Galaction, A. I. (2024). Hydrogen sulfide and gut microbiota: Their synergistic role in modulating sirtuin activity and potential therapeutic implications for neurodegenerative diseases. Pharmaceuticals, 17(11), 1480. https:\/\/doi.org\/10.3390\/ph17111480","journal-title":"Pharmaceuticals"},{"issue":"7","key":"8880_CR29","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/nrd.2017.16","volume":"16","author":"JW Murrough","year":"2017","unstructured":"Murrough, J. W., Abdallah, C. G., & Mathew, S. J. (2017). Targeting glutamate signalling in depression: Progress and prospects. Nature Reviews. Drug Discovery, 16(7), 472\u2013486. https:\/\/doi.org\/10.1038\/nrd.2017.16","journal-title":"Nature Reviews. Drug Discovery"},{"issue":"1\u20132","key":"8880_CR30","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/0006-8993(95)00057-w","volume":"675","author":"G Nowak","year":"1995","unstructured":"Nowak, G., Ordway, G. A., & Paul, I. A. (1995). Alterations in the N-methyl-D-aspartate (NMDA) receptor complex in the frontal cortex of suicide victims. Brain Research, 675(1\u20132), 157\u2013164. https:\/\/doi.org\/10.1016\/0006-8993(95)00057-w","journal-title":"Brain Research"},{"key":"8880_CR31","doi-asserted-by":"publisher","first-page":"244","DOI":"10.3389\/fnmol.2017.00244","volume":"10","author":"A Pacheco","year":"2017","unstructured":"Pacheco, A., Aguayo, F. I., Aliaga, E., Mu\u00f1oz, M., Garc\u00eda-Rojo, G., Olave, F. A., Parra-Fiedler, N. A., Garc\u00eda-P\u00e9rez, A., Tejos-Bravo, M., Rojas, P. S., Parra, C. S., & Fiedler, J. L. (2017). Chronic stress triggers expression of immediate early genes and differentially affects the expression of AMPA and NMDA subunits in dorsal and ventral hippocampus of rats. Frontiers in Molecular Neuroscience, 10, 244. https:\/\/doi.org\/10.3389\/fnmol.2017.00244","journal-title":"Frontiers in Molecular Neuroscience"},{"issue":"2","key":"8880_CR32","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s43440-021-00242-2","volume":"73","author":"A Pa\u0142asz","year":"2021","unstructured":"Pa\u0142asz, A., Menezes, I. C., & Worthington, J. J. (2021). The role of brain gaseous neurotransmitters in anxiety. Pharmacological Reports\u202f: PR, 73(2), 357\u2013371. https:\/\/doi.org\/10.1007\/s43440-021-00242-2","journal-title":"Pharmacological Reports : PR"},{"key":"8880_CR33","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.niox.2025.04.004","volume":"157","author":"V Pandey","year":"2025","unstructured":"Pandey, V., & Pandey, T. (2025). Hydrogen sulfide detection: Recent advancement and future perspectives towards fluorescence as a versatile biophysical method. Nitric Oxide: Biology and Chemistry, 157, 34\u201345. https:\/\/doi.org\/10.1016\/j.niox.2025.04.004","journal-title":"Nitric Oxide: Biology and Chemistry"},{"issue":"4","key":"8880_CR34","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1111\/1755-5922.12128","volume":"33","author":"DJ Polhemus","year":"2015","unstructured":"Polhemus, D. J., Li, Z., Pattillo, C. B., Gojon, G., Sr., Gojon, G., Jr., Giordano, T., & Krum, H. (2015). A novel hydrogen sulfide prodrug, SG1002, promotes hydrogen sulfide and nitric oxide bioavailability in heart failure patients. Cardiovascular Therapeutics, 33(4), 216\u2013226. https:\/\/doi.org\/10.1111\/1755-5922.12128","journal-title":"Cardiovascular Therapeutics"},{"issue":"1","key":"8880_CR35","doi-asserted-by":"publisher","first-page":"2874","DOI":"10.1038\/s41598-025-86885-0","volume":"15","author":"MM Qi","year":"2025","unstructured":"Qi, M. M., Peng, H. Y., Zhang, T. G., Li, Y., Gao, M. Y., Sun, W. B., & Wang, X. P. (2025). NaHS modulates astrocytic EAAT2 expression to impact SNI-induced neuropathic pain and depressive-like behaviors. Scientific Reports, 15(1), 2874. https:\/\/doi.org\/10.1038\/s41598-025-86885-0","journal-title":"Scientific Reports"},{"issue":"1","key":"8880_CR36","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3390\/antiox11010122","volume":"11","author":"G Roch","year":"2022","unstructured":"Roch, G., Batall\u00e9, G., Bai, X., Pouso-V\u00e1zquez, E., Rodr\u00edguez, L., & Pol, O. (2022). The beneficial effects of heme oxygenase 1 and hydrogen sulfide activation in the management of neuropathic pain, Anxiety- and Depressive-like effects of paclitaxel in mice. Antioxidants (Basel, Switzerland), 11(1), 122. https:\/\/doi.org\/10.3390\/antiox11010122","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"17","key":"8880_CR37","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1089\/ars.2020.8217","volume":"34","author":"P Rose","year":"2021","unstructured":"Rose, P., Moore, P. K., Whiteman, M., Kirk, C., & Zhu, Y. Z. (2021). Diet and hydrogen sulfide production in mammals. Antioxidants and Redox Signaling, 34(17), 1378\u20131393. https:\/\/doi.org\/10.1089\/ars.2020.8217","journal-title":"Antioxidants and Redox Signaling"},{"key":"8880_CR38","doi-asserted-by":"publisher","first-page":"1873962","DOI":"10.1155\/2018\/1873962","volume":"2018","author":"U Shefa","year":"2018","unstructured":"Shefa, U., Kim, M. S., Jeong, N. Y., & Jung, J. (2018). Antioxidant and cell-signaling functions of hydrogen sulfide in the central nervous system. Oxidative Medicine and Cellular Longevity, 2018, 1873962. https:\/\/doi.org\/10.1155\/2018\/1873962","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"4","key":"8880_CR39","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1093\/jb\/mvr018","volume":"149","author":"K Tanizawa","year":"2011","unstructured":"Tanizawa, K. (2011). Production of H2S by 3-mercaptopyruvate sulphurtransferase. Journal of Biochemistry, 149(4), 357\u2013359. https:\/\/doi.org\/10.1093\/jb\/mvr018","journal-title":"Journal of Biochemistry"},{"issue":"4","key":"8880_CR40","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1111\/bph.14641","volume":"177","author":"JL Wallace","year":"2020","unstructured":"Wallace, J. L., Nagy, P., Feener, T. D., Allain, T., Ditr\u00f3i, T., Vaughan, D. J., Muscara, M. N., de Nucci, G., & Buret, A. G. (2020). A proof-of-concept, phase 2 clinical trial of the gastrointestinal safety of a hydrogen sulfide-releasing anti-inflammatory drug. British Journal of Pharmacology, 177(4), 769\u2013777. https:\/\/doi.org\/10.1111\/bph.14641","journal-title":"British Journal of Pharmacology"},{"key":"8880_CR41","doi-asserted-by":"publisher","first-page":"119551","DOI":"10.1016\/j.lfs.2021.119551","volume":"278","author":"Y Wang","year":"2021","unstructured":"Wang, Y., Wang, S., Xin, Y., Zhang, J., Wang, S., Yang, Z., & Liu, C. (2021). Hydrogen sulfide alleviates the anxiety-like and depressive-like behaviors of type 1 diabetic mice via inhibiting inflammation and ferroptosis. Life Sciences, 278, 119551. https:\/\/doi.org\/10.1016\/j.lfs.2021.119551","journal-title":"Life Sciences"},{"key":"8880_CR42","doi-asserted-by":"publisher","first-page":"765664","DOI":"10.3389\/fpsyt.2021.765664","volume":"12","author":"YJ Yang","year":"2021","unstructured":"Yang, Y. J., Chen, C. N., Zhan, J. Q., Liu, Q. S., Liu, Y., Jiang, S. Z., & Wei, B. (2021). Decreased plasma hydrogen sulfide level is associated with the severity of depression in patients with depressive disorder. Frontiers in Psychiatry, 12, 765664. https:\/\/doi.org\/10.3389\/fpsyt.2021.765664","journal-title":"Frontiers in Psychiatry"},{"key":"8880_CR43","doi-asserted-by":"publisher","first-page":"113562","DOI":"10.1016\/j.bbr.2021.113562","volume":"417","author":"SQ Yang","year":"2022","unstructured":"Yang, S. Q., Tang, Y. Y., Zeng, D., Tian, Q., Wei, H. J., Wang, C. Y., Zhang, P., Chen, Y. J., Zou, W., & Tang, X. Q. (2022). Sodium hydrosulfide reverses \u03b22-microglobulin-induced depressive-like behaviors of male Sprague-Dawley rats: Involving improvement of synaptic plasticity and enhancement of Warburg effect in hippocampus. Behavioural Brain Research, 417, 113562. https:\/\/doi.org\/10.1016\/j.bbr.2021.113562","journal-title":"Behavioural Brain Research"},{"issue":"1","key":"8880_CR44","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1002\/med.21433","volume":"38","author":"Y Zheng","year":"2018","unstructured":"Zheng, Y., Yu, B., De La Cruz, L. K., Roy Choudhury, M., Anifowose, A., & Wang, B. (2018). Toward hydrogen sulfide based therapeutics: Critical drug delivery and developability issues. Medicinal Research Reviews, 38(1), 57\u2013100. https:\/\/doi.org\/10.1002\/med.21433","journal-title":"Medicinal Research Reviews"}],"container-title":["NeuroMolecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-025-08880-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12017-025-08880-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-025-08880-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T14:41:28Z","timestamp":1767192088000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12017-025-08880-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,8]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["8880"],"URL":"https:\/\/doi.org\/10.1007\/s12017-025-08880-y","relation":{},"ISSN":["1559-1174"],"issn-type":[{"value":"1559-1174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,8]]},"assertion":[{"value":"1 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"58"}}