{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:36:43Z","timestamp":1780497403493,"version":"3.54.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuromol Med"],"DOI":"10.1007\/s12017-025-08897-3","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T04:14:25Z","timestamp":1763612065000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Longikaurin A - Mediated Regulation of ROS\/JNK Signaling Counteracts Epithelial-Mesenchymal Transition in Glioblastoma"],"prefix":"10.1007","volume":"27","author":[{"given":"Hua","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangming","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"8897_CR1","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s10911-007-9044-6","volume":"12","author":"G Agiostratidou","year":"2007","unstructured":"Agiostratidou, G., et al. (2007). Differential cadherin expression: Potential markers for epithelial to mesenchymal transformation during tumor progression. Journal of Mammary Gland Biology and Neoplasia, 12, 127\u2013133.","journal-title":"Journal of Mammary Gland Biology and Neoplasia"},{"key":"8897_CR2","doi-asserted-by":"publisher","first-page":"110909","DOI":"10.1016\/j.biopha.2020.110909","volume":"133","author":"G Babaei","year":"2021","unstructured":"Babaei, G., et al. (2021). EMT, cancer stem cells and autophagy; the three main axes of metastasis. Biomedicine & Pharmacotherapy, 133, 110909.","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"8897_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120791","volume":"306","author":"LP Chan","year":"2022","unstructured":"Chan, L. P., et al. (2022). Growth regulated oncogene-\u03b1 contribute to EMT\/MMPs pathway by binding its receptors in head and neck squamous cell carcinoma. Life Sciences, 306, Article 120791.","journal-title":"Life Sciences"},{"key":"8897_CR4","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.toxlet.2017.08.005","volume":"280","author":"Y Che","year":"2017","unstructured":"Che, Y., et al. (2017). The therapeutic effects of Longikaurin A, a natural ent-kauranoid, in esophageal squamous cell carcinoma depend on ROS accumulation and JNK\/p38 MAPK activation. Toxicology Letters, 280, 106\u2013115.","journal-title":"Toxicology Letters"},{"key":"8897_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.766581","volume":"13","author":"X Chen","year":"2022","unstructured":"Chen, X., et al. (2022). Isodon rubescens (Hemls.) Hara.: A comprehensive review on traditional uses, phytochemistry, and pharmacological activities. Frontiers in Pharmacology, 13, Article 766581.","journal-title":"Frontiers in Pharmacology"},{"key":"8897_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2015.00769","volume":"6","author":"SK Jalmi","year":"2015","unstructured":"Jalmi, S. K., et al. (2015). ROS mediated MAPK signaling in abiotic and biotic stress- Striking similarities and differences. Frontiers in Plant Science, 6, Article 769.","journal-title":"Frontiers in Plant Science"},{"issue":"9","key":"8897_CR7","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.1111\/cas.70126","volume":"116","author":"S Kanayama","year":"2025","unstructured":"Kanayama, S., et al. (2025). Epithelial-mesenchymal transition and genetically driven early tumor seedings in extraneural metastasis of glioblastoma. Cancer Science, 116(9), 2607\u20132612.","journal-title":"Cancer Science"},{"key":"8897_CR8","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s13046-016-0359-2","volume":"35","author":"S Kaufhold","year":"2016","unstructured":"Kaufhold, S., et al. (2016). Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication. Journal of Experimental & Clinical Cancer Research : Cr, 35, 84.","journal-title":"Journal of Experimental & Clinical Cancer Research : Cr"},{"issue":"1","key":"8897_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-023-11796-0","volume":"24","author":"L Li","year":"2024","unstructured":"Li, L., et al. (2024). EMP3 as a prognostic biomarker correlates with EMT in GBM. BMC Cancer, 24(1), Article 89.","journal-title":"BMC Cancer"},{"key":"8897_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.66","volume":"5","author":"YJ Liao","year":"2014","unstructured":"Liao, Y. J. (2014). Longikaurin a, a natural ent-kaurane, induces G2\/M phase arrest via downregulation of Skp2 and apoptosis induction through ROS\/JNK\/c-Jun pathway in hepatocellular carcinoma cells. Cell Death and Disease, 5(3), e1137.","journal-title":"Cell Death and Disease"},{"key":"8897_CR11","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.cell.2008.03.027","volume":"133","author":"SA Mani","year":"2008","unstructured":"Mani, S. A., et al. (2008). The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell, 133, 704\u2013715.","journal-title":"Cell"},{"issue":"12 Suppl 2","key":"8897_CR12","doi-asserted-by":"publisher","first-page":"iv1","DOI":"10.1093\/neuonc\/noad149","volume":"25","author":"QT Ostrom","year":"2023","unstructured":"Ostrom, Q. T., et al. (2023). CBTRUS statistical report: Primary brain and other central nervous system tumors diagnosed in the united States in 2016\u20132020. Neuro Oncol, 25(12 Suppl 2), iv1\u2013iv99.","journal-title":"Neuro Oncol"},{"key":"8897_CR13","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/s41586-018-0040-3","volume":"556","author":"I Pastushenko","year":"2018","unstructured":"Pastushenko, I., et al. (2018). Identification of the tumour transition states occurring during EMT. Nature, 556, 463\u2013468.","journal-title":"Nature"},{"key":"8897_CR14","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1001\/jama.2023.0023","volume":"329","author":"LR Schaff","year":"2023","unstructured":"Schaff, L. R., et al. (2023). Glioblastoma and other primary brain malignancies in adults: A review. Journal of the American Medical Association, 329, 574\u2013587.","journal-title":"Journal of the American Medical Association"},{"key":"8897_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156060","volume":"135","author":"A \u015eengelen","year":"2024","unstructured":"\u015eengelen, A. (2024). Rosmarinic acid attenuates glioblastoma cells and spheroids\u2019 growth and EMT\/stem-like state by PTEN\/PI3K\/AKT downregulation and ERK-induced apoptosis. Phytomedicine, 135, Article 156060.","journal-title":"Phytomedicine"},{"key":"8897_CR16","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1097\/WNR.0000000000000320","volume":"26","author":"L Shi","year":"2015","unstructured":"Shi, L., et al. (2015). Curcumin induces glioma stem-like cell formation. Neuroreport, 26, 167\u2013172.","journal-title":"Neuroreport"},{"issue":"24","key":"8897_CR17","doi-asserted-by":"publisher","first-page":"15183","DOI":"10.18632\/aging.205340","volume":"15","author":"L Shi","year":"2023","unstructured":"Shi, L., et al. (2023). Inhibition of TGF-\u03b21-induced epithelial-mesenchymal transition in gliomas by. Aging (Albany NY), 15(24), 15183\u201315195.","journal-title":"Aging (Albany NY)"},{"issue":"728","key":"8897_CR18","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adg3840","volume":"16","author":"JJF Sleeboom","year":"2024","unstructured":"Sleeboom, J. J. F., et al. (2024). The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets. Science Translational Medicine, 16(728), Article eadg3840.","journal-title":"Science Translational Medicine"},{"key":"8897_CR19","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.2147\/OTT.S236111","volume":"13","author":"L Song","year":"2020","unstructured":"Song, L., et al. (2020). EFEMP2 suppresses the invasion of lung cancer cells by inhibiting Epithelial-Mesenchymal transition (EMT) and Down-Regulating MMPs. Onco Targets Ther, 13, 1375\u20131396.","journal-title":"Onco Targets Ther"},{"key":"8897_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2025.156111","volume":"272","author":"Y Tian","year":"2025","unstructured":"Tian, Y., et al. (2025). Molecular drivers of epithelial-mesenchymal transition (EMT) in glioblastoma and impact on therapy resistance. Pathology, Research and Practice, 272, Article 156111.","journal-title":"Pathology, Research and Practice"},{"issue":"8","key":"8897_CR21","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/nrc2694","volume":"9","author":"EF Wagner","year":"2009","unstructured":"Wagner, E. F., et al. (2009). Signal integration by JNK and p38 MAPK pathways in cancer development. Nature Reviews Cancer, 9(8), 537\u2013549.","journal-title":"Nature Reviews Cancer"},{"key":"8897_CR22","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1142\/S0192415X20500354","volume":"48","author":"J Wang","year":"2020","unstructured":"Wang, J., et al. (2020). Cinobufacini inhibits colon cancer invasion and metastasis via suppressing Wnt\/\u03b2-catenin signaling pathway and EMT. American Journal of Chinese Medicine, 48, 703\u2013718.","journal-title":"American Journal of Chinese Medicine"},{"issue":"1","key":"8897_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-92317-w","volume":"15","author":"R Wei","year":"2025","unstructured":"Wei, R., et al. (2025). ATXN3 deubiquitinates ZEB1 and facilitates epithelial-mesenchymal transition in glioblastoma. Scientific Reports, 15(1), Article 7868.","journal-title":"Scientific Reports"},{"issue":"1","key":"8897_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2025.101711","volume":"3","author":"P Xia","year":"2025","unstructured":"Xia, P. (2025). The significance of epithelial-mesenchymal transition (EMT) in the initiation, plasticity, and treatment of glioblastoma. Genes and Diseases, 3(1), Article 101711.","journal-title":"Genes and Diseases"},{"key":"8897_CR25","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.3892\/ol.2017.5625","volume":"13","author":"Y Yuan","year":"2017","unstructured":"Yuan, Y., et al. (2017). Longikaurin a, a natural ent-kaurane, suppresses stemness in nasopharyngeal carcinoma cells. Oncology Letters, 13, 1672\u20131680.","journal-title":"Oncology Letters"},{"issue":"3","key":"8897_CR26","first-page":"611","volume":"20","author":"S Zhao","year":"2012","unstructured":"Zhao, S., et al. (2012). Longikaurin A induces apoptosis of multiple myeloma H929 cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 20(3), 611\u2013615.","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"}],"container-title":["NeuroMolecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-025-08897-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12017-025-08897-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-025-08897-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T14:41:34Z","timestamp":1767192094000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12017-025-08897-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,20]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["8897"],"URL":"https:\/\/doi.org\/10.1007\/s12017-025-08897-3","relation":{},"ISSN":["1559-1174"],"issn-type":[{"value":"1559-1174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,20]]},"assertion":[{"value":"30 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"During the preparation of this work the authors used Chatgpt in order to proceed language modification. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration of generative ai and ai-assisted technologies in the writing process"}}],"article-number":"74"}}