{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T18:18:43Z","timestamp":1788027523338,"version":"build-2784847793"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["ORF-2026-748"],"award-info":[{"award-number":["ORF-2026-748"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuromol Med"],"DOI":"10.1007\/s12017-026-08947-4","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T16:35:57Z","timestamp":1788021357000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["AMBMP Hydrochloride Reverses STZ-Induced Alzheimer-Type Dementia Associated with Wnt\/\u03b2-catenin\/TLR4 Signaling"],"prefix":"10.1007","volume":"28","author":[{"given":"Palak","family":"Kalra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Chaturvedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarjot Kaur","family":"Grewal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heena","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varinder","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thakur Gurjeet","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanveer","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheikh F.","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabry M.","family":"Attia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"issue":"12","key":"8947_CR1","doi-asserted-by":"publisher","first-page":"902","DOI":"10.3390\/brainsci10120902","volume":"10","author":"ND Aghaizu","year":"2020","unstructured":"Aghaizu, N. D., Jin, H., & Whiting, P. J. (2020). Dysregulated Wnt signalling in the Alzheimer\u2019s brain. Brain Sciences, 10(12), 902.","journal-title":"Brain Sciences"},{"key":"8947_CR2","doi-asserted-by":"crossref","unstructured":"Anand, A. A., Khan, M., V, M. and, & Kar, D. (2023). The molecular basis of Wnt\/\u03b2-catenin signaling pathways in neurodegenerative diseases. International Journal of Cell Biology, 2023(1), p.9296092.","DOI":"10.1155\/2023\/9296092"},{"issue":"7","key":"8947_CR3","doi-asserted-by":"publisher","first-page":"5629","DOI":"10.1007\/s11033-021-06512-9","volume":"48","author":"T Athar","year":"2021","unstructured":"Athar, T., Balushi, A., K. and, & Khan, S. A. (2021). Recent advances on drug development and emerging therapeutic agents for Alzheimer\u2019s disease. Molecular biology reports, 48(7), 5629\u20135645.","journal-title":"Molecular biology reports"},{"issue":"1","key":"8947_CR4","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3390\/brainsci13010145","volume":"13","author":"K Barber","year":"2023","unstructured":"Barber, K., Mendonca, P., & Soliman, K. F. (2023). The neuroprotective effects and therapeutic potential of the chalcone cardamonin for Alzheimer\u2019s disease. Brain Sciences, 13(1), 145.","journal-title":"Brain Sciences"},{"issue":"2","key":"8947_CR5","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/0003-2697(72)90335-1","volume":"46","author":"AF Boyne","year":"1972","unstructured":"Boyne, A. F., & Ellman, G. L. (1972). A methodology for analysis of tissue sulfhydryl components. Analytical biochemistry, 46(2), 639\u2013653.","journal-title":"Analytical biochemistry"},{"issue":"6","key":"8947_CR6","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.3390\/molecules27061816","volume":"27","author":"ZR Chen","year":"2022","unstructured":"Chen, Z. R., Huang, J. B., Yang, S. L., & Hong, F. F. (2022). Role of cholinergic signaling in Alzheimer\u2019s disease. Molecules, 27(6), 1816.","journal-title":"Molecules"},{"issue":"1","key":"8947_CR7","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/jnc.14608","volume":"149","author":"P Cisternas","year":"2019","unstructured":"Cisternas, P., Zolezzi, J. M., Martinez, M., Torres, V. I., Wong, G. W., & Inestrosa, N. C. (2019). Wnt-induced activation of glucose metabolism mediates the in vivo neuroprotective roles of Wnt signaling in Alzheimer disease. Journal of neurochemistry, 149(1), 54\u201372.","journal-title":"Journal of neurochemistry"},{"issue":"2","key":"8947_CR8","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.arr.2011.01.001","volume":"10","author":"SC Correia","year":"2011","unstructured":"Correia, S. C., Santos, R. X., Perry, G., Zhu, X., Moreira, P. I., & Smith, M. A. (2011). Insulin-resistant brain state: the culprit in sporadic Alzheimer\u2019s disease? Ageing research reviews, 10(2), 264\u2013273.","journal-title":"Ageing research reviews"},{"issue":"2","key":"8947_CR9","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"GL Ellman","year":"1961","unstructured":"Ellman, G. L., Courtney, K. D., AndresJr, V., & Featherstone, R. M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical pharmacology, 7(2), 88\u201395.","journal-title":"Biochemical pharmacology"},{"key":"8947_CR10","doi-asserted-by":"publisher","first-page":"309","DOI":"10.3389\/fncel.2019.00309","volume":"13","author":"C Fabiani","year":"2019","unstructured":"Fabiani, C., & Antollini, S. S. (2019). Alzheimer\u2019s disease as a membrane disorder: spatial cross-talk among beta-amyloid peptides, nicotinic acetylcholine receptors and lipid rafts. Frontiers in cellular neuroscience, 13, 309.","journal-title":"Frontiers in cellular neuroscience"},{"issue":"5","key":"8947_CR11","doi-asserted-by":"publisher","first-page":"e0322708","DOI":"10.1371\/journal.pone.0322708","volume":"20","author":"L Gao","year":"2025","unstructured":"Gao, L., Hu, S., Lv, Y., Zheng, G., & Lin, Z. (2025). Overexpression of LINC00672 promotes autophagy in Alzheimer\u2019s disease by upregulating GPNMB. PLoS One, 20(5), e0322708.","journal-title":"PLoS One"},{"key":"8947_CR12","doi-asserted-by":"crossref","unstructured":"Gautam, P., Singh, V., Kanwar, N., Shri, R., Singh, T., Singh, M., Singh, T. G., Grewal, A. K., Kumar, A., Singh, R., & Ahmad, S. F. (2025 Aug). Hesperidin mitigates lead-induced neurotoxicity via TFEB-dependent restoration of mitochondrial function, oxidative balance, and neuroinflammation in rats. Neurotoxicology, 30, 103310.","DOI":"10.1016\/j.neuro.2025.103310"},{"issue":"s1","key":"8947_CR13","doi-asserted-by":"publisher","first-page":"S107","DOI":"10.3233\/JAD-179921","volume":"64","author":"CX Gong","year":"2018","unstructured":"Gong, C. X., Liu, F., & Iqbal, K. (2018). Multifactorial hypothesis and multi-targets for Alzheimer\u2019s disease. Journal of Alzheimer\u2019s Disease, 64(s1), S107\u2013S117.","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"3","key":"8947_CR14","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1007\/s12035-015-9132-3","volume":"53","author":"P Grieb","year":"2016","unstructured":"Grieb, P. (2016). Intracerebroventricular streptozotocin injections as a model of Alzheimer\u2019s disease: in search of a relevant mechanism. Molecular neurobiology, 53(3), 1741\u20131752.","journal-title":"Molecular neurobiology"},{"issue":"21","key":"8947_CR15","first-page":"2003","volume":"8","author":"C Guo","year":"2013","unstructured":"Guo, C., Sun, L., Chen, X., & Zhang, D. (2013). Oxidative stress, mitochondrial damage and neurodegenerative diseases. Neural regeneration research, 8(21), 2003\u20132014.","journal-title":"Neural regeneration research"},{"issue":"1","key":"8947_CR16","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13024-020-00391-7","volume":"15","author":"T Guo","year":"2020","unstructured":"Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020). Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer\u2019s disease. Molecular neurodegeneration, 15(1), 40.","journal-title":"Molecular neurodegeneration"},{"issue":"s1","key":"8947_CR17","doi-asserted-by":"publisher","first-page":"S51","DOI":"10.3233\/JAD-201059","volume":"82","author":"L Guzman-Martinez","year":"2021","unstructured":"Guzman-Martinez, L., Calf\u00edo, C., Farias, G. A., Vilches, C., Prieto, R., & Maccioni, R. B. (2021). New frontiers in the prevention, diagnosis, and treatment of Alzheimer\u2019s disease. Journal of Alzheimer\u2019s Disease, 82(s1), S51\u2013S63.","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"4","key":"8947_CR19","doi-asserted-by":"publisher","first-page":"249","DOI":"10.2174\/1567205043332063","volume":"1","author":"NC Inestrosa","year":"2004","unstructured":"Inestrosa, N. C., Urra, S., & Colombres, M. (2004). Acetylcholinesterase (AChE)-amyloid-\u03b2-peptide complexes in Alzheimer\u2019s disease. The Wnt signaling pathway. Current Alzheimer Research, 1(4), 249\u2013254.","journal-title":"Current Alzheimer Research"},{"issue":"4","key":"8947_CR18","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1007\/s11481-012-9417-5","volume":"7","author":"NC Inestrosa","year":"2012","unstructured":"Inestrosa, N. C., Montecinos-Oliva, C., & Fuenzalida, M. (2012). Wnt signaling: role in Alzheimer disease and schizophrenia. Journal of Neuroimmune Pharmacology, 7(4), 788\u2013807.","journal-title":"Journal of Neuroimmune Pharmacology"},{"issue":"1","key":"8947_CR20","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s13041-019-0525-5","volume":"12","author":"L Jia","year":"2019","unstructured":"Jia, L., Pi\u00f1a-Crespo, J., & Li, Y. (2019). Restoring Wnt\/\u03b2-catenin signaling is a promising therapeutic strategy for Alzheimer\u2019s disease. Molecular brain, 12(1), 104.","journal-title":"Molecular brain"},{"key":"8947_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2016.07.005","volume":"147","author":"T Jiang","year":"2016","unstructured":"Jiang, T., Sun, Q., & Chen, S. (2016). Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson\u2019s disease and Alzheimer\u2019s disease. Progress in neurobiology, 147, 1\u201319.","journal-title":"Progress in neurobiology"},{"issue":"7","key":"8947_CR22","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.4103\/1673-5374.160076","volume":"10","author":"PK Kamat","year":"2015","unstructured":"Kamat, P. K. (2015). Streptozotocin induced Alzheimer\u2019s disease like changes and the underlying neural degeneration and regeneration mechanism. Neural regeneration research, 10(7), 1050\u20131052.","journal-title":"Neural regeneration research"},{"issue":"1","key":"8947_CR23","doi-asserted-by":"publisher","first-page":"985085","DOI":"10.4061\/2011\/985085","volume":"2011","author":"K Kanninen","year":"2011","unstructured":"Kanninen, K., White, A. R., Koistinaho, J., & Malm, T. (2011). Targeting Glycogen Synthase Kinase-3\u03b2 for Therapeutic Benefit against Oxidative Stress in Alzheimer\u2032 s Disease: Involvement of the Nrf2\u2010ARE Pathway. International Journal of Alzheimer\u2019s Disease, 2011(1), 985085.","journal-title":"International Journal of Alzheimer\u2019s Disease"},{"issue":"1","key":"8947_CR25","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/s10571-024-01521-1","volume":"45","author":"D Kaur","year":"2024","unstructured":"Kaur, D., Grewal, A. K., Fouad, D., Kumar, A., Singh, V., Alexiou, A., Papadakis, M., Batiha, G. E., Welson, N. N., & Singh, T. G. (2024). Exploring the neuroprotective effects of rufinamide in a streptozotocin-induced dementia model. Cellular and Molecular Neurobiology, 45(1), 4.","journal-title":"Cellular and Molecular Neurobiology"},{"issue":"1","key":"8947_CR24","doi-asserted-by":"publisher","first-page":"28963","DOI":"10.1038\/s41598-025-13920-5","volume":"15","author":"D Kaur","year":"2025","unstructured":"Kaur, D., Grewal, A. K., Almasoudi, S. H., Almehmadi, A. H., Alsfouk, B. A., Kumar, A., Singh, V., Alexiou, A., Papadakis, M., Welson, N. N., & Singh, T. G. (2025). Neuroprotective effect of Tozasertib in Streptozotocin-induced alzheimer\u2019s mice model. Scientific Reports, 15(1), 28963.","journal-title":"Scientific Reports"},{"issue":"19","key":"8947_CR26","doi-asserted-by":"publisher","first-page":"10637","DOI":"10.3390\/ijms221910637","volume":"22","author":"J Kim","year":"2021","unstructured":"Kim, J., Lee, H. J., Park, S. K., Park, J. H., Jeong, H. R., Lee, S., Lee, H., Seol, E., & Hoe, H. S. (2021). Donepezil regulates LPS and A\u03b2-stimulated neuroinflammation through MAPK\/NLRP3 inflammasome\/STAT3 signaling. International journal of molecular sciences, 22(19), 10637.","journal-title":"International journal of molecular sciences"},{"issue":"2 and 3","key":"8947_CR27","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/FBP.0000000000000294","volume":"28","author":"A Kumar","year":"2017","unstructured":"Kumar, A., & Singh, N. (2017a). Pharmacological activation of protein kinase A improves memory loss and neuropathological changes in a mouse model of dementia of Alzheimer\u2019s type. Behavioural pharmacology, 28(2 and 3), 187\u2013198.","journal-title":"Behavioural pharmacology"},{"key":"8947_CR28","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.biopha.2017.01.059","volume":"88","author":"A Kumar","year":"2017","unstructured":"Kumar, A., & Singh, N. (2017b). Inhibitor of Phosphodiestearse-4 improves memory deficits, oxidative stress, neuroinflammation and neuropathological alterations in mouse models of dementia of Alzheimer\u2019s Type. Biomedicine & pharmacotherapy, 88, 698\u2013707.","journal-title":"Biomedicine & pharmacotherapy"},{"issue":"1","key":"8947_CR29","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/s41420-023-01618-4","volume":"9","author":"X Lin","year":"2023","unstructured":"Lin, X., Wang, P., Wang, W., Zhou, H., Zhu, S., Feng, S., Chen, Y., Zhou, H., Wang, Q., Xin, H., & Shao, X. (2023). Suppressed Akt\/GSK-3\u03b2\/\u03b2-catenin signaling contributes to excessive adipogenesis of fibro-adipogenic progenitors after rotator cuff tears. Cell death discovery, 9(1), 312.","journal-title":"Cell death discovery"},{"key":"8947_CR30","doi-asserted-by":"crossref","unstructured":"Liu, J., Campagna, J., John, V., Damoiseaux, R., Mokhonova, E., Becerra, D., Meng, H., McNally, E. M., Pyle, A. D., Kramerova, I., & Spencer, M. J. (2020). A small-molecule approach to restore a slow-oxidative phenotype and defective CaMKII\u03b2 signaling in limb girdle muscular dystrophy. Cell Reports Medicine, 1(7).","DOI":"10.1016\/j.xcrm.2020.100122"},{"issue":"6","key":"8947_CR31","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1016\/j.ejmech.2011.03.058","volume":"46","author":"W Luo","year":"2011","unstructured":"Luo, W., Li, Y. P., He, Y., Huang, S. L., Li, D., Gu, L. Q., & Huang, Z. S. (2011). Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents. European journal of medicinal chemistry, 46(6), 2609\u20132616.","journal-title":"European journal of medicinal chemistry"},{"issue":"5","key":"8947_CR32","doi-asserted-by":"publisher","first-page":"706","DOI":"10.2174\/1567202617666201214112016","volume":"17","author":"V Mehta","year":"2020","unstructured":"Mehta, V., Kumar, A., Jaggi, A. S., & Singh, N. (2020). Restoration of the attenuated neuroprotective effect of ischemic postconditioning in diabetic mice by SGLT inhibitor phlorizin. Current neurovascular research, 17(5), 706\u2013718.","journal-title":"Current neurovascular research"},{"issue":"19","key":"8947_CR33","doi-asserted-by":"publisher","first-page":"3449","DOI":"10.1021\/acschemneuro.4c00167","volume":"15","author":"SK Mishra","year":"2024","unstructured":"Mishra, S. K., & Mishra, V. (2024). Saroglitazar enhances memory functions and adult neurogenesis via up-regulation of Wnt\/\u03b2 catenin signaling in the rat model of dementia. ACS Chemical Neuroscience, 15(19), 3449\u20133458.","journal-title":"ACS Chemical Neuroscience"},{"issue":"9","key":"8947_CR34","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.metabol.2014.06.002","volume":"63","author":"ML Moon","year":"2014","unstructured":"Moon, M. L., Joesting, J. J., Lawson, M. A., Chiu, G. S., Blevins, N. A., Kwakwa, K. A., & Freund, G. G. (2014). The saturated fatty acid, palmitic acid, induces anxiety-like behavior in mice. Metabolism, 63(9), 1131\u20131140.","journal-title":"Metabolism"},{"issue":"20","key":"8947_CR35","doi-asserted-by":"publisher","first-page":"e3397","DOI":"10.21769\/BioProtoc.3397","volume":"9","author":"D Moreira-Silva","year":"2019","unstructured":"Moreira-Silva, D., Vizin, R. C., Martins, T. M., Ferreira, T. L., Almeida, M. C., & Carrettiero, D. C. (2019). Intracerebral injection of streptozotocin to model Alzheimer disease in rats. Bio-protocol, 9(20), e3397\u2013e3397.","journal-title":"Bio-protocol"},{"issue":"1","key":"8947_CR36","first-page":"43","volume":"15","author":"M Nasb","year":"2024","unstructured":"Nasb, M., Tao, W., & Chen, N. (2024). Alzheimer\u2019s disease puzzle: delving into pathogenesis hypotheses. Aging and disease, 15(1), 43.","journal-title":"Aging and disease"},{"key":"8947_CR37","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa, H., Ohesli, N., & Yagi, K. (1979). Assay of lipid peroxidation in animal tissue by TBARS. Analytical Biochemistry, 95, 351\u2013358.","journal-title":"Analytical Biochemistry"},{"issue":"6","key":"8947_CR38","doi-asserted-by":"publisher","first-page":"618","DOI":"10.2174\/15672050113109990132","volume":"10","author":"M Oz","year":"2013","unstructured":"Oz, M., Lorke, E., Yang, D. S., K.H. and, & Petroianu, G. (2013). On the interaction of \u03b2-amyloid peptides and \u03b17-nicotinic acetylcholine receptors in Alzheimer\u2019s disease. Current Alzheimer Research, 10(6), 618\u2013630.","journal-title":"Current Alzheimer Research"},{"key":"8947_CR39","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3389\/fncel.2019.00227","volume":"13","author":"E Palomer","year":"2019","unstructured":"Palomer, E., Buechler, J., & Salinas, P. C. (2019). Wnt signaling deregulation in the aging and Alzheimer\u2019s brain. Frontiers in cellular neuroscience, 13, 227.","journal-title":"Frontiers in cellular neuroscience"},{"key":"8947_CR40","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3389\/fncel.2020.00235","volume":"14","author":"J Park","year":"2020","unstructured":"Park, J., Won, J., Seo, J., Yeo, H. G., Kim, K., Kim, Y. G., Jeon, C. Y., Kam, M. K., Kim, Y. H., Huh, J. W., & Lee, S. R. (2020). Streptozotocin induces Alzheimer\u2019s disease-like pathology in hippocampal neuronal cells via CDK5\/Drp1-mediated mitochondrial fragmentation. Frontiers in cellular neuroscience, 14, 235.","journal-title":"Frontiers in cellular neuroscience"},{"issue":"1","key":"8947_CR41","doi-asserted-by":"publisher","first-page":"15642","DOI":"10.1038\/s41598-024-66256-x","volume":"14","author":"J Park","year":"2024","unstructured":"Park, J., Won, J., Yang, E., Seo, J., Cho, J., Seong, J. B., Yeo, H. G., Kim, K., Kim, Y. G., Kim, M., & Jeon, C. Y. (2024). Peroxiredoxin 1 inhibits streptozotocin-induced Alzheimer\u2019s disease-like pathology in hippocampal neuronal cells via the blocking of Ca2+\/Calpain\/Cdk5-mediated mitochondrial fragmentation. Scientific Reports, 14(1), 15642.","journal-title":"Scientific Reports"},{"issue":"1","key":"8947_CR42","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/s41380-019-0468-3","volume":"25","author":"J Penney","year":"2020","unstructured":"Penney, J., Ralvenius, W. T., & Tsai, L. H. (2020). Modeling Alzheimer\u2019s disease with iPSC-derived brain cells. Molecular psychiatry, 25(1), 148\u2013167.","journal-title":"Molecular psychiatry"},{"key":"8947_CR43","doi-asserted-by":"publisher","first-page":"633495","DOI":"10.3389\/fnagi.2021.633495","volume":"13","author":"CC Qi","year":"2021","unstructured":"Qi, C. C., Chen, X. X., Gao, X. R., Xu, J. X., Liu, S., & Ge, J. F. (2021). Impaired learning and memory ability induced by a bilaterally hippocampal injection of streptozotocin in mice: involved with the adaptive changes of synaptic plasticity. Frontiers in aging neuroscience, 13, 633495.","journal-title":"Frontiers in aging neuroscience"},{"key":"8947_CR44","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.arr.2017.02.004","volume":"36","author":"M Rahimifard","year":"2017","unstructured":"Rahimifard, M., Maqbool, F., Moeini-Nodeh, S., Niaz, K., Abdollahi, M., Braidy, N., Nabavi, S. M., & Nabavi, S. F. (2017). Targeting the TLR4 signaling pathway by polyphenols: a novel therapeutic strategy for neuroinflammation. Ageing research reviews, 36, 11\u201319.","journal-title":"Ageing research reviews"},{"issue":"6","key":"8947_CR45","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1515\/jbcpp-2020-0330","volume":"32","author":"R Rani","year":"2021","unstructured":"Rani, R., Kumar, A., Jaggi, A. S., & Singh, N. (2021). Pharmacological investigations on efficacy of Phlorizin a sodium-glucose co-transporter (SGLT) inhibitor in mouse model of intracerebroventricular streptozotocin induced dementia of AD type. Journal of Basic and Clinical Physiology and Pharmacology, 32(6), 1057\u20131064.","journal-title":"Journal of Basic and Clinical Physiology and Pharmacology"},{"key":"8947_CR46","doi-asserted-by":"publisher","first-page":"148175","DOI":"10.1016\/j.brainres.2022.148175","volume":"1799","author":"SS Silva","year":"2023","unstructured":"Silva, S. S., Tureck, L. V., Souza, L. C., Mello-Hortega, J. V., Piumbini, A. L., Teixeira, M. D., Furtado-Alle, L., Vital, M. A., & Souza, R. L. (2023). Animal model of Alzheimer\u2019s disease induced by streptozotocin: New insights about cholinergic pathway. Brain research, 1799, 148175.","journal-title":"Brain research"},{"key":"8947_CR47","unstructured":"Song, J., Zhu, X. M., & Wei, Q. Y. (2020). MSCs reduce airway remodeling in the lungs of asthmatic rats through the Wnt\/\u03b2-catenin signaling pathway. European Review for Medical & Pharmacological Sciences, 24(21)."},{"issue":"5","key":"8947_CR48","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1007\/s11011-023-01199-2","volume":"38","author":"P Sood","year":"2023","unstructured":"Sood, P., Singh, V., & Shri, R. (2023). Morus alba fruit diet ameliorates cognitive deficit in mouse model of streptozotocin-induced memory impairment. Metabolic Brain Disease, 38(5), 1657\u20131669.","journal-title":"Metabolic Brain Disease"},{"issue":"1","key":"8947_CR49","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s11064-023-04009-4","volume":"49","author":"P Sood","year":"2024","unstructured":"Sood, P., Singh, V., & Shri, R. (2024). Morus alba fruit extract and its fractions ameliorate streptozotocin induced cognitive deficit in mice via modulating oxidative and cholinergic systems. Neurochemical research, 49(1), 52\u201365.","journal-title":"Neurochemical research"},{"issue":"6","key":"8947_CR50","doi-asserted-by":"publisher","first-page":"e0286086","DOI":"10.1371\/journal.pone.0286086","volume":"18","author":"Y Su","year":"2023","unstructured":"Su, Y., Wang, D., Liu, N., Yang, J., Sun, R., & Zhang, Z. (2023). Clostridium butyricum improves cognitive dysfunction in ICV-STZ-induced Alzheimer\u2019s disease mice via suppressing TLR4 signaling pathway through the gut-brain axis. PLoS One, 18(6), e0286086.","journal-title":"PLoS One"},{"issue":"2","key":"8947_CR52","first-page":"594","volume":"15","author":"N Titisari","year":"2025","unstructured":"Titisari, N., Ahmad, H., Samsulrizal, N., Fauzi, A., & Razak, I. S. A. (2025). The mechanism underlying streptozotocin injection for the development of a nontransgenic Alzheimer\u2019s disease animal model. Open Veterinary Journal, 15(2), 594.","journal-title":"Open Veterinary Journal"},{"issue":"4","key":"8947_CR53","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.3233\/JAD-161088","volume":"57","author":"E T\u00f6nnies","year":"2017","unstructured":"T\u00f6nnies, E., & Trushina, E. (2017). Oxidative stress, synaptic dysfunction, and Alzheimer\u2019s disease. Journal of Alzheimer\u2019s disease, 57(4), 1105\u20131121.","journal-title":"Journal of Alzheimer\u2019s disease"},{"issue":"10","key":"8947_CR54","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1093\/abbs\/gmx073","volume":"49","author":"A Vall\u00e9e","year":"2017","unstructured":"Vall\u00e9e, A., Lecarpentier, Y., Guillevin, R., & Vall\u00e9e, J. N. (2017). Effects of cannabidiol interactions with Wnt\/\u03b2-catenin pathway and PPAR\u03b3 on oxidative stress and neuroinflammation in Alzheimer\u2019s disease. Acta biochimica et biophysica Sinica, 49(10), 853\u2013866.","journal-title":"Acta biochimica et biophysica Sinica"},{"key":"8947_CR55","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.expneurol.2014.11.005","volume":"264","author":"JY Vargas","year":"2015","unstructured":"Vargas, J. Y., Ahumada, J., Arr\u00e1zola, M. S., Fuenzalida, M., & Inestrosa, N. C. (2015). WASP-1, a canonical Wnt signaling potentiator, rescues hippocampal synaptic impairments induced by A\u03b2 oligomers. Experimental neurology, 264, 14\u201325.","journal-title":"Experimental neurology"},{"issue":"1","key":"8947_CR56","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s00011-015-0891-0","volume":"65","author":"H Wang","year":"2016","unstructured":"Wang, H., Graves, M. W., Zhou, H., Gu, Z., Lamont, R. J., & Scott, D. A. (2016). 2-Amino-4-(3, 4-(methylenedioxy) benzylamino)-6-(3-methoxyphenyl) pyrimidine is an anti-inflammatory TLR-2,-4 and-5 response mediator in human monocytes. Inflammation Research, 65(1), 61\u201369.","journal-title":"Inflammation Research"},{"issue":"3","key":"8947_CR57","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1002\/tox.24070","volume":"39","author":"D Wu","year":"2024","unstructured":"Wu, D., Piao, L., & Wang, G. (2024). Tescalcin modulates bone marrow-derived mesenchymal stem cells osteogenic differentiation via the Wnt\/\u03b2\u2010catenin signaling pathway. Environmental Toxicology, 39(3), 1836\u20131846.","journal-title":"Environmental Toxicology"},{"key":"8947_CR58","doi-asserted-by":"publisher","first-page":"724","DOI":"10.3389\/fimmu.2020.00724","volume":"11","author":"J Yang","year":"2020","unstructured":"Yang, J., Wise, L., & Fukuchi, K. I. (2020). TLR4 cross-talk with NLRP3 inflammasome and complement signaling pathways in Alzheimer\u2019s disease. Frontiers in immunology, 11, 724.","journal-title":"Frontiers in immunology"},{"issue":"1","key":"8947_CR59","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s10020-023-00697-4","volume":"29","author":"B Ye","year":"2023","unstructured":"Ye, B., Yuan, Y., Liu, R., Zhou, H., Li, Y., Sheng, Z., Li, T., Zhang, B., Xu, Z., Li, Y., & Liu, Z. (2023). Restoring Wnt signaling in a hormone-simulated postpartum depression model remediated imbalanced neurotransmission and depressive-like behaviors. Molecular Medicine, 29(1), 101.","journal-title":"Molecular Medicine"},{"issue":"5","key":"8947_CR60","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1002\/eji.201343959","volume":"44","author":"CH Yu","year":"2014","unstructured":"Yu, C. H., Nguyen, T. T., Irvine, K. M., Sweet, M. J., Frazer, I. H., & Blumenthal, A. (2014). Recombinant W nt3a and W nt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4. European journal of immunology, 44(5), 1480\u20131490.","journal-title":"European journal of immunology"},{"key":"8947_CR61","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3389\/fimmu.2017.00187","volume":"8","author":"JM Zolezzi","year":"2017","unstructured":"Zolezzi, J. M., & Inestrosa, N. C. (2017). Wnt\/TLR dialog in neuroinflammation, relevance in Alzheimer\u2019s disease. Frontiers in Immunology, 8, 187.","journal-title":"Frontiers in Immunology"}],"container-title":["NeuroMolecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-026-08947-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12017-026-08947-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-026-08947-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T18:02:05Z","timestamp":1788026525000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12017-026-08947-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,29]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8947"],"URL":"https:\/\/doi.org\/10.1007\/s12017-026-08947-4","relation":{},"ISSN":["1559-1174"],"issn-type":[{"value":"1559-1174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,29]]},"assertion":[{"value":"23 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"50"}}