{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T18:46:00Z","timestamp":1791744360449,"version":"4.3.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuromol Med"],"DOI":"10.1007\/s12017-026-08951-8","type":"journal-article","created":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T18:09:45Z","timestamp":1791742185000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sigma-1 Receptor Mitigates Poly-GR-Associated Redox Dysregulation by Restoring NRF2\/HO1 Signaling in C9orf72-Associated ALS"],"prefix":"10.1007","volume":"28","author":[{"given":"Chao-Yi","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsuan\u2010Cheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010Ping","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddie Feng\u2010Ju","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1479-9100","authenticated-orcid":false,"given":"Shao\u2010Ming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"issue":"2","key":"8951_CR1","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.bbadis.2016.11.005","volume":"1863","author":"SM Ahmed","year":"2017","unstructured":"Ahmed, S. M., Luo, L., Namani, A., Wang, X. J., & Tang, X. (2017). Nrf2 signaling pathway: Pivotal roles in inflammation. Biochimica Et Biophysica Acta. Molecular Basis of Disease, 1863(2), 585\u2013597. https:\/\/doi.org\/10.1016\/j.bbadis.2016.11.005","journal-title":"Biochimica Et Biophysica Acta. Molecular Basis of Disease"},{"key":"8951_CR2","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202402853","author":"WH Au","year":"2024","unstructured":"Au, W. H., Miller-Fleming, L., Sanchez-Martinez, A., Lee, J. A., Twyning, M. J., Prag, H. A., Raik, L., Allen, S. P., Shaw, P. J., Ferraiuolo, L., Mortiboys, H., & Whitworth, A. J. (2024). Activation of the Keap1\/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS\/FTD models. Life Science Alliance. https:\/\/doi.org\/10.26508\/lsa.202402853","journal-title":"Life Science Alliance"},{"key":"8951_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10060981","author":"SR Barwick","year":"2021","unstructured":"Barwick, S. R., Siddiq, M. S., Wang, J., Xiao, H., Marshall, B., Perry, E., & Smith, S. B. (2021). Sigma 1 receptor co-localizes with NRF2 in retinal photoreceptor cells. Antioxidants. https:\/\/doi.org\/10.3390\/antiox10060981","journal-title":"Antioxidants"},{"key":"8951_CR4","doi-asserted-by":"publisher","unstructured":"Chang, Y. J., Lin, K. T., Shih, O., Yang, C. H., Chuang, C. Y., Fang, M. H., Lai, W. B., Lee, Y. C., Kuo, H. C., Hung, S. C., Yao, C. K., Jeng, U. S., & Chen, Y. R. (2024). Sulfated disaccharide protects membrane and DNA damages from arginine-rich dipeptide repeats in ALS. Sci Adv, 10(8), eadj0347. https:\/\/doi.org\/10.1126\/sciadv.adj0347","DOI":"10.1126\/sciadv.adj0347"},{"issue":"1","key":"8951_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0310-z","volume":"14","author":"J Chew","year":"2019","unstructured":"Chew, J., Cook, C., Gendron, T. F., Jansen-West, K., Del Rosso, G., Daughrity, L. M., Castanedes-Casey, M., Kurti, A., Stankowski, J. N., Disney, M. D., Rothstein, J. D., Dickson, D. W., Fryer, J. D., Zhang, Y. J., & Petrucelli, L. (2019). Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy. Molecular Neurodegeneration, 14(1), Article 9. https:\/\/doi.org\/10.1186\/s13024-019-0310-z","journal-title":"Molecular Neurodegeneration"},{"issue":"1","key":"8951_CR6","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.apsb.2024.10.004","volume":"15","author":"UC Dash","year":"2025","unstructured":"Dash, U. C., Bhol, N. K., Swain, S. K., Samal, R. R., Nayak, P. K., Raina, V., Panda, S. K., Kerry, R. G., Duttaroy, A. K., & Jena, A. B. (2025). Oxidative stress and inflammation in the pathogenesis of neurological disorders: Mechanisms and implications. Acta Pharmaceutica Sinica. B, 15(1), 15\u201334. https:\/\/doi.org\/10.1016\/j.apsb.2024.10.004","journal-title":"Acta Pharmaceutica Sinica. B"},{"issue":"848","key":"8951_CR7","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.adl1030","volume":"17","author":"D Dong","year":"2024","unstructured":"Dong, D., Zhang, Z., Li, Y., Latallo, M. J., Wang, S., Nelson, B., Wu, R., Krishnan, G., Gao, F. B., Wu, B., & Sun, S. (2024). Poly-GR repeats associated with ALS\/FTD gene C9ORF72 impair translation elongation and induce a ribotoxic stress response in neurons. Science Signaling, 17(848), Article eadl1030. https:\/\/doi.org\/10.1126\/scisignal.adl1030","journal-title":"Science Signaling"},{"issue":"1","key":"8951_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31098-6","volume":"13","author":"AM Gleixner","year":"2022","unstructured":"Gleixner, A. M., Verdone, B. M., Otte, C. G., Anderson, E. N., Ramesh, N., Shapiro, O. R., Gale, J. R., Mauna, J. C., Mann, J. R., Copley, K. E., Daley, E. L., Ortega, J. A., Cicardi, M. E., Kiskinis, E., Kofler, J., Pandey, U. B., Trotti, D., & Donnelly, C. J. (2022). NUP62 localizes to ALS\/FTLD pathological assemblies and contributes to TDP-43 insolubility. Nature Communications, 13(1), Article 3380. https:\/\/doi.org\/10.1038\/s41467-022-31098-6","journal-title":"Nature Communications"},{"issue":"3","key":"8951_CR9","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.cell.2007.08.036","volume":"131","author":"T Hayashi","year":"2007","unstructured":"Hayashi, T., & Su, T. P. (2007). Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival. Cell, 131(3), 596\u2013610. https:\/\/doi.org\/10.1016\/j.cell.2007.08.036","journal-title":"Cell"},{"key":"8951_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-026-01433-w","author":"WC Hsieh","year":"2026","unstructured":"Hsieh, W. C., Lin, C. Y., Wu, H. C., Weng, E. F., & Wang, S. M. (2026). Hyperoside protects against poly-GR-mediated neurodegeneration via regulation of mitochondrial fission and oxidative stress in C9orf72-associated ALS. Chinese Medicine. https:\/\/doi.org\/10.1186\/s13020-026-01433-w","journal-title":"Chinese Medicine"},{"issue":"3","key":"8951_CR11","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/s41419-019-1451-2","volume":"10","author":"A Ionescu","year":"2019","unstructured":"Ionescu, A., Gradus, T., Altman, T., Maimon, R., Saraf Avraham, N., Geva, M., Hayden, M., & Perlson, E. (2019). Targeting the Sigma-1 receptor via pridopidine ameliorates central features of ALS pathology in a SOD1(G93A) model. Cell Death & Disease, 10(3), 210. https:\/\/doi.org\/10.1038\/s41419-019-1451-2","journal-title":"Cell Death & Disease"},{"issue":"4","key":"8951_CR12","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.bpj.2020.07.005","volume":"119","author":"H Jafarinia","year":"2020","unstructured":"Jafarinia, H., van der Giessen, E., & Onck, P. R. (2020). Phase separation of toxic dipeptide repeat proteins related to C9orf72 ALS\/FTD. Biophysical Journal, 119(4), 843\u2013851. https:\/\/doi.org\/10.1016\/j.bpj.2020.07.005","journal-title":"Biophysical Journal"},{"key":"8951_CR13","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.89694","author":"H Jafarinia","year":"2024","unstructured":"Jafarinia, H., van der Giessen, E., & Onck, P. R. (2024). C9orf72 polyPR directly binds to various nuclear transport components. eLife. https:\/\/doi.org\/10.7554\/eLife.89694","journal-title":"eLife"},{"issue":"1-2","key":"8951_CR14","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.cell.2012.12.004","volume":"152","author":"S Kourrich","year":"2013","unstructured":"Kourrich, S., Hayashi, T., Chuang, J. Y., Tsai, S. Y., Su, T. P., & Bonci, A. (2013). Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine. Cell, 152(1\u20132), 236\u2013247. https:\/\/doi.org\/10.1016\/j.cell.2012.12.004","journal-title":"Cell"},{"key":"8951_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102542","volume":"58","author":"C Lasbleiz","year":"2022","unstructured":"Lasbleiz, C., Peyrel, A., Tarot, P., Sarniguet, J., Crouzier, L., Cubedo, N., Delprat, B., Rossel, M., Maurice, T., & Lievens, J. C. (2022). Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling. Redox Biology, 58, Article 102542. https:\/\/doi.org\/10.1016\/j.redox.2022.102542","journal-title":"Redox Biology"},{"issue":"1","key":"8951_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-025-00527-z","volume":"14","author":"J Le Friec","year":"2025","unstructured":"Le Friec, J., Mourier, H., Couly, S., Cubedo, N., Dubois, K., Meunier, J., Delprat, B., De Zordo-Banliat, A., Ayad, T., Virieux, D., Su, T. P., Lasbleiz, C., Maurice, T., & Lievens, J. C. (2025). Positive modulation of sigma-1 receptor: A new weapon to mitigate disease progression in amyotrophic lateral sclerosis. Translational Neurodegeneration, 14(1), Article 68. https:\/\/doi.org\/10.1186\/s40035-025-00527-z","journal-title":"Translational Neurodegeneration"},{"key":"8951_CR17","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-026-01574-3","author":"CY Lin","year":"2026","unstructured":"Lin, C. Y., Hsieh, W. C., & Wang, S. M. (2026). Poly-GR promotes ferroptosis-associated vulnerability in C9orf72-ALS. Cellular and Molecular Biosciences. https:\/\/doi.org\/10.1186\/s13578-026-01574-3","journal-title":"Cellular and Molecular Biosciences"},{"key":"8951_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2025.106992","volume":"212","author":"CY Lin","year":"2025","unstructured":"Lin, C. Y., Wu, H. C., Fu, R. H., Weng, E. F., Hsieh, W. C., Su, T. P., Wu, H. E., & Wang, S. M. (2025). Sigma-1R-Pom121 axis preserves nuclear transport and integrity in poly-PR-induced C9orf72 ALS. Neurobiology of Disease, 212, Article 106992. https:\/\/doi.org\/10.1016\/j.nbd.2025.106992","journal-title":"Neurobiology of Disease"},{"issue":"8","key":"8951_CR19","doi-asserted-by":"publisher","first-page":"5282","DOI":"10.1007\/s12035-023-03885-9","volume":"61","author":"CY Lin","year":"2024","unstructured":"Lin, C. Y., Wu, H. E., Weng, E. F., Wu, H. C., Su, T. P., & Wang, S. M. (2024). Fluvoxamine exerts Sigma-1R to rescue autophagy via Pom121-mediated nucleocytoplasmic transport of TFEB. Molecular Neurobiology, 61(8), 5282\u20135294. https:\/\/doi.org\/10.1007\/s12035-023-03885-9","journal-title":"Molecular Neurobiology"},{"issue":"17","key":"8951_CR20","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","volume":"73","author":"A Loboda","year":"2016","unstructured":"Loboda, A., Damulewicz, M., Pyza, E., Jozkowicz, A., & Dulak, J. (2016). Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: An evolutionarily conserved mechanism. Cellular and Molecular Life Sciences, 73(17), 3221\u20133247. https:\/\/doi.org\/10.1007\/s00018-016-2223-0","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"7","key":"8951_CR21","doi-asserted-by":"publisher","first-page":"e1332","DOI":"10.1038\/cddis.2014.301","volume":"5","author":"T Omi","year":"2014","unstructured":"Omi, T., Tanimukai, H., Kanayama, D., Sakagami, Y., Tagami, S., Okochi, M., Morihara, T., Sato, M., Yanagida, K., Kitasyoji, A., Hara, H., Imaizumi, K., Maurice, T., Chevallier, N., Marchal, S., Takeda, M., & Kudo, T. (2014). Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor. Cell Death & Disease, 5(7), e1332. https:\/\/doi.org\/10.1038\/cddis.2014.301","journal-title":"Cell Death & Disease"},{"issue":"1\u20133","key":"8951_CR22","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ejphar.2012.01.030","volume":"682","author":"A Pal","year":"2012","unstructured":"Pal, A., Fontanilla, D., Gopalakrishnan, A., Chae, Y. K., Markley, J. L., & Ruoho, A. E. (2012). The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements. European Journal of Pharmacology, 682(1\u20133), 12\u201320. https:\/\/doi.org\/10.1016\/j.ejphar.2012.01.030","journal-title":"European Journal of Pharmacology"},{"issue":"8","key":"8951_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112822","volume":"42","author":"J Park","year":"2023","unstructured":"Park, J., Wu, Y., Shao, W., Gendron, T. F., van der Spek, S. J. F., Sultanakhmetov, G., Basu, A., Castellanos Otero, P., Jones, C. J., Jansen-West, K., Daughrity, L. M., Phanse, S., Del Rosso, G., Tong, J., Castanedes-Casey, M., Jiang, L., Libera, J., Oskarsson, B., Dickson, D. W., \u2026 Zhang, Y. J. (2023). Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions. Cell Reports, 42(8), Article 112822. https:\/\/doi.org\/10.1016\/j.celrep.2023.112822","journal-title":"Cell Reports"},{"key":"8951_CR24","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/956792","volume":"2013","author":"B Poljsak","year":"2013","unstructured":"Poljsak, B., Suput, D., & Milisav, I. (2013). Achieving the balance between ROS and antioxidants: When to use the synthetic antioxidants. Oxidative Medicine and Cellular Longevity, 2013, Article 956792. https:\/\/doi.org\/10.1155\/2013\/956792","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"8951_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.925879","volume":"13","author":"P Ren","year":"2022","unstructured":"Ren, P., Wang, J., Li, N., Li, G., Ma, H., Zhao, Y., & Li, Y. (2022). Sigma-1 receptors in depression: Mechanism and therapeutic development. Frontiers in Pharmacology, 13, Article 925879. https:\/\/doi.org\/10.3389\/fphar.2022.925879","journal-title":"Frontiers in Pharmacology"},{"issue":"12","key":"8951_CR26","doi-asserted-by":"publisher","first-page":"10318","DOI":"10.1007\/s12035-024-04187-4","volume":"61","author":"J Sultana","year":"2024","unstructured":"Sultana, J., Ragagnin, A. M. G., Parakh, S., Saravanabavan, S., Soo, K. Y., Vidal, M., Jagaraj, C. J., Ding, K., Wu, S., Shadfar, S., Don, E. K., Deva, A., Nicholson, G., Rowe, D. B., Blair, I., Yang, S., & Atkin, J. D. (2024). C9orf72-associated dipeptide repeat expansions perturb ER-Golgi vesicular trafficking, inducing Golgi fragmentation and ER stress, in ALS\/FTD. Molecular Neurobiology, 61(12), 10318\u201310338. https:\/\/doi.org\/10.1007\/s12035-024-04187-4","journal-title":"Molecular Neurobiology"},{"issue":"9","key":"8951_CR27","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1093\/hmg\/ddv005","volume":"24","author":"Z Tao","year":"2015","unstructured":"Tao, Z., Wang, H., Xia, Q., Li, K., Li, K., Jiang, X., Xu, G., Wang, G., & Ying, Z. (2015). Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity. Human Molecular Genetics, 24(9), 2426\u20132441. https:\/\/doi.org\/10.1093\/hmg\/ddv005","journal-title":"Human Molecular Genetics"},{"issue":"47","key":"8951_CR28","doi-asserted-by":"publisher","first-page":"E6562","DOI":"10.1073\/pnas.1518894112","volume":"112","author":"SY Tsai","year":"2015","unstructured":"Tsai, S. Y., Chuang, J. Y., Tsai, M. S., Wang, X. F., Xi, Z. X., Hung, J. J., Chang, W. C., Bonci, A., & Su, T. P. (2015). Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope. Proceedings of the National Academy of Sciences of the United States of America, 112(47), E6562-6570. https:\/\/doi.org\/10.1073\/pnas.1518894112","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"50","key":"8951_CR29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2402847121","volume":"121","author":"M Van Nerom","year":"2024","unstructured":"Van Nerom, M., Ahmed, J., Lazar, T., Meszaros, A., Galand, Q., De Malsche, W., Van Lindt, J., Pancsa, R., Maes, D., & Tompa, P. (2024). C9orf72-linked arginine-rich dipeptide repeats aggravate pathological phase separation of G3BP1. Proceedings of the National Academy of Sciences of the United States of America, 121(50), Article e2402847121. https:\/\/doi.org\/10.1073\/pnas.2402847121","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"8951_CR30","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.freeradbiomed.2019.02.001","volume":"134","author":"J Wang","year":"2019","unstructured":"Wang, J., Zhao, J., Cui, X., Mysona, B. A., Navneet, S., Saul, A., Ahuja, M., Lambert, N., Gazaryan, I. G., Thomas, B., Bollinger, K. E., & Smith, S. B. (2019). The molecular chaperone sigma 1 receptor mediates rescue of retinal cone photoreceptor cells via modulation of NRF2. Free Radical Biology & Medicine, 134, 604\u2013616. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2019.02.001","journal-title":"Free Radical Biology & Medicine"},{"issue":"1","key":"8951_CR31","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1080\/15548627.2022.2063003","volume":"19","author":"SM Wang","year":"2023","unstructured":"Wang, S. M., Wu, H. E., Yasui, Y., Geva, M., Hayden, M., Maurice, T., Cozzolino, M., & Su, T. P. (2023). Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1\/sigma-1 receptor chaperone by pridopidine. Autophagy, 19(1), 126\u2013151. https:\/\/doi.org\/10.1080\/15548627.2022.2063003","journal-title":"Autophagy"},{"issue":"1","key":"8951_CR32","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s12929-017-0380-6","volume":"24","author":"TY Weng","year":"2017","unstructured":"Weng, T. Y., Tsai, S. A., & Su, T. P. (2017). Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases. Journal of Biomedical Science, 24(1), 74. https:\/\/doi.org\/10.1186\/s12929-017-0380-6","journal-title":"Journal of Biomedical Science"},{"key":"8951_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103875","volume":"87","author":"HC Wu","year":"2025","unstructured":"Wu, H. C., Huang, T. W., Weng, E. F., Lin, C. Y., Su, T. P., Wu, H. E., & Wang, S. M. (2025). Sigma-1 receptor counteracts non-cell-autonomous poly-PR-induced astrocytic oxidative stress in C9orf72 ALS. Redox Biology, 87, Article 103875. https:\/\/doi.org\/10.1016\/j.redox.2025.103875","journal-title":"Redox Biology"},{"key":"8951_CR34","doi-asserted-by":"publisher","unstructured":"Zhang, Z., Fu, X., Wright, N., Wang, W., Ye, Y., Asbury, J., Li, Y., Zhu, C., Wu, R., Wang, S., & Sun, S. (2025). PTPsigma-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS\/FTD. Neuron, 113(8), 1190\u20131205 e1199. https:\/\/doi.org\/10.1016\/j.neuron.2025.02.005","DOI":"10.1016\/j.neuron.2025.02.005"}],"container-title":["NeuroMolecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-026-08951-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12017-026-08951-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12017-026-08951-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T18:09:46Z","timestamp":1791742186000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12017-026-08951-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,11]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["8951"],"URL":"https:\/\/doi.org\/10.1007\/s12017-026-08951-8","relation":{},"ISSN":["1559-1174"],"issn-type":[{"value":"1559-1174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,11]]},"assertion":[{"value":"3 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"During manuscript preparation, the authors used ChatGPT for language editing. All content was carefully reviewed and revised by the authors, who take full responsibility for the final version of the publication.","order":3,"name":"Ethics","label":"Declaration of Generative AI and AI-Assisted Technologies","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal procedures were performed in compliance with the ethical guidelines and regulations approved by the Institutional Animal Care and Use Committee (IACUC) of China Medical University (Protocol No. CMUIACUC-2025-007) and adhered to the Guide for the Care and Use of Laboratory Animals. Clinical trial registration: not applicable.","order":4,"name":"Ethics","label":"Ethics Approval and Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"54"}}