{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:53:30Z","timestamp":1777031610666,"version":"3.51.4"},"reference-count":166,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T00:00:00Z","timestamp":1353456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1007\/s12020-012-9835-4","type":"journal-article","created":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T16:45:23Z","timestamp":1353602723000},"page":"514-528","source":"Crossref","is-referenced-by-count":46,"title":["Therapy of adrenal insufficiency: an update"],"prefix":"10.1007","volume":"43","author":[{"given":"Alberto","family":"Falorni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Minarelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Morelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,11,21]]},"reference":[{"key":"9835_CR1","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1056\/NEJM199610173351607","volume":"335","author":"W Oelkers","year":"1996","unstructured":"W. Oelkers, Adrenal insufficiency. N. Engl. J. Med. 335, 1206\u20131212 (1996)","journal-title":"N. Engl. J. Med."},{"key":"9835_CR2","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1210\/jc.86.7.2909","volume":"86","author":"S Ten","year":"2001","unstructured":"S. Ten, M. New, N. Maclaren, Clinical review 130: Addison\u2019s disease 2001. J. Clin. Endocrinol. Metab. 86, 2909\u20132922 (2001)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR3","unstructured":"T. Addison, On the constitutional and local effects of disease of the supra-renal capsules. 1855. Reproduced in Dr. Addison\u2019s works. New Sydenham Soc. 36, 211\u2013239 (1868)"},{"key":"9835_CR4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1530\/eje.0.1370010","volume":"137","author":"P Aubourg","year":"1997","unstructured":"P. Aubourg, The expanding world of primary adrenal insufficiencies. Eur. J. Endocrinol. 137, 10\u201312 (1997)","journal-title":"Eur. J. Endocrinol."},{"key":"9835_CR5","first-page":"251","volume":"2","author":"S Laureti","year":"2002","unstructured":"S. Laureti, F. Santeusanio, A. Falorni, Recent advances in the diagnosis and therapy of primary adrenal insufficiency. Curr. Med. Chem. 2, 251\u2013258 (2002)","journal-title":"Curr. Med. Chem."},{"key":"9835_CR6","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0140-6736(68)90948-3","volume":"II","author":"AS Mason","year":"1968","unstructured":"A.S. Mason, T.W. Meade, J.A.H. Lee, J.N. Morris, Epidemiological and clinical picture of Addison\u2019s disease. Lancet II, 744\u2013747 (1968)","journal-title":"Lancet"},{"key":"9835_CR7","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1530\/acta.0.0760127","volume":"76","author":"J Nerup","year":"1974","unstructured":"J. Nerup, Addison\u2019s disease\u2014clinical studies. A report of 108 cases. Acta Endocrinol. (Copenh.) 76, 127\u2013141 (1974)","journal-title":"Acta Endocrinol. (Copenh.)"},{"key":"9835_CR8","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1210\/jc.84.5.1762","volume":"84","author":"S Laureti","year":"1999","unstructured":"S. Laureti, L. Vecchi, F. Santeusanio, A. Falorni, Is the prevalence of Addison\u2019s disease underestimated? J. Clin. Endocrinol. Metab. 84, 1762 (1999)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR9","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.1365-2265.1994.tb02790.x","volume":"41","author":"MF Kong","year":"1994","unstructured":"M.F. Kong, W. Jeffcoate, Eighty-six cases of Addison\u2019s disease. Clin. Endocrinol. (Oxf.) 41, 757\u2013761 (1994)","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"9835_CR10","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1136\/pgmj.73.859.286","volume":"73","author":"AC Willis","year":"1997","unstructured":"A.C. Willis, F.P. Vince, The prevalence of Addison\u2019s disease in Coventry, UK. Postgrad. Med. J. 73, 286\u2013288 (1997)","journal-title":"Postgrad. Med. J."},{"key":"9835_CR11","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1046\/j.1365-2265.2002.t01-1-01552.x","volume":"56","author":"K L\u00f8vas","year":"2002","unstructured":"K. L\u00f8vas, E.S. Husebye, High prevalence and increasing incidence of Addison\u2019s disease in western Norway. Clin. Endocrinol. (Oxf.) 56, 787\u2013791 (2002)","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"9835_CR12","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1210\/er.23.3.327","volume":"23","author":"C Betterle","year":"2002","unstructured":"C. Betterle, C. Dal Pra, F. Mantero, R. Zanchetta, Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction. Endocr. Rev. 23, 327\u2013364 (2002)","journal-title":"Endocr. Rev."},{"key":"9835_CR13","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1586\/eem.09.20","volume":"4","author":"A Falorni","year":"2009","unstructured":"A. Falorni, A. Brozzetti, F. Calcinaro, S. Marzotti, F. Santeusanio, Recent advances in adrenal autoimmunity. Expert Rev. Clin. Endocrinol. Metab. 4, 333\u2013348 (2009)","journal-title":"Expert Rev. Clin. Endocrinol. Metab."},{"key":"9835_CR14","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/0140-6736(92)91829-W","volume":"339","author":"O Winqvist","year":"1992","unstructured":"O. Winqvist, F.A. Karlsson, O. K\u00e4mpe, 21-Hydroxylase, a major autoantigen in idiopathic Addison\u2019s disease. Lancet 339, 1559\u20131562 (1992)","journal-title":"Lancet"},{"key":"9835_CR15","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0140-6736(92)91513-8","volume":"340","author":"A Baumann-Antczak","year":"1992","unstructured":"A. Baumann-Antczak, N. Wedlock, J. Bednarek, Y. Kiso, H. Krishnan, S. Fowler, B. Rees Smith, J. Furmaniak, Autoimmune Addison\u2019s disease and 21-hydroxylase. Lancet 340, 429\u2013430 (1992)","journal-title":"Lancet"},{"key":"9835_CR16","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0014-5793(92)80737-2","volume":"309","author":"J Bednarek","year":"1992","unstructured":"J. Bednarek, J. Furmaniak, N. Wedlock, Y. Kiso, A. Baumann-Antczak, S. Fowler, H. Krishnan, J.A. Craft, B. Rees Smith, Steroid 21-hydroxylase is a major autoantigen involved in adult onset autoimmune Addison\u2019s disease. FEBS Lett. 309, 51\u201355 (1992)","journal-title":"FEBS Lett."},{"key":"9835_CR17","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1210\/jc.80.9.2752","volume":"80","author":"A Falorni","year":"1995","unstructured":"A. Falorni, A. Nikoshkov, S. Laureti et al., High diagnostic accuracy for idiopathic Addison\u2019s disease with a sensitive radiobinding assay for autoantibodies against recombinant human 21-hydroxylase. J. Clin. Endocrinol. Metab. 80, 2752\u20132755 (1995)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR18","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/clinchem\/41.3.375","volume":"41","author":"J Colls","year":"1995","unstructured":"J. Colls, C. Betterle, M. Volpato, L. Prentice, B.R. Smith, J. Furmaniak, Immunoprecipitation assay for autoantibodies to steroid 21-hydroxylase in autoimmune adrenal diseases. Clin. Chem. 41, 375\u2013380 (1995)","journal-title":"Clin. Chem."},{"key":"9835_CR19","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1210\/jc.82.5.1440","volume":"82","author":"H Tanaka","year":"1997","unstructured":"H. Tanaka, M.S. Perez, M. Powell et al., Steroid 21-hydroxylase autoantibodies: measurements with a new immunoprecipitation assay. J. Clin. Endocrinol. Metab. 82, 1440\u20131446 (1997)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR20","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1046\/j.1365-2265.2003.01889.x","volume":"59","author":"R Nigam","year":"2003","unstructured":"R. Nigam, E. Bhatia, D. Mei, L. Yu, A. Brozzetti, G.S. Eisenbarth, A. Falorni, Low prevalence of 21-hydroxylase antibodies in idiopathic Addison\u2019s disease from India. Clin. Endocrinol. 59, 593\u2013598 (2003)","journal-title":"Clin. Endocrinol."},{"key":"9835_CR21","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/BF03351067","volume":"27","author":"F Kelestimur","year":"2004","unstructured":"F. Kelestimur, The endocrinology of adrenal tuberculosis: the effects of tuberculosis on the hypothalamo-pituitary-adrenal axis and adrenocortical function. J. Endocrinol. Invest. 27, 380\u2013386 (2004)","journal-title":"J. Endocrinol. Invest."},{"key":"9835_CR22","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1023\/A:1022583813171","volume":"24","author":"P Aubourg","year":"1999","unstructured":"P. Aubourg, On the front of X-linked adrenoleukodystrophy. Neurochem. Res. 24, 515\u2013520 (1999)","journal-title":"Neurochem. Res."},{"key":"9835_CR23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.mce.2006.12.017","volume":"265\u2013266","author":"ER McCabe","year":"2007","unstructured":"E.R. McCabe, DAX1: increasing complexity in the roles of this novel nuclear receptor. Mol. Cell. Endocrinol. 265\u2013266, 179\u2013182 (2007)","journal-title":"Mol. Cell. Endocrinol."},{"key":"9835_CR24","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/9629","volume":"22","author":"JC Achermann","year":"1999","unstructured":"J.C. Achermann, M. Ito, M. Ito, P.C. Hindmarsch, J.L. Jameson, A mutation in the gene encoding steroidogenic factor-1 causes XY sex reversal and adrenal failure in humans. Nat. Genet. 22, 125\u2013126 (1999)","journal-title":"Nat. Genet."},{"key":"9835_CR25","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0140-6736(93)90208-X","volume":"341","author":"AJ Clark","year":"1993","unstructured":"A.J. Clark, L. McLoughlin, A. Grossman, Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor. Lancet 341, 461\u2013462 (1993)","journal-title":"Lancet"},{"key":"9835_CR26","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1093\/hmg\/5.12.2061","volume":"5","author":"A Weber","year":"1996","unstructured":"A. Weber, T.F. Wienker, M. Jung, D. Easton, H.J. Dean, C. Heinrichs, A. Reis, A.J. Clark, Linkage of the gene for the triple A syndrome to chromosome 12q13 near the type II keratin gene cluster. Hum. Mol. Genet. 5, 2061\u20132066 (1996)","journal-title":"Hum. Mol. Genet."},{"key":"9835_CR27","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0022-3476(96)80136-3","volume":"128","author":"K North","year":"1996","unstructured":"K. North, M.S. Korson, N. Krawiecki, J.M. Shoffner, I.A. Holm, Oxidative phosphorylation defect associated with primary adrenal insufficiency. J. Pediatrics 128, 688\u2013692 (1996)","journal-title":"J. Pediatrics"},{"key":"9835_CR28","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/(SICI)1096-8628(19990219)82:5<382::AID-AJMG5>3.0.CO;2-9","volume":"82","author":"HC Andersson","year":"1999","unstructured":"H.C. Andersson, J. Frentz, J.E. Mart\u00ednez, C.M. Tuck-Muller, J. Bellizaire, Adrenal insufficiency in Smith-Lemli-Opitz syndrome. Am. J. Med. Genet. 82, 382\u2013384 (1999)","journal-title":"Am. J. Med. Genet."},{"key":"9835_CR29","first-page":"4602","volume":"92","author":"R Perry","year":"2005","unstructured":"R. Perry, O. Kecha, J. Paquette, C. Huot, G. Van Vliet, C. Deal, Primary adrenal insufficiency in children: twenty years experience at the Sainte-Justine Hospital, Montreal. J. Clin. Endocrinol. Metab. 92, 4602\u20134608 (2005)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR30","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1677\/joe.0.1170467","volume":"117","author":"C Betterle","year":"1988","unstructured":"C. Betterle, C. Scalici, F. Presotto et al., The natural history of adrenal function in autoimmune patients with adrenal autoantibodies. J. Endocrinol. 117, 467\u2013475 (1988)","journal-title":"J. Endocrinol."},{"key":"9835_CR31","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1210\/jc.76.4.1002","volume":"76","author":"A Bellis De","year":"1993","unstructured":"A. De Bellis, A. Bizzarro, R. Rossi, V.A. Paglionico, T. Criscuolo, G. Lombardi, A. Bellastella, Remission of subclinical adrenocortical failure in subjects with adrenal autoantibodies. J. Clin. Endocrinol. Metab. 76, 1002\u20131007 (1993)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR32","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1210\/jc.82.3.932","volume":"82","author":"C Betterle","year":"1997","unstructured":"C. Betterle, M. Volpato, B. Rees-Smith et al., I. Adrenal cortex and steroid 21-hydroxylase autoantibodies in adult patients with organ-specific autoimmune diseases: markers of low progression to clinical Addison\u2019s disease. J. Clin. Endocrinol. Metab. 82, 932\u2013938 (1997)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR33","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1210\/jc.82.3.939","volume":"82","author":"C Betterle","year":"1997","unstructured":"C. Betterle, M. Volpato, B. Rees Smith, J. Furmaniak, S. Chen, R. Zanchetta, N.A. Greggio, B. Pedini, M. Boscaro, F. Presotto II, Adrenal cortex and steroid 21-hydroxylase autoantibodies in children with organ-specific autoimmune diseases: markers of high progression to clinical Addison\u2019s disease. J. Clin. Endocrinol. Metab. 82, 939\u2013942 (1997)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR34","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1210\/jc.83.10.3507","volume":"83","author":"S Laureti","year":"1998","unstructured":"S. Laureti, A. De Bellis, V.I. Muccitelli et al., Levels of adrenocortical autoantibodies correlate with the degree of adrenal dysfunction in subjects with preclinical Addison\u2019s disease. J. Clin. Endocrinol. Metab. 83, 3507\u20133511 (1998)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR35","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1210\/jc.2005-0860","volume":"91","author":"G Coco","year":"2006","unstructured":"G. Coco, C. Dal Pra, F. Presotto et al., Estimated risk for developing autoimmune Addison\u2019s disease in patients with adrenal cortex autoantibodies. J. Clin. Endocrinol. Metab. 91, 1637\u20131645 (2006)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR36","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1055\/s-0030-1268457","volume":"42","author":"B Jacobs","year":"2010","unstructured":"B. Jacobs, C. Papewalis, M. Ehlers, M. Schott, Endocrine organs under the control of the immune system: potential implications for cellular therapies. Horm. Metab. Res. 42, 912\u2013917 (2010)","journal-title":"Horm. Metab. Res."},{"key":"9835_CR37","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1530\/acta.0.1220472","volume":"122","author":"KI Papadopoulos","year":"1990","unstructured":"K.I. Papadopoulos, B. Hallengren, Polyglandular autoimmune syndrome type II in patients with idiopathic Addison\u2019s disease. Acta Endocrinol. (Copenh.) 122, 472\u2013478 (1990)","journal-title":"Acta Endocrinol. (Copenh.)"},{"key":"9835_CR38","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1136\/pgmj.67.793.984","volume":"67","author":"AA Kasperlik-Zaluska","year":"1991","unstructured":"A.A. Kasperlik-Zaluska, B. Migdalska, B. Czarnocka, J. Drac-Kaniewska, E. Niegowska, W. Czech, Association of Addison\u2019s disease with autoimmune disorders\u2014a long-term observation of 180 patients. Postgrad. Med. J. 67, 984\u2013987 (1991)","journal-title":"Postgrad. Med. J."},{"key":"9835_CR39","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/jaut.1995.0009","volume":"8","author":"PM Zelissen","year":"1995","unstructured":"P.M. Zelissen, E.J. Bast, R.J. Croughs, Associated autoimmunity in Addison\u2019s disease. J. Autoimmunity 8, 121\u2013130 (1995)","journal-title":"J. Autoimmunity"},{"key":"9835_CR40","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/GCO.0b013e32833b6c70","volume":"22","author":"A Marca La","year":"2010","unstructured":"A. La Marca, A. Brozzetti, G. Sighinolfi, S. Marzotti, A. Volpe, A. Falorni, Primary ovarian insufficiency: autoimmune causes. Curr. Opin. Obstet. Gynecol. 22, 277\u2013282 (2010)","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"9835_CR41","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1056\/NEJMra030158","volume":"350","author":"GS Eisenbarth","year":"2004","unstructured":"G.S. Eisenbarth, P.A. Gottlieb, Autoimmune polyendocrine syndromes. N. Engl. J. Med. 350, 2068\u20132079 (2004)","journal-title":"N. Engl. J. Med."},{"key":"9835_CR42","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1365-2249.2004.02384.x","volume":"135","author":"P Peterson","year":"2004","unstructured":"P. Peterson, J. Pitk\u00e4nen, N. Sillanp\u00e4\u00e4, K. Krohn, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED): a model disease to study molecular aspects of endocrine autoimmunity. Clin. Exp. Immunol. 135, 348\u2013357 (2004)","journal-title":"Clin. Exp. Immunol."},{"key":"9835_CR43","doi-asserted-by":"crossref","first-page":"e289","DOI":"10.1371\/journal.pmed.0030289","volume":"3","author":"A Meager","year":"2006","unstructured":"A. Meager, K. Visvalingam, P. Peterson, K. M\u00f6ll, A. Murum\u00e4gi, K. Krohn, P. Eskelin, J. Perheentupa, E. Husebye, Y. Kadota, N. Willcox, Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1. PLoS Med. 3, e289 (2006)","journal-title":"PLoS Med."},{"key":"9835_CR44","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1210\/jc.2008-0935","volume":"93","author":"A Meloni","year":"2008","unstructured":"A. Meloni, M. Furcas, F. Cetani, C. Marcocci, A. Falorni, R. Perniola, M. Pura, A.S. B\u00f8e Wolff, E. Husebye, D. Lilic, K.R. Ryan, A.R. Gennery, A.J. Cant, M. Abinun, G.P. Spickett, P.D. Arkwright, D. Denning, C. Costigan, M. Dominguez, V. McConnell, N. Willcox, A. Meager, Autoantibodies against type I Interferons as an additional diagnostic criteria for Autoimmune Polyendocrine Syndrome type 1. J. Clin. Endocrinol. Metab. 93, 4389\u20134397 (2008)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR45","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1586\/1744666X.4.4.441","volume":"4","author":"A Falorni","year":"2008","unstructured":"A. Falorni, A. Brozzetti, D. La Torre, C. Tortoioli, G. Gambelunghe, The association of genetic polymorphisms and autoimmune Addison\u2019s disease. Expert Rev. Clin. Immunol. 4, 441\u2013456 (2008)","journal-title":"Expert Rev. Clin. Immunol."},{"key":"9835_CR46","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1210\/jc.2009-2631","volume":"95","author":"PW Speiser","year":"2010","unstructured":"P.W. Speiser, R. Azziz, L.S. Baskin, L. Ghizzoni, T.W. Hensle, D.P. Merke, H.F. Meyer-Bahlburg, W.L. Miller, V.M. Montori, S.E. Oberfield, M. Ritzen, P.C. White, Endocrine Society. Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 95, 4133\u20134160 (2010)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR47","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000082896","volume":"63","author":"A Nordenstr\u00f6m","year":"2005","unstructured":"A. Nordenstr\u00f6m, S. Ahmed, J. Jones, M. Coleman, D.A. Price, P.E. Clayton, C.M. Hall, Female preponderance in congenital adrenal hyperplasia due to CYP21 deficiency in England: implications for neonatal screening. Horm. Res. 63, 22\u201328 (2005)","journal-title":"Horm. Res."},{"key":"9835_CR48","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/00008480-199708000-00018","volume":"9","author":"S Pang","year":"1997","unstructured":"S. Pang, M.K. Shook, Current status of neonatal screening for congenital adrenal hyperplasia. Curr. Opin. Pediatr. 9, 419\u2013423 (1997)","journal-title":"Curr. Opin. Pediatr."},{"key":"9835_CR49","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0889-8529(08)70017-3","volume":"30","author":"BL Therrell","year":"2001","unstructured":"B.L. Therrell, Newborn screening for congenital adrenal hyperplasia. Endocrinol. Metab. Clin. North Am. 30, 15\u201330 (2001)","journal-title":"Endocrinol. Metab. Clin. North Am."},{"issue":"Suppl 3","key":"9835_CR50","doi-asserted-by":"crossref","first-page":"U71","DOI":"10.1530\/eje.0.151U071","volume":"151","author":"HJ Kamp van der","year":"2004","unstructured":"H.J. van der Kamp, J.M. Wit, Neonatal screening for congenital adrenal hyperplasia. Eur. J. Endocrinol. 151(Suppl 3), U71\u2013U75 (2004)","journal-title":"Eur. J. Endocrinol."},{"key":"9835_CR51","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11102-008-0108-4","volume":"11","author":"G Reimondo","year":"2008","unstructured":"G. Reimondo, S. Bovio, B. Allasino, M. Terzolo, A. Angeli, Secondary hypoadrenalism. Pituitary 11, 147\u2013154 (2008)","journal-title":"Pituitary"},{"key":"9835_CR52","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1210\/er.2004-0011","volume":"26","author":"P Caturegli","year":"2005","unstructured":"P. Caturegli, C. Newschaffer, A. Olivi, M.G. Pomper, P.C. Burger, N.R. Rose, Auutoimmune hypophysitis. Endocr. Rev. 26, 599\u2013614 (2005)","journal-title":"Endocr. Rev."},{"key":"9835_CR53","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMra020529","volume":"348","author":"MS Cooper","year":"2003","unstructured":"M.S. Cooper, P.M. Stewart, Corticosteroid insufficiency in acutely ill patients. N. Engl. J. Med. 348, 727\u2013734 (2003)","journal-title":"N. Engl. J. Med."},{"key":"9835_CR54","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1210\/jc.85.9.3141","volume":"85","author":"E Arvat","year":"2000","unstructured":"E. Arvat, L. Di Vito, F. Lanfranco, M. Maccario, C. Baffoni, R. Rossetto, G. Aimaretti, F. Camanni, E. Ghigo, Stimulatory effect of adrenocorticotropin on cortisol, aldosterone, and dehydroepiandrosterone secretion in normal humans: dose-response study. J. Clin. Endocrinol. Metab. 85, 3141\u20133146 (2000)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR55","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1046\/j.1365-2265.2000.01050.x","volume":"53","author":"S Laureti","year":"2000","unstructured":"S. Laureti, E. Arvat, P. Candeloro, L. Di Vito, E. Ghigo, F. Santeusanio, A. Falorni, Low dose (1 microg) ACTH test in the evaluation of adrenal dysfunction in pre-clinical Addison\u2019s disease. Clin. Endocrinol. (Oxf.) 53, 107\u2013115 (2000)","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"9835_CR56","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1046\/j.1365-2265.2002.01651.x","volume":"57","author":"S Laureti","year":"2002","unstructured":"S. Laureti, P. Candeloro, M.C. Aglietti, R. Giordano, E. Arvat, E. Ghigo, F. Santeusanio, A. Falorni, Dehydroepiandrosterone, 17alpha-hydroxyprogesterone and aldosterone responses to the low-dose (1 micro g) ACTH test in subjects with preclinical adrenal autoimmunity. Clin. Endocrinol. (Oxf.) 57, 677\u2013683 (2002)","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"9835_CR57","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1210\/jc.2003-030954","volume":"89","author":"A Falorni","year":"2004","unstructured":"A. Falorni, S. Laureti, A. De Bellis et al., Italian Addison Network Study: update of diagnostic criteria for the etiological classification of primary adrenal insufficiency. J. Clin. Endocrinol. Metab. 89, 1598\u20131604 (2004)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR58","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1210\/jc.83.9.3163","volume":"83","author":"S Laureti","year":"1998","unstructured":"S. Laureti, P. Aubourg, F. Calcinaro, F. Rocchiccioli, G. Casucci, G. Angeletti, P. Brunetti, \u00c5. Lernmark, F. Santeusanio, A. Falorni, Etiological diagnosis of primary adrenal insufficiency using an original flow-chart of immune and biochemical markers. J. Clin. Endocrinol. Metab. 83, 3163\u20133168 (1998)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR59","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1365-2796.2009.02090.x","volume":"265","author":"ES Husebye","year":"2009","unstructured":"E.S. Husebye, J. Perheentupa, R. Rautemaa, O. K\u00e4mpe, Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I. J. Intern. Med. 265, 514\u2013529 (2009)","journal-title":"J. Intern. Med."},{"key":"9835_CR60","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0015-0282(02)03205-3","volume":"78","author":"A Falorni","year":"2002","unstructured":"A. Falorni, S. Laureti, P. Candeloro et al., Steroid-cell autoantibodies are preferentially expressed in women with premature ovarian failure who have adrenal autoimmunity. Fertil. Steril. 78, 270\u2013279 (2002)","journal-title":"Fertil. Steril."},{"key":"9835_CR61","doi-asserted-by":"crossref","first-page":"E1255","DOI":"10.1210\/jc.2011-0414","volume":"96","author":"G Reato","year":"2011","unstructured":"G. Reato, L. Morlin, S. Chen, J. Furmaniak, B.R. Smith, S. Masiero, M.P. Albergoni, S. Cervato, R. Zanchetta, C. Betterle, Premature ovarian failure in patients with autoimmune Addison\u2019s disease: clinical, genetic, and immunological evaluation. J. Clin. Endocrinol. Metab. 96, E1255\u2013E1261 (2011)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR62","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.clim.2011.04.012","volume":"140","author":"A Falorni","year":"2011","unstructured":"A. Falorni, S. Chen, R. Zanchetta, L. Yu, C. Tiberti, M.L. Bacosi, J. Furmaniak, V. Bini, F. Dotta, G.S. Eisenbarth, B.R. Smith, C. Betterle, Measuring adrenal autoantibody response: interlaboratory concordance in the first international serum exchange for the determination of 21-hydroxylase autoantibodies. Clin. Immunol. 140, 291\u2013299 (2011)","journal-title":"Clin. Immunol."},{"key":"9835_CR63","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1517\/14656566.4.12.2145","volume":"4","author":"K Lovas","year":"2003","unstructured":"K. Lovas, E.S. Husebye, Replacement therapy in Addison\u2019s disease. Expert Opin. Pharmacother. 4, 2145\u20132149 (2003)","journal-title":"Expert Opin. Pharmacother."},{"key":"9835_CR64","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/S0140-6736(03)13492-7","volume":"361","author":"W Arlt","year":"2003","unstructured":"W. Arlt, B. Allolio, Adrenal insufficiency. Lancet 361, 1881\u20131893 (2003)","journal-title":"Lancet"},{"key":"9835_CR65","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1210\/jcem-72-1-39","volume":"72","author":"NV Esteban","year":"1991","unstructured":"N.V. Esteban, T. Loughlin, A.L. Yergay, J.K. Zawadki, J.D. Booth, J.C. Winterer et al., Daily cortisol production rate in man determined by stable isotope dilution\/mass spectrometry. J. Clin. Endocrinol. Metab. 72, 39\u201345 (1991)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR66","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1210\/jc.2006-0524","volume":"91","author":"H Filipsson","year":"2006","unstructured":"H. Filipsson, J.P. Monson, M. Koltowska-H\u00e4ggstr\u00f6m, A. Mattsson, G. Johansson, The impact of glucocorticoid replacement regimens on metabolic outcome and comorbidity in hypopituitary patients. J. Clin. Endocrinol. Metab. 91, 3954\u20133961 (2006)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR67","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1365-2265.2005.02421.x","volume":"64","author":"RM Reynolds","year":"2006","unstructured":"R.M. Reynolds, P.M. Stewart, J.R. Seckl, P.L. Padfield, Assessing the HPA axis in patients with pituitary disease: a UK survey. Clin. Endocrinol. (Oxf) 64, 82\u201385 (2006)","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"9835_CR68","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1365-2265.1981.tb00634.x","volume":"14","author":"CM Feek","year":"1981","unstructured":"C.M. Feek, J.G. Ratcliffe, J. Seth, C.E. Gray, A.D. Toft, W.J. Irvine, Patterns of plasma cortisol and ACTH concentrations in patients with Addison\u2019s disease treated with conventional corticosteroid replacement. Clin. Endocrinol. (Oxf.) 14, 451\u2013458 (1981)","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"9835_CR69","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/j.1365-2265.1978.tb01516.x","volume":"9","author":"RS Scott","year":"1978","unstructured":"R.S. Scott, R.A. Donald, E.A. Espiner, Plasma ACTH and cortisol profiles in Addisonian patients receiving conventional substitution therapy. Clin. Endocrinol. (Oxf.) 9, 571\u2013576 (1978)","journal-title":"Clin. Endocrinol. (Oxf.)"},{"issue":"2","key":"9835_CR70","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1177\/000456329903600203","volume":"36","author":"W Jeffcoate","year":"1999","unstructured":"W. Jeffcoate, Assessment of corticosteroid replacement therapy in adults with adrenal insufficiency. Ann. Clin. Biochem. 36(2), 151\u2013157 (1999)","journal-title":"Ann. Clin. Biochem."},{"key":"9835_CR71","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/BF03345252","volume":"26","author":"S Laureti","year":"2003","unstructured":"S. Laureti, A. Falorni, F. Santeusanio, Improvement of treatment of primary adrenal insufficiency by administration of cortisone acetate in three daily doses. J. Endocrinol. Invest. 26, 1071\u20131075 (2003)","journal-title":"J. Endocrinol. Invest."},{"key":"9835_CR72","doi-asserted-by":"crossref","unstructured":"W. Arlt, C. Rosenthal, S. Hahner, B. Allolio: Quality of glucocorticoid replacement in adrenal insufficiency: clinical assessment vs. timed serum cortisol measurements. Clin. Endocrinol. (Oxf.) 64, 384\u2013389 (2006)","DOI":"10.1111\/j.1365-2265.2006.02473.x"},{"key":"9835_CR73","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1365-2265.2004.02106.x","volume":"61","author":"PM Mah","year":"2004","unstructured":"P.M. Mah, R.C. Jenkins, A. Rostami-Hodjegan, J. Newell-Price, A. Doane et al., Weight-related dosing, timing and monitoring hydrocortisone replacement therapy in patients with adrenal insufficiency. Clin. Endocrinol. (Oxf.) 61, 367\u2013375 (2004)","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"9835_CR74","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/0026-0495(88)90164-3","volume":"37","author":"AW Meikle","year":"1988","unstructured":"A.W. Meikle, J.D. Stringham, M.G. Woodward, D.T. Bishop, Heritability of variation of plasma cortisol levels. Metabolism 37, 514\u2013517 (1988)","journal-title":"Metabolism"},{"key":"9835_CR75","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1530\/acta.0.0840600","volume":"84","author":"AL Barbato","year":"1977","unstructured":"A.L. Barbato, R.L. Landau, Serum cortisol appearance-disappearance in adrenal insufficiency after oral cortisone acetate. Acta Endocrinol. (Copenh.) 84, 600\u2013604 (1977)","journal-title":"Acta Endocrinol. (Copenh.)"},{"key":"9835_CR76","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1177\/014107688808100906","volume":"81","author":"RW Groves","year":"1988","unstructured":"R.W. Groves, G.C. Toms, B.J. Hougthon, J.P. Monson, Corticosteroid replacement therapy: twice or thrice daily? J.R.Soc.Med. 81, 514\u2013516 (1988)","journal-title":"J.R.Soc.Med."},{"key":"9835_CR77","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1007\/BF03347262","volume":"28","author":"L Barbetta","year":"2005","unstructured":"L. Barbetta, C. Dall\u2019Asta, T. Re, R. Lib\u00e8, E. Costa, B. Ambrosi, Comparison of different regimens of glucocorticoid replacement therapy in patients with hypoadrenalism. J. Endocrinol. Invest. 28, 632\u2013637 (2005)","journal-title":"J. Endocrinol. Invest."},{"key":"9835_CR78","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1046\/j.1365-2265.1997.1340955.x","volume":"46","author":"TA Howlett","year":"1997","unstructured":"T.A. Howlett, An assessment of optimal hydrocortisone replacement therapy. Clin. Endocrinol. (Oxf.) 46, 263\u2013268 (1997)","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"9835_CR79","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/j.1365-2265.2007.02812.x","volume":"66","author":"AH Thomson","year":"2007","unstructured":"A.H. Thomson, M.C. Devers, A.M. Wallace, D. Grant, K. Campbell et al., Variability in hydrocortisone plasma and saliva pharmacokinetics following intravenous and oral administration to patients with adrenal insufficiency. Clin. Endocrinol. (Oxf.) 66, 789\u2013796 (2007)","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"9835_CR80","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1677\/joe.0.1690065","volume":"169","author":"E Charmandari","year":"2001","unstructured":"E. Charmandari, A. Johnston, C.G. Brook, P.C. Hindmarsh, Bioavailability of oral hydrocortisone in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. J. Endocrinol. 169, 65\u201370 (2001)","journal-title":"J. Endocrinol."},{"key":"9835_CR81","doi-asserted-by":"crossref","first-page":"E183","DOI":"10.25011\/cim.v30i5.2894","volume":"30","author":"B Sauve","year":"2007","unstructured":"B. Sauve, G. Koren, G. Walsh, S. Tokmakejian, S.H. Van Uum, Measurement of cortisol in human hair as a biomarker of systemic exposure. Clin. Invest. Med. 30, E183\u2013E191 (2007)","journal-title":"Clin. Invest. Med."},{"key":"9835_CR82","doi-asserted-by":"crossref","first-page":"1621S","DOI":"10.1093\/jn\/131.5.1621S","volume":"131","author":"LF Hofman","year":"2001","unstructured":"L.F. Hofman, Human saliva as a diagnostic specimen. J. Nutr. 131, 1621S\u20131625S (2001)","journal-title":"J. Nutr."},{"key":"9835_CR83","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00421-009-0984-y","volume":"106","author":"A Moreira","year":"2009","unstructured":"A. Moreira, F. Arsati, de Oliveira Lima Arsati, Y.B., da Silva, D.A. de Araujo, V.C. Salivary cortisol in top-level professional soccer players. Eur. J. Appl. Physiol. 106, 25\u201330 (2009)","journal-title":"Eur. J. Appl. Physiol."},{"key":"9835_CR84","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0022-4731(83)80035-1","volume":"19","author":"D Riad-Fahmy","year":"1983","unstructured":"D. Riad-Fahmy, G.F. Read, R.F. Walker, Salivary steroid assays for assessing variation in endocrine activity. J. Steroid Biochem. 19, 265\u2013272 (1983)","journal-title":"J. Steroid Biochem."},{"key":"9835_CR85","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1373\/clinchem.2008.108910","volume":"54","author":"M Groschl","year":"2008","unstructured":"M. Groschl, Current status of salivary hormone analysis. Clin. Chem. 54, 1759\u20131769 (2008)","journal-title":"Clin. Chem."},{"key":"9835_CR86","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1210\/jc.2010-1215","volume":"95","author":"I Perogamvros","year":"2010","unstructured":"I. Perogamvros, B.G. Keevil, D.W. Ray, P.J. Trainer, Salivary cortisone is a potential biomarker for serum free cortisol. J. Clin. Endocrinol. Metab. 95, 4951\u20134958 (2010)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR87","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1258\/000456307780480954","volume":"44","author":"LD Dorn","year":"2007","unstructured":"L.D. Dorn, J.F. Lucke, T.L. Loucks, S.L. Berga, Salivary cortisol reflects serum cortisol: analysis of circadian profiles. Ann. Clin. Biochem. 44, 281\u2013284 (2007)","journal-title":"Ann. Clin. Biochem."},{"key":"9835_CR88","first-page":"139","volume":"27","author":"JG Lewis","year":"2006","unstructured":"J.G. Lewis, Steroid analysis in saliva: an overview. Clin. Biochem. Rev. 27, 139\u2013146 (2006)","journal-title":"Clin. Biochem. Rev."},{"key":"9835_CR89","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1258\/acb.2008.008208","volume":"46","author":"P Wood","year":"2009","unstructured":"P. Wood, Salivary steroid assays \u2013 research or routine? Ann. Clin. Biochem. 46, 183\u2013196 (2009)","journal-title":"Ann. Clin. Biochem."},{"key":"9835_CR90","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1210\/jc.2006-0997","volume":"91","author":"JW Findling","year":"2006","unstructured":"J.W. Findling, H. Raff, Cushing\u2019s Syndrome: important issues in diagnosis and management. J. Clin. Endocrinol. Metab. 91, 3746\u20133753 (2006)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR91","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1210\/jc.2009-1166","volume":"94","author":"H Raff","year":"2009","unstructured":"H. Raff, Utility of salivary cortisol measurements in Cushing\u2019s syndrome and adrenal insufficiency. J. Clin. Endocrinol. Metab. 94, 3647\u20133655 (2009)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR92","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s12020-012-9661-8","volume":"41","author":"H Raff","year":"2012","unstructured":"H. Raff, Salivary cortisol and the diagnosis of Cushing\u2019s syndrome: a coming age. Endocrine 41, 353\u2013354 (2012)","journal-title":"Endocrine"},{"key":"9835_CR93","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1210\/jcem-71-3-639","volume":"71","author":"EM Scott","year":"1990","unstructured":"E.M. Scott, H.H. McGarrigle, G.C. Lachelin, The increase in plasma and saliva cortisol levels in pregnancy is not due to the increase in corticosteroid-binding globulin levels. J. Clin. Endocrinol. Metab. 71, 639\u2013644 (1990)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR94","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1542\/peds.2006-2558","volume":"120","author":"AM Maguire","year":"2007","unstructured":"A.M. Maguire, G.R. Ambler, B. Moore, M. McLean, M.G. Falleti, C.T. Cowell, Prolonged hypocortisolemia in hydrocortisone replacement regimens in adrenocorticotrophic hormone deficiency. Pediatrics 120, e164\u2013e171 (2007)","journal-title":"Pediatrics"},{"key":"9835_CR95","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1365-2265.2004.02062.x","volume":"61","author":"V Wong","year":"2004","unstructured":"V. Wong, T. Yan, A. Donald, M. McLean, Saliva and bloodspot cortisol: novel sampling methods to assess hydrocortisone replacement therapy in hypoadrenal patients. Clin. Endocrinol. (Oxf.) 61, 131\u2013137 (2004)","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"9835_CR96","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/BF03344183","volume":"29","author":"K Lov\u00e5s","year":"2006","unstructured":"K. Lov\u00e5s, T.E. Thorsten, E.S. Husebye, Saliva cortisol measurement: simple and reliable assessment of the glucocorticoid replacement therapy in Addison\u2019s disease. J. Endocrinol. Invest. 29, 727\u2013731 (2006)","journal-title":"J. Endocrinol. Invest."},{"key":"9835_CR97","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1530\/EJE-07-0052","volume":"157","author":"K Lov\u00e5s","year":"2007","unstructured":"K. Lov\u00e5s, E.S. Husebye, Continuous subcutaneous hydrocortisone infusion in Addison\u2019s disease. Eur. J. Endocrinol. 157, 109\u2013112 (2007)","journal-title":"Eur. J. Endocrinol."},{"key":"9835_CR98","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.clinbiochem.2008.01.015","volume":"41","author":"P Restituto","year":"2008","unstructured":"P. Restituto, J.C. Galofre, M.J. Gil, C. Mugueta, S. Santos et al., Advantage of salivary cortisol measurements in the diagnosis of glucocorticoid related disorders. Clin. Biochem. 41, 688\u2013692 (2008)","journal-title":"Clin. Biochem."},{"key":"9835_CR99","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1210\/jc.2006-2155","volume":"92","author":"E Badrick","year":"2007","unstructured":"E. Badrick, C. Kirschbaum, M. Kumari, A. Steptoe, K. O\u2019Donnell, M. Marmot, The relationship between smokling status and cortisol secretion. J. Clin. Endocrinol. Metab. 92, 819\u2013824 (2007)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR100","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1080\/00365510701819127","volume":"68","author":"AM Hansen","year":"2008","unstructured":"A.M. Hansen, A.H. Garde, R. Persson, Sources of biological and methodological variation in salivary cortisol and their impact on measurement among healthy adults: a review. Scand. J. Clin. Lab. Invest. 68, 448\u2013458 (2008)","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"9835_CR101","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/j.1365-2265.2005.02347.x","volume":"63","author":"J Vialard-Miguel","year":"2005","unstructured":"J. Vialard-Miguel, N. Belaidi, L. Lembeye, J.B. Corcuff, Lemon juice alters cortisol assays in saliva. Clin. Endocrinol. (Oxf.) 63, 478\u2013479 (2005)","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"9835_CR102","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0039-128X(01)00111-8","volume":"66","author":"M Groschl","year":"2001","unstructured":"M. Groschl, R. Wagner, M. Rauh, H.G. Dorr, Stability of salivary steroids: the influences of storage, food and dental care. Steroids 66, 737\u2013741 (2001)","journal-title":"Steroids"},{"key":"9835_CR103","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1196\/annals.1410.065","volume":"1148","author":"MC Garcia","year":"2008","unstructured":"M.C. Garcia, A. de Souza, G.P. Bella, D.M. Grassi-Kassisse, A.P. Tacla, R.C. Sapadari-Bratfisch, Salivary cortisol levels in Brazilian citizens of distintc socioeconomic and cultural levels. Ann.N.Y.Acad.Sci. 1148, 504\u2013508 (2008)","journal-title":"Ann.N.Y.Acad.Sci."},{"key":"9835_CR104","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.psychres.2007.06.012","volume":"159","author":"GL Brown","year":"2008","unstructured":"G.L. Brown, E.L. McGarvey, E.A. Schirtcliff, A. Keller, D.A. Granger, K. Flavin, Salivary cortisol, dehydroepiandrosterone, and testosterone interrelationships in healthy young males: a pilot study with implications for studies of aggressive behavior. Psychistry Res. 159, 67\u201376 (2008)","journal-title":"Psychistry Res."},{"key":"9835_CR105","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1530\/EJE-09-0884","volume":"162","author":"S Hahner","year":"2010","unstructured":"S. Hahner, M. Loeefler, B. Bleicken, C. Drechsler, D. Milovanovic, M. Fassnacht, M. Ventz, M. Quinkler, B. Allolio, Epidemiology of adrenal crisis in chronic adrenal insufficiency: the need for new prevention strategies. Eur. J. Endocrinol. 162, 597\u2013602 (2010)","journal-title":"Eur. J. Endocrinol."},{"key":"9835_CR106","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1530\/EJE-09-0559","volume":"162","author":"K White","year":"2010","unstructured":"K. White, W. Arlt, Adrenal crisis in treated Addison\u2019s disease: a predictable but under-managed event. Eur. J. Endocrinol. 162, 115\u2013120 (2010)","journal-title":"Eur. J. Endocrinol."},{"key":"9835_CR107","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.amjmed.2009.12.017","volume":"123","author":"AJ Chakera","year":"2010","unstructured":"A.J. Chakera, B. Vaidya, Addison\u2019s disease in adults: diagnosis and management. Am. J. Medicine 123, 409\u2013413 (2010)","journal-title":"Am. J. Medicine"},{"key":"9835_CR108","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/BF03351071","volume":"27","author":"W Oelkers","year":"2004","unstructured":"W. Oelkers, Mineralocorticoid substitution in pregnant Addisonian women. J. Endocrinol. Invest. 27, 406 (2004)","journal-title":"J. Endocrinol. Invest."},{"key":"9835_CR109","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1530\/EJE-11-0518","volume":"165","author":"P Methlie","year":"2011","unstructured":"P. Methlie, E.E. Husebye, S. Hustad, E.A. Lien, K. L\u00f8v\u00e5s, Grapefruit juice and licorice increase cortisol availability in patients with Addison\u2019s disease. Eur. J. Endocrinol. 165, 761\u2013769 (2011)","journal-title":"Eur. J. Endocrinol."},{"key":"9835_CR110","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1258\/000456307780945624","volume":"44","author":"H Cooper","year":"2007","unstructured":"H. Cooper, B. Bhattacharya, V. Verma, A.J. McCulloch, W.S. Smellie, A.H. Heald, Liquorice and soy sauce, a life-saving concoction in a patient with Addison\u2019s disease. Ann. Clin. Biochem. 44, 397\u2013399 (2007)","journal-title":"Ann. Clin. Biochem."},{"key":"9835_CR111","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/BF03347034","volume":"26","author":"B Ambrosi","year":"2003","unstructured":"B. Ambrosi, L. Barbetta, L. Morricone, Diagnosis and management of Addison\u2019s disease during pregnancy. J. Endocrinol. Invest. 26, 698\u2013702 (2003)","journal-title":"J. Endocrinol. Invest."},{"key":"9835_CR112","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1056\/NEJM198612113152405","volume":"315","author":"E Barrett-Connor","year":"1986","unstructured":"E. Barrett-Connor, K.T. Khaw, S.S.C. Yen, A prospective study of dehydroepiandrosterone sulfate, mortality and cardiovascular disease. N. Engl. J. Med. 315, 1519\u20131524 (1986)","journal-title":"N. Engl. J. Med."},{"key":"9835_CR113","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/S0140-6736(94)92587-9","volume":"343","author":"P Ebeling","year":"1994","unstructured":"P. Ebeling, V.A. Kiovisto, Physiological importance of dehydroepiandrosterone. Lancet 343, 1479\u20131481 (1994)","journal-title":"Lancet"},{"key":"9835_CR114","first-page":"357","volume":"19","author":"P Sambrook","year":"1992","unstructured":"P. Sambrook, J. Birmingham, D. Champion, P. Kelly, S. Kempler, J. Freund, J. Eisman, Postmenopausal bone loss in rheumatoid arthritis: effect of estrogens and androgens. J. Rheumatol. 19, 357\u2013361 (1992)","journal-title":"J. Rheumatol."},{"key":"9835_CR115","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1007\/BF03347515","volume":"27","author":"R Lib\u00e8","year":"2004","unstructured":"R. Lib\u00e8, L. Barbetta, C. Dall\u2019Asta, F. Salvaggio, C. Gala, P. Beck-Peccoz, B. Ambrosi, Effects of dehydroepiandrosterone (DHEA) supplementation on hormonal, metabolic and behavioral status in patients with hypoadrenalism. J. Endocrinol. Invest. 27, 736\u2013741 (2004)","journal-title":"J. Endocrinol. Invest."},{"key":"9835_CR116","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1056\/NEJM199909303411401","volume":"341","author":"W Arlt","year":"1999","unstructured":"W. Arlt, F. Callies, J.C. van Vlijmen, I. Koehler, M. Reincke, M. Bidlingmaier, D. Huebler, M. Oettel, M. Ernst, H.M. Schulte, B. Allolio, Dehydroepiandrosterone replacement in women with adrenal insufficiency. N. Engl. J. Med. 341, 1013\u20131020 (1999)","journal-title":"N. Engl. J. Med."},{"key":"9835_CR117","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1210\/jc.85.12.4650","volume":"85","author":"PJ Hunt","year":"2000","unstructured":"P.J. Hunt, E.M. Gurnell, F.A. Huppert, C. Richards, A.T. Prevost, J.A. Wass, J. Herbert, V.K. Chatterjee, Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison\u2019s disease in a randomized, double blind trial. J. Clin. Endocrinol. Metab. 85, 4650\u20134656 (2000)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR118","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1210\/jc.2007-1134","volume":"93","author":"EM Gurnell","year":"2008","unstructured":"E.M. Gurnell, P.J. Hunt, S.E. Curran, C.L. Conway, E.M. Pullenayegum, F.A. Huppert, J.E. Compston, J. Herbert, V.K.K. Chatterjee, Long-term DHEA replacement in primary adrenal insufficiency: a randomized, controlled trial. J. Clin. Endocrinol. Metab. 93, 400\u2013409 (2008)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR119","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1210\/jc.2006-0076","volume":"91","author":"R Bergthorsdottir","year":"2006","unstructured":"R. Bergthorsdottir, M. Leonsson-Zachrisson, A. Od\u00e9n, G. Johannsson, Premature mortality in patients with Addison\u2019s disease: a population-based study. J. Clin. Endocrinol. Metab. 91, 4849\u20134853 (2006)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR120","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1365-2265.2008.03340.x","volume":"69","author":"S Bensing","year":"2008","unstructured":"S. Bensing, L. Brandt, F. Tabaroj, O. Sj\u00f6berg, B. Nilsson, A. Ekbom, P. Blomqvist, O. K\u00e4mpe, Increased death risk and altered cancer incidence pattern in patients with isolated or combined autoimmune primary adrenocortical insufficiency. Clin. Endocrinol. (Oxf.) 69, 697\u2013704 (2008)","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"9835_CR121","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1530\/EJE-08-0550","volume":"160","author":"MM Erichsen","year":"2009","unstructured":"M.M. Erichsen, K. L\u00f8v\u00e5s, K.J. Fougner, J. Svartberg, E.R. Hauge, J. Bollerslev, J.P. Berg, B. Mella, E.S. Husebye, Normal overall mortality rate in Addison\u2019s disease, but young patients are at risk of premature death. Eur. J. Endocrinol. 160, 233\u2013237 (2009)","journal-title":"Eur. J. Endocrinol."},{"key":"9835_CR122","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0140-6736(90)91812-O","volume":"336","author":"T Ros\u00e9n","year":"1990","unstructured":"T. Ros\u00e9n, B.A. Bengtsson, Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 336, 285\u2013288 (1990)","journal-title":"Lancet"},{"key":"9835_CR123","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0140-6736(00)04006-X","volume":"357","author":"JW Tomlinson","year":"2001","unstructured":"J.W. Tomlinson, N. Holden, R.K. Hills, K. Wheatley, R.N. Clayton, A.S. Bates, M.C. Sheppard, P.M. Stewart, Association between premature mortality and hypopituitarism. West Midlands Propsective Hypopituitary Study Group. Lancet 357, 425\u2013431 (2001)","journal-title":"Lancet"},{"key":"9835_CR124","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jpeds.2003.12.036","volume":"144","author":"JL Mills","year":"2004","unstructured":"J.L. Mills, L.B. Schonberger, D.K. Wysowski, P. Brown, S.J. Durako, C. Cox, F. Kong, J.E. Fradkin, Long-term mortality in the United States cohort of pituitary-derived growth hormone recipients. J. Pediatr. 144, 430\u2013436 (2004)","journal-title":"J. Pediatr."},{"key":"9835_CR125","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0021-9150(87)90117-1","volume":"63","author":"WH Ettinger","year":"1987","unstructured":"W.H. Ettinger, H.F. Klinefelter, P.O. Kwiterovitch, Effect of short-term, low-dose corticosteroids on plasma lipoprotein lipids. Atherosclerosis 63, 167\u2013172 (1987)","journal-title":"Atherosclerosis"},{"key":"9835_CR126","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/art.21329","volume":"53","author":"HK Choi","year":"2005","unstructured":"H.K. Choi, J.D. Seeger, Glucocorticoid use and serum lipid levels in US adults: the Third National Health and Nutrition Examination Survey. Arthritis Rheum. 53, 528\u2013535 (2005)","journal-title":"Arthritis Rheum."},{"key":"9835_CR127","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/BOR.0b013e3282f51031","volume":"20","author":"AK McDonough","year":"2008","unstructured":"A.K. McDonough, J.R. Curtis, K.G. Saag, The epidemiology of glucocorticoid-associated adverse events. Curr. Opin. Rheumatol. 20, 131\u2013137 (2008)","journal-title":"Curr. Opin. Rheumatol."},{"key":"9835_CR128","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/art.23352","volume":"59","author":"I Karp","year":"2008","unstructured":"I. Karp, M. Abrahamowicz, P.R. Fortin, L. Pilote, C. Neville, C. Pineau et al., Recent corticosteroid use and recent disease activity: independent determinants of coronary heart disease risk factors in systemic lupus erythematosus? Arthritis Rheum. 59, 169\u2013175 (2008)","journal-title":"Arthritis Rheum."},{"key":"9835_CR129","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1365-2362.2008.02067.x","volume":"39","author":"DH Raalte van","year":"2009","unstructured":"D.H. van Raalte, D.M. Ouwens, M. Diamant, Novel insights into glucocorticoid-mediated diabetogenic effects: towards expansion of therapeutic options? Eur. J. Clin. Invest. 39, 81\u201393 (2009)","journal-title":"Eur. J. Clin. Invest."},{"key":"9835_CR130","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nrrheum.2012.93","volume":"8","author":"K Walker-Bone","year":"2012","unstructured":"K. Walker-Bone, Recognizing and treating secondary osteoporosis. Nat. Rev. Rheumatol. 8, 480\u2013492 (2012)","journal-title":"Nat. Rev. Rheumatol."},{"key":"9835_CR131","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1097\/HJH.0b013e32834c465d","volume":"29","author":"GP Rossi","year":"2011","unstructured":"G.P. Rossi, T.M. Seccia, C. Maniero, A.C. Pessina, Drug-related hypertension and resistance to antihypertensive treatment: a call for action. J. Hypertens. 29, 2295\u20132309 (2011)","journal-title":"J. Hypertens."},{"key":"9835_CR132","doi-asserted-by":"crossref","unstructured":"J.L. Beaudry, M.C. Riddell, Effects of glucocorticoids and exercise on pancreatic \u03b2 cell function and diabetes development. Diabetes Metab. Res. Rev. doi: 10.1002\/dmrr.2310 (2012)","DOI":"10.1002\/dmrr.2310"},{"key":"9835_CR133","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0009-8981(89)90342-2","volume":"180","author":"MN Nanjee","year":"1989","unstructured":"M.N. Nanjee, N.E. Miller, Plasma lipoproteins and adrenocortical hormones in men\u2014positive association of low density lipoprotein cholesterol with plasma cortisol concentration. Clin. Chim. Acta 180, 113\u2013120 (1989)","journal-title":"Clin. Chim. Acta"},{"key":"9835_CR134","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1210\/jc.82.8.2653","volume":"82","author":"KA al-Shoumer","year":"1997","unstructured":"K.A. al-Shoumer, K.H. Cox, C.L. Hughes, W. Richmond, D.G. Johnston, Fasting and postprandial lipid abnormalities in hypopituitary women receiving conventional replacement therapy. J.Clin.Endocrinol.Metab. 82, 2653\u20132659 (1997)","journal-title":"J.Clin.Endocrinol.Metab."},{"key":"9835_CR135","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/0140-6736(92)92892-J","volume":"340","author":"V Markussis","year":"1992","unstructured":"V. Markussis, S.A. Beshyah, C. Fisher, P. Sharp, A.N. Nicolaides, D.G. Johnston, Detection of premature atherosclerosis by high-resolution ultrasonography in symptom-free hypopituitary adults. Lancet 340, 1188\u20131192 (1992)","journal-title":"Lancet"},{"key":"9835_CR136","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/BF03345773","volume":"32","author":"R Giordano","year":"2009","unstructured":"R. Giordano, S. Marzotti, M. Balbo, S. Romagnoli, E. Marinazzo, R. Berardelli, G. Migliaretti, A. Benso, A. Falorni, E. Ghigo, E. Arvat, Metabolic and cardiovascular profile in patients with Addison\u2019s disease under conventional glucocorticoid replacement. J. Endocrinol. Invest. 32, 917\u2013923 (2009)","journal-title":"J. Endocrinol. Invest."},{"key":"9835_CR137","doi-asserted-by":"crossref","unstructured":"R. Giordano, S. Marzotti, R. Berardelli, I. Karamouzis, A. Brozzetti, V. D\u2019Angelo, G. Mengozzi, G. Mandrile, D. Giachino, G. Migliaretti, V. Bini, A. Falorni, E. Ghigo, E. Arvat, BCLI polymorphism of the glucocorticoid receptor gene is associated with increased obesity, impaired glucose metabolism and dyslipidemia in patients with Addison\u2019s disease. Clin. Endocrinol. (Oxf.). doi: 10.1111\/j.1365-2265.2012.04439.x (2012)","DOI":"10.1111\/j.1365-2265.2012.04439.x"},{"key":"9835_CR138","unstructured":"J.P. Devogelaer, J. Crabb\u00e9, C. Nagant de Deuxchaisnes, Bone mineral density in Addison\u2019s disease: evidence for an effect of adrenal androgens on bone mass. Br. Med. J. (Clin. Res. Ed.) 294, 798\u2013800 (1987)"},{"key":"9835_CR139","doi-asserted-by":"crossref","first-page":"207","DOI":"10.7326\/0003-4819-120-3-199402010-00005","volume":"120","author":"PM Zelissen","year":"1994","unstructured":"P.M. Zelissen, R.J. Croughs, P.P. van Rijk, J.A. Raymakers, Effect of glucocorticoid replacement therapy on bone mineral density in patients with Addison disease. Ann. Intern. Med. 120, 207\u2013210 (1994)","journal-title":"Ann. Intern. Med."},{"key":"9835_CR140","first-page":"52","volume":"107","author":"CM Florkowski","year":"1994","unstructured":"C.M. Florkowski, S.J. Holmes, J.R. Elliot, R.A. Donald, E.A. Espiner, Bone mineral density is reduced in female but not male subjects with Addison\u2019s disease. N. Z. Med. J. 107, 52\u201353 (1994)","journal-title":"N. Z. Med. J."},{"key":"9835_CR141","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0169-6009(08)80158-4","volume":"26","author":"MA Valero","year":"1994","unstructured":"M.A. Valero, M. Leon, M.P. Ruiz Valdepe\u00f1as, L. Larrodera, M.B. Lopez, K. Papapietro, A. Jara, F. Hawkins, Bone density and turnover in Addison\u2019s disease: effect of glucocorticoid treatment. Bone Miner. 26, 9\u201317 (1994)","journal-title":"Bone Miner."},{"key":"9835_CR142","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1365-2265.1997.780907.x","volume":"46","author":"SR Peacey","year":"1997","unstructured":"S.R. Peacey, C.Y. Guo, A.M. Robinson, A. Price, M.A. Giles, R. Eastell, A.P. Weetman, Glucocorticoid replacement therapy: are patients over treated and does it matter? Clin. Endocrinol. (Oxf.) 46, 255\u2013261 (1997)","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"9835_CR143","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s001980050251","volume":"10","author":"GD Braatvedt","year":"1999","unstructured":"G.D. Braatvedt, M. Joyce, M. Evans, J. Clearwater, I.R. Reid, Bone mineral density in patients with treated Addison\u2019s disease. Osteoporos. Int. 10, 435\u2013440 (1999)","journal-title":"Osteoporos. Int."},{"key":"9835_CR144","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1046\/j.1365-2265.2003.01761.x","volume":"58","author":"E J\u00f3dar","year":"2003","unstructured":"E. J\u00f3dar, M.P. Valdepe\u00f1as, G. Martinez, A. Jara, F. Hawkins, Long-term follow-up of bone mineral density in Addison\u2019s disease. Clin. Endocrinol. (Oxf.) 58, 617\u2013620 (2003)","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"9835_CR145","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1507\/endocrj.51.355","volume":"51","author":"N Chikada","year":"2004","unstructured":"N. Chikada, T. Imaki, M. Hotta, K. Sato, K. Takano, An assessment of bone mineral density in patients with Addison\u2019s disease and isolated ACTH deficiency treated with glucocorticoid. Endocr. J. 51, 355\u2013360 (2004)","journal-title":"Endocr. J."},{"key":"9835_CR146","first-page":"289","volume":"31","author":"G Bassotti","year":"2006","unstructured":"G. Bassotti, D. Di Sarra, D. Pietrobono, R. Schiaffini, T. Battocletti, T. D\u2019Amico, P. Gargiulo, Polyglandular autoimmune endocrine insufficiency complicated by severe osteoporosis. Minerva Endocrinol. 31, 289\u2013296 (2006)","journal-title":"Minerva Endocrinol."},{"key":"9835_CR147","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12020-010-9359-8","volume":"38","author":"L Leelarathna","year":"2010","unstructured":"L. Leelarathna, L. Breen, J.K. Powrie, S.M. Thomas, R. Guzder, B. McGowan, P.V. Carroll, Co-morbidities, management and clinical outcome of auto-immune Addison\u2019s disease. Endocrine 38, 113\u2013117 (2010)","journal-title":"Endocrine"},{"key":"9835_CR148","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1530\/EJE-08-0880","volume":"160","author":"K L\u00f8v\u00e5s","year":"2009","unstructured":"K. L\u00f8v\u00e5s, C.G. Gjesdal, M. Christensen, A.B. Wolff, B. Alm\u00e5s, J. Svartberg, K.J. Fougner, U. Syversen, J. Bollerslev, J.A. Falch, P.J. Hunt, V.K. Chatterjee, E.S. Husebye, Glucocorticoid replacement therapy and pharmacogenetics in Addison\u2019s disease: effects on bone. Eur. J. Endocrinol. 160, 993\u20131002 (2009)","journal-title":"Eur. J. Endocrinol."},{"key":"9835_CR149","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1365-2796.2011.02352.x","volume":"270","author":"S Bj\u00f6rnsdottir","year":"2011","unstructured":"S. Bj\u00f6rnsdottir, M. S\u00e4\u00e4f, S. Bensing, O. K\u00e4mpe, K. Micha\u00eblsson, J.F. Ludvigsson, Risk of hip fracture in Addison\u2019s disease: a population-based cohort study. J. Intern. Med. 270, 187\u2013195 (2011)","journal-title":"J. Intern. Med."},{"key":"9835_CR150","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1210\/jc.2011-2036","volume":"97","author":"KR Koetz","year":"2012","unstructured":"K.R. Koetz, M. Ventz, S. Diederich, M. Quinkler, Bone mineral density is not significantly reduced in adult patients on low-dose glucocorticoid replacement therapy. J. Clin. Endocrinol. Metab. 97, 85\u201392 (2012)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR151","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1530\/EJE-10-0125","volume":"163","author":"G Mazziotti","year":"2010","unstructured":"G. Mazziotti, T. Porcelli, A. Bianchi, V. Cimino, I. Patelli, C. Mejia, A. Fusco, A. Giampietro, L. De Marinis, A. Giustina, Glucocorticoid replacement therapy and vertebral fractures in hypopituitary adult males with GH deficiency. Eur. J. Endocrinol. 163, 15\u201320 (2010)","journal-title":"Eur. J. Endocrinol."},{"key":"9835_CR152","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1046\/j.1365-2265.2002.01466.x","volume":"56","author":"K Lovas","year":"2002","unstructured":"K. Lovas, J.H. Loge, E.S. Husebye, Subjective health status in Norwegian patients with Addison\u2019s disease. Clin. Endocrinol. (Oxf.) 56, 581\u2013588 (2002)","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"9835_CR153","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1210\/jc.2007-0685","volume":"92","author":"S Hahner","year":"2007","unstructured":"S. Hahner, M. Loeffler, M. Fassnacht, D. Weismann, A.C. Koschker, M. Quinkler et al., Impaired subjective health status in 256 patients with adrenal insufficiency on standard therapy based on cross-sectional analysis. J. Clin. Endocrinol. Metab. 92, 3912\u20133922 (2007)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR154","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1530\/EJE-08-0578","volume":"159","author":"B Bleicken","year":"2008","unstructured":"B. Bleicken, S. Hahner, M. Loeffler, M. Ventz, B. Allolio, M. Quinkler, Impaired subjective health status in chronic adrenal insufficiency: impact of different glucocorticoid replacement regimens. Eur. J. Endocrinol. 159, 811\u2013817 (2008)","journal-title":"Eur. J. Endocrinol."},{"key":"9835_CR155","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1210\/jc.2009-1711","volume":"95","author":"K L\u00f8v\u00e5s","year":"2010","unstructured":"K. L\u00f8v\u00e5s, S. Curran, M. Oksnes, E.S. Husebye, F.A. Huppert, V.K. Chatterjee, Development of a disease-specific quality of life questionnaire in Addison\u2019s disease. J. Clin. Endocrinol. Metab. 95, 545\u2013551 (2010)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR156","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1210\/jc.2011-1901","volume":"97","author":"M \u00d8ksnes","year":"2012","unstructured":"M. \u00d8ksnes, S. Bensing, A.L. Hulting, O. K\u00e4mpe, A. Hackemann, G. Meyer, K. Badenhoop, C. Betterle, A. Parolo, R. Giordano, A. Falorni, L. Papierska, W. Jeske, A.A. Kasperlik-Zaluska, V.K. Chatterjee, E.S. Husebye, K. L\u00f8v\u00e5s, Quality of life in European patients with Addison\u2019s disease: validity of the disease-specific questionnaire AddiQoL. J. Clin. Endocrinol. Metab. 97, 568\u2013576 (2012)","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"Suppl 2","key":"9835_CR157","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1038\/sj.ijo.0801276","volume":"24","author":"MF Dallman","year":"2000","unstructured":"M.F. Dallman, S.F. Akana, S. Bhatnagar, M.E. Bell, A.M. Strack, Bottomed out: metabolic significance of the circadian trough in glucocorticoid concentrations. Int. J. Obes. Relat. Metab. Disord. 24(Suppl 2), S40\u2013S46 (2000)","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"9835_CR158","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1210\/jc.2008-2380","volume":"94","author":"M Debono","year":"2009","unstructured":"M. Debono, C. Ghobadi, A. Rostami-Hodjegan, H. Huatan, M.J. Campbell, J. Newell-Price, K. Darzy, D.P. Merke, W. Arlt, R.J. Ross, Modified-release hydrocortisone to provide circadian cortisol profiles. J. Clin. Endocrinol. Metab. 94, 1548\u20131554 (2009)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR159","unstructured":"S. Verma, C. Vanryzin, N. Sinaii, M.S. Kim, L.K. Nieman, S. Ravindran, K.A. Calis, W. Arlt, R.J. Ross, D.P. Merke, A pharmacokinetic and pharmacodynamic study of delayed- and extended-release hydrocortisone (Chronocort) vs. conventional hydrocortysone (Cortef) in the treatment of congenital adrenal hyperplasia. Clin. Endocrinol. (Oxf.) 72, 441\u2013447 (2010)"},{"key":"9835_CR160","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1046\/j.0300-0664.2001.01447.x","volume":"56","author":"EM McConnell","year":"2002","unstructured":"E.M. McConnell, P.M. Bell, C. Ennis, D.R. Hadden, D.R. McCance, B. Sheridan, A.B. Atkinson, Effects of low-dose oral hydrocortisone replacement versus short-term reproduction of physiological serum cortisol concentrations on insulin action in adult-onset hypopituitarism. Clin. Endocrinol. (Oxf.) 56, 195\u2013201 (2002)","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"9835_CR161","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1210\/jc.85.11.4201","volume":"85","author":"D Garcia-Borreguero","year":"2000","unstructured":"D. Garcia-Borreguero, T.A. Wehr, O. Larrosa, J.J. Granizo, D. Hardwick, G.P. Chrousos, T.C. Friedman, Glucocorticoid replacement is permissive for rapid eye movement sleep and sleep consolidation in patients with adrenal insufficiency. J. Clin. Endocrinol. Metab. 85, 4201\u20134206 (2000)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR162","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1530\/EJE-09-0170","volume":"161","author":"G Johannsson","year":"2009","unstructured":"G. Johannsson, R. Bergthorsdottir, A.G. Nilsson, H. Lennernas, T. Hedner, S. Skrtic, Improving glucocorticoid replacement therapy using a novel modified-release hydrocortisone tablet: a pharmacokinetic study. Eur. J. Endocrinol. 161, 119\u2013130 (2009)","journal-title":"Eur. J. Endocrinol."},{"key":"9835_CR163","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1210\/jc.2011-1926","volume":"97","author":"G Johansson","year":"2012","unstructured":"G. Johansson, A.G. Nilsson, R. Bergthorsdottir, P. Burman, P. Dahlqvist, B. Ekman, B.E. Engstrom, T. Olsson, O. Ragnarsson, M. Ryberg, J. Wahlberg, B.M.K. Biller, J.P. Monson, P.M. Stewart, H. Lennernas, S. Skrtic, Improved cortisol exposure-time profile and outcome in patients with adrenal insufficiency: a prospective randomized trial of a novel hydrocortisone dual-release formulation. J. Clin. Endocrinol. Metab. 97, 473\u2013481 (2012)","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"9835_CR164","doi-asserted-by":"crossref","first-page":"3694","DOI":"10.1002\/eji.200526128","volume":"35","author":"AJ Coles","year":"2005","unstructured":"A.J. Coles, S. Thompson, A.L. Cox, S. Curran, E.M. Gurnell, V.K. Chatterjee, Dehydroepiandrosterone replacement in patients with Addison\u2019s disease has a bimodal effect on regulatory (CD4\u00a0+\u00a0CD25hi and CD4\u00a0+\u00a0FoxP3\u00a0+) T cells. Eur. J. Immunol. 35, 3694\u20133703 (2005)","journal-title":"Eur. J. Immunol."},{"key":"9835_CR165","doi-asserted-by":"crossref","unstructured":"S.H. Pearce, A.L. Mitchell, S. Bennett, P. King, S. Chandran, S. Nag, S. Chen, B.R. Smith, J.D. Isaacs, B. Vaidya, Adrenal steroidogenesis after b lymphocyte depletion therapy in new-onset Addison\u2019s disease. J. Clin. Endocrinol. Metab. (2012). [Epub ahead of print]","DOI":"10.1210\/jc.2012-1680"},{"key":"9835_CR166","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1210\/jc.86.2.675","volume":"86","author":"A Bellis De","year":"2001","unstructured":"A. De Bellis, A. Falorni, S. Laureti et al., Time course of 21-hydroxylase antibodies and long-term remission of subclinical autoimmune adrenalitis after corticosteroid therapy: case report. J. Clin. Endocrinol. Metab. 86, 675\u2013678 (2001)","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-012-9835-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12020-012-9835-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-012-9835-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T22:50:42Z","timestamp":1643669442000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12020-012-9835-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,21]]},"references-count":166,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["9835"],"URL":"https:\/\/doi.org\/10.1007\/s12020-012-9835-4","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,21]]}}}