{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T17:12:38Z","timestamp":1794071558080,"version":"4.8.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endocrine"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1007\/s12020-012-9866-x","type":"journal-article","created":{"date-parts":[[2012,12,31]],"date-time":"2012-12-31T15:49:43Z","timestamp":1356968983000},"page":"359-368","source":"Crossref","is-referenced-by-count":69,"title":["Fisetin averts oxidative stress in pancreatic tissues of streptozotocin-induced diabetic rats"],"prefix":"10.1007","volume":"44","author":[{"given":"Gopalan Sriram","family":"Prasath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinnakrishnan Shanmuga","family":"Sundaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorimuthu Pillai","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,1,1]]},"reference":[{"key":"9866_CR1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.mad.2010.03.005","volume":"131","author":"R Pazdro","year":"2010","unstructured":"R. Pazdro, J.R. Burgess, The role of vitamin E and oxidative stress in diabetes complications. Mech. Ageing Dev. 131, 276\u2013286 (2010). doi: 10.1016\/j.mad.2010.03.005","journal-title":"Mech. Ageing Dev."},{"key":"9866_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodres.2007.10.001","volume":"41","author":"SS Ali","year":"2008","unstructured":"S.S. Ali, N. Kasoju, A. Luthra, A. Singh, H. Sharanabasava, A. Sahu, Indian medicinal herbs as sources of antioxidants. Food Res. Int. 41, 1\u201315 (2008). doi: 10.1016\/j.foodres.2007.10.001","journal-title":"Food Res. Int."},{"key":"9866_CR3","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","volume":"54","author":"M Brownlee","year":"2005","unstructured":"M. Brownlee, The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54, 1615\u20131625 (2005). doi: 10.2337\/diabetes.54.6.161","journal-title":"Diabetes"},{"key":"9866_CR4","doi-asserted-by":"crossref","first-page":"240","DOI":"10.2174\/1874192401004010240","volume":"4","author":"C Karasu","year":"2010","unstructured":"C. Karasu, Glycoxidative stress and cardiovascular complications in experimentally-induced diabetes: effects of antioxidant treatment. Open Cardiovasc Med J. 4, 240\u2013256 (2010). doi: 10.2174\/1874192401004010240","journal-title":"Open Cardiovasc Med J."},{"key":"9866_CR5","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.foodchem.2008.06.026","volume":"112","author":"R Scherer","year":"2009","unstructured":"R. Scherer, H.T. Godoy, Antioxidant activity index (AAI) by the 2, 2 diphenyl-1-picrylhydrazyl method. Food Chem. 112, 654\u2013658 (2009). doi: 10.1016\/j.foodchem.2008.06.026","journal-title":"Food Chem."},{"key":"9866_CR6","doi-asserted-by":"crossref","first-page":"6837","DOI":"10.1021\/jf2013875","volume":"59","author":"JW Finley","year":"2011","unstructured":"J.W. Finley, A.N. Kong, K.J. Hintze, E.H. Jeffery, L.L. Ji, X.G. Lei, Antioxidants in foods: state of the science important to the food industry. J. Agric. Food Chem. 59, 6837\u20136846 (2011). doi: 10.1021\/jf201387","journal-title":"J. Agric. Food Chem."},{"key":"9866_CR7","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1016\/j.foodres.2011.09.015","volume":"44","author":"PC Wootton-Beard","year":"2011","unstructured":"P.C. Wootton-Beard, L. Ryan, Improving public health?: the role of antioxidant-rich fruit and vegetable beverages. Food Res. Int. 44, 3135\u20133148 (2011). doi: 10.1016\/j.foodres.2011.09.015","journal-title":"Food Res. Int."},{"key":"9866_CR8","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1021\/jf00032a015","volume":"41","author":"MGL Hertog","year":"1993","unstructured":"M.G.L. Hertog, P.C.H. Hollman, B. van de Putte, Content of potentially anticarcinogenic flavonoids of tea infusions, wines and fruit juices. J. Agric. Food Chem. 41, 1242\u20131246 (1993). doi: 10.1021\/jf00032a015","journal-title":"J. Agric. Food Chem."},{"key":"9866_CR9","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/S0006-2952(03)00425-8","volume":"66","author":"S Ozgov\u00e1","year":"2003","unstructured":"S. Ozgov\u00e1, J. Herm\u00e1nek, I. Gut, Different antioxidant effects of polyphenols on lipid peroxidation and hydroxyl radicals in the NADPH-, Fe-ascorbate- and Fe-microsomal systems. Biochem Pharmacol. 66, 1127\u20131137 (2003). doi: 10.1016\/S0006-2952(03)00425-8","journal-title":"Biochem Pharmacol."},{"key":"9866_CR10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0014-5793(00)01517-9","volume":"473","author":"FA Acker van","year":"2000","unstructured":"F.A. van Acker, O. Schouten, G.R. Haenen, W.J. van der Vijgh, A. Bast, Flavonoids can replace alpha-tocopherol as an antioxidant. FEBS Lett. 473, 145\u2013148 (2000). doi: 10.1016\/S0014-5793(00)01517-9","journal-title":"FEBS Lett."},{"key":"9866_CR11","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1093\/jn\/130.9.2243","volume":"130","author":"Y Arai","year":"2000","unstructured":"Y. Arai, S. Watanabe, M. Kimira, K. Shimoi, R. Mochizuki, N. Kinae, Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J. Nutr. 130, 2243\u20132250 (2000)","journal-title":"J. Nutr."},{"key":"9866_CR12","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1093\/carcin\/bgq115","volume":"31","author":"Y Suh","year":"2010","unstructured":"Y. Suh, F. Afaq, N. Khan, J.J. Johnson, F.H. Khusro, H. Mukhtar, Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells. Carcinogenesis 31, 1424\u20131433 (2010). doi: 10.1093\/carcin\/bgq115","journal-title":"Carcinogenesis"},{"key":"9866_CR13","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0950-351X(98)80009-8","volume":"12","author":"T Fotsis","year":"1998","unstructured":"T. Fotsis, M.S. Pepper, R. Montesano, E. Aktas, S. Breit, L. Schweigerer, S. Rasku, K. W\u00e4h\u00e4l\u00e4, H. Adlercreutz, Phytoestrogens and inhibition of angiogenesis. Bailliere Clin Endocr. 12, 649\u2013666 (1998)","journal-title":"Bailliere Clin Endocr."},{"key":"9866_CR14","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/BF02974647","volume":"21","author":"H Cheong","year":"1998","unstructured":"H. Cheong, S.Y. Ryu, M.H. Oak, S.H. Cheon, G.S. Yoo, K.M. Kim, Studies of structure activity relationship of flavonoids for the anti-allergic actions. Arch. Pharm Res. 21, 478\u2013480 (1998)","journal-title":"Arch. Pharm Res."},{"key":"9866_CR15","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1021\/tx950076m","volume":"9","author":"RL Divi","year":"1996","unstructured":"R.L. Divi, D.R. Doerge, Inhibition of thyroid peroxidase by dietary flavonoids. Chem. Res. Toxicol. 9, 16\u201323 (1996). doi: 10.1021\/tx950076m","journal-title":"Chem. Res. Toxicol."},{"key":"9866_CR16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/cbf.1635","volume":"28","author":"RP Constantin","year":"2010","unstructured":"R.P. Constantin, J. Constantin, C.L. Pagadigorria, E.L. Ishii-Iwamoto, A. Bracht, K. Ono Mde, N.S. Yamamoto, The actions of fisetin on glucose metabolism in the rat liver. Cell Biochem. Funct. 28, 149\u2013158 (2010). doi: 10.1002\/cbf.1635","journal-title":"Cell Biochem. Funct."},{"key":"9866_CR17","first-page":"68","volume":"6","author":"G SriramPrasath","year":"2011","unstructured":"G. SriramPrasath, S. Subramanian, Fistein, a bioflavonoid ameliorates hyperglycemia in STZ induced experimental diabetes in rats. Int J Pharm Sci Rev Res 6, 68\u201374 (2011)","journal-title":"Int J Pharm Sci Rev Res"},{"key":"9866_CR18","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.ejphar.2011.07.021","volume":"668","author":"GS Prasath","year":"2011","unstructured":"G.S. Prasath, S.P. Subramanian, Modulatory effects of fisetin, a bioflavonoid, on hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in hepatic and renal tissues in streptozotocin-induced diabetic rats. Eur. J. Pharmacol. 668, 492\u2013496 (2011). doi: 10.1016\/j.ejphar.2011.07.021","journal-title":"Eur. J. Pharmacol."},{"key":"9866_CR19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0023-6438(95)80008-5","volume":"28","author":"W Brand-Williams","year":"1995","unstructured":"W. Brand-Williams, M.E. Cuvelier, C. Berset, Use of a free-radical method to evaluate antioxidant activity. Food Sci Technol-Leb. 28, 25\u201330 (1995). doi: 10.1016\/S0023-6438(95)80008-5","journal-title":"Food Sci Technol-Leb."},{"key":"9866_CR20","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","volume":"26","author":"R Re","year":"1999","unstructured":"R. Re, N. Pellegrini, A. Proteggente, A. Pannala, M. Yang, C. Rice-Evans, Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 26, 1231\u20131237 (1999)","journal-title":"Free Radic Biol Med."},{"key":"9866_CR21","first-page":"91","volume":"29","author":"N Rakieten","year":"1963","unstructured":"N. Rakieten, M.L. Rakieten, M.V. Nadkarni, Studies on the diabetogenic action of streptozotocin (NSC-37917). Cancer Chemother Rep. 29, 91\u201398 (1963)","journal-title":"Cancer Chemother Rep."},{"key":"9866_CR22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3109\/10408447509079859","volume":"3","author":"LJ Fischer","year":"1975","unstructured":"L.J. Fischer, D.E. Rickert, Pancreatic islet-cell toxicity. Crit. Rev. Toxicol. 3, 231\u2013263 (1975)","journal-title":"Crit. Rev. Toxicol."},{"key":"9866_CR23","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0009-8981(81)90312-0","volume":"109","author":"SS Nayak","year":"1981","unstructured":"S.S. Nayak, T.N. Pattabiraman, A new colorimetric method for the estimation of glycosylated hemoglobin. Clin. Chim. Acta 109, 267\u2013274 (1981)","journal-title":"Clin. Chim. Acta"},{"key":"9866_CR24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"O.H. Lowry, N.J. Rosebrough, A.L. Farr, R.J. Randall, Protein measurement with the folin phenol reagent. J. Biol. Chem. 193, 265\u2013275 (1951)","journal-title":"J. Biol. Chem."},{"key":"9866_CR25","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","volume":"247","author":"HP Misra","year":"1972","unstructured":"H.P. Misra, T. Fridrovich, The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J. Biol. Chem. 247, 3170\u20133175 (1972)","journal-title":"J. Biol. Chem."},{"key":"9866_CR26","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1172\/JCI104075","volume":"39","author":"S Takahara","year":"1960","unstructured":"S. Takahara, H.B. Hamilton, J.V. Neel, T.Y. Kobara, Y. Ogura, E.T. Nishimura, Hypocatalasemia: a new genetic carrier state. J Clin Invest. 39, 610\u2013619 (1960)","journal-title":"J Clin Invest."},{"key":"9866_CR27","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","volume":"179","author":"JT Rotruck","year":"1973","unstructured":"J.T. Rotruck, A.L. Pope, H.E. Ganther, A.B. Swanson, D.G. Hafeman, W.G. Hoekstra, Selenium: biochemical role as a component of glutathione peroxidase. Science 179, 588\u2013590 (1973)","journal-title":"Science"},{"key":"9866_CR28","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","volume":"249","author":"WH Habig","year":"1974","unstructured":"W.H. Habig, M.J. Pabst, W.B. Jakoby, Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249, 7130\u20137139 (1974)","journal-title":"J. Biol. Chem."},{"key":"9866_CR29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0076-6879(79)62181-X","volume":"62","author":"ST Omaye","year":"1979","unstructured":"S.T. Omaye, J.D. Turnbull, H.E. Sauberlich, Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids. Methods Enzymol. 62, 3\u201311 (1979)","journal-title":"Methods Enzymol."},{"key":"9866_CR30","unstructured":"Desai J.D.: Methods in enzymology. In: Parker (eds), pp. 138. Academic Press, New York, (1984)"},{"key":"9866_CR31","first-page":"161","volume":"58","author":"HA Ravin","year":"1961","unstructured":"H.A. Ravin, An improved colorimetric enzymatic assay of ceruloplasmin. J. Lab. Clin. Med. 58, 161\u2013168 (1961)","journal-title":"J. Lab. Clin. Med."},{"key":"9866_CR32","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","volume":"25","author":"J Sedlak","year":"1968","unstructured":"J. Sedlak, R.H. Lindsay, Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman\u2019s reagent. Anal. Biochem. 25, 192\u2013205 (1968)","journal-title":"Anal. Biochem."},{"key":"9866_CR33","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"H. Ohkawa, N. Ohishi, K. Yagi, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95, 351\u2013358 (1979)","journal-title":"Anal. Biochem."},{"key":"9866_CR34","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/0003-2697(92)90122-N","volume":"202","author":"ZY Jiang","year":"1992","unstructured":"Z.Y. Jiang, J.V. Hunt, S.P. Wolff, Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein. Anal. Biochem. 202, 384\u2013389 (1992)","journal-title":"Anal. Biochem."},{"key":"9866_CR35","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","volume":"126","author":"LC Green","year":"1982","unstructured":"L.C. Green, D.A. Wagner, J. Glogowski, P.L. Skipper, J.S. Wishnok, S.R. Tannenbaum, Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal. Biochem. 126, 131\u2013138 (1982)","journal-title":"Anal. Biochem."},{"key":"9866_CR36","first-page":"61","volume-title":"Theory and practice of histological techniques, microtomy and paraffin sections","author":"K Gordon","year":"1990","unstructured":"K. Gordon, P Bradbury, in Theory and practice of histological techniques, microtomy and paraffin sections, ed. by J.D. Bancroft, A. Stevens (Churchill Livingston, New York, 1990), pp. 61\u201380"},{"key":"9866_CR37","doi-asserted-by":"crossref","first-page":"537","DOI":"10.33549\/physiolres.930111","volume":"50","author":"T Szkudelski","year":"2001","unstructured":"T. Szkudelski, The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol. Res. 50, 537\u2013546 (2001)","journal-title":"Physiol. Res."},{"key":"9866_CR38","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/07435800500371805","volume":"31","author":"G Alper","year":"2005","unstructured":"G. Alper, S. Irer, E. Duman, O. Caglayan, C. Yilmaz, Effect of I-deprenyl and gliclazide on oxidant stress\/antioxidant status and DNA damage in a diabetic rat model. Endocr. Res. 31, 199\u2013212 (2005)","journal-title":"Endocr. Res."},{"key":"9866_CR39","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1016\/j.bmcl.2008.05.110","volume":"18","author":"HS Kang","year":"2008","unstructured":"H.S. Kang, K.R. Kim, E.M. Jun, S.H. Park, T.S. Lee, J.W. Suh, J.P. Kim, Cyathuscavins A, B, and C, new free radical scavengers with DNA protection activity from the Basidiomycete Cyathus stercoreus. Bioorg. Med. Chem. Lett. 18, 4047\u20134050 (2008). doi: 10.1016\/j.bmcl.2008.05.110","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"9866_CR40","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1582-4934.2009.00897.x","volume":"14","author":"JM L\u00fc","year":"2010","unstructured":"J.M. L\u00fc, P.H. Lin, Q. Yao, C. Chen, Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems. J. Cell Mol. Med. 14, 840\u2013860 (2010). doi: 10.1111\/j.1582-4934.2009.00897.x","journal-title":"J. Cell Mol. Med."},{"key":"9866_CR41","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1248\/cpb.53.714","volume":"53","author":"M Nishizawa","year":"2005","unstructured":"M. Nishizawa, M. Kohno, M. Nishimura, A. Kitagawa, Y. Niwano, Non-reductive scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) by peroxyradical: a useful method for quantitative analysis of peroxyradical. Chem Pharm Bull Tokyo 53, 714\u2013716 (2005)","journal-title":"Chem Pharm Bull Tokyo"},{"key":"9866_CR42","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0891-5849(98)00190-7","volume":"26","author":"EJ Lien","year":"1999","unstructured":"E.J. Lien, S. Ren, H.H. Bui, R. Wang, Quantitative structure-activity relationship analysis of phenolic antioxidants. Free Radic Biol Med. 26, 285\u2013294 (1999)","journal-title":"Free Radic Biol Med."},{"key":"9866_CR43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1383-5718(03)00114-1","volume":"540","author":"R Edenharder","year":"2003","unstructured":"R. Edenharder, D. Gr\u00fcnhage, Free radical scavenging abilities of flavonoids as mechanism of protection against mutagenicity induced by tert-butyl hydroperoxide or cumene hydroperoxide in Salmonella typhimurium TA102. Mutat. Res. 540, 1\u201318 (2003). doi: 10.1016\/S1383-5718(03)00114-1","journal-title":"Mutat. Res."},{"key":"9866_CR44","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1472-8206.1998.tb00951.x","volume":"12","author":"H Groot de","year":"1998","unstructured":"H. de Groot, U. Rauen, Tissue injury by reactive oxygen species and the protective effects of flavonoids. Fundam. Clin. Pharmacol. 12, 249\u2013255 (1998). doi: 10.1111\/j.1472-8206.1998.tb00951.x","journal-title":"Fundam. Clin. Pharmacol."},{"key":"9866_CR45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11010-011-0927-x","volume":"358","author":"R Babujanarthanam","year":"2011","unstructured":"R. Babujanarthanam, P. Kavitha, U.S. MahadevaRao, M.R. Pandian, Quercitrin a bioflavonoid improves the antioxidant status in streptozotocin: induced diabetic rat tissues. Mol Cell Biochem 358, 121\u2013129 (2011). doi: 10.1007\/s11010-011-0927-x","journal-title":"Mol Cell Biochem"},{"key":"9866_CR46","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1089\/ars.2012.4600","volume":"17","author":"S Malireddy","year":"2012","unstructured":"S. Malireddy, S.R. Kotha, J.D. Secor, T.O. Gurney, J.L. Abbott, G. Maulik, K.R. Maddipati, N.L. Parinandi, Phytochemical antioxidants modulate mammalian cellular epigenome: implications in health and disease. Antioxid. Redox Signal. 17, 327\u2013339 (2012)","journal-title":"Antioxid. Redox Signal."},{"key":"9866_CR47","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0891-5849(96)02051-5","volume":"20","author":"S Lenzen","year":"1996","unstructured":"S. Lenzen, J. Drinkgern, M. Tiedge, Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med. 20, 463\u2013466 (1996)","journal-title":"Free Radic Biol Med."},{"key":"9866_CR48","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1210\/endo-129-6-3167","volume":"129","author":"N Welsh","year":"1991","unstructured":"N. Welsh, D.L. Eizirik, K. Bendtzen, S. Sandler, Interleukin-1-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase. Endocrinology 129, 3167\u20133173 (1991)","journal-title":"Endocrinology"},{"key":"9866_CR49","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0896-8411(03)00039-8","volume":"20","author":"G Wachlin","year":"2003","unstructured":"G. Wachlin, P. Augstein, D. Schroder, B. Kuttler, I. Kloting, P. Heinke, S. Schmidt, IL-1 beta, IFN-gamma and TNF-alpha increase vulnerability of pancreatic beta cells to autoimmune destruction. J. Autoimmun. 20, 303\u2013312 (2003). doi: 10.1016\/S0896-8411(03)00039-8","journal-title":"J. Autoimmun."},{"key":"9866_CR50","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1126\/science.3086977","volume":"232","author":"K Bendtzen","year":"1986","unstructured":"K. Bendtzen, T. Mandrup-Poulsen, J. Nerup, J.H. Nielsen, C.A. Dinarello, M. Svenson, Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans. Science 232, 1545\u20131547 (1986). doi: 10.1126\/science.3086977","journal-title":"Science"},{"key":"9866_CR51","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/abbi.1998.1004","volume":"362","author":"C Park","year":"1999","unstructured":"C. Park, J.R. Kim, J.K. Shim, B.S. Kang, Y.G. Park, K.S. Nam, Y.C. Lee, C.H. Kim, Inhibitory effects of streptozotocin, tumor necrosis factor-\u03b1, and interleukin-1 on glucokinase activity in pancreatic islets and gene expression of GLUT2 and glucokinase. Arch. Biochem. Biophys. 362, 217\u2013224 (1999). doi: 10.1006\/abbi.1998.1004","journal-title":"Arch. Biochem. Biophys."},{"key":"9866_CR52","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1210\/en.138.6.2610","volume":"138","author":"CA Delaney","year":"1997","unstructured":"C.A. Delaney, D. Pavlovic, A. Hoorens, D.G. Pipeleers, D.L. Eizirik, Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells. Endocrinology 138, 2610\u20132614 (1997). doi: 10.1210\/en.138.6.2610","journal-title":"Endocrinology"}],"container-title":["Endocrine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-012-9866-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12020-012-9866-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12020-012-9866-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T15:28:32Z","timestamp":1745940512000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12020-012-9866-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,1]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["9866"],"URL":"https:\/\/doi.org\/10.1007\/s12020-012-9866-x","relation":{},"ISSN":["1355-008X","1559-0100"],"issn-type":[{"value":"1355-008X","type":"print"},{"value":"1559-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,1]]}}}